- 作 者: ( "xiaoqing liu" OR "xiao-qing liu" )
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Comparative transcriptome analysis provides insights into the TDG supersaturation stress response of Schizothorax davidiComparative Biochemistry and Physiology C: Toxicology & Pharmacology (IF 4.52) Pub Date : 2023-03-31 ,DOI:10.1016/j.cbpc.2023.109618Yeyu Chen, Xiaoyun Wu, Xiaoqing Liu, Jiansheng Lai, Quan GongIn the dam discharge season, the supersaturation of total dissolved gas (TDG) in the downstream channel can seriously affect the survival of aquatic organisms. However, few studies have revealed the mechanism by which TDG supersaturation affects the physiology of fish thus far. The present study was conducted to study the mechanism of the effect of TDG supersaturation on Schizothorax davidi, a species ...
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Regulating T-cell metabolic reprogramming and blocking PD-1 co-promote personalized postoperative autologous nanovaccinesBiomaterials (IF 15.304) Pub Date : 2023-03-31 ,DOI:10.1016/j.biomaterials.2023.122104Lili Chang, Shunli Fu, Tong Gao, Xiao Sang, Han Yang, Xiaoqing Liu, Huizhen Yang, Yongjun Liu, Na ZhangCytotoxic T lymphocytes (CTLs) are central effector cells in antitumor immunotherapy. However, the complexity of immunosuppressive factors in the immune system contributes to the low response rates of current CTL-based immunotherapies. Here, we propose a novel holistic strategy including a priming response, promoting activity, and relieving suppression of CTL, aiming to strengthen the effect of personalized ...
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Biobased Epoxy Resin with Inherently Deep-UV Photodegradability for a Positive Photoresist and AnticounterfeitingACS Applied Polymer Materials (IF 4.855) Pub Date : 2023-03-29 ,DOI:10.1021/acsapm.3c00291Dandan Jin, Jinyue Dai, Weiwei Zhao, Xiaoqing LiuBiobased epoxy resins have received widespread attention due to their substitution for petroleum-based ones in conventional fields but are rarely reported in functional materials. Herein, a biobased epoxy resin with inherently deep-UV photodegradability was reported. The strategy was based on the [2 + 2] photocycloaddition of trans-cinnamic acid, a renewable resource, to generate a cyclobutane structure ...
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High Production of Maltooligosaccharides in the Starch Liquefaction Process: A Study on the Hyperthermophilic Mechanism of α-AmylaseJournal of Agricultural and Food Chemistry (IF 5.895) Pub Date : 2023-03-23 ,DOI:10.1021/acs.jafc.3c00665Min Liao, Ruyue Dong, Lanxue Li, Xiaoqing Liu, Yaru Wang, Yingguo Bai, Huiying Luo, Bin Yao, Huoqing Huang, Tao TuThe efficient production of high-value-added bioproducts from starchy substances requires α-amylases with hyperthermophilic properties for industrial starch liquefaction. In this study, two hyperthermophilic α-amylases with significant differences in thermostability, PfAmy and TeAmy, were comparatively studied through structural analysis, domain swapping, and site-directed mutagenesis, finding that ...
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A glutamatergic DRN-VTA pathway for neuropathic pain and comorbid depression-like behavior modulationbioRxiv - Neuroscience Pub Date : 2023-03-23 ,DOI:10.1101/2023.03.22.532931xinyue wang, wenbin jia, xiang xu, rei chen, liangbiao wang, xiaojing su, pengfei xu, xiaoqing liu, jie wen, yuanyuan liu, xinfeng liu, zhi zhang, Yan Zhang
Chronic pain causes both physical suffering and comorbid mental disorders such as depression. However, the neural circuits and molecular mechanisms underlying these maladaptive behaviors remain elusive. Here, we report a pathway from vesicular glutamate transporter3 neurons in the dorsal raphe nucleus to dopamine neurons in the ventral tegmental area (VGluT3DRN→DAVTA), of which population activity
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Correction: Ye et al. Evaluation of the Brewing Characteristics, Digestion Profiles, and Neuroprotective Effects of Two Typical Se-Enriched Green Teas. Foods 2022, 11, 2159Foods (IF 5.561) Pub Date : 2023-03-22 ,DOI:10.3390/foods12061339Yuanyuan Ye, Jiangling He, Zhijun He, Na Zhang, Xiaoqing Liu, Jiaojiao Zhou, Shuiyuan Cheng, Jie Cai
The authors wish to make the following corrections to their published paper [...]
