- 作 者: ( "wenhao hu" OR "wen-hao hu" )
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Herbaceous ornamental plants with conspicuous aesthetic traits contribute to plant invasion risk in subtropical urban parksJournal of Environmental Management (IF 8.7) Pub Date : 2023-09-26 , DOI:10.1016/j.jenvman.2023.119059Siwei Hu, Cheng Jin, Ruiyan Liao, Li Huang, Lihua Zhou, Yuxiao Long, Min Luo, C.Y. Jim, Wenhao Hu, Dunmei Lin, Shengbin Chen, Changjing Liu, Yanxue Jiang, Yongchuan YangGlobal ornamental horticulture is a major pathway for plant invasions, while urban parks are key areas for introducing non-native ornamental plants. To react appropriately to the challenges (e.g., biological invasion issues) and opportunities (e.g., urban ecosystem services) of herbaceous ornamentals in urban parks, we conducted a comprehensive invasive risk assessment in 363 urban parks in Chongqing ...
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Magnetic Resonance Imaging-Based Classification Systems for Informing Better Outcomes of Adenomyosis After Ultrasound-Guided High-Intensity Focused Ultrasound Ablating SurgeryJournal of Magnetic Resonance Imaging (IF 4.4) Pub Date : 2023-09-06 , DOI:10.1002/jmri.28943Ying Tang, Wen-hao Hu, Hang Wang, Jia Wu, Ming-bo Wen, Bin Su, Zhi-jun Jiang, Xiao Jiang, Li-juan Zhu, Na Ding, Ming-tao Yang, Shu Yin, Hui-quan Hu, Fan Xu, Jun Li, Qiuling ShiA referenced MRI-based classification associated with focused ultrasound ablation surgery (FUAS) outcomes is lacking in adenomyosis. ...
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Giant panda loan exhibitions in China underdeliver on educating visitors: insights and recommendations for improvementsOryx (IF 2.7) Pub Date : 2023-09-04 , DOI:10.1017/s0030605322001545Xuemei Yao, Wei Li, Wenhao Hu, Ling Zhang, Dingzhen Liu
Giant panda Ailuropoda melanoleuca exhibits are popular attractions for zoos and wildlife parks. However, it remains to be investigated whether such exhibits enhance visitor knowledge about pandas and broader conservation issues. We conducted questionnaire surveys at giant panda exhibits at three city zoos and five wildlife parks in China. Although visitors were generally interested in the giant panda
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Catalytic Asymmetric P–H Insertion ReactionsJournal of the American Chemical Society (IF 15.0) Pub Date : 2023-08-29 , DOI:10.1021/jacs.3c06906Xiu Gu, Xiaoyu Mo, Wen-Ju Bai, Peng Xie, Wenhao Hu, Jun JiangAlbeit notable endeavors in enantioselective carbene insertion into X–H bonds (X = C, O, N, S, Si, B), the catalytic asymmetric P–H insertion reactions still stand for a long-lasting challenge. By merging transition-metal catalysis with organocatalysis, we achieve a scalable enantioselective P–H insertion transformation between diazo pyrazoleamides and H-phosphine oxides that upon subsequent reduction ...
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Rapid visual detection of Vibrio parahaemolyticus by combining LAMP-CRISPR/Cas12b with heat-labile uracil-DNA glycosylase to eliminate carry-over contaminationJournal of Zhejiang University-SCIENCE B (IF 2.082) Pub Date : 2023-08-15 , DOI:10.1631/jzus.b2200705Fang Wu, Chen Lu, Wenhao Hu, Xin Guo, Jiayue Chen, Zhidan Luo作为海产品中的主要致病菌, 副溶血弧菌的快速准确检测对于海水健康养殖和避免副溶血弧菌相关食源性疾病的发生至关重要. 本研究结合尿嘧啶DNA糖苷酶(UDG)、 环介导等温扩增(LAMP)和CRISPR/Cas12b技术, 建立了海产品中副溶血弧菌的一锅法检测技术. 该检测系统实现了一管化检测, 并可避免残留污染的风险. 我们通过优化dNTP混合物中dTTP/dUTP比例, 并筛选出最优sgRNA. 该方法在最优条件下, 对副溶血弧菌纯培养物的检出限低至1×102 CFU/mL, 在虾肉样品的检出限低至1×102 CFU/g. 该方法对其他微生物病原体无交叉反应, 且与荧光定量PCR结果符合率为100%. ...
