- 作 者: ( "chunjiang wang" OR "chun-jiang wang" )
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Clinical characteristics, treatment and outcome of nivolumab-induced myasthenia gravisInvestigational New Drugs (IF 3.651) Pub Date : 2023-03-29 ,DOI:10.1007/s10637-023-01347-6Chunjiang Wang, Hanqing Zeng, Weijin Fang, Liying SongBackground: To investigate the clinical features of nivolumab-induced myasthenia gravis (MG) and provide evidence for the rational use of nivolumab in the clinic. Methods: We collected case reports and case series of nivolumab-induced MG for retrospective analysis by searching Chinese and English databases from 2014 to October 31, 2022. Results: Of the 67 patients included, the median age was 72.5 ...
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Clinical features, diagnosis, and management of pembrolizumab-induced myasthenia gravis.Clinical & Experimental Immunology (IF 5.732) Pub Date : 2023-03-16 ,DOI:10.1093/cei/uxac108Shaoli Zhao,Yulu Zhou,Wei Sun,Zuojun Li,Chunjiang WangMyasthenia gravis (MG) is a rare but life-threatening adverse event with pembrolizumab. What is known about pembrolizumab-induced MG is largely based on case reports. This analysis collected pembrolizumab-induced MG cases from Chinese and English databases published from September 1, 2014, to June 30, 2022. Demographic and clinical information of the patients, management, and outcome data were collected ...
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Enantio- and diastereodivergent synthesis of fused indolizines enabled by synergistic Cu/Ir catalysisChemical Science (IF 9.969) Pub Date : 2023-03-14 ,DOI:10.1039/d3sc00118kBing-Ke Zhu, Hui Xu, Lu Xiao, Xin Chang, Liang Wei, Huailong Teng, Yanfeng Dang, Xiu-Qin Dong, Chun-Jiang Wang
Highly diastereo-/enantioselective assembly of 2,3-fused indolizine derivatives could be easily available through a cascade allylation/Friedel–Crafts type reaction enabled by a synergistic Cu/Ir catalysis. This designed protocol provides an unprecedented and facile route to enantioenriched indolizines bearing three stereogenic centers in moderate to high yields with excellent stereoselective control
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IL-17 inhibitor-associated inflammatory bowel disease: A study based on literature and database analysisFrontiers in Pharmacology (IF 5.988) Pub Date : 2023-03-07 ,DOI:10.3389/fphar.2023.1124628Zhenzhen Deng, Shengfeng Wang, Cuifang Wu, Chunjiang Wang
Objective: Few real-world studies have shown clear association between interleukin (IL)-17 inhibitors and inflammatory bowel disease (IBD) onset. This study investigated the reporting prevalence and evaluated the clinical features and management of IL-17 inhibitor-related IBD events. Methods: We used the US FDA Adverse Event Reporting System database and retrieved data, from 2015 to 2022, on IL-17
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Clinical features, risk factors, diagnosis, and treatment of trimethoprim-sulfamethoxazole-induced hypoglycemiaFrontiers in Endocrinology (IF 6.055) Pub Date : 2023-02-08 ,DOI:10.3389/fendo.2023.1059522Chunjiang Wang, Weijin Fang, Zuojun Li, Linli Sun
ObjectiveHypoglycemia is a sporadic and serious adverse reaction of trimethoprim-sulfamethoxazole (TMP-SMX) due to its sulfonylurea-like effect. This study explored the clinical characteristics, risk factors, treatment, and prognosis of TMP-SMX-induced hypoglycemia.MethodsCase reports and series of TMP-SMX-induced hypoglycemia were systematically searched using Chinese and English databases. Primary
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Acid sphingomyelinase promotes diabetic cardiomyopathy via NADPH oxidase 4 mediated apoptosisCardiovascular Diabetology (IF 8.949) Pub Date : 2023-02-02 ,DOI:10.1186/s12933-023-01747-1Ruijiao Liu, Tengfei Duan, Li Yu, Yongzhong Tang, Shikun Liu, Chunjiang Wang, Wei-Jin Fang
Increased acid sphingomyelinase (ASMase) activity is associated with insulin resistance and cardiac dysfunction. However, the effects of ASMase on diabetic cardiomyopathy (DCM) and the molecular mechanism(s) underlying remain to be elucidated. We here investigated whether ASMase caused DCM through NADPH oxidase 4-mediated apoptosis. We used pharmacological and genetic approaches coupled with study
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Enantio- and Diastereoselective De Novo Synthesis of 3-Substituted Proline Derivatives via Cooperative Photoredox/Brønsted Acid Catalysis and EpimerizationJournal of the American Chemical Society (IF 16.383) Pub Date : 2023-01-27 ,DOI:10.1021/jacs.2c12995Chao Che, Yi-Nan Lu, Chun-Jiang WangHerein, a novel strategy for the catalytic asymmetric synthesis of enantioenriched 3-cis- and 3-trans-substituted prolines has been successfully established via an unprecedented cascade radical addition/cyclization enabled by synergistic photoredox/Brønsted acid catalysis and subsequent base-assisted epimerization. The current protocol provides a unique de novo access to all four stereoisomers of 3-substituted ...
