- 作 者: "xiang zhou"
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Inhibition of pyruvate carboxylase reverses metformin resistance by activating AMPK in pancreatic cancerLife Sciences (IF 6.78) Pub Date : 2023-06-02 ,DOI:10.1016/j.lfs.2023.121817Chang Liu, Xiang Zhou, Huijun Ju, Yifan ZhangAims Pyruvate carboxylase (PC) plays a key role in cancer cell metabolic reprogramming. Whether metabolic reprogramming and PC are related in PDAC is unclear. Here, the effect of PC expression on PDAC tumorigenesis and metabolic reprogramming were evaluated. Materials and methods PC protein expression in PDAC and precancerous tissues was measured through immunohistochemistry. The maximum standardized ...
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EBV-Upregulated B7-H3 Inhibits NK cell-Mediated Antitumor Function and Contributes to Nasopharyngeal Carcinoma Progression.Cancer Immunology Research (IF 12.02) Pub Date : 2023-06-02 ,DOI:10.1158/2326-6066.cir-22-0374Haiwen Chen,Xiaobing Duan,Xiaohong Deng,Yingping Huang,Xiang Zhou,Shanshan Zhang,Xiao Zhang,Pingjuan Liu,Chaopin Yang,Guojun Liu,Qinqin Ren,Yan Xiong,Bo Zhu,Jiexia Zhang,Tong XiangNasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy characterized by the presence of prominent infiltration of lymphocytes, including natural killer (NK) cells. Although NK cells can directly target EBV-infected tumor cells without restriction by the MHC, EBV-positive (EBV+) NPC cells often develop resistance mechanisms that allow them to evade immune surveillance ...
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Implementation and verification of a user-defined element (UEL) for coupled thermal-hydraulic-mechanical-chemical (THMC) processes in saturated geological mediaInternational Journal for Numerical and Analytical Methods in Geomechanics (IF 4.229) Pub Date : 2023-05-30 ,DOI:10.1002/nag.3556Xiang Zhou, Yida ZhangEfficient and accurate modeling of the coupled thermal-hydraulic-mechanical-chemical (THMC) processes in various rock formations is indispensable for designing energy geo-structures such as underground repositories for high-level nuclear wastes. This work focuses on developing and verifying an implicit finite element solver for generic coupled THMC problems in geological settings. Starting from the ...
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STAREG: an empirical Bayesian approach to detect replicable spatially variable genes in spatial transcriptomic studiesbioRxiv - Bioinformatics Pub Date : 2023-05-30 ,DOI:10.1101/2023.05.30.542607Yan Li, Xiang Zhou, Rui Chen, Xianyang Zhang, Hongyuan Cao
Identifying replicable genes that display spatial expression patterns from different yet related spatially resolved transcriptomic studies provides stronger scientific evidence and more powerful inference. We present an empirical Bayesian method, STAREG, for identifying replicable spatially variable genes in data generated from various spatially resolved transcriptomic techniques. STAREG models the
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LK-IB: a hybrid framework with legal knowledge injection for compulsory measure predictionArtificial Intelligence and Law Pub Date : 2023-05-30 ,DOI:10.1007/s10506-023-09362-xXiang Zhou, Qi Liu, Yiquan Wu, Qiangchao Chen, Kun KuangThe interpretability of AI is just as important as its performance. In the LegalAI field, there have been efforts to enhance the interpretability of models, but a trade-off between interpretability and prediction accuracy remains inevitable. In this paper, we introduce a novel framework called LK-IB for compulsory measure prediction (CMP), one of the critical tasks in LegalAI. LK-IB leverages Legal ...