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Silver-catalyzed pyrazole migration and cycloaddition reaction of diazo pyrazoleamides with ketiminesChemical Communications (IF 4.9) Pub Date : 2023-07-31 , DOI:10.1039/d3cc03253aMaoqing Shi, Gejun Niu, Tianyuan Zhang, Aimin Xu, Rimei Zheng, Abdulla Yusuf, Taoda Shi, Wenhao Hu, Yu QianA novel pyrazole migration and cycloaddition process is well developed via AgOTf-catalyzed annulation reactions of α-diazo pyrazoleamides with ketimines. This protocol discloses efficient access to synthesize a series of spirooxindole-based β-lactams in good to excellent yields and the diastereoselectivity is switchable by tuning the substituents on the α-diazo pyrazoleamides. ...
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Asymmetric Acyclic 1,3-Difunctionalization of Vinyl Carbenes via Site-Selective Vinylogous Mannich-Type Interception of Oxonium YlidesOrganic Letters (IF 5.2) Pub Date : 2023-07-13 , DOI:10.1021/acs.orglett.3c01983Rimei Zheng, Aimin Xu, Tianyuan Zhang, Pei Li, Maoqing Shi, Shanliang Dong, Wenhao Hu, Yu QianA novel and highly stereoselective acyclic 1,3-difunctionalization of vinyl metal carbene species has been developed via Rh(II)/chiral phosphoric acid co-catalyzed three-component reactions of vinyldiazoacetates with alcohols and imines. This innovative approach features excellent regio-, diastereo-, and enantioselectivities, demonstrating a broad scope and functional group compatibility. Notably, ...
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A Survey of Deep Learning in Sports Applications: Perception, Comprehension, and DecisionarXiv - CS - Computer Vision and Pattern Recognition Pub Date : 2023-07-07 , DOI:arxiv-2307.03353Zhonghan Zhao, Wenhao Chai, Shengyu Hao, Wenhao Hu, Guanhong Wang, Shidong Cao, Mingli Song, Jenq-Neng Hwang, Gaoang WangDeep learning has the potential to revolutionize sports performance, with applications ranging from perception and comprehension to decision. This paper presents a comprehensive survey of deep learning in sports performance, focusing on three main aspects: algorithms, datasets and virtual environments, and challenges. Firstly, we discuss the hierarchical structure of deep learning algorithms in sports ...
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Benefits of Jasminum polyanthum's natural aromas on human emotions and moodsUrban Forestry & Urban Greening (IF 6.4) Pub Date : 2023-06-23 , DOI:10.1016/j.ufug.2023.128010Xi Xiong, Hexian Jin, Wenhao Hu, Chengcheng Zeng, Qian Huang, Xue Cui, Mingke Zhang, Yalu JinAromatic plants hold great potential to affect the health of urban residents. Studying the positive effects of natural aromas emitted by aromatic plants on urban residents is necessary. In this research, Pink Jasmine (Jasminum polyanthum), a woody vine species widely used in urban landscape, was selected as the research subject to address the following research questions: Whether the natural aromas ...
