- 作 者: "yan wu"
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Spliceosomal GTPase Eftud2 regulates microglial activation and polarization.Neural Regeneration Research (IF 6.058) Pub Date : 2023-04-01 ,DOI:10.4103/1673-5374.347739Guo-Chao Yang,Yuan Shi,Chao-Nan Fan,Ying Li,Meng-Qi Yuan,Jie Pei,Yan Wu,Hai-Tao Wu
Elongation factor Tu GTP binding domain protein 2 (Eftud2) is a spliceosomal GTPase that serves as an innate immune modulator restricting virus infection. Microglia are the resident innate immune cells and the key players of immune response in the central nervous system. However, the role of Eftud2 in microglia has not been reported. In this study, we performed immunofluorescent staining and western
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bFGF combined with extracellular matrix-inspired mimetic systems for effective skin regeneration and wound healingMaterials Today Communications (IF 3.662) Pub Date : 2023-03-23 ,DOI:10.1016/j.mtcomm.2023.105876Donghui Bian, Yan Wu, Guodong SongIt was found that extracellular matrix (ECM) has a key function in organizing the in vivo signaling of growth factors (GFs) by releasing them in an extremely controlled spatiotemporal manner as well as by modulation of their intracellular signaling. Therefore, ECM has inspired researchers to design and develop effective GF delivery systems. Among various GFs, basic fibroblast growth factor (bFGF), ...
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Direct Hydrodefluorination of CF3-Alkenes via a Mild SN2′ Process Using Rongalite as a Masked Proton ReagentOrganic Letters (IF 6.072) Pub Date : 2023-03-23 ,DOI:10.1021/acs.orglett.3c00645Xiang-Long Chen, Dong-Sheng Yang, Bo-Cheng Tang, Chun-Yan Wu, Huai-Yu Wang, Jin-Tian Ma, Shi-Yi Zhuang, Zhi-Cheng Yu, Yan-Dong Wu, An-Xin WuA concise and efficient hydrodefluorination process was developed for the synthesis of gem-difluoroalkenes. This reaction employs rongalite as a masked proton source and does not require any additional catalysts or reductants. Notably, trifluoromethyl alkenes having both terminal and internal double bonds are compatible with this process, allowing for a wider range of substrates. The successful late-stage ...
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Evaluation of 30% supramolecular salicylic acid followed by 1565-nm non-ablative fractional laser on facial acne and subsequent enlarged poresLasers in Medical Science (IF 2.555) Pub Date : 2023-03-22 ,DOI:10.1007/s10103-023-03751-zQixin Han, Jing Zeng, Yifei Liu, Jiali Yin, Peihong Sun, Yan WuThe treatment of acne vulgaris and enlarged pore remains challenging. The 30% supramolecular salicylic acid (SSA) is a newly developed form of SA which affects pathogenic factors of acne. Non-ablative fractional laser (NAFL) promotes remodeling and decreases sebum excretion with minimal side effect. The current study was aimed to evaluate the sequential modality with 30% SSA followed by 1565-nm NAFL ...
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Design and Characterization of a Novel Venetoclax-Zanubrutinib Nano-Combination for Enhancing Leukemic Cell Uptake and Long-Acting Plasma ExposurePharmaceutics (IF 6.525) Pub Date : 2023-03-22 ,DOI:10.3390/pharmaceutics15031016James Griffin, Yan Wu, Qingxin Mu, Xinyan Li, Rodney J. Y. HoLeukemia remains incurable partly due to difficulties in reaching and maintaining therapeutic drug concentrations in the target tissues and cells. Next-generation drugs targeted to multiple cell checkpoints, including the orally active venetoclax (Bcl-2 target) and zanubrutinib (BTK target), are effective and have improved safety and tolerability compared to conventional, nontargeted chemotherapies ...
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Papain Exerts an Anti-atherosclerosis Effect with Suppressed MPA-mediated Foam Cell Formation by Regulating the MAPK and PI3K/Akt-NF-κB PathwaysExpert Opinion on Therapeutic Targets (IF 6.797) Pub Date : 2023-03-22 ,DOI:10.1080/14728222.2023.2194531Xianming Fei, Lianlian Pan, Wufen Yuan, Yan Zhao, Lei Jiang, Qinghua Huang, Yan Wu, Guoqing RuAbstract Background Papain possesses a potential anti-atherosclerosis (AS) effect. This study aimed to explore the inhibitory effects of papain on the monocyte-platelet aggregates (MPAs)-mediated production of foam cells in vitro and AS in vivo. Research design and methods THP-1 cells were induced or treated by platelet, papain, nuclear factor-κB (NF-κB, p65) inhibitor, or NF-κB activator. An AS rat ...
