- 作 者: ( "chunjiang he" OR "chun-jiang he" )
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Genome-wide characterization of alternative splicing in blood cells of COVID-19 and respiratory infections of relevanceVirologica Sinica (IF 6.947) Pub Date : 2023-01-20 ,DOI:10.1016/j.virs.2023.01.007Rui Huang, Wenbo Chen, Xueya Zhao, Yuefei Ma, Qiong Zhou, Junsen Chen, Muyi Zhang, Dingran Zhao, Yu Hou, Chunjiang He, Ying Wu
Abstract not available
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Photosynthetic capacity of Erigeron canadensis L. may be more critical to its growth performance than photosynthetic areaBiologia (IF 1.653) Pub Date : 2023-01-17 ,DOI:10.1007/s11756-023-01317-6Chunjiang He, Yue Li, Chuang Li, Yueyang Wang, Zhelun Xu, Shanshan Zhong, Zhongyi Xu, Youli Yu, Daolin Du, Congyan WangLight acquisition and utilization may be vital to the successful invasion of invasive plants. Photosynthetic area and photosynthetic capacity are the two key indicators affecting light acquisition and utilization. Nevertheless, few investigators have verified the contribution intensity of photosynthetic area and photosynthetic capacity of invasive plants to their growth performance in the invaded communities ...
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Prototypical multiple instance learning for predicting lymph node metastasis of breast cancer from whole-slide pathological imagesMedical Image Analysis (IF 13.828) Pub Date : 2023-01-13 ,DOI:10.1016/j.media.2023.102748Jin-Gang Yu, Zihao Wu, Yu Ming, Shule Deng, Yuanqing Li, Caifeng Ou, Chunjiang He, Baiye Wang, Pusheng Zhang, Yu WangComputerized identification of lymph node metastasis of breast cancer (BCLNM) from whole-slide pathological images (WSIs) can largely benefit therapy decision and prognosis analysis. Besides the general challenges of computational pathology, like extra-high resolution, very expensive fine-grained annotation, etc., two particular difficulties with this task lie in (1) modeling the significant inter-tumoral ...
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Large-scale benchmarking of circRNA detection tools reveals large differences in sensitivity but not in precisionbioRxiv - Genomics Pub Date : 2022-12-06 ,DOI:10.1101/2022.12.06.519083Jasper Anckaert, Stefania Bortoluzzi, Alessia Buratin, Chia-Ying Chen, Qinjie Chu, Trees-Juen Chuang, Roozbeh Dehghannasiri, Christoph Dieterich, Xin Dong, Paul Flicek, Enrico Gaffo, Wanjun Gu, Chunjiang He, Steve Hoffmann, Osagie Izuogu, Michael S. Jackson, Tobias Jakobi, Eric C. Lai, Justine Nuytens, Julia Salzman, Mauro Santibanez-Koref, Peter Stadler, Olivier Thas, Eveline Vanden Eynde, Kimberly
The detection of circular RNA molecules (circRNAs) is typically based on short-read RNA sequencing data processed by computational detection tools. During the last decade, a plethora of such tools have been developed, but a systematic comparison is missing. Here, we set up a circRNA detection tool benchmarking study, in which 16 tools were used and detected over 315,000 unique circRNAs in three deeply
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Influence of Platinum on Ablation Behavior of Silicone RubberMaterials Letters (IF 3.574) Pub Date : 2022-09-19 ,DOI:10.1016/j.matlet.2022.133204Chunjiang He, Yuan Ji, Dingfeng PeiThe influence of platinum on silicone rubber ablation was studied by muffle furnace,X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The addition of platinum promoted ceramic formation, causing the silicone compound to burn into a hard ceramic, significantly increasing the residual weight. The XRD showed that the crystallization peak was weakened and the crystal structure was disrupted ...
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circRIP: an accurate tool for identifying circRNA-RBP interactions.Briefings in Bioinformatics (IF 13.994) Pub Date : 2022-07-18 ,DOI:10.1093/bib/bbac186Xin Dong,Ke Chen,Wenbo Chen,Jun Wang,Liuping Chang,Jin Deng,Lei Wei,Leng Han,Chunhua Huang,Chunjiang HeCircular ribonucleic acids (RNAs) (circRNAs) are formed by covalently linking the downstream splice donor and the upstream splice acceptor. One of the most important functions of circRNAs is mainly exerted through binding RNA-binding proteins (RBPs). However, there is no efficient algorithm for identifying genome-wide circRNA-RBP interactions. Here, we developed a unique algorithm, circRIP, for identifying ...
