- 作 者: ( "lifang fan" OR "li-fang fan" )
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Nickel hexacyanoferrate nanoparticle-decorated 3D rGO composites-based electrochemical sensing platform for detection of di-2-ethylhexyl phthalateMicrochimica Acta (IF 6.408) Pub Date : 2023-02-28 ,DOI:10.1007/s00604-023-05670-wYuyao Liu, Yuan Deng, Dongyun Liao, Yujie Han, Qiang Wang, Yujing Guo, Hongcun Bai, Chuan Dong, Lifang FanA label-free and efficient electrochemical (EC) sensing platform for di-2-ethylhexyl phthalate (DEHP) was developed based on in situ probe nickel hexacyanoferrate nanoparticle (NiHCF NP)-decorated three-dimensional reduced graphene oxide (3D rGO) composites. NiHCF NPs in the composites as an in situ probe show a pair of well-defined peaks with good reversibility and stability. Coupling 3D rGO with ...
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Triple Amplification Ratiometric Electrochemical Aptasensor for CA125 Based on H-Gr/SH-β-CD@PdPtNFsAnalytical Chemistry (IF 8.008) Pub Date : 2022-12-28 ,DOI:10.1021/acs.analchem.2c04161Guojuan Zhang, Yujie Han, Zhiguang Liu, Lifang Fan, Yujing GuoA triple-amplified and ratiometric electrochemical aptasensor for CA125 was designed based on hemin–graphene/SH-β-cyclodextrin@PdPt nanoflower (H-Gr/SH-β-CD@PdPtNF) composites and an exonuclease I (Exo I)-assisted strategy. In the nanocomposite, hemin acts as an internal reference signal owing to the reversible heminox/heminred pair. PdPtNFs can significantly improve the electron transfer rate. SH-β-CD ...
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m5C regulator-mediated modification patterns and tumor microenvironment infiltration characterization in colorectal cancer: One step closer to precision medicineFrontiers in Immunology (IF 8.786) Pub Date : 2022-12-01 ,DOI:10.3389/fimmu.2022.1049435Baoxiang Chen, Yiqing Xi, Jianhong Zhao, Yuntian Hong, Shunhua Tian, Xiang Zhai, Quanjiao Chen, Xianghai Ren, Lifang Fan, Xiaoyu Xie, Congqing Jiang
BackgroundThe RNA modification 5-methylcytosine (m5C) is one of the most prevalent post-transcriptional modifications, with increasing evidence demonstrating its extensive involvement in the tumorigenesis and progression of various cancers. Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer-related deaths worldwide. However, the role of m5C modulators in shaping
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Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatmentAsian Journal of Pharmaceutical Sciences Pub Date : 2022-11-17 ,DOI:10.1016/j.ajps.2022.11.002Yonglong He, Wanting Zhang, Qingqing Xiao, Lifang Fan, Dechun Huang, Wei Chen, Wei He
The liposome is the first nanomedicine transformed into the market and applied to human patients. Since then, such phospholipid bilayer vesicles have undergone technological advancements in delivering small molecular-weight compounds and biological drugs. Numerous investigations about liposome uses were conducted in different treatment fields, including anti-tumor, anti-fungal, anti-bacterial, and
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N6-methyladenosine modification of circ_0003215 suppresses the pentose phosphate pathway and malignancy of colorectal cancer through the miR-663b/DLG4/G6PD axisCell Death & Disease (IF 9.685) Pub Date : 2022-09-20 ,DOI:10.1038/s41419-022-05245-2Baoxiang Chen, Yuntian Hong, Rui Gui, Huabin Zheng, Shunhua Tian, Xiang Zhai, Xiaoyu Xie, Quanjiao Chen, Qun Qian, Xianghai Ren, Lifang Fan, Congqing Jiang
Circular RNAs (circRNAs) are a recently discovered kind of regulatory RNAs that have emerged as critical biomarkers of various types of cancers. Metabolic reprogramming has gradually been identified as a distinct hallmark of cancer cells. The pentose phosphate pathway (PPP) plays an indispensable role in satisfying the bioenergetic and biosynthetic demands of cancer cells. However, little is known