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Epigenetic Up-Regulation of ADAMTS4 in Sympathetic Ganglia is Involved in the Maintenance of Neuropathic Pain Following Nerve InjuryNeurochemical Research (IF 4.414) Pub Date : 2023-03-22 ,DOI:10.1007/s11064-023-03896-xChen Wang, Ming Wei, Yan Wu, Hai-Ting Fan, Zheng-Kai Liang, An-Ran Liu, Wen-Jun Xin, Xia FengSympathetic axonal sprouting into dorsal root ganglia is a major phenomenon implicated in neuropathic pain, and sympathetic ganglia blockage may relieve some intractable chronic pain in animal pain models and clinical conditions. These suggest that sympathetic ganglia participated in the maintenance of chronic pain. However, the molecular mechanism underlying sympathetic ganglia-mediated chronic pain ...
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Resistance training improves hypertrophic and mitochondrial adaptation in skeletal muscle.International Journal of Sports Medicine (IF 2.997) Pub Date : 2023-03-21 ,DOI:10.1055/a-2059-9175Yong-Cai Zhao,Yan-Yan WuResistance training is employed for pursuing muscle strength characterized by activation of mammalian target of rapamycin (mTOR)-mediated hypertrophic signaling for protein production. Endurance training elevates peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) signaling of mitochondrial adaptations for oxidative phosphorylation. Now, emerging evidence suggests that, like endurance ...
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Multi-Conflict-Based Optimal Algorithm for Multi-UAV Cooperative Path PlanningDrones Pub Date : 2023-03-21 ,DOI:10.3390/drones7030217Xiaoxiong Liu, Yuzhan Su, Yan Wu, Yicong Guo
Multi-UAV cooperative path planning can improve the efficiency of task completion. To deal with the space and time conflicts of multi-UAVs in complex environments, a multi-collision-based multi-UAV cooperative path planning algorithm, multi-conflict-based search (MCBS), is proposed. First, the flight and cooperative constraints of UAV are analyzed, and a three-dimensional environment model is established
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Oxymatrine-fatty acid deep eutectic solvents as novel penetration enhancers for transdermal drug delivery: formation mechanism and enhancing effectInternational Journal of Pharmaceutics (IF 6.51) Pub Date : 2023-03-21 ,DOI:10.1016/j.ijpharm.2023.122880Bin Li, Ting Xiao, Shiqi Guo, Yan Wu, Rongrong Lai, Ziyi Liu, Weixuan Luo, Yuehong XuTransdermal delivery of drugs is commonly limited by low skin permeability. The aim of the study was to synthesize deep eutectic solvents (DESs) based on oxymatrine (OMT) and fatty acids with various alkyl chain lengths (LCFAs) as novel vehicles, to solubilize the water-insoluble drug and enhance percutaneous penetration. Quercetin (QUE) was selected as a model drug. Combining differential scanning ...
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CO2 capture using biochar derived from conditioned sludge via pyrolysisSeparation and Purification Technology (IF 9.136) Pub Date : 2023-03-21 ,DOI:10.1016/j.seppur.2023.123624Chang Liu, Chuan Fu, Tingzhen Li, Panyue Zhang, Yaping Xia, Yan Wu, Qiaojuan Lan, Yurong Li, Yuexin Zhang, Jiacheng GuiTo reduce pollution and simultaneously mitigate carbon emission. Biochar samples were prepared via the pyrolysis of sludge after conditioning with K2FeO4 and cationic polyacrylamide (CPAM) or chitosan (CTS), and their CO2 capture performance was compared. The optimal preparation conditions were 600 °C and 80 mg/g dry solid (DS) for K2FeO4, 20 mg/L for CPAM, and 1 mg/g DS for CTS. The results showed ...
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Clinical efficacy of ertapenem versus other carbapenems for the treatment of extended-spectrum-β-lactamase-producing Enterobacterales infection: A systematic review and meta-analysisJournal of Global Antimicrobial Resistance (IF 4.349) Pub Date : 2023-03-21 ,DOI:10.1016/j.jgar.2023.03.003Po-Yu Huang, Chi-Kuei Hsu, Ting-Hui Liu, Jheng-Yan Wu, Hung-Jen Tang, Ya-Wen Tsai, Chih-Cheng Lai, Yi-Hsin ChangBackground Both ertapenem and other carbapenems, including imipenem, meropenem, and doripenem, are recommended in the treatment of extended-spectrum-β-lactamase (ESBL)-producing Enterobacterales infection. However, whether ertapenem is as effective as other carbapenems for ESBL-producing Enterobacterales remains unclear. Therefore, this meta-analysis was conducted to compare the clinical efficacy of ...
