- 作 者: ( "fuling zhou" OR "fu-ling zhou" )
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CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesisbioRxiv - Cancer Biology Pub Date : 2023-05-24 ,DOI:10.1101/2023.05.24.542034Muhammad Jamal, Yufei Lei, Hengjing He, Xingruo Zeng, Zimeng Wei, Di Xiao, Liang Shao, Fuling Zhou, Quiping Zhang
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy of the lymphoid progenitor cells contributing to ∼ 20% of the total ALL cases with higher prevalence in adults than the children. Despite the important role of human T-ALL cell lines in understanding the biology and treatment options, a detailed comparison of the tumorigenic potential of two commonly used T-ALL cell
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Risk factors and prognosis of thrombocytopenia in people living with HIV/AIDS.Therapeutic Advances in Hematology (IF 5.4) Pub Date : 2023-05-19 ,DOI:10.1177/20406207231170513Xiaoyan Lv,Pengpeng Li,Pengpeng Yue,Ping Tang,Fuling Zhou
Background Thrombocytopenia is a common hematological manifestation in people living with human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS; PLWHA). Data on the prognostic relationship and associated factors of thrombocytopenia and HIV infection in China are limited. Objectives We assessed the prevalence of thrombocytopenia, its association with prognosis, and analyzed
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Global burden of hematologic malignancies and evolution patterns over the past 30 yearsBlood Cancer Journal (IF 9.812) Pub Date : 2023-05-17 ,DOI:10.1038/s41408-023-00853-3Nan Zhang, Jinxian Wu, Qian Wang, Yuxing Liang, Xinqi Li, Guopeng Chen, Linlu Ma, Xiaoyan Liu, Fuling Zhou
Hematologic malignancies are among the most common cancers, and understanding their incidence and death is crucial for targeting prevention, clinical practice improvement, and research resources appropriately. Here, we investigated detailed information on hematological malignancies for the period 1990–2019 from the Global Burden of Disease study. The age-standardized incidence rate (ASIR), the age-standardized
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Optical time-stretch imaging flow cytometry in the compressed domainJournal of Biophotonics (IF 3.39) Pub Date : 2023-05-11 ,DOI:10.1002/jbio.202300096Siyuan Lin, Rubing Li, Yueyun Weng, Liye Mei, Chao Wei, Congkuan Song, Shubin Wei, Yifan Yao, Xiaolan Ruan, Fuling Zhou, Qing Geng, Du Wang, Cheng LeiImaging flow cytometry based on optical time-stretch (OTS) imaging combined with a microfluidic chip attracts much attention in the large-scale single-cell analysis due to its high throughput, high precision, and label-free operation. Compressive sensing has been integrated into OTS imaging to relieve the pressure on the sampling and transmission of massive data. However, image decompression brings ...
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Comprehensive analysis of clinical prognostic features and tumor microenvironment landscape of CD11b+CD64+ patients with acute myeloid leukemiaCellular Oncology (IF 7.051) Pub Date : 2023-04-18 ,DOI:10.1007/s13402-023-00808-7Qian Wang, Nan Zhang, Li Liu, Linlu Ma, Yuxin Tan, Xiaoyan Liu, Jinxian Wu, Guopeng Chen, Xinqi Li, Yuxing Liang, Fuling ZhouBackground Immunophenotyping surface molecules detected in the clinic are mainly applied in diagnostic confirmation and subtyping. However, the immunomodulatory molecules CD11b and CD64, are highly associated with leukemogenesis. Hence, the prognostic value of them and their potential biological functions merit further investigation. Methods Flow cytometry was operated to detect immunophenotypic molecules ...
