- 作 者: ( "youjun li" OR "you-jun li" )
-
One-off irrigation improves water and nitrogen use efficiency and productivity of wheat as mediated by nitrogen rate and tillage in drought-prone areasField Crops Research (IF 6.145) Pub Date : 2023-03-22 ,DOI:10.1016/j.fcr.2023.108898Hongtao Wang, Jinzhi Wu, Akang Liu, Xiuli Huang, Guoqiang Li, Shanwei Wu, Jun Zhang, Zhenwang Zhang, Yuanquan Hou, Zhiming Zhao, Shuang Li, Jinhua Guo, Wenxin Zhao, Shujing Li, Wenna Li, Ming Huang, Youjun LiProblem Water deficiency is an important factor limiting wheat production in northern China. Fortunately, at present, one-off irrigation for wheat can be guaranteed in some drought-prone areas with the quick development of the high-standard construction of farmland in China, but the information about how to better utilize one-off irrigation is limited. Moreover, the interactive effects of irrigation ...
-
Phosphomevalonate Kinase Controls β-Catenin Signaling via the Metabolite 5-DiphosphomevalonateAdvanced Science (IF 17.521) Pub Date : 2023-02-21 ,DOI:10.1002/advs.202204909Zhiqiang Chen, Xinyi Zhou, Xiaojun Zhou, Yi Tang, Mingzhu Lu, Jianhong Zhao, Chenhui Tian, Mingzhi Wu, Yanliang Liu, Edward V. Prochownik, Fubing Wang, Youjun Li
β-catenin signaling is abnormally activated in cancer. Here, this work screens the mevalonate metabolic pathway enzyme PMVK to stabilize β-catenin signaling using a human genome-wide library. On the one hand, PMVK-produced MVA-5PP competitively binds to CKIα to prevent β-catenin Ser45 phosphorylation and degradation. On the other hand, PMVK functions as a protein kinase to directly phosphorylate β-catenin
...
-
p53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppressionCell Death & Disease (IF 9.685) Pub Date : 2023-02-07 ,DOI:10.1038/s41419-023-05625-2Chen, Mingzhu Lu, Genxin Wang, Nagarajan Elumalai, Chenhui Tian, Jinmiao Zhang, Yanliang Liu, Zhiqiang Chen, Xinyi Zhou, Mingzhi Wu, Mengjiao Li, Edward V. Prochownik, Ali Tavassoli, Congqing Jiang, Youjun Li
The metabolic pathways through which p53 functions as a potent tumor suppressor are incompletely understood. Here we report that, by associating with the Vitamin D receptor (VDR), p53 induces numerous genes encoding enzymes for peroxisomal fatty acid β-oxidation (FAO). This leads to increased cytosolic acetyl-CoA levels and acetylation of the enzyme 5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP
...
-
The formation mechanism of landslides in typical fault zones and protective countermeasures: A case study of the Nanpeng River fault zoneFrontiers in Earth Science (IF 3.661) Pub Date : 2023-01-05 ,DOI:10.3389/feart.2022.1092662Youjun Li, Hongri Zhang, Liming Huang, Hongming Li, Xuexiao Wu
Landslides are frequent in the Nanpeng River fault zone in southwest Yunnan. Based on a Zhen Qing Expressway survey, the geological conditions and characteristics of landslides in this area were studied. The conclusions are as follows: 1) the geological background was the internal cause of local highly steep slopes and broken rock masses. The main landslide types in study area are fault-type and accumulation
...
