- 作 者: ( "xiaolian zhang" OR "xiao-lian zhang" )
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Intermittent fasting protects against food allergy in a murine model via regulating gut microbiotaFrontiers in Immunology (IF 8.786) Pub Date : 2023-05-09 ,DOI:10.3389/fimmu.2023.1167562Ru-xue Ma, Jia-qian Hu, Wei Fu, Jian Zhong, Can Cao, Chang-chang Wang, Shi-quan Qi, Xiao-Lian Zhang, Guang-hui Liu, Ya-dong Gao
BackgroundThe prevalence of food allergy (FA) is increasing. Decreases in the diversity of gut microbiota may contribute to the pathogenesis of FA by regulating IgE production of B cells. Intermittent fasting (IF) is a popular diet with the potential to regulate glucose metabolism, boosting immune memory and optimizing gut microbiota. The potential effect of long-term IF on the prevention and treatment
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Interleukin-16 genetic polymorphisms in Guangxi Chinese with hepatitis B virus-related liver cirrhosisMolecular Biology Reports (IF 2.742) Pub Date : 2023-05-03 ,DOI:10.1007/s11033-023-08450-0Xiaolian Zhang, Wenjun Tang, Xue Qin, Shan Li, Dong LiangBackground Our previous study has reported that interleukin-16 (IL-16) genetic polymorphisms are significantly related to chronic hepatitis B (CHB) and hepatitis B virus-related (HBV-related) hepatocellular carcinoma (HCC). As CHB, liver cirrhosis (LC), and HCC are development processes, this study aimed to determine genetic correlation of IL-16 polymorphisms with HBV-related LC in a Chinese population ...
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Bounding System-Induced Biases in Recommender Systems with a Randomized DatasetACM Transactions on Information Systems (IF 4.657) Pub Date : 2023-04-08 ,DOI:https://dl.acm.org/doi/10.1145/3582002Dugang Liu, Pengxiang Cheng, Zinan Lin, Xiaolian Zhang, Zhenhua Dong, Rui Zhang, Xiuqiang He, Weike Pan, Zhong MingDebiased recommendation with a randomized dataset has shown very promising results in mitigating system-induced biases. However, it still lacks more theoretical insights or an ideal optimization objective function compared with the other more well-studied routes without a randomized dataset. To bridge this gap, we study the debiasing problem from a new perspective and propose to directly minimize the ...
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Bounding System-Induced Biases in Recommender Systems with A Randomized DatasetarXiv - CS - Information Retrieval Pub Date : 2023-03-21 ,DOI:arxiv-2303.11574Dugang Liu, Pengxiang Cheng, Zinan Lin, Xiaolian Zhang, Zhenhua Dong, Rui Zhang, Xiuqiang He, Weike Pan, Zhong MingDebiased recommendation with a randomized dataset has shown very promising results in mitigating the system-induced biases. However, it still lacks more theoretical insights or an ideal optimization objective function compared with the other more well studied route without a randomized dataset. To bridge this gap, we study the debiasing problem from a new perspective and propose to directly minimize ...
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An Improved Over-Speed Deloading Control of Wind Power Systems for Primary Frequency Regulation Considering Turbulence CharacteristicsEnergies (IF 2.702) Pub Date : 2023-03-17 ,DOI:10.3390/en16062813Xiaolian Zhang, Baocong Lin, Ke Xu, Yangfei Zhang, Sipeng Hao, Qi Hu
Wind power systems participating in primary frequency regulation have become a novel trend. In order to solve the problem of the over-speed deloading (OSD) control of wind power systems failing to provide reserved capacity for primary frequency regulation while under turbulent winds, this paper analyzes the influence mechanism of turbulence characteristics on the OSD control and the relationship between
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The Transcriptome-Wide Mapping of 2-Methylthio-N6-isopentenyladenosine at Single-Base ResolutionJournal of the American Chemical Society (IF 16.383) Pub Date : 2023-02-23 ,DOI:10.1021/jacs.2c13894Zhentian Fang, Ziang Lu, Shaoqing Han, Yuanyuan Zhou, Wei Yang, Xiaolian Zhang, Xiang ZhouHundreds of modified bases have been identified and enzymatically modified to transfer RNAs (tRNAs) to regulate RNA function in various organisms. 2-Methylthio-N6-isopentenyladenosine (ms2i6A), a hypermodified base found at tRNA position 37, exists in both prokaryotes and eukaryotes. ms2i6A is traditionally identified by separating and digesting each tRNA from total RNA using RNA mass spectrometry ...
