- 作 者: "Clarke, Simon"
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Prospective comparison of two methods for assessing sarcopenia and interobserver agreement on retrospective CT imagesPostgraduate Medical Journal (IF 4.973) Pub Date : 2022-06-07 ,DOI:10.1136/postgradmedj-2021-141301Thomas Dale MacLaine, Oliver Baker, Miyuki Omura, Christopher Clarke, Simon J Howell, Dermot BurkePurpose of the study To compare the relationships between two CT derived sarcopenia assessment methods, and compare their relationship with inter-rater and intrarater validations and colorectal surgical outcomes. Study design 157 CT scans were identified across Leeds Teaching Hospitals National Health Service Trust for patients undergoing colorectal cancer surgery. 107 had body mass index data available ...
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Drivers of Anaerobic Methanogenesis in Sub-Tropical Reservoir SedimentsFrontiers in Environmental Science (IF 5.411) Pub Date : 2022-05-31 ,DOI:10.3389/fenvs.2022.852344Alistair Grinham, Cathryn O’Sullivan, Matthew Dunbabin, Katrin Sturm, Deborah Gale, William Clarke, Simon Albert
Anaerobic methanogenesis is dependent on key macronutrients (carbon, nitrogen and phosphorus) and trace metals (including iron, nickel and cobalt) to drive methane production. Reservoir derived methane emissions have correlated to eutrophication status, with elevated emissions associated with more eutrophic systems. Additionally, sediment organic matter can enhance methane emissions, particularly through
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Visualising health risks with medical imaging for changing recipients' health behaviours and risk factors: Systematic review with meta-analysis.PLOS Medicine (IF 11.613) Pub Date : 2022-03-03 ,DOI:10.1371/journal.pmed.1003920Gareth J Hollands,Juliet A Usher-Smith,Rana Hasan,Florence Alexander,Natasha Clarke,Simon J Griffin
BACKGROUND There is ongoing clinical and research interest in determining whether providing personalised risk information could motivate risk-reducing health behaviours. We aimed to assess the impact on behaviours and risk factors of feeding back to individuals' images of their bodies generated via medical imaging technologies in assessing their current disease status or risk. METHODS AND FINDINGS
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A standard enteral formula versus an iso-caloric lower carbohydrate/high fat enteral formula in the hospital management of adolescent and young adults admitted with anorexia nervosa: a randomised controlled trialJournal of Eating Disorders (IF 4.916) Pub Date : 2021-12-11 ,DOI:10.1186/s40337-021-00513-6Parker, Elizabeth Kumiko, Flood, Victoria, Halaki, Mark, Wearne, Christine, Anderson, Gail, Gomes, Linette, Clarke, Simon, Wilson, Frances, Russell, Janice, Frig, Elizabeth, Kohn, Michael
The nutritional rehabilitation of malnourished patients hospitalised with anorexia nervosa is essential. The provision of adequate nutrition must occur, while simultaneously, minimising the risk of refeeding complications, such as electrolyte, metabolic, and organ dysfunction. The aim of this study was to compare the efficacy and safety of an iso-caloric lower carbohydrate/high fat enteral formula
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The environmental consequences of a change in Australian cotton lint productionThe International Journal of Life Cycle Assessment (IF 5.257) Pub Date : 2021-11-09 ,DOI:10.1007/s11367-021-01994-yNguyen, Quan V., Wiedemann, Stephen G., Simmons, Aaron, Clarke, Simon J.Purpose Changes in the production of Australian cotton lint are expected to have a direct environmental impact, as well as indirect impacts related to co-product substitution and induced changes in crop production. The environmental consequences of a 50% expansion or contraction in production were compared to Australian cotton production’s current environmental footprint. Both were then assessed to ...
