- 作 者: "song wu"
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Identification of GPD1L as a Potential Prognosis Biomarker and Associated with Immune Infiltrates in Lung AdenocarcinomaMediators of Inflammation (IF 4.529) Pub Date : 2023-3-30 ,DOI:10.1155/2023/9162249Zhengyang Fan, Song Wu, Hongyang Sang, Qianping Li, Shaofei Cheng, Hongling ZhuLung adenocarcinoma (LUAD) is one of the most prevalent pathological kinds of lung cancer, which is a common form of cancer that has a high death rate. Over the past several years, growing studies have indicated that GPD1L was involved in the advancement of a number of different cancers. However, its clinical significance in LUAD has not been investigated. In this study, following an examination of ...
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Constructing of Pb-Sn/α-PbO2/β-PbO2-Co2MnO4 composite electrode for enhanced oxygen evolution and zinc electrowinningMaterials Today Physics (IF 11.021) Pub Date : 2023-03-30 ,DOI:10.1016/j.mtphys.2023.101068Xuanbing Wang, Junli Wang, Xiaoning Tong, Song Wu, Jinlong Wei, Buming Chen, Ruidong Xu, Linjing YangDeveloping a highly efficient and stable electrode for oxygen evolution reaction (OER) in harsh conditions (∼1.63 M H2SO4) is desirable but still challenging. Herein, the paper describes Co2MnO4 modifying β-PbO2 (Pb-Sn/α-PbO2/β-PbO2-Co2MnO4) via thermal decomposition and subsequent electrodeposition. Consequently, the synthesized electrode presents a layer structure, where Pb-Sn alloy serves as the ...
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Machine learning- and structure-based discovery of a novel chemotype as FXR agonists for potential treatment of nonalcoholic fatty liver diseaseEuropean Journal of Medicinal Chemistry (IF 7.088) Pub Date : 2023-03-27 ,DOI:10.1016/j.ejmech.2023.115307Tong Qin, Xuefeng Gao, Lei Lei, Jing Feng, Wenxuan Zhang, Yuhua Hu, Zhufang Shen, Zhenming Liu, Yi Huan, Song Wu, Jie Xia, Liangren ZhangFarnesoid X receptor (FXR) is a promising target for drug discovery against nonalcoholic fatty liver disease (NAFLD). However, no FXR agonist has been approved for NAFLD so far. The R & D of FXR agonists are somewhat hindered by the lack of effective and safe chemotypes. To this end, we developed a multi-stage computational workflow to screen the Specs and ChemDiv chemical library for FXR agonists ...
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Combined application of strong alkaline materials and specific organic fertilizer accelerates nitrification process of a rare earth mining soilScience of the Total Environment (IF 10.753) Pub Date : 2023-03-23 ,DOI:10.1016/j.scitotenv.2023.163042Min Wang, Song Wu, Yilin Lu, Haotian Wu, Dunfeng Si, Dongmei ZhouThe extensive usage of ammonium sulfate as the leaching agent to extract rare earth elements led to widespread ammonia nitrogen (NH4+-N) pollution in the tailing soils of ion-adsorbed rare earth deposits in southern China. However, the cost-effective technologies to tackle with the long-term retention of NH4+-N in the rare earth mining soil have been largely unresolved. In this study, we developed ...