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Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against Sepsis (Adv. Mater. 6/2023)Advanced Materials (IF 32.086) Pub Date : 2023-02-09 ,DOI:10.1002/adma.202370041Ming-Yu Wu, Luojia Chen, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao-Lian Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen, Meijia GuSepsis Therapy ...
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Ti-Doped SnO2 Supports IrO2 Electrocatalysts for the Oxygen Evolution Reaction (OER) in PEM Water ElectrolysisACS Sustainable Chemistry & Engineering (IF 9.224) Pub Date : 2023-01-06 ,DOI:10.1021/acssuschemeng.2c06368Hanyang Li, Yuexin Xu, Ning Lv, Qiuyitong Zhang, Xiaolian Zhang, Zijie Wei, Yadong Wang, Haolin Tang, Hongfei PanThe development of polymer electrolyte membrane electrolysis of water is mainly limited by the high cost of noble metals and inadequate stability owing to the slow reaction kinetics of the oxygen evolution reaction and the restrictions of strongly acidic operating environments. To improve the utilization of noble metals, we use Ti-doped SnO2 as a carrier to support active species IrO2. The results ...
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Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against SepsisAdvanced Materials (IF 32.086) Pub Date : 2022-11-28 ,DOI:10.1002/adma.202208578Ming-Yu Wu, Luojia Chen, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao-Lian Zhang, Zhiqiang Li, Lianrong Wang, Shi Chen, Meijia GuSepsis, a widely recognized disease, is characterized by multiple pathogen infections. Therefore, it is imperative to develop methods that can efficiently identify and neutralize pathogen species. Phage cocktail therapy utilizes the host specificity of phages to adapt to infect resistant bacteria. However, its low sterilization stability efficiency and lack of imaging units seriously restrict its application ...
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Triplex Immunostrip Assay for Rapid Diagnosis of Tobacco Mosaic Virus, Tobacco Vein Banding Mosaic Virus, and Potato Virus YPlant Disease (IF 4.614) Pub Date : 2022-11-21 ,DOI:10.1094/pdis-08-21-1756-reYushuang Guo, Wei Wu, Xiaolian Zhang, Ming Ding, Jing Yu, Jie Zhang, Meng-ao Jia, Yanping TianMixed virus infection has increasingly become a problem in the production of Solanaceae crops in recent years; therefore, a fast and accurate detection method is needed. In this study, a novel triplex immunostrip assay was developed for the simultaneous detection of tobacco mosaic virus (TMV), tobacco vein banding mosaic virus (TVBMV), and potato virus Y (PVY). The limits of detection of this novel ...
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Cloning, characterization and functional analysis of NtMYB306a gene reveals its role in wax alkane biosynthesis of tobacco trichomes and stress tolerance.Frontiers in Plant Science (IF 6.627) Pub Date : 2022-10-06 ,DOI:10.3389/fpls.2022.1005811Jing Yu,Bo Lei,Huina Zhao,Bing Wang,Kaleem U Kakar,Yushuang Guo,Xiaolian Zhang,Mengao Jia,Hui Yang,Degang Zhao
Trichomes are specialized hair-like organs found on epidermal cells of many terrestrial plants, which protect plant from excessive transpiration and numerous abiotic and biotic stresses. However, the genetic basis and underlying mechanisms are largely unknown in Nicotiana tabacum (common tobacco), an established model system for genetic engineering and plant breeding. In present study, we identified
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EST12 regulates Myc expression and enhances anti-mycobacterial inflammatory response via RACK1-JNK-AP1-Myc immune pathway.Frontiers in Immunology (IF 8.786) Pub Date : 2022-08-08 ,DOI:10.3389/fimmu.2022.943174Jian Wu,Feng-Ling Luo,Yan Xie,Huan Xiong,Yadong Gao,Guanghui Liu,Xiao-Lian Zhang
c-Myc (Myc) is a well-known transcription factor that regulates many essential cellular processes. Myc has been implicated in regulating anti-mycobacterial responses. However, its precise mechanism in modulating mycobacterial immunity remains elusive. Here, we found that a secreted Rv1579c (early secreted target with molecular weight 12 kDa, named EST12) protein, encoded by virulent Mycobacterium tuberculosis
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Long Intergenic Non-Coding 00162 as Diagnostic Biomarker for Early-Stage Pancreatic Cancer.Annals of clinical and laboratory science Pub Date : 2022-07-01 ,DOI:Mingxing Chen,Yu Lu,Simeng Qin,Zuojian Hu,Huaping Chen,Liuyi Lu,Cuiju Mo,Xiaolian Zhang,Junhui Huang,Xue QinOBJECTIVE Pancreatic cancer (PC) is the fourth leading cause of cancer death due to insufficient diagnostic methods in early stage of PC. Growing evidence has shown that long intergenic non-coding RNAs (LINCRNAs) is a biomarker of the early-stage of PC. However, the expression level and diagnostic value of LINC00162 remains unclear. METHODS LINC00162 expression was detected in peripheral blood samples ...