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MRI Patterns Distinguish AQP4 Antibody Positive Neuromyelitis Optica Spectrum Disorder From Multiple Sclerosis.Frontiers in Neurology (IF 4.086) Pub Date : 2021-09-09 ,DOI:10.3389/fneur.2021.722237Laura Clarke,Simon Arnett,Wajih Bukhari,Elham Khalilidehkordi,Sofia Jimenez Sanchez,Cullen O'Gorman,Jing Sun,Kerri M Prain,Mark Woodhall,Roger Silvestrini,Christine S Bundell,David A Abernethy,Sandeep Bhuta,Stefan Blum,Mike Boggild,Karyn Boundy,Bruce J Brew,Wallace Brownlee,Helmut Butzkueven,William M Carroll,Cella Chen,Alan Coulthard,Russell C Dale,Chandi Das,Marzena J Fabis-Pedrini,David Gillis,Simon
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory diseases of the CNS. Overlap in the clinical and MRI features of NMOSD and MS means that distinguishing these conditions can be difficult. With the aim of evaluating the diagnostic utility of MRI features in distinguishing NMOSD from MS, we have conducted a cross-sectional analysis of imaging data and developed
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Magnetic resonance imaging in neuromyelitis optica spectrum disorderClinical & Experimental Immunology (IF 5.732) Pub Date : 2021-06-02 ,DOI:10.1111/cei.13630Laura Clarke, Simon Arnett, Kate Lilley, Jacky Liao, Sandeep Bhuta, Simon A Broadley
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) associated with antibodies to aquaporin-4 (AQP4), which has distinct clinical, radiological and pathological features, but also has some overlap with multiple sclerosis and myelin oligodendrocyte glycoprotein (MOG) antibody associated disease. Early recognition of NMOSD is important because
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Brief report: Passive mechanical properties of gastrocnemius in multiple sclerosis and ankle contractureClinical Biomechanics (IF 2.034) Pub Date : 2021-03-23 ,DOI:10.1016/j.clinbiomech.2021.105338Phu D. Hoang, Michael Psarakis, Li Khim Kwah, Jillian L. Clarke, Simon C. Gandevia, Joanna DiongBackground Ankle contracture is common in people with multiple sclerosis (MS) but the mechanisms of contracture are not clear. This study aimed to identify the mechanisms of contracture in MS by comparing passive muscle length and stiffness at known tension, separated into contributions by muscle fascicles and tendons, between people with MS who had contracture and healthy people. Methods Passive length-tension ...
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The Indications for Elective Neck Dissection in T1N0M0 Oral Cavity Squamous Cell CarcinomaJournal of Oral and Maxillofacial Surgery (IF 2.136) Pub Date : 2021-02-24 ,DOI:10.1016/j.joms.2021.01.042Edward Nguyen, Jamie McKenzie, Rachel Clarke, Simon Lou, Thasvir SinghPurpose The management of the clinically node-negative neck in T1 oral cavity squamous cell carcinoma (SCC) is controversial. The purpose of this study was to investigate tumor characteristics of surgically managed patients with T1N0 oral cavity SCC and determine the possible benefits of elective neck dissection (END). Materials and Methods A retrospective cohort study was conducted assessing outcomes ...
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Health literacy impacts self-management, quality of life and fear of recurrence in head and neck cancer survivorsJournal of Cancer Survivorship (IF 4.062) Pub Date : 2021-01-09 ,DOI:10.1007/s11764-020-00978-5Nicholas Clarke, Simon Dunne, Laura Coffey, Linda Sharp, Deirdre Desmond, Jean O’Conner, Eleanor O’Sullivan, Conrad Timon, Claire Cullen, Pamela GallagherPurpose Little is known about whether health literacy is associated with affects certain key outcomes in head and neck cancer (HNC) survivors. We investigated (i) the socio-demographic and clinical profile of health literacy and (ii) associations among between health literacy and self-management behaviours, health-related quality of life (HRQL) and fear of recurrence (FoR) in HNC survivors. Methods ...