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Tailoring Anion Association Strength Through Polycation-Anion Coordination Mechanism in Imidazole Polymeric Ionic Liquid-Based Artificial Interphase toward Durable Zn Metal AnodesAdvanced Functional Materials (IF 19.924) Pub Date : 2023-03-16 ,DOI:10.1002/adfm.202301129Jiaqi Ke, Zhipeng Wen, Yang Yang, Rong Tang, Yongchao Tang, Minghui Ye, Xiaoqing Liu, Yufei Zhang, Cheng Chao LiArtificial interface layer engineering is an efficacious modification strategy for protecting zinc anode from dendrite growth and byproducts formation. However, the high bulk ionic conductivity of most artificial interfacial layers is mainly contributed by the movement of anions (SO42−), which is the source of parasitic reactions on zinc anode. Herein, a high zinc ion donor transition (σZn2+ = 3.89 ...
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Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccineSignal Transduction and Targeted Therapy (IF 38.104) Pub Date : 2023-03-15 ,DOI:10.1038/s41392-023-01345-3Shaofu Qiu, Zhao Chen, Airu Zhu, Qiuhui Zeng, Hongbo Liu, Xiaoqing Liu, Feng Ye, Yingkang Jin, Jie Wu, Chaojie Yang, Qi Wang, Fangli Chen, Lan Chen, Sai Tian, Xinying Du, Qingtao Hu, Jinling Cheng, Canjie Chen, Fang Li, Jing Sun, Yanqun Wang, Jingxian Zhao, Jincun Zhao, Hongbin Song
Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular
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Ferroptosis, pyroptosis and necroptosis in acute respiratory distress syndromeCell Death Discovery (IF 7.109) Pub Date : 2023-03-10 ,DOI:10.1038/s41420-023-01369-2Yongxin Zheng, Yongbo Huang, Yonghao Xu, Ling Sang, Xiaoqing Liu, Yimin Li
Acute respiratory distress syndrome (ARDS) is an acute and uncontrolled pulmonary inflammation caused by various insults. Cell death is a critical mechanism in the pathogenesis of ARDS. Ferroptosis, a novel form of cell death defined as iron-mediated lipid peroxidation, has been shown to play a role in the pathogenesis of ARDS. Additionally, pyroptosis and necroptosis are also involved in the pathophysiological
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Cadmium-absorptive Bacillus vietnamensis 151-6 reduces the grain cadmium accumulation in rice (Oryza sativa L.): Potential for cadmium bioremediation.Ecotoxicology and Environmental Safety (IF 7.129) Pub Date : 2023-03-10 ,DOI:10.1016/j.ecoenv.2023.114760Xiaoxia Yu,JinTong Zhao,Zundan Ding,Feng Xiong,Xiaoqing Liu,Jian Tian,Ningfeng WuMicrobial bioremediation of heavy metal-polluted soil is a promising technique for reducing heavy metal accumulation in crops. In a previous study, we isolated Bacillus vietnamensis strain 151-6 with a high cadmium (Cd) accumulation ability and low Cd resistance. However, the key gene responsible for the Cd absorption and bioremediation potential of this strain remains unclear. In this study, genes ...
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The thalamic reticular nucleus-lateral habenula circuit regulates depressive-like behaviors in chronic stress and chronic painbioRxiv - Neuroscience Pub Date : 2023-03-09 ,DOI:10.1101/2023.02.17.528253Xiang Xu, Rui Chen, Xin-Yue Wang, Wen-Bin Jia, Peng-Fei Xu, Xiao-Qing Liu, Ying Zhang, Xin-Feng Liu, Yan Zhang
Chronic stress and chronic pain are two major predisposing factors to trigger depression. Enhanced excitatory input to the lateral habenula (LHb) has been implicated in pathophysiology of depression. However, the contribution of inhibitory transmission remains elusive. Here, we dissect an inhibitory projection from sensory thalamic reticular nucleus (sTRN) to LHb, which is activated by acute aversive
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Regulation of Ionic Distribution and Desolvation Activation Energy Enabled by In Situ Zinc Phosphate Protective Layer toward Highly Reversible Zinc Metal AnodesAdvanced Functional Materials (IF 19.924) Pub Date : 2023-03-05 ,DOI:10.1002/adfm.202208230Shengzhao Zhang, Minghui Ye, Yufei Zhang, Yongchao Tang, Xiaoqing Liu, Cheng Chao LiDespite the merits of high specific capacity, low cost, and high safety, the practical application of aqueous Zn metal batteries (AZMBs) is plagued by the dendritic growth and corrosion reaction of Zn metal anodes. To solve these issues, a Zn3(PO4)2·4H2O protective layer is in-situ constructed on Zn foil (Zn@ZnPO) by a simple hydrothermal method, avoiding the traditional slurry-casting process. The ...