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C4 expansion of Central Asia in the middle Miocene linked to the strengthening Indian monsoonGlobal and Planetary Change (IF 4.956) Pub Date : 2023-03-21 ,DOI:10.1016/j.gloplacha.2023.104096Jian Wang, Xinying Zhou, Shiqi Wang, Hai Xu, Hermann Behling, Jie Ye, Yan Zheng, Junchi Liu, Yan Wu, Keliang Zhao, Ran Zhang, Xiaoqiang LiThe water vapor source in Central Asia (CA) during the middle Miocene Climatic Optimum (MMCO) is debated. We investigated the Duolebulejin (DLB) section in the Junggar Basin, dated to 18.8–13.2 million years ago (Ma), to reconstruct the history of the vegetation using analyses of multiple indices including pollen, soil organic matter carbon isotopes (δ13CSOM) and magnetic susceptibility (MS). Results ...
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Syntheses and characterization of dithienyl-blocked hexapyrrin and its mononuclear complexesJournal of Porphyrins and Phthalocyanines (IF 1.914) Pub Date : 2023-03-21 ,DOI:10.1142/s1088424623500335Yanping Huang, Yating Fu, Bin Zhu, Glib Baryshnikov, Hao-Ling Sun, Feng Sha, Chengjie Li, Xin-Yan Wu, Hans Ågren, Qizhao Li, Yongshu XieWith the purpose to develop long chain-conjugated oligopyrrin-like compounds and their metal complexes, and thus achieve tunable near-infrared absorption, a dithienyl-blocked hexapyrrane S2-P6 was synthesized by acid-catalyzed [2+4+2] condensation, followed by oxidation with DDQ to afford dithiaoctapyrrin 1, and its mononuclear metal complexes 1-Cu and 1-Zn were synthesized by treating 1 with Cu(II) ...
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Corruption, the digital sectors, and the profitability of foreign subsidiaries in emerging marketsJournal of Business Research (IF 10.969) Pub Date : 2023-03-20 ,DOI:10.1016/j.jbusres.2023.113848Yan Wu, Yong Yang, Tomasz MickiewiczUtilising institutional theory, we reconsider the relationship between foreign subsidiary profitability and host country corruption, and offer two key insights. First, when corruption is at a medium level, the profitability of foreign subsidiaries is strongly negatively affected, consistent with prospect theory. However, when corruption is widespread and becomes an uncertainty-reducing norm, subsidiary ...
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Quantized control for networked switched systems under denial-of-service attacks via a barrier event-triggered mechanismNonlinear Analysis: Hybrid Systems (IF 5.477) Pub Date : 2023-03-20 ,DOI:10.1016/j.nahs.2023.101343Wen-Hui Wang, Yan-Wu Wang, Xiao-Kang Liu, Zhi-Wei LiuThis paper studies the quantized control problem for networked switched systems (NSSs) under denial-of-service (DoS) attacks. The quantized state information, together with the switching signal, is transmitted to the controller through a network. In order to reduce communication consumption and controller update frequency, a barrier event-triggered mechanism is utilized to monitor the state at discrete ...
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Performance Analysis of LDPC-Coded OFDM in Underwater Wireless Optical CommunicationsPhotonics (IF 2.14) Pub Date : 2023-03-20 ,DOI:10.3390/photonics10030330Jianzhong Guo, Jinpeng Xiao, Jing Chen, Xin Shan, Dejin Kong, Yan Wu, Yong AiThe performance of Low-Density Parity-Check (LDPC)-coded Orthogonal Frequency Division Multiplexing (OFDM) is investigated over turbulence channels in underwater wireless optical communications (UWOC). The relation between the bit error ratio (BER) and parameters such as the scintillation coefficient, signal-to-noise ratio (SNR), length of LDPC code, and order of OFDM is quantified by simulation. Results ...
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Kinase-Modulated Bioluminescent Indicators Enable Noninvasive Imaging of Drug Activity in the BrainACS Central Science (IF 18.728) Pub Date : 2023-03-20 ,DOI:10.1021/acscentsci.3c00074Yan Wu, Joel R. Walker, Michael Westberg, Lin Ning, Michelle Monje, Thomas A. Kirkland, Michael Z. Lin, Yichi Su
Aberrant kinase activity contributes to the pathogenesis of brain cancers, neurodegeneration, and neuropsychiatric diseases, but identifying kinase inhibitors that function in the brain is challenging. Drug levels in blood do not predict efficacy in the brain because the blood-brain barrier prevents entry of most compounds. Rather, assessing kinase inhibition in the brain requires tissue dissection
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Rac1/PAK1 signaling contributes to bone cancer pain by Regulation dendritic spine remodeling in ratsMolecular Pain (IF 3.37) Pub Date : 2023-03-20 ,DOI:10.1177/17448069231161031Lingfei Xu, Long Yang, Yan Wu, Xinxin Wan, Xihui Tang, Yuqing Xu, Qingsong Chen, Yuepeng Liu, Su LiuBone cancer pain (BCP) is severe chronic pain caused by tumor metastasis to the bones, often resulting in significant skeletal remodeling and fractures. Currently, there is no curative treatment. T... ...
