- 作 者: ( "benhong zhou" OR "ben-hong zhou" )
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Recent advancement in bioeffect, metabolism, stability, and delivery systems of apigenin, a natural flavonoid compound: challenges and perspectivesFrontiers in Nutrition (IF 5.0) Pub Date : 2023-07-26 , DOI:10.3389/fnut.2023.1221227Peng Chen, Fuchao Chen, ZhiLei Guo, Jiexin Lei, Benhong Zhou
Apigenin is a bioflavonoid compound that is widely present in dietary plant foods and possesses biological activities that protect against immune, cardiovascular, and neurodegenerative diseases and cancer. Therefore, apigenin is widely used in food and medicine, and increasing attention has been drawn to developing new delivery systems for apigenin. This review highlights the biological effects, metabolism
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Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging micePhytotherapy Research (IF 7.2) Pub Date : 2023-04-24 , DOI:10.1002/ptr.7848Peng Chen, Fuchao Chen, Jiexin Lei, Benhong ZhouAlzheimer's disease (AD) is an irreversible, progressive brain disorder characterized by loss of memory and cognitive dysfunction in the aged. Despite remarkable advances in drug therapy, effective pharmacological interventions are rare. Punicalagin (PU) is an active antioxidant polyphenol found in pomegranates, raspberries, blueberries, and chestnuts that has attracted considerable attention owing ...
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Dihydrokaempferol attenuates CCl4-induced hepatic fibrosis by inhibiting PARP-1 to affect multiple downstream pathways and cytokinesToxicology and Applied Pharmacology (IF 3.8) Pub Date : 2023-02-24 , DOI:10.1016/j.taap.2023.116438Hancheng Huang, Shuchun Wei, Xiaohan Wu, Mengke Zhang, Benhong Zhou, Debin Huang, Weiguo DongThe pathophysiological mechanism of hepatic fibrosis (HF) is related to the excessive activation of the DNA repair enzyme poly ADP-ribose polymerase-1 (PARP-1). The drugs, targeting PARP-1, are scarce. Therefore, the lead compound, moderately inhibiting PARP-1, with anti-HF properties should be identified. This study screened dihydrokaempferol (DHK) from herbs based on preliminary studies to intervene ...
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Insight into the role of adult hippocampal neurogenesis in aging and Alzheimer's diseaseAgeing Research Reviews (IF 13.1) Pub Date : 2022-12-19 , DOI:10.1016/j.arr.2022.101828Peng Chen, Guo ZhiLei, Benhong ZhouAlzheimer's disease (AD) is the most common form of dementia and seriously affects the quality of life of the elderly. Neurodegeneration is closely related to hippocampal dysfunction in AD patients. The hippocampus is key to creating new memories and is also one of the first areas of the brain to deteriorate with age. Mammalian neurogenesis occurs mainly in the hippocampus. Recent studies have confirmed ...
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Molecular Mechanisms of Luteolin Against Atopic Dermatitis Based on Network Pharmacology and in vivo Experimental ValidationDrug Design, Development and Therapy (IF 4.8) Pub Date : 2022-12-09 , DOI:10.2147/dddt.s387893Liu Tang, Jiefang Gao, Xiaolei Li, Xiaoqin Cao, Benhong Zhou
Purpose: To undercover the underlying mechanisms of luteolin against atopic dermatitis (AD), clinically characterized by recurrent eczematous lesions and intense itching, based on network pharmacology, molecular docking and in vivo experimental validation. Methods: TCMSP, STITCH and SwissTargetPrediction databases were utilized to screen the corresponding targets of luteolin. Targets related to AD
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Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysisFrontiers in Molecular Neuroscience (IF 4.8) Pub Date : 2022-10-10 , DOI:10.3389/fnmol.2022.965697Guanghui Chen, Siqi Zhou, Qiang Chen, Mengmeng Liu, Meixue Dong, Jiabao Hou, Benhong Zhou
Major depression (MD) is a severe mental illness that creates a heavy social burden, and the potential molecular mechanisms remain largely unknown. Lots of research demonstrate that the olfactory bulb is associated with MD. Recently, gas chromatography-mass spectrometry-based metabolomic studies on depressive rats indicated that metabolisms of purine and lipids were disordered in the olfactory bulb
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Development and evaluation of an online training program based on the O-AMAS teaching model for community pharmacists in the post-COVID-19 era.Frontiers in Public Health (IF 5.2) Pub Date : 2022-09-23 , DOI:10.3389/fpubh.2022.906504Bingzheng Shen,Jun Liu,Jiahuan Helen He,Zhanyong Zhu,Benhong Zhou
Background Formerly, the community pharmacists' work was mainly focused on drug supply. However, during the COVID-19 epidemic outbreak, community pharmacists in Wuhan played an important role in control and prevention of SARS-CoV-2 and in providing pharmaceutical care. Due to a lack of adequate knowledge and skills, many community pharmacists were not able to cope with healthcare work timely and efficiently
