- 作 者: ( "yuchen xia" OR "yu-chen xia" )
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Hepatitis B virus hijacks TSG101 to facilitate egress via multiple vesicle bodies.PLoS Pathogens (IF 7.464) Pub Date : 2023-05-24 ,DOI:10.1371/journal.ppat.1011382Yingcheng Zheng,Mengfei Wang,Sitong Li,Yanan Bu,Zaichao Xu,Guoguo Zhu,Chuanjian Wu,Kaitao Zhao,Aixin Li,Quan Chen,Jingjing Wang,Rong Hua,Yan Teng,Li Zhao,Xiaoming Cheng,Yuchen Xia
Hepatitis B virus (HBV) chronically infects 296 million individuals and there is no cure. As an important step of viral life cycle, the mechanisms of HBV egress remain poorly elucidated. With proteomic approach to identify capsid protein (HBc) associated host factors and siRNA screen, we uncovered tumor susceptibility gene 101 (TSG101). Knockdown of TSG101 in HBV-producing cells, HBV-infected cells
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m6A modification-tuned sphingolipid metabolism regulates postnatal liver development in male miceNature Metabolism (IF 19.865) Pub Date : 2023-05-15 ,DOI:10.1038/s42255-023-00808-9Shiguan Wang, Shanze Chen, Jianfeng Sun, Pan Han, Bowen Xu, Xinying Li, Youquan Zhong, Zaichao Xu, Peng Zhang, Ping Mi, Cuijuan Zhang, Lixiang Li, Haiyan Zhang, Yuchen Xia, Shiyang Li, Mathias Heikenwalder, Detian YuanDifferent organs undergo distinct transcriptional, epigenetic and physiological alterations that guarantee their functional maturation after birth. However, the roles of epitranscriptomic machineries in these processes have remained elusive. Here we demonstrate that expression of RNA methyltransferase enzymes Mettl3 and Mettl14 gradually declines during postnatal liver development in male mice. Liver-specific ...
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Antibiotic-induced gut bacteria depletion has no effect on HBV replication in HBV immune tolerance mouse modelVirologica Sinica (IF 6.947) Pub Date : 2023-05-02 ,DOI:10.1016/j.virs.2023.04.010Yanan Bu, Kaitao Zhao, Zaichao Xu, Yingcheng Zheng, Rong Hua, Chuanjian Wu, Chengliang Zhu, Yuchen Xia, Xiaoming Cheng
Commensal microbiota is closely related to Hepatitis B virus (HBV) infection. Gut bacteria maturation accelerates HBV immune clearance in hydrodynamic injection (HDI) HBV mouse model. However, the effect of gut bacteria on HBV replication in recombinant adeno-associated virus (AAV)-HBV mouse model with immune tolerance remains obscure. We aim to investigate its role on HBV replication in AAV-HBV mouse
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Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew modelsAntiviral Research (IF 10.103) Pub Date : 2023-05-02 ,DOI:10.1016/j.antiviral.2023.105618Junzhu Yi, Xinlin Lei, Fangteng Guo, Qiubing Chen, Xueyong Chen, Kaitao Zhao, Chengliang Zhu, Xiaoming Cheng, Jiangwei Lin, Hao Yin, Yuchen XiaWith 296 million chronically infected individuals worldwide, hepatitis B virus (HBV) causes a major health burden. The major challenge to cure HBV infection lies in the fact that the source of persistence infection, viral episomal covalently closed circular DNA (cccDNA), could not be targeted. In addition, HBV DNA integration, although normally results in replication-incompetent transcripts, considered ...
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Towards autonomous system: flexible modular production system enhanced with large language model agentsarXiv - EE - Systems and Control Pub Date : 2023-04-28 ,DOI:arxiv-2304.14721Yuchen Xia, Manthan Shenoy, Nasser Jazdi, Michael WeyrichIn this paper, we present a novel framework that combines large language models (LLMs), digital twins and industrial automation system to enable intelligent planning and control of production processes. Our approach involves developing a digital twin system that contains descriptive information about the production and retrofitting the automation system to offer unified interfaces of fine-granular ...
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Towards autonomous system: flexible modular production system enhanced with large language model agentsarXiv - CS - Systems and Control Pub Date : 2023-04-28 ,DOI:arxiv-2304.14721Yuchen Xia, Manthan Shenoy, Nasser Jazdi, Michael WeyrichIn this paper, we present a novel framework that combines large language models (LLMs), digital twins and industrial automation system to enable intelligent planning and control of production processes. Our approach involves developing a digital twin system that contains descriptive information about the production and retrofitting the automation system to offer unified interfaces of fine-granular ...