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MTX-13, a novel PTK7-directed antibody-drug conjugate with widened therapeutic index shows sustained tumor regressions for a broader spectrum of PTK7-positive tumors.Molecular Cancer Therapeutics (IF 5.7) Pub Date : 2023-06-23 , DOI:10.1158/1535-7163.mct-23-0164Chao Kong,Junyi Pu,Qianqian Zhao,Weining Weng,Linjie Ma,Yu Qian,Wenhao Hu,Xun Meng,Tao Meng
Protein tyrosine kinase 7 (PTK7) is a Wnt signaling pathway protein implicated in cancer development and metastasis. When using a potent microtubule inhibitor (Aur0101), PTK7-targeting antibody-drug conjugate (ADC), h6M24-vc0101 (PF-06647020/Cofetuzumab pelidotin) is efficacious only in limited tumor types with low response rates in a phase I trial. To improve patient response and to expand responding
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AMT-562, a novel HER3-targeting antibody drug conjugate, demonstrates a potential to broaden therapeutic opportunities for HER3-expressing tumors.Molecular Cancer Therapeutics (IF 5.7) Pub Date : 2023-06-11 , DOI:10.1158/1535-7163.mct-23-0198Weining Weng,Tao Meng,Junyi Pu,Linjie Ma,Yi Shen,Zhaohui Wang,Rong Pan,Mingqiao Wang,Caiwei Chen,Lijun Wang,Jianjian Zhang,Biao Zhou,Siyuan Shao,Yu Qian,Shu-Hui Liu,Wenhao Hu,Xun Meng
HER3 is a unique member of the epidermal growth factor receptor family of tyrosine kinases, which is broadly expressed in several cancers, including breast, lung, pancreatic, colorectal, gastric, prostate, and bladder cancers and is often associated with poor patient outcomes and therapeutic resistance. U3-1402/Patritumab-GGFG-DXd is the first successful HER3-targeting ADC molecule with clinical efficacy
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Improvement of duplex-specific nuclease salt tolerance by fusing DNA-binding domain of DNase from an extremely halotolerant bacterium Thioalkalivibrio sp. K90mixExtremophiles (IF 2.9) Pub Date : 2023-05-13 , DOI:10.1007/s00792-023-01296-1Wenhao Hu, Jin Wang, Juan Li, Mengxia Yang, Zhixing Li, Xuning Zhang, Fang Wu, Yaqi Zhang, Zhidan Luo, Henghao XuSalt tolerance is an important property of duplex-specific nuclease (DSN). DSN with high salt tolerance can be more widely used in genetic engineering, especially in the production of nucleic acid drugs. To improve the salt tolerance of DSN, we selected five DNA-binding domains from extremophilic organisms, which have been shown the ability to improve salt tolerance of DNA polymerases and nucleases ...
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Molecular testing-guided therapy versus susceptibility testing-guided therapy in first-line and third-line Helicobacter pylori eradication: two multicentre, open-label, randomised controlled, non-inferiority trialsThe Lancet Gastroenterology & Hepatology (IF 35.7) Pub Date : 2023-05-10 , DOI:10.1016/s2468-1253(23)00097-3Mei-Jyh Chen, Po-Yueh Chen, Yu-Jen Fang, Ming-Jong Bair, Chieh-Chang Chen, Chien-Chuan Chen, Tsung-Hua Yang, Ji-Yuh Lee, Chien-Chun Yu, Chia-Chi Kuo, Min-Chin Chiu, Chu-Kuang Chou, Chi-Yi Chen, Wen-Hao Hu, Min-Horn Tsai, Yao-Chun Hsu, Chia-Tung Shun, Jiing-Chyuan Luo, Jaw-Town Lin, Emad M El-Omar, Jyh-Ming LiouBackground Helicobacter pylori infection is an important causal factor of gastric cancer and peptic ulcer disease and is associated with immune thrombocytopenic purpura and functional dyspepsia. In H pylori strains, point mutations in the 23S rRNA and gyrA genes are associated with clarithromycin resistance and levofloxacin resistance, respectively. Whether the efficacy of molecular testing-guided ...
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Discovery and Optimization of Novel Biphenyl Derivatives Bearing Cyclopropyl Linkage as Potent Programmed Cell Death-1/Programmed Cell Death-Ligand 1 InhibitorsJournal of Medicinal Chemistry (IF 7.3) Pub Date : 2023-05-09 , DOI:10.1021/acs.jmedchem.3c00205Tongfei Jing, Zhijing Zhang, Zhenghui Kang, Jianshan Mo, Xiaotong Yue, Ziyou Lin, Xiang Fu, Chang Liu, Hang Ma, Xiaolei Zhang, Wenhao HuA series of novel compounds bearing a cyclopropyl linkage were designed, synthesized, and evaluated as programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) inhibitors. An optimized compound (1S,2S)-A25 showed potent inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 0.029 μM) with a selected binding affinity with PD-L1 (KD = 1.554 × 10–1 μM). Additionally, under the co-culture ...