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Development and Application of a Prioritization Tool for Animal Health Surveillance Activities in IrelandFrontiers in Veterinary Science (IF 3.471) Pub Date : 2020-12-02 ,DOI:10.3389/fvets.2020.596867AnneMarie Clarke, Simon J. More, James W. Maher, Andrew W. Byrne, Michael Horan, Damien Barrett
Decisions around animal health management by stakeholders are often subject to resource limitation, therefore prioritization processes are required to evaluate whether effort is attributed appropriately. The objectives of this study were to develop and apply a surveillance prioritization process for animal health surveillance activities in Ireland. An exploratory sequential mixed research methods design
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Treatment of hallux valgus by Scarf osteotomy – rates and reasons for recurrence and rates of avascular necrosis: A systematic reviewFoot and Ankle Surgery (IF 2.84) Pub Date : 2020-08-27 ,DOI:10.1016/j.fas.2020.08.009Thomas A.C. Clarke, Simon R. PlattDepartment of Musculoskeletal Services - Surgical, Anaesthetics and Procedural Services (SaPS), Gold Coast University Hospital, Gold Coast Health, 1 Hospital Boulevard, Southport, Queensland 4215, Australia.Background We reviewed the rates of and reasons for hallux valgus (HV) recurrence and the rates of avascular necrosis following Scarf osteotomy. Methods We searched the Cochrane Library, PubMed, and Embase databases for studies reporting operative management of HV using Scarf osteotomy. The primary endpoints were reasons for and rates of HV recurrence. The secondary endpoint was the rate of avascular ...
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A Potent Fuel? Faith Identity and Development Impact in World Vision Community ProgrammingJournal of International Development (IF 1.537) Pub Date : 2020-08-24 ,DOI:10.1002/jid.3512Michael Jennings, Matthew Clarke, Simon Feeny, Gill Westhorp, Cara Donohue
This paper explores the role of faith identity on impact in development by looking at the programming of a major international faith‐based development organisation (FBDO). It argues that faith identity rests not only in the internal projected identity of the FBDO but also on perceptions of that identity in the community, highlighting the role context plays in the formulation of faith identity and its
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Single‐session Comprehend, Cope, and Connect intervention in acute and crisis psychology: A feasibility and acceptability studyClinical Psychology & Psychotherapy (IF 3.198) Pub Date : 2020-08-24 ,DOI:10.1002/cpp.2505Jonathan Bullock, Christopher Whiteley, Kaylee Moakes, Isabel Clarke, Simon RichesComprehend, Cope, and Connect (CCC) is a third‐wave cognitive behavioural approach developed for acute mental health services. The aim of this study was to assess feasibility and acceptability of a newly developed, manualized single‐session CCC intervention delivered face‐to‐face with service users in acute and crisis psychology services in South London. The study adopted a within‐subjects pre‐post‐test ...
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Relapse Patterns in NMOSD: Evidence for Earlier Occurrence of Optic Neuritis and Possible Seasonal Variation.Frontiers in Neurology (IF 4.086) Pub Date : 2020-06-16 ,DOI:10.3389/fneur.2020.00537Elham Khalilidehkordi,Laura Clarke,Simon Arnett,Wajih Bukhari,Sofia Jimenez Sanchez,Cullen O'Gorman,Jing Sun,Kerri M Prain,Mark Woodhall,Roger Silvestrini,Christine S Bundell,David Abernethy,Sandeep Bhuta,Stefan Blum,Mike Boggild,Karyn Boundy,Bruce J Brew,Matthew Brown,Wallace Brownlee,Helmut Butzkueven,William M Carroll,Celia Chen,Alan Coulthard,Russell C Dale,Chandi Das,Marzena J Fabis-Pedrini,David
Neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) show overlap in their clinical features. We performed an analysis of relapses with the aim of determining differences between the two conditions. Cases of NMOSD and age- and sex-matched MS controls were collected from across Australia and New Zealand. Demographic and clinical information, including relapse histories, were recorded
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Changing the Paradigm of Surgical Research During a Pandemic.Annals of Surgery (IF 13.787) Pub Date : 2020-05-01 ,DOI:10.1097/sla.0000000000004000Sheraz R Markar,Guy Martin,Marta Penna,Seema Yalamanchili,Jasmine Winter Beatty,Jonathan Clarke,Simon Erridge,Viknesh Sounderajah,Max Denning,Alasdair Scott,Sanjay Purkayastha,James Kinross,
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Copper-Oxide-Coated Silver Nanodendrites for Photoelectrocatalytic CO2 Reduction to Acetate at Low OverpotentialACS Applied Energy Materials (IF 6.959) Pub Date : 2020-03-11 ,DOI:10.1021/acsanm.0c00210Esteban Laeta, Rafael A. Masitas, Thomas B. Clarke, Simon Rafacz, Darby A. Nelson, Mauricio Isaacs, Zachary D. SchultzThe photoelectrocatalytic reduction of CO2 uses sunlight to reduce the external energy needed to convert this greenhouse gas into value-added products. We report the deposition of a thin film of copper oxide onto a large-surface-area plasmonic silver structure, which generates an efficient photoelectrocatalyst for CO2 reduction. Using incoherent visible light illumination and applying −0.4 V versus ...
