- 作 者: "wei wang"
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Neuronal nitric oxide synthase/reactive oxygen species pathway is involved in apoptosis and pyroptosis in epilepsyNeural Regeneration Research (IF 6.058) Pub Date : 2023-06-01 ,DOI:10.4103/1673-5374.357906Xiao-Xue Xu, Rui-Xue Shi, Yu Fu, Jia-Lu Wang, Xin Tong, Shi-Qi Zhang, Na Wang, Mei-Xuan Li, Yu Tong, Wei Wang, Miao He, Bing-Yang Liu, Gui-Lan Chen, Feng Guo
Dysfunction of neuronal nitric oxide synthase contributes to neurotoxicity, which triggers cell death in various neuropathological diseases, including epilepsy. Studies have shown that inhibition of neuronal nitric oxide synthase activity increases the epilepsy threshold, that is, has an anticonvulsant effect. However, the exact role and potential mechanism of neuronal nitric oxide synthase in seizures
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A Numerical Study on Mechanical Effects of Low-Intensity Pulsed Ultrasound on Trabecular Bone and Osteoblasts.Journal of Biomechanical Engineering Pub Date : 2023-05-01 ,DOI:10.1115/1.4056658Congbiao Tian,Haiying Liu,Chaohui Zhao,Chunqiu Zhang,Wei WangThe lack of sufficient mechanical stimulation to the human bone, results in disuse osteoporosis. Low-intensity pulsed ultrasound (LIPUS) promotes fracture healing and the treatment of disuse osteoporosis, but its biomechanical mechanism remains unknown. Simulative research on the mechanical effects of LIPUS on disuse trabecular bone and osteoblasts have been performed. The von Mises stress of disuse ...
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Blunt dopamine transmission due to decreased GDNF in the PFC evokes cognitive impairment in Parkinson's disease.Neural Regeneration Research (IF 6.058) Pub Date : 2023-05-01 ,DOI:10.4103/1673-5374.355816Chuan-Xi Tang,Jing Chen,Kai-Quan Shao,Ye-Hao Liu,Xiao-Yu Zhou,Cheng-Cheng Ma,Meng-Ting Liu,Ming-Yu Shi,Piniel Alphayo Kambey,Wei Wang,Abiola Abdulrahman Ayanlaja,Yi-Fang Liu,Wei Xu,Gang Chen,Jiao Wu,Xue Li,Dian-Shuai Gao
Studies have found that the absence of glial cell line-derived neurotrophic factor may be the primary risk factor for Parkinson's disease. However, there have not been any studies conducted on the potential relationship between glial cell line-derived neurotrophic factor and cognitive performance in Parkinson's disease. We first performed a retrospective case-control study at the Affiliated Hospital
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High expression of SDC1 in stromal cells is associated with good prognosis in colorectal cancerAnti-Cancer Drugs (IF 2.389) Pub Date : 2023-04-01 ,DOI:10.1097/cad.0000000000001441Zhejie Li, Shujin He, Jianli Liu, Xiao Zhi, Lili Yang, Junjun Zhang, Ran Zhao, Renya Zhang, Lei Li, Wei WangWe have previously reported that patients with high Syndecan 1 (SDC1) expression in colorectal cancer (CRC) cells have a favorable prognosis, and we also found that stromal cells showed upregulation of SDC1, but the clinical significance is unclear. The expression of SDC1 in the stroma cells was assessed by immunohistochemistry using a tissue microarray comprising representative cores from 513 CRC ...
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Retinal age gap as a predictive biomarker for mortality riskBritish Journal of Ophthalmology (IF 5.908) Pub Date : 2023-04-01 ,DOI:10.1136/bjophthalmol-2021-319807Zhuoting Zhu, Danli Shi, Peng Guankai, Zachary Tan, Xianwen Shang, Wenyi Hu, Huan Liao, Xueli Zhang, Yu Huang, Honghua Yu, Wei Meng, Wei Wang, Zongyuan Ge, Xiaohong Yang, Mingguang HeAim To develop a deep learning (DL) model that predicts age from fundus images (retinal age) and to investigate the association between retinal age gap (retinal age predicted by DL model minus chronological age) and mortality risk. Methods A total of 80 169 fundus images taken from 46 969 participants in the UK Biobank with reasonable quality were included in this study. Of these, 19 200 fundus images ...
