- 作 者: ( "dongqing li" OR "dong-qing li" )
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TIAM1 acts as an actin organization regulator to control adipose-derived pericyte cell fate.JCI Insight (IF 9.484) Pub Date : 2023-05-23 ,DOI:10.1172/jci.insight.159141Ginny Ching-Yun Hsu,Yiyun Wang,Amy Z Lu,Mario A Gomez-Salazar,Jiajia Xu,Dongqing Li,Carolyn Meyers,Stefano Negri,Sintawat Wangsiricharoen,Kristen P Broderick,Bruno Peault,Carol D Morris,Aaron W James
Pericytes are multipotent mesenchymal precursor cells that demonstrate tissue-specific properties. In this study, by comparing human adipose and periosteal-derived pericyte microarrays, we identified TIAM1 as a key regulator of cell morphology and differentiation decisions. TIAM1 represents a tissue-specific determinant between predispositions for adipocytic versus osteoblastic differentiation in human
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GPU-HADVPPM V1.0: high-efficient parallel GPU design of the Piecewise Parabolic Method (PPM) for horizontal advection in air quality model (CAMx V6.10)Geoscientific Model Development Pub Date : 2023-04-04 ,DOI:10.5194/egusphere-2023-410Kai Cao, Qizhong Wu, Lingling Wang, Nan Wang, Huaqiong Cheng, Xiao Tang, Dongqing Li, Lanning Wang
Abstract. With semiconductor technology gradually approaching its physical and thermal limits, Graphics processing unit (GPU) is becoming an attractive solution in many scientific applications due to their high performance. This paper presents an application of GPU accelerators in air quality model. We endeavor to demonstrate an approach that runs a PPM solver of horizontal advection (HADVPPM) for
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Synergistic ferroptosis-starvation therapy for bladder cancer based on hyaluronic acid modified metal–organic frameworksBioengineering & Translational Medicine (IF 10.684) Pub Date : 2023-03-22 ,DOI:10.1002/btm2.10515Yu Wang, Kunfeng Xie, Wei Chen, Yunze Fang, Qixin Mo, Henghui Zhang, Xinlei Zhao, Dongqing Li, Wanlong Tan, Peng Zhao, Fei Li
Bladder cancer (BCa) is one of the most common malignancies of the urinary tract. Metastasis and recurrence of BCa are the leading causes of poor prognosis, and only a few patients can benefit from current first-line treatments such as chemotherapy and immunotherapy. It is urgent to develop more effective therapeutic method with low side effects. Here, a cascade nanoreactor, ZIF-8/PdCuAu/GOx@HA (ZPG@H)
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High-Performance Integrated Iontronic Circuits Based on Single Nano/MicrochannelsSmall (IF 15.153) Pub Date : 2023-03-03 ,DOI:10.1002/smll.202208079Jun Li, Mengqi Li, Kaiping Zhang, Lide Hu, Dongqing LiRecently, artificial channel-based ionic diodes and transistors are extensively studied to mimic biological systems. Most of them are constructed vertically and are challenging to be further integrated. Several examples of ionic circuits with horizontal ionic diodes are reported. However, they generally require nanoscale channel sizes to meet the demand for ion-selectivity, resulting in low current ...
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Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transportCell Death and Differentiation (IF 12.067) Pub Date : 2023-03-03 ,DOI:10.1038/s41418-023-01142-zLetian Zhang, Minna Piipponen, Zhuang Liu, Dongqing Li, Xiaowei Bian, Guanglin Niu, Jennifer Geara, Maria A. Toma, Pehr Sommar, Ning Xu Landén
After a skin injury, keratinocytes switch from a state of homeostasis to one of regeneration leading to the reconstruction of the epidermal barrier. The regulatory mechanism of gene expression underpinning this key switch during human skin wound healing is enigmatic. Long noncoding RNAs (lncRNAs) constitute a new horizon in the understanding of the regulatory programs encoded in the mammalian genome
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Joint Transfer Extreme Learning Machine with Cross-Domain Mean Approximation and Output Weight AlignmentComplexity (IF 2.121) Pub Date : 2023-3-1 ,DOI:10.1155/2023/5072247Shaofei Zang, Dongqing Li, Chao Ma, Jianwei Ma
With fast learning speed and high accuracy, extreme learning machine (ELM) has achieved great success in pattern recognition and machine learning. Unfortunately, it will fail in the circumstance where plenty of labeled samples for training model are insufficient. The labeled samples are difficult to obtain due to their high cost. In this paper, we solve this problem with transfer learning and propose
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Effects of pore fluids on the hardening of shear modulus in tight dolomite: experimental observations and theoretical modelingGeophysical Journal International (IF 3.352) Pub Date : 2023-02-23 ,DOI:10.1093/gji/ggad085Dongqing Li, Jianxin WeiSummary Understanding the influence of pore fluids on acoustic characteristics of rocks containing pores of low aspect ratio, i.e. cracks is crucial for both laboratory and field observations of seismic exploration. Unlike the petrophysical aspects of conventional rock species, those of tight dolomites are relatively more complex and poorly understood. To address this problem, we investigated the ultrasonic ...
