- 作 者: "fang wang"
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Neutrophil extracellular traps contribute to coagulopathy after traumatic brain injuryJCI Insight (IF 9.484) Pub Date : 2023 ,DOI:10.1172/jci.insight.141110Jiaqi Jin, Fang Wang, Jiawei Tian, Xinyi Zhao, Jiawei Dong, Nan Wang, Zhihui Liu, Hongtao Zhao, Wenqiang Li, Ge Mang, Shaoshan Hu
Coagulopathy contributes to the majority of deaths and disabilities associated with traumatic brain injury (TBI). Whether neutrophil extracellular traps (NETs) contribute to an abnormal coagulation state in the acute phase of TBI remains unknown. Our objectives were to demonstrate the definitive role of NETs in coagulopathy in TBI. We detected NET markers in 128 TBI patients and 34 healthy individuals
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Recommendation of mHAP and ABCR scoring systems for the decision-making of the first and subsequent TACE session in HCC patientsEuropean Journal of Gastroenterology & Hepatology (IF 2.586) Pub Date : 2023-04-01 ,DOI:10.1097/meg.0000000000002515Kefeng Jia, Weili Yin, Zhongsong Gao, Wen Shen, Fang Wang, Shuangshuang Xie, Mingge Li, Rong LvBackground Due to the high heterogeneity among hepatocellular carcinoma (HCC) patients receiving transarterial chemoembolization (TACE), the prognosis of patients varies significantly. Various predictive scoring systems have been developed to identify the patients who could benefit from TACE. However, there is no consensus on which is better. This study aims to validate and compare the predictive ...
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Link prediction from fusion informationPhysica A: Statistical Mechanics and its Applications (IF 3.778) Pub Date : 2023-03-23 ,DOI:10.1016/j.physa.2023.128694Yang Jiao, Jianshe Wu, Peng Xiang, Fang WangLink prediction of complex network aims at predicting the likelihood of the existence of unknown links. In the most previous works, many kinds of information, such as common neighbor, local path, transition probability, have been used to predict the unknown links. However, methods using fusion information are relatively rare. In this paper, different kinds of information are fused with community information ...
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Mangcuo Lake in Hengduan Mountains: An Important Alpine Breeding and Stopover Site along Central Asian FlywayAnimals (IF 3.231) Pub Date : 2023-03-23 ,DOI:10.3390/ani13071139Fang Wang, Yongbing Yang, Gang Song, Xiaojuan Shi, Bu Pu, Le YangThe stopovers provide food and habitat for migratory birds and therefore play an important role in facilitating the birds’ completion of their migration. The Hengduan Mountains, which have a complex topography, are located in a large corridor of the Central Asian migratory flyway, so the lakes along the Hengduan Mountains are important for waterbird migration. The existing research on lakes in the ...
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Structural optimisation of transportation equipment using an adaptive approximation modelProceedings of the Institution of Civil Engineers - Transport (IF 1.121) Pub Date : 2023-03-23 ,DOI:10.1680/jtran.22.00100Xin Liu, Zhonghua Chen, Xiang Liu, Zhenhua Zhou, Qiqi Li, Fang WangConsidering the high computational cost of the optimisation process of complex transportation equipment, an efficient structural optimisation method for transportation equipment based on the multi-criteria sample updating and management strategy of the approximation model is proposed. First, the approximation models of the objective function and constraints are established based on the radial basis ...
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Genome assembly of the ectoparasitoid wasp Theocolax elegansScientific Data (IF 8.501) Pub Date : 2023-03-22 ,DOI:10.1038/s41597-023-02067-5Shan Xiao, Xinhai Ye, Shuping Wang, Yi Yang, Qi Fang, Fang Wang, Gongyin Ye
The ectoparasitoid wasp Theocolax elegans is a cosmopolitan and generalist pteromalid parasitoid of several major storage insect pests, and can effectively suppress a host population in warehouses. However, little molecular information about this wasp is currently available. In this study, we assembled the genome of T. elegans using PacBio long-read sequencing, Illumina sequencing, and Hi-C methods
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Wide-Bandgap Rare-Earth Iodate Single Crystals for Superior X-Ray Detection and ImagingAdvanced Science (IF 17.521) Pub Date : 2023-03-22 ,DOI:10.1002/advs.202206833Xieming Xu, Fang Wang, Weiwei Xu, Hao Lu, Lingfei Lv, Hongyuan Sha, Xiaoming Jiang, Shaofan Wu, Shuaihua WangSemiconductor-based X-ray detectors with low detectable thresholds become critical in medical radiography applications. However, their performance is generally limited by intrinsic defects or unresolved issues of materials, and developing a novel scintillation semiconductor for low-dose X-ray detection is a highly urgent objective. Herein, a high-quality rare-earth iodate Tm(IO3)3 single crystal grown ...