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Design an efficient photoelectrochemical aptasensor for PCB72 based on CdTe@CdS core@shell quantum dots-decorated TiO2 nanotubesJournal of Hazardous Materials (IF 14.224) Pub Date : 2022-09-03 ,DOI:10.1016/j.jhazmat.2022.129901Dongyun Liao, Guifang Liang, Yuyao Liu, Wenjun Yan, Yujing Guo, Wenting Liang, Chuan Dong, Lifang FanIn this work, an efficient and novel photoelectrochemical (PEC) aptasensor for 2,3′,5,5′-tetrachlorobiphenyl (PCB72) was constructed based on CdTe@CdS core@shell quantum dots (CdTe@CdS QDs)-decorated TiO2 nanotubes (TiO2 NTs). CdTe@CdS QDs were prepared by the combination of CdTe and CdS with a proper lattice mismatch. Due to their large band offsets, core@shell QDs can reduce undesirable carrier recombination ...
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Enhanced Effect of Qing-Ying Decoction Concurrent with Secukinumab in the Treatment of Plaque Psoriasis.Alternative therapies in health and medicine Pub Date : 2022-09-01 ,DOI:Zan Tian,Rong Cang,Mingjun Lei,Lifang Fan,Hua Wang,Mengyu Shang,Xiang Li,Fan BaiBoth Qing-Ying decoction (QYD), a Traditional Chinese Medicine (TCM), and secukinumab, a fully humanized anti-interleukin-17A monoclonal antibody, have been used to treat patients with plaque psoriasis. The combined application of TCM and biologics in the treatment of psoriasis, however, has not been investigated. We enrolled a total of 68 patients with plaque psoriasis in our prospective study, and ...
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Media multitasking, depression, and anxiety of college students: Serial mediating effects of attention control and negative information attentional biasFrontiers in Psychiatry (IF 5.435) Pub Date : 2022-08-18 ,DOI:10.3389/fpsyt.2022.989201Shiyi Li, Lifang Fan
Background The COVID-19 epidemic provides an environment for frequent media multitasking, which might associate with an increase in depression and anxiety. Since many studies have found that media multitasking negatively affects cognitive capacity, we propose a cognitive perspective to explore how media multitasking may associate with mental health. This study examined the potential mediating role
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Big Data Technology Oriented to Wetland Resource Ecosystem Value Evaluation.Computational Intelligence and Neuroscience (IF 3.12) Pub Date : 2022-05-30 ,DOI:10.1155/2022/6815102Lifang Fan
In order to study a big data technology research for the evaluation of wetland resource ecosystem value. This paper proposes a wetland dimension oriented to the evaluation of wetland ecosystem services space attribute through big data coupling analysis framework. The framework used China's coastal wetlands as a case for empirical research and summarized the future direction of the research on the value
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A label-free electrochemical aptasensor for the detection of cancer antigen 125 based on nickel hexacyanoferrate nanocubes/polydopamine functionalized grapheneJournal of Electroanalytical Chemistry (IF 4.598) Pub Date : 2022-05-16 ,DOI:10.1016/j.jelechem.2022.116424Fenglin Zhang, Lifang Fan, Zhiguang Liu, Yujie Han, Yujing GuoA highly sensitive label-free electrochemical aptasensor has been proposed to detect ovarian cancer biomarker cancer antigen 125 (CA125) based on nickel hexacyanoferrate (NiHCF) nanocubes as the in-situ signal probe and polydopamine functionalized graphene (PDA@Gr) as substrate. NiHCF is a promising candidate in sensing analysis due to its highly reversible redox ability, good stability and easy synthesis ...