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Decomposed Human Motion Prior for Video Pose Estimation via Adversarial TrainingarXiv - CS - Computer Vision and Pattern Recognition Pub Date : 2023-05-30 ,DOI:arxiv-2305.18743Wenshuo Chen, Xiang Zhou, Zhengdi Yu, Zhaoyu Zheng, Weixi Gu, Kai ZhangEstimating human pose from video is a task that receives considerable attention due to its applicability in numerous 3D fields. The complexity of prior knowledge of human body movements poses a challenge to neural network models in the task of regressing keypoints. In this paper, we address this problem by incorporating motion prior in an adversarial way. Different from previous methods, we propose ...
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Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulationNature Genetics (IF 41.307) Pub Date : 2023-05-29 ,DOI:10.1038/s41588-023-01410-1Giannoulatou, Joséphine Henry, Lijiang Ma, Montgomery Blencowe, Tamiel N. Turley, Min-Lee Yang, Sandesh Chopade, Chris Finan, Peter S. Braund, Ines Sadeg-Sayoud, Siiri E. Iismaa, Matthew L. Kosel, Xiang Zhou, Stephen E. Hamby, Jenny Cheng, Lu Liu, Ingrid Tarr, David W. M. Muller, Valentina d’Escamard, Annette King, Liam R. Brunham, Ania A. Baranowska-Clarke, Stéphanie Debette, Philippe Amouyel, Jeffrey
Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD. Integrative
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Marbling-Net: A Novel Intelligent Framework for Pork Marbling Segmentation Using Images from SmartphonesSensors (IF 3.847) Pub Date : 2023-05-28 ,DOI:10.3390/s23115135Shufeng Zhang, Yuxi Chen, Weizhen Liu, Bang Liu, Xiang ZhouMarbling characteristics are important traits for the genetic improvement of pork quality. Accurate marbling segmentation is the prerequisite for the quantification of these traits. However, the marbling targets are small and thin with dissimilar sizes and shapes and scattered in pork, complicating the segmentation task. Here, we proposed a deep learning-based pipeline, a shallow context encoder network ...
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High Linearity, Low Hysteresis Ti3C2Tx MXene/AgNW/Liquid Metal Self-Healing Strain Sensor Modulated by Dynamic Disulfide and Hydrogen BondsAdvanced Functional Materials (IF 19.924) Pub Date : 2023-05-28 ,DOI:10.1002/adfm.202301587Yanli Wang, Wenjing Qin, Min Yang, Zhenhao Tian, Wenjin Guo, Jinkun Sun, Xiang Zhou, Bin Fei, Baigang An, Ruimin Sun, Shougen Yin, Zunfeng LiuFlexible wearable strain sensors have received extensive attention in human–computer interaction, soft robotics, and human health monitoring. Despite significant efforts in developing stretchable electronic materials and structures, developing flexible strain sensors with stable interfaces and low hysteresis remains a challenge. Herein, Ti3C2Tx MXene/AgNWs/liquid metal strain sensors (MAL strain sensor) ...
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Sarcopenia is Prevalent in Cancer Patients and is Associated with Adverse Prognosis: A Nationwide Survey on Common CancersNutrition (IF 4.893) Pub Date : 2023-05-27 ,DOI:10.1016/j.nut.2023.112107Feng-Min Zhang, Chun-Hua Song, Zeng-Qing Guo, Zhen Yu, Min Weng, Fu-Xiang Zhou, Ming Liu, Ming-Hua Cong, Tao Li, Zeng-Ning Li, Jun-Qiang Chen, Jiu-Wei Cui, Hong-Xia Xu, Wei Li, Han-Ping Shi, Cheng-Le ZhuangObjective: Although previous studies have implicated the negative outcomes of sarcopenia, evidence is limited to one or a few types of cancer. This study aimed to evaluate the distribution and influencing factors of sarcopenia, and explore the relationship between sarcopenia and cancer prognosis in a large oncological population. Methods: This observational cohort study included patients diagnosed ...