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Towards autonomous system: flexible modular production system enhanced with large language model agentsarXiv - CS - Software Engineering Pub Date : 2023-04-28 ,DOI:arxiv-2304.14721Yuchen Xia, Manthan Shenoy, Nasser Jazdi, Michael WeyrichIn this paper, we present a novel framework that combines large language models (LLMs), digital twins and industrial automation system to enable intelligent planning and control of production processes. Our approach involves developing a digital twin system that contains descriptive information about the production and retrofitting the automation system to offer unified interfaces of fine-granular ...
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Towards autonomous system: flexible modular production system enhanced with large language model agentsarXiv - CS - Robotics Pub Date : 2023-04-28 ,DOI:arxiv-2304.14721Yuchen Xia, Manthan Shenoy, Nasser Jazdi, Michael WeyrichIn this paper, we present a novel framework that combines large language models (LLMs), digital twins and industrial automation system to enable intelligent planning and control of production processes. Our approach involves developing a digital twin system that contains descriptive information about the production and retrofitting the automation system to offer unified interfaces of fine-granular ...
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Towards autonomous system: flexible modular production system enhanced with large language model agentsarXiv - CS - Computation and Language Pub Date : 2023-04-28 ,DOI:arxiv-2304.14721Yuchen Xia, Manthan Shenoy, Nasser Jazdi, Michael WeyrichIn this paper, we present a novel framework that combines large language models (LLMs), digital twins and industrial automation system to enable intelligent planning and control of production processes. Our approach involves developing a digital twin system that contains descriptive information about the production and retrofitting the automation system to offer unified interfaces of fine-granular ...
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Hepatitis B Virus Core Protein Is Not Required for Covalently Closed Circular DNA Transcriptional RegulationJournal of Virology (IF 6.549) Pub Date : 2022-10-13 ,DOI:10.1128/jvi.01362-22Youquan Zhong, Chuanjian Wu, Zaichao Xu, Yan Teng, Li Zhao, Kaitao Zhao, Jingjing Wang, Wen Wang, Qiong Zhan, Chengliang Zhu, Xinwen Chen, Kaiwei Liang, Xiaoming Cheng, Yuchen Xia aState Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy and Immunology, Institute of Medical Virology, TaiKang Center for Life and Medical Sciences, TaiKang Medical School, Wuhan Universitygrid.49470Journal of Virology, Ahead of Print. ...
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Adjustment Method of “FAST” Active Reflector Based on Optimal Fitting StrategyJournal of Function Spaces (IF 1.281) Pub Date : 2022-08-08 ,DOI:10.1155/2022/6994858Yu-Chen Xia
The adjustment method of the fast active reflector of “Chinese heavenly eye” is studied. Firstly, this paper studies the offset characteristics of fast main cable node position, combined with the position of the celestial body to be measured, the follow-up coordinate system is established, and the optimal fitting model of active reflector adjustment based on discrete main cable node is established
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Cmarr/miR-540-3p axis promotes cardiomyocyte maturation transition by orchestrating Dtna expressionMolecular Therapy - Nucleic Acids (IF 10.183) Pub Date : 2022-07-31 ,DOI:10.1016/j.omtn.2022.07.022Yukang Wu, Xudong Guo, Tong Han, Ke Feng, Peng Zhang, Yanxin Xu, Yiwei Yang, Yuchen Xia, Yang Chen, Jiajie Xi, Huangtian Yang, Xiaoping Wan, Jiuhong KangThe immature phenotype of embryonic stem cell-derived cardiomyocytes (ESC-CMs) limits their application. However, the molecular mechanisms of cardiomyocyte maturation remain largely unexplored. This study found that overexpression of long noncoding RNA (lncRNA)-Cmarr, which was highly expressed in cardiomyocytes, promoted the maturation change and physiological maturation of mouse ESC-CMs (mESC-CMs) ...
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Limited disassembly of cytoplasmic hepatitis B virus nucleocapsids restricts viral infection in murine hepatic cellsHepatology (IF 17.298) Pub Date : 2022-06-19 ,DOI:10.1002/hep.32622Kaitao Zhao, Fangteng Guo, Jingjing Wang, Youquan Zhong, Junzhu Yi, Yan Teng, Zaichao Xu, Li Zhao, Aixin Li, Zichen Wang, Xinwen Chen, Xiaoming Cheng, Yuchen XiaMurine hepatic cells cannot support hepatitis B virus (HBV) infection even with supplemental expression of viral receptor, human sodium taurocholate cotransporting polypeptide (hNTCP). However, the specific restricted step remains elusive. In this study, we aimed to dissect HBV infection process in murine hepatic cells. ...