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Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signalingMolecular Medicine (IF 6.376) Pub Date : 2023-03-23 ,DOI:10.1186/s10020-023-00633-6Xu Cao, Song Wu, Xinxing Wang, Junjie Huang, Wenxiu Zhang, Chi Liang
Chronic inflammation, mainly derived from fibroblast-like synoviocytes (FLSs), plays a central role in the pathomechanism of osteoarthritis (OA). Recently, epithelial-mesenchymal transition (EMT) signaling was found to be activated in OA-derived FLSs with a pro-inflammatory phenotype. However, the role of EMT signaling in regulating FLS function and OA-related inflammation remains unknown. The synovium
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Dual-Ligand-Functionalized Liposomes Based on Glycyrrhetinic Acid and cRGD for Hepatocellular Carcinoma Targeting and TherapyMolecular Pharmaceutics (IF 5.364) Pub Date : 2023-03-23 ,DOI:10.1021/acs.molpharmaceut.2c00842Mingxing Qiu, Jiong Wang, Jiaojiao Bai, Xiaoxu Li, Cuiqing Tian, Zhi Liu, Chaoran Zheng, Andrew R. Clark, Xinwei Cheng, Xiaoyan Liao, Song Wu, Robert J. Lee, Xiaoju ZhouHepatocellular carcinoma (HCC) is one of the most common cancers, with high mortality. Chemotherapy is one of the main treatment options for HCC. However, the high toxicity and poor specificity of chemotherapeutic drugs have limited their clinical application. In this study, dual-ligand liposomes modified with glycyrrhetinic acid (GA) and cyclic arginine–glycine–aspartic acid (cRGD) (GA/cRGD-LP) were ...
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Phenylboronic Acid-Functionalized Chitosan for Enabling Transmucosal Delivery for Cancer TherapyMaterials & Design (IF 9.417) Pub Date : 2023-03-21 ,DOI:10.1016/j.matdes.2023.111843Wenqi Jiang, Mingkang Liang, Qifang Lei, Dashi Deng, Chenchen Li, Yuqing Li, Siming Yuan, Kai Wu, Guangzhi Li, Song Wu
Mucosa administration and transmucosal polymeric carriers demonstrate specific advantages in locoregional therapy, which, however, suffer from unsatisfactory transmucosal delivery efficiency and limited hydrophobic or bio-macromolecular drug loading. Herein, we demonstrate several phenylboronic acid-modified chitosan derivatives to screen out a self-assembly nano-system. The phenylboronic acid unit
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Cuproptosis signature and PLCD3 predicts immune infiltration and drug responses in osteosarcomaFrontiers in Oncology (IF 5.738) Pub Date : 2023-03-16 ,DOI:10.3389/fonc.2023.1156455Hai Hu, Yuesong Yin, Binbin Jiang, Zhennan Feng, Ting Cai, Song Wu
Osteosarcoma (OS) is a cancer that is frequently found in children and adolescents and has made little improvement in terms of prognosis in recent years. A recently discovered type of programmed cell death called cuproptosis is mediated by copper ions and the tricarboxylic acid (TCA) cycle. The expression patterns, roles, and prognostic and predictive capabilities of the cuproptosis regulating genes
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β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTENExperimental Gerontology (IF 4.253) Pub Date : 2023-03-15 ,DOI:10.1016/j.exger.2023.112140Guang Xia, Zi Wen, Lina Zhang, Junjie Huang, Xinxing Wang, Chi Liang, Xiaoyu Cui, Xu Cao, Song Wu
Senescence chondrocytes play an important role in Osteoarthritis (OA) progression. However, alleviating OA progression through senescent chondrocyte intervention still faces great challenges. β-Hydroxybutyrate (BHB) exhibits anti-senescence effects in a variety of age-related dis-eases, but its role in osteoarthritis remains poorly understood. To explore the molecular mechanisms, gene sequencing was
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Bioengineered bacterial outer membrane vesicles encapsulated Polybia–mastoparan I fusion peptide as a promising nanoplatform for bladder cancer immune-modulatory chemotherapyFrontiers in Immunology (IF 8.786) Pub Date : 2023-03-14 ,DOI:10.3389/fimmu.2023.1129771Chunyu Ren, Yangyang Li, Zhaoqing Cong, Zhuoran Li, Leiming Xie, Song Wu
BackgroundNanosized bacterial outer membrane vesicles (OMVs) secreted by Gram-negative bacteria have emerged as a novel antitumor nanomedicine reagent due to their immunostimulatory properties. The encapsulated bacterial composition in OMVs can be edited via manipulating bioengineering technology on paternal bacteria, allowing us to design an ingenious antitumor platform by loading the Polybia–mastoparan
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Highly stable, substrate-free, and flexible broadband halide perovskite paper photodetectorsNanoscale (IF 8.307) Pub Date : 2023-03-14 ,DOI:10.1039/d2nr07008aLam-Gia-Hao Dao, Chih-Hao Chiang, Sumedh M. Shirsat, Thi-Quynh-Hoa Nguyen, Jitendra Singh, Han-Song Wu, Yu-Lun Liu, Meng-Lin TsaiIn this work, we aim to fabricate a highly stable and flexible perovskite paper photodetector based on a Zn-doped MA0.6FA0.4PbI3 perovskite and CNC. The paper photodetector has been successfully synthesized by the vacuum filtration method and deposited with interdigitated electrodes. The paper photodetector exhibits a significant photoresponse with a responsivity of 0.23 A W−1 under 650 nm light irradiation ...
