- 作 者: ( "xinyu shen" OR "xin-yu shen" )
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Coixol ameliorates Toxoplasma gondii infection-induced lung injury by interfering with T. gondii HSP70/TLR4/NF-κB signaling pathwayInternational Immunopharmacology (IF 5.714) Pub Date : 2023-03-16 ,DOI:10.1016/j.intimp.2023.110031Xin-Yu Shen, Jing-Mei Lu, Yu-Nan Lu, Guang-Nan Jin, Jing-Wen Ma, Jing-He Wang, Yu Wang, Xiang Xu, Lian-Xun PiaoToxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that causes pulmonary toxoplasmosis, although its pathogenesis is incompletely understood. There is no cure for toxoplasmosis. Coixol, a plant polyphenol extracted from coix seeds, has a variety of biological activities. However, the effects of coixol on T. gondii infection have not been clarified. In this study, we infected ...
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Allantoin induces pruritus by activating MrgprD in chronic kidney diseaseJournal of Cellular Physiology (IF 6.513) Pub Date : 2023-03-06 ,DOI:10.1002/jcp.30977Yan Yang, Yulin Sun, Chan Zhu, Xinyu Shen, Jianmei Sun, Tao Jing, Shi Jun, Changming Wang, Guang Yu, Xinzhong Dong, Meixiao Sheng, Zongxiang Tang
Chronic kidney disease (CKD) is a disease with decreased, irreversible renal function. Pruritus is the most common skin symptom in patients with CKD, especially in end-stage renal disease. The underlying molecular and neural mechanism of CKD-associated pruritus (CKD-aP) remains obscure. Our data show that the level of allantoin increases in the serum of CKD-aP and CKD model mice. Allantoin could induce
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Passivation strategies for mitigating defect challenges in halide perovskite light-emitting diodesJoule (IF 46.048) Pub Date : 2023-02-15 ,DOI:10.1016/j.joule.2023.01.008Xinyu Shen, Keehoon Kang, Zhongkai Yu, Woo Hyeon Jeong, Hyosung Choi, Sung Heum Park, Samuel D. Stranks, Henry J. Snaith, Richard H. Friend, Bo Ram LeeDespite the well-established defect tolerance of metal halide perovskites (MHPs), there are multiple sources of defects in MHPs, such as grain boundaries in thin films, colloidal nanocrystal surfaces, and a heterointerface formed with the charge-transport layer, all of which play a crucial role in determining the efficiency and stability of light-emitting diodes (LEDs). Defect passivation strategies ...
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Wide-coverage and Efficient NIR Emission from Single-component Nanophosphors through Shaping Multiple Metal-halide PackagesAngewandte Chemie International Edition (IF 16.823) Pub Date : 2023-02-09 ,DOI:10.1002/anie.202217832Xin Li, Xinyu Shen, Min Lu, Jinlei Wu, Yuan Zhong, Zhennan Wu, William W. Yu, Yanbo Gao, Junhua Hu, Jinyang Zhu, Yu Zhang, Xue BaiThe widest-coverage single-component near-infrared (NIR) emission (850–1650 nm) with the high NIR photoluminescence quantum yield (PLQY) of 20.3 % in Sm3+, Nd3+, Er3+ triple-doped Cs2K0.5Rb0.5(In0.95Sb0.05)Cl6 NCs is achieved. The remarkable results are attributed to the improved energy transfer efficiency between host and lanthanide (Ln3+) ions and reduced cation site symmetry of Ln3+ ions due to ...
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Bimodal accuracy distribution of link prediction in complex networksInternational Journal of Modern Physics C (IF 1.353) Pub Date : 2023-01-20 ,DOI:10.1142/s0129183123500985Chengjun Zhang, Ming Qian, Xinyu Shen, Qi Li, Yi Lei, Wenbin YuLink prediction plays an important role in information filtering and numerous research works have been made in this field. However, traditional link prediction algorithms mainly focus on overall prediction accuracy, ignoring the heterogeneity of the prediction accuracy for different links. In this paper, we analyzed the prediction accuracy of each link in networks and found that the prediction accuracy ...