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Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatmentAntiviral Research (IF 10.103) Pub Date : 2022-06-13 ,DOI:10.1016/j.antiviral.2022.105363Mingyuan Zhang, Haikun Zhang, Xiaoming Cheng, Xiaomei Wang, Hongqin Xu, Xiuzhu Gao, Ruihong Wu, Dake Zhang, Yuchen Xia, Junqi Niu
Aims Viral integration profiles attract increased interest in the study of HBV-related hepatocellular carcinoma (HCC), but their features in the early stage of infection and changes due to antiviral treatments remain largely unknown. Methods Liver biopsies and paired blood samples were obtained from HBeAg-positive patients before and after 48 weeks of entecavir treatment, and a probe-based capture
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LINC01431 Promotes Histone H4R3 Methylation to Impede HBV Covalently Closed Circular DNA Transcription by Stabilizing PRMT1Advanced Science (IF 17.521) Pub Date : 2022-04-10 ,DOI:10.1002/advs.202103135Yang Sun, Yan Teng, Liyuan Wang, Zhaoying Zhang, ChaoJia Chen, Yingchun Wang, Xiaodong Zhang, Peng Xiang, Xiaojia Song, Jinghui Lu, Nailin Li, Lifen Gao, Xiaohong Liang, Yuchen Xia, Zhuanchang Wu, Chunhong Ma
Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV), which interacts with both host and viral proteins to form minichromosome in the nucleus and is resistant to antiviral agents. Identification of host factors involved in cccDNA transcriptional regulation is expected to prove a new venue for HBV therapy. Recent evidence suggests the involvement of long
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Cpmer: A new conserved eEF1A2-binding partner that regulates Eomes translation and cardiomyocyte differentiationStem Cell Reports (IF 7.294) Pub Date : 2022-04-07 ,DOI:10.1016/j.stemcr.2022.03.006Yao Lyu, Wenwen Jia, Yukang Wu, Xin Zhao, Yuchen Xia, Xudong Guo, Jiuhong Kang
Previous studies have shown that eukaryotic elongation factor 1A2 (eEF1A2) serves as an essential heart-specific translation elongation element and that its mutation or knockout delays heart development and causes congenital heart disease and death among species. However, the function and regulatory mechanisms of eEF1A2 in mammalian heart development remain largely unknown. Here we identified the long
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Study on droplet transition behavior, bead geometric characteristics and formability of wire + arc additively manufactured Inconel 718 alloy by using CMT MIX+ Synchropulse processJournal of Materials Research and Technology (IF 6.267) Pub Date : 2022-02-03 ,DOI:10.1016/j.jmrt.2022.01.153Peng-Cheng Huan, Xiao-Nan Wang, Qing-Yu Zhang, Hong-Shuang Di, Xia-Ming Chen, Yu Chen, Xia Wei
In this paper, the droplet transfer behavior, geometric characteristics of weld bead and formability of CMT MIX+ Synchropulse (CSP) wire + arc additively manufactured Inconel 718 alloy under high wire feeding speed are studied. The results show that a CSP cycle is composed of a CSP high-frequency pulse stage (CSP-HFP) and CSP-CMT stage, and the periods ratio is about 1.7:1. The high frequency and large
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lncNBAT1/APOBEC3A is a mediator of HBX-induced chemoresistance in diffuse large B cell lymphoma cellsMolecular Therapy - Nucleic Acids (IF 10.183) Pub Date : 2022-01-25 ,DOI:10.1016/j.omtn.2022.01.015Jianguo Li, Yaqi Chen, Xuecong Guo, Xiaofei Bai, Xu Xu, Tong Han, Ailing Tan, Nana Liu, Yuchen Xia, Qiaoyi Sun, Xudong Guo, Jie Chen, Jiuhong Kang
Individuals with diffuse large B cell lymphoma (DLBCL) infected with hepatitis B virus (HBV) have worse chemotherapy efficacy and poorer outcomes. It is still unclear whether long noncoding RNAs (lncRNAs) serve as prognostic and therapeutic targets in the chemotherapy resistance of individuals with DLBCL and HBV infection. Here we found that the core component of HBV (HBX) directly upregulated the
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A Novel Mouse Model Harboring Hepatitis B Virus Covalently Closed Circular DNACellular and Molecular Gastroenterology and Hepatology (IF 8.797) Pub Date : 2021-12-09 ,DOI:10.1016/j.jcmgh.2021.11.011Zaichao Xu, Li Zhao, Youquan Zhong, Chengliang Zhu, Kaitao Zhao, Yan Teng, Xiaoming Cheng, Qiang Chen, Yuchen Xia