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Inoculation with Rhizophagus intraradices Confers Drought Stress Tolerance in Oat by Improving Nitrogen and Phosphorus NutritionJournal of Soil Science and Plant Nutrition (IF 3.61) Pub Date : 2023-03-14 ,DOI:10.1007/s42729-023-01160-3Bin Zhang, Yu-Feng Lv, Yue Li, Li Li, Ju-Qing Jia, Mei-Chen Feng, Chao Wang, Xiao-Yan Song, Wu-De Yang, Fahad Shafiq, Mei-Jun ZhangThis study determined the effects of arbuscular mycorrhizal (AM) fungi inoculation on the N and P contents in the soil–plant continuum and its subsequent effect on oat grain yield under drought stress. Separate experiments were conducted during the oat growing seasons (2020 and 2021) in which AM fungi inoculation with Rhizophagus intraradices was performed in soil with 75% and 55% relative water contents ...
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Novel arginase inhibitor, AZD0011, demonstrates immune cell stimulation and anti-tumor efficacy with diverse combination partners.Molecular Cancer Therapeutics (IF 6.009) Pub Date : 2023-03-13 ,DOI:10.1158/1535-7163.mct-22-0431Aatman S Doshi,Susan Cantin,Marylens Hernandez,Srimathi Srinivasan,Sharon Tentarelli,Matthew Griffin,Yanjun Wang,Petar Pop-Damkov,Laura B Prickett,Cecilia Kankkonen,Minhui Shen,Maryann San Martin,Song Wu,M Paola Castaldi,Hormas Ghadially,Jeffrey Varnes,Sonya Gales,David Henry,Clare Hoover,Deanna A Mele,Iain Simpson,Eric T Gangl,Scott N Mlynarski,M Raymond V Finlay,Lisa Drew,Stephen E Fawell,WenlinAnti-tumor immunity can be hampered by immunosuppressive mechanisms in the tumor microenvironment including recruitment of arginase (ARG) expressing myeloid cells which deplete L-arginine essential for optimal T cell and natural killer cell function. Hence, ARG inhibition can reverse immunosuppression enhancing anti-tumor immunity. We describe AZD0011, a novel peptidic boronic acid prodrug to deliver ...
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FDC-SP as a diagnostic and prognostic biomarker and modulates immune infiltrates in renal cell carcinomaBMC Bioinformatics (IF 3.307) Pub Date : 2023-03-10 ,DOI:10.1186/s12859-023-05215-1Fan Chang, Jiang-Hui Zhang, Wen-Song Wu, Shuai Tang, Zheng lv, Fang-Min ChenRenal cell carcinoma (RCC), one of the top 10 causes of cancer death, is responsible for more than 90% of all cases of primary renal cancer worldwide. Follicular dendritic cell-secreted protein (FDC-SP) specifically binds to activated B cells and regulates the generation of antibodies. It is also thought to promote cancer cell invasion and migration, which could help with tumor metastases. This study ...