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Neoadjuvant Chemotherapy With CAPOX Versus Chemoradiation for Locally Advanced Rectal Cancer With Uninvolved Mesorectal Fascia (CONVERT): Initial Results of a Phase III TrialAnnals of Surgery (IF 13.787) Pub Date : 2023-04-01 ,DOI:10.1097/sla.0000000000005780Wei-Jian Mei, Xiao-Zhong Wang, Yun-Feng Li, Yue-Ming Sun, Chun-Kang Yang, Jun-Zhong Lin, Zu-Guang Wu, Rui Zhang, Wei Wang, Yong Li, Ye-Zhong Zhuang, Jian Lei, Xiang-Bin Wan, Ying-Kun Ren, Yong Cheng, Wen-Liang Li, Zi-Qiang Wang, Dong-Bo Xu, Xian-Wei Mo, Hai-Xing Ju, Sheng-Wei Ye, Jing-Lin Zhao, Hong Zhang, Yuan-Hong Gao, Zhi-Fan Zeng, Wei-Wei Xiao, Xiao-Peng Zhang, Xuan Zhang, E Xie, Yi-Fei Feng, Jing-Hua
Objective: To compare neoadjuvant chemotherapy (nCT) with CAPOX alone versus neoadjuvant chemoradiotherapy (nCRT) with capecitabine in locally advanced rectal cancer (LARC) with uninvolved mesorectal fascia (MRF). Background Data: nCRT is associated with higher surgical complications, worse long-term functional outcomes, and questionable survival benefits. Comparatively, nCT alone seems a promising
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Component model and design method for tensile behavior of slip-critical blind bolts anchored in concrete-filled steel tubular sectionsThin-Walled Structures (IF 5.881) Pub Date : 2023-03-24 ,DOI:10.1016/j.tws.2023.110701Xing Gao, Wei WangThis paper derives a component model to capture the tensile behavior of concrete-anchored slip-critical blind bolt (CASCBB) anchored in concrete-filled steel tubular sections (CFSTS). CASCBB is developed based on a rare blind bolting system which can achieve the same pre-tension as the conventional high strength bolts, i.e. SCBB, good for enhancing the stiffness and seismic performance of joints. Based ...
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Tribological properties of lyophilized graphene loading nano-copper as lubricating oil additiveIndustrial Lubrication and Tribology (IF 1.442) Pub Date : 2023-03-24 ,DOI:10.1108/ilt-08-2022-0254Runling Peng, Jinyue Liu, Wei Wang, Peng Wang, Shijiao Liu, Haonan Zhai, Leyang Dai, Junde GuoPurpose This study aims to investigate the synergistic friction reduction and antiwear effects of lyophilized graphene loading nano-copper (RGO/Cu) as lubricating oil additives, compared with graphene. Design/methodology/approach The friction performance of freeze-drying graphene (RGO) and RGO/Cu particles was investigated at different addition concentrations and under different conditions. Findings ...
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Digital Economy and 3E Efficiency Performance: Evidence from EU CountriesSustainability (IF 3.889) Pub Date : 2023-03-23 ,DOI:10.3390/su15075661Shuangjie Li, Wei Wang, Liming Wang, Ge WangNowadays, sustainability has become an important and widely accepted concept. Energy conservation and emission reduction are closely related to sustainable economic development. Therefore, a 3E efficiency approach, based on the “Energy–Environmental–Economic” (3E) system, can assess the coordination relationships among these three factors from the perspective of energy conservation and emission reduction ...
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Inhibitory Activities of Samples on Tyrosinases Were Affected by Enzyme Species and Sample Addition MethodsInternational Journal of Molecular Sciences (IF 6.208) Pub Date : 2023-03-23 ,DOI:10.3390/ijms24076013Wei Wang, Lijuan Yang, Weiwei Wang, Jianyong Zhang, Ulrich H. Engelhardt, Heyuan JiangThe inhibition of tyrosinase (TYR) activity is an effective measure to inhibit melanin synthesis. At present, there are many methods with discrepant details that study the TYR inhibitory activity of samples. Under the same experimental conditions, this paper systematically studies whether enzyme species and sample addition methods are the key factors that determine the TYR inhibitory activity of samples ...