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The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesisCell Reports (IF 9.995) Pub Date : 2023-03-22 ,DOI:10.1016/j.celrep.2023.112288Hao Hu, Kailiang Zhao, Debao Fang, Zhongyu Wang, Ning Yu, Bo Yao, Kaiyue Liu, Fang Wang, Yide MeiThe tumor suppressor p53 plays a pivotal role in tumor prevention. The activity of p53 is mainly restrained by the ubiquitin E3 ligase Mdm2. However, it is not well understood how the Mdm2-p53 pathway is intricately regulated. Here we report that the RNA binding protein RALY functions as an oncogenic factor in lung cancer. RALY simultaneously binds to Mdm2 and the deubiquitinating enzyme USP7. Via ...
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Enhancing thermoelectric performance of n-type AgBi3S5 through synergistically optimizing the effective mass and carrier mobilityJournal of Materiomics (IF 8.589) Pub Date : 2023-03-22 ,DOI:10.1016/j.jmat.2023.02.010Xin Qian, Xiaoxue Zhang, Haoran Guo, Bangfu Ding, Mingjing Chen, Jiang-Long Wang, Li-Dong Zhao, Shu-Fang WangAgBi3S5 is a new n-type thermoelectric material that is environmentally friendly and composed of elements of earth-abundant, non-toxic and high performance-cost ratio. This compound features an intrinsically low thermal conductivity derived from its complex monoclinic structure. However, the terrible electrical transport properties greatly limited the improvement of thermoelectric performance. Most ...
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The ordered nanoporous CrFe alloy with rapid strain hardening abilityJournal of Materials Research and Technology (IF 6.267) Pub Date : 2023-03-21 ,DOI:10.1016/j.jmrt.2023.03.088Chaoyang Wang, Shengli Zhu, Yanqin Liang, Chunling Qin, Fang Wang, Hao Wang, Chuntao Chang, Akihisa InoueThe deformation behavior of nanoporous metal (NPM) is important for their wide range of applications. Strain hardening can effectively enhance the resistance to the deformation. Here we report a novel nanoporous CrFe alloy with ordered structure, which is fabricated by selective phase dissolution of the two-phase Al-Ni-Fe-Cr high entropy alloy. The formation mechanism, microstructure and deformation ...
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Polymorphisms of placental iodothyronine deiodinase genes in a rural area of Northern China with high prevalence of neural tube defectsHuman Heredity (IF 1.455) Pub Date : 2023-03-21 ,DOI:10.1159/000530112Fang Wang, Yan-Hong Gu, Jin Guo, YiHua Bao, ZhiYong Qiu, Ping Zheng, Masaru Ushijima, Masaaki Matsuura, Ting ZhangIntroduction: We have reported that high total homocysteine (tHCY), and the coexistence of inadequate thyroid hormones in maternal serum increase the risk of fetal neural tube defects (NTDs). Placental iodothyronine deiodinases (DIOs: DIO1, DIO2, and DIO3) play a role in regulate the conversions between different forms of maternal thyroid hormones. This study hypothesized that single nucleotide polymorphisms ...
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Atomistic study on crystal orientation-dependent crack propagation and resultant microstructure anisotropy in NiTi alloysInternational Journal of Mechanical Sciences (IF 6.772) Pub Date : 2023-03-20 ,DOI:10.1016/j.ijmecsci.2023.108320Guiqiu Xie, Fang Wang, Xin Lai, Zunping Xu, Xiangguo ZengThe primary objective of this study was to explore the crystal orientation-dependent fracture mechanism of nickel–titanium (NiTi) alloys by using molecular dynamics simulations. We discovered that the stress concentration ahead of the crack tip induced the formation of martensite with a herringbone twin or mixed HCP/OTHER atom morphology, while reverse martensite transformation occurred behind the ...
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Design, Synthesis, and Biological Evaluation of Sulfonamide Methoxypyridine Derivatives as Novel PI3K/mTOR Dual InhibitorsPharmaceuticals (IF 4.286) Pub Date : 2023-03-20 ,DOI:10.3390/ph16030461Haotian Gao, Zaolin Li, Kai Wang, Yuhan Zhang, Tong Wang, Fang Wang, Youjun XuPhosphatidylinositol 3-kinase (PI3K) plays an important role in cell proliferation, survival, migration, and metabolism, and has become an effective target for cancer treatment. Meanwhile, inhibiting both PI3K and mammalian rapamycin receptor (mTOR) can simultaneously improve the efficiency of anti-tumor therapy. Herein, a series of 36 sulfonamide methoxypyridine derivatives with three different aromatic ...
