- 作 者: "lian duan"
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Chinese moyamoya disease study: cohort profilemedRxiv - Neurology Pub Date : 2023-03-22 ,DOI:10.1101/2023.03.20.23287508Heguan Fu, JingJie Li, Zheng-shan Zhang, Xiang-Yang Bao, Jie Feng, Bin Li, Bin Ren, Hui Wang, Qian-Nan Wang, Songtao Pei, Bo Zhao, Zhenglong Zou, Yi-Qin Han, Huaiyu Tong, Zhenghui Sun, Miao Liu, Lian Duan
AbstractBackground: The etiology and natural course of moyamoya disease (MMD) remain unknown. This study evaluated the natural course and etiology of MMD using data from the Chinese MMD (C-MMD) cohort study.Methods: The C-MMD cohort consisted of 6,167 patients with MMD treated at our center over the past 20 years. We analyzed the medical history and laboratory and imaging examination results of the
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RADA-16-based self-assembled peptide nanofiber scaffolds loaded with TGF-β1 enhance the chondrogenic differentiation potential of BMSCs in vitroCurrent Stem Cell Research & Therapy (IF 3.758) Pub Date : 2023-03-17 ,DOI:10.2174/1574888x18666230316112847Dao-zhang Cai, Peng Yu, Lian Duan, Zhen Yan, Jun LiObjective: At present, cartilage repair does not offer ideal efficacy. Fortunately, recent studies have claimed that RADA-16 peptide is an attractive therapeutic strategy for repairing cartilage defects. Therefore, this study tried to explore the effect of RADA-16 loaded with transforming growth factor-beta (TGF-β) 1 on cartilage differentiation of bone marrow mesenchymal stem cells (BMSCs). Methods: ...
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Quinoxaline-based thermally activated delayed fluorescence emitters for highly efficient organic light emitting diodeJournal of Materials Chemistry C (IF 8.067) Pub Date : 2023-03-17 ,DOI:10.1039/d2tc04403jXiaoning Li, Yi Chen, Shuhui Li, Aisen Li, Liangjing Tu, Dongdong Zhang, Lian Duan, Yujun Xie, Ben-Zhong Tang, Zhen LiThermally activated delayed fluorescence (TADF) material is regarded as the most promising next generation emitters in organic light-emitting diodes (OLEDs). In this work, three TADF compounds are designed and synthesized based on acceptor of 1,2,3,4-tetrahydrophenazine and donors of 9,9-dimethyl-9,10-dihydroacridine (DMAC-TTPZ), phenoxazine (PXZ-TTPZ), and phenothiazine (PTZ-TTPZ). Wherein, cyclohexane ...
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A Simple Molecular Design Strategy for Pure-Red Multiple Resonance EmittersAngewandte Chemie International Edition (IF 16.823) Pub Date : 2023-03-14 ,DOI:10.1002/anie.202300934Haowen Chen, Tianjiao Fan, Guimin Zhao, Dongdong Zhang, Guomeng Li, Wei Jiang, Lian Duan, Yuewei ZhangThough the flourishment of materials with multiple resonance (MR) in blue to green regions, red-emissive MR emitters are still rare in literatures, which definitely should be resolved for further applications. Herein, we report a simple molecular design strategy for the construction of pure-red MR emitters by conjugate charge transfer, which could greatly enhance the π-conjugation degree and charge-transfer ...
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Effects of ionic polarizability and crystal structure on microwave dielectric properties of RE2O3 (RE = La, Eu) ceramics with opposite τf and high QJournal of the European Ceramic Society (IF 6.364) Pub Date : 2023-03-12 ,DOI:10.1016/j.jeurceramsoc.2023.03.028Lian Duan, Jiangyu Zhang, Jie Li, Huaicheng Xiang, Ying Tang, Xianrong Luo, Liang FangHexagonal La2O3 and monoclinic Eu2O3 ceramics were prepared, and their microwave dielectric properties were investigated. La2O3 sintered at 1400 °C exhibited promising microwave dielectric properties of εr = 18.6, Q×f = 71,400 GHz, and a negative τf of − 35.1 ppm/°C, while Eu2O3 sintered at 1500 °C possessed relative lower εr and Q×f values of 17.9 and 35,000 GHz, respectively, with an abnormally positive ...
