- 作 者: "ying ao"
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Prenatal exposure to corn oil, CMC-Na or DMSO affects physical development and multi-organ functions in fetal miceReproductive Toxicology (IF 3.421) Pub Date : 2023-03-22 ,DOI:10.1016/j.reprotox.2023.108366Kaiqi Chen, Xiaoqian Lu, Dan Xu, Yu Guo, Ying Ao, Hui WangCorn oil, sodium carboxymethyl cellulose (CMC-Na), and dimethyl sulfoxide (DMSO) are widely used as solvents or suspensions in animal experiments, but the effects of prenatal exposure to them on fetal development have not been reported. In this study, Kunming mice were given a conventional dose of corn oil (9.2 g/kg·d), CMC-Na (0.05 g/kg·d) or DMSO (0.088 g/kg·d) during gestation days 10-18, and the ...
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DAPL1 deficiency in mice impairs antioxidant defenses in the RPE and leads to retinal degeneration with AMD-like featuresRedox Biology (IF 10.787) Pub Date : 2023-03-15 ,DOI:10.1016/j.redox.2023.102675Xiaoyin Ma, Huaicheng Chen, Shuhui Jian, Junhao He, Youjia Liu, Shuxian Han, Lifu Chang, Pingping Li, Ying-ao Chen, Xiaoyan Liu, Xiaojuan Hu, Yu Chen, Ling HouThe decreased antioxidant capacity in the retinal pigment epithelium (RPE) is the hallmark of retinal degenerative diseases including age-related macular degeneration (AMD). Nevertheless, the exact regulatory mechanisms underlying the pathogenesis of retinal degenerations remain largely unknown. Here we show in mice that deficiencies in Dapl1, a susceptibility gene for human AMD, impair the antioxidant ...
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SIRT1 Inhibits High Glucose–Induced TXNIP/NLRP3 Inflammasome Activation and Cataract FormationInvestigative Ophthalmology & Visual Science (IF 4.925) Pub Date : 2023-03-01 ,DOI:10.1167/iovs.64.3.16Lili Lian, Zhenmin Le, Zhenzhen Wang, Ying-ao Chen, Xiaodong Jiao, Hang Qi, J. Fielding Hejtmancik, Xiaoyin Ma, Qinxiang Zheng, Yueping Ren
Purpose: To determine whether SIRT1 regulates high glucose (HG)–induced inflammation and cataract formation through modulating TXNIP/NLRP3 inflammasome activation in human lens epithelial cells (HLECs) and rat lenses. Methods: HG stress from 25 to 150 mM was imposed on HLECs, with treatments using small interfering RNAs (siRNAs) targeting NLRP3, TXNIP, and SIRT1, as well as a lentiviral vector (LV)
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DAPL1 prevents epithelial–mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathyCell Death & Disease (IF 9.685) Pub Date : 2023-02-25 ,DOI:10.1038/s41419-023-05693-4Xiaoyin Ma, Shuxian Han, Youjia Liu, Yu Chen, Pingping Li, Xiaoyan Liu, Lifu Chang, Ying-ao Chen, Feng Chen, Qiang Hou, Ling Hou
Epithelial–mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is a hallmark of the pathogenesis of proliferative vitreoretinopathy (PVR) that can lead to severe vision loss. Nevertheless, the precise regulatory mechanisms underlying the pathogenesis of PVR remain largely unknown. Here, we show that the expression of death-associated protein-like 1 (DAPL1) is downregulated in PVR membranes
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Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence.Cells (IF 7.666) Pub Date : 2023-02-16 ,DOI:10.3390/cells12040639Ying Ao,Zhuping Wu,Zhiwei Liao,Juncong Lan,Jie Zhang,Pengfei Sun,Baohua Liu,Zimei Wang
The nuclear matrix protein lamin A is a multifunctional protein with roles in DNA replication and repair, gene activation, transcriptional regulation, and maintenance of higher-order chromatin structure. Phosphorylation is the main determinant of lamin A mobility in the nucleus and nuclear membrane dissolution during mitosis. However, little is known about the regulation of lamin A phosphorylation
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Antagonistic Activity and Mechanism of Bacillus subtilis XZ16-1 Suppression of Wheat Powdery Mildew and Growth Promotion of WheatPhytopathology (IF 4.01) Pub Date : 2022-11-17 ,DOI:10.1094/phyto-04-22-0118-rYan-Jie Yi, Ya-Nan Yin, Ying-Ao Yang, Yu-Qian Liang, You-Tian Shan, Chang-Fu Zhang, Yu-Rong Zhang, Zhen-Pu LiangWheat powdery mildew caused by Blumeria graminis f. sp. tritici (Bgt) is one of the most serious wheat diseases in the world. Biological control is considered an environmentally safe approach to control plant diseases. Here, to develop effective biocontrol agents for controlling wheat powdery mildew, antagonistic strain XZ16-1 was isolated and identified as Bacillus subtilis based on the morphological ...