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Liposomal codelivery of inflammation inhibitor and collagen protector to the plaque for effective anti-atherosclerosisChinese Chemical Letters (IF 8.455) Pub Date : 2022-05-02 ,DOI:10.1016/j.cclet.2022.04.081Xiaotong Li, Jiayi Gu, Qingqing Xiao, Ying Liu, Ping Zhou, Lifang Fan, Xiulian Zhang, Xiang Lu, Jun Wu, Zhengxia Liu, Wei HePlaque plays a central role in atherosclerosis (AS) progression, whereas inflammation and destruction of the plaque microenvironment contribute to plaque advancement. As a result, a therapy regime, which combines anti-inflammation and inhibition-degradation of plaque matrix, appears to be a promising strategy to combat AS. Herein, we report a pH-sensitive liposome co-loading with the anti-inflammatory ...
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Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitroChinese Chemical Letters (IF 8.455) Pub Date : 2022-04-23 ,DOI:10.1016/j.cclet.2022.04.051Kosheli Thapa Magar, George Frimpong Boafo, Makhloufi Zoulikha, Xiaohong Jiang, Xiaotong Li, Qingqing Xiao, Xuyang Xing, Xiaochun Wang, Lifang Fan, Zhenfeng Wu, Wei HeMacrophages play a crucial role in initiating, maintaining, and resolving inflammation through the phenotypic shift, inducing or inhibiting the production of inflammatory cytokines. Therefore, macrophages are potential targets for treating inflammatory diseases. Andrographolide (AND) is a potent anti-inflammatory drug that can reduce pro-inflammatory cytokines and suppress NF-κB /MAPK pathway in activated ...
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A selective electrochemical chiral interface based on a carboxymethyl-β-cyclodextrin/Pd@Au nanoparticles/3D reduced graphene oxide nanocomposite for tyrosine enantiomer recognitionAnalyst (IF 5.227) Pub Date : 2022-01-25 ,DOI:10.1039/d1an02262hQingfang Niu, Pengyue Jin, Yu Huang, Lifang Fan, Caihong Zhang, Cheng Yang, Chuan Dong, Wenting Liang, Shaomin ShuangPalladium@gold nanoparticle modified three-dimensional-reduced graphene oxide (3D-rGO/Pd@Au) was coupled with carboxymethyl-β-cyclodextrin to form a novel nanocomposite (3D-rGO/Pd@Au/CM-β-CD). The 3D-rGO/Pd@Au/CM-β-CD served as a chiral sensing interface for the electrochemical enantiorecognition of tyrosine (Tyr) via a differential pulse voltammetry (DPV) approach. The 3D-rGO/Pd@Au demonstrates good ...
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Highly sensitive and selective photoelectrochemical aptasensing of di-2-ethylhexyl phthalate based on graphene quantum dots decorated TiO2 nanotube arraysJournal of Hazardous Materials (IF 14.224) Pub Date : 2021-12-18 ,DOI:10.1016/j.jhazmat.2021.128107Yuan Deng, Wenjun Yan, Yujing Guo, Qiang Wang, Yingpu Bi, Chuan Dong, Lifang FanA photoelectrochemical (PEC) sensing platform for di-2-ethylhexyl phthalate (DEHP) was constructed using graphene quantum dots decorated TiO2 nanotube arrays (GQDs-decorated TiO2 NTs) as the transducer species and the anti-DEHP aptamer as the biological recognition element. GQDs were synthesized using the alkali-mediated hydrothermal method, and then anchored onto the TiO2 NTs uniformly and intimately ...