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Lnc-EST12, which is negatively regulated by mycobacterial EST12, suppresses antimycobacterial innate immunity through its interaction with FUBP3Cellular & Molecular Immunology (IF 22.096) Pub Date : 2022-05-30 ,DOI:10.1038/s41423-022-00878-xQili Yao, Yan Xie, Dandan Xu, Zilu Qu, Jian Wu, Yuanyuan Zhou, Yuying Wei, Huan Xiong, Xiao-Lian Zhang
Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of intracellular pathogens. However, the role and mechanism of the important lncRNAs in Mycobacterium tuberculosis (M.tb) infection remain largely unexplored. Recently, we found that a secreted M.tb Rv1579c (an early secreted target with a molecular weight of 12 kDa, named EST12) protein activates NLRP3-gasdermin D (GSDMD)-mediated
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A Novel Frequency Control Method for Smart Buildings With Wind Power System Integration Considering Turbulence CharacteristicsIEEE Transactions on Industry Applications (IF 4.079) Pub Date : 2022-05-20 ,DOI:10.1109/tia.2022.3176259Xiaolian Zhang, Baocong Lin, Minghui Yin, Sipeng Hao, Chaohai Zhang, Tengjun ZuoFaced with the challenge of decarbonization, the net-zero smart building energy system with the integration of a wind power system could become one practical solution for people's energy usage, and a proper frequency control method is essential in helping realize the goal. This article studies the frequency control method of the net-zero smart building energy system adopting a wind power system where ...
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Host MKRN1-Mediated Mycobacterial PPE Protein Ubiquitination Suppresses Innate Immune Response.Frontiers in Immunology (IF 8.786) Pub Date : 2022-05-04 ,DOI:10.3389/fimmu.2022.880315Yafeng Dou,Yan Xie,Lingyun Zhang,Sheng Liu,Dandan Xu,Yuying Wei,Yongshuai Li,Xiao-Lian Zhang
Mycobacterium tuberculosis (Mtb), as an important intracellular pathogen, can invade and survive in macrophages and is capable of escaping the clearance of immune system. Despite decades of research efforts, the precise mechanism of immune escape and the virulence factors encoded by Mtb involved remain to be explored. Mtb-specific genomic regions of deletion (RD)-encoded proteins and PE/PPE family
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Atomistic explanation of failure mechanisms of thermoelectric type-VIII clathrate Ba8Ga16Sn30Materials Today Communications (IF 3.662) Pub Date : 2022-04-26 ,DOI:10.1016/j.mtcomm.2022.103605Xiaolian Zhang, Sergey I. Morozov, Zhongtao Lu, Xiege Huang, Wenjuan Li, Guodong Li, Pengcheng ZhaiThe type-VIII clathrate Ba8Ga16Sn30 (BGS) is a promising thermoelectric material with a cage-guest structure. The failure mechanisms behind the tetrahedrally bonded framework, which are vital for understanding the structure - mechanical property relationship, are still unrevealed. Here we conduct DFT calculations to investigate the intrinsic mechanical behavior of BGS. BGS has the ideal strength of ...
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Enhancement of mechanical properties of InSb through twin boundary engineeringScripta Materialia (IF 6.302) Pub Date : 2022-04-08 ,DOI:10.1016/j.scriptamat.2022.114734Zhongtao Lu, Pengcheng Zhai, Yongpeng Ran, Wenjuan Li, Xiaolian Zhang, Guodong LiTwin boundaries (TBs) have been found to be an effective strategy in enhancing mechanical properties of semiconductors. Our previous first principles study proved that TBs can raise the ideal strength of thermoelectric semiconducting InSb. In order to further optimize the mechanical properties of InSb, here we studied the role of TB orientation α, spacing λ, and doping in the strength and toughness ...
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Haploid induction in allotetraploid tobacco using DMPs mutationPlanta (IF 4.54) Pub Date : 2022-04-05 ,DOI:10.1007/s00425-022-03877-4Xiaolian Zhang, Lili Zhang, Jishun Zhang, Mengao Jia, Linggai Cao, Jing Yu, Degang ZhaoMain conclusion dmp1dmp2dmp3 mutants created by CRISPR/Cas9 could trigger maternal haploids in the allotetraploid model plant Nicotiana tabacum L. Abstract Double haploid (DH) technology is becoming increasingly important because it can significantly accelerate the breeding process. Haploid induction plays a fundamental role in the production of DH lines. Haploid induction has been realized and applied ...
