- 作 者: ( "jianjun chu" OR "jian-jun chu" )
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Preparation of new bio-based antibacterial acrylic bone cement via modification with a biofunctional monomer of nitrofurfuryl methacrylatePolymer Chemistry (IF 5.364) Pub Date : 2022-07-14 ,DOI:10.1039/d2py00235cJianjun Chu, Chuang Li, Jing Guo, Yang Xu, Yao FuPolymethyl methacrylate (PMMA) bone cement is a commonly used filling material in orthopedic surgery. Its excellent performance, such as convenient handling and rapid self-hardening features, makes it the most widely used bone cement. With the advancement of the application and research of PMMA bone cement by surgeons, some disadvantages such as non-degradation, non-bioactivity and poor antibacterial ...
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Architecture entropy sampling-based evolutionary neural architecture search and its application in osteoporosis diagnosisComplex & Intelligent Systems (IF 6.7) Pub Date : 2022-06-25 ,DOI:10.1007/s40747-022-00794-7Jianjun Chu, Xiaoshan Yu, Shangshang Yang, Jianfeng Qiu, Qijun Wang
In recent years, neural architecture search (NAS) has achieved unprecedented development because of its ability to automatically achieve high-performance neural networks in various tasks. Among these, the evolutionary neural architecture search (ENAS) has impressed the researchers due to the excellent heuristic exploration capability. However, the evolutionary algorithm-based NAS are prone to the loss
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Building and training a deep spiking neural network for ECG classificationBiomedical Signal Processing and Control (IF 5.076) Pub Date : 2022-05-02 ,DOI:10.1016/j.bspc.2022.103749Yifei Feng, Shijia Geng, Jianjun Chu, Zhaoji Fu, Shenda HongThe electrocardiogram (ECG) reflects the electrical activity of the heart, and is one the most widely used biophysical signals that evaluate heart-related conditions. With years of experiences, medical professionals are able to identify and classify various ECG patterns. However, manually classifying ECG signals is prone to errors and takes considerable amount of time and effort, and thus people start ...
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Analysis of risk factors for perioperative hidden blood loss in patients undergoing transforaminal lumbar interbody fusion.Journal of International Medical Research (IF 1.573) Pub Date : 2020-08-10 ,DOI:10.1177/0300060520937848Rui Zhang,Fei Xing,Zhuqing Yang,Guoxiong Lin,Jianjun Chu
Objective This study was performed to analyze the correlation between perioperative hidden blood loss (HBL) and the general condition of patients undergoing transforaminal lumbar interbody fusion (TLIF). Methods We retrospectively analyzed patients who underwent TLIF from July 2017 to July 2019 in our hospital. Sex, age, body mass index, underlying diseases, American Society of Anesthesiologists classification
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Bright Fluorescent Vacuolar Marker Lines Allow Vacuolar Tracing Across Multiple Tissues and Stress Conditions in RiceInternational Journal of Molecular Sciences (IF 4.556) Pub Date : 2020-06-12 ,DOI:10.3390/ijms21124203Yiran Cao, Wenguo Cai, Xiaofei Chen, Mingjiao Chen, Jianjun Chu, Wanqi Liang, Staffan Persson, Zengyu Liu, Dabing Zhang
The vacuole is indispensable for cells to maintain their water potential and to respond to environmental changes. Nevertheless, investigations of vacuole morphology and its functions have been limited to Arabidopsis thaliana with few studies in the model crop rice (Oryza sativa). Here, we report the establishment of bright rice vacuole fluorescent reporter systems using OsTIP1;1, a tonoplast water
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Bright Fluorescent Vacuolar Marker Lines Allow Vacuolar Tracing Across Multiple Tissues and Stress Conditions in Rice.International Journal of Molecular Sciences Pub Date : 2020-06-12 ,DOI:10.3390/ijms21124203Yiran Cao,Wenguo Cai,Xiaofei Chen,Mingjiao Chen,Jianjun Chu,Wanqi Liang,Staffan Persson,Zengyu Liu,Dabing Zhang
The vacuole is indispensable for cells to maintain their water potential and to respond to environmental changes. Nevertheless, investigations of vacuole morphology and its functions have been limited to Arabidopsis thaliana with few studies in the model crop rice (Oryza sativa). Here, we report the establishment of bright rice vacuole fluorescent reporter systems using OsTIP1;1, a tonoplast water
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The Efficacy of Immersive Virtual Reality Surgical Simulator Training for Pedicle Screw Placement: A Randomized Double-Blind Controlled Trial.World Neurosurgery (IF 2.21) Pub Date : 2019-01-01 ,DOI:10.1016/j.wneu.2018.12.090Baoquan Xin,Guanghui Chen,Yang Wang,Guangjian Bai,Xin Gao,Jianjun Chu,Jianru Xiao,Tielong LiuPURPOSE To assess efficacy of immersive virtual reality (VR) surgical simulator training for pedicle screw placement (PSP) in surgical graduate students. METHODS Sixteen inexperienced surgical graduate students were equally randomly assigned to an experimental group (VR group) and a control group (non-VR group). Students in the VR group performed PSP on the immersive VR surgical simulator, and students ...