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Effects of modified BOPPPS-based SPOC and Flipped class on 5th-year undergraduate oral histopathology learning in China during COVID-19BMC Medical Education (IF 3.263) Pub Date : 2021-10-26 ,DOI:10.1186/s12909-021-02980-6Wang, Shan, Xu, Xin, Li, Fang, Fan, Haixia, Zhao, Eryang, Bai, Jie
Colleges and universities in China have offered courses based on online teaching platforms as required by the Ministry of Education since the beginning of the COVID-19 pandemic. This emergency action was not an expedient measure, but a powerful impetus to improve extant education and implement teaching reform. Oral histopathology is a basic subject in oral medicine education, which combines theory
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Sleep Reactivity and Depressive Symptoms Among Chinese Female Student Nurses: A Longitudinal Mediation AnalysisFrontiers in Psychiatry (IF 5.435) Pub Date : 2021-09-29 ,DOI:10.3389/fpsyt.2021.748064Xuliang Shi, Haiying Qi, Shuo Wang, Zihan Li, Zhipeng Li, Fang Fan
Previous cross-sectional studies have documented that sleep reactivity was associated with depressive symptoms, but the potential mechanisms underlying this relationship were understudied. Therefore, the present study with a longitudinal prospective design was to reveal the mediating roles of sleep disturbance and emotion regulation difficulties (ERD) between sleep reactivity and depressive symptoms
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Gene Expression Profiling for Differential Diagnosis of Liver Metastases: A Multicenter, Retrospective Cohort StudyFrontiers in Oncology (IF 5.738) Pub Date : 2021-09-22 ,DOI:10.3389/fonc.2021.725988Qifeng Wang, Fen Li, Qingming Jiang, Yifeng Sun, Qiong Liao, Huimin An, Yunzhu Li, Zhenyu Li, Lifang Fan, Fang Guo, Qinghua Xu, Yixin Wo, Wanli Ren, Junqiu Yue, Bin Meng, Weiping Liu, Xiaoyan Zhou
Background Liver metastases (LM) are the most common tumors encountered in the liver and continue to be a significant cause of morbidity and mortality. Identification of the primary tumor of any LM is crucial for the implementation of effective and tailored treatment approaches, which still represents a difficult problem in clinical practice. Methods The resection or biopsy specimens and associated
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Sandwich electrochemical carcinoembryonic antigen aptasensor based on signal amplification of polydopamine functionalized graphene conjugate Pd-Pt nanodendritesBioelectrochemistry (IF 5.76) Pub Date : 2021-08-31 ,DOI:10.1016/j.bioelechem.2021.107947Fenglin Zhang, Zhiguang Liu, Yujie Han, Lifang Fan, Yujing GuoCarcinoembryonic antigen (CEA) is considered as a disease biomarker, which is related to various cancers and tumors in the human bodies. Sensitive detection of CEA is significant for clinical diagnosis and treatment. Herein, we proposed an electrochemical aptasensor for CEA detection based on the amplification driven by polydopamine functional graphene and Pd-Pt nanodendrites (PDA@Gr/Pd-PtNDs), conjugated ...
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EDTA-β-cyclodextrin functionalized graphene for electrochemical detection and scavenge of DPPH radicalJournal of Applied Electrochemistry (IF 2.384) Pub Date : 2021-07-19 ,DOI:10.1007/s10800-021-01598-2Yu Zuo, Yujie Han, Guojuan Zhang, Lifang Fan, Zhiguang Liu, Yujing GuoAbstract In this work, a novel and robust electrochemical sensor was developed by modifying EDTA and β-cyclodextrin functionalized reduced graphene oxide (EDTA-β-CD-rGO) onto the Glassy carbon electrodes (GCE) to quantify 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH). The morphology and structures of the nanocomposite were characterized by the UV–vis spectroscopy, Fourier transform infrared (FT-IR) ...
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Electrochemical aptasensor for sensitive detection of Cardiac troponin I based on CuNWs/MoS2/rGO nanocompositeMicrochemical Journal (IF 5.304) Pub Date : 2021-07-03 ,DOI:10.1016/j.microc.2021.106598Yujie Han, Xujie Su, Lifang Fan, Zhiguang Liu, Yujing GuoCardiac troponin I (cTnI) is a “gold standard biomarker” for clinical diagnose of acute myocardial infarction (AMI). Rapid, accurate, and sensitive detection methods for cTnI are highly urgent and significant in early diagnosis and progression control. In this work, we proposed an electrochemical aptasensing platform for cTnI detection based on copper nanowires/molybdenum disulfide/reduced graphene ...
