- 作 者: ( "jinhao gao" OR "jin-hao gao" )
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An Activatable 19F MRI Molecular Probe for Sensing and Imaging of NorepinephrineChemistryOpen (IF 2.63) Pub Date : 2022-06-28 ,DOI:10.1002/open.202200110Lingxuan Li, Ao Li, Yaying Lin, Dongxia Chen, Bilun Kang, Hongyu Lin, Jinhao GaoThe MOE Laboratory of Spectrochemical Analysis & Instrumentation Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China.
A small-molecular 19F MRI probe (NRFP) was developed by conjugating a fluorine-containing moiety and a paramagnetic Gd chelate through a NE-responsive aromatic thiocarbonate linkage, which allows for detection of NE using 19F NMR/MRI. Its capacity and specificity for sensing and imaging NE have been demonstrated by a series of in vitro, ex vivo, and in vivo experiments.
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Sequence-controlled heterolayered lanthanide-complex dendritic architectures constructed from modular Ln-DOTA derivativesCell Reports Physical Science (IF 7.832) Pub Date : 2022-06-20 ,DOI:10.1016/j.xcrp.2022.100950Zhaoxuan Yang, Chengjie Sun, Yaying Lin, Haojin Lin, Jinhao Gao, Hongyu Lin
Heterometallic lanthanide complexes, especially with specific metal arrays, are attracting special attention due to their unusual physical properties, which have found many applications in various fields, including high-performance molecular optical/magnetic devices and multifunctional probes for bioassays and bioimaging. However, due to the similar chemical properties of lanthanide ions, their construction
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Multinuclear Mn(II) united-DOTA complexes with enhanced inertness and high MRI contrast abilityCell Reports Physical Science (IF 7.832) Pub Date : 2022-06-01 ,DOI:10.1016/j.xcrp.2022.100920Chengjie Sun, Zhaoxuan Yang, Peng Wu, Xiangjie Luo, Kun Liu, Binju Wang, Hongyu Lin, Jinhao Gao
Chelating lability significantly hinders the development of Mn(II)-based magnetic resonance image (MRI) contrast agents. Herein, using 1,4,7,10-tetraazacyclododecane-N,N’,N’’,N’’’-tetraacetic acid (DOTA) as a chelating unit, we show that multinuclear Mn(II) united-DOTA chelates are of up to 69-fold higher inertness than Magnevist, a clinical Gd-based contrast agent. The unusual inertness could be ascribed
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A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapyRSC Chemical Biology Pub Date : 2022-05-30 ,DOI:10.1039/d1cb00257kZhaoxuan Yang, Jiaqi Huang, Yaying Lin, Xiangjie Luo, Haojin Lin, Hongyu Lin, Jinhao GaoFujian Provincial Key Laboratory of Chemical Biology, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University Xiamen 361005 China China
Herein we report a dual-responsive doxorubicin–indoximod conjugate (DOXIND) for programmed chemoimmunotherapy. This conjugate is able to release doxorubicin and indoximod upon exposure to appropriate stimuli for synergistic chemotherapy and immunotherapy, respectively. We demonstrate its promoting effects on immune response and inhibiting effects on tumor growth through a series of in vitro and in
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Photoinduced Superhydrophilicity of Gd-Doped TiO2 Ellipsoidal Nanoparticles Boosts T1 Contrast Enhancement for Magnetic Resonance ImagingNano Letters (IF 12.262) Pub Date : 2022-04-05 ,DOI:10.1021/acs.nanolett.1c04676Kun Liu, Zhongyuan Cai, Xiaoqin Chi, Bilun Kang, Shengxiang Fu, Xiangjie Luo, Zhi-Wei Lin, Hua Ai, Jinhao Gao, Hongyu LinThe unsatisfactory performance of current gadolinium chelate based T1 contrast agents (CAs) for magnetic resonance imaging (MRI) stimulates the search for better alternatives. Herein, we report a new strategy to substantially improve the capacity of nanoparticle-based T1 CAs by exploiting the photoinduced superhydrophilic assistance (PISA) effect. As a proof of concept, we synthesized citrate-coated ...
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Tandem Chemoimmunotherapy by a Cascade-Responsive Molecular ProdrugACS Chemical Biology (IF 4.634) Pub Date : 2022-03-14 ,DOI:10.1021/acschembio.1c00933Zhaoxuan Yang, Xiangjie Luo, Yaying Lin, Jiaqi Huang, Hongyu Lin, Jinhao GaoMOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Fujian Provincial Key Laboratory of Chemical Biology, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.The limited therapeutic effects of immunotherapy for most types of cancer stimulates the pursuit for efficient methods to improve its response rate. Herein we report the design and synthesis of a cascade-responsive molecular prodrug for tandem chemoimmunotherapy. This molecular prodrug first releases doxorubicin (DOX) in the mildly acidic tumor microenvironment (TME) to induce immunogenic cell death ...