Background and Aims The persistence of viral covalently closed circular DNA (cccDNA) is the major obstacle for antiviral treatment against hepatitis B virus (HBV). Basic and translational studies are largely hampered due to the lack of feasible small animal models to support HBV cccDNA formation. The aim of this study is to establish a novel mouse model harboring cccDNA. Methods An adeno-associated
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Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar Lavage.Frontiers in Medicine (IF 5.058) Pub Date : 2021-09-07 ,DOI:10.3389/fmed.2021.690523Zhen Luo,Chengliang Zhu,Zhihui Ruan,Xianghua Cui,Muhammad Adnan Shereen,Pan Pan,Jingtao Huang,Fubing Wang,Hanwen Su,Yuchen Xia,Jianguo Wu
Objectives: The longitudinal characterization and risk of poor outcomes related to cytokine overproduction in critical coronavirus disease 2019 (COVID-19) patients with hyperinflammation in bronchoalveolar lavage requires further investigation. Methods: We enrolled two critically ill patients with comorbidities diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detected by
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SARS-CoV-2 NSP12 Protein Is Not an Interferon-β Antagonist.Journal of Virology (IF 6.549) Pub Date : 2021-08-10 ,DOI:10.1128/jvi.00747-21Aixin Li,Kaitao Zhao,Bei Zhang,Rong Hua,Yujie Fang,Wuhui Jiang,Jing Zhang,Lixia Hui,Yingcheng Zheng,Yan Li,Chengliang Zhu,Pei-Hui Wang,Ke Peng,Yuchen XiaThe coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is bringing an unprecedented health crisis to the world. To date, our understanding of the interaction between SARS-CoV-2 and host innate immunity is still limited. Previous studies reported that SARS-CoV-2 nonstructural protein 12 (NSP12) was able to suppress interferon-β (IFN-β) activation ...
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Novel function of SART1 in HNF4α transcriptional regulation contributes to its antiviral role during HBV infectionJournal of Hepatology (IF 30.083) Pub Date : 2021-07-07 ,DOI:10.1016/j.jhep.2021.06.038Yan Teng, Zaichao Xu, Kaitao Zhao, Youquan Zhong, Jingjing Wang, Li Zhao, Zhixin Zheng, Wei Hou, Chengliang Zhu, Xinwen Chen, Ulrike Protzer, Yong Li, Yuchen XiaBackground & Aims Our understanding of the interactions between HBV and its host cells is still quite limited. Spliceosome associated factor 1 (SART1) has recently been found to restrict HCV. Thus, we aimed to dissect its role in HBV infection. Methods SART1 was knocked down by RNA interference and over-expressed by lentiviral or adeno-associated virus (AAV) vectors in HBV-infected cell cultures and ...
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A Novel Biological Activity of the STAT3 Inhibitor Stattic in Inhibiting Glutathione Reductase and Suppressing the Tumorigenicity of Human Cervical Cancer Cells via a ROS-Dependent PathwayOncoTargets and Therapy (IF 4.345) Pub Date : 2021-07-05 ,DOI:10.2147/ott.s313507Yuchen Xia, Guihua Wang, Manli Jiang, Xueting Liu, Yan Zhao, Yinghui Song, Binyuan Jiang, Demao Zhu, Ling Hu, Zhao Zhang, Ting Cao, Ji Ming Wang, Jinyue Hu
Introduction: Glutathione reductase (GSR) provides reduced glutathione (GSH) to maintain redox homeostasis. Inhibition of GSR disrupts this balance, resulting in cell damage, which benefits cancer therapy. However, the effect of GSR inhibition on the tumorigenicity of human cervical cancer is not fully understood. Materials and Methods: Tissue microarray analysis was employed to determine GSR expression
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Structural Basis and Function of the N Terminus of SARS-CoV-2 Nonstructural Protein 1.Microbiology Spectrum Pub Date : 2021-06-16 ,DOI:10.1128/spectrum.00169-21Kaitao Zhao,Zunhui Ke,Hongbing Hu,Yahui Liu,Aixin Li,Rong Hua,Fangteng Guo,Junfeng Xiao,Yu Zhang,Ling Duan,Xin-Fu Yan,Yong-Gui Gao,Bing Liu,Yuchen Xia,Yan Li
