- 作 者: ( "yingliang wu" OR "ying-liang wu" )
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Optimal strategies of social commerce platforms in the context of forwarding and bargainingOperational Research (IF 1.759) Pub Date : 2023-03-08 ,DOI:10.1007/s12351-023-00768-8Xu Chen, Yingliang Wu, Rujie Zhong“Forwarding and bargaining” is a new marketing pattern in social commerce that fully utilizes consumers’ social relationships and offers an alternative for enterprises struggling with traditional e-commerce platforms. In this paper, we assume a Stackelberg game model between a social commerce platform and an e-commerce enterprise to investigate their strategy changes in four scenarios under the forwarding ...
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Key domains and residues of the receptor MRGPRX1 recognizing the peptide ligand BAM8-22Peptides Pub Date : 2022-12-22 ,DOI:10.1016/j.peptides.2022.170927Jing Hu, Luyao Wang, Haifeng Yang, Yuanyuan Meng, Min Tao, Yingliang Wu, Zhijian CaoMas-related G protein-coupled receptors (Mrgprs) are a newly discovered class of G protein-coupled receptors consisting of more than 50 members in recent years. MRGPRX1 can be activated by bovine adrenal medulla peptide 8–22 (BAM8–22), triggering Ca2+ influx and then causing pain and itch. It is very important for the discovery of analgesic and antipruritic drugs to elucidate the molecular mechanism ...
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Design, synthesis and antitumor activity of novel thiophene- triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorssBioorganic & Medicinal Chemistry (IF 3.461) Pub Date : 2022-12-16 ,DOI:10.1016/j.bmc.2022.117133Shan Xu, Leixuan Luo, Xin Sun, Yang Yang, Qiuyan Guo, Zhiyan Jiang, Yingliang WuIn this article, we designed and synthesized a series of novel thiophene-triazine derivatives bearing arylurea unit as potent dual PI3K/mTOR inhibitors. The cytotoxicity of all the target compounds were evaluated against nine cancer cell lines (breast cancer cell line MCF-7, lung cancer cell lines A549, NCI-H460, H2228 and H1975, cervical cancer cell lines Hela and Hela-MDR, ovarian cancer cell lines ...
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Correction: Sj7170, a unique dual-function peptide with a specific α-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venomJournal of Biological Chemistry (IF 5.486) Pub Date : 2022-10-21 ,DOI:10.1016/j.jbc.2022.102543Yu Song, Ke Gong, Hong Yan, Wei Hong, Le Wang, Yingliang Wu, Wenhua Li, Wenxin Li, Zhijian CaoAbstract not available ...
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Proteomic Analysis of Exudates from Chronic Ulcer of Diabetic Foot Treated with Scorpion Antimicrobial PeptideMediators of Inflammation (IF 4.529) Pub Date : 2022-10-3 ,DOI:10.1155/2022/5852786Zhixiang Tan, Zhiguo Yu, Xiaobo Xu, Lanxia Meng, Mosheng Yu, Rui Tao, Yingliang Wu, Zhanyong Zhu
Scorpion peptides have good therapeutic effect on chronic ulcer of diabetic foot, but the related pharmacological mechanism has remained unclear. The different proteins and bacteria present in ulcer exudates from chronic diabetic foot patients, treated with scorpion antimicrobial peptide at different stages, were analyzed using isobaric tags for quantification-labeled proteomics and bacteriological
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XS-2, a novel potent dual PI3K/mTOR inhibitor, exhibits high in vitro and in vivo anti-breast cancer activity and low toxicity with the potential to inhibit the invasion and migration of triple-negative breast cancerBiomedicine & Pharmacotherapy (IF 7.419) Pub Date : 2022-09-13 ,DOI:10.1016/j.biopha.2022.113537Sun, Leixuan Luo, Yang Yang, Qiuyan Guo, Sheng Tang, Zhiyan Jiang, Yuzhen Li, Jiaqian Han, Wenhui Gan, Feiyi Yang, Xuan Zhang, Yijun Liu, Chuanchuan Sun, Jie He, Meng Liu, Daiying Zuo, Wufu Zhu, Yingliang Wu