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Copper-Oxide-Coated Silver Nanodendrites for Photoelectrocatalytic CO2 Reduction to Acetate at Low OverpotentialACS Applied Nano Materials (IF 6.14) Pub Date : 2020-03-11 ,DOI:10.1021/acsanm.0c00210Esteban Landaeta, Rafael A. Masitas, Thomas B. Clarke, Simon Rafacz, Darby A. Nelson, Mauricio Isaacs, Zachary D. SchultzThe photoelectrocatalytic reduction of CO2 uses sunlight to reduce the external energy needed to convert this greenhouse gas into value-added products. We report the deposition of a thin film of copper oxide onto a large-surface-area plasmonic silver structure, which generates an efficient photoelectrocatalyst for CO2 reduction. Using incoherent visible light illumination and applying −0.4 V versus ...
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Neighborhood crime, disorder and substance use in the Caribbean context: Jamaica National Drug Use Prevalence Survey 2016.PLOS ONE (IF 3.752) Pub Date : 2019-11-23 ,DOI:10.1371/journal.pone.0224516Erica Ann Felker-Kantor,Colette Cunningham-Myrie,Lisa-Gaye Greene,Parris Lyew-Ayee,Uki Atkinson,Wendel Abel,Pernell Clarke,Simon G Anderson,Katherine P Theall
The purpose of the study was to examine the role of objective and subjective measures of neighborhood crime and disorder on substance use among a nationally representative sample of 4525 Jamaicans aged 12-65 years. Log-Poisson models with generalized estimating equations were used to estimate relative risks (RR) and 95% confidence intervals (CI). A test of interaction was used to determine presence
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Clinical significance of alloantibodies in hand transplantation – a multicenter studyTransplantation (IF 5.385) Pub Date : 2019-10-01 ,DOI:10.1097/tp.0000000000002650Jan Kowalski, Gerald Brandacher, Dorota Kamińska, Christina L. Kaufman, Simon G. Talbot, Kodi Azari, Luis Landin, Christoph Höhnke, Karen M. Dwyer, Pedro C. Cavadas, Alessandro Thione, Brendan Clarke, Simon Kay, Dan Wilks, Subramania Iyer, Martin Iglesias, Ömer Özkan, Özlenen Özkan, Johanna Krapf, Annemarie Weissenbacher, Palmina Petruzzo, Stefan SchneebergerBACKGROUND Donor-specific antibodies (DSA) have a strong negative correlation with long-term survival in solid organ transplantation. Although the clinical significance of DSA and antibody-mediated rejection (AMR) in upper extremity transplantation (UET) remains to be established, a growing number of single-center reports indicate their presence and potential clinical impact. METHODS We present a multicenter ...