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Sarcopenia is Prevalent in Cancer Patients and is Associated with Adverse Prognosis: A Nationwide Survey on Common CancersNutrition: X Pub Date : 2023-05-27 ,DOI:10.1016/j.nut.2023.112107Feng-Min Zhang, Chun-Hua Song, Zeng-Qing Guo, Zhen Yu, Min Weng, Fu-Xiang Zhou, Ming Liu, Ming-Hua Cong, Tao Li, Zeng-Ning Li, Jun-Qiang Chen, Jiu-Wei Cui, Hong-Xia Xu, Wei Li, Han-Ping Shi, Cheng-Le ZhuangObjective: Although previous studies have implicated the negative outcomes of sarcopenia, evidence is limited to one or a few types of cancer. This study aimed to evaluate the distribution and influencing factors of sarcopenia, and explore the relationship between sarcopenia and cancer prognosis in a large oncological population. Methods: This observational cohort study included patients diagnosed ...
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Genetic analysis of dystonia-related genes in Parkinson's diseaseFrontiers in Aging Neuroscience (IF 5.702) Pub Date : 2023-05-26 ,DOI:10.3389/fnagi.2023.1207114Yige Wang, Yuwen Zhao, Hongxu Pan, Qian Zeng, Xiaoxia Zhou, Yaqin Xiang, Zhou Zhou, Qian Xu, Qiying Sun, Jieqiong Tan, Xinxiang Yan, Jinchen Li, Jifeng Guo, Beisha Tang, Qiao Yu, Zhenhua Liu
ObjectiveParkinson's disease (PD) and dystonia are two closely related movement disorders with overlaps in clinical phenotype. Variants in several dystonia-related genes were demonstrated to be associated with PD; however, genetic evidence for the involvement of dystonia-related genes in PD has not been fully studied. Here, we comprehensively investigated the association between rare variants in dystonia-related
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Multi-objectives optimization of parameter design for LLC converter based on data-driven surrogate modelIET Power Electronics (IF 2.112) Pub Date : 2023-05-24 ,DOI:10.1049/pel2.12525Buxiang Zhou, Miao Zhang, Huan Luo, Yiwei Qiu, Shi Chen, Tianlei Zang, Yi Zhou, Xiang ZhouDue to high computation complexity, traditional design methods for LLC converter usually consider limited kinds of performance, and the process for searching the optimal parameter scheme is discrete, which might cause the missing of real optimal solution. In order to solve these problems, a multi-objectives optimization design method for the LLC converter is proposed in this paper. According to the ...
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Extremely Large 3D Cages in Metal–Organic Frameworks for Nucleic Acid ExtractionJournal of the American Chemical Society (IF 16.383) Pub Date : 2023-05-24 ,DOI:10.1021/jacs.3c02128Gaoli Hu, Qi Liu, Yi Zhou, Wei Yan, Yuqing Sun, Shuang Peng, Chengbin Zhao, Xiang Zhou, Hexiang DengThree-dimensional (3D) cages in the mesopore regime (2–50 nm) assembled from molecular building blocks are highly desirable in biological applications; however, their synthesis in crystalline form is quite challenging, as well as their structure characterization. Here, we report the synthesis of extremely large 3D cages in MOF crystals, with internal cage sizes of 6.9, and 8.5 nm in MOF-929; 9.3 and ...
