- 作 者: ( "hongjing dou" OR "hong-jing dou" )
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Polysaccharide/Lipid Nanoconjugates as Alternative Building Blocks for Highly Biocompatible MicrocapsulesLangmuir (IF 4.331) Pub Date : 2022-07-26 ,DOI:10.1021/acs.langmuir.2c00937Jackeline Soto-Cruz, Vincent Mukwaya, Mehwish Naz, Peipei Zhang, María José López-Brenes, Giovanni Sáenz-Arce, Oscar Rojas-Carrillo, Hongjing DouSaccharide/lipid nanoconjugates are attractive building blocks for the construction of micro- and nanosized structures because of the roles of glycolipids in human body, courtesy of their intrinsic and functional properties. Herein, nanoconjugates based on dextran and oleic acid (Dex-OA) were synthesized via facile amide-linkage chemistry. The resultant Dex-OA micelles could self-assemble into spherical ...
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Hierarchical Structures in Macromolecule-Assembled Synthetic CellsMacromolecular Rapid Communications (IF 5.006) Pub Date : 2022-07-19 ,DOI:10.1002/marc.202270043Xiaolei Yu, Long Zhou, Gangyang Wang, Lei Wang, Hongjing DouBack Cover: Various synthetic cells have been developed as researchers have sought to explore the origin of life. In article number 2100926 by Hongjing Dou and co-workers, hierarchical structures in synthetic cell models that are inspired by living systems are discussed. This thriving field is gradually narrowing the gap between fundamental research and applied science. ...
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Calcium-chelated nanosystem reversing cancer chemoresistance via replenishing intracellular calcium ionsChemical Engineering Journal (IF 16.744) Pub Date : 2022-06-13 ,DOI:10.1016/j.cej.2022.137500Chenglong Wang, Xiaolin Xu, Shuhan Xiong, Peipei Zhang, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Tao Leng, Hongjing Dou, Guoxiong Xu
Chemoresistance is the major reason for the failure of chemotherapy, which is a major cause of death in patients with advanced cancer. However, the current approach to reversing cancer chemoresistance is limited. Calcium ions are indispensable for all physiological activities of the body. Because a calcium concentration was reduced in chemoresistant cancer cells, we fabricated calcium-chelated nanoparticles
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Hierarchical Structures in Macromolecule-Assembled Synthetic CellsMacromolecular Rapid Communications (IF 5.006) Pub Date : 2022-04-20 ,DOI:10.1002/marc.202100926Xiaolei Yu, Long Zhou, Gangyang Wang, Lei Wang, Hongjing DouVarious models of synthetic cells have been developed as researchers have sought to explore the origins of life. Based on the fact that structural complexity is the foundation of higher-order functions, this review focuses on hierarchical structures in synthetic cell models that are inspired by living systems, in which macromolecules are the dominant participants. The underlying advantages and functions ...
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Therapeutic targeting miR130b counteracts diffuse large B-cell lymphoma progression via OX40/OX40L-mediated interaction with Th17 cellsSignal Transduction and Targeted Therapy (IF 38.104) Pub Date : 2022-03-18 ,DOI:10.1038/s41392-022-00895-2Rui Sun, Pei-Pei Zhang, Xiang-Qin Weng, Xiao-Dong Gao, Chuan-Xin Huang, Li Wang, Xiao-Xia Hu, Peng-Peng Xu, Lin Cheng, Lu Jiang, Di Fu, Bin Qu, Yan Zhao, Yan Feng, Hong-Jing Dou, Zhong Zheng, Wei-Li Zhao
MicroRNAs (miRNAs) are involved in lymphoma progression by regulating the tumor microenvironment. Serum miR130b is overexpressed in diffuse large B-cell lymphoma (DLBCL), inducing Th17 cell alterations. To further illustrate its biological significance and therapeutic rationale, miR130b was detected by quantitative real-time PCR in the serum samples of 532 newly diagnosed DLBCL patients. The mechanism
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Enhanced Intracellular Reactive Oxygen Species by Photodynamic Therapy Effectively Promotes Chemoresistant Cell Death.International Journal of Biological Sciences (IF 10.75) Pub Date : 2022-01-01 ,DOI:10.7150/ijbs.66602Xiaolin Xu,Chenglong Wang,Peipei Zhang,Xuzhu Gao,Wencai Guan,Fanchen Wang,Xin Li,Jia Yuan,Hongjing Dou,Guoxiong Xu
Anti-cancer chemo-drugs can cause a rapid elevation of intracellular reactive oxygen species (ROS) levels. An imbalance in ROS production and elimination systems leads to cancer cell resistance to chemotherapy. This study aimed to evaluate the mechanism and effect of ROS on multidrug resistance in various human chemoresistant cancer cells by detecting the changes in the amount of ROS, the expression
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Thrombus-Targeting Polymeric Nanocarriers and Their Biomedical Applications in Thrombolytic TherapyFrontiers in Physiology (IF 4.755) Pub Date : 2021-11-30 ,DOI:10.3389/fphys.2021.763085Qixiao Guan, Hongjing DouState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.