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Fragility Induced by Interdependency of Complex Networks and Their Higher-Order Networks.Entropy (IF 2.738) Pub Date : 2022-12-23 ,DOI:10.3390/e25010022Chengjun Zhang,Yi Lei,Xinyu Shen,Qi Li,Hui Yao,Di Cheng,Yifan Xie,Wenbin Yu
The higher-order structure of networks is a hot research topic in complex networks. It has received much attention because it is closely related to the functionality of networks, such as network transportation and propagation. For instance, recent studies have revealed that studying higher-order networks can explore hub structures in transportation networks and information dissemination units in neuronal
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Near-Infrared LEDs Based on Quantum Cutting-Activated Electroluminescence of Ytterbium IonsNano Letters (IF 12.262) Pub Date : 2022-12-21 ,DOI:10.1021/acs.nanolett.2c03679Xinyu Shen, Zhenyu Wang, Chengyuan Tang, Xiangtong Zhang, Bo Ram Lee, Xin Li, Daguang Li, Yu Zhang, Junhua Hu, Dan Zhao, Fujun Zhang, William W. Yu, Bin Dong, Xue BaiCesium lead halide perovskite nanocrystals (PNCs) exhibit promising prospects for application in optoelectronic devices. However, electroactivated near-infrared (NIR) PNC light-emitting diodes (LEDs) with emission peaks over 800 nm have not been achieved. Herein, we demonstrate the electroactivated NIR PNC LEDs based on Yb3+-doped CsPb(Cl1–xBrx)3 PNCs with extraordinary high NIR photoluminescence quantum ...
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Rutin ameliorates inflammatory pain by inhibiting P2X7 receptor in mast cellsJournal of Physiology and Biochemistry (IF 5.08) Pub Date : 2022-12-13 ,DOI:10.1007/s13105-022-00938-wFan Ye, Jiahua Lv, Xinyu Shen, Jian Zhang, Yingxin Zong, Chan Zhu, Yan Yang, Keke Jia, Yucui Jiang, Zongxiang TangRutin is a natural anti-inflammatory ingredient widely found in medicinal plants. Studies have shown that rutin inhibits mast cell degranulation and the release of inflammatory mediators. Mast cell P2X7 receptor mediates mast cell degranulation and serves as a therapeutic target for inflammatory pain. Herein, the aim of this study was to investigate whether the anti-inflammatory mechanism of rutin ...
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Immunotherapy-Associated Hypophysitis Under Anti-PD1: Two Case ReportsEndocrine, Metabolic & Immune Disorders - Drug Targets (IF 2.387) Pub Date : 2022-12-12 ,DOI:10.2174/1871530323666221208111823Xinyu Shen, Minglan Yang, Jing Ma, Hua Xu, Huan Zhou, Liwei WangBackground: Immunotherapy-associated hypophysitis is an uncommon adverse event. However, if not handled properly, it could lead to fatal sequelae. Case description: Case 1. A 66-year-old man presented to our hospital with hyponatremia. He had low plasma levels of adrenocorticotropin and cortisol. The patient had a history of non-small cell lung cancer and had undergone 16 cycles of immunotherapy with ...
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Immunotherapy-Associated Hypophysitis Under Anti-PD1: Two Case Reports.Endocrine, metabolic & immune disorders drug targets Pub Date : 2022-12-08 ,DOI:10.2174/1871530323666221208111823Xinyu Shen,Minglan Yang,Hua Xu,Huan Zhou,Liwei Wang,Jing MaBackground Immunotherapy-associated hypophysitis is an uncommon adverse event. However, if not handled properly, it could lead to fatal sequelae. Case description Case 1. A 66-year-old man presented to our hospital with hyponatremia. He had low plasma levels of adrenocorticotropin and cortisol. The patient had a history of non-small cell lung cancer and had undergone 16 cycles of immunotherapy with ...