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Dysregulation of AMPK-mTOR signaling leads to comorbid anxiety in Dip2a KO mice.Cerebral Cortex (IF 4.861) Pub Date : 2022-10-13 ,DOI:10.1093/cercor/bhac393Jun Ma,Kai Li,Xue Sun,Jia-Nan Liang,Xian-Quan An,Meng Tian,Jing Li,Fang Yan,Yue Yin,Ying-Ao Yang,Fei-Yang Chen,Lu-Qing Zhang,Xiao-Xiao He,Zi-Xuan He,Wei-Xiang Guo,Xiao-Juan Zhu,Hua-Li YuAutism is often comorbid with other psychiatric disorders. We have previously shown that Dip2a knockout (KO) induces autism-like behaviors in mice. However, the role of Dip2a in other psychiatric disorders remains unclear. In this paper, we revealed that Dip2a KO mice had comorbid anxiety. Dip2a KO led to a reduction in the dendritic length of cortical and hippocampal excitatory neurons. Molecular ...
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Prenatal smoke (Nicotine) exposure and offspring's metabolic disease susceptibility in adulthoodFood and Chemical Toxicology (IF 5.572) Pub Date : 2022-08-27 ,DOI:10.1016/j.fct.2022.113384Bo He, Qi Zhang, Yu Guo, Ying Ao, Kai Tie, Hao Xiao, Liaobin Chen, Dan Xu, Hui WangExposure to smoking (nicotine) during pregnancy not only directly affects fetal development, but also increases susceptibility to metabolic diseases in adulthood, but the mechanism of action remains unclear. Here, we review epidemiological and laboratory studies linking these relationships. In addition to the direct effect of nicotine on the fetus, intrauterine neuroendocrine-metabolic programming ...
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One-pot synthesis of a cellulose-supported CoFe2O4 catalyst for the efficient degradation of sulfamethoxazoleInternational Journal of Biological Macromolecules (IF 8.025) Pub Date : 2022-08-03 ,DOI:10.1016/j.ijbiomac.2022.08.003Jing-jing Shao, Bo Cai, Cheng-rui Zhang, Ying-ao Hu, Hui PanCellulose-supported cobalt ferrite (CoFe2O4/RC) was synthesized via a facile one-pot hydrothermal method and demonstrated to be an efficient catalyst to activate peroxymonosulfate (PMS) for the degradation of sulfamethoxazole (SMX). The characterizations of CoFe2O4/RC catalysts revealed that an appropriate particle size of the cellulose support could promote the dispersion of CoFe2O4 nanoparticles ...
