- 作 者: ( "mingxiong guo" OR "ming-xiong guo" )
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HBV X Protein Induces Degradation of UBXN7, a Novel Negative Regulator of NF-κB Signaling, to Promote HBV ReplicationCellular and Molecular Gastroenterology and Hepatology (IF 8.797) Pub Date : 2022-09-09 ,DOI:10.1016/j.jcmgh.2022.09.003Min Wang, Junsong Huang, Shuangshuang Ma, Yang Liu, Yujia Ke, Xianhuang Zeng, Kangwei Wu, Jingwen Wang, Xuezhang Tian, Dandan Zheng, Tanzeel Yousaf, Wajeeha Naz, Junwei Sun, Lang Chen, Deyin Guo, Mingxiong Guo, Guihong Sun
Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma. However, the function and mechanism of the effect of HBV on host protein ubiquitination remain largely unknown. We aimed at characterizing whether and how HBV promotes self-replication by affecting host protein ubiquitination. In this study, we identified UBXN7, a novel inhibitor for nuclear factor kappa B (NF-κB)
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Upregulation of miR-520c-3p via hepatitis B virus drives hepatocellular migration and invasion by the PTEN/AKT/NF-κB axisMolecular Therapy - Nucleic Acids (IF 10.183) Pub Date : 2022-05-20 ,DOI:10.1016/j.omtn.2022.05.031Yang Liu, Jingwen Wang, Jianwen Chen, Shaoshuai Wu, Xianhuang Zeng, Qiushuang Xiong, Yandan Guo, Junwei Sun, Feifei Song, Jiaqi Xu, Sen Yuan, Chuang Li, Yuan He, Ming Wang, Lang Chen, Yun-Bo Shi, Mingxiong Guo, Deyin Guo, Guihong Sun
Hepatitis B virus (HBV) is a major risk factor for the development and progression of hepatocellular carcinoma (HCC). It has been reported that viral infection can interfere with the expression of cellular microRNA (miRNA) to affect oncogenesis. In this study, we showed that miR-520c-3p was upregulated in liver tumor specimens, and we revealed that HBV infection enhanced the expression of miR-520c-3p
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Multiomics Analysis of Endocytosis upon HBV Infection and Identification of SCAMP1 as a Novel Host Restriction Factor against HBV ReplicationInternational Journal of Molecular Sciences (IF 4.556) Pub Date : 2022-02-18 ,DOI:10.3390/ijms23042211Tanzeel Yousaf, Yuting Sun, Wajeeha Naz, Yang Liu, Jiaqi Xu, Sen Yuan, Kangwei Wu, Min Wang, Jun Wang, Mingxiong Guo, Guihong Sun
Hepatitis B virus (HBV) infection remains a major global health problem and the primary cause of cirrhosis and hepatocellular carcinoma (HCC). HBV intrusion into host cells is prompted by virus–receptor interactions in clathrin-mediated endocytosis. Here, we report a comprehensive view of the cellular endocytosis-associated transcriptome, proteome and ubiquitylome upon HBV infection. In this study
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Circulating tumor cells in patients undergoing androgen deprivation therapy with versus without cryosurgery for metastatic prostate cancer: a retrospective analysisWorld Journal of Surgical Oncology (IF 3.253) Pub Date : 2021-12-13 ,DOI:10.1186/s12957-021-02455-4Sheng, Mingxiong, Guo, Shanming, Liu, Chunxiao
The study aimed to assess the value of circulating tumor cells (CTCs) as a prognostic and treatment response marker in patients undergoing androgen deprivation therapy (ADT) plus cryosurgery vs. ADT alone for metastatic prostate cancer (mPCA). This retrospective analysis included 43 patients with mPCA: 23 receiving ADT alone (control) and 20 receiving additional cryosurgery (cryosurgery group). CTCs
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hnRNPA2B1-Mediated Extracellular Vesicles Sorting of miR-122-5p Potentially Promotes Lung Cancer ProgressionInternational Journal of Molecular Sciences (IF 4.556) Pub Date : 2021-11-28 ,DOI:10.3390/ijms222312866Chuang Li, Fang Qin, Wei Wang, Yifan Ni, Mingyu Gao, Mingxiong Guo, Guihong Sun
Extracellular vesicles (EVs) released by tumor cells play important roles on the remodeling of the tumor–stromal environment and on promoting tumor metastasis. Our earlier studies revealed that miR-122-5p, a type of small non-coding RNA, was dysregulated in non-small cell lung cancer (NSCLC) cell-derived EVs. In this study, we found that miR-122-5p was selectively sorted and secreted into lung cancer
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Genome editing of CCR5 by AsCpf1 renders CD4+T cells resistance to HIV-1 infection.Cell and Bioscience (IF 9.584) Pub Date : 2020-07-08 ,DOI:10.1186/s13578-020-00444-wZhepeng Liu,Jin Liang,Shuliang Chen,Kewu Wang,Xianhao Liu,Beibei Liu,Yang Xia,Mingxiong Guo,Xiaoshi Zhang,Guihong Sun,Geng Tian