-
Combined Organic Fertilizer and Straw Return Enhanced Summer Maize Productivity and Optimized Soil Nitrate–N distribution in Rainfed Summer Maize–Winter Wheat Rotation on the Southeast Loess PlateauJournal of Soil Science and Plant Nutrition (IF 3.61) Pub Date : 2022-12-22 ,DOI:10.1007/s42729-022-01094-2Kainan Zhao, Ming Huang, Youjun Li, Jinzhi Wu, Wenzhong Tian, Junhong Li, Yuanquan Hou, Shanwei Wu, Jun Zhang, Zhenwang Zhang, Zhiming Zhao, Golam Jalal Ahammed, Guoqiang LiOrganic fertilizer and straw return are sustainable measures for increasing crop yield and improving the soil environment. The present study investigated the effects of combined organic fertilizer and straw return on soil nutrient status, soil nitrate–N distribution, and crop productivity in rainfed maize–wheat rotation on the southeast Loess Plateau. Based on a long-term field fertilization experiment ...
-
Isolation and characterization of avian leukosis virus subgroup J associated with hemangioma and myelocytoma in layer chickens in ChinaFrontiers in Veterinary Science (IF 3.471) Pub Date : 2022-09-23 ,DOI:10.3389/fvets.2022.970818Lan Wu, Youjun Li, Xueyang Chen, Yuxin Yang, Chun Fang, Yufang Gu, Jing Liu, Xiongyan Liang, Yuying Yang
A strain of avian leukosis virus (ALV) belonging to a new envelope subgroup J (ALV-J) emerged in 1988 as a new subgroup of ALV and spread rapidly throughout the world. Due to the infection and spread of ALV-J, the global poultry industry experienced a significant loss. Although the disease had been prevented and controlled effectively by culling domestic chickens in the infected zone, a few field cases
...
-
The longitudinal neural dynamics changes of whole brain connectome during natural recovery from poststroke aphasiaNeuroImage: Clinical (IF 4.891) Pub Date : 2022-09-13 ,DOI:10.1016/j.nicl.2022.103190Liming Fan, Chenxi Li, Zi-gang Huang, Jie Zhao, Xiaofeng Wu, Tian Liu, Youjun Li, Jue Wang
Poststroke aphasia is one of the most dramatic functional deficits that results from direct damage of focal brain regions and dysfunction of large-scale brain networks. The reconstruction of language function depends on the hierarchical whole-brain dynamic reorganization. However, investigations into the longitudinal neural changes of large-scale brain networks for poststroke aphasia remain scarce
...
-
Triple Network Model-Based Analysis on Abnormal Core Brain Functional Network Dynamics in Different Stage of Amnestic Mild Cognitive ImpairmentJournal of Alzheimer’s Disease (IF 4.16) Pub Date : 2022-08-01 ,DOI:10.3233/jad-220282Chenxi Li, Youjun Li, Jianqian Wu, Min Wu, Fang Peng, Qiuling ChaoBackground:Amnestic mild cognitive impairment (aMCI) is considered to be a transitional stage of Alzheimer’s disease (AD) because it has the same clinical symptoms as AD but with lower severity. Studies have confirmed that patients with aMCI are more likely to develop to AD. Although studies on resting state functional connectivity have revealed the abnormal organization of brain networks, the dynamic ...
-
Amyloid-templated polydopamine nanofibers for catecholic immobilization of catalytic noble metal nanoparticlesChemical Communications (IF 6.065) Pub Date : 2022-07-20 ,DOI:10.1039/d2cc02885aLv Lili, Wang Yanwei, You Jun, Li Mingjie, Li ChaoxuDopamine molecules were oxidized and self-polymerized into nanofibers via a template of lysozyme amyloid nanofibrils. The catechol groups adsorbed noble metal ions on the surface of the PDA nanofibers and in situ reduced them into metallic nanoparticles with excellent catalytic activities. This study will not only pave a green way for fabricating 1D nanostructures via biological templates, but also ...
-
P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesisHepatology (IF 17.298) Pub Date : 2022-04-10 ,DOI:10.1002/hep.32518Yahui Zhu, Li Gu, Xi Lin, Xinyi Zhou, Bingjun Lu, Cheng Liu, Yajun Li, Edward V. Prochownik, Michael Karin, Fubing Wang, Youjun LiCholesterol ester (CE) biosynthesis and homeostasis play critical roles in many cancers, including HCC, but their exact mechanistic contributions to HCC disease development require further study. ...