Breast cancer has become the most commonly diagnosed cancer, surpassing lung cancer, with 2.26 million new breast cancers worldwide in 2020. Hence, there is an urgent need to develop effective molecularly targeted therapeutic drugs to treat breast cancer. In this paper, we designed, synthesized and screened a novel thiophene-triazine derivative, XS-2, as a potent dual PI3K/mTOR inhibitor for the treatment
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Mechanisms Underlying the Inhibition of KV1.3 Channel by Scorpion Toxin ImKTX58Molecular Pharmacology (IF 4.054) Pub Date : 2022-09-01 ,DOI:10.1124/molpharm.121.000480Xu Zhang, Qianru Zhao, Fan Yang, Zhen Lan, Yi Li, Min Xiao, Hui Yu, Ziyi Li, Yongsheng Zhou, Yingliang Wu, Zhijian Cao, Shijin Yin
Voltage-gated KV1.3 channel has been reported to be a drug target for the treatment of autoimmune diseases, and specific inhibitors of Kv1.3 are potential therapeutic drugs for multiple diseases. The scorpions could produce various bioactive peptides that could inhibit KV1.3 channel. Here, we identified a new scorpion toxin polypeptide gene ImKTX58 from the venom gland cDNA library of the Chinese scorpion
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Distinguishing the most valuable consumers in social commerce using graphical evaluation and review technique – in the view of incentivesKybernetes (IF 2.352) Pub Date : 2022-08-19 ,DOI:10.1108/k-03-2022-0384Xu Chen, Yingliang Wu, Junfeng Liao, Wenming Zuo, Rujie ZhongPurpose The incentive cost of enterprises increases significantly with the rapid growth of the social commerce (SC) market. In this context, enterprises need to develop the optimal strategy to improve incentive effectiveness and reduce cost. Different types of consumers’ responses to incentives bring different values to enterprises. Hence, this paper proposes the social commerce value network (SCVN) ...
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Dynamic synthesis and transport of fluorescent substances from moulting scorpionsJournal of Photochemistry and Photobiology B: Biology (IF 6.814) Pub Date : 2022-07-06 ,DOI:10.1016/j.jphotobiol.2022.112511Songryong Li, Cholman Kim, Shaozhi Zong, Yuqing Liu, Jongguk Kang, Cholmin Pak, Zhijian Cao, Yingliang WuScorpion fluorescence under ultraviolet light is a well-known phenomenon, and its change is also a known biological feature during the scorpion moulting process. However, the synthesis and transport of fluorescent substances during the moulting stage remain unclear. In this study, in-depth investigations on the global fluorescence changes from the exoskeleton, fluorescence layer, coelomic fluid, and ...
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1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cellsToxicology and Applied Pharmacology (IF 4.46) Pub Date : 2022-07-06 ,DOI:10.1016/j.taap.2022.116156Xing Chang, Junfang Wang, Jiang Bian, Zi Liu, Ming Guo, Zengqiang Li, Yingliang Wu, Xin Zhai, Daiying ZuoAnaplastic lymphoma kinase (ALK) belongs to the family of receptor tyrosine kinases. Recently, the incidence of anaplastic large cell lymphoma (ALCL) with ALK rearrangement has raised considerably. The application of ALK-targeted inhibitors such as ceritinib provides an effective therapy for the treatment of ALK-positive cancers. However, with the prolongation of treatment time, the emergence of resistance ...