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Circular RNA circYPEL2: A Novel Biomarker in Cervical CancerGenes (IF 4.141) Pub Date : 2021-12-23 ,DOI:10.3390/genes13010038Xinyang Zhang, Siqi Yang, Wenbo Chen, Xin Dong, Rongyu Zhang, Haidong Ye, Xiangfei Mei, Huan Liu, Yu Fang, Chunjiang HeCervical cancer (CC) is one of the most threatening diseases in women. Circular RNAs (circRNAs) have been reported to be cancer hallmarks, but typical circRNAs in CC were rarely indicated. Through high-throughput sequencing in CC and normal cervix tissues, circYPEL2 (hsa_circ_0005600) was proposed as a candidate circRNA. CircYPEL2 exhibited significantly high expression in CC tissue and strong stability ...
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Research on Privacy Data Protection Based on Trusted Computing and BlockchainSecurity and Communication Networks (IF 1.968) Pub Date : 2021-12-17 ,DOI:10.1155/2021/6274860Linkai Zhu, Sheng Peng, Zhiming Cai, Wenjian Liu, Chunjiang He, Weikang Tang
Aiming at the problems of low protection accuracy and long time consumption in traditional privacy data protection methods, a privacy data protection method based on trusted computing and blockchain is proposed. Set up the Internet node secure transmission protocol through the trusted node uplink transmission protocol and the downlink transmission protocol, and according to the transmission protocol
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YTHDF1 promotes mRNA degradation via YTHDF1-AGO2 interaction and phase separationCell Proliferation (IF 8.755) Pub Date : 2021-11-25 ,DOI:10.1111/cpr.13157Jiong Li, Ke Chen, Xin Dong, Yating Xu, Qi Sun, Honghong Wang, Zhen Chen, Cong Liu, Rong Liu, Zhe Yang, Xiangfei Mei, Rongyu Zhang, Liuping Chang, Zongwen Tian, Jianjun Chen, Kaiwei Liang, Chunjiang He, Mengcheng Luo
YTHDF1 is known as a m6A reader protein, and many researches of YTHDF1 focused on the regulation of mRNA translation efficiency. However, YTHDF1 is also related to RNA degradation, but how YTHDF1 regulates mRNA degradation is indefinite. Liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in mammal cells, and there are few reports focused on the correlation of
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The Mathematical Model of Curve-Face Gear and Time-Varying Meshing Characteristics of Compound TransmissionApplied Sciences (IF 2.838) Pub Date : 2021-09-18 ,DOI:10.3390/app11188706Yanan Hu, Chao Lin, Shuo Li, Yongquan Yu, Chunjiang He, Zhiqin Cai
The curve-face gear pair is a new type of gear pair with variable transmission ratio for spatial finite helical motion. In this paper, mathematical models of a new developed curve-face gear were simplified and obtained directly by the standard shaper. The subsequent studies on the curve-face gear compound transmission characteristics were further analyzed by the combinations of the principle of space
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CSCD2: an integrated interactional database of cancer-specific circular RNAsNucleic Acids Research (IF 19.16) Pub Date : 2021-09-09 ,DOI:10.1093/nar/gkab830Jing Feng, Wenbo Chen, Xin Dong, Jun Wang, Xiangfei Mei, Jin Deng, Siqi Yang, Chenjian Zhuo, Xiaoyu Huang, Lin Shao, Rongyu Zhang, Jing Guo, Ronghui Ma, Juan Liu, Feng Li, Ying Wu, Leng Han, Chunjiang He
The significant function of circRNAs in cancer was recognized in recent work, so a well-organized resource is required for characterizing the interactions between circRNAs and other functional molecules (such as microRNA and RNA-binding protein) in cancer. We previously developed cancer-specific circRNA database (CSCD), a comprehensive database for cancer-specific circRNAs, which is widely used in
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Dynamic Optimization of Government Data Transmission Based on Blockchain TechnologyMobile Information Systems (IF 1.863) Pub Date : 2021-07-06 ,DOI:10.1155/2021/8948323Sheng Peng, Linkai Zhu, Zhiming Cai, Wenjian Liu, Chunjiang He, Weikang Tang
With the development of terminal technology and the expansion of application fields, the Internet of Things’ application value and service requirements continue to increase. Efficient data transmission is a reliable guarantee for the development and application of the Internet of Things. Blockchain technology provides a solution for storing and delivering distributed data. On this basis, taking the
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ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissuesBriefings in Bioinformatics (IF 13.994) Pub Date : 2021-06-26 ,DOI:10.1093/bib/bbab274Xuan Liu, Wenbo Chen, Yu Fang, Siqi Yang, Liuping Chang, Xingyu Chen, Haidong Ye, Xinyu Tang, Shan Zhong, Wen Zhang, Zhiqiang Dong, Leng Han, Chunjiang HeGene expression and immune status in human tissues are changed with aging. There is a need to develop a comprehensive platform to explore the dynamics of age-related gene expression and immune profiles across tissues in genome-wide studies. Here, we collected RNA-Seq datasets from GTEx project, containing 16 704 samples from 30 major tissues in six age groups ranging from 20 to 79 years old. Dynamic ...
