- 作 者: ( "xulin jiang" OR "xu-lin jiang" )
-
Biodegradable photothermal thermosensitive hydrogels treat osteosarcoma by reprogramming macrophagesBiomaterials Science (IF 7.59) Pub Date : 2023-02-09 ,DOI:10.1039/d2bm01900kGuowen Luo, Ziyang Xu, Hua Zhong, Hongwei Shao, Hongyi Liao, Nan Liu, Xulin Jiang, Yu Zhang, Xiongfa JiOsteosarcoma is one of the most common malignant tumors in children and tends to occur around the knee. Problems such as recurrence and metastasis are the outcomes of traditional treatment methods. One of the reasons for these issues is the infiltration of tumor-associated macrophages (TAMs) in the tumor microenvironment (TME). Photothermal immunotherapy has emerged as one of the most potent approaches ...
-
Thermosensitive hydrogel for cartilage regeneration via synergistic delivery of SDF-1α like polypeptides and kartogeninCarbohydrate Polymers (IF 10.723) Pub Date : 2022-12-24 ,DOI:10.1016/j.carbpol.2022.120492Xi Yuan, Junlai Wan, Yang Yang, Long Huang, Chuankun Zhou, Jin Su, Shuaibin Hua, Hongxu Pu, Yi Zou, Hao Zhu, Xulin Jiang, Jun XiaoRegeneration of injured articular cartilage is limited by low early-stage recruitment of stem cells and insufficient chondrogenic differentiation. Hydrogels are widely used to repair cartilage because they have excellent mechanical and biological properties. In this study, a dual drug-loaded thermosensitive hydroxypropyl chitin hydrogel (HPCH) system was prepared to release stromal-derived factor-1α-like ...
-
Anxiety and sleep quality among front-line nurses treating first wave COVID-19 in China: The mediating role of mindfulnessArchives of Psychiatric Nursing (IF 2.242) Pub Date : 2022-09-16 ,DOI:10.1016/j.apnu.2022.09.007Xinyi Liu, Yingying Xu, Huiwen Xu, Lin Jiang, Ting Wang, Chen Chen, Amanda Lee, Pingting Zhu
Aim To explore anxiety, sleep quality, and mindfulness of frontline nurses at the initial epicenter of the pandemic, to examine the mediating effects of mindfulness. Background COVID-19 was first identified in Wuhan, China in January 2020. Nurses were at the forefront of care and treatment across hospitals in response to the pandemic. Methods Single site cross-sectional survey conducted in Wuhan province
...
-
Silver loaded biodegradable carboxymethyl chitin films with long-lasting antibacterial activity for infected wound healingBiomaterials Science (IF 7.59) Pub Date : 2022-08-15 ,DOI:10.1039/d2bm01046aSiyao Lv, Xulin JiangBacteria-related infections are one of the main causes of human skin infections, which are associated with the delay of wound healing and secondary complications. In this work, a series of novel biodegradable films based on thermosensitive carboxymethyl chitin were prepared without using any crosslinkers. All the carboxymethyl chitin films had good flexibility, high transparency, and appropriate water ...
-
Effects of chronic obstructive pulmonary disease on long-term prognosis of patients with coronary heart disease post-percutaneous coronary intervention.Journal of Geriatric Cardiology Pub Date : 2022-06-28 ,DOI:10.11909/j.issn.1671-5411.2022.06.005Yi Yao,Pei Zhu,Na Xu,Lin Jiang,Xiao-Fang Tang,Ying Song,Xue-Yan Zhao,Shu-Bin Qiao,Yue-Jin Yang,Jin-Qing Yuan,Run-Lin GaoBACKGROUND Chronic obstructive pulmonary disease (COPD) and cardiovascular diseases are often comorbid conditions, their co-occurrence yields worse outcomes than either condition alone. This study aimed to investigate COPD impacts on the five-year prognosis of patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI). METHODS Patients with CHD who underwent PCI in 2013 ...