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Integrated bioinformatic analysis of mitochondrial metabolism-related genes in acute myeloid leukemiaFrontiers in Immunology (IF 8.786) Pub Date : 2023-04-17 ,DOI:10.3389/fimmu.2023.1120670Xiqin Tong, Fuling Zhou
BackgroundAcute myeloid leukemia (AML) is a common hematologic malignancy characterized by poor prognoses and high recurrence rates. Mitochondrial metabolism has been increasingly recognized to be crucial in tumor progression and treatment resistance. The purpose of this study was to examined the role of mitochondrial metabolism in the immune regulation and prognosis of AML.MethodsIn this study, mutation
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Advances in CRISPR/Cas gene therapy for inborn errors of immunityFrontiers in Immunology (IF 8.786) Pub Date : 2023-03-27 ,DOI:10.3389/fimmu.2023.1111777Xinyi Liu, Guanglei Li, Yin Liu, Fuling Zhou, Xingxu Huang, Kui Li
Inborn errors of immunity (IEIs) are a group of inherited disorders caused by mutations in the protein-coding genes involved in innate and/or adaptive immunity. Hematopoietic stem cell transplantation (HSCT) is a mainstay definitive therapy for many severe IEIs. However, the lack of HLA-matched donors increases the risk of developing severe immunological complications. Gene therapy provides long-term
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Heterogeneous tissue construction by on-demand bubble-assisted acoustic patterningLab on a Chip (IF 7.517) Pub Date : 2023-03-27 ,DOI:10.1039/d3lc00122aQinghao Hu, Xuejia Hu, Yang Shi, Li Liang, Jiaomeng Zhu, Shukun Zhao, Yifan Wang, Zezheng Wu, Fubing Wang, Fuling Zhou, Yi YangHighly heterogeneous structures are closely related to the realization of the tissue functions of living organisms. However, precisely controlling the assembly of heterogeneous structures is still a crucial challenge. This work presents an on-demand bubble-assisted acoustic method for active cell patterning to achieve high-precision heterogeneous structures. Active cell patterning is achieved by the ...
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Cell damage evaluation by intelligent imaging flow cytometryCytometry Part A (IF 4.714) Pub Date : 2023-03-26 ,DOI:10.1002/cyto.a.24731Yifan Yao, Li He, Liye Mei, Yueyun Weng, Jin Huang, Shubin Wei, Rubing Li, Sheng Tian, Pan Liu, Xiaolan Ruan, Du Wang, Fuling Zhou, Cheng LeiEssential thrombocythemia (ET) is an uncommon situation in which the body produces too many platelets. This can cause blood clots anywhere in the body and results in various symptoms and even strokes or heart attacks. Removing excessive platelets using acoustofluidic methods receives extensive attention due to their high efficiency and high yield. While the damage to the remaining cells, such as erythrocytes ...
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Magnetically Actuated Hydrogel Stamping-Assisted Cellular Mechanical Analyzer for Stored Blood Quality DetectionACS Sensors (IF 9.618) Pub Date : 2023-03-03 ,DOI:10.1021/acssensors.2c02507Le Yu, Longfei Chen, Yantong Liu, Jiaomeng Zhu, Fang Wang, Linlu Ma, Kezhen Yi, Hui Xiao, Fuling Zhou, Fubing Wang, Long Bai, Yimin Zhu, Xuan Xiao, Yi YangCellular mechanical property analysis reflecting the physiological and pathological states of cells plays a crucial role in assessing the quality of stored blood. However, its complex equipment needs, operation difficulty, and clogging issues hinder automated and rapid biomechanical testing. Here, we propose a promising biosensor assisted by magnetically actuated hydrogel stamping to fulfill it. The ...
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All-Optical Fourier-Domain-Compressed Time-Stretch Imaging with Low-Pass FilteringACS Photonics (IF 7.077) Pub Date : 2023-02-17 ,DOI:10.1021/acsphotonics.2c01708Rubing Li, Yueyun Weng, Siyuan Lin, Chao Wei, Liye Mei, Shubin Wei, Yifan Yao, Fuling Zhou, Du Wang, Keisuke Goda, Cheng LeiOptical time-stretch (OTS) imaging has shown significant advantages in many applications, such as high-throughput cell screening, for its high frame rate and the capability of continuous image acquisition. Unfortunately, its application in practice is fundamentally limited by the pressure on data transmission and storage caused by the extreme throughput. Compressed sensing (CS) has been considered ...
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Typing of acute leukemia by intelligent optical time-stretch imaging flow cytometry on a chipLab on a Chip (IF 7.517) Pub Date : 2023-02-09 ,DOI:10.1039/d2lc01048hYueyun Weng, Hui Shen, Liye Mei, Li Liu, Yifan Yao, Rubing Li, Shubin Wei, Ruopeng Yan, Xiaolan Ruan, Du Wang, Yongchang Wei, Yunjie Deng, Yuqi Zhou, Tinghui Xiao, Keisuke Goda, Sheng Liu, Fuling Zhou, Cheng LeiAcute leukemia (AL) is one of the top life-threatening diseases. Accurate typing of AL can significantly improve its prognosis. However, conventional methods for AL typing often require cell staining, which is time-consuming and labor-intensive. Furthermore, their performance is highly limited by the specificity and availability of fluorescent labels, which can hardly meet the requirements of AL typing ...