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Liriodenine enhances radiosensitivity in esophageal cancer ECA-109 cells by inducing apoptosis and G2/M arrest.Oncology Letters (IF 3.111) Pub Date : 2018-09-27 ,DOI:10.3892/ol.2018.9253Gang Wu,Guangzong Chen,Jialiang Zhou,Hongcheng Zhu,Jianjun Chu,Fuzheng Zhang
At present, chemotherapy and radiotherapy represent the primary modalities of treatment for patients with unresectable esophageal squamous cell carcinoma (ESCC). However, the outcome of patients remains poor owing to radioresistance. The present study aimed to determine the radiosensitizing effect of liriodenine, an aporphine alkaloid derived from Enicosanthellum pulchrum, and investigating the underlying
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Effective segmentations in white blood cell images using \(\epsilon \)-SVR-based detection methodNeural Computing and Applications (IF 5.102) Pub Date : 2018-05-02 ,DOI:10.1007/s00521-018-3480-7Feilong Cao,Yuehua Liu,Zhen Huang,Jianjun Chu,Jianwei ZhaoWhite blood cell (WBC) image detection plays an important role in automatic morphological systems since it can simplify and facilitate WBC segmentation and classification procedures. However, existing WBC detection methods mainly rely on the location of the nucleus, which is found difficult to achieve accurate detection results. This paper proposes a novel WBC detection algorithm through sliding windows ...
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Intensity-modulated radiotherapy plus nimotuzumab with or without concurrent chemotherapy for patients with locally advanced nasopharyngeal carcinoma.OncoTargets and Therapy (IF 4.345) Pub Date : 2017-12-08 ,DOI:10.2147/ott.s151554Jianfeng Huang,Qinzhou Zou,Danqi Qian,Leyuan Zhou,Bo Yang,Jianjun Chu,Qingfeng Pang,Kewei Wang,Fuzheng Zhang
OBJECTIVE This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). PATIENTS AND METHODS A total of 50 newly diagnosed patients with LA-NPC treated at the Affiliated Hospital of Jiangnan University between November 2011 and January
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iTRAQ-based quantitative proteomics reveals the biochemical mechanism of cold stress adaption of razor clam during controlled freezing-point storageFood Chemistry (IF 9.231) Pub Date : 2017-12-05 ,DOI:10.1016/j.foodchem.2017.12.004Chong Wang,Jianjun Chu,Linglin Fu,Yanbo Wang,Feng Zhao,Deqing ZhouRazor clam is a major cultivated shellfish of great economic importance and high nutritional value. Due to high corruptible potential, razor clam is generally preserved by controlled freezing-point storage (CFPS). Here, we applied isobaric tags for relative and absolute quantification (iTRAQ) labeling to investigate the biochemical mechanism of cold stress adaption in razor clam during CFPS. In total ...
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Segmentation of White Blood Cells Image Using Adaptive Location and IterationIEEE Journal of Biomedical and Health Informatics (IF 7.021) Pub Date : 2017-11-01 ,DOI:10.1109/jbhi.2016.2623421Yuehua Liu, Feilong Cao, Jianwei Zhao, Jianjun ChuSegmentation of white blood cells (WBCs) image is meaningful but challenging due to the complex internal characteristics of the cells and external factors, such as illumination and different microscopic views. This paper addresses two problems of the segmentation: WBC location and subimage segmentation. To locate WBCs, a method that uses multiple windows obtained by scoring multiscale cues to extract ...