-
Visualization of degradation of injectable thermosensitive hydroxypropyl chitin modified by aggregation-induced emissionCarbohydrate Polymers (IF 10.723) Pub Date : 2022-06-17 ,DOI:10.1016/j.carbpol.2022.119739Long Huang, Hejun Zhan, Xulin JiangThe reversible thermosensitive hydroxypropyl chitin (HPCH) has been widely investigated for drug delivery, tissue engineering, wound repair and antibacterial hemostasis. To achieve non-invasive and real-time visualization of in vivo degradation of HPCH, aggregation-induced emission fluorogen (AIEgen) was introduced covalently in HPCH in water to obtain thermosensitive fluorescent hydroxypropyl chitin ...
-
Bupivacaine-loaded hydroxypropyl chitin based sponges prepared via a solvent-free process provide long-acting local anesthesia for postoperative painJournal of Drug Delivery Science and Technology (IF 5.062) Pub Date : 2022-05-24 ,DOI:10.1016/j.jddst.2022.103453Fan Yang, Qianqian Qiao, Mingzhen Cai, Zhongyuan Xia, Xulin JiangLocal anesthetics have been extensively used in clinical practice to relieve the postoperative pain of patients. However, due to the short half-life of local anesthetics, a simple injection of local anesthetics cannot provide sufficient anesthetic effect for patients. It is important to develop a new delivery system for local drug administration to achieve an extended anesthetic effect without notable ...
-
A Temporal-Spatial Model Based Short-Term Power Load Forecasting Method in COVID-19 ContextFrontiers in Energy Research (IF 3.858) Pub Date : 2022-05-12 ,DOI:10.3389/fenrg.2022.923311Bowen Liu, Da Xu, Lin Jiang, Shuangyin Chen, Yong He
The worldwide coronavirus disease 2019 (COVID-19) pandemic has greatly affected the power system operations as a result of the great changes of socio-economic behaviours. This paper proposes a short-term load forecasting method in COVID-19 context based on temporal-spatial model. In the spatial scale, the cross-domain couplings analysis of multi-factor in COVID-19 dataset is performed by means of copula
...
-
Injectable immunomodulation-based porous chitosan microspheres/HPCH hydrogel composites as a controlled drug delivery system for osteochondral regenerationBiomaterials (IF 15.304) Pub Date : 2022-04-25 ,DOI:10.1016/j.biomaterials.2022.121530Xiongfa Ji, Hongwei Shao, Xiaohong Li, Muhammad Wajid Ullah, Guowen Luo, Ziyang Xu, Limin Ma, Xuecheng He, Zehua Lei, Qian Li, Xulin Jiang, Guang Yang, Yu ZhangThe inappropriate regenerated fibrous cartilage and subchondral bone of the injured chondral defect ultimately cause degeneration of the regenerated cartilage, which eventually leads to the failure of cartilage repair. In this study, we developed a macrophage-modulated and injectable ‘building block’ drug delivery system comprised of porous chitosan (CS) microspheres and hydroxypropyl chitin (HPCH) ...
-
Ropivacaine-loaded, hydroxypropyl chitin thermo-sensitive hydrogel combined with hyaluronan: an injectable, sustained-release system for providing long-lasting local anesthesia in ratsRegional Anesthesia & Pain Medicine (IF 5.564) Pub Date : 2022-04-01 ,DOI:10.1136/rapm-2021-102726Qianqian Qiao, Xiangyun Fu, Rui Huang, Shaoqing Lei, Yan Leng, Zhigang Liu, Zhongyuan Xia, Xulin JiangBackground and objective Ropivacaine hydrochloride is a commonly used local anesthetic in clinics. However, local injection or continuous infusion of ropivacaine has been associated with several disadvantages. Accordingly, it is important to develop a new controlled release system for local administration of ropivacaine to achieve a prolong anesthetic effect, improve efficacy, and minimize the side ...