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Distribution of microbes and antimicrobial susceptibility in patients with diabetic foot infections in South ChinaFrontiers in Endocrinology (IF 6.055) Pub Date : 2023-01-24 ,DOI:10.3389/fendo.2023.1113622Wei Liu, Liying Song, Wei Sun, Weijin Fang, Chunjiang Wang
BackgroundTo investigate the distribution of microbes and drug susceptibility in patients with diabetic foot infections (DFI) and provide guidance for clinical empirical treatment and the rational selection of antibacterial drugs.MethodsRetrospective analysis of the pathogenic bacterium distribution and antimicrobial susceptibility isolated from 581 DFI patients with different Wagner grades.ResultsThe
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Double-pole solutions in the modified nonlinear Schrödinger equationWave Motion (IF 2.174) Pub Date : 2022-12-30 ,DOI:10.1016/j.wavemoti.2022.103102Chunjiang Wang, Jian ZhangThis paper is concerned with the modified nonlinear Schrödinger equation with zero boundary condition or non-zero boundary condition, which models Alfvén wave propagating along a magnetic field in cold plasmas. We are interested in the double-pole solutions that are a kind of bound-state solitons. By solving a direct scattering problem, the Jost eigenfunctions and scattering matrix are given, their ...
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Asymmetric transformations enabled by synergistic dual transition-metal catalysisChem Catalysis Pub Date : 2022-11-17 ,DOI:10.1016/j.checat.2022.10.031Liang Wei, Chun-Jiang WangFrom its beginnings in the Sonogashira reaction, synergistic dual transition-metal catalysis has gained increasing prominence and importance. In the past decade, this strategy has been intensively investigated in the enantioselective construction of chemical bonds and has shown an increasing number of novel transformations and yielded greater reactivity, selectivity, and efficiency than traditional ...
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Iridium-Catalyzed Asymmetric Cascade Allylation/Lactonization of Indole Esters: Access to Chiral Tricyclic OxazinoindolonesOrganic Letters (IF 6.072) Pub Date : 2022-11-17 ,DOI:10.1021/acs.orglett.2c03100Fan Xiao, Peiqin Liao, Xiaoguang Lu, Jin Wang, Xiu-Qin Dong, Chun-Jiang WangIr-catalyzed asymmetric cascade allylation/lactonization of indole 2-carboxylates with vinyl cyclic carbonate was successfully developed, which provided efficient access to chiral tricyclic oxazinoindolones with excellent results (up to 85% yield, 99% ee). This protocol could be well extended to pyrroles and other nitrogen-containing aromatic heterocycles. A reasonable reaction pathway was provided ...