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Recent Advances and Perspectives on the Health Benefits of Urolithin B, A Bioactive Natural Product Derived From EllagitanninsFrontiers in Pharmacology (IF 5.6) Pub Date : 2022-06-22 , DOI:10.3389/fphar.2022.917266Peng Chen, Zhiei Guo, Fuchao Chen, Yue Wu, Benhong Zhou
Urolithin (Uro) B is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranates, raspberries, blueberries and chestnuts. Uro B has recently garnered considerable attention owing to its wide range of nutraceutical effects and relatively high potency. According to several studies, Uro B prevents the development
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Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review.Journal of Integrative Neuroscience Pub Date : 2022-05-30 , DOI:10.31083/j.jin2104102Peng Chen,Fuchao Chen,Benhong Zhou
Epilepsy is a chronic brain disorder that causes repeated seizures. It affects 65 million people worldwide and is a major burden on individuals and health systems. It has been reported that factors leading to ion channel disfuntion, neuronal damage and are all involved in the pathogenesis of epilepsy. The exact etipathogenic mechanism is unknown and appropriate therapeutic targets remain elusive. Recent
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Serum Metabolomics Analysis of the Anti-Inflammatory Effects of Gallic Acid on Rats With Acute InflammationFrontiers in Pharmacology (IF 5.6) Pub Date : 2022-03-22 , DOI:10.3389/fphar.2022.830439Yue Wu, Kuangyu Li, Maolin Zeng, Boyang Qiao, Benhong Zhou
Background: Gallic acid (GA) is a natural small-molecule polyphenol having a wide range of pharmacological activities. Until now, some works have studied the effect and the mechanisms of GA against inflammation. However, whether or how gallic acid regulates the downstream metabolic disorder against acute inflammation remains unclear. The present study explored the protective effect and the potential
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Correction: Gut microbial metabolite urolithin B attenuates intestinal immunity function in vivo in aging mice and in vitro in HT29 cells by regulating oxidative stress and inflammatory signallingFood & Function (IF 6.1) Pub Date : 2022-01-28 , DOI:10.1039/d2fo90008dPeng Chen, Fuchao Chen, Jiexin Lei, Benhong Zhou
Correction for ‘Gut microbial metabolite urolithin B attenuates intestinal immunity function in vivo in aging mice and in vitro in HT29 cells by regulating oxidative stress and inflammatory signalling’ by Peng Chen et al., Food Funct., 2021, 12, 11938–11955, DOI: 10.1039/D1FO02440J.
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Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathwayPhytotherapy Research (IF 7.2) Pub Date : 2022-01-17 , DOI:10.1002/ptr.7370Yi Zhang, Mengmeng Liu, Yaoyuan Zhang, Mi Tian, Peng Chen, Yu Lan, Benhong ZhouAcute kidney injury (AKI) induced by renal ischemia reperfusion (RIR) is typically observed in renal surgeries and is a leading cause of renal failure. However, there is still an unmet medical need currently in terms of clinical treatments. Herein, we report the effect of Urolithin A (UA) in a mouse RIR model, wherein we demonstrated its underlying mechanism both in vitro and in vivo. The expression ...
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Downregulation of CYP39A1 Serves as a Novel Biomarker in Hepatocellular Carcinoma with Worse Clinical OutcomeOxidative Medicine and Cellular Longevity (IF 7.31) Pub Date : 2021-12-31 , DOI:10.1155/2021/5175581Dan Li, Tao Yu, Junjie Hu, Jie Wu, Shi Feng, Qingxue Xu, Hua Zhu, Xu Zhang, Yonggang Zhang, BenHong Zhou, Lijuan Gu, Zhi Zeng
Background. CYP39A1 is a poorly characterized metabolic enzyme that has been investigated in a few tumors. However, the role of CYP39A1 in hepatocellular carcinoma (HCC) has not yet been clarified. In this study, the expression and clinical significance of CYP39A1 in HCC were explored. Methods. CYP39A1 protein expression was detected in Akt/c-Met-induced HCC mice and 14 paired fresh HCC samples as
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New Insights Into the Role of Aberrant Hippocampal Neurogenesis in Epilepsy.Frontiers in Neurology (IF 3.4) Pub Date : 2021-12-15 , DOI:10.3389/fneur.2021.727065Peng Chen,Fuchao Chen,Yue Wu,Benhong Zhou
Data accumulated over the past four decades have confirmed that adult hippocampal neurogenesis (HN) plays a key role in the wide spectrum of hippocampal pathology. Epilepsy is a disorder of the central nervous system characterized by spontaneous recurrent seizures. Although neurogenesis in persistent germinative zones is altered in the adult rodent models of epilepsy, the effects of seizure-induced
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The Gut Microbiota Metabolite Urolithin B Improves Cognitive Deficits by Inhibiting Cyt C-Mediated Apoptosis and Promoting the Survival of Neurons Through the PI3K Pathway in Aging MiceFrontiers in Pharmacology (IF 5.6) Pub Date : 2021-11-15 , DOI:10.3389/fphar.2021.768097Peng Chen, Fuchao Chen, Jiexin Lei, Gaohua Wang, Benhong Zhou