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Plasmon-Enhanced Ultrasensitive Digital Imaging Immunoassay for the Quantification of microRNAs Assisted by Convolutional Neural Network AnalysisAdvanced Functional Materials (IF 19.924) Pub Date : 2022-11-28 ,DOI:10.1002/adfm.202210561Zhongwen Long, Xinyu Shen, Xiaobo Zhang, Hui Zhang, Qianwei Zhou, Cheng Yang, Yuzhang Liang, Ting XuDigital imaging immunoassays for precisely detecting microRNAs have attracted much attention in early cancer diagnosis. Currently, there is an urgent demand for improving the sensitivity and selectivity in digital immunoassays, which is limited by low imaging signal-to-noise ratio and pollutant interference. Herein, a plasmon-enhanced ultrasensitive and selective digital-readout imaging immunoassay ...
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Effect of oxides composition on the mechanical properties of non-sintered spherical filters from waste steel slagEnvironmental Progress & Sustainable Energy (IF 2.824) Pub Date : 2022-11-14 ,DOI:10.1002/ep.14044Xiaoya Yan, Xinyu Shen, Yang Lin, Yueqing Xu, Yan Han, Rong LiuNon-sintered spherical filters (NSSFs) from the waste steel slag for bottom filtration process are regarded as promising materials for sustainable development with economical benefits due to saving natural resource pebbles. To further optimize the preparation process, the influence mechanism of the main oxides on characteristics are comprehensively examined in this work. CaO in the raw materials makes ...
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Preparation of millimeter-scale hard layer on the surface of titanium alloy via self-propagating high temperature synthesis combined with hot pressing sintering processJournal of Materials Research and Technology (IF 6.267) Pub Date : 2022-11-07 ,DOI:10.1016/j.jmrt.2022.10.166Xinyu Shen, Tiejian Su, Qunbo Fan, Shun Xu, Lin Yang, Haichao Gong, Qianyun Yan, Cheng Cai
A hard and thick surface strengthening layer with high interfacial bonding strength was innovatively prepared via self-propagating high temperature synthesis (SHS) combined with hot pressing sintering (HPS) process. The thickness of the surface layer reached 1.1 mm, far exceeding the strengthening layer prepared by the traditional surface modification methods of titanium alloy. The raw materials of
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Resveratrol inhibits Toxoplasma gondii-induced lung injury, inflammatory cascade and evidences of its mechanism of actionPhytomedicine (IF 6.656) Pub Date : 2022-10-22 ,DOI:10.1016/j.phymed.2022.154522Yu Nan Lu, Xin Yu Shen, Jing Mei Lu, Guang Nan Jin, Hui Wen Lan, Xiang Xu, Lian Xun PiaoBackground Toxoplasma gondii is an opportunistic protozoan that can infect host to cause toxoplasmosis. We have previously reported that resveratrol (RSV) has protective effects against liver damage in T. gondii infected mice. However, the effect of RSV on lung injury caused by T. gondii infection and its mechanism of action remain unclear. Purpose In this work, we studied the protective effects of ...
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Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathwayInternational Immunopharmacology (IF 5.714) Pub Date : 2022-09-26 ,DOI:10.1016/j.intimp.2022.109257Yuehong Shen, Xinyu Shen, Shulin Wang, Yunyun Zhang, Yue Wang, Ye Ding, Jiayun Shen, Jianqiao Zhao, Huahan Qin, Yijiao Xu, Qian Zhou, Xindong Wang, Jianping ShenAccumulating evidence has highlighted the role of ferroptosis, a novel type of programmed cell death involved in the pathological process of myocardial infarction (MI). However, the underlying mechanism of ferroptosis in mediating MI is complicated that needs to be further investigated. Salvianolic acid B (Sal B) extracted from the traditional Chinese medicine (TCM) herb Salvia miltiorrhiza possesses ...