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Economic evaluation of FLOT and ECF/ECX perioperative chemotherapy in patients with resectable gastric or gastro-oesophageal junction adenocarcinomaBMJ Open (IF 3.006) Pub Date : 2022-11-01 ,DOI:10.1136/bmjopen-2022-060983Hanqing Zeng, Chunjiang Wang, Li-Ying Song, Su-Jie Jia, Xiaohui Zeng, Qiao Liu
Objective The perioperative chemotherapy with fluorouracil, leucovorin, oxaliplatin plus docetaxel (FLOT) was recommended by the Chinese Society of Clinical Oncology Guidelines for gastric cancer (2018 edition) for patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (class IIA). However, the economic impact of FLOT chemotherapy in China remains unclear. The analysis aimed
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Clinical features, diagnosis and management of amoxicillin-induced Kounis syndromeFrontiers in Pharmacology (IF 5.988) Pub Date : 2022-10-31 ,DOI:10.3389/fphar.2022.998239Chunjiang Wang, Yulu Zhou, Weijin Fang, Zuojun Li, Shaoli Zhao
Background: The available evidence suggests that amoxicillin is often associated with the occurrence of Kounis syndrome (KS). The purpose of this study is to explore the clinical characteristics of KS induced by amoxicillin.Methods: We searched for case reports of amoxicillin-induced KS through Chinese and English databases from 1972 to May 2022.Results: A total of 33 patients with KS were included
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Iridium-Catalyzed Asymmetric Cascade Allylation/Retro-Claisen ReactionJournal of the American Chemical Society (IF 16.383) Pub Date : 2022-10-20 ,DOI:10.1021/jacs.2c08811Zhi-Yuan Yi, Lu Xiao, Xin Chang, Xiu-Qin Dong, Chun-Jiang WangAn enantiomerically enriched 3-hydroxymethyl pentenal unit is one of the key structural cores in plenty of natural products and drug candidates with significant biological activities. However, very few synthetic methodologies for the facile construction of the related skeletons have been reported to date. Herein, an elegant iridium-catalyzed asymmetric cascade allylation/retro-Claisen reaction of readily ...
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In-situ damage self-monitoring of fiber-reinforced composite by integrating self-powered ZnO nanowires decorated carbon fabricComposites Part B: Engineering (IF 11.322) Pub Date : 2022-10-20 ,DOI:10.1016/j.compositesb.2022.110368Xiaoming Chen, Siyi Cheng, Kaiqiang Wen, Chunjiang Wang, Jie Zhang, Han Zhang, Hechuan Ma, Lei Wu, Tianliang Li, Baotong Li, Jinyou ShaoThe tradeoff between damage self-sensing abilities and mechanical properties of composites is still a challenge for incorporating functional materials as potential sensing components. In this work, multifunctional carbon fabric coated with piezoelectric zinc oxide nanowires (ZnO NWs) was integrated into a carbon fiber reinforced composite as simultaneously a self-powered damage sensing component and ...
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Proton pump inhibitors-related subacute cutaneous lupus erythematosus: Clinical characteristics, management, and outcomeJournal of Cosmetic Dermatology (IF 2.189) Pub Date : 2022-10-10 ,DOI:10.1111/jocd.15450Zhenzhen Deng, Aiyuan Guo, Cuifang Wu, Chunjiang WangPrevious knowledge about the association between proton pump inhibitors (PPIs) exposure and subacute cutaneous lupus erythematosus (SCLE) was mainly based on limited case reports or few review studies. We aim to evaluate the clinical characteristics, management, and outcome in patients with PPIs-induced SCLE. ...
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Riemann–Hilbert approach and $$N$$ -soliton solutions of the two-component Kundu–Eckhaus equationTheoretical and Mathematical Physics (IF 0.685) Pub Date : 2022-09-26 ,DOI:10.1134/s0040577922090057Chunjiang Wang, Jian ZhangAbstract We study the two-component Kundu–Eckhaus equation with a zero boundary condition at infinity. Based on the spectral analysis of the Lax pair, a Riemann–Hilbert problem is established. An \(N\)-soliton solution is then obtained by solving the regular and nonregular Riemann–Hilbert problems. ...
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Cooperative Catalyst-Enabled Regio- and Stereodivergent Synthesis of α-Quaternary α-Amino Acids via Asymmetric Allylic Alkylation of Aldimine Esters with Racemic Allylic AlcoholsAngewandte Chemie International Edition (IF 16.823) Pub Date : 2022-09-26 ,DOI:10.1002/anie.202212948Lu Xiao, Xin Chang, Hui Xu, Qi Xiong, Yanfeng Dang, Chun-Jiang WangThe regio- and stereodivergent asymmetric α-allylation of aldimine esters with racemic allylic alcohols was enabled by cooperative catalysis. The Et3B additive plays a significant role in ionizing allylic alcohols to form electrophilic metal-π-allyl species and simultaneously promotes the formation of nucleophilic Cu-ylides. Computational mechanistic studies revealed the role of the Et3B additive and ...