-
Intra-articular injectable hydroxypropyl chitin/hyaluronic acid hydrogel as bio-lubricant to attenuate osteoarthritis progressionMaterials & Design (IF 9.417) Pub Date : 2022-04-01 ,DOI:10.1016/j.matdes.2022.110579Wenbin Liu, Mengsi Ma, Zehua Lei, Zixuan Xiong, Tenghui Tao, Pengfei Lei, Yihe Hu, Xulin Jiang, Jun Xiao
Osteoarthritis is a chronic degenerative joint disease and its signs of progress mainly attribute to the significant increase of joint friction and the destruction of articular cartilage. Combined cartilage repair and joint lubrication may be a feasible strategy for the treatment of osteoarthritis. In this study, the hydroxypropyl chitin (HPCH)/hyaluronic acid (HA) hydrogel, prepared by physical mixing
...
-
Biodegradable carboxymethyl chitin-based hemostatic sponges with high strength and shape memory for non-compressible hemorrhageCarbohydrate Polymers (IF 10.723) Pub Date : 2022-03-19 ,DOI:10.1016/j.carbpol.2022.119369Siyao Lv, Mingzhen Cai, Fan Leng, Xulin JiangUncontrolled hemorrhage of deep, narrow and non-compressible perforating wounds is responsible for many trauma deaths. In this work, a novel biodegradable hemostatic sponge based on thermosensitive carboxymethyl chitin was prepared via simple cryo-regeneration process without using any crosslinkers. The collagen and polydopamine were added to further enhance mechanical and hemostatic properties of ...
-
Huicore: A Generalized Hardware Accelerator for Complicated FunctionsIEEE Transactions on Circuits and Systems I: Regular Papers (IF 4.14) Pub Date : 2022-03-02 ,DOI:10.1109/tcsi.2022.3152799Hui Chen, Zongguang Yu, Jin Xu, Lin Jiang, Zhonghai Lu, Yuxiang Fu, Li LiEmerging advanced System-on-Chip (SoC) designs contain more and more complicated functions to be accelerated. This presents a challenge to conventional design approaches which use different hardware architectures or separate hardware accelerators to implement the various functions. To tackle this challenge, for the first time, we propose a generalized hardware accelerator called “Huicore” to speed ...
-
Size-tunable and biodegradable thrombin-functionalized carboxymethyl chitin microspheres for endovascular embolizationCarbohydrate Polymers (IF 10.723) Pub Date : 2022-02-23 ,DOI:10.1016/j.carbpol.2022.119274Fan Leng, Sai Lei, Bin Luo, Siyao Lv, Long Huang, Xulin JiangAs a minimally invasive method, endovascular embolization has been an effective strategy for controlling bleeding and tumor treatment. Herein, carboxymethyl chitin embolic microspheres were prepared with the aqueous two-phase carboxymethyl chitin/polyethylene glycol system without using any crosslinking agents and thrombin-functionalized embolic microsphere named as Thr@CMCHm-30 was made after covalent ...
-
Targeted and fluorescence traceable multifunctional host-guest supramolecular gene delivery platform based on poly(cyclodextrin) and rhodamine conjugated disulfide-containing azobenzene-terminated branched polymerInternational Journal of Polymeric Materials and Polymeric Biomaterials (IF 3.221) Pub Date : 2022-01-26 ,DOI:10.1080/00914037.2022.2029438Qimin Jiang, Shuyi Guan, Yunti Zhang, Yuhua Sun, Xulin JiangAbstract It is very challenging to fabricate a non-viral gene carrier system containing multifunctional components to overcome multiple extra- and intracellular barriers. Herein, we developed a novel PEGylated, targeted and fluorescence traceable multifunctional supramolecular host-guest gene vector system. This system was based on poly(β-cyclodextrin) (PCD), disulfide-containing azobenzene-terminated ...
-
Wood Dust Flammability Analysis by Microscale Combustion CalorimetryPolymers (IF 4.967) Pub Date : 2021-12-23 ,DOI:10.3390/polym14010045Qiang Xu, Lin Jiang, Andrea Majlingova, Nikoleta Ulbrikova, Rhoda Afriyie Mensah, Oisik Das, Filippo Berto
To study the practicability of a micro combustion calorimeter to analyze the calorimetry kinetics of wood, a micro combustion calorimeter with 13 heating rates from 0.1 to 5.5 K/s was used to perform the analysis of 10 kinds of common hardwood and softwood samples. As a microscale combustion measurement method, MCC (microscale combustion calorimetry) can be used to judge the flammability of materials
...