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Protective effect of ginsenoside Rh2 against Toxoplasma gondii infection-induced neuronal injury through binding TgCDPK1 and NLRP3 to inhibit microglial NLRP3 inflammasome signaling pathwayInternational Immunopharmacology (IF 5.714) Pub Date : 2022-09-05 ,DOI:10.1016/j.intimp.2022.109176Guang-Nan Jin, Jing-Mei Lu, Hui-Wen Lan, Yu-Nan Lu, Xin-Yu Shen, Xiang Xu, Lian-Xun PiaoBackground Toxoplasma gondii (T. gondii) is a neurotropic obligate intracellular parasite that can activate microglial and promote neuronal apoptosis, leading to central nervous system diseases. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome signaling complex plays a key role in inducing neuroinflammation. Our previous studies have found that ginsenoside Rh2 (GRh2) inhibits ...
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Flexural performance of RC beams strengthened with inorganic adhesive bonded NSM CFRP barStructures (IF 4.01) Pub Date : 2022-08-22 ,DOI:10.1016/j.istruc.2022.08.041Jin-Guang Yu, Liang Cheng, Xinyu Shen, Yunfeng Hu, Bo LiOrganic adhesives (e.g. epoxy) have been widely utilized in near-surface mounted (NSM) carbon fibre reinforced polymer (CFRP) strengthening technique for reinforced concrete (RC) structural members. Their inevitable shortcomings, such as poor fire resistance, emission of toxic fumes, and incompatibility with concrete substrate, necessitate the advancement of eco-friendly inorganic adhesives. In this ...
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Influential mechanisms on interface bonding of hot-rolled TB9/TC4 laminated compositesMaterials Science and Engineering: A (IF 6.044) Pub Date : 2022-08-09 ,DOI:10.1016/j.msea.2022.143749Qianyun Yan, Qunbo Fan, Suyuan Yang, Lin Yang, Duoduo Wang, Haichao Gong, Shun Xu, Jingjiu Yuan, Xinyu Shen, Naitao GengTo promote the application of laminated composites with high strength and plasticity in armor field, the feature of interface bonding and the influential mechanisms accounting for the interface quality need clarification. In this work, laminated composites of high-strength TB9 and good-toughness TC4 were successfully manufactured by high temperature rolling with different thickness reduction. Microstructural ...
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A polymer/small-molecule binary-blend hole transport layer for enhancing charge balance in blue perovskite light emitting diodesJournal of Materials Chemistry A (IF 14.511) Pub Date : 2022-06-08 ,DOI:10.1039/d2ta01987fZhongkai Yu, Woo Hyeon Jeong, Keehoon Kang, Hochan Song, Xinyu Shen, Hyungju Ahn, Seok Woo Lee, Xiangyang Fan, Ji Won Jang, Su Ryong Ha, Jeong Wan Min, Jong Hyun Park, Jongmin Han, Eui Dae Jung, Myoung Hoon Song, Dong Wook Chang, Won Bin Im, Sung Heum Park, Hyosung Choi, Bo Ram LeeMetal halide based perovskite light-emitting diodes (PeLEDs) are promising candidates for next generation commercial display products due to their excellent high color-purity and recent dramatic improvements in their device efficiencies. However, the performance of blue PeLEDs falls far short of the requirements of commercialization, for which one of the main reasons is the wide band gap of blue-emitting ...