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Valproic-induced Fanconi syndrome: Clinical features, risk factors, diagnosis and managementFrontiers in Medicine (IF 5.058) Pub Date : 2022-09-16 ,DOI:10.3389/fmed.2022.945244Chunjiang Wang, Yulu Zhou, Liying Song, Zhenzhen Deng, Weijin Fang
Objective Although Fanconi syndrome (FS) induced by valproate (VPA) has occasionally been reported, the detailed clinical features of the disease remain unclear. The aim of this study was to elucidate the clinical features of patients with VPA-induced FS. Methods We searched Chinese and English databases for all original studies, clinical reports, and case reports on VPA-induced FS published before
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Analysis of clinical characteristics of mesalazine-induced cardiotoxicity.Frontiers in Pharmacology (IF 5.988) Pub Date : 2022-09-15 ,DOI:10.3389/fphar.2022.970597Junyu Chen,Tengfei Duan,Weijin Fang,Shikun Liu,Chunjiang Wang
Background: Mesalazine is the first-line inflammatory bowel disease (IBD) treatment. However, it can cause fatal cardiotoxicity. We aimed to analyze the clinical characteristics of mesalazine-induced cardiotoxicity and provide evidence for clinical diagnosis, treatment, and prevention. Methods: We collected Chinese and English literature on mesalazine-induced cardiotoxicity from 1970 to 2021 for retrospective
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Literature review of the clinical characteristics of metformin-induced hepatotoxicity.Frontiers in Pharmacology (IF 5.988) Pub Date : 2022-09-06 ,DOI:10.3389/fphar.2022.969505Chunjiang Wang,Hongyi Deng,Yunfei Xu,Ying Liu
Background: Knowledge of metformin-induced hepatotoxicity is based on case reports. The aim of this study was to investigate the clinical features of metformin-induced hepatotoxicity. Methods: We collected relevant literature on metformin-induced hepatotoxicity published from January 1994 to February 2022 by searching Chinese and English databases. Results: Thirty patients (19 males and 11 females)
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Engineering a selective fluorescent sensor with a high signal-to-background ratio for microalbumin detection and imagingMaterials Chemistry Frontiers (IF 8.683) Pub Date : 2022-08-31 ,DOI:10.1039/d2qm00392aLiang Su, Feiyu Yang, Wei Li, Haiyan Li, Chunjiang Wang, Qiuan Wang, Lin YuanAbnormal concentrations of human serum albumin (HSA) are closely related to the occurrence of various diseases, such as liver cirrhosis and kidney disease. Thus, it is of great importance to monitor HSA in body fluids, especially microalbumin in urine. However, due to the interference of other proteins and the low-polar microenvironment, a high signal-to-background (S/B) ratio and selective detection ...
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Base-promoted cascade β-F-elimination/electrocyclization/Diels–Alder/retro-Diels–Alder reaction: efficient access to δ-carboline derivativesChemical Science (IF 9.969) Pub Date : 2022-08-15 ,DOI:10.1039/d2sc03166cXi-Shang Sun, Xin-Yu Diao, Xiu-Qin Dong, Chun-Jiang Wang
A serendipitous and highly efficient approach for the construction of a variety of δ-carboline derivatives was developed through base-promoted cascade β-F-elimination/electrocyclization/Diels–Alder/retro-Diels–Alder reaction of N-2,2,2-trifluoroethylisatin ketoimine esters with alkynes in good to high yields with excellent regio-/chemoselectivity control. Moreover, a reasonable reaction pathway was
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Clinical features, diagnosis and management of cephalosporin-induced acute generalized exanthematous pustulosisJournal of Clinical Pharmacy and Therapeutics (IF 2.145) Pub Date : 2022-07-31 ,DOI:10.1111/jcpt.13738Haibo Lei, Hongyi Deng, Xiang Liu, Zuojun Li, Chunjiang WangAcute generalized exanthematous pustulosis (AGEP) is a serious and rare adverse reaction of cephalosporins. We aimed to describe the clinical features of cephalosporin-induced AGEP and provide a reference for rational clinical use of cephalosporins. ...