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Improving 2D face recognition via fine-level facial depth generation and RGB-D complementary feature learningarXiv - CS - Computer Vision and Pattern Recognition Pub Date : 2023-05-08 , DOI:arxiv-2305.04426Wenhao HuFace recognition in complex scenes suffers severe challenges coming from perturbations such as pose deformation, ill illumination, partial occlusion. Some methods utilize depth estimation to obtain depth corresponding to RGB to improve the accuracy of face recognition. However, the depth generated by them suffer from image blur, which introduces noise in subsequent RGB-D face recognition tasks. In ...
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A sustainable synthesis of 3,3-disubstituted oxindoles via CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrileGreen Synthesis and Catalysis Pub Date : 2023-05-07 , DOI:10.1016/j.gresc.2023.04.006Mengchu Zhang, Yukai Li, Yuwei Wang, Jirong Shu, Tianyuan Zhang, Dan Zhang, Song Cai, Taoda Shi, Wenhao Hu
We herein reported a sustainable synthesis of 3,3-disubstituted oxindoles via a Michael-type reaction based on the CuBr-catalysed capture of carboxylic oxonium ylides with isatylidene malononitrile. The reaction is characterized by a high atom economy and low economic constraints. The catalyst CuBr could be conveniently recyclized. The products of the reaction were found to be inhibitory against Na
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Construction of Chiral Quaternary Carbon Centers via Asymmetric Metal Carbene gem-DialkylationAngewandte Chemie International Edition (IF 16.6) Pub Date : 2023-05-02 , DOI:10.1002/anie.202302371Shanliang Dong, Kemiao Hong, Zhijing Zhang, Jingjing Huang, Xiongda Xie, Haoxuan Yuan, Wenhao Hu, Xinfang XuAn enantioselective three-component reaction of α-diazo ketones with alkenes and 1,3,5-triazines is reported, which leads to poly-functionalized chiral ketones with excellent enantioselectivity. This unprecedented metal carbene gem-dialkylation reaction features a cascade formal asymmetric allylation and aminomethylation process with concomitant construction of all-carbon quaternary stereocenters using ...
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Regio- and diastereoselective construction of conjugate oxindole derivatives enabled by delayed acyl transfer of pyridinium ylidesOrganic Chemistry Frontiers (IF 5.4) Pub Date : 2023-04-24 , DOI:10.1039/d3qo00412kMengchu Zhang, Gengxin Liu, Tianyuan Zhang, Kemiao Hong, Xiangji Yang, Huang Qiu, Wenhao HuRegio- and diastereoselective construction of conjugate oxindole moieties has been a daunting challenge in the synthetic community. Herein, we design and develop a one-pot cascade strategy for the assembly of multi-substituted conjugate oxindole derivatives. This methodology involves a rhodium-catalyzed aldol-type interception of pyridinium ylides followed by intramolecular delayed acyl transfer and ...
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Carbon-Centered Radical with Leaving Group-Mediated Ring Opening of Cyclopropenes via the Rearrangement of Cyclopropyl to the Allyl Radical: A General Access to Multisubstituted 1,3-DienesACS Catalysis (IF 12.9) Pub Date : 2023-04-04 , DOI:10.1021/acscatal.3c00619Geng-Xin Liu, Xiao-Ting Jie, Xing-lin Li, Li-Sheng Yang, Huang Qiu, Wen-Hao HuWe design and develop a general strategy for the assembly of multisubstituted 1,3-diene derivatives. This methodology proceeds through the cleavage of cyclopropenes via the rearrangement of the cyclopropyl radical to the allyl radical after the addition of a carbon-centered radical with a leaving group onto the strained double bond, leading to 1,3-diene products with the release of the leaving group ...