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The genome of medicinal plant Sophora flavescens has undergone significant expansion of both transposons and genes.bioRxiv - Genomics Pub Date : 2023-03-23 ,DOI:10.1101/2023.03.20.533393Zhipeng Qu, Wei Wang, David L Adelson
Purpose: Sophora flavescens is a medicinal plant in the genus Sophora of the Fabaceae family. The root of S. flavescens is known in China as Kushen and has a long history of wide use in multiple formulations of Traditional Chinese Medicine (TCM). However, there is little genomic information available for S. flavescens. Methods: In this study, we used third-generation Nanopore long-read sequencing technology
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Research progress of catalysts for aldol condensation of biomass based compoundsRSC Advances (IF 4.036) Pub Date : 2023-03-23 ,DOI:10.1039/d3ra00906hXing Zhang, YanQing Li, Chi Qian, Ling An, Wei Wang, XiuFeng Li, XianZhao Shao, Zhizhou LiResearch progress of catalysts of the aldol condensation reaction of biomass based compounds is summarized for the synthesis of liquid fuel precursors and chemicals. In summary, an acidic catalyst, alkaline catalyst, acid–base amphoteric catalyst, ionic liquid and other catalysts can catalyze the aldol condensation reaction. The aldol condensation reaction catalyzed by an acid catalyst has the problems ...
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A Porous π-Stacked Self-Assembly of Cup-Shaped Palladium Complex for Iodine CaptureMolecules (IF 4.927) Pub Date : 2023-03-23 ,DOI:10.3390/molecules28072881Lin-Lin Li, Min Huang, Ting Chen, Xiao-Feng Xu, Zhu Zhuo, Wei Wang, You-Gui HuangAcquiring adsorbents capable of effective radioiodine capture is important for nuclear waste treatment; however, it remains a challenge to develop porous materials with high and reversible iodine capture. Herein, we report a porous self-assembly constructed by a cup-shaped PdII complex through intermolecular π···π interactions. This self-assembly features a cubic structure with channels along all three ...
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Breast Tumor Classification using Short-ResNet with Pixel-based Tumor Probability Map in Ultrasound ImagesUltrasonic Imaging (IF 2.0) Pub Date : 2023-03-23 ,DOI:10.1177/01617346231162906You-Wei Wang, Tsung-Ter Kuo, Yi-Hong Chou, Yu Su, Shing-Hwa Huang, Chii-Jen ChenBreast cancer is the most common form of cancer and is still the second leading cause of death for women in the world. Early detection and treatment of breast cancer can reduce mortality rates. Bre... ...
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Role of Systemic Immunoinflammation Landscape in the Overall Survival of Patients with Leptomeningeal Metastases from Lung CancerOncoTargets and Therapy (IF 4.345) Pub Date : 2023-03-23 ,DOI:10.2147/ott.s402389Jia-Wei Wang, Qing Yuan, Li Li, Kai-Hua Cao, Qi Liu, Hong-Liang Wang, Ke Hu, Xi Wu, Jing-Hai WanPurpose: Several biomarkers, such as baseline neutrophil-to-lymphocyte ratio (NLR), have been more investigated in patients with brain metastases (BM), while their role in patients with leptomeningeal metastases (LM) has not been clarified. Considering the difference between the clinical behaviour of BM and LM, there is the need for addressing the role of these biomarkers in LM. Methods: The present ...
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Research on process modeling and simulation of spent lead paste desulfurization enhanced reactorChinese Journal of Chemical Engineering Pub Date : 2023-03-23 ,DOI:10.1016/j.cjche.2023.02.025Lijuan Zhao, Zhe Tan, Xiaoguang Zhang, Qijun Zhang, Wei Wang, Qiang Deng, Jie Ma, De'an PanIn the reaction process of carbonate desulfurization lead paste, the produced PbCO3 is easily wrapped in the outer periphery of PbSO4 to form a product layer, hindering the mass transfer process. Therefore, it is necessary to break the PbCO3 product layer. In this work, the rotor stator-reinforced reactor (RS-RR) was selected as the enhanced desulfurization reactor for the purpose of breaking the PbCO3 ...
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A new approach: Evaluation of necroptosis and immune status enables prediction of the tumor microenvironment and treatment targets in pancreatic cancerComputational and Structural Biotechnology Journal (IF 6.155) Pub Date : 2023-03-23 ,DOI:10.1016/j.csbj.2023.03.037Si-Yuan Lu, Jie Hua, Jiang Liu, Miao-Yan Wei, Chen Liang, Qing-Cai Meng, Bo Zhang, Xian-Jun Yu, Wei Wang, Jin Xu, Si ShiGrowing evidence indicates a potential correlation between necroptosis and pancreatic cancer, and the relationship between necroptosis, immune infiltration and the microenvironment in pancreatic cancer has drawn increasing attention. However, two-dimensional phenotype and prognostic assessment systems based on a combination of necroptosis and immunity have not been explored. In our present study, we ...