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Abnormal ECA-Binding Membrane Glycans and Galactosylated CAT and P4HB in Lesion Tissues as Potential Biomarkers for Hepatocellular Carcinoma DiagnosisFrontiers in Oncology (IF 5.738) Pub Date : 2022-03-22 ,DOI:10.3389/fonc.2022.855952Ying Kong, Hao Chen, Mengyu Chen, Yongshuai Li, Jiarong Li, Qi Liu, Huan Xiong, Tangxi Guo, Yan Xie, Yufeng Yuan, Xiao-Lian Zhang
Hepatocellular carcinoma (HCC) is one of the most common types of cancer. Despite decades of research efforts, the search for novel biomarkers is still urgently needed for the diagnosis of HCC and the improvement of clinical outcomes. Previous studies of HCC clinical biomarkers have usually focused on serum and urine samples (e.g., serum Alpha-fetoprotein (AFP). However, cellular membrane proteins
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Types of Interferons and Their Expression in Plant SystemsJournal of Interferon & Cytokine Research (IF 3.657) Pub Date : 2022-02-14 ,DOI:10.1089/jir.2021.0148Linggai Cao, Lili Zhang, Xiaolian Zhang, Jia Liu, Meng-Ao Jia, Jishun Zhang, Jiemin Liu, Feng WangInterferons (IFNs) are divided into 3 types (type I, type II, and type III) on the basis of sequence homology and functional properties. Recombinant IFNs have been approved by regulatory agencies in many countries for clinical treatment of hepatitis B, hepatitis C, and other diseases; these IFNs are mainly produced in microorganisms and mammalian cell systems. However, there are serious obstacles to ...
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Types of Interferons and Their Expression in Plant Systems.Journal of Interferon & Cytokine Research (IF 3.657) Pub Date : 2022-02-01 ,DOI:10.1089/jir.2021.0148Linggai Cao,Lili Zhang,Xiaolian Zhang,Jia Liu,Meng-Ao Jia,Jishun Zhang,Jiemin Liu,Feng WangInterferons (IFNs) are divided into 3 types (type I, type II, and type III) on the basis of sequence homology and functional properties. Recombinant IFNs have been approved by regulatory agencies in many countries for clinical treatment of hepatitis B, hepatitis C, and other diseases; these IFNs are mainly produced in microorganisms and mammalian cell systems. However, there are serious obstacles to ...
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Enhancing the shear strength of single-crystalline In4Se3 through point defectsScripta Materialia (IF 6.302) Pub Date : 2022-01-12 ,DOI:10.1016/j.scriptamat.2022.114507Xiege Huang, Wenying Deng, Xiaolian Zhang, Sergey I. Morozov, Guodong Li, Pengcheng Zhai, Qingjie ZhangThe intrinsic shear strength (1.25 GPa) of In4Se3 remarkably lower than those of classic thermoelectric (TE) materials such as CoSb3 (7.17 GPa), PbTe (3.46 GPa), TiNiSn (10.52 GPa), which limits the commercial applications of In4Se3 based TE materials. To improve the shear strength of single-crystalline In4Se3, we used density functional theory to study the influence of point defects on the mechanical ...
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Deformation and Failure Mechanisms of Thermoelectric Type-I Clathrate Ba8Au6Ge40ACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2022-01-12 ,DOI:10.1021/acsami.1c22730Xiaolian Zhang, Pengcheng Zhai, Xiege Huang, Sergey I. Morozov, Bo Duan, Wenjuan Li, Gang Chen, Guodong Li, William A. Goddard, IIIType-I clathrate Ba8Au6Ge40, possessing an interesting structure stacked by polyhedrons, is a potential “phonon-glass, electron-crystal” thermoelectric material. However, the mechanical properties of Ba8Au6Ge40 vital for industrial applications have not been clarified. Here, we report the first density functional theory calculations of the intrinsic mechanical properties of thermoelectric clathrate ...