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Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer.Cancer Discovery (IF 28.2) Pub Date : 2023-04-03 , DOI:10.1158/2159-8290.cd-22-1368Yi Shen,Guoxiang Fu,Jing Shi,Yue Zhang,Zhaohui Wang,Mingqiao Wang,Rong Pan,Linjie Ma,Caiwei Chen,Lijun Wang,Biao Zhou,Hui Zhang,Junyi Pu,Jianjian Zhang,Yi Peter Hu,Guoqiang Hua,Yu Qian,Shu-Hui Liu,Wenhao Hu,Xun MengAntibody-drug conjugates (ADC) using DNA topoisomerase I inhibitor DXd/SN-38 have transformed cancer treatment, yet more effective ADCs are needed for overcoming resistance. We have designed an ADC class using a novel self-immolative T moiety for traceless conjugation and release of exatecan, a more potent topoisomerase I inhibitor with less sensitivity to multidrug resistance (MDR). Characterized ...
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Blind Inpainting with Object-aware Discrimination for Artificial Marker RemovalarXiv - EE - Image and Video Processing Pub Date : 2023-03-27 , DOI:arxiv-2303.15124Xuechen Guo, Wenhao Hu, Chiming Ni, Wenhao Chai, Shiyan Li, Gaoang WangMedical images often contain artificial markers added by doctors, which can negatively affect the accuracy of AI-based diagnosis. To address this issue and recover the missing visual contents, inpainting techniques are highly needed. However, existing inpainting methods require manual mask input, limiting their application scenarios. In this paper, we introduce a novel blind inpainting method that ...
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Blind Inpainting with Object-aware Discrimination for Artificial Marker RemovalarXiv - CS - Machine Learning Pub Date : 2023-03-27 , DOI:arxiv-2303.15124Xuechen Guo, Wenhao Hu, Chiming Ni, Wenhao Chai, Shiyan Li, Gaoang WangMedical images often contain artificial markers added by doctors, which can negatively affect the accuracy of AI-based diagnosis. To address this issue and recover the missing visual contents, inpainting techniques are highly needed. However, existing inpainting methods require manual mask input, limiting their application scenarios. In this paper, we introduce a novel blind inpainting method that ...
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Blind Inpainting with Object-aware Discrimination for Artificial Marker RemovalarXiv - CS - Computer Vision and Pattern Recognition Pub Date : 2023-03-27 , DOI:arxiv-2303.15124Xuechen Guo, Wenhao Hu, Chiming Ni, Wenhao Chai, Shiyan Li, Gaoang WangMedical images often contain artificial markers added by doctors, which can negatively affect the accuracy of AI-based diagnosis. To address this issue and recover the missing visual contents, inpainting techniques are highly needed. However, existing inpainting methods require manual mask input, limiting their application scenarios. In this paper, we introduce a novel blind inpainting method that ...
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Exome sequencing analysis of gastric primary myeloid sarcoma with monocytic differentiation with altered immunophenotype after chemotherapy: case reportDiagnostic Pathology (IF 2.6) Pub Date : 2023-03-04 , DOI:10.1186/s13000-023-01311-1Xiang Li, Hongxia Zhang, Yong Cui, Haijun Zhang, Yonggang Wang, Meili Ding, Xingyao Zhu, Ruiqi Zhang, Qi Hu, Lin Tao, Wenhao Hu, Xinxia Li, A. O. Qilin, Hong Zou
Myeloid Sarcoma with monocytic differentiation is rare and quite likely is missed by surgical pathologists. However it is frequently misdiagnosed because of its non-specific imaging and histological pattern. We report the case of a 64-year-old woman with gastric primary myeloid sarcoma with monocytic differentiatio. Upper endoscopy revealed a neoplastic growth at the junction of the lesser curvature
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Automatic design of microwave filters by using relational induction neural networksInternational Journal of Numerical Modelling: Electronic Networks, Devices and Fields (IF 1.6) Pub Date : 2023-03-01 , DOI:10.1002/jnm.3102Xi Wang Dai, Wen Hao Hu, Yang Hui Fu, Jie Liu, Zhi Xi ChenAutomatic design of microwave filter based on artificial intelligence is recognized as an alternative to conventional approach, due to the complexity of the structure parameters and the need of enormous solution space. In this paper, an unsupervised, end-to-end training framework, which is named Relational Induction Neural Network (RINN) is proposed. RINN discretizes the model, and makes cluster analysis ...