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Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognitionNature Communications (IF 17.694) Pub Date : 2023-02-04 ,DOI:10.1038/s41467-023-36213-9Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F. Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun
Modular polyketide synthase (PKS) is an ingenious core machine that catalyzes abundant polyketides in nature. Exploring interactions among modules in PKS is very important for understanding the overall biosynthetic process and for engineering PKS assembly-lines. Here, we show that intermodular recognition between the enoylreductase domain ER1/2 inside module 1/2 and the ketosynthase domain KS3 inside
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LncRNA15691 promotes T-ALL infiltration by upregulating CCR9 via increased MATR3 stability.Journal of Leukocyte Biology (IF 6.011) Pub Date : 2023-02-01 ,DOI:10.1093/jleuko/qiac010Xingruo Zeng,Yufei Lei,Shan Pan,Jiaxing Sun,Hengjing He,Di Xiao,Muhammad Jamal,Hui Shen,Fuling Zhou,Liang Shao,Quiping Zhang
Our previous studies demonstrated that CCR9 plays an important role in several aspects of T-cell acute lymphoblastic leukemia progression and that CCR9 is a potential therapeutic target. However, the underlying mechanism that regulates CCR9 expression remains incompletely understood. In this study, bioinformatics analysis and validation in clinical samples revealed the lncRNA15691 to be positively
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CAR T-Cell Immunotherapy Treating T-ALL: Challenges and Opportunities.Vaccines Pub Date : 2023-01-12 ,DOI:10.3390/vaccines11010165Anqi Ren,Xiqin Tong,Na Xu,Tongcun Zhang,Fuling Zhou,Haichuan Zhu
T-cell acute lymphoblastic leukemia (T-ALL), a form of T-cell malignancy, is a typically aggressive hematological malignancy with high rates of disease relapse and a poor prognosis. Current guidelines do not recommend any specific treatments for these patients, and only allogeneic stem cell transplant, which is associated with potential risks and toxicities, is a curative therapy. Recent clinical trials
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Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance.Cell stem cell Pub Date : 2022-12-26 ,DOI:10.1016/j.stem.2022.12.003Yilin Chen,Peipei Wang,Jin Hu,Tong Zhang,Chengli Guo,Jihua Chai,Jing Wang,Manman Cui,Kexin Gao,Weidong Liu,Shuxin Yao,Pengbo Lu,Ziyan Cao,Yanbing Zheng,Jiwei Chang,Zheming Liu,Qibin Song,Weiming Li,Fuling Zhou,Haojian ZhangN6-methyladenosine (m6A) is a common chemical modification for mammalian mRNA and exhibits high dynamics in various biological processes. However, dynamics of m6A RNA methylome during leukemogenesis remains unknown. Here, we delineate a comprehensive m6A landscape during acute myeloid leukemia (AML) development and identify PRMT6 as a key for maintaining AML stem cells. We observe an obvious change ...
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dSTORM-Based Single-Cell Protein Quantitative Analysis Can Effectively Evaluate the Degradation Ability of PROTACsChemBioChem (IF 3.461) Pub Date : 2022-12-23 ,DOI:10.1002/cbic.202200680Fuwei Yang, Yuxin Tan, Cheng Wu, Lilan Xin, Zhenli Huang, Haibing Zhou, Fuling ZhouDetecting density dynamics: By using innovative single-color and two-color direct stochastic optical reconstruction microscopy, we have developed a simple and visual method that could analyze dynamic density changes in proteins of interest after treatment with PROTACs, at the single-cell level and in a fully quantitative degree. This method will be useful in screening PROTACs and accelerating the development ...
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Risk and prognosis of secondary breast cancer after radiation therapy for non-Hodgkin lymphoma: a massive population-based analysisClinical and Translational Oncology (IF 3.34) Pub Date : 2022-12-07 ,DOI:10.1007/s12094-022-03026-zXiaoyan Lv, Pengpeng Yue, Fuling ZhouPurpose One of the best ways to control non-Hodgkin lymphoma (NHL) locally is radiation therapy (RT), which is a crucial component of care for many patients. There has not been any research on the risk and prognosis of secondary breast cancer (SBC) in females with NHL receiving RT. Methods In our study, females with NHL as their initial cancer diagnosis were included from 1975 to 2018 in the Surveillance ...