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A highly sensitive photoelectrochemical aptasensor based on BiVO4 nanoparticles-TiO2 nanotubes for detection of PCB72Talanta (IF 6.556) Pub Date : 2021-05-26 ,DOI:10.1016/j.talanta.2021.122551Lifang Fan, Guifang Liang, Wenjun Yan, Yujing Guo, Yingpu Bi, Chuan DongIn this work, a simple and highly sensitive photoelectrochemical (PEC) aptasensor has been developed for detecting PCB72 based on TiO2 nanotubes (NTs) decorated with BiVO4 nanoparticles (NPs). The BiVO4 NPs-TiO2 NTs composites prepared through a simple hydrothermal method exhibit good visible-light adsorption ability, high PEC response and perfect photo-excited stability. The synthesized composites ...
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Lipid Droplet-Specific Fluorescent Probe for In Vivo Visualization of Polarity in Fatty Liver, Inflammation, and Cancer ModelsAnalytical Chemistry (IF 8.008) Pub Date : 2021-05-26 ,DOI:10.1021/acs.analchem.1c01125Li Fan, Xiaodong Wang, Qi Zan, Lifang Fan, Feng Li, Yongming Yang, Caihong Zhang, Shaomin Shuang, Chuan DongElucidating the intrinsic relationship between diseases and lipid droplet (LD) polarity remains a great challenge owing to the lack of the research on multiple disease models. Until now, the visualization of abnormal LD polarity in models of inflammation and clinical cancer patient samples has not been achieved. To meet the urgent challenge, we facilely synthesized a robust LD-specific and polarity-sensitive ...
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Delivery strategies of amphotericin B for invasive fungal infectionsActa Pharmaceutica Sinica B (IF 14.903) Pub Date : 2021-04-29 ,DOI:10.1016/j.apsb.2021.04.010Xiaochun Wang, Imran Shair Mohammad, Lifang Fan, Zongmin Zhao, Md Nurunnabi, Marwa A. Sallam, Jun Wu, Zhongjian Chen, Lifang Yin, Wei He
Invasive fungal infections (IFIs) represent a growing public concern for clinicians to manage in many medical settings, with substantial associated morbidities and mortalities. Among many current therapeutic options for the treatment of IFIs, amphotericin B (AmB) is the most frequently used drug. AmB is considered as a first-line drug in the clinic that has strong antifungal activity and less resistance
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Ti3C2 MXenes with intrinsic peroxidase-like activity for label-free and colorimetric sensing of proteinsMicrochemical Journal (IF 5.304) Pub Date : 2021-04-05 ,DOI:10.1016/j.microc.2021.106238Miaomiao Li, Xiuying Peng, Yujie Han, Lifang Fan, Zhiguang Liu, Yujing GuoMXenes are attractive for various biosensors owning to their tunable versatile properties. Herein, Ti3C2 nanosheets (Ti3C2 NSs) were found to possess intrinsic peroxidase-like activity, and which could be enhanced by single-stranded DNA (ssDNA) adsorbed on the nanosheets. Hence, a simple label-free sensing strategy was developed for colorimetric detection of biomolecules, based on Ti3C2 NSs as a peroxidase ...