The chemokine receptor CCR5 is one of the co-receptor of HIV-1 infection. People with homozygous CCR5Δ32 deletion resist HIV-1 infection, which makes the CCR5 an important target for HIV-1 gene therapy. Although the CRISPR/Cas9 has ever been used for HIV-1 study, the newly developed CRISPR/AsCpf1 has never been utilized in HIV-1 co-receptor disruption. The CRISPR/Cpf1 system shows many advantages over
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KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.Cells (IF 7.666) Pub Date : 2019-12-10 ,DOI:10.3390/cells8121604Yi Liu,Wei Yin,Jingwen Wang,Yucong Lei,Guihong Sun,Wenxin Li,Zan Huang,Mingxiong Guo
Despite progress in understanding how virus-induced, NF-κB-dependent pro-inflammatory cytokines are regulated, there are still factors and mechanisms that remain to be explored. We aimed to uncover the relationship between KRAB-zinc finger protein ZNF268a and NF-κB-mediated cytokine production in response to viral infection. To this end, we established a ZNF268a-knockout cell line using a pair of sgRNAs
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Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.Cancer Science (IF 6.518) Pub Date : 2019-04-11 ,DOI:10.1111/cas.14004Feifei Song,Mingcong Wei,Jingwen Wang,Yang Liu,Mingxiong Guo,Xiaolu Li,Jun Luo,Junying Zhou,Min Wang,Deyin Guo,Lang Chen,Guihong Sun
Hepatocellular carcinoma (HCC) is a common cancer with poor prognosis. Hepatitis B virus (HBV) is one of the leading causes of HCC, but the precise mechanisms by which this infection promotes cancer development are not fully understood. Recently, miR-340-5p, a microRNA (miRNA) that has been identified as a cancer suppressor gene, was found to inhibit the migration and invasion of liver cancer cells
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Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP via NF-κB SignalingHepatology (IF 17.298) Pub Date : 2019-02-27 ,DOI:10.1002/hep.30248Jingwen Wang, Jianwen Chen, Yang Liu, Xianhuang Zeng, Mingcong Wei, Shaoshuai Wu, Qiushuang Xiong, Feifei Song, Xu Yuan, Yu Xiao, Yun Cao, Changyong Li, Lang Chen, Mingxiong Guo, Yun-Bo Shi, Guihong Sun, Deyin Guo
Hepatitis B virus (HBV) is a major risk factor for the development and progression of hepatocellular carcinoma. It has been reported that viral infection can interfere with cellular microRNA (miRNA) expression and participate in the pathogenesis of oncogenicity. Here, we report that decreasing levels of the expression of the miRNA miR‐192‐3p is associated with rising levels of HBV DNA in the serum
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miR-429 and miR-424-5p inhibit cell proliferation and Ca2+ influx by downregulating CaSR in pulmonary artery smooth muscle cells.American Journal of Physiology-Cell Physiology (IF 5.282) Pub Date : 2018-11-22 ,DOI:10.1152/ajpcell.00219.2018Chuang Li,Fang Qin,Mengmeng Xue,Yucong Lei,Fen Hu,Hui Xu,Guihong Sun,Tao Wang,Mingxiong GuoCytosolic free Ca2+ concentration is a key factor in pulmonary vasoconstriction and vascular remodeling of pulmonary artery smooth muscle cells (PASMCs). These processes contribute to pulmonary arterial hypertension and are influenced by expression of calcium-sensing receptor (CaSR). Although regulation of CaSR expression is precisely controlled, the contribution of microRNAs (miR) is incompletely ...
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[Mechanism of EGFR Over-expression and Mutations Leading to Biological Characteristics Changes of Human Lung Adenocarcinoma Cells through CXCR4/CXCL12 Signaling Pathway].Zhongguo fei ai za zhi = Chinese journal of lung cancer Pub Date : 2018-07-20 ,DOI:10.3779/j.issn.1009-3419.2018.07.01Jia Feng,Xueyan Wei,Chuang Li,Mingxiong Guo,Min Peng,Qibin Song,Guang HanBACKGROUND The epidermal growth factor receptor (EFGR) mutation was closely related to the invasion and metastasis of lung adenocarcinoma and the biological axis of CXCR4/CXCL12 (chemokine receptor 4/chemokine ligand 12) played an important role in the organ-specific metastasis of the tumor. It was a question surrounding whether there is interaction between them in the process of lung adenocarcinoma ...