Background: Despite considerable advances in pharmacotherapy, more effective therapeutic interventions for aging-related neurodegenerative disorders (NDs), such as Alzheimer’s disease (AD), remain limited. Urolithin B (UB), one of the major subcategories of urolithins (microbiota metabolites) found in various tissues after ellagitannin consumption, has been shown to possess antioxidant, anti-inflammatory
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Gut microbial metabolite urolithin B attenuates intestinal immunity function in vivo in aging mice and in vitro in HT29 cells by regulating oxidative stress and inflammatory signallingFood & Function (IF 6.1) Pub Date : 2021-10-14 , DOI:10.1039/d1fo02440jPeng Chen, Fuchao Chen, Jiexin Lei, Benhong ZhouUrolithin B (Uro B), one of the major subcategories of urolithins (microbial metabolites) found in various tissues after ellagitannin consumption, has been demonstrated to possess antioxidant and anti-inflammatory effects. The current research mainly focused on the ameliorative effect of Uro B on intestinal immunity function and exploring the potential mechanisms of its protective role in aging mice ...
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The Tannins from Sanguisorba officinalis L. (Rosaceae): A Systematic Study on the Metabolites of Rats Based on HPLC–LTQ–Orbitrap MS2 AnalysisMolecules (IF 4.6) Pub Date : 2021-07-02 , DOI:10.3390/molecules26134053Jingjing Tu, Qiaoling Li, Benhong Zhou
Sanguisorba tannins are the major active ingredients in Sanguisorba ofJicinalis L. (Rosaceae), one of the most popular herbal medicines in China, is widely prescribed for hemostasis. In this study, three kinds of tannins extract from Sanguisorba officinalis L. (Rosaceae), and the metabolites in vivo and in vitro were detected and identified by high-pressure liquid chromatography, coupled with linear
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Urolithin A attenuates renal fibrosis by inhibiting TGF-β1/Smad and MAPK signaling pathwaysJournal of Functional Foods (IF 5.6) Pub Date : 2021-05-26 , DOI:10.1016/j.jff.2021.104547Zhenzhen Cheng, Jingjing Tu, Hongpan Zhang, Yi zhang, Benhong Zhou
Urolithin A (UA) is a bioavailable product of the metabolism of ellagitannins by the gut microbiota, and UA has anti-inflammatory and antioxidant activities. In this study, we investigated whether UA exerted an anti-renal fibrosis effect in a rat model of unilateral ureteral obstruction (UUO) and HK-2 cells treated with TGF-β1. In vivo, UA treatment significantly ameliorated UUO-induced renal tissue
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Oral absorption mechanism of the polysaccharides from Gastrodia elata Blume base on fluorescence labelingFood Research International (IF 8.1) Pub Date : 2021-03-24 , DOI:10.1016/j.foodres.2021.110342Baiyu Zhang, Mengmeng Liu, Gang Liu, Dan Li, Benhong ZhouThe mechanisms of action of polysaccharides in vivo have been widely elucidated. However, the systematic research of its absorption and transport mechanisms remains unclear. Herein, we extracted a polysaccharide fraction (GEP) from Gastrodia elata by water extraction and alcohol precipitation and aimed to reveal its oral absorption processes through animal models and Caco-2 cells monolayer models. ...
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Prevalence of mental health problems in frontline healthcare workers after the first outbreak of COVID-19 in China: a cross-sectional studyHealth and Quality of Life Outcomes (IF 3.6) Pub Date : 2021-03-22 , DOI:10.1186/s12955-021-01743-7Wen-Ping Guo, Qing Min, Wei-Wei Gu, Liang Yu, Xiao Xiao, Wei-Bing Yi, Hong-Liang Li, Bei Huang, Jun-Li Li, Ya-Jun Dai, Jian Xia, Jie Liu, Bei Li, Ben-Hong Zhou, Minglun Li, Hong-Xi Xu, Xuan-Bin Wang, Wen-Yuan Shi
More than 210,000 medical workers have fought against the outbreak of Coronavirus Disease 2019 (COVID-19) in Hubei in China since December 2019. However, the prevalence of mental health problems in frontline medical staff after fighting COVID-19 is still unknown. Medical workers in Wuhan and other cities in Hubei Province were invited to participate a cross-sectional and convenience sampling online
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Effect of punicalagin on multiple targets in streptozotocin/high-fat diet-induced diabetic miceFood & Function (IF 6.1) Pub Date : 2020-10-21 , DOI:10.1039/d0fo01275kDan Jin, Baiyu Zhang, Qiaoling Li, Jingjing Tu, Benhong ZhouType 2 diabetes has a series of metabolic aberrations accompanied by chronic hyperglycemia, along with various comorbidities. In recent reports, punicalagin from pomegranate has been reported to exert hypoglycemic effects against diabetes. The goal of the current research was to investigate the therapeutic effectiveness and elucidate the mechanisms of punicalagin underlying type 2 diabetes. Type 2 ...