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Changes of serum NSE, lactate and CRP in patients with postoperative infection after acute craniocerebral injury and their predictive value for prognosisBiotechnology and Genetic Engineering Reviews (IF 4.2) Pub Date : 2023-03-22 ,DOI:10.1080/02648725.2023.2191067Kegao Ma, Zhentong Liu, Wei WangABSTRACT To investigate the changes of serum neuron-specific enolase (NSE), lactate and C-reactive protein (CRP) in patients with postoperative infection after acute craniocerebral injury and their predictive value for prognosis. 71 patients with postoperative infection after acute craniocerebral injury were selected as infection group, and 56 patients without postoperative infection were selected ...
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Robust Optimal Investment Strategies with Exchange Rate Risk and Default RiskMathematics (IF 2.592) Pub Date : 2023-03-22 ,DOI:10.3390/math11061550Wei Wang, Qianyan Li, Quan Li, Song XuThe problem of robust optimal investment with exchange rate risk and default risk is studied. We assume that investors are ambiguity averse and they have access not only to the domestic market but also to the foreign market. The corresponding Hamilton–Jacobi–Bellman (HJB) equations are first obtained through the robust stochastic optimal control theory. Then, we discuss the optimal investment problems ...
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Life-cycle benefits estimation of self-centering building structuresEngineering Structures (IF 5.582) Pub Date : 2023-03-22 ,DOI:10.1016/j.engstruct.2023.115982Shuling Hu, Wei Wang, M. Shahria Alam, Ke KeVarious self-centering structural systems were developed and investigated for reducing residual inter-story drifts of the traditional aseismic structural system by achieving full or partial self-centering behaviors under earthquakes in the past twenty years. However, limited research was conducted to investigate the life-cycle benefits of the full and partial self-centering structural systems on the ...
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Impact of high-speed railway construction on spatial patterns of regional economic development along the route: A case study of the Shanghai–Kunming high-speed railwaySocio-Economic Planning Sciences (IF 4.641) Pub Date : 2023-03-22 ,DOI:10.1016/j.seps.2023.101583Chao Wang, Junjing Chen, Boyan Li, Nengcheng Chen, Wei WangThe Shanghai–Kunming high-speed railway spans the eastern, central, and western regions of China and is an important "horizontal" in the "eight vertical and eight horizontal" railway network of China. This paper estimates the direct impact of opening a high-speed railway on the spatial patterns of regional economic development along the route by integrating GIS technology, spatial panel data models ...
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Coordination strategy to prepare high-performance Fe-Nx catalysts for Al-air batteriesJournal of Power Sources (IF 9.794) Pub Date : 2023-03-22 ,DOI:10.1016/j.jpowsour.2023.232988Xu Meng, Xuemeng Zhang, Justin Rageloa, Zigeng Liu, Wei WangOxygen reduction reaction (ORR) is the core reaction of energy conversion devices, such as proton exchange membrane fuel cells and Al-air batteries. Thus, there is an urgent demand for efficient and stable electrocatalysts to accelerate the ORR process. In this study, we present a novel method for preparing Fe-Nx catalysts through the use of electrospinning technology. The catalyst has a one-dimensional ...
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On the evolution of supercavity geometry and unsteady behavior of supercavitation flow during the development of a twin-vortex supercavityOcean Engineering (IF 4.372) Pub Date : 2023-03-22 ,DOI:10.1016/j.oceaneng.2023.114213Haiyu Xu, Cong Wang, Yingjie Wei, Wei Cao, Wei WangTo investigate the evolution of supercavity geometry and the unsteady characteristics of the supercavitation flow from the initial generation to full development. A three-dimensional numerical model with the inhomogeneous multiphase model and SST k−ω turbulence model was established. The numerical model was validated by experimental results. The ventilated supercavitation flow was performed under the ...
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The WAVE3/β-catenin oncogenic signaling regulates chemoresistance in triple negative breast cancerBreast Cancer Research (IF 8.408) Pub Date : 2023-03-22 ,DOI:10.1186/s13058-023-01634-3Wei Wang, Priyanka S. Rana, Vesna Markovic, Khalid Sossey-AlaouiMetastatic breast cancer is responsible for the death of the majority of breast cancer patients. In fact, metastatic BC is the 2nd leading cause of cancer-related deaths in women in the USA and worldwide. Triple negative breast cancer (TNBC), which lacks expression of hormone receptors (ER-α and PR) and ErbB2/HER2, is especially lethal due to its highly metastatic behavior, propensity to recur rapidly ...