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Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transportersNature Communications (IF 17.694) Pub Date : 2022-06-21 ,DOI:10.1038/s41467-022-31149-yWang, Xiafei Yu, Yonghui Zhao, Zili Xie, Kailian Zhang, Zhexu Chi, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Yuxian Guo, Xuyan Yang, Xue Zhang, Yingliang Wu, Wei Yang, Di Wang
Immunometabolism contributes to inflammation, but how activated macrophages acquire extracellular nutrients to fuel inflammation is largely unknown. Here, we show that the plasma membrane potential (Vm) of macrophages mediated by Kir2.1, an inwardly-rectifying K+ channel, is an important determinant of nutrient acquisition and subsequent metabolic reprogramming promoting inflammation. In the absence
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A novel tubulin inhibitor, 6h, suppresses tumor-associated angiogenesis and shows potent antitumor activity against non–small cell lung cancersJournal of Biological Chemistry (IF 5.486) Pub Date : 2022-05-23 ,DOI:10.1016/j.jbc.2022.102063Zi Liu, Liancheng Huang, Tianhao Zhou, Xing Chang, Yuying Yang, Yani Shi, Mingjing Hao, Zengqiang Li, Yingliang Wu, Qi Guan, Weige Zhang, Daiying Zuo
Tumor angiogenesis is closely associated with the metastasis and progression of non–small cell lung cancer (NSCLC), a highly vascularized solid tumor. However, novel therapeutics are lacking for the treatment of this cancer. Here, we developed a series of 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazol analogs (6a–6x) as tubulin colchicine-binding site inhibitors, aiming to find a novel
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The Pathophysiology of Long COVID throughout the Renin-Angiotensin SystemMolecules (IF 4.927) Pub Date : 2022-05-02 ,DOI:10.3390/molecules27092903Shaymaa Khazaal, Julien Harb, Mohamad Rima, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Ziad Abi Khattar, Christian Legros, Hervé Kovacic, Ziad Fajloun, Jean-Marc Sabatier
COVID-19 has expanded across the world since its discovery in Wuhan (China) and has had a significant impact on people’s lives and health. Long COVID is a term coined by the World Health Organization (WHO) to describe a variety of persistent symptoms after acute SARS-CoV-2 infection. Long COVID has been demonstrated to affect various SARS-CoV-2-infected persons, independently of the acute disease severity
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Identification of an arthropod molecular target for plant-derived natural repellentsProceedings of the National Academy of Sciences of the United States of America (IF 12.779) Pub Date : 2022-04-22 ,DOI:10.1073/pnas.2118152119Quan Tian, Peiyu Wang, Chang Xie, Peiyuan Pang, Youjing Zhang, Yue Gao, Zhijian Cao, Yingliang Wu, Wenxin Li, Michael X. Zhu, Dongdong Li, Jing Yao
Significance Rational control of arthropod pests is important for animal and human health as well as biodiversity preservation. As an alternative to synthetic chemical pesticides, natural repellents represent an ecological method of pest control. Through an exceptional gene library screening in Mesobuthus martensii scorpions, we here uncover a transient receptor potential ion channel as the chemosensory
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Correction to: Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 PathwaysNeurotoxicity Research (IF 3.978) Pub Date : 2022-04-13 ,DOI:10.1007/s12640-022-00491-wDaiying Zuo, Li Lin, Yumiao Liu, Chengna Wang, Jingwen Xu, Feng Sun, Lin Li, Zengqiang Li, Yingliang Wu
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2-Methoxy-5((3,4,5-trimethosyphenyl) seleninyl) phenol causes G2/M cell cycle arrest and apoptosis in NSCLC cells through mitochondrial apoptotic pathway and MDM2 inhibitionJournal of Biochemical and Molecular Toxicology (IF 3.568) Pub Date : 2022-04-05 ,DOI:10.1002/jbt.23066Yang Liu, Yuting Meng, Jiang Bian, Bolin Liu, Xuefen Li, Qi Guan, Zengqiang Li, Weige Zhang, Yingliang Wu, Daiying ZuoNonsmall cell lung cancer (NSCLC) is one of the most common malignancies and needs novel and effective chemotherapy. In this study, our purpose is to explore the anticancer effects of 2-methoxy-5((3,4,5-trimethosyphenyl) seleninyl) phenol (SQ) on human NSCLC (A549 and H460) cells. We found that SQ suppressed the proliferation of NSCLC cells in time- and dose-dependent manners, and blocked the cells ...