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Point-of-care non-invasive enzyme-cleavable nanosensors for acute transplant rejection detectionBiosensors and Bioelectronics (IF 12.545) Pub Date : 2022-07-13 ,DOI:10.1016/j.bios.2022.114568Shi-Jie Liu, Ke Ma, Long-Shan Liu, Ke Wang, Ying-Ao Zhang, Zi-Rong Bi, Yan-Xu Chen, Ke-Zheng Chen, Chang-Xi Wang, Sheng-Lin QiaoAccurate and non-invasive monitoring of allograft posttransplant is essential for early detection of acute cellular rejection and determines the long-term survival of the graft. Clinically, tissue biopsy is the most effective approach for diagnosing transplant rejection. Nonetheless, the procedure is invasive and potentially triggers organ failure. This work aims to design and apply GzmB-responsive ...
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Prenatal caffeine exposure induced renal developmental toxicity and transgenerational effect in rat offspringFood and Chemical Toxicology (IF 5.572) Pub Date : 2022-05-11 ,DOI:10.1016/j.fct.2022.113082Xiaoqi Zhao, Bin Li, Ying Xiong, Zhiping Xia, Shuangshuang Hu, Zhaoxia Sun, Hui Wang, Ying AoEpidemiological studies revealed that prenatal caffeine exposure (PCE) is associated with adverse gestational outcomes and susceptibility to chronic diseases in offspring, yet the effects of PCE on glomerulosclerosis susceptibility in adult female offspring and its intergenerational transmission remain to be further investigated. Here, we found that PCE caused fetal kidney dysplasia and glomerulosclerosis ...
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Charge-induced proton penetration across two-dimensional clay materialsNanoscale (IF 8.307) Pub Date : 2022-04-01 ,DOI:10.1039/d2nr00262kLe Shi, Yushuan Gao, Zhixuan Ying, Ao Xu, Yonghong ChengTwo-dimensional clay materials possess superior thermal and chemical stability, and the intrinsic tubular channels in their atomic structure provide possible routes for proton penetration. Therefore, they are expected to overcome the lack of materials that can conduct protons between 100–500 °C. In this work, we investigated the detailed proton penetration mechanism across 2D clay nanosheets with different ...
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Low H3K27 acetylation of SF1 in PBMC: a biomarker for prenatal dexamethasone exposure-caused adrenal insufficiency of steroid synthesis in male offspringCell Biology and Toxicology (IF 6.819) Pub Date : 2022-03-04 ,DOI:10.1007/s10565-021-09691-0Guanghui Chen, Can Ai, Fangfang Duan, Yawen Chen, Jiangang Cao, Jinzhi Zhang, Ying Ao, Hui WangDexamethasone is widely used to treat pregnancy disorders related to premature delivery. However, lots of researches have confirmed that prenatal dexamethasone exposure (PDE) could increase the risk of offspring multiple diseases. This study was designed to elucidate the epigenetic mechanism of adrenal developmental programming and explore its early warning marker in peripheral blood mononuclear cells ...
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Prenatal Exposure of Rats to Staphylococcal Enterotoxin B Alters the Expression of Th1 and Th2 Cytokines via Decreased Methylation in the Spleen of Adult but not Neonatal Offspring.Iranian journal of immunology : IJI Pub Date : 2022-03-01 ,DOI:10.22034/iji.2022.89946.1979Jing Sun,Jia-Bao Zhao,Chao Sun,Yu-Ting Zhu,Ping Zhou,Shu-Xian Gao,Ying-Ao Fan,Hao-Yuan Jiang,Qing-Wei Zheng,Jun-Chang GuanBACKGROUND The methylation of IFN-γ and IL-4 genes is regarded as an epigenetic regulation that maintains the Th1 or Th2 phenotype. OBJECTIVE To explore the influence of prenatal administration of the staphylococcal enterotoxin B (SEB) in pregnant rats, on the IFN-γ or IL-4 expression in the offspring spleen. METHODS The SEB or PBS was administered intravenously to pregnant rats on the embryo-day 16 ...