Due to the high morbidity and mortality of cardiovascular diseases, there is an urgent need for research on antithrombotic strategies. In view of the short half-life, insufficient drug penetration, poor targeting capabilities, and hemorrhagic side-effects of traditional thrombus treatment methods, the combination of thrombolytic therapy and nanocarriers brought by the development of nanotechnology
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Chemical communication at the synthetic cell/living cell interfaceCommunications Chemistry (IF 7.211) Pub Date : 2021-11-25 ,DOI:10.1038/s42004-021-00597-wVincent Mukwaya, Stephen Mann, Hongjing Dou
Although the complexity of synthetic cells has continued to increase in recent years, chemical communication between protocell models and living organisms remains a key challenge in bottom-up synthetic biology and bioengineering. In this Review, we discuss how communication channels and modes of signal processing can be established between living cells and cytomimetic agents such as giant unilamellar
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Monodisperse ZIF-8@dextran nanoparticles co-loaded with hydrophilic and hydrophobic functional cargos for combined near-infrared fluorescence imaging and photothermal therapyActa Biomaterialia (IF 10.633) Pub Date : 2021-10-10 ,DOI:10.1016/j.actbio.2021.10.006Heze Guo, Lingshan Liu, Qiangqiang Hu, Hongjing DouThe State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.Impressive developments have been achieved with the use of zeolitic imidazolate framework-8 (ZIF-8) as nanocarriers for tumor theranostics in recent decades by incorporating imaging agents and therapeutic drugs within ZIF-8. However, the simultaneous immobilization of hydrophilic and hydrophobic functional molecules into ZIF-8 nanoparticles in water or organic solvents still presents a daunting challenge ...
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Nano-assemblies based on biomacromolecules to overcome cancer drug resistancePolymer International (IF 3.213) Pub Date : 2021-10-07 ,DOI:10.1002/pi.6310Meng Cheng, Hongjing DouState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University Shanghai 200240 P. R. ChinaOvercoming tumor resistance is one of the major challenges encountered in cancer treatment. With the rapid development of nanotechnology in recent years, nano-assemblies have become promising candidates due to their strong potential to overcome the drug resistance of tumors. They have a high degree of adaptability, including size and composition regulation, surface versatility and the possibility of ...
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Cell Coding Arrays Based on Fluorescent Glycan Nanoparticles for Cell Line Identification and Cell Contamination EvaluationACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2021-09-09 ,DOI:10.1021/acsami.1c12674Meng Cheng, Lingshan Liu, Peipei Zhang, Shuhan Xiong, Hongjing DouState Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.Cell lines are applied on a large scale in the field of biomedicine, but they are susceptible to issues such as misidentification and cross-contamination. This situation is becoming worse over time due to the rapid growth of the biomedical field, and thus there is an urgent need for a more effective strategy to address the problem. As described herein, a cell coding method is established based on two ...
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Mixed Solvent Method for Improving the Size Uniformity and Cargo-Loading Efficiency of ZIF-8 NanoparticlesLangmuir (IF 4.331) Pub Date : 2021-08-12 ,DOI:10.1021/acs.langmuir.1c01399Heze Guo, Lingshan Liu, Qiangqiang Hu, Hongjing DouThe State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.Zeolitic imidazolate framework-8 (ZIF-8) nanoparticles with tunable diameters and a uniform morphology were constructed in dimethyl sulfoxide (DMSO)/H2O mixed solvents and were further decorated with dextran to improve their stability and biocompatibility. A series of reaction conditions, including the DMSO content in mixed solvents, molar ratio between precursors, growth time, and decoration of dextran ...