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Characterization and selective incorporation of small non-coding RNAs in non-small cell lung cancer extracellular vesicles.Cell and Bioscience (IF 9.584) Pub Date : 2018-01-10 ,DOI:10.1186/s13578-018-0202-xChuang Li,Fang Qin,Fen Hu,Hui Xu,Guihong Sun,Guang Han,Tao Wang,Mingxiong Guo
BACKGROUND Extracellular vesicles (EVs) play important roles in intercellular communication through the delivery of their cargoes, which include proteins, lipids, and RNAs. Increasingly, multiple studies have reported the association between EV small non-coding RNAs and cancer, due to their regulatory functions in gene expression. Hence, analysis of the features of small non-coding RNA expression and
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MicroRNAs, DNA Damage Response, and Cancer Treatment.International Journal of Molecular Sciences (IF 6.208) Pub Date : 2016-12-16 ,DOI:10.3390/ijms17122087Mingyang He,Weiwei Zhou,Chuang Li,Mingxiong Guo
As a result of various stresses, lesions caused by DNA-damaging agents occur constantly in each cell of the human body. Generally, DNA damage is recognized and repaired by the DNA damage response (DDR) machinery, and the cells survive. When repair fails, the genomic integrity of the cell is disrupted-a hallmark of cancer. In addition, the DDR plays a dual role in cancer development and therapy. Cancer
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MicroRNAs, DNA Damage Response, and Cancer TreatmentInternational Journal of Molecular Sciences (IF 4.556) Pub Date : 2016-12-12 ,DOI:10.3390/ijms17122087Mingyang He, Weiwei Zhou, Chuang Li, Mingxiong Guo
As a result of various stresses, lesions caused by DNA-damaging agents occur constantly in each cell of the human body. Generally, DNA damage is recognized and repaired by the DNA damage response (DDR) machinery, and the cells survive. When repair fails, the genomic integrity of the cell is disrupted—a hallmark of cancer. In addition, the DDR plays a dual role in cancer development and therapy. Cancer
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miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells.Aging-US (IF 5.955) Pub Date : 2016-07-13 ,DOI:10.18632/aging.100998Mingyang He,Yi Lin,Yunlan Tang,Yi Liu,Weiwei Zhou,Chuang Li,Guihong Sun,Mingxiong Guo
The reduction of DNA damage repair capacity in terminally differentiated cells may be involved in sensitivity to cancer chemotherapy drugs; however, the underlying molecular mechanism is still not fully understood. Herein, we evaluated the role of miR-638 in the regulation of DNA damage repair in terminally differentiated cells. Our results show that miR-638 expression was up-regulated during cellular
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miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cellsAging Pub Date : 2016-07-12 ,DOI:10.18632/aging.100998Mingyang He, Yi Lin, Yunlan Tang, Yi Liu, Weiwei Zhou, Chuang Li, Guihong Sun, Mingxiong Guo
The reduction of DNA damage repair capacity in terminally differentiated cells may be involved in sensitivity to cancer chemotherapy drugs; however, the underlying molecular mechanism is still not fully understood. Herein, we evaluated the role of miR-638 in the regulation of DNA damage repair in terminally differentiated cells. Our results show that miR-638 expression was up-regulated during cellular
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The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.BMC Genomics (IF 4.547) Pub Date : 2016-05-06 ,DOI:10.1186/s12864-016-2664-8Jonathan Zhao,Xingyao Li,Mingxiong Guo,Jindan Yu,Chunhong Yan
BACKGROUND Dysregulation of the common stress responsive transcription factor ATF3 has been causally linked to many important human diseases such as cancer, atherosclerosis, infections, and hypospadias. Although it is believed that the ATF3 transcription activity is central to its cellular functions, how ATF3 regulates gene expression remains largely unknown. Here, we employed ATF3 wild-type and knockout
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FePt nanoparticles: a novel nanoprobe for enhanced HeLa cells sensitivity to chemoradiotherapyRSC Advances (IF 4.036) Pub Date : 2016-04-04 ,DOI:10.1039/c6ra03990aZhirong Bao,Mingyang He,Hong Quan,Dazhen Jiang,Yanhong Zheng,Wenjing Qin,Yunfeng Zhou,Feng Ren,Mingxiong Guo,Changzhong JiangChemoradiotherapy is a well-established treatment paradigm in oncology to consistently improve local tumor control compared to sole administration of chemotherapy or radiotherapy. Despite its importance, few agents have been identified... ...