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Numerical study on flexural behaviour of FRP reinforced concrete beams with compression yielding blocksCase Studies in Construction Materials Pub Date : 2022-05-20 ,DOI:10.1016/j.cscm.2022.e01169Xinyu Shen, Bo Li, Weizhuo Shi, Yung-Tsang Chen
Fibre-reinforced polymer (FRP) bars are used in concrete structural members to tackle the corrosion problem of steel bars. However, the brittle rupture of FRP bars results in relatively low ductility of such concrete members. This paper numerically investigates the feasibility of using compression yielding (CY) block to enhance the ductility of FRP bar reinforced concrete beams. A finite element model
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Geniposide Possesses the Protective Effect on Myocardial Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Grsf1/GPx4 AxisFrontiers in Pharmacology (IF 5.988) Pub Date : 2022-05-05 ,DOI:10.3389/fphar.2022.879870Yuehong Shen, Xindong Wang, Xinyu Shen, Yue Wang, Shulin Wang, Yunyun Zhang, Xiaoming Yao, Yijiao Xu, Ming Sang, Jiamin Pan, Yu Qin, Qian Zhou, Jianping Shen
Reactive oxygen species (ROS) produced in the ischemic myocardium can induce cardiomyocyte injury and death, resulting in cardiac remodeling. Ferroptosis, known as a newly type of cell death caused by iron-dependent oxidative stress, which is an essential death mechanism in cardiomyocytes. However, it is unclear whether oxidative stress products can further induce ferroptosis and aggravate cardiomyocyte
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Comprehensive Analysis of the Surface Decoration Layer of Buddha Statues from Dazu Rock Carvings in ChinaAnalytical Letters (IF 2.267) Pub Date : 2022-03-02 ,DOI:10.1080/00032719.2022.2043889Quan Chen, Feng Gao, Xin Wang, Xinying Hao, Hua Tong, Liya Ma, Xinyu ShenAbstract The surface decoration layers of Samantabhadra Bodhisattva and Thousand Hand Guanyin from Dazu Rock Carvings were examined using digital microscopy, energy-dispersive spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and pyrolysis—gas chromatography/mass spectrometry using thermally assisted hydrolysis and methylation. Gypsum was present in the preparation layer, while ...
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Reduced-Dimensional Engineering toward 2D R-P (OAm)2CsPb2Br7 Perovskite by Metal Ion Enabled Ligands Confinement EffectAdvanced Materials Interfaces (IF 6.389) Pub Date : 2022-03-02 ,DOI:10.1002/admi.202102251Xupeng Gao, Qiang Hu, Xin Li, Po Lu, Yuan Zhong, Xinyu Shen, William W. Yu, Min Lu, Zhennan Wu, Siyao Yu, Xue Bai, Yu ZhangThe dimension is a leading parameter in customization of unique optoelectronic properties of halide perovskite, while it is still challenging to achieve dimension control beyond the well-developed composition regulation-based strategy considering their intrinsic feature of ionic crystal. In this paper, ligands-directed confinement effect is emphasized in rendering the reduced-dimensional engineering ...
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Potassium chloride-catalyzed growth of porous carbon nanotubes for high-performance supercapacitorsJournal of Alloys and Compounds (IF 6.371) Pub Date : 2022-02-17 ,DOI:10.1016/j.jallcom.2022.164242Song Lv, Liya Ma, Xinyu Shen, Hua TongPorous carbon nanotubes with unique structure is an ideal electrode material for supercapacitors. However, the synthesis of porous carbon nanotubes requires expensive catalysts such as heavy metals or heavy metal salts, which limits their wider application. To solve the problem, a one-step high-temperature potassium chloride-catalyzed strategy is proposed to directly grow porous carbon nanotubes. Magnesium ...
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Metabolomics-based comparative study of breast colostrum and mature breast milkFood Chemistry (IF 9.231) Pub Date : 2022-02-16 ,DOI:10.1016/j.foodchem.2022.132491Mohan Li, Jiali Chen, Xinyu Shen, Rayhnigul Abdlla, Lifei Liu, Xiqing Yue, Qilong LiBreast milk is the safest and most complete natural food for babies. Although breast milk is crucial to the health and development of infants, the metabolites in breast milk during lactation period have not been characterized. Therefore, we examined and compared the metabolites in breast colostrum and mature breast milk using gas chromatography-time-of-flight-mass spectrometry-based metabolomics. A ...