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Exogenous hydrogen sulfide (H2S) exerts therapeutic potential in triple-negative breast cancer by affecting cell cycle and DNA replication pathwayBiomedicine & Pharmacotherapy (IF 7.419) Pub Date : 2023-03-10 ,DOI:10.1016/j.biopha.2023.114488Xiaoyue Cui, Rui Liu, Lian Duan, Qiaoling Zhang, Dan Cao, Aijie ZhangTriple negative breast cancer (TNBC) is a highly aggressive subtype with a poor prognosis due to its high rates of proliferation and metastasis. Recently, hydrogen sulfide (H2S) has been recognized as a novel gasotransmitter that plays a significant role in various pathological processes, including cancer. Here, we show that exogenous H2S inhibited TNBC cancer cell proliferation, migration and invasion ...
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Dissociated deficits of anticipated and experienced regret in at-risk suicidal individualsFrontiers in Psychiatry (IF 5.435) Pub Date : 2023-03-09 ,DOI:10.3389/fpsyt.2023.1121194Hui Ai, Lian Duan, Lin Huang, Yuejia Luo, André Aleman, Pengfei Xu
BackgroundsDecision-making deficits have been reported as trans-diagnostic characteristics of vulnerability to suicidal behaviors, independent of co-existing psychiatric disorders. Individuals with suicidal behaviors often regret their decision to attempt suicide and may have impairments in future-oriented processing. However, it is not clear how people with suicidal dispositions use future-oriented
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General toxicity and genotoxicity studies of a new scale inhibitor for seawater desalinationEnvironmental Sciences Europe (IF 5.481) Pub Date : 2023-03-09 ,DOI:10.1186/s12302-023-00722-7Lian Duan, Yimin Li, Wen Gu, Chao Wang, Ying Shi, Hongbin Yang, Mengmeng Wang, Yuehan Long, Song Tang, Jian Kong, Shaoping Zhang, Lixia Zhang, Lei Wei, Chong Wang, Kai LuMaleic acid polymer scale inhibitor is a new domestic seawater desalination scale inhibitor. This study tested the acute oral toxicity, sub-chronic toxicity and genotoxicity of this new inhibitor. The LD50 obtained from the acute oral toxicity test was 6810 and 9260 mg/kg·BW for male and female rats, as well as 1/5, 1/10 and 1/20 LD50 were as the dose for sub-chronic toxicity test. It showed the weight ...
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High-performance liquid chromatography-mass spectrometry-based metabolic profiling of adult growth hormone deficiency.The Journal of Clinical Endocrinology & Metabolism (IF 6.134) Pub Date : 2023-03-08 ,DOI:10.1210/clinem/dgad129Hongbo Yang,Meiping Chen,Yujie Wang,Lingjuan Jiang,Linjie Wang,Lian Duan,Fengying Gong,Huijuan Zhu,Hui Pan
CONTEXT Adult growth hormone deficiency (AGHD) is at increased risk of metabolic syndrome. Metabolic profiles in AGHD patients were insufficiently evaluated. PURPOSE To explore the serum metabolite profiles by metabolomics analysis and assess potential metabolites associated with recombinant human growth hormone (rhGH) treatment. METHODS Thirty-one AGHD patients and 31 healthy controls were enrolled
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High expression of PCOLCE gene indicate poor prognosis in patients and are associated with immune infiltration in gliomaScientific Reports (IF 4.996) Pub Date : 2023-03-07 ,DOI:10.1038/s41598-023-30413-5Qingbao Guo, Xin Gao, Jingjie Li, Yukun Liu, Jiayu Liu, Hui Yang, Meng Cui, Meng Zhang, Lian Duan, Xiaodong Ma