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Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsyThe FASEB Journal (IF 5.834) Pub Date : 2021-01-08 ,DOI:10.1096/fj.202001737rrLin Shao, Guang‐tong Jiang, Xing‐liang Yang, Meng‐liu Zeng, Jing‐jing Cheng, Shuo Kong, Xin Dong, Tao‐xiang Chen, Song Han, Jun Yin, Wan‐hong Liu, Xiao‐hua He, Chunjiang He, Bi‐wen PengEpilepsy is a common brain disorder, repeated seizures of epilepsy may lead to a series of brain pathological changes such as neuronal or glial damage. However, whether circular RNAs are involved in neuronal injury during epilepsy is not fully understood. Here, we screened circIgf1r in the status epilepticus model through circRNA sequencing, and found that it was upregulated after the status epilepticus ...
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Contact fatigue model and life prediction of compound motion curve-face gear pairTransactions of the Canadian Society for Mechanical Engineering Pub Date : 2020-09-01 ,DOI:10.1139/tcsme-2019-0202Chao Lin, Peilu Li, Chunjiang He, Qingkun XingDifferent from the common face gear pair fixed rotation motion between intersecting axes, the compound transmission of curve-face gear is a new motion form, which can convert rotational motion into... ...
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CircRNA inhibits DNA damage repair by interacting with host gene.Molecular Cancer (IF 41.444) Pub Date : 2020-08-24 ,DOI:10.1186/s12943-020-01246-xXiaolong Xu,Jingwei Zhang,Yihao Tian,Yang Gao,Xin Dong,Wenbo Chen,Xiaoning Yuan,Weinan Yin,Jinjing Xu,Ke Chen,Chunjiang He,Lei Wei
Deregulated circular RNAs (circRNAs) are associated with the development of cancer and therapy resistance. However, functional research of circRNAs mostly focus on potential miRNA or protein binding and more potential regulation of circRNA on host gene DNA in cancers are yet to be inspected. We performed total RNA sequencing on clinical breast cancer samples and identified the expression patterns of
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Breath therapy for patients with chronic nonspecific low back pain: A protocol of systematic review and meta-analysis.Medicine (IF 1.817) Pub Date : 2020-07-31 ,DOI:10.1097/md.0000000000021542Xu He,Chunjiang He,Xiaobing Luo,Huaimin Lu,Liang Wu,Duoduo Yu,Piming Gao,Wenqi Zhou,Hai Shen,Yaming Yu
BACKGROUND Chronic nonspecific low back pain (CNLBP) has become a major global public health problem. Its high incidence rate and high disability rate are so damaging both to individuals and communities. At present, many countries' clinical guidelines recommend exercise therapy. Breath therapy is one of the exercise therapies, playing an important role in exercise therapy. Some studies have shown that
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GR/HDAC2/TGFβR1 pathway contributes to prenatal caffeine induced-osteoarthritis susceptibility in male adult offspring rats.Food and Chemical Toxicology (IF 5.572) Pub Date : 2020-03-19 ,DOI:10.1016/j.fct.2020.111279Jing Li,Hao Xiao,Hanwen Luo,Yang Tan,Qubo Ni,Chunjiang He,Jacques Magdalou,Liaobin Chen,Hui WangPrenatal caffeine exposure (PCE) induces developmental toxicity of multi-organ and susceptibility to multi-disease in offspring. However, the effects of PCE on osteoarthritis susceptibility in adult offspring and its intrauterine programming mechanism remain to be further investigated. Here, we found that PCE induced susceptibility to osteoarthritis in male adult offspring rats, which was related to ...