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Highly sensitive photoelectrochemical aptasensor based on MoS2 quantum dots/TiO2 nanotubes for detection of atrazineSensors and Actuators B: Chemical (IF 9.221) Pub Date : 2021-02-14 ,DOI:10.1016/j.snb.2021.129652Lifang Fan, Caiyun Zhang, Guifang Liang, Wenjun Yan, Yujing Guo, Yingpu Bi, Chuan DongDue to the potential hazards of atrazine, developing efficient and accurate detection methods in the environment is urgently needed. In this work, a simple and highly sensitive photoelectrochemical (PEC) aptasensor was constructed for detection of atrazine by exploring TiO2 nanotubes decorated with MoS2 quantum dots (MoS2 QDs/TiO2 NTs) as the photoelectrode and aptamer molecules as the recognition ...
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[Determination of domoic acid in shellfish by liquid chromatography- tandem mass spectrometry coupled with dispersive solid phase extraction].Wei sheng yan jiu = Journal of hygiene research Pub Date : 2021-01-01 ,DOI:10.19813/j.cnki.weishengyanjiu.2021.01.020Li Fang,Fan Wu,Fengmei Qiu,Xinwei Yu,Yanhua ZhuOBJECTIVE A method utilizing liquid chromatography-tandem mass spectrometry(LC-MS/MS) coupled with dispersive solid phase extraction for quantitative analysis of domoic acid in four kinds of shellfish was established. METHODS The sample of 0. 1 g was extracted with 25% methanol aqueous solution, the extract was purified by dispersive solid phase extraction with 50 mg HLB and 5 mg GCB, and then filtered ...
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Visible-light-driven photoelectrochemical sensing platform based on BiOI nanoflowers/TiO2 nanotubes for detection of atrazine in environmental samplesJournal of Hazardous Materials (IF 14.224) Pub Date : 2020-12-18 ,DOI:10.1016/j.jhazmat.2020.124894Lifang Fan, Guifang Liang, Caiyun Zhang, Li Fan, Wenjun Yan, Yujing Guo, Shaomin Shuang, Yingpu Bi, Feng Li, Chuan DongIn this work, a visible-light-driven photoelectrochemical (PEC) sensing platform was developed based on BiOI nanoflowers/TiO2 nanotubes (BiOI NFs/TiO2 NTs) for detection of atrazine (ATZ). The BiOI NFs/TiO2 NTs p–n heterojunctions synthesized by decorating BiOI NFs on TiO2 NTs via simple hydrothermal approach exhibit strong visible-light absorption ability, high photocurrent response and PEC activity ...
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A novel dual signal and label-free electrochemical aptasensor for mucin 1 based on hemin/graphene@PdPtNPsBiosensors and Bioelectronics (IF 12.545) Pub Date : 2020-11-04 ,DOI:10.1016/j.bios.2020.112785Guojuan Zhang, Zhiguang Liu, Lifang Fan, Yujie Han, Yujing GuoA dual signal and label-free electrochemical aptasensor for mucin 1 was constructed based on hemin/graphene@PdPtNPs nanocomposite (H-Gr@PdPtNPs). Hemin attached on the graphene surface not only improves the solubility of graphene and acts as an in-situ electrochemical probe but also exhibits excellent peroxidase-like properties to electrocatalyze the reduction of H2O2. PdPtNPs also show outstanding ...
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Seizures and risk of epilepsy in anti-NMDAR, anti-LGI1, and anti-GABAB R encephalitis.Annals of Clinical and Translational Neurology (IF 5.43) Pub Date : 2020-07-25 ,DOI:10.1002/acn3.51137Chun-Hong Shen,Gao-Li Fang,Fan Yang,Meng-Ting Cai,Yang Zheng,Wei Fang,Yi Guo,Yin-Xi Zhang,Mei-Ping Ding
Accumulating data have suggested seizures occur frequently in patients with neuronal surface antibody‐mediated autoimmune encephalitis. We aimed to evaluate seizure outcomes and potential factors associated with the development of epilepsy in patients with anti‐N‐methyl‐D‐aspartate receptor (NMDAR), anti‐leucine‐rich glioma‐inactivated 1 (LGI1), and anti‐gamma‐aminobutyric‐acid B receptor (GABABR)
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