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Characterization of the Inclusion Complexes of Isothiocyanates with γ-Cyclodextrin for Improvement of Antibacterial Activities against Staphylococcus aureusFoods (IF 5.561) Pub Date : 2021-12-27 ,DOI:10.3390/foods11010060Jia-Nan Liu, Hong-Yan Wu, Xin-Ying Ao, Hong-Shun Hao, Jing-Ran Bi, Hong-Man Hou, Gong-Liang ZhangThe aim of this study was to develop inclusions formed by γ-cyclodextrin (γ-CD) and three isothiocyanates (ITCs), including benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and 3-methylthiopropyl isothiocyanate (MTPITC) to improve their controlled release for the inhibition of Staphylococcus aureus (S. aureus). These inclusion complexes were characterized using X-ray diffraction, Fourier-transform ...
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Intergenerational genetic programming mechanism and sex differences of the adrenal corticosterone synthesis dysfunction in offspring induced by prenatal ethanol exposureToxicology Letters (IF 4.271) Pub Date : 2021-08-25 ,DOI:10.1016/j.toxlet.2021.08.007Jiangang Cao, Yawen Chen, Xuan Xia, Hui Qu, Ying Ao, Hui WangWe previously found that prenatal ethanol exposure (PEE) induced adrenal dysplasia in offspring, which was related to intrauterine maternal glucocorticoid overexposure. This study investigated the intergenerational genetic effect and sex differences of PEE-induced changes in the synthetic function of adrenal corticosterone in offspring, and to clarify the intrauterine origin programming mechanism. ...
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The selection and identification of compound housekeeping genes for quantitative real-time polymerase chain reaction analysis in rat fetal kidneyJournal of Applied Toxicology (IF 3.628) Pub Date : 2021-08-10 ,DOI:10.1002/jat.4221Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Yi Liu, Lili Gao, Hui Wang, Ying AoDuring quantitative real-time polymerase chain reaction (RT-qPCR) data analysis, the selection of optimal housekeeping gene is necessary to ensure the accuracy of results. It is noteworthy that housekeeping genes commonly used in adult studies may not be applicable for fetus. However, the stability analysis of housekeeping gene in fetal kidney has not been reported. This study intends to screen the ...
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Crosslinked polyaniline nanorods coupled with molybdenum disulfide on functionalized carbon cloth for excellent electrochemical performanceJournal of Solid State Electrochemistry (IF 2.747) Pub Date : 2021-04-28 ,DOI:10.1007/s10008-021-04957-3Xinrong Lv, Yanfang Wang, Ying-ao Wang, Xiaoyun Lin, Yongnian NiIn this work, the binary nanocomposite of crosslinked polyaniline nanorods (CPANINRs) and molybdenum disulfide (MoS2) is first synthesized by in situ polymerization, and CPANINRs/MoS2 on functionalized carbon cloth (CPANINRs/MoS2/FCC) is facilely constructed by a drop-casting method. The composition, morphology, and structure of the CPANINRs, MoS2, and CPANINRs/MoS2 binary nanocomposite are characterized ...
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Exposure of pregnant rats to staphylococcal enterotoxin B increases offspring splenic Treg number and function via decreasing FoxP3 methylationImmunobiology (IF 3.152) Pub Date : 2021-01-23 ,DOI:10.1016/j.imbio.2021.152060Shu-xian Gao, Chao Sun, Yu-ting Zhu, Jia-bao Zhao, Jing Sun, Ping Zhou, Hao-yuan Jiang, Ying-ao Fan, Li Wei, Tao Zhang, Jun-chang GuanStaphylococcus aureus is an infectious pathogen that is relatively common, but that can cause severe disease in pregnant women and their fetus. We previously demonstrated that exposing pregnant rats to staphylococcal enterotoxin B (SEB) altered splenic CD4/CD8 T cell frequencies in their offspring. Whether prenatal SEB exposure impacts Tregs in these offspring, however, remains to be determined. As ...