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In Situ Preparation of Composite Redox-Active Micelles Bearing Pd Nanoparticles for the Reduction of 4-NitrophenolLangmuir (IF 4.331) Pub Date : 2021-07-19 ,DOI:10.1021/acs.langmuir.1c01154Jiayi You, Ian Manners, Hongjing DouOwing to the redox activity of the poly(ferrocenylsilane)-based polymer, several noble metal nanoparticles can be successfully prepared. As reported herein, the in situ preparation of Pd nanoparticles was performed using a redox-active platform of poly(ferrocenylmethylethylthiocarboxylpropylsilane) (PFC) micelles. PFC/Pd nanocomposites (NCs) with Pd nanoparticles uniformly dispersed at the surface ...
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Corrigendum to 'Gene/paclitaxel co-delivering nanocarriers prepared by framework-induced self-assembly for the inhibition of highly drug-resistant tumors' [Acta Biomaterialia,103 (2020) 247-258].Acta Biomaterialia (IF 10.633) Pub Date : 2021-07-16 ,DOI:10.1016/j.actbio.2021.06.031Chenglong Wang,Wencai Guan,Jinliang Peng,Yuetan Chen,Guoxiong Xu,Hongjing Dou
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Correction to “Redox-Active Micelle-Based Reaction Platforms for In Situ Preparation of Noble Metal Nanocomposites with Photothermal Conversion Capability”ACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2021-07-01 ,DOI:10.1021/acsami.1c11480Jiayi You, Lingshan Liu, Wanqiu Huang, Ian Manners, Hongjing Dou
The authors regret to report the grant number “17ZR1404100” should be revised as “18JC1413500” in the Acknowledgments. The corrected Acknowledgments should read as follows. We wish to gratefully acknowledge financial support from the National Natural Science Foundation of China (no. 21871180), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning
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Correction to Lectin-Glycan-Mediated Nanoparticle Docking as a Step toward Programmable Membrane Catalysis and Adhesion in Synthetic ProtocellsACS Nano (IF 18.027) Pub Date : 2021-06-24 ,DOI:10.1021/acsnano.1c05172Vincent Mukwaya, Peipei Zhang, Heze Guo, Auphedeous Yinme Dang-i, Qiangqiang Hu, Mei Li, Stephen Mann, Hongjing Dou
The authors regret to report the grant number “17ZR1404100” should be revised to “18JC1413500” in the Acknowledgments section. The corrected section appears below. We wish to gratefully acknowledge financial support from the National Natural Science Foundation of China (No. 21871180), the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning (No
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Erratum to: Fluorescent glycan nanoparticle-based FACS assays for the identification of genuine drug-resistant cancer cells with differentiation potentialNano Research (IF 10.269) Pub Date : 2021-06-24 ,DOI:10.1007/s12274-021-3672-9Chenglong Wang,Wencai Guan,Rong Chen,Yael Levi-Kalisman,Yichun Xu,Liwen Zhang,Min Zhou,Guoxiong Xu,Hongjing DouThe article Fluorescent glycan nanoparticle-based FACS assays for the identification of genuine drug-resistant cancer cells with differentiation potential , written by Chenglong Wang et al., was erroneously originally published electronically on the publisher’s internet portal (currently SpringerLink) on 10 August 2020 with the Acknowledgements. ...
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Obstacles impeding the development of nanocarriers for anticancer drugs.Nanomedicine Pub Date : 2021-06-18 ,DOI:10.2217/nnm-2021-0101Lingshan Liu,Hongjing DouThe State Key Laboratory of Metal Matrix Composites, School of Materials Science & Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
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Redox-Active Micelle-Based Reaction Platforms for In Situ Preparation of Noble Metal Nanocomposites with Photothermal Conversion CapabilityACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2021-03-10 ,DOI:10.1021/acsami.0c21925Jiayi You, Lingshan Liu, Wanqiu Huang, Ian Manners, Hongjing DouPolyferrocenylsilane (PFS)-based polymers are an attractive family of organometallic polymers with unique redox-active properties. Herein, we report a novel amphiphilic redox-active PFS-based homopolymer, poly(ferrocenylmethylethylthiocarboxypropylsilane) (PFC), with a hydrophobic backbone chain and hydrophilic carboxylic acid side groups in each repeating unit. Self-assembly was induced by addition ...