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Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia AdministrationDrug Design, Development and Therapy (IF 4.8) Pub Date : 2020-10-09 , DOI:10.2147/dddt.s248209Peng Chen, Fuchao Chen, Jiexin Lei, Benhong Zhou
Background and Objective: The combination of naloxone hydrochloride (NH) and fentanyl citrate (FC) in patient-controlled analgesia (PCA) is examined to reduce the risk of opioid-induced nausea and vomiting. However, there are no such commercially available drug mixtures, and there is also no published evidence on the compatibility and stability of NH and FC. Thus, the primary purpose of the current
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Gallic Acid Inhibits Bladder Cancer T24 Cell Progression Through Mitochondrial Dysfunction and PI3K/Akt/NF-κB Signaling SuppressionFrontiers in Pharmacology (IF 5.6) Pub Date : 2020-07-27 , DOI:10.3389/fphar.2020.01222Maolin Zeng, Yang Su, Kuangyu Li, Dan Jin, Qiaoling Li, Yan Li, Benhong Zhou
Gallic acid (GA), a hydrolyzable tannin, has a wide range of pharmacological activities. This study revealed that, GA significantly inhibited T24 cells viability in a concentration- and time- dependent manner. The IC50 of GA stimulating T24 cells for 24, 48, and 72 h were 21.73, 18.62, and 11.59 µg/ml respectively, and the inhibition rate was significantly higher than the positive control drug selected
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Sacubitril-Valsartan Compared With Enalapril for the Treatment of Heart Failure: A Decision-Analytic Markov Model Simulation in China.Frontiers in Pharmacology (IF 5.6) Pub Date : 2020-07-06 , DOI:10.3389/fphar.2020.01101Yue Wu,Shuo Tian,Peipei Rong,Fan Zhang,Ying Chen,Xianxi Guo,Benhong Zhou
Objectives Heart failure with reduced ejection fraction (HFrEF) is a major health concern globally due to high mortality rates, frequent hospitalization and considerable medical expenditure. The prevalence of HFrEF is steadily rising in Asian countries, and populous, developing countries like China are facing a significant socio-economic burden as a result. Sacubitril-valsartan (Sac-Val) is currently
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Wuchang Fangcang Shelter Hospital: Practices, Experiences, and Lessons Learned in Controlling COVID-19.SN Comprehensive Clinical Medicine Pub Date : 2020-07-04 , DOI:10.1007/s42399-020-00382-1Bingzheng Shen,Li Chen,Lu Zhang,Mengke Zhang,Jing Li,Jie Wu,Kunlin Chen,Yuanguo Xiong,Wei Song,Benhong Zhou
In early January 2020, the outbreak of the new corona virus pneumonia (Corona Virus Disease 2019, COVID-19) occurred. Wuhan, the capital city of Hubei province, became the epicenter of the disease in China. The rapid growth of patients had exceeded the maximum affordability of local medical resources. A large comprehensive gymnasium was converted into Wuchang Fangcang Shelter Hospital in order to provide
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Pharmacy services at a temporary COVID-19 hospital in Wuhan, China.American Journal of Health-System Pharmacy (IF 2.7) Pub Date : 2020-05-31 , DOI:10.1093/ajhp/zxaa160Jie Wu,Bingzheng Shen,Dan Li,Wei Song,Jing Li,Mengke Zhang,Gang Liu,Benhong Zhou
ark hospitalCOVID-19epidemicpharmacistspharmacy servicespublic health
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Experiences and perceptions risk of health-care workers from coronavirusMedicine (IF 1.6) Pub Date : 2020-05-15 , DOI:10.1097/md.0000000000020308Peng Chen, Jiexin Lei, Fuchao Chen, Benhong Zhou
Abstract Background: Healthcare workers (HCWs) were at the frontline during the battle against coronavirus. Understanding and managing their fears and anxieties may hold lessons for handling future outbreaks. However, the experiences and perceptions risk of HCWs from coronavirus still remains to be controversial. Thus, the objective of this review is to identify, appraise, and synthesize available
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