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Inhibitory effects and mechanisms of proanthocyanidins against enterovirus 71 infectionVirus Research (IF 6.286) Pub Date : 2023-03-22 ,DOI:10.1016/j.virusres.2023.199098Jiqin Sun, Xiaoyao Ma, Lishan Sun, Yang Zhang, Cui Hao, Wei Wang
Proanthocyanidins (PC), a natural flavonoid compound, was reported to possess a variety of pharmacological activities such as anti-tumor and anti-viral effects. In this study, the anti-Enterovirus 71 (EV71) activities and mechanisms of PC were investigated both in vitro and in vivo. The results showed that PC possessed anti-EV71 activities in different cell lines with low toxicity. PC can block both
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Simulation and Analysis of the Influence of Sounding Rocket Outgassing on In-Situ Atmospheric DetectionAtmosphere (IF 3.11) Pub Date : 2023-03-22 ,DOI:10.3390/atmos14030603Zhiliang Zhang, Yueqiang Sun, Yongping Li, Jiangzhao Ai, Xiaoliang Zheng, Wei WangThe Meridian Project’s sounding rocket mission uses a mass spectrometer to conduct in-situ atmospheric detection. In order to assess the influence of surface material outgassing and the attitude control jet on the spectrometer’s detection, a sounding rocket platform was modeled and simulated. Using the physical field simulation software COMSOL and the Monte Carlo method, this study investigated whether ...
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Inhibition of PINK1-Mediated Mitophagy Contributes to Postoperative Cognitive Dysfunction through Activation of Caspase-3/GSDME-Dependent PyroptosisACS Chemical Neuroscience (IF 5.78) Pub Date : 2023-03-22 ,DOI:10.1021/acschemneuro.2c00691Wei Wang, Bo Zhao, Wenwei Gao, Wenqin Song, Jiabao Hou, Lei Zhang, Zhongyuan XiaPTEN-induced kinase 1 (PINK1)-mediated mitophagy and caspase-1/gasdermin D canonical pyroptosis pathways have been implicated in the pathogenesis of postoperative cognitive dysfunction (POCD). However, gasdermin E (GSDME), another recently identified executioner of pyroptosis that can be specifically cleaved by caspase-3, is highly expressed in the brain and neurons. This study aimed to ascertain whether ...
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Sudden unexpected death from subvalvular hemorrhagic cyst complicated with coronary heart disease in an adultForensic Science, Medicine and Pathology (IF 2.456) Pub Date : 2023-03-22 ,DOI:10.1007/s12024-023-00614-5Yanjie Ding, Wei Wang, Qiufeng Tan, Shilin Zhang, Xiao Zhang, Bo Jin, Ying XieCardiac blood cysts are rare benign tumors. It is commonly found in the heart valve and left ventricle of newborns by autopsy and is rarely seen in adults [1, 2]. The typical histopathology of cardiac blood cysts is a closed, round, blood-containing cystic mass attached to the heart valve or endocardium. This article reports a rare case of sudden death due to a giant subaortic cardiac blood cyst with ...
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Privacy-preserving identification of the influential nodes in networksInternational Journal of Modern Physics C (IF 1.353) Pub Date : 2023-03-22 ,DOI:10.1142/s0129183123501280Jia-Wei Wang, Hai-Feng Zhang, Xiao-Jing Ma, Jing Wang, Chuang Ma, Pei-Can ZhuIdentifying influential nodes in social networks has drawn significant attention in the field of network science. However, most of the existing works request to know the complete structural information about networks, indeed, this information is usually sensitive, private and hard to obtain. Therefore, how to identify the influential nodes in networks without disclosing privacy is especially important ...
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Preoperative posterior tilt can be a risk factor of fixation failure in nondisplaced femoral neck fracture: a systematic review and meta-analysisEuropean Journal of Orthopaedic Surgery & Traumatology Pub Date : 2023-03-22 ,DOI:10.1007/s00590-023-03518-wWei Wang, Zhifeng Huang, Jing Peng, Jun Fan, Xiaotao LongPurpose This systematic review and meta-analysis aimed to identify whether posterior tilt increases the risk of treatment failure in nondisplaced femoral neck fractures. Methods We searched the databases of the PubMed, Embase, and Cochrane Library from 1980 to 2022. The search strategy was based on the combination of keywords “nondisplaced,” “hip fracture,” “femoral neck fracture,” and “internal fixation ...
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