-
Platelet phagocytosis by leukocytes in a patient with cerebral hemorrhage and thrombocytopenia caused by gram-negative bacterial infectionJournal of International Medical Research (IF 1.573) Pub Date : 2022-02-25 ,DOI:10.1177/03000605221079102Xiuji Wu, Youjun Li, Xiaoyang Yang
Bacteria-induced thrombocytopenia is a common clinical disease that is often ignored by clinical and scientific research. Thus, exploring the mechanism and principle of bacteria-induced thrombocytopenia could facilitate the development of new diagnostic, preventative, and treatment modalities for thrombocytopenia. This case report describes a case of platelet phagocytosis by neutrophils and monocytes
...
-
Ecological Protection Technology of Spraying Vegetation Concrete on Carbonaceous Rock Slope Experimental Research and ApplicationAdvances in Civil Engineering (IF 1.843) Pub Date : 2022-02-25 ,DOI:10.1155/2022/2557131Zhenchao Chang, Junhui Luo, Qiongzhen Tang, Ling Zeng, Hongri Zhang, Youjun Li, Gexiao Yang, Liming Zhang
To solve the environmental protection issue of carbonaceous rock slope, the failure mechanism of carbonaceous rock slope and the protection mechanism of vegetation concrete are analyzed based on the engineering characteristics of carbonaceous rock and vegetation concrete. Therefore, the field test of vegetation concrete was carried out to obtain the optimal dosage of vegetation concrete greening additive
...
-
USP19 exacerbates lipogenesis and colorectal carcinogenesis by stabilizing ME1Cell Reports (IF 9.995) Pub Date : 2021-12-28 ,DOI:10.1016/j.celrep.2021.110174Yahui Zhu, Li Gu, Xi Lin, Xinyi Zhou, Bingjun Lu, Cheng Liu, Caoqi Lei, Feng Zhou, Qiu Zhao, Edward V. Prochownik, Youjun Li
Lipogenesis plays a critical role in colorectal carcinogenesis, but precisely how remains unclear. Here, we show that ERK2 phosphorylates ME1 at T103, thereby inhibiting its polyubiquitination and proteasomal degradation and enhancing its interaction with USP19. USP19 antagonizes RNF1-mediated ME1 degradation by deubiquitination, which in turn promotes lipid metabolism and NADPH production and suppresses
...
-
Multiple Sessions of Anodal Transcranial Direct Current Stimulation Over the Right Posterior Parietal Cortex Alleviates Unilateral Spatial NeglectInternational Journal of Psychophysiology (IF 2.903) Pub Date : 2021-10-01 ,DOI:10.1016/j.ijpsycho.2021.07.532Jue Wang,Fangmei He,Youjun Li,Chenxi Li,Tian Liu,Liming Fan
-
Embedding Tangent Space Extreme Learning Machine for EEG Decoding in Brain Computer Interface SystemsJournal of Control Science and Engineering Pub Date : 2021-09-17 ,DOI:10.1155/2021/9959195Mingwei Zhang, Yao Hou, Rongnian Tang, Youjun Li
In motor imagery brain computer interface system, the spatial covariance matrices of EEG signals which carried important discriminative information have been well used to improve the decoding performance of motor imagery. However, the covariance matrices often suffer from the problem of high dimensionality, which leads to a high computational cost and overfitting. These problems directly limit the
...