Nonstructural protein 1 (Nsp1) of severe acute respiratory syndrome coronaviruses (SARS-CoVs) is an important pathogenic factor that inhibits host protein translation by means of its C terminus. However, its N-terminal function remains elusive. Here, we determined the crystal structure of the N terminus (amino acids [aa] 11 to 125) of SARS-CoV-2 Nsp1 at a 1.25-Å resolution. Further functional assays
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Interferon-induced degradation of the persistent hepatitis B virus cccDNA form depends on ISG20EMBO Reports (IF 9.071) Pub Date : 2021-05-09 ,DOI:10.15252/embr.201949568Daniela Stadler, Martin Kächele, Alisha N Jones, Julia Hess, Christian Urban, Jessica Schneider, Yuchen Xia, Andreas Oswald, Firat Nebioglu, Romina Bester, Felix Lasitschka, Marc Ringelhan, Chunkyu Ko, Wen-Min Chou, Arie Geerlof, Maarten A van de Klundert, Jochen M Wettengel, Peter Schirmacher, Mathias Heikenwälder, Sabrina Schreiner, Ralf Bartenschlager, Andreas Pichlmair, Michael Sattler, Kristian
Hepatitis B virus (HBV) persists by depositing a covalently closed circular DNA (cccDNA) in the nucleus of infected cells that cannot be targeted by available antivirals. Interferons can diminish HBV cccDNA via APOBEC3-mediated deamination. Here, we show that overexpression of APOBEC3A alone is not sufficient to reduce HBV cccDNA that requires additional treatment of cells with interferon indicating
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SARS-CoV-2 Antibody Seroprevalence in Wuhan, China, from 23 April to 24 May 2020mSphere (IF 5.029) Pub Date : 2021-04-21 ,DOI:10.1128/msphere.01062-20Huan Han, Junzhu Yi, Gongbo Cheng, Wuhui Jiang, Grzegorz M. Brożek, Yingan Jiang, Chengliang Zhu, Yuchen Xia, Nicole M. BouvierThe outbreak of coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in December 2019. To investigate the prevalence of COVID-19 in Wuhan, we conducted serologic tests on 35,326 individuals from four different communities to estimate cumulative incidence of infection. Our results showed that 1,332 individuals (3.77%) showed positive COVID-19 antibody (either IgM or IgG). Males had ...
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Seroprevalence of Anti-SARS-CoV-2 Antibodies in a Random Sample of Inhabitants of the Katowice Region, PolandInternational Journal of Environmental Research and Public Health (IF 4.614) Pub Date : 2021-03-19 ,DOI:10.3390/ijerph18063188Jan E. Zejda, Grzegorz M. Brożek, Małgorzata Kowalska, Kamil Barański, Angelina Kaleta-Pilarska, Artur Nowakowski, Yuchen Xia, Paweł Buszman
Lack of knowledge around seroprevalence levels of COVID-19 in Poland was the reason for the implementation of a seroepidemiological study in the Katowice Region (2,100,000 inhabitants). In October–November 2020, a questionnaire examination and measurement of anti-SARS-CoV-2 IgG and IgM antibodies were performed in a random sample of the general population (n = 1167). The objectives of the study were
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Issue CoverLiver International (IF 8.754) Pub Date : 2021-03-17 ,DOI:10.1111/liv.14872Rui Liu, Li Zhao, Xiaoming Cheng, Huan Han, Cong Li, Dong Li, Andrew Liu, Guosheng Gao, Feng Zhou, Fang Liu, Yingan Jiang, Chengliang Zhu, Yuchen Xia
The cover image is based on the Original Article Clinical characteristics of COVID‐19 patients with hepatitis B virus infection — a retrospective study by Rui Liu et al., https://doi.org/10.1111/liv.14774.
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Clinical characteristics of COVID‐19 patients with hepatitis B virus infection — a retrospective studyLiver International (IF 8.754) Pub Date : 2020-12-22 ,DOI:10.1111/liv.14774Rui Liu, Li Zhao, Xiaoming Cheng, Huan Han, Cong Li, Dong Li, Andrew Liu, Guosheng Gao, Feng Zhou, Fang Liu, Yingan Jiang, Chengliang Zhu, Yuchen Xia
The outbreak of coronavirus disease 2019 (COVID‐19) has been declared a pandemic. Although COVID‐19 is caused by infection in the respiratory tract, extrapulmonary manifestations including dysregulation of the immune system and hepatic injury have been observed. Given the high prevalence of hepatitis B virus (HBV) infection in China, we sought to study the impact of severe acute respiratory syndrome
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