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Identifying, Resolving, and Quantifying Anisotropy in ReS2 Nanomechanical ResonatorsSmall (IF 15.153) Pub Date : 2023-03-10 ,DOI:10.1002/smll.202300631Bo Xu, Jiankai Zhu, Fei Xiao, Chenyin Jiao, Yachun Liang, Ting Wen, Song Wu, Zejuan Zhang, Lin Lin, Shenghai Pei, Hao Jia, Ying Chen, Ziming Ren, Xueyong Wei, Wen Huang, Juan Xia, Zenghui WangAs an emerging two-dimensional semiconductor, rhenium disulfide (ReS2) is renowned for its strong in-plane anisotropy in electrical, optical, and thermal properties. In contrast to the electrical, optical, optoelectrical, and thermal anisotropies that are extensively studied in ReS2, experimental characterization of mechanical properties has largely remained elusive. Here, it is demonstrated that the ...
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An immune infiltration-related prognostic model of kidney renal clear cell carcinoma with two valuable markers: CAPN12 and MSCFrontiers in Oncology (IF 5.738) Pub Date : 2023-03-07 ,DOI:10.3389/fonc.2023.1161666Guang Xia, Song Wu, Xiaoyu Cui
Background Since its discovery, clear cell renal cell carcinoma (ccRCC) has been the most prevalent and lethal kidney malignancy. Our research aims to identify possible prognostic genes of ccRCC and to develop efficient prognostic models for ccRCC patients based on multi-omics investigations to shed light on the treatment and prognosis of ccRCC. Methods To determine a risk score for each patient, we
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Selective Clearance of Senescent Chondrocytes in Osteoarthritis by Targeting Excitatory Amino Acid Transporter Protein 1 to Induce Ferroptosis.Antioxidants & Redox Signaling (IF 7.468) Pub Date : 2023-03-02 ,DOI:10.1089/ars.2022.0141Zi Wen,Guang Xia,Chi Liang,Xinxing Wang,Junjie Huang,Lina Zhang,Dongyong Shan,Song Wu,Xu CaoAims: This study aimed at exploring the mechanism of ferroptosis (an iron-dependent form of nonapoptotic cell death) resistance in senescent chondrocytes (SenChos). Results: In this study, by utilizing metabolomics and single-cell RNA sequencing, we found that hyperactivation of ferroptosis metabolism was one of the most prominent metabolic features in SenChos. Interestingly, however, SenChos were ...
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Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancersEuropean Journal of Pharmacology (IF 5.195) Pub Date : 2023-02-28 ,DOI:10.1016/j.ejphar.2023.175628Qihong Yang, Tong Qin, Tao An, Hongna Wu, Gang Xu, Jin Xiang, Kangfan Lei, Shaohua Zhang, Jie Xia, Guifeng Su, Dan Wang, Minggao Xue, Lingmei Kong, Wenxuan Zhang, Song Wu, Yan LiWnt/β-catenin signaling pathway is a classical and crucial oncogenic pathway in many carcinomas, and Porcupine (PORCN) is an O-acyltransferase, which is indispensable and highly specific for catalyzing palmitoylation of Wnt ligands and facilitating their secretion and biofunction. Targeting PORCN provides a promising approach to specifically cure Wnt-driven cancers from the root. In this study, we ...
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Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers.European journal of pharmacology Pub Date : 2023-02-28 ,DOI:10.1016/j.ejphar.2023.175628Qihong Yang,Tong Qin,Tao An,Hongna Wu,Gang Xu,Jin Xiang,Kangfan Lei,Shaohua Zhang,Jie Xia,Guifeng Su,Dan Wang,Minggao Xue,Lingmei Kong,Wenxuan Zhang,Song Wu,Yan LiWnt/β-catenin signaling pathway is a classical and crucial oncogenic pathway in many carcinomas, and Porcupine (PORCN) is an O-acyltransferase, which is indispensable and highly specific for catalyzing palmitoylation of Wnt ligands and facilitating their secretion and biofunction. Targeting PORCN provides a promising approach to specifically cure Wnt-driven cancers from the root. In this study, we ...