-
Early Microstructure Changes of White Matter Fiber Bundles in Patients with Amnestic Mild Cognitive Impairment Predicts Progression of Mild Cognitive Impairment to Alzheimer’s DiseaseJournal of Alzheimer’s Disease (IF 4.16) Pub Date : 2021-09-01 ,DOI:10.3233/jad-210495Fangmei He, Yuchen Zhang, Xiaofeng Wu, Youjun Li, Jie Zhao, Peng Fang, Liming Fan, Chenxi Li, Tian Liu, Jue Wang, and Alzheimer’s Disease Neuroimaging InitiativeBackground:Amnestic mild cognitive impairment (aMCI) is the transitional stage between normal aging and Alzheimer’s disease (AD). Some aMCI patients will progress into AD eventually, whereas others will not. If the trajectory of aMCI can be predicted, it would enable early diagnosis and early therapy of AD. Objective:To explore the development trajectory of aMCI patients, we used diffusion tensor imaging ...
-
Propagation Delay Measurement and Evaluation for SV Based on HSR NetworksIEEE Transactions on Industrial Informatics (IF 11.648) Pub Date : 2021-08-19 ,DOI:10.1109/tii.2021.3106238Hualiang Zhou, Yuping Zheng, Jiansong Xu, Youjun Li, Jiaxi CaoRelay protection devices based on sampling and tripping over shared networks, including the switch tree network and high-availability seamless redundancy ring network, have been widely used in smart substations. These networks all have uncertainties in the relay operation system, such as data congestion, delays, errors, and storms, etc., leading errors to sampled value (SV) in digital protection. Therefore ...
-
Repeated anodal high-definition transcranial direct current stimulation over the left dorsolateral prefrontal cortex in mild cognitive impairment patients increased regional homogeneity in multiple brain regions.PLOS ONE (IF 3.752) Pub Date : 2021-08-13 ,DOI:10.1371/journal.pone.0256100Fangmei He,Youjun Li,Chenxi Li,Liming Fan,Tian Liu,Jue Wang
Transcranial direct current stimulation (tDCS) can improve cognitive function. However, it is not clear how high-definition tDCS (HD-tDCS) regulates the cognitive function and its neural mechanism, especially in individuals with mild cognitive impairment (MCI). This study aimed to examine whether HD-tDCS can modulate cognitive function in individuals with MCI and to determine whether the potential
...
-
Changes in the connection network of whole-brain fiber tracts in patients with Alzheimer's disease have a tendency of lateralization.Neuroreport (IF 1.703) Pub Date : 2021-07-30 ,DOI:10.1097/wnr.0000000000001708Fangmei He, Youjun Li, Chenxi Li, Jie Zhao, Tian Liu, Liming Fan, Xi Zhang, Jue WangAlzheimer's disease is a common progressive neurodegenerative disorder in the elderly. Diffusion tensor imaging (DTI) has been widely used to explore structural integrity and to describe white matter degeneration in Alzheimer's disease. Previous research has indicated that the change of connections between white matter fiber tracts is very important for investigating the brain function of Alzheimer's ...
-
MiR-137 inhibits the proliferation, invasion and migration of glioma via targeting to regulate EZH2Genes & Genomics (IF 2.164) Pub Date : 2021-06-23 ,DOI:10.1007/s13258-021-01117-9Jingshun Gu, Juntong Wang, Aiwu You, Jun Li, Yuyan Zhang, Guomin Rao, Xuehua Ge, Kun Zhang, Xuan Liu, Dongchun WangBackground Gliomas are common malignant tumors in the nervous system, known for poor prognosis and low survival rate. Objective This study aims to explore functions of miR-137 in glioma progression and identify messenger RNAs (mRNA) regulated by miR-137, which provides new ideas for further exploration of glioma therapeutic targets. Methods Gene expression data were downloaded from the Cancer Genome ...
-
miR-218-5p inhibits the malignant progression of glioma via targeting TCF12Tumori Journal (IF 2.149) Pub Date : 2021-06-13 ,DOI:10.1177/03008916211018263Jingshun Gu, Xuehua Ge, Aiwu You, Jun Li, Yuyan Zhang, Guomin Rao, Juntong Wang, Kun Zhang, Xuan Liu, Xiaotang Wu, Ling Cheng, Mengjiao Zhu, Dongchun WangSeveral studies have shown the ability of transcription factor 12 (TCF12) to promote tumor malignant progression, but its function in glioma cells has not been fully elucidated. In this study, we analyzed the data from TCGA by bioinformatics and found that in glioma tissue, TCF12 was conspicuously highly expressed while miR-218-5p was significantly low-expressed. The downregulation of miR-218-5p was ...