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Discovery and structure–activity relationship studies of novel tetrahydro-β-carboline derivatives as apoptosis initiators for treating bacterial infections1Journal of Integrative Agriculture (IF 4.384) Pub Date : 2023-05-20 ,DOI:10.1016/j.jia.2023.05.031Shan-shan SU, Hong-wu LIU, Jun-rong ZHANG, Pu-ying QI, Yue DING, Zhang Ling, Lin-li YANG, Li-wei LIU, Xiang ZHOU, Song YANG
Developing and excavating new agrochemicals with highly active and safe is an important tactic for protecting crop health and food safety. In this paper, to discover the new bactericide candidates, we designed, prepared a new type of 1,2,3,4-tetrahydro-β-carboline (THC) derivatives and evaluated the in vitro and in vivo bioactivities against the Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas axonopodis
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Discrete Element Simulation of the Relationship between Composition, ITZ Property, and Tensile Behavior of Eco-Friendly UHPC MatrixMaterials (IF 3.748) Pub Date : 2023-05-19 ,DOI:10.3390/ma16103844Xiang Zhou, Ye Shi, Qingchun Hu, Shen Zhang, Xihong Zhang, Lingzhen Meng
To combat global warming, the development of eco-friendly ultra-high performance concrete (UHPC) has become one of the current research hotspots. Understanding the relationship between composition and performance of eco-friendly UHPC from a meso-mechanical point will be of great significance in proposing a more scientific and effective mix design theory. In this paper, the 3D discrete element model
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Patient-reported outcome (PRO)-based symptom assessment in patients with advanced lung cancer receiving first-line combination immunotherapy: a protocol for a multicenter, prospective, observational studyBMC Pulmonary Medicine (IF 3.32) Pub Date : 2023-05-19 ,DOI:10.1186/s12890-023-02432-5Yuanle Deng, Han Hu, Rong Jia, Wei Dai, Dengfeng Wang, Purong Zhang, Peng Zhang, Kai Cheng, Jianning Tang, Yan Wen, Xiang Zhou, Qiuling Shi, Zhujuan Xiong, Jin Zhou
Immunotherapy is currently applied in the first-line treatment regimens for numerous advanced cancers, especially advanced lung cancer. Immune-related adverse events (irAEs) resulting from immunotherapy can vary in severity and cause a substantial symptom burden to patients. However, there are limited data on symptom burden in patients with advanced lung cancer following immunotherapy. To address this
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Discovery of novel 3-(piperazin-1-yl)propan-2-ol decorated carbazole derivatives as new membrane-targeting antibacterial agentsArabian Journal of Chemistry (IF 6.212) Pub Date : 2023-05-18 ,DOI:10.1016/j.arabjc.2023.104991Ying-Guo Ding, Ai-Qun Chen, Na Wang, Zhou-Qing Long, Hong-Wu Liu, Jiao Xie, Shi-Tao Liu, Pu-Ying Qi, Xiang Zhou, Li-Wei Liu, Song Yang
The increasing resistance problems of pathogens have drastically reduced the efficiency of existing drugs and agricultural chemicals, increasing the difficulty of preventing and controlling bacterial diseases. To create effective bactericide alternatives, a series of novel 3-(piperazin-1-yl)propan-2-ol decorated carbazole derivatives was fabricated, and their bioactivities and drug-likeness properties
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Recent Development of Jumping Motions Based on Soft ActuatorsAdvanced Functional Materials (IF 19.924) Pub Date : 2023-05-17 ,DOI:10.1002/adfm.202300156Jingjing Li, Kaiqing Yu, Ge Wang, Wenhui Gu, Zhigang Xia, Xiang Zhou, Zunfeng LiuDrawing inspiration from the jumping motions of living creatures in nature, jumping robots have emerged as a promising research field over the past few decades due to great application potential in interstellar exploration, military reconnaissance, and life rescue missions. Early reviews mainly focused on jumping robots made of lightweight and rigid materials with mechanical components, concentrating ...
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High Performance and Multifunction Moisture-Driven Yin–Yang-Interface Actuators Derived from Polyacrylamide HydrogelSmall (IF 15.153) Pub Date : 2023-05-17 ,DOI:10.1002/smll.202303228Jingjing Li, Guanghao Zhang, Zhanpeng Cui, Lili Bao, Zhigang Xia, Zunfeng Liu, Xiang ZhouHigh actuation performance of a moisture actuator highly depends on the presence of a large property difference between the two layers, which may cause interfacial delamination. Improving interfacial adhesion strength while increasing the difference between the layers is a challenge. In this study, a moisture-driven tri-layer actuator with a Yin–Yang-interface (YYI) design is investigated in which ...