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A novel patient-specific instrument design can deliver robotic level accuracy in unicompartmental knee arthroplasty.The Knee (IF 2.423) Pub Date : 2019-09-10 ,DOI:10.1016/j.knee.2019.08.001Gareth G Jones,Susannah Clarke,Simon Harris,Martin Jaere,Thunayan Aldalmani,Patrick de Klee,Justin P CobbBACKGROUND A previous randomised controlled trial (RCT) by our group found that robotic assisted unicompartmental knee arthroplasty (UKA) surgery was significantly more accurate than conventional instrumentation. The aim of this study was to determine whether a low-cost novel PSI design could deliver the same level of accuracy as the robot in the same time efficient manner as conventional instruments ...
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Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in GranulocytesInternational Journal of Molecular Sciences (IF 4.556) Pub Date : 2019-08-19 ,DOI:10.3390/ijms20164046Valerie R. Wiersma, Alex Clarke, Simon D. Pouwels, Elizabeth Perry, Trefa M. Abdullah, Clive Kelly, Anthony De Soyza, David Hutchinson, Paul Eggleton, Edwin Bremer
The aetiology of rheumatoid arthritis (RA) is unknown, but citrullination of proteins is thought to be an initiating event. In addition, it is increasingly evident that the lung can be a potential site for the generation of autoimmune triggers before the development of joint disease. Here, we identified that serum levels of galectin-9 (Gal-9), a pleiotropic immunomodulatory protein, are elevated in
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Galectin-9 Is a Possible Promoter of Immunopathology in Rheumatoid Arthritis by Activation of Peptidyl Arginine Deiminase 4 (PAD-4) in Granulocytes.International Journal of Molecular Sciences Pub Date : 2019-08-19 ,DOI:10.3390/ijms20164046Valerie R Wiersma,Alex Clarke,Simon D Pouwels,Elizabeth Perry,Trefa M Abdullah,Clive Kelly,Anthony De Soyza,David Hutchinson,Paul Eggleton,Edwin Bremer
The aetiology of rheumatoid arthritis (RA) is unknown, but citrullination of proteins is thought to be an initiating event. In addition, it is increasingly evident that the lung can be a potential site for the generation of autoimmune triggers before the development of joint disease. Here, we identified that serum levels of galectin-9 (Gal-9), a pleiotropic immunomodulatory protein, are elevated in
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A single-use, size-specific, nylon arthroplasty guide: a preliminary study for hip resurfacing.Hip International (IF 1.756) Pub Date : 2019-04-04 ,DOI:10.1177/1120700019834918Keisuke Uemura,Oliver R Boughton,Kartik Logishetty,Camilla Halewood,Susannah G Clarke,Simon J Harris,Nobuhiko Sugano,Justin P CobbINTRODUCTION In arthroplasty surgery, positioning of the components must be accurate and reproducible to avoid complications. Conventional guides are often used to align a component, but they require surgical skill and experience, and are prone to error. To this end, a single-use, size-specific, nylon guide (single-use nylon guide) has been developed for the purpose of increasing the accuracy without ...
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Secondary free tissue transfer in head and neck reconstruction.Journal of Plastic, Reconstructive & Aesthetic Surgery (IF 3.022) Pub Date : 2019-03-09 ,DOI:10.1016/j.bjps.2019.02.015Sarita V Vamadeva,Francis P Henry,Alasdair Mace,Peter M Clarke,Simon H Wood,Navid JallaliBACKGROUND The incidence of head and neck cancer (H&N) continues to increase together with the need for reconstructive surgery. Head and Neck microsurgeons are likely to encounter challenging secondary free flap surgery on the background of failed primary flaps, radiotherapy treatment or recurrence. The aim of this study was to review our experience of treating such cases in a tertiary referral centre ...