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FePt nanoparticles as a potential X-ray activated chemotherapy agent for HeLa cells.International Journal of Nanomedicine (IF 7.033) Pub Date : 2015-11-26 ,DOI:10.2147/ijn.s88458Yanhong Zheng,Yunlan Tang,Zhirong Bao,Hui Wang,Feng Ren,Mingxiong Guo,Hong Quan,Changzhong Jiang
Nanomaterials have an advantage in "personalized" therapy, which is the ultimate goal of tumor treatment. In order to investigate the potential ability of FePt nanoparticles (NPs) in the diagnosis and chemoradiotherapy treatment of malignant tumors, superparamagnetic, monodispersed FePt (~3 nm) alloy NPs were synthesized, using cysteamine as a capping agent. The NPs were characterized by means of X-ray
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MicroRNA-720 promotes in vitro cell migration by targeting Rab35 expression in cervical cancer cells.Cell and Bioscience (IF 9.584) Pub Date : 2015-09-29 ,DOI:10.1186/s13578-015-0047-5Yunlan Tang,Yi Lin,Chuang Li,Xunwu Hu,Yi Liu,Mingyang He,Jun Luo,Guihong Sun,Tao Wang,Wenxin Li,Mingxiong Guo
BACKGROUND MicroRNA-720 (miR-720), a nonclassical miRNA, is involved in the initiation and progression of several tumors. In our previous studies, miR-720 was shown to be significantly upregulated in cervical cancer tissues compared with normal cervical tissues. However, the precise biological functions of miR-720, and its molecular mechanisms of action, are still unknown. RESULTS Microarray expression
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miR-638 regulates differentiation and proliferation in leukemic cells by targeting cyclin-dependent kinase 2.Journal of Biological Chemistry (IF 5.486) Pub Date : 2015 Jan 1 ,DOI:10.1074/jbc.m114.599191Yi Lin,Dengju Li,Qing Liang,Shangqing Liu,Xuelan Zuo,Lin Li,Xuemei Sun,Wenxin Li,Mingxiong Guo,Zan Huang
MicroRNAs have been extensively studied as regulators of hematopoiesis and leukemogenesis. We identified miR-638 as a novel regulator in myeloid differentiation and proliferation of leukemic cells. We found that miR-638 was developmentally up-regulated in cells of myeloid but not lymphoid lineage. Furthermore, significant miR-638 down-regulation was observed in primary acute myeloid leukemia (AML)
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The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60.Nature Communications (IF 17.694) Pub Date : 2015-Apr-1 ,DOI:10.1038/ncomms7752Hongmei Cui,Mingxiong Guo,Dong Xu,Zhi-Chun Ding,Gang Zhou,Han-Fei Ding,Junran Zhang,Yi Tang,Chunhong Yan
Tat-interactive protein 60 (Tip60) is a MYST histone acetyltransferase that catalyses acetylation of the major DNA damage kinase Ataxia telangiectasia mutated (ATM), thereby triggering cellular signalling required for the maintenance of genomic stability on genotoxic insults. The Tip60 activity is modulated by post-translational modifications that alter its stability and its interactions with substrates
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ZNF300 knockdown inhibits forced megakaryocytic differentiation by phorbol and erythrocytic differentiation by arabinofuranosyl cytidine in K562 cells.PLOS ONE (IF 3.752) Pub Date : 2014-12-09 ,DOI:10.1371/journal.pone.0114768Jinyang Cai,Rui Gong,Fengjuan Yan,Chunjie Yu,Lu Liu,Wei Wang,Yi Lin,Mingxiong Guo,Wenxin Li,Zan Huang
Previously, we reported that ZNF300 might play a role in leukemogenesis. In this study, we further investigated the function of ZNF300 in K562 cells undergoing differentiation. We found that ZNF300 upregulation in K562 cells coincided with megakaryocytic differentiation induced by phorbol-12-myristate-13-acetate (PMA) or erythrocytic differentiation induced by cytosine arabinoside (Ara-C), respectively
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Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins.PLOS ONE (IF 3.752) Pub Date : 2014-03-19 ,DOI:10.1371/journal.pone.0092155Wei Wang,Jinyang Cai,Yi Lin,Zikou Liu,Qihao Ren,Li Hu,Zan Huang,Mingxiong Guo,Wenxin Li
Multiple nuclear localization domains have been identified in nuclear proteins, and they finely control nuclear import and functions of those proteins. ZNF268 is a typical KRAB-containing zinc finger protein (KRAB-ZFP), and previous studies have shown that the KRAB domain reinforces nuclear localization of KRAB-ZFPs by interacting with KAP1. In this study, we find that some of 24 zinc fingers of ZNF268