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Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosisNature Structural & Molecular Biology (IF 18.361) Pub Date : 2023-03-20 ,DOI:10.1038/s41594-023-00943-7Dounia Djeghloul, Andrew Dimond, Sherry Cheriyamkunnel, Holger Kramer, Bhavik Patel, Karen Brown, Alex Montoya, Chad Whilding, Yi-Fang Wang, Matthias E. Futschik, Nicolas Veland, Thomas Montavon, Thomas Jenuwein, Matthias Merkenschlager, Amanda G. FisherRecent studies have shown that repressive chromatin machinery, including DNA methyltransferases and polycomb repressor complexes, binds to chromosomes throughout mitosis and their depletion results in increased chromosome size. In the present study, we show that enzymes that catalyze H3K9 methylation, such as Suv39h1, Suv39h2, G9a and Glp, are also retained on mitotic chromosomes. Surprisingly, however ...
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Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunityCell Reports (IF 9.995) Pub Date : 2023-03-20 ,DOI:10.1016/j.celrep.2023.112275Haipeng Liu, Hang Su, Fei Wang, Yifang Dang, Yijiu Ren, Shenyi Yin, Huinan Lu, Hang Zhang, Jun Wu, Zhu Xu, Mengge Zheng, Jiani Gao, Yajuan Cao, Junfang Xu, Li Chen, Xiangyang Wu, Mingtong Ma, Long Xu, Fang Wang, Jianxia Chen, Chang ChenEnhancing chemosensitivity is one of the largest unmet medical needs in cancer therapy. Cyclic GMP-AMP synthase (cGAS) connects genome instability caused by platinum-based chemotherapeutics to type I interferon (IFN) response. Here, by using a high-throughput small-molecule microarray-based screening of cGAS interacting compounds, we identify brivanib, known as a dual inhibitor of vascular endothelial ...
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BAG3: Nature’s Quintessential Multi-Functional Protein Functions as a Ubiquitous Intra-Cellular GlueCells (IF 7.666) Pub Date : 2023-03-19 ,DOI:10.3390/cells12060937Caitlyn M. Brenner, Muaaz Choudhary, Michael G. McCormick, David Cheung, Gavin P. Landesberg, Ju-Fang Wang, Jianliang Song, Thomas G. Martin, Joseph Y. Cheung, Hui-Qi Qu, Hakon Hakonarson, Arthur M. FeldmanBAG3 is a 575 amino acid protein that is found throughout the animal kingdom and homologs have been identified in plants. The protein is expressed ubiquitously but is most prominent in cardiac muscle, skeletal muscle, the brain and in many cancers. We describe BAG3 as a quintessential multi-functional protein. It supports autophagy of both misfolded proteins and damaged organelles, inhibits apoptosis ...
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Effect of N Fertilizer Dosage and Base/Topdressing Ratio on Potato Growth Characteristics and YieldAgronomy (IF 3.949) Pub Date : 2023-03-18 ,DOI:10.3390/agronomy13030909Xiaoting Fang, Zhuqing Xiang , Haiyan Ma , Fang Wang, Qiang Wang , Peihua Li, Shunlin ZhengNitrogen fertilizer is an important kinetic energy for potato production. To study the effect of nitrogen(N) fertilizer application and the topdressing ratio on potato growth and yield, different N application levels: N75 (75 kg ha−1), N150 (150 kg ha−1), N225 (225 kg ha−1) and different N fertilizer base/topdressing ratios: T1 (2:8), T2 (5:5), T3 (8:2), and T4 (10:0) were used to find the best N fertilizer ...
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Advance intervention of recessive ill-conditioned feature: the early-stage design method based on system recessive inheritanceJournal of Engineering Design (IF 2.4) Pub Date : 2023-03-17 ,DOI:10.1080/09544828.2023.2180985Zifeng Nie, Peng Zhang, Fang WangIn the fusion design process of the system, ill-conditioned features, that are not explicit in previous generation systems, may exhibit to negate the operation of the new-generation system. This type of ill-conditioned feature is termed as the recessive ill-conditioned feature (R-ICF) of the system. It is believed that R-ICF in the fusion design process is attributed to the complex system recessive ...