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Indolent T-cell lymphoproliferative disorder of gastrointestinal tract with unusual clinical courses: report of 6 cases and literature reviewVirchows Archiv (IF 4.535) Pub Date : 2022-12-06 ,DOI:10.1007/s00428-022-03467-5Wei Fan, Li Niu, Huihua He, Jingping Yuan, Fei Yuan, Xueying Shi, Ye Wang, Min Chen, Meifang Huang, Fuling Zhou, Jian Xu, Qiongrong ChenIndolent T-cell lymphoproliferative disorder of the gastrointestinal tract (iTLPD-GI) is a rare neoplasm usually having an indolent clinical course and easily misdiagnosed as inflammatory bowel disease or other T-cell lymphomas. A subset of the disorders that progressed to overt peripheral T-cell lymphoma have been reported, and the etiology and pathogenesis are poorly understood. The current study ...
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High-throughput and high-accuracy diagnosis of multiple myeloma with multi-object detectionBiomedical Optics Express (IF 3.562) Pub Date : 2022-11-23 ,DOI:10.1364/boe.475166Liye Mei, Hui Shen, Yalan Yu, Yueyun Weng, Xiaoxiao Li, Kashif Rafiq Zahid, Jin Huang, Du Wang, Sheng Liu, Fuling Zhou, and Cheng Lei
Multiple myeloma (MM) is a type of blood cancer where plasma cells abnormally multiply and crowd out regular blood cells in the bones. Automated analysis of bone marrow smear examination is considered promising to improve the performance and reduce the labor cost in MM diagnosis. To address the drawbacks in established methods, which mainly aim at identifying monoclonal plasma cells (monoclonal PCs)
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Robust identification of extrachromosomal DNA and genetic variants using multiple genetic abnormality sequencing (MGA-Seq)bioRxiv - Genomics Pub Date : 2022-11-20 ,DOI:10.1101/2022.11.18.517160Da Lin, Yanyan Zou, Jinyue Wang, Qin Xiao, Fei Lin, Ningyuan Zhang, Zhaowei Teng, Shiyi Li, Yongchang Wei, Fuling Zhou, Rong Yin, Siheng Zhang, Chengchao Wu, Jing Zhang, Sheng Hu, Shuang Dong, Xiaoyu Li, Shengwei Ye, Haixiang Sun, Gang Cao
Genomic abnormalities, including structural variation (SV), copy number variation (CNV), single-nucleotide polymorphism (SNP), homogenously staining regions (HSR) and extrachromosomal DNA (ecDNA), are strongly associated with cancer, rare diseases and infertility. A robust technology to simultaneously detect these genomic abnormalities is highly desired for clinical diagnosis and basic research. In
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Serum proteomics screening intercellular adhesion molecule-2 improves intermediate-risk stratification in acute myeloid leukemiaTherapeutic Advances in Hematology (IF 5.4) Pub Date : 2022-10-28 ,DOI:10.1177/20406207221132346Nan Zhang, Xiaoyan Liu, Jinxian Wu, Xinqi Li, Qian Wang, Guopeng Chen, Linlu Ma, Sanyun Wu, Fuling Zhou
Background:The clinical risk classification of acute myelocytic leukemia (AML) is largely based on cytogenetic and molecular genetic detection. However, the optimal treatment for intermediate-risk ...
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Space-time-regulated imaging analyzer for smart coagulation diagnosisCell Reports Medicine (IF 16.988) Pub Date : 2022-10-06 ,DOI:10.1016/j.xcrm.2022.100765Longfei Chen, Le Yu, Yantong Liu, Hongshan Xu, Linlu Ma, Pengfu Tian, Jiaomeng Zhu, Fang Wang, Kezhen Yi, Hui Xiao, Fuling Zhou, Yi Yang, Yanxiang Cheng, Long Bai, Fubing Wang, Yimin Zhu
The development of intelligent blood coagulation diagnoses is awaited to meet the current need for large clinical time-sensitive caseloads due to its efficient and automated diagnoses. Herein, a method is reported and validated to realize it through artificial intelligence (AI)-assisted optical clotting biophysics (OCB) properties identification. The image differential calculation is used for precise
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A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemiaJournal of Cancer Research and Clinical Oncology (IF 4.322) Pub Date : 2022-09-03 ,DOI:10.1007/s00432-022-04333-2Guopeng Chen, Wenyan She, Chaochao Yu, Tuerxunayi Rouzi, Xinqi Li, Linlu Ma, Nan Zhang, Hongqiang Jiang, Xiaoyan Liu, Jinxian Wu, Qian Wang, Hui Shen, Fuling ZhouPurpose Acute myeloid leukemia (AML) is one of the most common neoplasms in adults, and it is difficult to achieve satisfactory results with conventional drugs. Here, we synthesized a novel organic arsenic derivative MZ2 and evaluated its ability to remodel energy metabolism to achieve anti-leukemia. Methods MZ2 was characterized by the average 1-min full mass spectra analysis. Biological methods such ...