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A Novel Imidazolinone Derivative with 5-Arylidene and 2-Substituted Mercapto Group as Potent Anti-Hepatitis C Virus CompoundChemistry & Biodiversity (IF 2.745) Pub Date : 2021-12-19 ,DOI:10.1002/cbdv.202100602Ying Kong, Chongyang Mao, Shu Li, Yan Xie, Xiao-Lian Zhang, Boqiao FuHere six novel imidazolinone derivatives have been synthesized and the compound 4b containing 5-para-methoxy-phenylidene and 2-thioalkylation terminal substitution with 3’-cyano-2’,6’-dimethylphenyl showed the best anti-HCV activity and the lowest cytotoxicity. Selectivity index (SI=CC50/IC50) for the 4b was determined as 36, indicating that compound 4b was highly selective towards HCV. ...
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First-principle predictions of the electric and thermal transport performance on high-temperature thermoelectric semiconductor MnTe2Journal of Alloys and Compounds (IF 6.371) Pub Date : 2021-11-24 ,DOI:10.1016/j.jallcom.2021.162813Haoqin Ma, Houjiang Yang, Xiaolian Zhang, Bo Duan, Wenjuan Li, Pengcheng Zhai, Guodong LiAntiferromagnetic pyrite compound MnTe2 is a newly discovered high-performance thermoelectric material. However, its electric and thermal transport performance remained unexplored so far. In this work, the first-principle calculations based on the density functional theory were applied to predict the electric and thermal transport performance of MnTe2. The band structures showed that Te atoms dominate ...
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A New Reference Plasmid “pGMT27” Provides an Efficient Transgenic Detection Method for Flue-Cured TobaccoJournal of Food Quality (IF 3.2) Pub Date : 2021-11-15 ,DOI:10.1155/2021/3220013Jing Yu, Xiaolian Zhang, Muhammad Faheem Adil, Bo Lei, Mengao Jia, Huina Zhao, Shizhou Yu, Jiemin Liu, Yushuang Guo, Imran Haider Shamsi
Owing to the economic value of its foliage, tobacco (Nicotiana tabacum) is cultivated all across the world. For the detection of genetically modified (GM) tobacco, there is a lack of universal standard material which ultimately limits the detection methods because the accuracy and comparability of the results cannot be ensured. Here, we prepared a reference plasmid “pGMT27” for the detection of GM
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Controllable dimensions and regular geometric architectures from self-assembly of lithium-containing polyhedral oligomeric silsesquioxane: Build for enhancing the fire safety of epoxy resinComposites Part B: Engineering (IF 11.322) Pub Date : 2021-11-12 ,DOI:10.1016/j.compositesb.2021.109483Xinming Ye, Xiaolian Zhang, Yunyun Jiang, Liang Qiao, Wenchao Zhang, Ye-Tang Pan, Rongjie Yang, Jiarong Li, Yingchun LiMitigating the fire hazards of epoxy resin (EP) and simultaneously improving mechanical properties have always been a goal pursued by polymeric scientists. Herein, we prepared a lithium-containing hepta-isobutyl-POSS (ibu-T7-Li-POSS). The chemical structure of ibu-T7-Li-POSS was well characterized. Just via tuning the ethanol solution concentration, we can obtain zero-dimensional (0D) spherical nanoparticles ...
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Development of Near-Infrared Nucleic Acid Mimics of Fluorescent Proteins for In Vivo Imaging of Viral RNA with Turn-On FluorescenceJournal of the American Chemical Society (IF 16.383) Pub Date : 2021-11-11 ,DOI:10.1021/jacs.1c04577Jiaheng Zhang, Huiyi Li, Bin Lin, Xingyu Luo, Peng Yin, Ting Yi, Binbin Xue, Xiao-Lian Zhang, Haizhen Zhu, Zhou NieGFP-like fluorescent proteins and their molecular mimics have revolutionized bioimaging research, but their emissions are largely limited in the visible to far-red region, hampering the in vivo applications in intact animals. Herein, we structurally modulate GFP-like chromophores using a donor–acceptor–acceptor (D–A–A′) molecular configuration to discover a set of novel fluorogenic derivatives with ...
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The influence of twin boundary on lattice thermal conductivity of thermoelectric InSbApplied Physics Letters (IF 3.971) Pub Date : 2021-10-18 ,DOI:10.1063/5.0068007Yongpeng Ran, Zhongtao Lu, Xiaolian Zhang, Wenjuan Li, Bo Duan, Pengcheng Zhai, Guodong Li
Twin boundaries (TBs) can increase interface scattering to reduce the lattice thermal conductivity. InSb has good electronic transport properties, but its high thermal conductivity constrains its thermoelectric application. In this work, we aim to study the role of TBs on lattice thermal conductivity of InSb. We use non-equilibrium molecular dynamics simulation to investigate how the TB spacing and
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