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Development and Verification of a Prognostic Stemness-Related Gene Signature in Triple-Negative Breast CancerJournal of Oncology (IF 4.501) Pub Date : 2023-2-25 ,DOI:10.1155/2023/6242355Xueqi Ou, Yeru Tan, Guanfeng Gao, Song Wu, Jinhui Zhang, Hailin Tang, Hongbo Zhu, Anli Yang
Background. It is well known that cancer stem cells can induce cancer metastasis, which causes the majority of cancer-related death, especially in triple-negative breast cancer (TNBC). TNBC features a high metastatic rate and low metastasis-free survival and is regarded as the most malignant subtype of breast cancer. The purpose of this study is to explore prognostic biomarkers that can predict metastasis
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Enabling Balanced Data Deduplication in Mobile Edge ComputingIEEE Transactions on Parallel and Distributed Systems (IF 3.757) Pub Date : 2023-02-22 ,DOI:10.1109/tpds.2023.3247061Ruikun Luo, Hai Jin, Qiang He, Song Wu, Xiaoyu XiaIn the mobile edge computing (MEC) environment, edge servers with storage and computing resources are deployed at base stations within users’ geographic proximity to extend the capabilities of cloud computing to the network edge. Edge storage system (ESS), is comprised by connected edge servers in a specific area, which ensures low-latency services for users. However, high data storage overheads incurred ...
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Large twist angle of a novel 3D lattice structure via a tailored buckling modeMechanics of Advanced Materials and Structures (IF 3.338) Pub Date : 2023-02-16 ,DOI:10.1080/15376494.2023.2180553Shuai Kang, Wenfeng Liu, Hongwei Song, Wu Yuan, Cheng Qiu, Te Ma, Zhe Wang, Jiangtao WangAbstract A novel 3D centrosymmetric lattice that exhibits a large twist angle during compression is proposed by tailoring the twist buckling mode of a body-centered cubic lattice and a simple cubic truss to the first. The imperfections of offset and multimaterial systems are introduced to control the twist direction. Effects of geometrical parameters and material properties on twist behavior are studied ...
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“LEARN”, a novel teaching method for Chinese clinical clerkship: A cross-sectional studyFrontiers in Surgery (IF 2.568) Pub Date : 2023-02-13 ,DOI:10.3389/fsurg.2023.1113267Xiangyu Chen, Matthew F. Gong, Song Wu, Jinshen He
BackgroundDespite the clerkship being crucial in the training of a future doctor, no widely accepted education model has been proposed. This study devised a new model for clinical clerkship rotations, titled “LEARN” for Lecture, English-video, Advisor, Real-case and Notion, and evaluated whether the LEARN model is appropriate for medical education in China.MethodsA cross-sectional study was performed
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Deep Learning and Medical Imaging for COVID-19 Diagnosis: A Comprehensive SurveyarXiv - EE - Image and Video Processing Pub Date : 2023-02-13 ,DOI:arxiv-2302.06611Song Wu, Yazhou Ren, Aodi Yang, Xinyue Chen, Xiaorong Pu, Jing He, Liqiang Nie, Philip S. YuCOVID-19 (Coronavirus disease 2019) has been quickly spreading since its outbreak, impacting financial markets and healthcare systems globally. Countries all around the world have adopted a number of extraordinary steps to restrict the spreading virus, where early COVID-19 diagnosis is essential. Medical images such as X-ray images and Computed Tomography scans are becoming one of the main diagnostic ...