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Angiotensin receptor-neprilysin inhibitor delays progression from paroxysmal to persistent atrial fibrillationScientific Reports (IF 4.996) Pub Date : 2023-02-23 ,DOI:10.1038/s41598-023-30349-wYouzheng Dong, Zhenyu Zhai, Jihong Wang, Zhen Xia, Zirong Xia, Bo Zhu, Quanbing Dong, Qing Li, Juxiang Li
Progression from paroxysmal to persistent atrial fibrillation (AF) is linked to adverse clinical outcomes. The present study sought to clarify whether angiotensin receptor-neprilysin inhibitor (ARNI) can delay AF progression. A retrospective cohort study was conducted on consecutive patients with paroxysmal AF admitted at the Second Affiliated Hospital of Nanchang University between January 2017 and
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Dyadic effects of work overcommitment on depression in dual-earner couples: based on the actor–partner interdependence modelPsychology, Health & Medicine (IF 3.898) Pub Date : 2023-02-13 ,DOI:10.1080/13548506.2023.2177685Jinfeng Zhang, Dongqing LiABSTRACT In this study, we aimed to examine the actor and partner effects of overcommitment on depression in dual-earner couples and the potential mediating role of emotional exhaustion at the actor and partner levels. With a cross-sectional design, 172 dual-earner couples in Chongqing, China, completed the measures of overcommitment, emotional exhaustion, and depression. The results showed that (a) ...
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Local Buckling-Induced Forming Method to Produce Metal BellowsChinese Journal of Mechanical Engineering (IF 1.824) Pub Date : 2023-02-10 ,DOI:10.1186/s10033-023-00852-2Tianyin Zhang, Dongqing Li, Tianjiao Xu, Yongfeng Sui, Xianhong Han
A novel buckling-induced forming method is proposed to produce metal bellows. The tube billet is firstly treated by local heating and cooling, and the axial loading is applied on both ends of the tube, then the buckling occurs at the designated position and forms a convolution. In this paper, a forming apparatus is designed and developed to produce both discontinuous and continuous bellows of 304 stainless
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Regulation of cisplatin resistance in bladder cancer by epigenetic mechanismsDrug Resistance Updates (IF 22.841) Pub Date : 2023-02-09 ,DOI:10.1016/j.drup.2023.100938Fei Li, Zaosong Zheng, Wei Chen, Dongqing Li, Henghui Zhang, Yuanchao Zhu, Qixin Mo, Xinlei Zhao, Qin Fan, Fan Deng, Conghui Han, Wanlong TanBladder cancer is one of the most common malignancies in the world. Cisplatin is one of the most potent and widely used anticancer drugs and has been employed in several malignancies. Cisplatin-based combination chemotherapies have become important adjuvant therapies for bladder cancer patients. Cisplatin-based treatment often results in the development of chemoresistance, leading to therapeutic failure ...
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The influence of anthropogenic emissions on air quality in Beijing-Tianjin-Hebei of China around 2050 under the future climate scenarioJournal of Cleaner Production (IF 11.072) Pub Date : 2023-01-05 ,DOI:10.1016/j.jclepro.2023.135927Dongqing Li, Qizhong Wu, Jinming Feng, Yongli Wang, Lanning Wang, Qi Xu, Yiming Sun, Kai Cao, Huaqiong ChengThe Beijing-Tianjin-Hebei (BTH) region of China is one of the most frequently referenced areas with PM2.5 air pollution and various control measures; hence, it is critical to project the future air quality on this region under different emission scenarios. In this study, using a global climate model, regional meteorological model, emission process model and air quality model, a future air quality research ...