The procollagen C-protease enhancer (PCOLCE) has been identified to influence tumor growth and metastasis in multiple cancers. However, the relationship between PCOLCE activity and the progression of gliomas remains largely unknown. Glioma RNA-seq data were derived from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas databases for analysis. Kaplan–Meier survival curve, clinical characterization
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Complementary Inverter Based on n-Type and p-Type OFETs with the Same Ambipolar Organic Semiconductor and ITO S/D ElectrodesAdvanced Electronic Materials (IF 7.633) Pub Date : 2023-03-04 ,DOI:10.1002/aelm.202201288Jiangli Han, Xin Rong, Chenhui Xu, Yunfeng Deng, Yanhou Geng, Guifang Dong, Lian Duan
Bottom-gate and bottom-contact n-type and p-type organic field-effect transistors (OFETs) are simultaneously obtained by combining the ambipolar semiconductor film of diketopyrrolopyrrole-based conjugated polymer (P4FTVT-C32) with indium tin oxide (ITO) source/drain (S/D) electrodes. P4FTVT-C32 thin film exhibits n-type unipolar property with the low work functional (WF) ITO S/D electrodes modified
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Orbital Symmetry Engineering in Fused Polycyclic Heteroaromatics toward Extremely Narrowband Green Emissions with an FWHM of 13 nmAdvanced Materials (IF 32.086) Pub Date : 2023-03-01 ,DOI:10.1002/adma.202211316Xuan Zeng, Lu Wang, Hengyi Dai, Tianyu Huang, Mingxu Du, Dong Wang, Dongdong Zhang, Lian DuanMultiresonance (MR) molecules generally face spectral broadening issues with red-shifted emissions. Thus, green emitters with full width at half maximums (FWHMs) of <20 nm are rarely reported, despite being highly desired. Herein, by properly fusing indolo[3,2,1-jk]carbazole (ICZ) and naphthalene moieties, we report on green MR emitters with FWHMs of merely 13 nm (0.064 eV) and 14 nm (0.069 eV) in ...
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Direct Photo-Patterning of Efficient and Stable Quantum Dot Light-Emitting Diodes via Light-Triggered, Carbocation-Enabled Ligand StrippingNano Letters (IF 12.262) Pub Date : 2023-02-24 ,DOI:10.1021/acs.nanolett.3c00146Zhong Fu, Likuan Zhou, Yue Yin, Kangkang Weng, Fu Li, Shaoyong Lu, Dan Liu, Wenyong Liu, Longjia Wu, Yixing Yang, Haifang Li, Lian Duan, Hai Xiao, Hao Zhang, Jinghong LiNext generation displays based on quantum dot light-emitting diodes (QLEDs) require robust patterning methods for quantum dot layers. However, existing patterning methods mostly yield QLEDs with performance far inferior to the state-of-the-art individual devices. Here, we report a light-triggered, carbocation-enabled ligand stripping (CELS) approach to pattern QLEDs with high efficiency and stability ...
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Helically Chiral Donor–Acceptor Double Hetero[4]helicenes with Circularly Polarized Thermally Activated Delayed FluorescenceAdvanced Optical Materials (IF 10.05) Pub Date : 2023-02-19 ,DOI:10.1002/adom.202203030Cheng Qu, Yunlong Zhu, Lu Liang, Kaiqi Ye, Yuewei Zhang, Hongyu Zhang, Zuolun Zhang, Lian Duan, Yue WangAlthough helically chiral heterohelicenes are widely adopted in chiroptical studies, those with circularly polarized thermally activated delayed fluorescence (CP-TADF), which are highly valuable for circularly polarized organic light-emitting diodes (CP-OLEDs), are rarely realized. Moreover, the core skeletons of known CP-TADF heterohelicenes are limited to the p- and n-doped structures with multiresonance ...