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Analysis of the clinical characteristics of tigecycline-induced hypofibrinogenemiaJournal of Chemotherapy (IF 2.385) Pub Date : 2022-07-29 ,DOI:10.1080/1120009x.2022.2105488Haibo Lei, Xiang Liu, Zuojun Li, Chunjiang WangAbstract Knowledge regarding the association between hypofibrinogenemia and tigecycline is based mainly on case reports. However, the clinical features of tigecycline-induced hypofibrinogenemia are unclear. We collected 20 patients (16 males and 4 females) with tigecycline-induced hypofibrinogenemia by searching the Chinese and English databases from June 2005 to May 2021, with a median age of 63.5 ...
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Clinical features, diagnosis, and management of dasatinib-induced nephrotic syndromeInvestigational New Drugs (IF 3.651) Pub Date : 2022-07-22 ,DOI:10.1007/s10637-022-01288-6Yang He, Weijin Fang, Zuojun Li, Chunjiang WangKnowledge of dasatinib-induced nephrotic syndrome is largely based on case reports. The clinical features of dasatinib-induced nephrotic syndrome are unknown. We collected case reports of 25 patients with nephrotic syndrome and analyzed their clinical characteristics. Overall, the onset of nephrotic syndrome ranged from 10 days to 5 years after dasatinib administration. Nine patients (36.0%) had clinical ...
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Stereodivergent Synthesis of Enantioenriched α-Deuterated α-Amino Acids via Cascade Cu(I)-Catalyzed H–D Exchange and Dual Cu- and Ir-Catalyzed AllylationOrganic Letters (IF 6.072) Pub Date : 2022-07-21 ,DOI:10.1021/acs.orglett.2c02102Cong Fu, Xin Chang, Lu Xiao, Chun-Jiang WangA one-pot Cu-mediated H–D exchange with inexpensive heavy water as the deuterium source, followed by Cu- and Ir-catalyzed stereodivergent allylic alkylation, has been developed, providing efficient access to enantioenriched α-deuterium-labeled α-amino acids from readily available glycine imine esters in a high yield with excellent stereoselectivity. High deuterium enrichment, exquisite regioselectivity ...
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Diagnosis and Management of Fingolimod-Associated Macular EdemaFrontiers in Neurology (IF 4.086) Pub Date : 2022-07-15 ,DOI:10.3389/fneur.2022.918086Chunjiang Wang, Zhenzhen Deng, Liying Song, Wei Sun, Shaoli Zhao
Objective To investigate the clinical features, treatment, and prognosis of fingolimod-associated macular edema (FAME) and to provide a reference for its rational management. Methods FAME-related case reports were included in a pooled analysis by searching Chinese and English databases from 2010 to November 31, 2021. Results The median age of 41 patients was 50 years (range, 21, 67 years), of whom
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Clinical characteristics, management, and outcome of eosinophilic pneumonia associated with daptomycinMedicina Clínica (IF 3.2) Pub Date : 2022-07-12 ,DOI:10.1016/j.medcli.2022.03.017Cuifang Wu, Zuojun Li, Chunjiang Wang, Zhenzhen DengObjective The association between daptomycin exposure and eosinophilic pneumonia (EP) is mainly based on case reports. The purpose of this study was to evaluate the clinical characteristics and provide more evidence for better identify and management of daptomycin-induced eosinophilic pneumonia in clinical practice. Methods Literature from 1991 to October 31, 2021 on EP induced by daptomycin were collected ...
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Analysis of Clinical Features of Non-steroidal Anti-inflammatory Drugs Induced Kounis SyndromeFrontiers in Cardiovascular Medicine (IF 5.846) Pub Date : 2022-07-11 ,DOI:10.3389/fcvm.2022.901522Chunjiang Wang, Weijin Fang, Liying Song, Zhenzhen Deng, Zuojun Li, Linli Sun
Background Current knowledge of Kounis syndrome induced by non-steroidal anti-inflammatory drugs (NSAIDs) is based on case reports. This study aimed to investigate the clinical features of Kounis syndrome. Methods Case reports of the NSAIDs-induced Kounis syndrome were analyzed by searching Chinese and English databases from 1 January 1950 to 31 January 2022. Results The median age of the 45 included
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