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Structural Phase Transition of Quinone-Containing PAH Derivatives on Au(111) at High CoverageThe Journal of Physical Chemistry C (IF 4.177) Pub Date : 2023-03-03 ,DOI:10.1021/acs.jpcc.2c08811Xin Song, Zhicun Zhou, Xinchen Peng, Xinbang Liu, Dianrong Han, Hang Zhang, Xiaoqing Liu, Li Wang, Huihui KongDelicate control over structural phase transition provides advanced approaches for the fabrication of the desired well-ordered nanoarchitectures on surfaces. The participation of intrinsic metal adatoms in pure organic systems can facilitate the structural phase transition by direct capture of surface metal adatoms and forming metal–organic bonds. However, most of the situations occur at low coverage; ...
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Age and Genetic Risk Score and Rates of Blood Lipid Changes in China.JAMA Network Open (IF 13.353) Pub Date : 2023-03-01 ,DOI:10.1001/jamanetworkopen.2023.5565Jianxin Li,Mengyao Liu,Fangchao Liu,Shufeng Chen,Keyong Huang,Jie Cao,Chong Shen,Xiaoqing Liu,Ling Yu,Yingxin Zhao,Huan Zhang,Shujun Gu,Liancheng Zhao,Ying Li,Dongsheng Hu,Jianfeng Huang,Dongfeng Gu,Xiangfeng Lu
Importance Blood lipids are the primary cause of atherosclerosis. However, little is known about relationships between rates of blood lipid changes and age and genetic risk. Objective To evaluate associations of blood lipid change rates with age and polygenic risk. Design, Setting, and Participants This cohort is from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China, which was
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Fluorine-regulated carbon nanotubes decorated with Co single atoms for multi-site electrocatalysis toward two-electron oxygen reductionEcoMat (IF 12.213) Pub Date : 2023-02-28 ,DOI:10.1002/eom2.12336Yunrui Tian, Rui Chen, Xiaoqing Liu, Lichang Yin, De'an Yang, Feng Hou, Ji Liang
Producing hydrogen peroxide (H2O2) via a two-electron oxygen reduction reaction (2 e−-ORR) is a promising alternative to the conventional anthraquinone process, because of its exceptional low-risk and distributed features. The low yield of H2O2 on typical electrocatalysts, usually associated with limited and vulnerable catalytically active sites on their surface, has been the major restriction for
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Non-fused Polymerized Small-Molecule Acceptors with a Benzothiadiazole Core for All-Polymer Solar CellsACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2023-02-28 ,DOI:10.1021/acsami.2c21574Chao Wang, Jie Fang, Chong Guan, Ting Wu, Xiaoqing Liu, Feng Liu, Chengyi Xiao, Weiwei LiPolymerized small-molecule acceptors (PSMAs) have made significant progress as the application in all-polymer solar cells (all-PSCs). Most PSMAs are constructed by near-infrared fused-ring electron acceptors via Stille polymerization, such as Y-series acceptors. However, very limited non-fused electron acceptors with simplified synthetic complexity have been used in PSMAs. In this work, two non-fused ...
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Synthesis of biologically active [1,5]diazocino[2,1-b]quinazolinones through [4 + 4] cycloaddition of 2-alkynyl quinazolinones with aza-ortho-quinone methidesOrganic Chemistry Frontiers (IF 5.456) Pub Date : 2023-02-28 ,DOI:10.1039/d3qo00056gLi Pang, Shu-Jun Fang, Pei-Sen Zou, Wang Wang, Jun-Cheng Su, Xiao-Qing Liu, Cheng-Xue Pan, Dong-Liang Mo, Gui-Fa SuWe report an atom-economical [4 + 4] cycloaddition of 2-alkynyl quinazolines with aza-ortho-quinone methides (ao-QMs) generated from 2-(bromomethyl)anilines to prepare various [1,5]diazocino[2,1-b]quinazolinones in good to excellent yields in a short reaction time and under mild reaction conditions. Moreover, an estrone-derived [1,5]diazocino[2,1-b]quinazolinone could be easily prepared in 30% total ...