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Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic EffectsChinese Medical Journal Pub Date : 2017-04-05 ,DOI:10.4103/0366-6999.202735Wen-Fang Tian, Ping Weng, Qiong Sheng, Jun-Liang Chen, Peng Zhang, Ji-Ru Zhang, Bin Du, Min-Chen Wu, Qing-Feng Pang, Jian-Jun Chu
Background: Biliverdin (BV) has a protective role against ischemia-reperfusion injury (IRI). However, the protective role and potential mechanisms of BV on lung IRI (LIRI) remain to be elucidated. Thus, we aimed to investigate the protective role and potential mechanisms of BV on LIRI. Methods: Lungs were isolated from Sprague-Dawley rats to establish an ex vivo LIRI model. After an initial 15 min
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Biliverdin Protects the Isolated Rat Lungs from Ischemia-reperfusion Injury via Antioxidative, Anti-inflammatory and Anti-apoptotic Effects.Chinese Medical Journal Pub Date : 2017-03-28 ,DOI:10.4103/0366-6999.202735Wen-Fang Tian,Ping Weng,Qiong Sheng,Jun-Liang Chen,Peng Zhang,Ji-Ru Zhang,Bin Du,Min-Chen Wu,Qing-Feng Pang,Jian-Jun Chu
BACKGROUND Biliverdin (BV) has a protective role against ischemia-reperfusion injury (IRI). However, the protective role and potential mechanisms of BV on lung IRI (LIRI) remain to be elucidated. Thus, we aimed to investigate the protective role and potential mechanisms of BV on LIRI. METHODS Lungs were isolated from Sprague-Dawley rats to establish an ex vivo LIRI model. After an initial 15 min stabilization
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Induction chemotherapy followed by concurrent chemoradiation and nimotuzumab for locoregionally advanced nasopharyngeal carcinoma: preliminary results from a phase II clinical trial.Oncotarget Pub Date : 2016-12-16 ,DOI:10.18632/oncotarget.13899Jian-Feng Huang,Fu-Zheng Zhang,Qin-Zhou Zou,Le-Yuan Zhou,Bo Yang,Jian-Jun Chu,Jia-Hua Yu,Hao-Wen Zhang,Xiao-Peng Yuan,Guo-Mei Tai,Fen-Ju Liu,C-M Charlie Ma
Overexpression of epidermal growth factor receptor can be found in more than 80% of patients with locoregionally advanced nasopharyngeal carcinoma and is associated with shorter survival. In this work, we evaluated the feasibility of adding nimotuzumab to chemoradiation in locoregionally advanced nasopharyngeal carcinoma. Twenty-three patients with clinically staged T3-4 or any node-positive disease
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Induction chemotherapy followed by concurrent chemoradiation and nimotuzumab for locoregionally advanced nasopharyngeal carcinoma: preliminary results from a phase II clinical trialOncotarget Pub Date : 2016-12-10 ,DOI:10.18632/oncotarget.13899Jian-feng Huang, Fu-zheng Zhang, Qin-zhou Zou, Le-yuan Zhou, Bo Yang, Jian-jun Chu, Jia-hua Yu, Hao-wen Zhang, Xiao-peng Yuan, Guo-mei Tai, Fen-ju Liu, C-M Charlie Ma
Overexpression of epidermal growth factor receptor can be found in more than 80% of patients with locoregionally advanced nasopharyngeal carcinoma and is associated with shorter survival. In this work, we evaluated the feasibility of adding nimotuzumab to chemoradiation in locoregionally advanced nasopharyngeal carcinoma. Twenty-three patients with clinically staged T3-4 or any node-positive disease
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Automatic detection and classification of leukocytes using convolutional neural networks.Medical & Biological Engineering & Computing (IF 3.079) Pub Date : 2016-11-09 ,DOI:10.1007/s11517-016-1590-xJianwei Zhao,Minshu Zhang,Zhenghua Zhou,Jianjun Chu,Feilong CaoThe detection and classification of white blood cells (WBCs, also known as Leukocytes) is a hot issue because of its important applications in disease diagnosis. Nowadays the morphological analysis of blood cells is operated manually by skilled operators, which results in some drawbacks such as slowness of the analysis, a non-standard accuracy, and the dependence on the operator's skills. Although ...
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Kinetic resolution of racemic styrene oxide at a high concentration by recombinant Aspergillus usamii epoxide hydrolase in an n-hexanol/buffer biphasic system.Journal of Biotechnology (IF 3.595) Pub Date : 2016-08-23 ,DOI:10.1016/j.jbiotec.2016.08.013Die Hu,Rui Wang,Xiao-Ling Shi,Hui-Hua Ye,Qin Wu,Min-Chen Wu,Jian-Jun ChuUsing the cell-free extract of engineered E. coli/Aueh2, expressing the recombinant Aspergillus usamii epoxide hydrolase (reAuEH2), as a biocatalyst, the kinetic resolution technique of racemic styrene oxide (rac-SO) was examined. In a phosphate buffer system (50mM, pH 7.0), 200mM rac-SO was efficiently resolved, obtaining (S)-SO with 98.1% enantiomeric excess (e.e.), whereas (S)-SO only with 45.2% ...