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Diagnosis and Management of Idiopathic Hypothalamic Dysfunction: A Case Series and Systematic ReviewNeuroendocrinology (IF 5.135) Pub Date : 2023-02-06 ,DOI:10.1159/000529537Zhuoran Xu, Yawen Wang, Lian Duan, Yong Yao, Feng Feng, Linjie Wang, Kan Deng, Hui You, Hongbo Yang, Lin Lu, Huijuan Zhu
Introduction Idiopathic hypothalamic dysfunction (IHD) is a rare syndrome with heterogeneous clinical symptoms. This study aimed to systematically review the clinical features and potential treatment of IHD based on our case series and literature. Methods We analysed six recently diagnosed cases of IHD in Peking Union Medical College Hospital and conducted a systematic review of IHD case studies published
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Indole-fused BN-heteroarenes as narrowband blue emitters for organic light-emitting diodesJournal of Materials Chemistry C (IF 8.067) Pub Date : 2023-01-27 ,DOI:10.1039/d2tc04952jCheng-Zhuo Du, Yang Lv, Hengyi Dai, Xiangchen Hong, Jianping Zhou, Ji-Kun Li, Rong-Rong Gao, Dongdong Zhang, Lian Duan, Xiao-Ye WangA new family of indole-fused multi-resonance thermally activated delayed fluorescence materials have been developed, which exhibit narrowband blue emission with a small full width at half maximum of 22–23 nm. High maximum external quantum efficiencies of up to 16.8% have been achieved in organic light-emitting diodes. Furthermore, it is unveiled that peripheral substitutions can not only promote device ...
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Sub-macroscopic skin presentation of acromegaly and effect of pituitary tumor surgery: A study using dermatoscopy and ultra-high-frequency ultrasoundFrontiers in Endocrinology (IF 6.055) Pub Date : 2023-01-26 ,DOI:10.3389/fendo.2022.1093942Xiaopeng Guo, Yukun Wang, Yong Yao, Xinjie Bao, Lian Duan, Huijuan Zhu, Bing Xing, Jie Liu
ObjectiveExcessive growth hormone and insulin-like growth factor 1 contribute to cutaneous changes in acromegaly. We investigated the sub-macroscopic skin manifestation of acromegaly patients and explored its reversibility upon hormone reduction after pituitary adenoma surgery.DesignProspectively cohort study.MethodsWe enrolled 26 patients with acromegaly and 26 patients with non-functioning pituitary
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PM2.5-bound polycyclic aromatic hydrocarbons of a megacity in eastern China: Source apportionment and cancer risk assessmentScience of the Total Environment (IF 10.753) Pub Date : 2023-01-24 ,DOI:10.1016/j.scitotenv.2023.161792Lian Duan, Huimin Yu, Qiongzhen Wang, Yibo Cao, Guochen Wang, Xueshi Sun, Hao Li, Tian Lin, Zhigang GuoNinety-six fine particulate matter (PM2.5) samples covering four seasons from October 2020 to August 2021 were collected at a ‘super’ site in Hangzhou, a megacity in eastern China. These samples were analyzed to determine the sources and potential cancer risks to humans of 16 United States Environmental Protection Agency priority polycyclic aromatic hydrocarbons (PAHs). The average concentrations of ...