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Biofabrication of Gold Nanotriangles Using Liposomes as a Dual Functional Reductant and StabilizerLangmuir (IF 4.331) Pub Date : 2021-03-08 ,DOI:10.1021/acs.langmuir.1c00104Jackeline Soto-Cruz, Paolo Conejo-Valverde, Giovanni Sáenz-Arce, Hongjing Dou, Oscar Rojas-CarrilloNegatively charged liposomes accomplished both functions as a reducing and stabilizing agent in the synthesis of gold nanotriangles (GNTs). Liposomes are based on a mixture of phospholipids phosphatidylcholine/phosphoglycerol, and they were used as a template phase to perform the GNTs. The method was evaluated under different conditions such as temperature, reaction time, phosphoglycerol chain length ...
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Programmable Membrane-Mediated Attachment of Synthetic Virus-like Nanoparticles on Artificial Protocells for Enhanced ImmunogenicityCell Reports Physical Science (IF 7.832) Pub Date : 2021-01-06 ,DOI:10.1016/j.xcrp.2020.100291Vincent Mukwaya, Peipei Zhang, Lingshan Liu, Auphedeous Yinme Dang-i, Mei Li, Stephen Mann, Hongjing Dou
The programming of protocells to implement and control the functions of living cells through activated membrane receptor signaling remains a challenge for the development of protoliving technologies. Here, we report a synthetic protocell capable of inducing high levels of macrophage activation in vitro. An immunogenic protocell comprising hyaluronic acid (HA)-polymer membrane decorated with synthetic
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Corrigendum to "Scalable dextran-polypyrrole nano-assemblies with photothermal/photoacoustic dual capabilities and enhanced biocompatibility" [Carbohydr. Polym. 241 (2020) 116224].Carbohydrate Polymers (IF 10.723) Pub Date : 2020-12-01 ,DOI:10.1016/j.carbpol.2020.117300Wanqiu Huang,Tao Leng,Miaomiao Gao,Qiangqiang Hu,Lingshan Liu,Hongjing DouThe State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
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Effect of Starvation in Reversing Cancer Chemoresistance Based on Drug-Resistance Detection by Dextran NanoparticlesInternational Journal of Nanomedicine (IF 7.033) Pub Date : 2020-11-20 ,DOI:10.2147/ijn.s283430Chenglong Wang, Xuzhu Gao, Fanchen Wang, Wencai Guan, Hongjing Dou, Guoxiong Xu
Introduction: Chemoresistance leads to chemotherapy failure in patients with cancer. Multidrug resistance (MDR) in cancer is mainly caused by the high expression of P-glycoprotein encoded by the MDR1 gene, which is an ATP-dependent protease. Keeping the stronger invasion and migration abilities of chemoresistant cells in cancer also requires more ATP consumption. Herein, we aimed to reverse resistance
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Fluorescent glycan nanoparticle-based FACS assays for the identification of genuine drug-resistant cancer cells with differentiation potentialNano Research (IF 10.269) Pub Date : 2020-08-10 ,DOI:10.1007/s12274-020-2981-8Chenglong Wang,Wencai Guan,Rong Chen,Yael Levi-Kalisman,Yichun Xu,Liwen Zhang,Min Zhou,Guoxiong Xu,Hongjing DouHerein we develop a unique differentiated-uptake strategy capable of efficient and high-purity isolation of genuine drug-resistant (DR) cells from three types of drug-surviving cancer cells, which include paclitaxel-surviving human ovarian OVCAR-3 cancer cells and human lung carcinoma A549/Taxol cells, and doxorubicin-surviving human immortalized myelogenous leukemia K562/ADR cells. By using this strategy ...