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A novel segmentation algorithm for nucleus in white blood cells based on low-rank representationNeural Computing and Applications (IF 5.102) Pub Date : 2016-06-01 ,DOI:10.1007/s00521-016-2391-8Feilong Cao,Miaomiao Cai,Jianjun Chu,Jianwei Zhao,Zhenghua ZhouWhite blood cells (WBCs) segmentation is a challenging problem in the study of automated morphological systems, due to both the complex nature of the cells and the uncertainty that is present in video microscopy. This paper investigates how to boost the effects of region-based nucleus segmentation in WBCs by means of optimal thresholding and low-rank representation. The main idea is firstly using optimal ...
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MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2.Cellular Physiology and Biochemistry Pub Date : 2015-10-23 ,DOI:10.1159/000438513Fei Zhang,Jing Wang,Jianjun Chu,Cheng Yang,Hui Xiao,Chenglong Zhao,Zhengwang Sun,Xin Gao,Guanghui Chen,Zhitao Han,Weiwei Zou,Tielong Liu
BACKGROUND/AIMS There have been many studies on the etiology of osteoarthritis (OA) with regard to the function of inflammatory cytokines, the process of cartilage degradation, the function of miR-146a, hypoxia stimulation and autophagy in OA chondrocytes, but there have been no reports on the relationship between miR-146a and autophagy in cartilage, especially under hypoxia. This study aimed to confirm
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In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion.Oncotarget Pub Date : 2015-06-20 ,DOI:10.18632/oncotarget.4416Xiaopan Cai,Jian Luo,Xinghai Yang,Huayun Deng,Jishen Zhang,Shichang Li,Haifeng Wei,Cheng Yang,Leqin Xu,Rongrong Jin,Zhenxi Li,Wang Zhou,JianDong Ding,Jianjun Chu,Lianshun Jia,Qi Jia,Chengjun Tan,Mingyao Liu,Jianru Xiao
We developed a murine spine metastasis model by screening five metastatic non-small cell lung cancer cell lines (PC-9, A549, NCI-H1299, NCI-H460, H2030). A549 cells displayed the highest tendency towards spine metastases. After three rounds of selection in vivo, we isolated a clone named A549L6, which induced spine metastasis in 80% of injected mice. The parameters of the A549L6 cell spinal metastatic
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IRX2-mediated upregulation of MMP-9 and VEGF in a PI3K/AKT-dependent manner.Molecular Medicine Reports (IF 3.423) Pub Date : 2015-06-13 ,DOI:10.3892/mmr.2015.3915Tielong Liu,Weiwei Zhou,Bing Cai,Jianjun Chu,Guodong Shi,Honglin Teng,Jian Xu,Jianru Xiao,Yan Wang
Osteosarcoma (OS) is the most frequent type of primitive malignant bone tumor with a poor prognosis due to distant metastasis. Our previous studies have demonstrated that IRX2 is overexpressed and is important in cell proliferation and invasion. However, the molecular mechanisms underlying the IRX2‑dependent regulation of OS progression remains to be elucidated. In the present study, the effects of
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Scientific publication in orthopedics journals from Chinese authors: a survey of 10-year survey of the literature.European Spine Journal (IF 2.721) Pub Date : 2015-06-10 ,DOI:10.1007/s00586-015-4024-9Jing Wang,Chenglong Zhao,Jianjun Chu,Cheng Yang,Jinhai Kong,Zhengwang Sun,Hui Xiao,Tielong Liu,Jianru XiaoThe Spinal Tumor Center, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, China,PURPOSE In the scientific community, a scientist's productivity is usually measured by his scientific output. The productivity of a group, an institution or, on a larger scale, a country can be assessed in similar manner. This study aims to show the contribution of Chinese authors to orthopedics research, from three major regions, namely Mainland China, Taiwan, and Hong Kong. METHODS Articles published ...