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Corrigendum to "Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA" [Neurotoxicology 44 (2014) 218-230].Neurotoxicology Pub Date : 2022-03-29 ,DOI:10.1016/j.neuro.2022.03.006Daiying Zuo,Chengna Wang,Zengqiang Li,Li Lin,Zhenfang Duan,Huan Qi,Lin Li,Feng Sun,Yingliang Wu
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Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated DiseasesMolecules (IF 4.927) Pub Date : 2022-03-22 ,DOI:10.3390/molecules27072048George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin–angiotensin system (RAS) in favor of the ACE–angiotensin II (Ang II)–angiotensin II type I receptor (AT1R) axis. AT1R has a major role in RAS by being
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Corrigendum to "5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine (WY-135), a novel ALK inhibitor, induces cell cycle arrest and apoptosis through inhibiting ALK and its downstream pathways in Karpas299 and H2228 cells" [Chem. Biol. Interact. 284 (2018) 24-31].Chemico-Biological Interactions (IF 5.168) Pub Date : 2022-02-28 ,DOI:10.1016/j.cbi.2022.109871Mengting Han,Jiwei Shen,Lijing Wang,Yu Wang,Xin Zhai,Yao Li,Meiqiao Liu,Meiqi Gao,Zengqiang Li,Daiying Zuo,Yingliang Wu
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The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucoseChemico-Biological Interactions (IF 5.168) Pub Date : 2022-02-02 ,DOI:10.1016/j.cbi.2022.109843Minghuan Gao, Yuying Yang, Ying Gao, Tong Liu, Qi Guan, Tianhao Zhou, Yani Shi, Mingjing Hao, Zengqiang Li, Daiying Zuo, Weige Zhang, Yingliang WuAerobic glycolysis is a hallmark of malignant tumor. Here, the hyperactive glycolysis in multidrug-resistant A549/Taxol cells was demonstrated to be essential for maintaining the vigorous cell viability and drug resistance. 5-(4-ethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-3-amine (YAN), a newly synthesized tubulin inhibitor, could not only inhibit the glycolysis in A549 and A549/Taxol ...
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EML4-ALK G1202R mutation induces EMT and confers resistance to ceritinib in NSCLC cells via activation of STAT3/Slug signalingCellular Signalling (IF 4.85) Pub Date : 2022-01-24 ,DOI:10.1016/j.cellsig.2022.110264Jiwei Shen, Yuting Meng, Kunlun Wang, Minghuan Gao, Jianan Du, Junfang Wang, Zengqiang Li, Daiying Zuo, Yingliang WuThe echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) fusion gene occurs in approximately 5% of non-small-cell lung cancers (NSCLCs). The development of ALK tyrosine kinase inhibitors (ALK-TKIs) is a major advance in treating NSCLC with the ALK fusion gene. Nevertheless, acquired resistance to ALK-TKIs ultimately limits their use. A prevalent mechanism of drug ...
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p38 activation and viral infectionExpert Reviews in Molecular Medicine (IF 7.615) Pub Date : 2022-01-21 ,DOI:10.1017/erm.2021.29Luyao Wang, Zhiqiang Xia, Wei Tang, Yu Sun, Yingliang Wu, Hang Fai Kwok, Fang Sun, Zhijian CaoViruses completely rely on the energy and metabolic systems of host cells for life activities. Viral infections usually lead to cytopathic effects and host diseases. To date, there are still no specific clinical vaccines or drugs against most viral infections. Therefore, understanding the molecular and cellular mechanisms of viral infections is of great significance to prevent and treat viral diseases ...
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Targeted inhibition of acidic nucleoplasmic DNA-binding protein 1 enhances radiosensitivity of non-small cell lung cancerCancer Letters (IF 9.756) Pub Date : 2022-01-20 ,DOI:10.1016/j.canlet.2022.01.020Wenfeng Gou, Xiaojun Yu, Shaohua Wu, Hongying Wu, Huajie Chang, Leyuan Chen, Huiqiang Wei, Changfen Bi, Hongxin Ning, Yingliang Wu, Wenbin Hou, Daiying Zuo, Yiliang LiAcidic nucleoplasmic DNA binding protein 1 (AND-1, also known as WD repeat and HMG-box DNA-binding protein 1, WDHD1) plays an important role in DNA replication and repair, but the relationship between AND-1 and radiosensitivity is not well understood. This research explored the impact of AND-1 on the radiosensitivity of non-small cell lung cancer (NSCLC) for the first time. NSCLC cells were treated ...
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Novel microtubule inhibitor SQ overcomes multidrug resistance in MCF-7/ADR cells by inhibiting BCRP function and mediating apoptosisToxicology and Applied Pharmacology (IF 4.46) Pub Date : 2022-01-12 ,DOI:10.1016/j.taap.2022.115883Xing Chang, Zi Liu, Simeng Cao, Jiang Bian, Dayong Zheng, Nuo Wang, Qi Guan, Yingliang Wu, Weige Zhang, Zengqiang Li, Daiying ZuoThe occurrence of multidrug resistance (MDR) is one of the impediments in the clinical treatment of breast cancer, and MDR breast cancer has abnormally high breast cancer resistance protein (BCRP/ABCG2) expression. However, there are currently no clinical drugs that inhibit this target. Our previous study found that 2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ0814061/SQ), a small molecule ...