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Silencing lncRNA SNHG6 suppresses proliferation and invasion of breast cancer cells through miR-26a/VASP axis.Pathology - Research and Practice (IF 3.309) Pub Date : 2019-08-01 ,DOI:10.1016/j.prp.2019.152575Kai Li,Yan-Bin Ma,Yi-Hao Tian,Xiao-Long Xu,Yang Gao,Yan-Qi He,Wen-Ting Pan,Jing-Wei Zhang,Chun-Jiang He,Lei WeiThe important role of LncRNA in the development of breast cancer is attracting more and more attention. In the previous study, we found that the expression level of LncRNA SNHG6 in breast cancer tissues and cells was significantly increased, but its mechanism in the development of breast cancer was still unclear. Our study found that knockdown of SNHG6 significantly inhibited the proliferation, migration ...
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The RNA N6-methyladenosine modification landscape of human fetal tissues.Nature Cell Biology (IF 28.213) Pub Date : 2019-04-29 ,DOI:10.1038/s41556-019-0315-4Shan Xiao,Shuo Cao,Qitao Huang,Linjian Xia,Mingqiang Deng,Mengtian Yang,Guiru Jia,Xiaona Liu,Junfang Shi,Weishi Wang,Yuan Li,Sun Liu,Haoran Zhu,Kaifen Tan,Qizhi Luo,Mei Zhong,Chunjiang He,Laixin XiaA single genome gives rise to diverse tissues through complex epigenomic mechanisms, including N6-methyladenosine (m6A), a widespread RNA modification that is implicated in many biological processes. Here, to explore the global landscape of m6A in human tissues, we generated 21 whole-transcriptome m6A methylomes across major fetal tissues using m6A sequencing. These data reveal dynamic m6A methylation ...
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Genome-wide identification of cancer-specific alternative splicing in circRNA.Molecular Cancer (IF 41.444) Pub Date : 2019-03-10 ,DOI:10.1186/s12943-019-0996-0Jing Feng,Ke Chen,Xin Dong,Xiaolong Xu,Yuxuan Jin,Xinyang Zhang,Wenbo Chen,Yujing Han,Lin Shao,Yang Gao,Chunjiang He
Circular RNA (circRNA) is a group of RNA families generated by RNA circularization, which was discovered ubiquitously across different cancers. However, the internal structure of circRNA is difficult to determine due to alternative splicing that occurs in its exons and introns. Furthermore, cancer-specific alternative splicing of circRNA is less likely to be identified. Here, we proposed a de novo
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The prognostic value of matrix metalloproteinase-7 and matrix metalloproteinase-15 in acute myeloid leukemia.Journal of Cellular Biochemistry (IF 4.48) Pub Date : 2019-02-27 ,DOI:10.1002/jcb.28351Yingjie Wu,Shan Pan,Jun Leng,Tian Xie,Muhammad Jamal,Qian Yin,Jingyuan Li,Chunjiang He,Xin Dong,Liang Shao,Qiuping ZhangMatrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, are involved in a variety of physiological and pathological processes. We analyzed 11 data sets from Gene Expression Omnibus Database and found that MMP7 and MMP15 were highly expressed in multiple carcinomas. GSE13204 showed that MMP7 and MMP15 were overexpressed in acute myeloid leukemia (AML) patients. The Cancer Genome ...
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CVm6A: A Visualization and Exploration Database for m⁶As in Cell Lines.Cells (IF 7.666) Pub Date : 2019-02-17 ,DOI:10.3390/cells8020168Yujing Han,Jing Feng,Linjian Xia,Xin Dong,Xinyang Zhang,Shihan Zhang,Yuqi Miao,Qidi Xu,Shan Xiao,Zhixiang Zuo,Laixin Xia,Chunjiang He
N6-methyladenosine (m⁶A) has been identified in various biological processes and plays important regulatory functions in diverse cells. However, there is still no visualization database for exploring global m⁶A patterns across cell lines. Here we collected all available MeRIP-Seq and m⁶A-CLIP-Seq datasets from public databases and identified 340,950 and 179,201 m⁶A peaks dependent on 23 human and eight
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Loss of miR-146b-5p promotes T cell acute lymphoblastic leukemia migration and invasion via the IL-17A pathway.Journal of Cellular Biochemistry (IF 4.48) Pub Date : 2018-10-25 ,DOI:10.1002/jcb.27882Zhenbo Tu,Jie Xiong,Ruijing Xiao,Liang Shao,Xiangyong Yang,Lu Zhou,Wen Yuan,Meng Wang,Qian Yin,Yingjie Wu,Shan Pan,Jun Leng,Daozi Jiang,Chunjiang He,Qiuping ZhangMetastatic disease remains the primary cause of death for individuals with T cell acute lymphoblastic leukemia (T-ALL). microRNAs (miRNAs) play important roles in the pathogenesis of T-ALL by inhibiting gene expression at posttranscriptional levels. The goal of the current project is to identify any significant miRNAs in T-ALL metastasis. We observed miR-146b-5p to be downregulated in T-ALL patients ...