-
Wellbore temperature distribution during drilling of natural gas hydrate formation in South China seaPetroleum Pub Date : 2021-10-25 ,DOI:10.1016/j.petlm.2021.10.008Xiaolong Zhao, Yizhong Zhao, Zenglin Wang, Gang Chen, Peng Li, Wei Liang, Xuefeng Gao, Hanming Xu, Lin Jiang, Na Wei
The natural gas hydrate resources in the South China Sea alone are about 85 trillion cubic meters. In the drilling process of marine gas hydrate, the natural gas hydrate will decompose and produce gas, as the rising of temperature and dropping of the pressure in the annulus. This process will have a significant impact on drilling safety. Therefore, it is necessary to study the wellbore temperature
...
-
A novel gene expression signature-based on B-cell proportion to predict prognosis of patients with lung adenocarcinomaBMC Cancer (IF 4.638) Pub Date : 2021-10-12 ,DOI:10.1186/s12885-021-08805-5Zhang, Yi, Yin, Xuewen, Wang, Qi, Song, Xuming, Xia, Wenjie, Mao, Qixing, Chen, Bing, Liang, Yingkuan, Zhang, Te, Xu, Lin, Jiang, Feng, Xu, Xinyu, Dong, Gaochao
This study aimed to develop a reliable immune signature based on B-cell proportion to predict the prognosis and benefit of immunotherapy in LUAD. The proportion of immune cells in the TCGA-LUAD dataset was estimated using MCP-counter. The Least Absolute Shrinkage and Selector Operation was used to identify a prognostic signature and validated in an independent cohort. We used quantitative reverse
...
-
Modified porous carboxymethyl chitin microspheres by an organic solvent-free process for rapid hemostasisCarbohydrate Polymers (IF 10.723) Pub Date : 2021-06-17 ,DOI:10.1016/j.carbpol.2021.118348Fan Leng, Feixiang Chen, Xulin JiangRapid and effective hemorrhage control is essential to reduce mortality following traumatic injuries. Herein we developed an organic solvent-free process to prepare carboxymethyl chitin microsphere (CMCHm) in an aqueous two-phase system through heating and freeze-drying. To further enhance the hemostatic performance of CMCHm, we loaded calcium ions and in-situ polymerized dopamine to get modified hemostatic ...
-
Association of NPC1L1 and HMGCR Gene Polymorphisms with Major Adverse Cardiac and Cerebrovascular Events in Patients with Three-Vessel DiseaseHuman Gene Therapy (IF 4.793) Pub Date : 2021-06-16 ,DOI:10.1089/hum.2020.229Xueyan Zhao, Jiawen Li, Xiaofang Tang, Ru Liu, Jingjing Xu, Lianjun Xu, Lin Jiang, Keyong Huang, Jian Tian, Xinxing Feng, Yajie Wu, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing YuanThree-vessel disease (TVD) is a severe coronary heart disease (CHD) with poor prognosis. Niemann-Pick C1-like 1 (NPC1L1) is a transporter protein for exogenous cholesterol absorption, and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is a rate-limiting enzyme for cholesterol synthesis. We aimed to investigate the association between NPC1L1 and HMGCR gene polymorphisms and major adverse cardiac ...
-
Injectable hydroxypropyl chitin hydrogels embedded with carboxymethyl chitin microspheres prepared via a solvent-free process for drug deliveryJournal of Biomaterials Science, Polymer Edition (IF 3.682) Pub Date : 2021-05-26 ,DOI:10.1080/09205063.2021.1926893Jieyu Zheng, Siyao Lv, Yalan Zhong, Xulin JiangAbstract Microspheres and injectable hydrogels derived from natural biopolymers have been extensively investigated as controlled local drug delivery systems. In this study, we prepared carboxymethyl chitin microspheres (CMCH-Ms) with a diameter of 10–100 μm through physical crosslinking by increasing temperature in an aqueous two-phase system without using organic solvents, surfactants and crosslinking ...