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The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered regionCell Reports (IF 9.995) Pub Date : 2022-12-28 ,DOI:10.1016/j.celrep.2022.111916Guanlan Fan, Fan Wang, Yurou Chen, Qian Zheng, Jie Xiong, Qiongying Lv, Kejia Wu, Jiaqiang Xiong, Lei Wei, Dongqing Li, Jiachen Zhang, Wei Zhang, Feng LiAkt is commonly activated and serves as a valuable target in human cancer. In this study, OTUD1 is identified as an Akt-associated protein and is downregulated upon Akt activation. Ectopic OTUD1 inhibits Akt phosphorylation; however, its deubiquitinase activity contributes only slightly to this effect. A short peptide (OUN-36) located in the OTUD1 N-terminal intrinsically disordered region strongly ...
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Fabricating a PDMS optical lens with the interaction of a negatively-charged air-resin interface and an electric fieldColloids and Surfaces A: Physicochemical and Engineering Aspects (IF 5.518) Pub Date : 2022-12-24 ,DOI:10.1016/j.colsurfa.2022.130876Pu Liu, Xiangyu Zhang, Quanyu Wang, Ming Zhao, Yongxin Song, Dongqing LiIn this paper, a technique for the fabrication of a PDMS optical lens with the aid of a high electric field was introduced. The lens was fabricated by casting liquid PDMS onto a concave resin master formed under the repulsion between the negatively charged air-resin interface and the overhead high electric field. The focal length and surface profile of the lens under different electric fields were ...
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pH-Regulated Ionic Diode Based on an Asymmetric Shaped Multiple-Layer Polymer MembraneAnalytical Chemistry (IF 8.008) Pub Date : 2022-12-19 ,DOI:10.1021/acs.analchem.2c04369Jun Li, Kaiping Zhang, Dongqing LiSmart artificial ion channels with tunable properties have wide applications in many fields to achieve ion transport manipulation. Most reported artificial ions are constructed with vertical structures, limiting the further integration of ionic diodes into complex iontronic systems. Inspired by the asymmetric concentration polarization induced by the asymmetric geometry of nanochannels, a novel method ...
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Comparison of the Chemical Components, Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum Flower against Liver-Fire Hyperactivity Syndrome of Hypertension via Integrative AnalysesInternational Journal of Molecular Sciences (IF 4.556) Pub Date : 2022-11-09 ,DOI:10.3390/ijms232213767Yue Wang, Yangyu Li, Wei Guo, Xiao Yang, Jiameng Qu, Mang Gao, Shuting Chen, Jiangru Dong, Qing Li, Tiejie Wang
To clarify the differences in the clinical application scope of Chrysanthemum morifolium flower (CMF) and Chrysanthemum indicum flower (CIF), two herbs of similar origin, an integrated strategy of network pharmacology, molecular pharmacology, and metabolomics was employed, with a view to investigating the commonalities and dissimilarities in chemical components, efficacy and mechanisms of action. Initial
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Deficiency of miR-29a/b1 leads to premature aging and dopaminergic neuroprotection in miceFrontiers in Molecular Neuroscience (IF 6.261) Pub Date : 2022-10-06 ,DOI:10.3389/fnmol.2022.978191Xiaochen Bai, Jinghui Wang, Xiaoshuang Zhang, Yilin Tang, Yongtao He, Jiayin Zhao, Linlin Han, Rong Fang, Zhaolin Liu, Hongtian Dong, Qing Li, Jingyu Ge, Yuanyuan Ma, Mei Yu, Ruilin Sun, Jian Wang, Jian Fei, Fang Huang
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive degeneration of midbrain dopaminergic neurons. The miR-29s family, including miR-29a and miR-29b1 as well as miR-29b2 and miR-29c, are implicated in aging, metabolism, neuronal survival, and neurological disorders. In this study, the roles of miR-29a/b1 in aging and PD were investigated. miR-29a/b1 knockout mice (named
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Towards Age-Optimal Transmission in Satellite-Integrated IoT: A Two-Layer Coding ApproachIEEE Transactions on Vehicular Technology (IF 6.239) Pub Date : 2022-09-12 ,DOI:10.1109/tvt.2022.3205625Dongqing Li, Shaohua Wu, Jian Jiao, Ning Zhang, Qinyu ZhangTo support the emergent freshness-critical applications in the satellite-integrated IoT, information must be transmitted timely and reliably. A significant limitation of the upcoming satellite-integrated IoT era is the non-trivial propagation latency because of long-distance communication. To realize timely information delivery, the hybrid automatic repeat request (HARQ) strategy with frequent feedback ...