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Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T1-Weighted Contrast-Enhanced Brain ImagingACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2022-01-12 ,DOI:10.1021/acsami.1c20617Ruixue Wei, Kun Liu, Ke Zhang, Yifan Fan, Hongyu Lin, Jinhao GaoManganese oxide nanoparticles (NPs) have attracted increasing attention recently as contrast agents (CAs) for magnetic resonance imaging (MRI). However, the clinical translation and popularization of conventional MnO NPs are hampered by their relatively poor imaging performance. Herein, we report the construction of ultrasmall MnO NPs (USMnO) via a one-pot synthetic approach that show a much better ...
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Fluorinated Ionic Liquid Based Multicolor 19F MRI Nanoprobes for In Vivo Sensing of Multiple Biological TargetsAdvanced Healthcare Materials (IF 11.092) Pub Date : 2021-12-13 ,DOI:10.1002/adhm.202102079Xianglong Zhu, Hehe Xiong, Sitian Wang, Yanyan Li, Jingxian Chi, Xuefei Wang, Tiantian Li, Qiuju Zhou, Jinhao Gao, Saige ShiMulticolor imaging, which maps the distribution of different targets, is important for in vivo molecular imaging and clinical diagnosis. Fluorine 19 magnetic resonance imaging (19F MRI) is a promising technique because of unique insights without endogenous background or tissue penetration limit. Thus multicolor 19F MRI probes, which can sense a wide variety of molecular species, are expected to help ...
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Activatable Multiplexed 19F Magnetic Resonance Imaging Visualizes Reactive Oxygen and Nitrogen Species in Drug-Induced Acute Kidney InjuryAnalytical Chemistry (IF 8.008) Pub Date : 2021-12-03 ,DOI:10.1021/acs.analchem.1c03744Ao Li, Xiangjie Luo, Lingxuan Li, Dongxia Chen, Xing Liu, Zhaoxuan Yang, Lijiao Yang, Jinhao Gao, Hongyu LinIn vivo levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) are critical to many physiological and pathological processes. Because of the distinct differences in their biological generation and effects, simultaneously visualizing both of them could help deepen our insights into the mechanistic details of these processes. However, real-time and deep-tissue imaging and differentiation ...
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Arsenite-loaded albumin nanoparticles for targeted synergistic chemo-photothermal therapy of HCCBiomaterials Science (IF 7.59) Pub Date : 2021-11-30 ,DOI:10.1039/d1bm01374bKe Zhang, Dan Li, Bin Zhou, Jiani Liu, Xiangjie Luo, Ruixue Wei, Lizhu Wang, Xiaojun Hu, Zhongzhen Su, Hongyu Lin, Jinhao Gao, Hong ShanArsenic trioxide (ATO, As2O3), an active ingredient of traditional Chinese medicine, has been approved by the U.S. Food and Drug Administration as an effective therapeutic agent for acute promyelocytic leukemia (APL). However, the application of ATO in treating advanced solid tumors like hepatocellular carcinoma (HCC) is still restricted by limited therapeutic efficacy and insufferable side effects ...
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Redox-Activated Contrast-Enhanced T1-Weighted Imaging Visualizes Glutathione-Mediated Biotransformation Dynamics in the LiverACS Nano (IF 18.027) Pub Date : 2021-11-09 ,DOI:10.1021/acsnano.1c06026Kun Liu, Bilun Kang, Xiangjie Luo, Zhaoxuan Yang, Chengjie Sun, Ao Li, Yifan Fan, Xiaoyuan Chen, Jinhao Gao, Hongyu LinGSH-mediated liver biotransformation is a crucial physiological process demanding efficient research tools. Here, we report a type of amorphous FexMnyO nanoparticles (AFMO-ZDS NPs) as redox-activated probes for in vivo visualization of the dynamics of GSH-mediated biotransformation in liver with T1-weighted magnetic resonance imaging (MRI). This imaging technique reveals the periodic variations in ...
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Recent advances in engineering iron oxide nanoparticles for effective magnetic resonance imagingBioactive Materials (IF 16.874) Pub Date : 2021-10-19 ,DOI:10.1016/j.bioactmat.2021.10.014Zhenghuan Zhao, Muyao Li, Jie Zeng, Linlin Huo, Kun Liu, Ruixue Wei, Kaiyuan Ni, Jinhao Gao
Iron oxide nanoparticle (IONP) with unique magnetic property and high biocompatibility have been widely used as magnetic resonance imaging (MRI) contrast agent (CA) for long time. However, a review which comprehensively summarizes the recent development of IONP as traditional T2 CA and its new application for different modality of MRI, such as T1 imaging, simultaneous T2/T1 or MRI/other imaging modality
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A camptothecin prodrug induces mitochondria-mediated apoptosis in cancer cells with cascade activationsChemical Communications (IF 6.065) Pub Date : 2021-09-28 ,DOI:10.1039/d1cc04379jXiangjie Luo, Xiaoqin Chi, Yaying Lin, Zhaoxuan Yang, Hongyu Lin, Jinhao GaoMitochondria are crucial regulators of the intrinsic pathway of apoptosis. Herein, we report a photosensitizer-conjugated camptothecin (CPT)-based prodrug for combinative chemo-photodynamic treatment of solid tumors with cascade activations. Upon light irradiation, our prodrug can effectively target the mitochondria of cancer cells, generate singlet oxygen to increase the level of reactive oxygen species ...