-
An injectable photothermally active antibacterial composite hydroxypropyl chitin hydrogel for promoting the wound healing process through photobiomodulationJournal of Materials Chemistry B (IF 7.571) Pub Date : 2021-5-13 ,DOI:10.1039/d1tb00724fMengsi Ma, Yalan Zhong, Xulin JiangPrevention of bacterial infection, acceleration of wound closure and promotion of skin regeneration are crucial in the wound healing process. In this work, the photothermal activity of an injectable thermosensitive composite hydrogel based on hydroxypropyl chitin (HPCH), tannic acid (TA) and ferric ions (Fe3+) was studied. It was found that the photothermal efficiency was enhanced when the molar ratio ...
-
Magnetite drives self-dechlorination of 4-chlorophenol in anoxic aquatic sedimentsChemosphere (IF 8.943) Pub Date : 2021-01-18 ,DOI:10.1016/j.chemosphere.2021.129668Yang Li, Ying Ma, Zisheng Zhao, Xin Wen, Guangkuo Xu, Lin Jiang, Lifen Liu, Yaobin Zhang, Zhiqiang ZhaoThe lack of available electron donors is well known as a major factor limiting the efficiency of microbial dechlorination of 4-chlorophenol (4-CP) in anoxic aquatic sediments. Considering that Fe(III) minerals largely contained in sediments can especially enrich Fe(III)-reducing bacteria and unlock the ring-like intermediates produced by dechlorination of 4-CP via dissimilatory Fe(III) reduction, a ...
-
Real-world outcomes of different treatment strategies in patients with diabetes and three-vessel coronary disease: a mean follow-up 6.3 years study from ChinaCardiovascular Diabetology (IF 8.949) Pub Date : 2021-01-11 ,DOI:10.1186/s12933-020-01193-3Xueyan Zhao, Lianjun Xu, Lin Jiang, Jian Tian, Yin Zhang, Dong Wang, Kai Sun, Bo Xu, Wei Zhao, Rutai Hui, Runlin Gao, Lei Song, Jinqing Yuan
Patients with diabetes and triple-vessel disease (TVD) are associated with a high risk of events. The choice of treatment strategies remains a subject of discussion. In the real-world, we aim to compare the outcomes of medical therapy (MT), coronary artery bypass grafting (CABG), and percutaneous coronary intervention (PCI) treatment strategies in patients with diabetes and TVD. A total of 3117 consecutive
...
-
Correction to “Supramolecular Modular Approach toward Conveniently Constructing and Multifunctioning a pH/Redox Dual-Responsive Drug Delivery Nanoplatform for Improved Cancer Chemotherapy”ACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2020-12-24 ,DOI:10.1021/acsami.0c21677Jia Liu, Xingxin Liu, Ye Yuan, Qilin Li, Bingcheng Chang, Luming Xu, Bo Cai, Chao Qi, Cao Li, Xulin Jiang, Guobin Wang, Zheng Wang, Lin WangPages 26476 and 26479. The concentrations of NH4Cl and BSO used in this study were inaccurately presented. The concentrations of NH4Cl and BSO used in the intracellular drug release experiment should be 10 mM and 1 mM rather than 10 μM and 1 μM, respectively. The relevant text “To study the intracellular release mechanisms, HepG2 cells were treated with DOX@PRMSNs in the media containing NH4Cl (10 ...
-
Pyrolysis Kinetic Study and Reaction Mechanism of Epoxy Glass Fiber Reinforced Plastic by Thermogravimetric Analyzer (TG) and TG-FTIR (Fourier-Transform Infrared) Techniques.Polymers (IF 4.967) Pub Date : 2020-11-18 ,DOI:10.3390/polym12112739Yuanhua Qiao,Oisik Das,Shu-Na Zhao,Tong-Sheng Sun,Qiang Xu,Lin Jiang
TG-FTIR combined technology was used to study the degradation process and gas phase products of epoxy glass fiber reinforced plastic (glass fiber reinforced plastic) under the atmospheres of high purity nitrogen. The pyrolysis characteristics of epoxy glass fiber reinforced plastic were measured under different heating rates (5, 10, 15, 20 °C min-1) from 25 to 1000 °C. The thermogravimetric analyzer
...