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Chromatin-Based Classification of Genetically Heterogeneous AMLs into Two Distinct Subtypes with Diverse Stemness Phenotypes.Cell Reports (IF 9.995) Pub Date : 2019-Jan-2 ,DOI:10.1016/j.celrep.2018.12.098Petraglia,Pankaj Narang,Eva M. Janssen-Megens,Amit Mandoli,Angelika Merkel,Kim Berentsen,Bowon Kim,Filomena Matarese,Abhishek A. Singh,Ehsan Habibi,Koen H.M. Prange,André B. Mulder,Joop H. Jansen,Laura Clarke,Simon Heath,Bert A. van der Reijden,Paul Flicek,Marie-Laure Yaspo,Ivo Gut,Christoph Bock,Jan Jacob Schuringa,Lucia Altucci,Edo Vellenga,Hendrik G. Stunnenberg,Joost H.A. Martens
Global investigation of histone marks in acute myeloid leukemia (AML) remains limited. Analyses of 38 AML samples through integrated transcriptional and chromatin mark analysis exposes 2 major subtypes. One subtype is dominated by patients with NPM1 mutations or MLL-fusion genes, shows activation of the regulatory pathways involving HOX-family genes as targets, and displays high self-renewal capacity
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Measuring Tibial Component Rotation Following Total Knee Arthroplasty: What Is the Best Method?The Journal of Arthroplasty (IF 4.435) Pub Date : 2018-10-27 ,DOI:10.1016/j.arth.2018.10.022Mustafa Saffi,Mark J Spangehl,Henry D Clarke,Simon W YoungBACKGROUND Tibial component malrotation is associated with pain, stiffness, and altered patellofemoral kinematics in total knee arthroplasty (TKA). However, measuring tibial component rotation following TKA is difficult. Proposed protocols utilizing computed tomography (CT) lack validity and can be time-consuming. This study aimed to (1) compare the reproducibility of the Berger (two-dimensional CT) ...
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The Warwick Experience of the Oncotype DX® Breast Recurrence Score® Assay as a Predictor of Chemotherapy Administration.Breast Care Pub Date : 2018-07-13 ,DOI:10.1159/000489131Mashuk Alam Khan,Laura Henderson,Dayalan Clarke,Simon Harries,Lucie JonesThe Warwick Breast Unit, Warwick Hospital, Warwick, UK.
INTRODUCTION Oncotype DX® analyses the expression of 21 genes within tumour tissue to determine a Recurrence Score® (RS). RS is a marker of risk for distant recurrence in oestrogen receptor-positive early breast cancer, allowing patient-specific benefit of chemotherapy to be evaluated. Our aim was to determine whether the introduction of Oncotype DX led to a net reduction in chemotherapy use. METHODS
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Thermal stability of dialkylimidazolium tetrafluoroborate and hexafluorophosphate ionic liquids: ex situ bulk heating to complement in situ mass spectrometry†Physical Chemistry Chemical Physics (IF 3.945) Pub Date : 2018-06-01 ,DOI:10.1039/c8cp01090kCoby J. Clarke,Simon Puttick,Thomas J. Sanderson,Alasdair W. Taylor,Richard A. Bourne,Kevin R. J. Lovelock,Peter Licence
Thermal decomposition (TD) products of the ionic liquids (ILs) [CnC1Im][BF4] and [CnC1Im][PF6] ([CnC1Im]+ = 1-alkyl-3-methylimidazolium, [BF4]− = tetrafluoroborate, and [PF6]− = hexafluorophosphate) were prepared, ex situ, by bulk heating experiments in a bespoke setup. The respective products, CnC1(C3N2H2)BF3 and CnC1(C3N2H2)PF5 (1-alkyl-3-methylimidazolium-2-trifluoroborate and 1-alkyl-3-methyli
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Estimating success of vaginal birth after caesarean section in a regional Australian population: Validation of a prediction model.Australian and New Zealand Journal of Obstetrics and Gynaecology (IF 1.884) Pub Date : 2018-04-20 ,DOI:10.1111/ajo.12809Samantha S Mooney,Richard Hiscock,Inkeri D'Arcy Clarke,Simon CraigBACKGROUND Following a primary caesarean section (CS), women must decide between attempted vaginal birth after caesarean (VBAC) and elective repeat caesarean section (ERCS) in subsequent pregnancies. Both options carry potential morbidity and mortality for mother and child, with the most feared being uterine rupture and its consequences. In attempts to reduce morbidity, several predictive nomograms ...
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