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Endoplasmic reticulum stress triggers delanzomib-induced apoptosis in HCC cells through the PERK/eIF2α/ATF4/CHOP pathway.

American journal of translational research Pub Date : 2020-06-15 ,DOI:

Jun Li,Jian-Yong Zhuo,Wei Zhou,Jia-Wei Hong,Rong-Gao Chen,Hai-Yang Xie,Lin Zhou,Shu-Sen Zheng,Dong-Hai Jiang

For limited clinical benefits and acquired resistance by sorafenib, new therapeutic strategies and molecular targets for the treatment of advanced hepatocellular carcinoma (HCC) are urgently needed. This study aimed to evaluate the potential antitumor effects of the second-generation proteasome inhibitor delanzomib on HCC. The results demonstrated that delanzomib displayed excellent antitumor activity ...
Development of Covalently Cross-linked and Composite Perfluorosulfonic Acid Membranes

ECS Transactions Pub Date : 2019-12-17 ,DOI:10.1149/1.3210703

Yong Ming Zhang,Lei Li,Junke Tang,Bernd Bauer,Wei Zhang,Hong Rong Gao,Melanie Taillades-Jacquin,Deborah J. Jones,Jacques Rozière,Natalia Lebedeva,Ronald Mallant

A straight forward approach to increase proton conductivity at relatively dry conditions is to increase the number of sulfonic acid groups in the polymer. Although various PFSAs of significantly lower EW can be prepared, the limitation of this approach is that the polymer and membrane properties are also affected, with membranes showing increased water uptake and dimensional swelling. Our approach ...
Synthesis of perfluorinated ionomers and their anion exchange membranes

Journal of Membrane Science (IF 10.53) Pub Date : 2016-10-01 ,DOI:10.1016/j.memsci.2016.05.062

Xundao Liu, Hongrong Gao, Xiaohong Chen, Yong Hu, Supeng Pei, Hong Li, Yongming Zhang

Abstract Perfluorinated ionomers (S-PFSO 2 NH - GCI-OH) and their anion exchange membranes (AEMs) were successfully synthesized from short side-chain perfluorosulfonamide polymer for the first time. S-PFSO 2 NH-GCI-OH ionomers well dissolved in many solvents, especially in low-boiling point solvents and formed a transparent solution. The wet membrane of S-PFSO 2 NH-GCI-OH displayed a well defined nano-phase ...
Poly(tetrafluoroethylene-co-perfluorovinyl ether sulfonamide) for anion exchange membranes†

Polymer Chemistry (IF 5.364) Pub Date : 2016-03-30 ,DOI:10.1039/c6py00036c

Xundao Liu,Hongrong Gao,Xiaohong Chen,Yong Hu,Hong Li,Yongming Zhang

A soluble perfluorinated polymer poly(tetrafluoroethylene-co-perfluorovinyl ether sulfonamide) (PFSO2NH2) was successfully synthesized and used for preparation of perfluorinated anion exchange membranes (AEMs). PFSO2NH2 is soluble in many solvents and has excellent alkaline stability. The perfluorinated AEM (PFSO2NH–MGMC–OH) which was synthesized by the reaction of PFSO2NH2 with 4-methyl-4-glycidylmorpholin-4-ium ...
Enabling carbon nanofibers with significantly improved graphitization and homogeneous catalyst deposition for high performance electrocatalysts

Electrochimica Acta (IF 7.336) Pub Date : 2014-11-27 ,DOI:10.1016/j.electacta.2014.11.164

Chaonan Wang,Hongrong Gao,Xiaohong Chen,Wang Zhang Yuan,Yongming Zhang

A facile and effective method is developed for the fabrication of ideal support and corresponding excellent catalysts. After spontaneous deposition of MnO2 onto electrospun carbon nanofibers (CNFs) in a solution of KMnO4 and subsequent thermal annealing, MnO-CNF hybrids with significantly enhanced graphitic structure and homogeneous surfaces defects are obtained. Further treatment with the solutions ...
Graphene nanoribbons hybridized carbon nanofibers: remarkably enhanced graphitization and conductivity, and excellent performance as support material for fuel cell catalysts†

Nanoscale (IF 8.307) Pub Date : 2013-10-31 ,DOI:10.1039/c3nr04663j

Chaonan Wang,Hongrong Gao,Hong Li,Yiren Zhang,Bowen Huang,Junhong Zhao,Yan Zhu,Wang Zhang Yuan,Yongming Zhang

High electronic conductivity of the support material and uniform distribution of the catalyst nanoparticles (NPs) are extremely desirable for electrocatalysts. In this paper, we present our recent progress on electrocatalysts for fuel cells with simultaneously improved conductivity of the supporting carbon nanofibers (CNFs) and distribution of platinum (Pt) NPs through facile incorporation of graphene ...
Synthesis, Structure and Biological Activities of S-[a-(4-Methoxyphenylcarbonyl)-2-(1, 2, 4-triazole-1-yl)] ethyl-N, N-dimethyldithiocarbamate

Chinese Journal of Chemistry (IF 5.56) Pub Date : 26 AUG 201 ,DOI:10.1002/cjoc.20030211218

Liang-Zhong Xu, Fang-Fang Jian, Hong-Rong Gao, Chong-Yi Zhu

The title compound was prepared by reaction of N, N-dimethyldithiocarbamate sodium with l-bromo-l-(4-methoxyphenylcarbonyl)-2-(1, 2, 4-triazole-l-yl) ethane. Its crystal structure has been determined by X-ray diffraction analysis. ...