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The injury-induced circular RNA circGLIS3 activates dermal fibroblasts to promote wound healingbioRxiv - Molecular Biology Pub Date : 2022-09-05 ,DOI:10.1101/2022.09.05.506337Maria A. Toma, Qizhang Wang, Dongqing Li, Yunting Xiao, Guanglin Niu, Jennifer Geara, Manika Vij, Minna Piipponen, Zhuang Liu, Letian Zhang, Xiaowei Bian, Aoxue Wang, Pehr Sommar, Ning Xu Landhén
Delayed skin wound healing and excessive scarring are consequences of an impaired healing process and represent a major health and economic burden worldwide. Current intervention strategies lack efficacy and suffer from high recurrence rates necessitating the investigation into alternative treatment modalities like circular RNAs (circRNAs). By RNA sequencing, we profiled circRNA expression changes
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Beyond the Code: Noncoding RNAs in Skin Wound HealingCold Spring Harbor Perspectives in Biology (IF 9.708) Pub Date : 2022-09-01 ,DOI:10.1101/cshperspect.a041230Dongqing Li, Guanglin Niu, Ning Xu LandénAn increasing number of noncoding RNAs (ncRNAs) have been found to regulate gene expression and protein functions, playing important roles in diverse biological processes and diseases. Their crucial functions have been reported in almost every cell type and all stages of skin wound healing. Evidence of their pathogenetic roles in common wound complications, such as chronic nonhealing wounds and excessive ...
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Louki Zupa decoction attenuates the airway inflammation in acute asthma mice induced by ovalbumin through IL-33/ST2-NF-κB/GSK3β/mTOR signalling pathwayPharmaceutical Biology (IF 3.889) Pub Date : 2022-08-11 ,DOI:10.1080/13880209.2022.2104327Xi Huang, Hang Yu, Cong Xie, Yao-Long Zhou, Meng-Meng Chen, Han-Lin Shi, Wei-Feng Tang, Jing-Cheng Dong, Qing-Li Luo
Abstract Context Asthma is a common respiratory system disease. Louki Zupa decoction (LKZP), a traditional Chinese medicine, presents a promising efficacy against lung diseases. Objective To investigate the pathogenic mechanism of asthma and reveal the intervention mechanism of LKZP. Materials and methods Forty-eight female Balb/c mice were randomly divided into 6 groups: normal control group (NC)
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Integrative small and long RNA omics analysis of human healing and nonhealing wounds discovers cooperating microRNAs as therapeutic targetseLife (IF 8.713) Pub Date : 2022-08-09 ,DOI:https://doi.org/10.7554/elife.80322Zhuang Liu, Letian Zhang, Maria A Toma, Dongqing Li, Xiaowei Bian, Irena Pastar, Marjana Tomic-Canic, Pehr Sommar, Ning Xu LandénMicroRNAs (miR), as important epigenetic control factors, reportedly regulate wound repair. However, our insufficient knowledge of clinically relevant miRs hinders their potential therapeutic use. For this, we performed paired small RNA and long RNA sequencing and integrative omics analysis in human tissue samples, including matched skin and acute wounds collected at each healing stage and chronic ...
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Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transportbioRxiv - Molecular Biology Pub Date : 2022-07-04 ,DOI:10.1101/2022.07.04.498689Letian Zhang, Minna Piipponen, Zhuang Liu, Dongqing Li, Xiaowei Bian, Maria A. Toma, Pehr Sommar, Ning Xu Landén
After a skin injury, keratinocytes switch from a state of homeostasis to one of regeneration leading to the reconstruction of the epidermal barrier. The regulatory mechanism of gene expression underpinning this key switch during human skin wound healing is enigmatic. Long noncoding RNAs (lncRNAs) constitute a new horizon in the understanding of the regulatory programmes encoded in the mammalian genome
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Living algae detection with a PDMS-liquid chlorophyll fluorescence microfluidic chip filter and a smartphoneAnalyst (IF 5.227) Pub Date : 2022-06-23 ,DOI:10.1039/d2an00375aJianhua Liu, Hui Chang, Xiangyu Zhang, Shimeng Chen, Yongxin Song, Dongqing LiBuilding an optical filtration function into a microfluidic chip is a promising way of simplifying the optical detection system of a microfluidic device. In this paper, a PDMS microfluidic chip filter that is capable of transmitting chlorophyll fluorescence and blocking interfering light in the visible wavelength range was developed for living algae detection with a smartphone. The chip was fabricated ...