-
Ceramide-mediated gut dysbiosis enhances cholesterol esterification and promotes colorectal tumorigenesis in miceJCI Insight (IF 9.484) Pub Date : 2021 ,DOI:10.1172/jci.insight.150607Yahui Zhu, Li Gu, Xi Lin, Jinmiao Zhang, Yi Tang, Xinyi Zhou, Bingjun Lu, Xingrong Lin, Cheng Liu, Edward V. Prochownik, Youjun Li
Colorectal cancer (CRC) severely threatens human health and life span. An effective therapeutic strategy has not been established because we do not clearly know its pathogenesis. Here, we report that ceramide and sterol O-acyltransferase 1 (SOAT1) have roles in both spontaneous and chemical-induced intestinal cancers. We first found that miRNA-148a deficiency dramatically increased mouse gut dysbiosis
...
-
Ni-based 3D hierarchical heterostructures achieved by selective electrodeposition as a bifunctional electrocatalyst for overall water splittingElectrochimica Acta (IF 7.336) Pub Date : 2021-02-23 ,DOI:10.1016/j.electacta.2021.138042Youjun Li, Kamran Dastafkan, Qiangqiang Sun, Yi Ma, Xiuhang Wang, Xueying Yang, Zenglin Wang, Chuan ZhaoThe fabrication of efficient, cost-effective and stable bifunctional electrocatalysts for electrocatalytic water splitting is an important way of energy conversion and storage. In this work, ultrathin NiFe alloy layers are coated on the surface and the up-sidewalls of the Ni(Cu) nanotubes by a selective electrodeposition and used as a bifunctional electrocatalyst. Having a 3D honeycomb-like structure ...
-
A switching mechanism of the default-mode network in the brain at criticalityChinese Journal of Physics Pub Date : 2021-02-20 ,DOI:10.1016/j.cjph.2021.02.003Yue Chu, Chen-Ping Zhu, Wen-Tao Zhou, Xiao-Gang Yin, You-Jun Li, Chin-Kun HuMany works confirm the anti-correlations between the default mode network (DMN) and the central-executive network (CEN) in the brain. However, the switching mechanism of the DMN itself is still lack of understanding from the viewpoint of neural network dynamics. Here we simulate the DMN with the Hindmarsh-Rose (HR) neuron model on the small-world network. We model the state of oscillator death and ...
-
FBXL6 degrades phosphorylated p53 to promote tumor growthCell Death and Differentiation (IF 12.067) Pub Date : 2021-02-10 ,DOI:10.1038/s41418-021-00739-6Yajun Li, Kaisa Cui, Qiang Zhang, Xu Li, Xingrong Lin, Yi Tang, Edward V. Prochownik, Youjun LiThe ubiquitin-proteasome system regulates many distinct biological processes. Its dysregulation causes various diseases, including but not limited to cancer. In this study, based on the analysis of gene expression in several colorectal cancer (CRC) datasets, we show that FBXL6, a poorly-characterized F-box protein, is amplified, over-expressed, and highly correlated with poor prognosis in human CRC ...
-
Cooperation effect of indium and vanadium co-doped into bismuth-iron garnets on magnetic propertiesMaterials Research Express (IF 2.025) Pub Date : 2021-01-30 ,DOI:10.1088/2053-1591/abdc54Fan Jiang, Jianghe Lan, Zhantao Wei, Bin You, Jun Li, Yang Li, Deli Shi, Zhengwei Xiong, Pingchuan Zhang, Jinsong Chen
For achieving tunable saturation magnetization and line width, different cations were doped into the YIG-based garnets, which the standard molecular formula could be expressed as A3[Fe2−xMx](Fe3−yNy)O12. Most researchers have reported a single rule of one element doping (x or y) on its magnetic properties. However, the cooperation effect of x+y to the magnetic contribution was not clearly clarified
...