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SARS-CoV-2-Induced Neurological Disorders in Symptomatic Covid-19 and Long Covid Patients: Key Role of Brain Renin-Angiotensin System.Infectious disorders drug targets Pub Date : 2022-01-01 ,DOI:10.2174/1871526522666220406124618Ziad Fajloun,Hervé Kovacic,Cédric Annweiler,Yingliang Wu,Zhijian Cao,Jean-Marc Sabatier
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The Renin-Angiotensin System: A Key Role in SARS-CoV-2- Induced COVID-19Molecules (IF 4.927) Pub Date : 2021-11-17 ,DOI:10.3390/molecules26226945George El-Arif, Antonella Farhat, Shaymaa Khazaal, Cédric Annweiler, Hervé Kovacic, Yingliang Wu, Zhijian Cao, Ziad Fajloun, Ziad Abi Khattar, Jean Marc Sabatier
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), was first identified in Eastern Asia (Wuhan, China) in December 2019. The virus then spread to Europe and across all continents where it has led to higher mortality and morbidity, and was declared as a pandemic by the World Health Organization (WHO) in March 2020. Recently
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ML-SA1 and SN-2 inhibit endocytosed viruses through regulating TRPML channel expression and activityAntiviral Research (IF 10.103) Pub Date : 2021-10-20 ,DOI:10.1016/j.antiviral.2021.105193Zhiqiang Xia, Yingying Ren, Songryong Li, Jiyuan Xu, Yingliang Wu, Zhijian CaoTransient receptor potential mucolipin 2 and 3 (TRPML2 and TRPML3), as key channels in the endosomal-lysosomal system, are associated with many different cellular processes, including ion release, membrane trafficking and autophagy. In particular, they can also facilitate viral entry into host cells and enhance viral infection. We previously identified that two selective TRPML agonists, ML-SA1 and ...
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BmK86-P1, a New Degradation Peptide with Desirable Thermostability and Kv1.2 Channel-Specific Activity from Traditional Chinese Scorpion Medicinal MaterialToxins (IF 5.075) Pub Date : 2021-08-30 ,DOI:10.3390/toxins13090610Chenhu Qin, Xuhua Yang, Zheng Zuo, Liuting Yang, Fan Yang, Zhijian Cao, Zongyun Chen, Yingliang Wu
Thermally processed Buthus martensii Karsch scorpions are a traditional Chinese medical material for treating various diseases. However, their pharmacological foundation remains unclear. Here, a new degraded peptide of scorpion toxin was identified in Chinese scorpion medicinal material by proteomics. It was named BmK86-P1 and has six conserved cysteine residues. Homology modeling and circular dichroism
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AKT controls NLRP3 inflammasome activation by inducing DDX3X phosphorylationFEBS Letters (IF 3.864) Pub Date : 2021-08-13 ,DOI:10.1002/1873-3468.14175Xingchen Guo, Sheng Chen, Weiwei Yu, Zhexu Chi, Zhen Wang, Ting Xu, Jian Zhang, Danlu Jiang, Yuxian Guo, Hui Fang, Kailian Zhang, Mobai Li, Dehang Yang, Qianzhou Yu, Qizhen Ye, Di Wang, Xue Zhang, Yingliang WuThe NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin-1β maturation and drives cell fate toward pyroptosis. However, the mechanism of NLRP3 inflammasome activation still remains elusive. Here we provide evidence that AKT regulates NLRP3 inflammasome activation. Upon NLRP3 activation, AKT activity is inhibited by second stimulus-induced ...
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The rapid development of the first instar telson with venom secretion highlights the remarkable survival ability of scorpionsToxicon (IF 3.035) Pub Date : 2021-08-12 ,DOI:10.1016/j.toxicon.2021.08.004Songryong Li, Unchol Ri, Chenhu Qin, Yiyuan Guo, Changho Ri, Wenxin Li, Zhijian Cao, Yingliang WuThe scorpion venom system plays a critical role in capturing prey and defending against predators. In this study, the rapid developmental process of the first instar telson was first presented. The small amount of venom in the first instar could be stored well by the distorted and blocked venom ducts, which disappeared in the older scorpions. This special developmental process of the first instar telson ...
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