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Interleukin-17 governs hypoxic adaptation of injured epitheliumScience (IF 63.714) Pub Date : 2022-06-16 ,DOI:10.1126/science.abg9302Piotr Konieczny, Yue Xing, Ikjot Sidhu, Ipsita Subudhi, Kody P. Mansfield, Brandon Hsieh, Douglas E. Biancur, Samantha B. Larsen, Michael Cammer, Dongqing Li, Ning Xu Landén, Cynthia Loomis, Adriana Heguy, Anastasia N. Tikhonova, Aristotelis Tsirigos, Shruti NaikMammalian cells autonomously activate hypoxia-inducible transcription factors to ensure survival in low-oxygen environments. We report that injury-induced hypoxia is insufficient to trigger hypoxia-inducible factor 1 alpha (HIF1α) in damaged epithelium. Instead, multimodal single-cell and spatial transcriptomics analyses and functional studies reveal that RORγt + γδ T cell–derived interleukin (IL)-17A ...
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A BIRC5High COD1Low Cancer Tissue Phenotype Indicates Poorer Prognosis of Metastatic Breast Cancer PatientsCancer Informatics Pub Date : 2022-06-14 ,DOI:10.1177/11769351221096655Yujie Bai, Feng Yuan, Jing Yu, Yibei Si, Yiwen Zheng, Dongqing Li
Extensive data research is helpful to find sensitive biomarkers for prognostic prediction of metastatic breast cancer. Through analyzing multiple GEO datasets, literature retrieval, and verified in...
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Single Artificial Ion Channels with Tunable Ion Transport Based on the Surface Modification of pH-Responsive PolymersACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2022-06-07 ,DOI:10.1021/acsami.2c03949Jun Li, Kaiping Zhang, Xiaoye Zhao, Dongqing LiArtificial ion channels with tunable ionic transport control and intelligent iontronic functions at the nanoscale have a wide application in logic computing and biosensing. Although some artificial ion channels with smart ion transport characteristics have been developed, most of them are constructed on porous membranes with undefined channel numbers. It is still challenging to achieve multiple ion ...
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Quantitative Evaluation Method of Structural Safety for the Great Wall Hollow Defensive Forts under Gravity LoadsInternational Journal of Architectural Heritage (IF 3.0) Pub Date : 2022-05-17 ,DOI:10.1080/15583058.2022.2070048Haoyu Wang, Qing Chun, Chengwen Zhang, Pan Li, Dongqing Li, Fei ZhaiABSTRACT The Great Wall is one of the most famous cultural heritages in the world. The defensive forts constitute the most important parts of the Great Wall. However, many of them have been severely damaged through the centuries, and their status requires a scientific evaluation. Taking the part of the Great Wall in the Yanqing district with 101 defensive forts as an example, on-site investigations ...
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Modification of silty clay subgrade filler with red Pisha sandstone and carbide slag in seasonally frozen regionsEnvironmental Earth Sciences (IF 3.119) Pub Date : 2022-05-04 ,DOI:10.1007/s12665-022-10381-1Yuhang Liu, Dongqing Li, Feng MingProper utilization of lower cost waste materials and industrial by-products for subgrade filling soil stabilization is an avenue of resource conservation and environmental protection. In this study, red Pisha sandstone (RPS) and carbide slag (CS) were selected to stabilize silty clay. The improvement effects of RPS–CS-stabilized soil with different admixture contents were evaluated through strength ...
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β-Glucan Combined With PD-1/PD-L1 Checkpoint Blockade for Immunotherapy in Patients With Advanced Cancer.Frontiers in Pharmacology (IF 5.988) Pub Date : 2022-04-25 ,DOI:10.3389/fphar.2022.887457Mengjie Wang,Yu Bai,Jiaxin Pei,Dongqing Li,Xiaolin Pu,Wenyu Zhu,Lei Xia,Chunjian Qi,Hua Jiang,Yongling Ning
Programmed death-1 (PD-1)/PD-ligand 1 (PD-L1) checkpoint blocking antibodies have been shown to be a powerful immune checkpoint blockade (ICB) therapy for patients with cancer. However, patients quickly develop resistance to immunotherapy. β-glucan, an immune adjuvant, has been found to stimulate innate and adaptive immune responses. In this study, we assessed the use of whole glucan particle (WGP)
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