- 作 者: "McCarley, Robin L"
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Surface-induced aggregation of beta amyloid peptide by co-substituted alkanethiol monolayers supported on gold.Langmuir (IF 4.331) Pub Date : 2005 May 1 ,DOI:McMasters, Mariah J, Hammer, Robert P, McCarley, Robin LThe primary pathological characteristic of Alzheimer's disease is the presence in the brain of self-assembled beta amyloid (Abeta) protein fibrils, consisting of 35-43 amino acid residues. The toxicity of the aggregated protein structures has previously been proposed to be related to the interaction of Abeta fibrils with neuronal membranes (phospholipid bilayers). Here, surfaces consisting of self-assembled ...
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Solid-phase reversible immobilization in microfluidic chips for the purification of dye-labeled DNA sequencing fragments.Analytical Chemistry (IF 8.008) Pub Date : 2003 Jul 1 ,DOI:Xu, Yichuan, Vaidya, Bikas, Patel, Ami B, Ford, Sean M, McCarley, Robin L, Soper, Steven AIn this manuscript, we discuss the use of photoactivated polycarbonate (PC) for purification of dye-labeled terminator sequencing fragments using solid-phase reversible immobilization (SPRI) prior to gel electrophoretic sorting of these DNAs. An immobilization bed for the DNA purification was produced by exposing a posted microchannel to UV radiation, which induced a surface photooxidation reaction ...
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Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate) for the detection of low-abundant DNA mutations.Analytical Chemistry (IF 8.008) Pub Date : 2003 Mar 1 ,DOI:Wang, Yun, Vaidya, Bikas, Farquar, Hannah D, Stryjewski, Wieslaw, Hammer, Robert P, McCarley, Robin L, Soper, Steven A, Cheng, Yu-Wei, Barany, FrancisLow-density arrays were assembled into microfluidic channels hot-embossed in poly(methyl methacrylate) (PMMA) to allow the detection of low-abundant mutations in gene fragments (K-ras) that carry point mutations with high diagnostic value for colorectal cancers. Following spotting, the chip was assembled with a cover plate and the array accessed using microfluidics in order to enhance the kinetics ...
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Surface modification and characterization of microfabricated poly(carbonate) devices: manipulation of electroosmotic flow.Analyst (IF 5.227) Pub Date : 2002 Oct ,DOI:Vaidya, Bikas, Soper, Steven A, McCarley, Robin LPoly(carbonate), PC, surfaces are chemically modified by treatment with sulfur trioxide gas. Sulfur trioxide gas sulfonates the aromatic rings of the poly(carbonate) surfaces, making the surfaces more hydrophilic. Sulfonation of the poly(carbonate) surface is confirmed by infrared spectroscopy. The modified polymer surfaces are found to be smoother in comparison to their unmodified counterparts, as ...
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Contact conductivity detection in poly(methyl methacrylate)-based microfluidic devices for analysis of mono- and polyanionic molecules.Analytical Chemistry (IF 8.008) Pub Date : 2002 May 1 ,DOI:Galloway, Michelle, Stryjewski, Wieslaw, Henry, Alyssa, Ford, Sean M, Llopis, Shawn, McCarley, Robin L, Soper, Steven AAn on-column contact conductivity detector was developed for the analysis of various mono- and polyanionic compounds separated by electrophoresis chips fabricated in poly(methyl methacrylate) (PMMA) using hot embossing techniques from Ni electroforms. The detector consisted of a pair of Pt wires (127 microm diameter) with an end-to-end spacing of approximately 20 microm and situated within the fluidic ...
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