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Unraveling the Hydroxide Ion Transportation Mechanism along the Surface of Two-Dimensional Layered Double Hydroxide NanosheetsThe Journal of Physical Chemistry C (IF 4.177) Pub Date : 2021-01-12 ,DOI:10.1021/acs.jpcc.0c09517Le Shi, Zhixuan Ying, Ao Xu, Yonghong ChengTraditional polymeric anion exchange membranes (AEMs) suffer from longstanding issues such as low ionic conductivities, poor stability, and high toxic preparation procedures. Recent experiments demonstrated that exfoliated two-dimensional layered double hydroxide (2D-LDH) could provide a super high hydroxide ion conductivity of about 0.1 S/cm, which is 1 to 2 orders of magnitude higher than that of ...
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Targeting senescent cell clearance: An approach to delay aging and age-associated disordersTranslational Medicine of Aging Pub Date : 2021-01-02 ,DOI:10.1016/j.tma.2020.12.001Zhengqi Qiu, Jiali Jia, Haoman Zou, Ying Ao, Baohua Liu, Zimei Wang
Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases and aging itself. Therefore, the targeted elimination of senescent cells may be beneficial for long-term human health in general. In this review, we summarize three key areas of recent research into the
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[The role of miRNA in kidney development].Yi chuan = Hereditas Pub Date : 2020-11-20 ,DOI:10.16288/j.yczz.20-112Xiao Qi Zhao,Ying Ao,Hai Yun Chen,Hui WangMicroRNAs (miRNAs) are endogenous small non-coding RNAs (19-25 nucleotides) that negatively regulate gene expression at the post transcriptional level by binding to complementary target sequences in the target mRNA. miRNAs play an important role in a wide range of biological processes, including organ development. Recent studies have shown that some miRNAs are highly expressed in the kidney and are ...
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Lamin A safeguards the m6 A methylase METTL14 nuclear speckle reservoir to prevent cellular senescence.Aging Cell (IF 11.005) Pub Date : 2020-08-19 ,DOI:10.1111/acel.13215Jie Zhang,Ying Ao,Zhen Zhang,Yanzhen Mo,Linyuan Peng,Yue Jiang,Zimei Wang,Baohua Liu
Mutations in LMNA gene are frequently identified in patients suffering from a genetic disorder known as Hutchison–Gilford progeria syndrome (HGPS), providing an ideal model for the understanding of the mechanisms of aging. Lamin A, encoded by LMNA, is an essential component of the subnuclear domain‒nuclear speckles; however, the functional significance in aging is unclear. Here, we show that Lamin
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China's practice to prevent and control COVID-19 in the context of large population movement.Infectious Diseases of Poverty (IF 10.485) Pub Date : 2020-08-19 ,DOI:10.1186/s40249-020-00716-0Tie-Long Xu,Mei-Ying Ao,Xu Zhou,Wei-Feng Zhu,He-Yun Nie,Jian-He Fang,Xin Sun,Bin Zheng,Xiao-Fan Chen
The emerging infectious disease, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a serious threat in China and worldwide. Challenged by this serious situation, China has taken many measures to contain its transmission. This study aims to systematically review and record these special and effective practices, in hope of benefiting for
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Unraveling the Water-Mediated Proton Conduction Mechanism along the Surface of Graphene OxideChemistry of Materials (IF 10.508) Pub Date : 2020-07-01 ,DOI:10.1021/acs.chemmater.0c01512Le Shi, Zhixuan Ying, Ao Xu, Yonghong ChengThe proton conduction capability of graphene oxide (GO) sheets opened up a new avenue for the design of high-performance solid-state electrolytes, which is urgently needed in areas such as fuel cells and flow batteries. However, the proton conduction mechanism of GO sheets is still unclear, impeding the optimization and further utilization of GO-based proton-conducting electrolytes. In this work, we ...