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Analysis on the kinematical characteristics of compound motion curve-face gear pairMechanism and Machine Theory (IF 4.93) Pub Date : 2018-10-01 ,DOI:10.1016/j.mechmachtheory.2018.06.004Chao Lin, Chunjiang He, Yanan HuAbstract Recently, more and more non-circular gear pairs have been used in gear transmission mechanism. The transmission ratio of some non-circular gear pairs have been presented, however, the relative motions of the two gears are different in different gear pairs. The analytical model and mathematical equations for the classification of the transmission pattern, transmission ratio and relative motions ...
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Tooth contact analysis of elliptical bevel gear with different misalignmentProceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science (IF 1.758) Pub Date : 2018-08-06 ,DOI:10.1177/0954406218791637Chao Lin, Chunjiang HeConsidering the wide use of bevel gear, a new bevel gear type with variable transmission ratio has been proposed. Based on the manufacturing and generating theory of gear, the mathematical equations for the tooth surface of this gear type has been established with two different methods: lead crowning, which meets the commonly used industrial methods with higher efficiency, lower cost and the method ...
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Publisher Correction: miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.Nature Communications (IF 17.694) Pub Date : 2018-04-10 ,DOI:10.1038/ncomms16192Zejuan Li,Hao Huang,Ping Chen,Miao He,Yuanyuan Li,Stephen Arnovitz,Xi Jiang,Chunjiang He,Elizabeth Hyjek,Jun Zhang,Zhiyu Zhang,Abdel Elkahloun,Donglin Cao,Chen Shen,Mark Wunderlich,Yungui Wang,Mary Beth Neilly,Jie Jin,Minjie Wei,Jun Lu,Peter J. M. Valk,Ruud Delwel,Bob Lowenberg,Michelle M. Le Beau,James Vardiman,James C. Mulloy,Nancy J. Zeleznik-Le,Paul P. Liu,Jiwang Zhang,Jianjun Chen
This corrects the article DOI: 10.1038/ncomms1681.
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Kinetic models for the effect of temperature on flavonoid production in liquid submerged fermentation by Phellinus baumii.Biotechnology and Applied Biochemistry (IF 2.724) Pub Date : 2018-03-24 ,DOI:10.1002/bab.1658Fu-Chun Jiang,He-Nan Zhang,Di Wu,Na Feng,Zhong Zhang,Jing-Song Zhang,Jie Feng,Yan YangKinetic models and temperature control strategy were established to reflect the effect of temperature (22 °C-30 °C) on flavonoid production of Phellinus baumii (P. baumii) in 6-L fermentor. A modified Logistic equation, Hinshelwood model, and Luedeking Piret equation were used to describe mycelial growth and product formation. The influence of temperature on the estimated kinetic parameters was further ...
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E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the EGFR and c-MET Oncogenes by Destabilizing the Histone Demethylase KDM5CCancer Research (IF 13.312) Pub Date : 2018-03-15 ,DOI:10.1158/0008-5472.can-17-2118Xiaohua Chen, Jun Xian Loo, Xin Shi, Wenjun Xiong, Yong Guo, Haiqiang Ke, Mingkun Yang, Yanping Jiang, Siyu Xia, Min Zhao, Shan Zhong, Chunjiang He, Li Fu, Feng Li
The high-risk (HR) human papillomaviruses (HPV) are causative agents of anogenital tract dysplasia and cancers and a fraction of head and neck cancers. The HR HPV E6 oncoprotein possesses canonical oncogenic functions, such as p53 degradation and telomerase activation. It is also capable of stimulating expression of several oncogenes, but the molecular mechanism underlying these events is poorly understood
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