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Acromegaly complicated with fulminant pituitary apoplexy: clinical characteristic analysis and review of literatureEndocrine (IF 3.925) Pub Date : 2023-05-17 ,DOI:10.1007/s12020-023-03379-7Xue-Qing Zheng, Xiang Zhou, Yong Yao, Kan Deng, Hui You, Lian Duan, Hui-Juan Zhu
Purpose To retrospectively summarize the clinical features of acromegaly complicated with fulminant pituitary apoplexy and analyze the prognostic factors to guide early identification and timely treatment of such patients. Methods A retrospective analysis was carried out to summarize the clinical manifestations, hormone changes, imaging, treatment and follow-up of ten patients with acromegaly complicated
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Human Umbilical Cord Mesenchymal Stem Cells Protect against Renal Ischemia-Reperfusion Injury by Secreting Extracellular Vesicles Loaded with miR-148b-3p That Target Pyruvate Dehydrogenase Kinase 4 to Inhibit Endoplasmic Reticulum Stress at the Reperfusion StagesInternational Journal of Molecular Sciences (IF 6.208) Pub Date : 2023-05-17 ,DOI:10.3390/ijms24108899Wei Shi, Xiang Zhou, Xinyuan Li, Xiang Peng, Guo Chen, Yang Li, Chunlin Zhang, Haitao Yu, Zhenwei Feng, Xin Gou, Jing Fan
Renal ischemia-reperfusion (I/R) injury is a leading cause of acute kidney injury (AKI), with high mortality. Recent studies have reported that human umbilical cord mesenchymal stem cells (HucMSCs) play an important role in repairing organ and tissue injuries because of their unique characteristics. However, the potential of HucMSC extracellular vesicles (HucMSC-EVs) to promote the repair of renal
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Assembly-level analysis on temperature coefficient of reactivity in a graphite-moderated fuel salt reactor fueled with low-enriched uraniumNuclear Science and Techniques (IF 2.389) Pub Date : 2023-05-16 ,DOI:10.1007/s41365-023-01216-0Xiao-Xiao Li, De-Yang Cui, Chun-Yan Zou, Jian-Hui Wu, Xiang-Zhou Cai, Jin-Gen Chen
To provide a reliable and comprehensive data reference for core geometry design of graphite-moderated and low-enriched uranium fueled molten salt reactors, the influences of geometric parameters on the temperature coefficient of reactivity (TCR) at an assembly level were characterized. A four-factor formula was introduced to explain how different reactivity coefficients behave in terms of the fuel
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Utilizing Epigenetic Modification as a Reactive Handle To Regulate RNA Function and CRISPR-Based Gene RegulationJournal of the American Chemical Society (IF 16.383) Pub Date : 2023-05-16 ,DOI:10.1021/jacs.3c01864Qianqian Qi, Xingyu Liu, Fang Fu, Wei Shen, Shuangyu Cui, Shen Yan, Yutong Zhang, Yuhao Du, Tian Tian, Xiang ZhouThe current methods to control RNA functions in living conditions are limited. The new RNA-controlling strategy presented in this study involves utilizing 5-formylcytidine (f5C)-directed base manipulation. This study shows that malononitrile and pyridine boranes can effectively manipulate the folding, small molecule binding, and enzyme recognition of f5C-bearing RNAs. We further demonstrate the efficiency ...