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Deep Learning Methods for Small Molecule Drug Discovery: A SurveyarXiv - QuanBio - Biomolecules Pub Date : 2023-03-01 , DOI:arxiv-2303.00313Wenhao Hu, Yingying Liu, Xuanyu Chen, Wenhao Chai, Hangyue Chen, Hongwei Wang, Gaoang WangWith the development of computer-assisted techniques, research communities including biochemistry and deep learning have been devoted into the drug discovery field for over a decade. Various applications of deep learning have drawn great attention in drug discovery, such as molecule generation, molecular property prediction, retrosynthesis prediction, and reaction prediction. While most existing surveys ...
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Deep Learning Methods for Small Molecule Drug Discovery: A SurveyarXiv - CS - Machine Learning Pub Date : 2023-03-01 , DOI:arxiv-2303.00313Wenhao Hu, Yingying Liu, Xuanyu Chen, Wenhao Chai, Hangyue Chen, Hongwei Wang, Gaoang WangWith the development of computer-assisted techniques, research communities including biochemistry and deep learning have been devoted into the drug discovery field for over a decade. Various applications of deep learning have drawn great attention in drug discovery, such as molecule generation, molecular property prediction, retrosynthesis prediction, and reaction prediction. While most existing surveys ...
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Synthesis and Characterization of Donor–Acceptor Iron Porphyrin Carbenes and Their Reactivities in N–H Insertion and Related Three-Component ReactionJournal of the American Chemical Society (IF 15.0) Pub Date : 2023-02-22 , DOI:10.1021/jacs.2c12155Chaoqun Ma, Shang Wang, Yuan Sheng, Xiao-Li Zhao, Dong Xing, Wenhao HuIron porphyrin carbenes (IPCs) have been extensively recognized as the reactive intermediates in various iron porphyrin-catalyzed carbene transfer reactions. While donor–acceptor diazo compounds have been frequently used for such transformations, the structures and reactivities of donor–acceptor IPCs are less explored. To date, no crystal structures of donor–acceptor IPC complexes have been reported ...
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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)Signal Transduction and Targeted Therapy (IF 39.3) Pub Date : 2023-02-08 , DOI:10.1038/s41392-022-01235-0Yu-Sheng Song, Chun-Wang Yuan, Wei-Dong Wang, Ming Huang, Wei Zhao, Jian-Bing Wu, Song Wang, Xu Zhu, Jian-Jun Han, Wei-Xin Ren, Zai-Ming Lu, Wen-Ge Xing, Yong Fan, Hai-Lan Lin, Zi-Shu Zhang, Guo-Hui Xu, Wen-Hao Hu, Qiang Tu, Hong-Ying Su, Chuan-Sheng Zheng, Yong Chen, Xu-Ya Zhao, Zhu-Ting Fang, Qi Wang, Jin-Wei Zhao, Ai-Bing Xu, Jian Xu, Qing-Hua Wu, Huan-Zhang Niu, Jian Wang, Feng Dai, Dui-Ping Feng, Qing-Dong
There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC). It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations. In this nationwide, retrospective, cohort study
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A broadband flexible microwave-optical compatible absorberMicrowave and Optical Technology Letters (IF 1.5) Pub Date : 2023-02-06 , DOI:10.1002/mop.33636Meiling Li, Wenhao Hu, Qi Zheng, Xuexia Yang, Zixuan YiIn this paper, a broadband flexible absorber for compatible microwave-optical absorption is proposed. The absorber consists of two polyvinyl chloride (PVC) substrates and three resistive layers made of conductive carbon black (CCB). Two CCB layers are employed as the frequency-selective surface to achieve microwave absorption while the third one ensures high optical absorption. The PVC substrates provide ...
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