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Singlet oxygen-dominated non-radical oxidation in biochar/peroxymonosulfate system for efficient degradation of tetracycline hydrochloride: Surface site and catalytic mechanismJournal of the Taiwan Institute of Chemical Engineers (IF 5.477) Pub Date : 2023-03-17 ,DOI:10.1016/j.jtice.2023.104815Rui Zhang, Zhi-Xia Zhang, Fang Wang, Dezhi ChenBackground Biochar has attracted much attention in peroxymonosulfate (PMS) activation for the elimination of organic pollutants in water. However, the factor to determine the catalytic efficiency of biochar and the evolution of reactive oxygen species (ROS) remain equivocal and elusive. Method & result In this study, Camellia oleifera shell-derived biochar (COSB) was prepared by one-step pyrolysis ...
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Effects of disorganization of retinal inner layers for Idiopathic epiretinal membrane surgery: the surgical status and prognosisBMC Ophthalmology (IF 2.086) Pub Date : 2023-03-17 ,DOI:10.1186/s12886-023-02856-xHuanhuan Li, Conghui Zhang, Hui Li, Shuai Yang, Yao Liu, Fang WangTo compare the surgical status in idiopathic epiretinal membrane (IERM) patients with or without disorganization of retinal inner layers (DRIL) and to correlate with optical coherence tomography angiography (OCTA) and clinical data. In 74 eyes from 74 patients with IERM treated by surgery with 12-month follow-up. According to the superficial hemorrhage, the patients were divided into group A (no macular ...
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HIF1A overexpression predicts the high lymph node metastasis risk and indicates a poor prognosis in papillary thyroid cancerHeliyon (IF 3.776) Pub Date : 2023-03-17 ,DOI:10.1016/j.heliyon.2023.e14714Yong-xun Zhao, Ze Yang, Li-bin Ma, Fang Wang, Yong Wang, Cheng XiangObjective To investigate the value of Hypoxia-inducible factor 1 A (HIF1A) in predicting lymph node metastasis (LNM) stage and clinical outcomes of papillary thyroid cancer (PTC) patients. Materials and methods The HIF1A gene expression analysis in PTC was performed by bioinformatics approaches followed by evaluating its protein level using immunohistochemistry analysis. The role of HIF1A in predicting ...
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Ecological introspection resulting from the COVID-19 pandemic: the threat perception of the pandemic was positively related to pro-environmental behaviorsThe Journal of Positive Psychology (IF 4.29) Pub Date : 2023-03-17 ,DOI:10.1080/17439760.2023.2190923Shijiang Zuo, Fang Wang, Ying-Yi Hong, Hoi-Wing Chan, Connie Pui-Yee Chiu, Xue WangABSTRACT How infectious diseases shape individual minds and behaviors has been of interest to researchers. We conducted four studies to examine whether the threat perception of the COVID-19 pandemic was positively related to pro-environmentalism. Study 1 (N = 1,508) showed that individuals’ threat perception of the pandemic was correlated with their pro-environmental behaviors. Study 2 (N = 241) clarified ...
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Laser-Induced Ignition and Combustion of Single Micron-Sized Al-Li Alloy Particles in High Pressure Air/N2Aerospace Pub Date : 2023-03-17 ,DOI:10.3390/aerospace10030299Dunhui Xu, Fang Wang, Shengji Li, Xuefeng Huang, Heping Li, Yanhui GuoTo solve the problems associated with micron-sized aluminum (Al), including sintering, agglomeration, and slag deposition during the combustion of aluminized propellants, aluminum–lithium (Al-Li) alloy, prepared by introducing a small amount of Li (1.0 wt.%) into Al, was used in place of Al. Then, the ignition and combustion characteristics of single micron-sized Al-Li alloy particles were investigated ...
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Melatonin Protects Against Hyperoxia-Induced Apoptosis in Alveolar Epithelial type II Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling PathwayLung (IF 3.777) Pub Date : 2023-03-17 ,DOI:10.1007/s00408-023-00610-0Fan He, Qiao-Fang Wang, Lin Li, Cong Yu, Chun-Zi Liu, Wen-Chao Wei, Li-Ping Chen, Huan-Yu LiPurpose Hyperoxia-induced apoptosis in alveolar epithelial type II cells (AECIIs) plays a critical role in the development of bronchopulmonary dysplasia (BPD). Melatonin has been shown to improve BPD. However, the protective effect of melatonin on hyperoxia-induced apoptosis in AECIIs and the precise mechanisms involved remain unclear. Methods Human alveolar epithelial type II A549 cells were treated ...