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Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero thresholdCell Reports (IF 9.995) Pub Date : 2023-02-10 ,DOI:10.1016/j.celrep.2023.112093Song Wu, Yang Yang, Ruizhi Tang, Song Zhang, Peizhong Qin, Rong Lin, Neus Rafel, Elena M. Lucchetta, Benjamin Ohlstein, Zheng Guo
Apical-basal polarity and cell-fate determinants are crucial for the cell fate and control of stem cell numbers. However, their interplay leading to a precise stem cell number remains unclear. Drosophila pupal intestinal stem cells (pISCs) asymmetrically divide, generating one apical ISC progenitor and one basal Prospero (Pros)+ enteroendocrine mother cell (EMC), followed by symmetric divisions of
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Stereo- and Regiospecific SN2′ Reaction of MBH Adducts with Isocyanoacetates: en Route to Transition-Metal-Free α-Allylation of IsocyanoacetatesACS Omega (IF 4.132) Pub Date : 2023-02-09 ,DOI:10.1021/acsomega.2c07581Chunsong Xie, Song Wu, Runmei Zhang
Herein, we report that under mild and transition-metal-free conditions an unprecedented and practical SN2′ reaction of Morita–Baylis–Hillman adducts with isocyanoacetates takes place in a stereo- and regiospecific manner. This reaction which tolerates a wide variety of functionalities delivers transformable α-allylated isocyanoacetates in high efficiencies. Preliminary studies on the asymmetric version
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Detection of Klebsiella pneumonia DNA and ESBL positive strains by PCR-based CRISPR-LbCas12a systemFrontiers in Microbiology (IF 6.064) Pub Date : 2023-02-09 ,DOI:10.3389/fmicb.2023.1128261Shang Wang, Shan Wang, Ying Tang, Guoyu Peng, Tongyu Hao, Xincheng Wu, Jiehong Wei, Xinying Qiu, Dewang Zhou, Shimao Zhu, Yuqing Li, Song Wu
IntroductionKlebsiella pneumonia (K. pneumonia) is a Gram-negative bacterium that opportunistically causes nosocomial infections in the lung, bloodstream, and urinary tract. Extended-spectrum β-Lactamases (ESBLs)-expressed K. pneumonia strains are widely reported to cause antibiotic resistance and therapy failure. Therefore, early identification of K. pneumonia, especially ESBL-positive strains, is
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Warming changes the composition and diversity of fungal communities in permafrostAnnals of Microbiology (IF 3.168) Pub Date : 2023-02-03 ,DOI:10.1186/s13213-022-01707-2Yunbing Jiang, Libin Yang, Song Wu, Tian Zhou
It is the data support and theoretical basis for the response mechanism of soil fungi to climate warming in permafrost areas in the Greater Xing’an Mountains. We collected permafrost from the Greater Xing’an Mountains for indoor simulation experiments and took the natural permafrost as the control (CK) and the test groups of 0 °C (T1), 2 °C (T2), and 4 °C (T3) were set. Illumina MiSeq high-throughput
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Accumulation of blood chromium and cobalt in the participants with metal objects: findings from the 2015 to 2018 National Health and Nutrition Examination Survey (NHANES)BMC Geriatrics (IF 4.07) Pub Date : 2023-02-03 ,DOI:10.1186/s12877-022-03710-3Jinshen He, Jinfei Li, Song Wu, Jiaoju Wang, Qi Tang
Chromium (Cr) and cobalt (Co) are the essential elements for producing metal implants, but might have potential health issues. The research on the correlation between metal implants and blood Cr and Co on a large population is still limited. National Health and Nutrition Examination Survey (NHANES) is a program of studies designed to assess the health status of Americans began in the early 1960s. The
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Fast Upcycling of Poly(ethylene terephthalate) into Catalyst-Free VitrimersACS Sustainable Chemistry & Engineering (IF 9.224) Pub Date : 2023-01-27 ,DOI:10.1021/acssuschemeng.2c06829Shan-Song Wu, Yi-Dong Li, Zhi Hu, Jian-Bing ZengWe reported a catalyst-free technique to fabricate transesterification-based poly(ethylene terephthalate) (PET) vitrimers via melt reacting PET with N,N′-tetraglycidyldiaminodiphenyl methane (TGDDM) in several minutes. We investigated the effect of TGDDM content on the reaction mechanism and chemical structure of the final products in detail. At low TGDDM content (≤0.5 wt %), branched thermoplastic ...
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