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Sub-macroscopic skin presentation of acromegaly and effect of pituitary tumor surgery: A study using dermatoscopy and ultra-high-frequency ultrasoundFrontiers in Endocrinology (IF 6.055) Pub Date : 2023-01-10 ,DOI:10.3389/fendo.2023.1093942Xiaopeng Guo, Yukun Wang, Yong Yao, Xinjie Bao, Lian Duan, Huijuan Zhu, Bing Xing, Jie Liu
ObjectiveExcessive growth hormone and insulin-like growth factor 1 contribute to cutaneous changes in acromegaly. We investigated the sub-macroscopic skin manifestation of acromegaly patients and explored its reversibility upon hormone reduction after pituitary adenoma surgery.DesignProspectively cohort study.MethodsWe enrolled 26 patients with acromegaly and 26 patients with non-functioning pituitary
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Machine learning for predicting accuracy of lung and liver tumor motion tracking using radiomic features.Quantitative Imaging in Medicine and Surgery Pub Date : 2023-01-09 ,DOI:10.21037/qims-22-621Guangjun Li,Xiangyu Zhang,Xinyu Song,Lian Duan,Guangyu Wang,Qing Xiao,Jing Li,Lan Liang,Long Bai,Sen Bai
Background Internal tumor motion is commonly predicted using external respiratory signals. However, the internal/external correlation is complex and patient-specific. The purpose of this study was to develop various models based on the radiomic features of computed tomography (CT) images to predict the accuracy of tumor motion tracking using external surrogates and to find accurate and reliable tracking
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Alterations in brain structure and function associated with pediatric growth hormone deficiency: A multi-modal magnetic resonance imaging studyFrontiers in Neuroscience (IF 5.152) Pub Date : 2023-01-06 ,DOI:10.3389/fnins.2022.1043857Zhibo Zhou, Yunyun Luo, Xiaoxing Gao, Yanlin Zhu, Xi Bai, Hongbo Yang, Qiuhui Bi, Shi Chen, Lian Duan, Linjie Wang, Fengying Gong, Feng Feng, Gaolang Gong, Huijuan Zhu, Hui Pan
IntroductionPediatric growth hormone deficiency (GHD) is a disease resulting from impaired growth hormone/insulin-like growth factor-1 (IGF-1) axis but the effects of GHD on children’s cognitive function, brain structure and brain function were not yet fully illustrated.MethodsFull Wechsler Intelligence Scales for Children, structural imaging, diffusion tensor imaging, and resting-state functional
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Highly Efficient and Stable Blue OLEDs Based on B—N Bonds Embedded 6,12-Diphenyl-5,11-dihydroindolo[3,2-b]carbazole with Narrowband Emission and Extended Lifetime†Chinese Journal of Chemistry (IF 5.56) Pub Date : 2022-12-22 ,DOI:10.1002/cjoc.202200693Hengyi Dai, Jianping Zhou, Guoyun Meng, Lu Wang, Lian Duan, Dongdong ZhangEmitters with narrowband spectra are of great importance nowadays because of the growing demand for ultra-high-definition displays in the fields of panel displays and solid-state lighting. Though the reported multiple resonance (MR) emitters have been widely studied with extremely sharp spectra and color-tunable emissions, the electrophilic borylation synthetic strategies and stable narrowband blue ...
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Wide-range color-tunable polycyclo-heteraborin multi-resonance emitters containing B–N covalent bondsChemical Science (IF 9.969) Pub Date : 2022-12-19 ,DOI:10.1039/d2sc06343cGuoyun Meng, Hengyi Dai, Jianping Zhou, Tianyu Huang, Xuan Zeng, Qi Wang, Xiang Wang, Yuewei Zhang, Tianjiao Fan, Dezhi Yang, Dongge Ma, Dongdong Zhang, Lian Duan
Boron- and nitrogen (BN)-fused polycyclic aromatic frameworks with amine-directed formation of B–N covalent bonds have the potential to form a new family of facile-synthesis multi-resonance luminophores, which, however, still face imperative challenges in diversifying the molecular design to narrow the emission bandwidth and tune the emission colors. Here, we demonstrate a strategic implementation
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Nitrogenous Interlayers for ITO S/D Electrodes in N-Type Organic Thin Film TransistorsAdvanced Materials Interfaces (IF 6.389) Pub Date : 2022-12-09 ,DOI:10.1002/admi.202202059Xin Rong, Jiangli Han, Chenhui Xu, Botai Ma, Lixian Jiang, Ding Ma, Rubo Xing, Liping Shen, Lian Duan, Yunfeng Deng, Yanhou Geng, Guifang DongThe commercialization of organic thin film transistors (OTFTs) is partly hindered by the high cost and stubborn work function (WF) of common Au source/drain (S/D) electrodes. In this work, indium tin oxide (ITO) S/D electrodes modified with three different nitrogenous interlayers including 1,4-bis(2-hydroxyethyl) piperazine (HEP), polyethylenimine ethoxylated (PEIE), and branched polyethylenimine (PEI) ...