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Cytomegalovirus antigen-specific T cell immune responses in patients with autoimmune diseases under different cytomegalovirus infection status.Chinese medical journal Pub Date : 2023-02-28 ,DOI:10.1097/cm9.0000000000002452Yuting Tan,Huimin Ma,Xiaoqing Liu,Xiaochun Shi,Wenjie Zheng,Jingtao Cui,Lifan Zhang,Yaling Dou,Baotong Zhou
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Combining manipulation of integration loci and secretory pathway on expression of an Aspergillus niger glucose oxidase gene in Trichoderma reeseiMicrobial Cell Factories (IF 6.352) Pub Date : 2023-02-25 ,DOI:10.1186/s12934-023-02046-wWangli Ji, Xiaolu Wang, Xiaoqing Liu, Yuan Wang, Fangui Liu, Bo Xu, Huiying Luo, Tao Tu, Wei Zhang, Xinxin Xu, Xiaoyun Su
Trichoderma reesei (T. reesei) is well-known for its excellent ability to secret a large quantity of cellulase. However, unlike the endogenous proteins, little is known about the molecular mechanisms governing heterologous protein production. Herein, we focused on the integration loci and the secretory pathway, and investigated their combinatorial effects on heterologous gene expression in T. reesei
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[Effect of a novel phosphodiesterase 5 inhibitor, CPD1, on renal interstitial fibrosis after unilateral renal ischemia-reperfusion injury].Sheng li xue bao : [Acta physiologica Sinica] Pub Date : 2023-02-25 ,DOI:Ao-Lu Liu,Zhuang Li,Mei-Zhi Lu,Hao-Heng Qiu,Zhong-Lian Xie,Xiao-Qing Liu,Allan Zi-Jian Zhao,Yun-Ping Mu,Fang-Hong LiThis study was designed to evaluate the protective effect of CPD1, a novel phosphodiesterase 5 inhibitor, on renal interstitial fibrosis after unilateral renal ischemia-reperfusion injury (UIRI). Male BALB/c mice were subjected to UIRI, and treated with CPD1 once daily (i.g, 5 mg/kg). Contralateral nephrectomy was performed on day 10 after UIRI, and the UIRI kidneys were harvested on day 11. Hematoxylin-eosin ...
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Genome-Wide Analysis of the Rhododendron AP2/ERF Gene Family: Identification and Expression Profiles in Response to Cold, Salt and Drought Stress.Plants (IF 4.658) Pub Date : 2023-02-22 ,DOI:10.3390/plants12050994Zhenhao Guo,Lisi He,Xiaobo Sun,Chang Li,Jiale Su,Huimin Zhou,Xiaoqing Liu
The AP2/ERF gene family is one of the most conserved and important transcription factor families mainly occurring in plants with various functions in regulating plant biological and physiological processes. However, little comprehensive research has been conducted on the AP2/ERF gene family in Rhododendron (specifically, Rhododendron simsii), an important ornamental plant. The existing whole-genome
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Hydrated Eutectic Electrolytes Stabilizing Quasi-Underpotential Mg Plating/Stripping for High-Voltage Mg BatteriesAngewandte Chemie International Edition (IF 16.823) Pub Date : 2023-02-14 ,DOI:10.1002/anie.202217945Guigui Liu, Yongchao Tang, Hongqing Li, Jiangfeng He, Minghui Ye, Yufei Zhang, Zhipeng Wen, Xiaoqing Liu, Cheng Chao LiA stable quasi-underpotential Mg stripping/plating chemistry (UPMC) on Zn substrate is initially achieved in new adiponitrile-based hydrated eutectic electrolytes (HEEs), realizing ultralow UPMC overpotentials and high energy/voltage plateau of aqueous rechargeable Mg batteries. ...
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Highly birefringent one-air-hole panda fiberOptics Letters (IF 3.56) Pub Date : 2023-02-10 ,DOI:10.1364/ol.482214Wa Jin, Xiang Zhang, and Xiao Qing LiuThis Letter proposes a highly birefringent one-air-hole panda fiber, which is fabricated by corroding a single stress zone of the traditional panda-type polarization-maintaining fiber (PMF). An additional geometric asymmetry is induced in the fiber to increase the birefringence effect and enhance the light–matter interaction, which improves the performance of the sensor and the device applications ...
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Recovery of host adaptive immune function promoted the reduction of hepatitis B surface antigen in nucleoside analog-experienced chronic hepatitis B patients with low hepatitis B surface antigen levelsCytokine (IF 3.926) Pub Date : 2023-02-03 ,DOI:10.1016/j.cyto.2023.156140Qian Zhang, Xiaoqing Liu, Xicheng Pang, Huimin Wang, Jinjie Du, Hong Ren, Peng HuHepatitis B surface antigen (HBsAg) seroclearance is an optimal therapeutic endpoint, as it reflects the amount of covalently closed circular DNA. The exact mechanisms that contribute to HBsAg reduction are not completely understood. We evaluated adaptive immunity in nucleoside analog-experienced chronic hepatitis B (CHB) patients with low HBsAg levels who received oral antiviral therapy. One hundred ...