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Efficient and Stable CF3PEAI-Passivated CsPbI3 QDs toward Red LEDsACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2022-02-04 ,DOI:10.1021/acsami.1c19685Zhenyu Wang, Xinyu Shen, Chengyuan Tang, Xin Li, Junhua Hu, Jinyang Zhu, William W. Yu, Hongwei Song, Xue BaiOleylamine and oleic acid are common organic capping ligands used in the hot injection preparation of perovskite quantum dots (QDs). Their labile nature is responsible for the poor colloidal stability and conductivity that affect the performance of perovskite QD light-emitting diodes (LEDs). We introduced 4-trifluoro phenethylammonium iodide (CF3PEAI) directly in the synthesis and found that CF3PEAI ...
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Experimental and numerical study on reinforced concrete beam-column joints with diagonal bars: Effects of bonding condition and diameterStructures (IF 4.01) Pub Date : 2022-02-01 ,DOI:10.1016/j.istruc.2022.01.050Xinyu Shen, Bo Li, Yung-Tsang Chen, Walid TizaniDiagonal bars anchored in beams have been proven to be an effective reinforcement detail for reinforced concrete interior beam-column joints (BCJs) in mitigating the congestion of conventional stirrups without compromising their seismic performance. This paper investigates the effects of bonding condition and diameter of diagonal bars on the seismic performance of interior BCJs. Four interior BCJ specimens ...
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Nitrogen and sulfur co-doped porous chitosan hydrogel-derived carbons for supercapacitorsJournal of Electroanalytical Chemistry (IF 4.598) Pub Date : 2022-01-19 ,DOI:10.1016/j.jelechem.2022.116060Song Lv, Liya Ma, Xinyu Shen, Hua TongTo achieve high-performance supercapacitors, nitrogen and sulfur co-doped porous chitosan hydrogel-derived carbons (CHC-SK) are successfully prepared by one-step carbonization. In the synthesis, two effective strategies of structure design and heteroatom doping are both used to increase capacitance of carbon materials. To control and design of structure, potassium citrate as a novel pore-former is ...
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Characterization and comparison of whey proteomes from bovine and donkey colostrum and mature milkLWT - Food Science and Technology (IF 6.056) Pub Date : 2022-01-18 ,DOI:10.1016/j.lwt.2022.113113Mohan Li, Yushi Dong, Weixuan Li, Xinyu Shen, Rayhnigul Abdlla, Jiali Chen, Xueyan Cao, Xiqing Yue
As a small species of milk source, donkey milk has attracted widespread attention due to its high nutritional value. However, its composition is substantially different from the most widely consumed milk source—bovine milk. This study was aimed to conduct a qualitative proteomic analysis of donkey whey proteins (DWPs) and bovine whey proteins (BWPs). Specifically, 981, 988, 1127, and 1534 whey proteins
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Enhancing the Efficiency and Stability of CsPbI3 Nanocrystal-Based Light-Emitting Diodes through Ligand Engineering with OctylamineThe Journal of Physical Chemistry C (IF 4.177) Pub Date : 2022-01-07 ,DOI:10.1021/acs.jpcc.1c10115Hanming Li, Wei Dong, Xinyu Shen, Chengda Ge, Yilong Song, Zisheng Wang, Anran Wang, Ziqi Yang, Mingwei Hao, Yu Zhang, Weitao Zheng, Xiaoyu Zhang, Qingfeng DongBright perovskite nanocrystals with high color purity are promising for high-definition displays; however, their complex postprocessing process limits their large-scale production. Using a trace of octylamine to regulate the dynamic balance between surface ligand adsorption and desorption, we develop a facile method to obtain stable CsPbI3 nanocrystal films that combine excellent optical and electrical ...
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