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A first-in-human clinical study of an intranasal spray of a cocktail containing two synergetic antibodies neutralizes Omicron BA.4/5medRxiv - Respiratory Medicine Pub Date : 2023-03-20 ,DOI:10.1101/2023.03.17.23287398Xinghai Zhang, Feiyang Luo, Huajun Zhang, Hangtian Guo, Junhui Zhou, Tingting Li, Shaohong Chen, Shuyi Song, Meiying Shen, Yan Wu, Yan Gao, Xiaojian Han, Yingming Wang, Chao Hu, Xiaodong Zhao, Huilin Guo, Dazhi Zhang, Yuchi Lu, Wei Wang, Kai Wang, Ni Tang, Tengchuan Jin, Menglu Ding, Shuhui Luo, Cuicui Lin, Tingting Lu, Bingxia Lu, Yang Tian, Chengyong Yang, Guofeng Cheng, Haitao Yang, Aishun Jin,
Neutralizing monoclonal antibodies (NAbs) with prophylactic and therapeutic efficacy have demonstrated fundamental importance in the control of SARS-CoV-2 transmission. However, their wide application has been largely limited by high cost and inconvenience in administration. Here, we developed an intranasal spray containing two synergetic human NAbs that could broadly neutralize the emerging Omicron
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The Beneficial Effects of a Multispecies Probiotic Supplement on Glycaemic Control and Metabolic Profile in Adults with Type 1 Diabetes: A Randomised, Double-Blinded, Placebo-Controlled Pilot-StudyDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy (IF 3.249) Pub Date : 2023-03-18 ,DOI:10.2147/dmso.s400119Xiuzhen Zhang, Ying Zhang, Limei Luo, Ying Le, Ying Li, Fengyi Yuan, Yan Wu, Ping Xu
Objective: In this pilot-study, the effects of a multispecies probiotic supplement on glycaemic control and metabolic parameters in adults with type 1 diabetes (T1DM) were explored. Material and Methods: A total of 50 T1DM patients were enrolled and randomly placed into a group receiving capsules containing multi-probiotic strains (Bifidobacterium longum, Lactobacterium bulagricumi, Streptococcus thermophilus)
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N-acetyl-L-cysteine attenuates oxidative stress-induced bone marrow endothelial cells apoptosis by inhibiting BAX/caspase 3 pathwayBiochemical and Biophysical Research Communications (IF 3.322) Pub Date : 2023-03-17 ,DOI:10.1016/j.bbrc.2023.03.045Kai Zhao, Dong Han, Si-Rui He, Long-Yan Wu, Wu-Yang Liu, Zhao-Ming ZhongBone marrow endothelial cells (BMECs) play a crucial role in the maintenance of bone homeostasis. The decline in BMECs is associated with abnormal bone development and loss. At present, the mechanism of age-related oxidative stress enhancement in BMEC dysfunction remains unclear. Our experiment explored injury caused by oxidative stress enhancement in BMECs both in vivo and in vitro. The BMECs, indicators ...
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Effect of Potassium Ferrate as a Dewatering Conditioner on Sludge Pyrolysis Characteristics and the Releasing Characteristics of Nitrogen, Sulfur, and Chlorine during Sewage Sludge PyrolysisProcesses (IF 3.352) Pub Date : 2023-03-17 ,DOI:10.3390/pr11030920Hua Zhang, Wenpan Tao, Mingming Hou, Maoqian Ran, Chi Chen, Jingcui Liu, Liang Tu, Lan Huang, Peiyao Deng, Dan Chen, Yan WuSludge pyrolysis is a promising method for treating excess sludge as a by-product of municipal sewage plants, allowing for energy self-sufficiency and resource recovery. Before sludge pyrolysis begins, a few conditioning agents are added to the sludge that promote sludge dewatering. Potassium ferrate (K2FeO4) is applied as a conditioning agent with both cracking and flocculation effects, but the effects ...