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The low-k epoxy/cyanate nanocomposite modified with epoxy-based POSS: The effect of microstructure on dielectric propertiesReactive & Functional Polymers (IF 4.966) Pub Date : 2023-02-03 ,DOI:10.1016/j.reactfunctpolym.2023.105522Xiaodan Li, Xiaoqing Liu, Hongyu Liu, Rui He, Feng Wang, Shiyun Meng, Zhaomin LiEpoxy-based silsesquioxane (EOVS) was successfully oxidized from octavinyl silsesquioxane (OVS) and then prepared the E51/BADCy/EOVS nanocomposites with epoxy resin and cyanate ester. With EOVS additions, a lower value of dielectric constant was achieved due to the increased free volume. The positron annihilation lifetime spectroscopy (PALS) demonstrated more nanocavity introduced by POSS increased ...
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The low-k epoxy/cyanate nanocomposite modified with epoxy-based POSS: The effect of microstructure on dielectric propertiesReactive and Functional Polymers Pub Date : 2023-02-03 ,DOI:10.1016/j.reactfunctpolym.2023.105522Xiaodan Li, Xiaoqing Liu, Hongyu Liu, Rui He, Feng Wang, Shiyun Meng, Zhaomin LiEpoxy-based silsesquioxane (EOVS) was successfully oxidized from octavinyl silsesquioxane (OVS) and then prepared the E51/BADCy/EOVS nanocomposites with epoxy resin and cyanate ester. With EOVS additions, a lower value of dielectric constant was achieved due to the increased free volume. The positron annihilation lifetime spectroscopy (PALS) demonstrated more nanocavity introduced by POSS increased ...
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Network Pharmacology-Based Identification of Key Targets of Ziyin Mingmu Pills Acting on Age-Related Macular DegenerationEvidence-based Complementary and Alternative Medicine (IF 2.65) Pub Date : 2023-2-2 ,DOI:10.1155/2023/5933125Yijing Yang, Ying Wang, Xiaoqing Liu, Ying Deng, Jing Lu, Feipeng Jiang, Fujiao Nie, Jun Peng, Qinghua Peng, Yuhui Qin
Objective. This study is designed to find out the molecular targets of effective Chinese medicine Ziyin Mingmu pills (ZMPs) in treating age-related macular degeneration (AMD) based on network pharmacology and experimental data. Methods. A comprehensive network pharmacology strategy that consists of three sequential modules (drug-disease target molecular docking, enrichment analysis, and external verification)
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Impact of cardiovascular health and genetic risk on coronary artery disease in Chinese adultsHeart (IF 7.365) Pub Date : 2023-02-02 ,DOI:10.1136/heartjnl-2022-321657Qingmei Cui, Zhongying Liu, Jianxin Li, Fangchao Liu, Xiaoge Niu, Chong Shen, Dongsheng Hu, Keyong Huang, Shufeng Chen, Yingxin Zhao, Fanghong Lu, Xiaoqing Liu, Jie Cao, Laiyuan Wang, Hongxia Ma, Ling Yu, Xianping Wu, Ying Li, Huan Zhang, Xingbo Mo, Liancheng Zhao, Zhibin Hu, Hongbing Shen, Jianfeng Huang, Xiangfeng Lu, Dongfeng GuObjective To examine whether adherence to ideal cardiovascular health (CVH) can mitigate the genetic risk of coronary artery disease (CAD) in non-European populations. Methods Fine and Grey’s models were used to calculate HRs and their corresponding 95% CIs, as well as the lifetime risk of CVH metrics across Polygenic Risk Score (PRS) categories. Results We included 39 755 individuals aged 30–75 years ...
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Recyclable bio-based epoxy resins containing hybrid cross-linking networksPolymers for Advanced Technologies (IF 3.348) Pub Date : 2023-02-01 ,DOI:10.1002/pat.5994Jingyuan Hu, Haoyang Feng, Yangke Rong, Shuaipeng Wang, Dandan Jin, Qing Chen, Jinyue Dai, Xiaoqing LiuBio-based “thiol-epoxides” thermosets containing dynamic cross-linked network topologies, permanent cross-linking and recyclability have been successfully utilized in coatings, adhesives and composites. However, these materials typically have a low glass transition temperature and limited mechanical strength. Combining excellent mechanical properties with thermal properties remains a significant challenge ...
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