-
A sequentially responsive nanosystem breaches cascaded bio-barriers and suppresses P-glycoprotein function for reversing cancer drug resistance.ACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2020-09-22 ,DOI:10.1021/acsami.0c13852Jia Liu,Lei Zhao,Lin Shi,Ye Yuan,Daan Fu,Zhilan Ye,Qilin Li,Yan Deng,Xingxin Liu,Qiying Lv,Yanni Cheng,Yunruo Xu,Xulin Jiang,Guobin Wang,Lin Wang,Zheng WangCancer chemotherapy is challenged by multidrug resistance (MDR) mainly attributed to overexpressed transmembrane efflux pump P-glycoprotein (P-gp) in cancer cells. Improving drug delivery efficacy while co-delivering P-gp inhibitors to suppress drug efflux is an often-used nanostrategy for combating MDR, which is however challenged by cascaded bio-barriers en route to cancer cells and P-gp inhibitors’ ...
-
IDO-inhibitor potentiated immunogenic chemotherapy abolishes primary tumor growth and eradicates metastatic lesions by targeting distinct compartments within tumor microenvironmentBiomaterials (IF 15.304) Pub Date : 2020-09-17 ,DOI:10.1016/j.biomaterials.2020.120388Qilin Li, Jia Liu, Huiling Fan, Lin Shi, Yan Deng, Lei Zhao, Mengxi Xiang, Yunruo Xu, Xulin Jiang, Guobin Wang, Lin Wang, Zheng WangImmunogenic chemotherapy (IC) is a type of chemotherapy where certain chemodrugs induce immunogenic cancer cell death (ICD), which in turn arouses T cell antitumor immunity. However, IC concurrently upregulates a key immune suppressor, indoleamine-2,3-dioxygenase (IDO), in both cancer cells and immune cells. IDO-mediated immunosuppression significantly offsets IC's therapeutic benefits in cancer patients ...
-
Thermosensitive Polysaccharide Hydrogel As a Versatile Platform for Prolonged Salmon Calcitonin Release and Calcium RegulationACS Biomaterials Science & Engineering (IF 5.395) Pub Date : 2020-06-03 ,DOI:10.1021/acsbiomaterials.0c00591Peng Yu, Yanpeng Liu, Ruitao Jin, Pan Zhang, Chunmei Ding, Xulin Jiang, Jiaqi Xing, Bo Bi, Jing Xie, Jianshu LiThe common pathological characteristic of osteoporosis and hypercalcemia is the disorder of calcium homeostasis. Currently, salmon calcitonin (sCT), a clinical regenerative medicine, is an attractive chioice to regulate calcium metabolism for alleviation of osteoporosis and hypercalcemia. Unfortunately, serum sCT is quickly cleared in vivo, leading to its short half-life. Here, we designed a versatile ...
-
Quantitative analysis of protein in thermosensitive hydroxypropyl chitin for biomedical applicationsAnalytical Biochemistry Pub Date : 2020-06-01 ,DOI:10.1016/j.ab.2020.113745Jiazhen Li, Yong Zhao, Xulin JiangAccurate determination of residual protein content in hydroxypropyl chitin (HPCH), a temperature-sensitive chitin derivative developed recently, is of great importance for biomedical applications. Coomassie brilliant blue (Bradford) method, Lowry method and Bicinchoninic acid (BCA) method were investigated to estimate the content of residual protein in HPCH. It was found that both Bradford and Lowry ...
广告：喜“文”乐“荐”|邀请好友使用Taylor & Francis Editing Services编辑润色服务，共享专属优惠！推荐人数无限制！
高级搜索
我的搜索条件
京公网安备 11010802027423号