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Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1Biomarker Research (IF 8.633) Pub Date : 2023-05-16 ,DOI:10.1186/s40364-023-00490-9Xiang Zhou, Seungbin Han, Nadine Cebulla, Larissa Haertle, Maximilian J. Steinhardt, Daniel Schirmer, Eva Runau, Leon Flamm, Calvin Terhorst, Laura Jähnel, Cornelia Vogt, Silvia Nerreter, Eva Teufel, Emilia Stanojkovska, Julia Mersi, Umair Munawar, Magnus Schindehütte, Robert Blum, Ann-Kristin Reinhold, Oliver Scherf-Clavel, Heike L. Rittner, Mirko Pham, Leo Rasche, Hermann Einsele, Claudia Sommer
We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also had a homozygous mutated rs915854 genotype. Homozygous mutated genotypes of rs2839629 and rs915854 were
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Power law in a bounded range: Estimating the lower and upper bounds from sample dataThe Journal of Chemical Physics (IF 4.304) Pub Date : 2023-05-15 ,DOI:10.1063/5.0151614Huan-Xiang Zhou
Power law distributions are widely observed in chemical physics, geophysics, biology, and beyond. The independent variable x of these distributions has an obligatory lower bound and, in many cases, also an upper bound. Estimating these bounds from sample data is notoriously difficult, with a recent method involving O(N3) operations, where N denotes sample size. Here I develop an approach for estimating
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The 2-year postoperative left heart function in marginal donor heart recipients assessing by speckle tracking echocardiographyThe International Journal of Cardiovascular Imaging (IF 2.316) Pub Date : 2023-05-15 ,DOI:10.1007/s10554-023-02867-1Xin Jiang, Yan-xiang Zhou, Qing Zhou, Sheng CaoThis study analyzed the differences and explored the donor/recipient factors between marginal and standard donor heart recipients after heart transplantation (HT) by speckle tracking echocardiography (STE). Seventy-two HT patients were enrolled: 25 standard and 47 marginal donor heart recipients. Thirty HT patients completed 2-year continuous follow-up (1, 6, 12, 24 months). Thirty healthy volunteers ...
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18F-FDG PET/CT imaging in neuroendocrine prostate cancer: Relation to histopathology and prognosisThe Prostate (IF 4.012) Pub Date : 2023-05-15 ,DOI:10.1002/pros.24559Kai Shen, Minghao Yu, Yiyi Ji, Xiang Zhou, Bo Liu, Weiwei Zhang, Ruopeng Su, Jun Qi, Qi Wang, Wei XueThis study aimed to evaluate the effectiveness of 18F-fluoro-2-deoxy-D-glucose Positron emission tomography/computed tomography (18F-FDG PET/CT) in predicting prognosis and characterizing the intratumoral glucose uptake of neuroendocrine prostate cancer (NEPC). ...
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A universal energy response model for determining the energy nonlinearity and resolution of $$e^\pm $$ and $$\gamma $$ in liquid scintillator detectorsThe European Physical Journal C (IF 4.991) Pub Date : 2023-05-13 ,DOI:10.1140/epjc/s10052-023-11541-8Miao Yu, Liangjian Wen, Xiang Zhou, Wuming Luo
Energy nonlinearity and resolution in liquid scintillator (LS) detectors are correlated and particle-dependent. A unified energy response model for liquid scintillator detectors has been presented in details. This model has advanced a data-driven approach to calibrate the particle-dependent energy response, using both the monoenergetic \(\gamma \)-ray sources and the continuous \(\beta \) spectra of
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Novel Approach to Enhancing Tight Oil Recovery Using N2-Assisted CO2 Flooding and Its Potential for CO2 StorageEnergy & Fuels (IF 4.654) Pub Date : 2023-05-13 ,DOI:10.1021/acs.energyfuels.3c00312Yongchao Wang, Liehui Zhang, Yulong Zhao, Xiang Zhou, Shijian Lu, Deping Zhang, Jianhua Qin, Zhengdong Lei, Ye TianFour types of gas injection experiments─CO2 flooding, N2 flooding, alternating CO2 and N2 flooding, and CO2 pre-slug N2 flooding─were conducted in a 28.42 cm long core plug to study the production performances of a CO2 and N2 flooding model in enhancing the tight oil flooding efficiency. Experimental results indicate that the following. (1) For CO2 and N2 flooding, the highest tight oil flooding efficiency ...
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