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Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1Cell Reports (IF 9.995) Pub Date : 2023-03-16 ,DOI:10.1016/j.celrep.2023.112274Xiaojing Cui, Cuiping Zhang, Fang Wang, Xinghui Zhao, Shuxia Wang, Jinpeng Liu, Daheng He, Chi Wang, Feng-Chun Yang, Sheng Tong, Ying Liang
Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate to all blood cell types. HSCs and their differentiated progeny show sex/gender differences. The fundamental mechanisms remain largely unexplored. We previously reported that latexin (Lxn) deletion increased HSC survival and repopulation capacity in female mice. Here, we find no differences in HSC function and hematopoiesis
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Predicting the fate and transport of indoor DEHP considering their interaction with particles under different ventilation modesEnergy and Buildings (IF 7.201) Pub Date : 2023-03-15 ,DOI:10.1016/j.enbuild.2023.112982Subei Bu, Yanling Wang, Haiyan Wang, Fang Wang, Yufei TanVentilation are widely used in residential buildings to dilute indoor pollutants. While the dynamic partition model of semi-volatile organic compounds (SVOCs) for homes with a central forced-air handling system is still far from adequate. Here we developed a mechanistic model of SVOCs considering dynamic behaviours of size-resolved particles brought by ventilation. In this model, effects of air changes ...
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Construction of an enhanced computed tomography radiomics model for non-invasively predicting granzyme A in head and neck squamous cell carcinoma by machine learningEuropean Archives of Oto-Rhino-Laryngology (IF 3.236) Pub Date : 2023-03-15 ,DOI:10.1007/s00405-023-07909-xRen Hang, Guo Bai, Bin Sun, Peng Xu, Xiaofeng Sun, Guoxin Yan, Wenhao Zhang, Fang WangPurpose Classical prognostic indicators of head and neck squamous cell carcinoma (HNSCC) can no longer meet the clinical needs of precision medicine. This study aimed to establish a radiomics model to predict Granzyme A (GZMA) expression in patients with HNSCC. Methods We downloaded transcriptomic data of HNSCC patients from The Cancer Genome Atlas for prognosis analysis and then used corresponding ...
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Changes and net ecosystem productivity of terrestrial ecosystems and their influencing factors in China from 2000 to 2019Frontiers in Plant Science (IF 6.627) Pub Date : 2023-03-15 ,DOI:10.3389/fpls.2023.1120064Yutao Huang, Fang Wang, Lijuan Zhang, Junfang Zhao, Hong Zheng, Fan Zhang, Nan Wang, Jiakai Gu, Yufeng Zhao, Wenshuai Zhang
Changes in net ecosystem productivity (NEP) in terrestrial ecosystems in response to climate warming and land cover changes have been of great concern. In this study, we applied the normalized difference vegetation index (NDVI), average temperature, and sunshine hours to drive the C-FIX model and to simulate the regional NEP in China from 2000 to 2019. We also analyzed the spatial patterns and the
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Comprehensive characterization of B7 family members in NSCLC and identification of its regulatory networkScientific Reports (IF 4.996) Pub Date : 2023-03-15 ,DOI:10.1038/s41598-022-26776-wMintao Xiao, Chunrong Pang, Shixin Xiang, Yueshui Zhao, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Fang Wang, Qinglian Wen, Zhangang Xiao, Zhongming Yang, Jing Shen
B7 family members act as co-stimulatory or co-inhibitory molecules in the adaptive immune system. Thisstudy aimed to investigate the dysregulation, prognostic value and regulatory network of B7 family members in non-small cell lung cancer (NSCLC). Data for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) patients were extracted from public databases. Patient prognosis was determined
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Effects of vitamin A on intramuscular fat development in beef cattle: A meta-analysisFrontiers in Veterinary Science (IF 3.471) Pub Date : 2023-03-15 ,DOI:10.3389/fvets.2023.1105754Wei Li, Fang Wang, Fang Sun, Yongli Qu, Chunhai Liu, Yongsheng Han, Hongbao Wang, Botao Jiang, Peng Zhong, Jiahui Wang, Xueying Song, Meng Huang, Deli Ding
Vitamin A, a fat-soluble vitamin, is the basic substance required to maintain healthy vision and the main physiological functions of cattle. The results from previous studies regarding the effect of vitamin A on intramuscular fat varied. This meta-analysis aimed to generate a more comprehensive understanding of the relationship between vitamin A and intramuscular fat content and to provide potential
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