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PML2-mediated thread-like nuclear bodies mark late senescence in Hutchinson-Gilford progeria syndrome.Aging Cell (IF 11.005) Pub Date : 2020-04-29 ,DOI:10.1111/acel.13147Ming Wang,Lulu Wang,Minxian Qian,Xiaolong Tang,Zuojun Liu,Yiwei Lai,Ying Ao,Yinghua Huang,Yuan Meng,Lei Shi,Linyuan Peng,Xinyue Cao,Zimei Wang,Baoming Qin,Baohua Liu
Progerin accumulation disrupts nuclear lamina integrity and causes nuclear structure abnormalities, leading to premature aging, that is, Hutchinson–Gilford progeria syndrome (HGPS). The roles of nuclear subcompartments, such as PML nuclear bodies (PML NBs), in HGPS pathogenesis, are unclear. Here, we show that classical dot‐like PML NBs are reorganized into thread‐like structures in HGPS patient fibroblasts
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Prenatal ethanol exposure increased the susceptibility of adult offspring rats to glomerulosclerosisToxicology Letters (IF 4.271) Pub Date : 2020-03-01 ,DOI:10.1016/j.toxlet.2019.11.026Haiyun Chen, Yanan Zhu, Xiaoqi Zhao, Hangyuan He, Jinsong Luo, Ying Ao, Hui WangThis study was aimed to investigate the effect of prenatal ethanol exposure (PEE) on the susceptibility of offspring rats to glomerulosclerosis and to explore the mechanism. Pregnant Wistar rats were intragastrically administered ethanol (4g/kg·d) from gestational day (GD) 9 to GD 20, and the control group was given equal volume of normal saline. The offspring rats were all fed with high-fat diet after ...
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Anomalous proton conduction behavior across a nanoporous two-dimensional conjugated aromatic polymer membrane.Physical Chemistry Chemical Physics (IF 3.945) Pub Date : 2020-01-20 ,DOI:10.1039/c9cp06372bLe Shi,Zhixuan Ying,Ao Xu,Yonghong ChengWe investigate aqueous proton penetration behavior across a newly synthesized nanoporous two-dimensional conjugated aromatic polymer (2D-CAP) membrane using extensive ReaxFF reactive molecular dynamics simulations. We found that the proton penetration energy barrier across 2D-CAP is twice as high as that of graphtetrayne, even though 2D-CAP exhibits a larger pore size. Detailed analysis indicates that ...
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Prenatal dexamethasone exposure-induced a gender-difference and sustainable multi-organ damage in offspring rats via serum metabolic profile analysisToxicology Letters (IF 4.271) Pub Date : 2019-11-01 ,DOI:10.1016/j.toxlet.2019.09.007Guanghui Chen, Hao Xiao, Jinzhi Zhang, Huizhen Zhang, Bin Li, Tao Jiang, Yajie Wen, Yimin Jiang, Kaili Fu, Dan Xu, Yu Guo, Ying Ao, Huichang Bi, Hui WangPrenatal dexamethasone exposure (PDE) induces developmental toxicities of multiple organs in offspring, but its serum metabolic profile changes before and after birth are unclear. Here, we employed a LC-MS-based metabolomic approach to detect serum metabolites of PDE offspring rats in utero and adulthood, and explore its change characteristics and toxicological significances. Meanwhile, the bodyweight ...
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Decreased H3K9ac level of KLF4 mediates podocyte developmental toxicity induced by prenatal caffeine exposure in male offspring ratsToxicology Letters (IF 4.271) Pub Date : 2019-10-01 ,DOI:10.1016/j.toxlet.2019.07.011Yanan Zhu, Haiyun Chen, Xiaoqi Zhao, Bin Li, Hangyuan He, Hui Cheng, Hui Wang, Ying AoThis study aimed to verify the toxic effects of prenatal caffeine exposure (PCE) on the podocyte development in male offspring, and to explore the underlying intrauterine programming mechanisms. The pregnant rats were administered with caffeine (30 to 120 mg/kg⋅d) during gestational day (GD) 9 to 20. The male fetus on GD20 and the offspring at postnatal week (PW) 6 and PW28 were sacrificed. The results ...
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