-
The IKKβ-USP30-ACLY Axis Controls Lipogenesis and TumorigenesisHepatology (IF 17.298) Pub Date : 2020-11-06 ,DOI:10.1002/hep.31249Li Gu, Yahui Zhu, Xi Lin, Bingjun Lu, Xinyi Zhou, Feng Zhou, Qiu Zhao, Edward V. Prochownik, Youjun LiHepatocellular carcinoma (HCC) is a leading cause of cancer-related death that develops as a consequence of obesity, cirrhosis and chronic hepatitis. However, the pathways along which these changes occur remain incompletely understood. In this study, we show that the deubiquitinase USP30 is abundant in HCCs that arise in mice maintained on high fat diets (HFDs). IKKβ phosphorylated and stabilized USP30 ...
-
HAS2-AS1 Acts as a Molecular Sponge for miR-137 and Promotes the Invasion and Migration of Glioma Cells by Targeting EZH2Cell Cycle (IF 5.173) Pub Date : 2020-10-16 ,DOI:10.1080/15384101.2020.1826237Juntong Wang, Yuyan Zhang, Aiwu You, Jun Li, Jingshun Gu, Guomin Rao, Xuehua Ge, Kun Zhang, Haoyu Fu, Xiaohui Liu, Jianfeng Li, Qianchao Wang, Xiaotang Wu, Ling Cheng, Mengjiao Zhu, Dongchun WangABSTRACT This study aims to explore the molecular mechanism by which HAS2-AS1 acts as a ceRNA to promote the invasion and migration of glioma cells, which will provide a novel potential target for the targeted therapy of glioma. Gene expression profiles and corresponding clinical data were accessed from the TCGA_LGG and TCGA_GBM databases and then differential analysis was conducted using the “edgeR” ...
-
Investigating the Association between Motor Function, Neuroinflammation, and Recording Metrics in the Performance of Intracortical Microelectrode Implanted in Motor Cortex.Micromachines (IF 3.523) Pub Date : 2020-09-03 ,DOI:10.3390/mi11090838Evon S Ereifej,Youjun Li,Monika Goss-Varley,Youjoung Kim,Seth M Meade,Keying Chen,Jacob Rayyan,He Feng,Keith Dona,Justin McMahon,Dawn Taylor,Jeffrey R Capadona,Jiayang Sun
Long-term reliability of intracortical microelectrodes remains a challenge for increased acceptance and deployment. There are conflicting reports comparing measurements associated with recording quality with postmortem histology, in attempts to better understand failure of intracortical microelectrodes (IMEs). Our group has recently introduced the assessment of motor behavior tasks as another metric
...
-
Cultivation and mulching materials strategies to enhance soil water status, net ecosystem and crop water productivity of winter wheat in semi-humid regionsAgricultural Water Management (IF 6.611) Pub Date : 2020-09-01 ,DOI:10.1016/j.agwat.2020.106240Chunxia Li, Youjun Li, Guozhan Fu, Ming Huang, Chao Ma, Hezheng Wang, Jun ZhangAbstract Different cultivation practices with mulching materials have been applied in the semi-arid areas of China. However, there is still insufficient systematic research on its eff ;ects on ecological indexes and crop water productivity. Therefore, a field trial was carried out in three consecutive study years (2015–2018) to evaluate ecological productivity, crop water productivity, and wheat production ...
广告：喜“文”乐“荐”|邀请好友使用Taylor & Francis Editing Services编辑润色服务，共享专属优惠！推荐人数无限制！
高级搜索
我的搜索条件
京公网安备 11010802027423号