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Extracellular Volume Fraction Based on Cardiac Magnetic Resonance T1 Mapping: An Effective Way to Evaluate Cardiac Injury Caused by Cardiac Amyloidosis in Patients with Multiple MyelomaJournal of Immunology Research (IF 4.493) Pub Date : 2022-08-13 ,DOI:10.1155/2022/3094933Minghui Liu, Liang Shao, Zhaoxia Yang, Qian Wang, Balu Wu, Xiaoyan Liu, Yalan Yu, Tingting Huang, Meixing Wang, Yong He, Guohong Liu, Fuling Zhou
Multiple myeloma (MM) is a hematological malignancy of plasma cell origin. Cardiac amyloidosis (CA) is a common form of heart damage caused by MM and is associated with a poor prognosis. This study was a prospective cohort study and was aimed at evaluating the clinical predictive value of extracellular volume fraction (ECV) based on cardiovascular magnetic resonance (CMR) T1 mapping for cardiac amyloidosis
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RNA m6A modification: Mapping methods, roles, and mechanisms in acute myeloid leukemia.Blood Science Pub Date : 2022-07-20 ,DOI:10.1097/bs9.0000000000000131Rong Yin,Yashu Li,Wen Tian,Fuling Zhou,Haojian Zhang
N6-Methyladenosine (m6A) is the most abundant modification in eukaryotic mRNA, and plays important biological functions via regulating RNA fate determination. Recent studies have shown that m6A modification plays a key role in hematologic malignancies, including acute myeloid leukemia. The current growth of epitranscriptomic research mainly benefits from technological progress in detecting RNA m6A
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Analysis of Risk Factors of Coagulation Dysfunction and Hemorrhage in Newly Diagnosed Hyperleukocytic Acute Myeloma LeukemiaContrast Media & Molecular Imaging (IF 3.009) Pub Date : 2022-07-13 ,DOI:10.1155/2022/7828230Anjie Xu, Pan Liu, Fuling Zhou
Purpose. To explore whether and why abnormal coagulation function and hemorrhage can appear in patients with hyperleukocytic acute myeloid leukemia (HAML). Method. We retrospectively reviewed the charts of 724 acute myeloid leukemia (AML) patients admitted with a white blood cell count of >100 × 109/L between 2010 and 2019 in order to analyze the coagulation index of patients with HAML and explore
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BM-Net: CNN-Based MobileNet-V3 and Bilinear Structure for Breast Cancer Detection in Whole Slide ImagesBioengineering Pub Date : 2022-06-20 ,DOI:10.3390/bioengineering9060261Jin Huang, Liye Mei, Mengping Long, Yiqiang Liu, Wei Sun, Xiaoxiao Li, Hui Shen, Fuling Zhou, Xiaolan Ruan, Du Wang, Shu Wang, Taobo Hu, Cheng Lei
Breast cancer is one of the most common types of cancer and is the leading cause of cancer-related death. Diagnosis of breast cancer is based on the evaluation of pathology slides. In the era of digital pathology, these slides can be converted into digital whole slide images (WSIs) for further analysis. However, due to their sheer size, digital WSIs diagnoses are time consuming and challenging. In
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Cardiac-Related Lesions in Newly Diagnosed Patients With Acute Leukemia: A Chinese Population-Based Real-World Study.Frontiers in Medicine (IF 5.058) Pub Date : 2022-06-09 ,DOI:10.3389/fmed.2022.844350Wei Xiao,Linlu Ma,Yufeng Shang,Fuwei Yang,Yuxin Tan,Guopeng Chen,Jinxian Wu,Yuxing Liang,Tuerxunayi Rouzi,Qian Wang,Nan Zhang,Fuling Zhou
The relationship between newly diagnosed acute leukemia (AL) and heart-related lesions remains unclear. This study aimed to investigate baseline cardiac function and risk of cardiovascular diseases (CVDs) in patients with new-onset AL, and provide data on cardiac management strategies for patients with AL. We retrospectively collected data on baseline characteristics, echocardiography, and biochemical
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Retraction Notice to: H3K27 demethylase KDM6B aggravates ischemic brain injury through demethylation of IRF4 and Notch2-dependent SOX9 activationMolecular Therapy - Nucleic Acids (IF 10.183) Pub Date : 2022-05-04 ,DOI:10.1016/j.omtn.2022.04.022Lisha Chang, Zhaowang An, Jiang Zhang, Fuling Zhou, Dali Wang, Jian Liu, Yunhe Zhang
Abstract not available
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