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In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesionOncotarget Pub Date : 2015-06-10 ,DOI:10.18632/oncotarget.4416Xiaopan Cai, Jian Luo, Xinghai Yang, Huayun Deng, Jishen Zhang, Shichang Li, Haifeng Wei, Cheng Yang, Leqin Xu, Rongrong Jin, Zhenxi Li, Wang Zhou, JianDong Ding, Jianjun Chu, Lianshun Jia, Qi Jia, Chengjun Tan, Mingyao Liu, Jianru Xiao
We developed a murine spine metastasis model by screening five metastatic non-small cell lung cancer cell lines (PC-9, A549, NCI-H1299, NCI-H460, H2030). A549 cells displayed the highest tendency towards spine metastases. After three rounds of selection in vivo, we isolated a clone named A549L6, which induced spine metastasis in 80% of injected mice. The parameters of the A549L6 cell spinal metastatic
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Caffeic acid phenethyl ester attenuates ionize radiation-induced intestinal injury through modulation of oxidative stress, apoptosis and p38MAPK in rats.Environmental Toxicology and Pharmacology (IF 5.785) Pub Date : 2015-05-31 ,DOI:10.1016/j.etap.2015.05.012Liu-Gen Jin,Jian-Jun Chu,Qing-Feng Pang,Fu-Zheng Zhang,Gang Wu,Le-Yuan Zhou,Xiao-Jun Zhang,Chun-Gen XingCaffeic acid phenyl ester (CAPE) is a potent anti-inflammatory agent and it can eliminate the free radicals. This study aimed to investigate the radioprotective effects of CAPE on X-ray irradiation induced intestinal injury in rats. Rats were intragastrically administered with 10 μmol/kg/d CAPE for 7 consecutive days before exposing them to a single dose of X-ray irradiation (9 Gy) to abdomen. Rats ...
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Protective effects of caffeic acid phenethyl ester against acute radiation-induced hepatic injury in rats.Environmental Toxicology and Pharmacology (IF 5.785) Pub Date : 2015-02-07 ,DOI:10.1016/j.etap.2015.01.020JianJun Chu,Xiaojun Zhang,Liugen Jin,Junliang Chen,Bin Du,Qingfeng PangCaffeic acid phenyl ester (CAPE) is a potent anti-inflammatory agent and it can eliminate the free radicals. The current study was intended to evaluate the protective effect of CAPE against the acute radiation-induced liver damage in rats. Male Sprague–Dawley rats were intraperitoneally administered with CAPE (30 mg/kg) for 3 consecutive days before exposing them to a single dose of 30 Gy of β-ray ...
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MicroRNA-146a Induced by Hypoxia Promotes Chondrocyte Autophagy through Bcl-2Cellular Physiology and Biochemistry Pub Date : 2015-01-01 ,DOI:10.1159/000438513Fei Zhang, Jing Wang, Jianjun Chu, Cheng Yang, Hui Xiao, Chenglong Zhao, Zhengwang Sun, Xin Gao, Guanghui Chen, Zhitao Han, Weiwei Zou, Tielong Liu
Background/Aims: There have been many studies on the etiology of osteoarthritis (OA) with regard to the function of inflammatory cytokines, the process of cartilage degradation, the function of miR-146a, hypoxia stimulation and autophagy in OA chondrocytes, but there have been no reports on the relationship between miR-146a and autophagy in cartilage, especially under hypoxia. This study aimed to confirm
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Surgical treatment for idiopathic intervertebral disc calcification in a child: case report and review of the literature.Child's Nervous System (IF 1.532) Pub Date : 2014-09-06 ,DOI:10.1007/s00381-014-2539-8Jianjun Chu,Tao Wang,Shaobao Pei,Zongsheng YinDepartment of Spine Surgery, Hefei Binhu Hospital, The Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China.PURPOSE Intervertebral disc calcification (IDC) is rare in children. Conservative treatment has been recommended for the majority of cases. We describe surgical treatment of a case of IDC with progressive neurological impairment and review the literature relevant to this rare entity and its management. METHODS A 16-year-old boy presented with sudden onset of severe neck pain, radiating into his left ...
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High efficacy of gefitinib in the treatment of EGFR mutation-positive advanced non-small cell lung adenocarcinoma: A case report.Oncology Letters (IF 3.111) Pub Date : 2014-06-19 ,DOI:10.3892/ol.2014.2269Zhongchao Wang,Jianjun Chu
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, are known to play a significant role in EGFR mutation-positive non-small cell lung cancer. When an EGFR mutation is found, gefitinib and erlotinib have been shown to have significant roles in the treatment of untreated advanced NSCLC. This study reports an EGFR mutation in NSCLC treated with
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