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Large tissue archiving solution for multiplexed labeling and super-resolution imagingbioRxiv - Bioengineering Pub Date : 2023-03-17 ,DOI:10.1101/2022.11.28.518189Ya-Hui Lin, Li-Wen Wang, Yen-Hui Chen, Yi-Chieh Chan, Shang-Hsiu Hu, Sheng-Yan Wu, Chi-Shiun Chiang, Guan-Jie Huang, Shang-Da Yang, Shi-Wei Chu, Kuo-Chuan Wang, Chin-Hsien Lin, Pei-Hsin Huang, Hwai-Jong Cheng, Bi-Chang Chen, Li-An Chu
Tissue clearing and expansion microscopy have significantly advanced neuroscience by enabling the visualization of spatial information about biological components, from tissue-level architecture to nanoscale structures. Currently, their application is limited to tissues without prolonged fixation, which excludes long-term preserved specimens, such as human brains. To address this issue, we present
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Influence Mechanism of (NH4)2SO4 on the Composition and Structure of Fe-Co AlloysCoatings (IF 3.236) Pub Date : 2023-03-16 ,DOI:10.3390/coatings13030629Yan Wu, Xue Qiao, Wei WangFe-Co alloys have the advantages of high saturation magnetization and high magnetic elongation. They are used in electromagnet pole heads, earphone vibration films, magnetostriction transducers, and so on. At present, few papers have been published on the co-deposition process of Fe-Co alloys. In the present work, smooth dense Fe-Co films of 10 μm were successfully prepared in an economical, green ...
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Amino accelerators and antioxidants in sediments from the Dong Nai River System, Vietnam: Distribution and influential factorsEnvironmental Research (IF 8.431) Pub Date : 2023-03-16 ,DOI:10.1016/j.envres.2023.115712Ruihe Jin, Yue Li, Yoshiki Saito, Zhanghua Wang, Thi Kim Oanh Ta, Van Lap Nguyen, Jing Yang, Min Liu, Yan WuAmino accelerators and antioxidants (AAL/Os) have become a suite of contaminants of emerging concern recently due to the accumulating evidence for their environmental occurrence and associated toxic potential. Nevertheless, data on sedimentary deposition of AAL/Os has remained scarce, particularly for regions beyond the North America. In the present study, we elucidated spatial distribution of fifteen ...
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Farmland Shelterbelt Changes in Soil Properties: Soil Depth-Location Dependency and General Pattern in Songnen Plain, Northeastern ChinaForests (IF 3.282) Pub Date : 2023-03-15 ,DOI:10.3390/f14030584Yan Wu, Wenjie Wang, Qiong Wang, Zhaoliang Zhong, Huimei Wang, Yanbo YangAs one of the world’s largest ecological rehabilitation programs, the three-north (Northern China, Northeastern China, and Northwestern China) shelterbelts program in China were not well evaluated on its effects on multiple soil properties. This paper aims to quantify this. Seven hundred twenty soils from paired plots of farmlands and neighbor shelterbelts were sampled from six regions of Songnen Plain ...
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Trace element geochemistry, oxygen isotope and U–Pb geochronology of multistage scheelite: Implications for W-mineralization and fluid evolution of Shizhuyuan W–Sn deposit, South ChinaJournal of Geochemical Exploration (IF 4.166) Pub Date : 2023-03-15 ,DOI:10.1016/j.gexplo.2023.107192Kun-Yan Wu, Biao Liu, Qian-Hong Wu, She-Fa Chen, Hua Kong, Huan Li, Safiyanu Muhammad ElatikpoThe Shizhuyuan oxidized skarn-greisen W–Sn deposit (South China) has widely developed scheelite in the prograde skarn stage, retrograde skarn stage, oxide stage, sulfide-quartz vein stage, greisen stage, and quartz-calcite-fluorite vein stage that are related to the reduced A-Type Qianlishan granite. In this contribution, we used trace elements, oxygen isotopic compositions, and U–Pb isotopes for tracing ...
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Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC.Molecular Carcinogenesis (IF 5.139) Pub Date : 2023-03-15 ,DOI:10.1002/mc.23526Lilan Fan,Panpan Xia,Jing Wang,Shun Xu,Zijian Qiu,Yan Wu,Maohui Feng,Qiu Zhao,Hongling Wang,Xuanfei Li
CircRNAs play an important role in the progression of hepatocellular carcinoma (HCC), however, the role of circ_0007429 in HCC remains unknown. Using bioinformatics tools, we selected circ_0007429 that was most highly expressed in HCC tissues and investigated its role in HCC progression. Immunohistochemistry, plasmid transfection, real-time quantitative PCR, and western blot analysis were used to identify
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