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Machine Learning Radiomics Model for External and Internal Respiratory Motion Correlation Prediction in Lung TumorTechnology in Cancer Research & Treatment (IF 2.876) Pub Date : 2022-12-07 ,DOI:10.1177/15330338221143224Xiangyu Zhang, Xinyu Song, Guangjun Li, Lian Duan, Guangyu Wang, Guyu Dai, Ying Song, Jing Li, Sen BaiObjectives: The complexity and specificity of lung tumor motion render it necessary to determine the external and internal correlation individually before applying indirect tumor tracking. However,... ...
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Functional compounds of ginseng and ginseng-containing medicine for treating cardiovascular diseasesFrontiers in Pharmacology (IF 5.988) Pub Date : 2022-12-02 ,DOI:10.3389/fphar.2022.1034870Lanchun Liu, Jun Hu, Qiyuan Mao, Chao Liu, Haoqiang He, Xiaoshan Hui, Guang Yang, Peirong Qu, Wenjing Lian, Lian Duan, Yan Dong, Juhua Pan, Yongmei Liu, Qingyong He, Jun Li, Jie Wang
Ginseng (Panax ginseng C.A.Mey.) is the dry root and rhizome of the Araliaceae ginseng plant. It has always been used as a tonic in China for strengthening the body. Cardiovascular disease is still the main cause of death in the world. Some studies have shown that the functional components of ginseng can regulate the pathological process of various cardiovascular diseases through different mechanisms
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[Total Hip Arthroplasty in the Treatment of Dwarfism Complicated with Bilateral Hip Dysplasia:Report of One Case].Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae Pub Date : 2022-12-01 ,DOI:10.3881/j.issn.1000-503x.14900Lian Duan,Tuo Jiao,Zhi-Biao Jia,Kun FuThe clinical data of a female patient with dwarfism complicated with developmental dysplasia of the hip(DDH) treated in the Department of Joint Surgery of the First Affiliated Hospital of Hainan Medical College in September 2019 was analyzed.We summarized the experience in the treatment and reviewed the latest literature to determine the reasonable method for clinical diagnosis and treatment of dwarfism ...
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Combination of transsphenoidal endoscopic surgery and presurgical somatostatin analogs in thyrotropin (TSH)-secreting pituitary adenomas: Treatment outcome and long-term remission at a single pituitary centerFrontiers in Endocrinology (IF 6.055) Pub Date : 2022-11-28 ,DOI:10.3389/fendo.2022.1061029Jie Liu, Yamei Yang, Lian Duan, Xiaofeng Chai, Huijuan Zhu, Kan Deng, Xiaolan Lian, Yong Yao
BackgroundThyrotropin (TSH)-secreting pituitary adenomas (TSHomas) account for an extremely rare group of pituitary adenomas. Few studies examined the sensitivity and efficacy of presurgical somatostatin analogs (SSAs) and described the long-term remission under such treatment modality. The aim of the present study was to assess the efficacy of presurgical SSA treatment and long-term remission after
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Multiple Fusion Strategy for High-Performance Yellow OLEDs with Full Width at Half Maximums Down to 23 nm and External Quantum Efficiencies up to 37.4%Advanced Materials (IF 32.086) Pub Date : 2022-11-27 ,DOI:10.1002/adma.202209396Yuewei Zhang, Jinbei Wei, Lu Wang, Tianyu Huang, Guoyun Meng, Xiang Wang, Xuan Zeng, Mingxu Du, Tianjiao Fan, Chen Yin, Dongdong Zhang, Lian DuanThe pursuit of ideal narrowband yellow multiple resonance (MR) emitters is hampered by the mutual constraints of effective spectral redshift and maintaining a small full width at half maximum (FWHM) value. Here, a novel multiple fusion molecular design strategy is reported to break this trade-off. Compared with the selected narrowband parent core, the specific multiple MR effects in target molecules ...
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