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Cationic Surfactants Based on Ferrocene Containing Thiourea: Synthesis, Self-aggregation, and Antioxidant PropertiesColloids and Surfaces A: Physicochemical and Engineering Aspects (IF 5.518) Pub Date : 2020-07-01 ,DOI:10.1016/j.colsurfa.2020.124760Mehwish Naz, Jahangeer Ali, Saira Fatima, Saira Tabassum, Sameen Nawaz, Amin Badshah, Hongjing DouAbstract Keeping in view the significance of cationic surfactants in various fields of life since the ancient times, here we are reporting the synthesis of a new ferrocenyl thiourea derivative along with an entirely new series of ferrocene based cationic surfactants in which variable alkyl chain lengths are introduced while keeping the head structure same, thus acting as a key to comparative study ...
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High-Order Assembly toward Polysaccharide-Based Complex Coacervate Nanodroplets Capable of Targeting Cancer Cells.Langmuir (IF 4.331) Pub Date : 2020-06-29 ,DOI:10.1021/acs.langmuir.0c01458Lingshan Liu,Yuan Xu,Peipei Zhang,Jiayi You,Wei Li,Yunfeng Chen,Rong Li,Biyu Rui,Hongjing DouHigh-order assembly plays a significant role in the formation of living organisms containing a large number of biomacromolecules and, thus, enlightens the construction of nanomaterials that can load macromolecular payloads at a high efficiency. Herein, by choosing anionic hyaluronic acid (HA) as a model payload, we demonstrated how the electrostatic-interaction-induced high-order assembly can be used ...
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Bio-inspired gene carriers with low cytotoxicity constructed via the assembly of dextran nanogels and nano-coacervatesNanomedicine Pub Date : 2020-06-01 ,DOI:10.2217/nnm-2020-0065Chenglong Wang, Jiayi You, Miaomiao Gao, Peipei Zhang, Guoxiong Xu, Hongjing DouAim: To achieve safe and biocompatible gene carriers. Materials & methods: A core/shell-structured hierarchical carrier with an internal peptide/gene coacervate 'core' and a dextran nanogel 'shell' on the surface has been designed. Results: The dextran nanogels shield coacervate (DNSC) can effectively condense genes and release them in reducing environments. The dextran nanogel-based 'shell' can effectively ...
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Bio-inspired gene carriers with low cytotoxicity constructed via the assembly of dextran nanogels and nano-coacervates.Nanomedicine Pub Date : 2020-05-29 ,DOI:10.2217/nnm-2020-0065Chenglong Wang,Jiayi You,Miaomiao Gao,Peipei Zhang,Guoxiong Xu,Hongjing DouAim: To achieve safe and biocompatible gene carriers. Materials & methods: A core/shell-structured hierarchical carrier with an internal peptide/gene coacervate 'core' and a dextran nanogel 'shell' on the surface has been designed. Results: The dextran nanogels shield coacervate (DNSC) can effectively condense genes and release them in reducing environments. The dextran nanogel-based 'shell' can effectively ...
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Lectin-Glycan-Mediated Nanoparticle Docking as a Step toward Programmable Membrane Catalysis and Adhesion in Synthetic Protocells.ACS Nano (IF 18.027) Pub Date : 2020-05-08 ,DOI:10.1021/acsnano.0c02127Vincent Mukwaya,Peipei Zhang,Heze Guo,Auphedeous Yinme Dang-I,Qiangqiang Hu,Mei Li,Stephen Mann,Hongjing DouThe spontaneous assembly of nanoscale building blocks into continuous semipermeable membranes is a key requirement for the structuration of synthetic protocells. Engineering the functionality and programmability of these building units provides a step toward more complex cell-like entities with adaptive membrane properties. Inspired by the central role of protein (lectin)–carbohydrate interactions ...
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Scalable dextran-polypyrrole nano-assemblies with photothermal/photoacoustic dual capabilities and enhanced biocompatibility.Carbohydrate Polymers (IF 10.723) Pub Date : 2020-04-28 ,DOI:10.1016/j.carbpol.2020.116224Wanqiu Huang,Tao Leng,Miaomiao Gao,Qiangqiang Hu,Lingshan Liu,Hongjing DouThe State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.Polypyrroles have shown great potential in photoacoustic imaging and photothermal therapy owing to its excellent photothermal conversion capabilities. However, the synthesis of polypyrrole-based nano-assemblies which have colloidal stability in biological buffers requires a number of steps, including the polymerization of pyrrole monomers, self-assembly of polypyrrole-based copolymers, and even an ...
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