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hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562.PLOS ONE (IF 3.752) Pub Date : 2013-12-26 ,DOI:10.1371/journal.pone.0084903Jian Ma,Youtian Hu,Mingxiong Guo,Zan Huang,Wenxin Li,Yingliang Wu
BACKGROUND The hERG potassium channel can modulate the proliferation of the chronic myelogenous leukemic K562 cells, and its role in the erythroid differentiation of K562 cells still remains unclear. PRINCIPAL FINDINGS The hERG potassium channel blockage by a new 36-residue scorpion toxin BmKKx2, a potent hERG channel blocker with IC50 of 6.7 ± 1.7 nM, enhanced the erythroid differentiation of K562
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Global expression profiling reveals genetic programs underlying the developmental divergence between mouse and human embryogenesis.BMC Genomics (IF 4.547) Pub Date : 2013-08-20 ,DOI:10.1186/1471-2164-14-568Lu Xue,Jin-Yang Cai,Jian Ma,Zan Huang,Ming-Xiong Guo,Lie-Zhen Fu,Yun-Bo Shi,Wen-Xin Li
BACKGROUND Mouse has served as an excellent model for studying human development and diseases due to its similarity to human. Advances in transgenic and knockout studies in mouse have dramatically strengthened the use of this model and significantly improved our understanding of gene function during development in the past few decades. More recently, global gene expression analyses have revealed novel
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Characterization of microRNA expression profiles and the discovery of novel microRNAs involved in cancer during human embryonic development.PLOS ONE (IF 3.752) Pub Date : 2013-08-02 ,DOI:10.1371/journal.pone.0069230Yi Lin,Yan Zeng,Fan Zhang,Lu Xue,Zan Huang,Wenxin Li,Mingxiong Guo
MicroRNAs (miRNAs), approximately 22-nucleotide non-coding RNA molecules, regulate a variety of pivotal physiological or pathological processes, including embryonic development and tumorigenesis. To obtain comprehensive expression profiles of miRNAs in human embryos, we characterized miRNA expression in weeks 4-6 of human embryonic development using miRNA microarrays and identified 50 human-embryo-specific
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Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1Cellular and Molecular Life Sciences (IF 9.207) Pub Date : 2013-05-12 ,DOI:10.1007/s00018-013-1359-4Wei Wang, Jinyang Cai, Yingliang Wu, Li Hu, Zongyun Chen, Jun Hu, Ze Chen, Wenxin Li, Mingxiong Guo, Zan HuangPreviously, we found that two isoforms of the ZNF268 gene (ZNF268a and ZNF268b2, with and without the KRAB domain, respectively) might play distinct roles in normal epithelia and in cervical cancer. Here we further investigated that KRAB domain defined the function disparity in part by reinforcing nuclear localization of ZNF268a. We found that the A-box of KRAB alone retained major specific nuclear ...
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Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.Cellular and Molecular Life Sciences (IF 9.207) Pub Date : 2013-05-12 ,DOI:10.1007/s00018-013-1359-4Wei Wang,Jinyang Cai,Yingliang Wu,Li Hu,Zongyun Chen,Jun Hu,Ze Chen,Wenxin Li,Mingxiong Guo,Zan HuangPreviously, we found that two isoforms of the ZNF268 gene (ZNF268a and ZNF268b2, with and without the KRAB domain, respectively) might play distinct roles in normal epithelia and in cervical cancer. Here we further investigated that KRAB domain defined the function disparity in part by reinforcing nuclear localization of ZNF268a. We found that the A-box of KRAB alone retained major specific nuclear ...
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Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells.Oncology Letters (IF 3.111) Pub Date : 2013-04-24 ,DOI:10.3892/ol.2013.1318Li Hu,Wei Wang,Jinyang Cai,Jun Luo,Yi Huang,Shilu Xiong,Wenxin Li,Mingxiong Guo
Ovarian cancer is one of the most lethal gynaecological cancers worldwide. However, the mechanisms underlying ovarian carcinogenesis are not well understood. The present study used immunostaining, western blotting and quantitative real-time PCR to demonstrate that ZNF268 is overexpressed in human ovarian carcinomas. ZNF268-knockdown increased the viability, colony formation and growth of in vivo xenografts
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