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Deep-tissue real-time imaging of drug-induced liver injury with peroxynitrite-responsive 19F MRI nanoprobesChemical Communications (IF 6.065) Pub Date : 2021-08-25 ,DOI:10.1039/d1cc03913jAo Li, Lingxuan Li, Xing Liu, Dongxia Chen, Yifan Fan, Hongyu Lin, Jinhao GaoThe MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.Peroxynitrite is an important biomarker for assessing drug-induced liver injury (DILI), which is critical for the development and use of drugs. Herein, we report the development of peroxynitrite-responsive self-assembled 19F MRI nanoprobes, which enable the sensitive imaging of peroxynitrite in L02 cells subjected to oxidative stress and living mice with DILI. ...
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Synergistic Enhancement of Fluorescence and Magnetic Resonance Signals Assisted by Albumin Aggregate for Dual-Modal ImagingACS Nano (IF 18.027) Pub Date : 2021-06-07 ,DOI:10.1021/acsnano.1c01251Lirong Wang, Qing Wan, Rongyuan Zhang, Bo Situ, Kaiyuan Ni, Jinhao Gao, Xing Feng, Pengfei Zhang, Zhiming Wang, Anjun Qin, Ben Zhong TangDual-modal fluorescence and magnetic resonance imaging (FLI/MRI) is important for the early diagnosis of malignant tumors. However, facile and opportune strategies to synergistically enhance fluorescence intensity and magnetic resonance (MR) contrast have rarely been reported. Herein, we present a facile strategy using albumin aggregates (AAs) to synergistically enhance the fluorescence intensity by ...
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Data-driven process control for manufacturing spiral bevel and hypoid gears by using design for six sigma (DFSS) considering numerical loaded tooth contact analysis (NLTCA)Proceedings of the Institution of Mechanical Engineers, Part B: Journal of Engineering Manufacture (IF 2.759) Pub Date : 2021-06-04 ,DOI:10.1177/09544054211023625Kaibin Rong,Han Ding,Biyun Song,Jinhao Gao,Jinyuan TangData-driven process control considering both geometric and loaded contact performance evaluations has been an increasingly important stage in field of spiral bevel and hypoid gears. A new data-driven manufacturing process control strategy is proposed for a high performance spiral bevel and hypoid gears. Here, to distinguish with the conventional simulated loaded tooth contact analysis (SLTCA) using ...
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Improving the sensitivity of T1 contrast-enhanced MRI and sensitive diagnosing tumors with ultralow doses of MnO octahedronsTheranostics (IF 11.6) Pub Date : 2021-5-8 ,DOI:10.7150/thno.59096Lijiao Yang, Lili Wang, Guoming Huang, Xuan Zhang, Lanlan Chen, Ao Li, Jinhao Gao, Zijian Zhou, Lichao Su, Huanghao Yang, Jibin Song
Rationale: Sensitive and accurate imaging of cancer is essential for early diagnosis and appropriate treatment. For generally employed magnetic resonance imaging (MRI) in clinic, comprehending how to enhance the contrast effect of T1 imaging is crucial for improving the sensitivity of cancer diagnosis. However, there is no study ever to reveal the clear mechanism of how to enhance the effect of T1
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Hypoxia-Activated Prodrug Enabling Synchronous Chemotherapy and HIF-1α Downregulation for Tumor TreatmentBioconjugate Chemistry (IF 6.069) Pub Date : 2021-04-13 ,DOI:10.1021/acs.bioconjchem.1c00131Xiangjie Luo, Ao Li, Xiaoqin Chi, Yaying Lin, Xing Liu, Lifan Zhang, Xinhui Su, Zhenyu Yin, Hongyu Lin, Jinhao GaoThe overexpression of HIF-1α in solid tumors due to hypoxia is closely related to drug resistance and consequent treatment failure. Herein, we constructed a hypoxia-activated prodrug named as YC-Dox. This prodrug could be activated under hypoxic conditions and undergo self-immolation to release doxorubicin (Dox) and YC-1 hemisuccinate (YCH-1), which could execute chemotherapy and result in HIF-1α downregulation ...
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Activatable 19F MRI Nanoprobes for Visualization of Biological Targets in Living SubjectsAdvanced Materials (IF 32.086) Pub Date : 2021-04-08 ,DOI:10.1002/adma.202005657Hongyu Lin, Xiaoxue Tang, Ao Li, Jinhao GaoState Key Laboratory of Physical Chemistry of Solid Surfaces, The MOE Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.Visualization of biological targets such as crucial cells and biomolecules in living subjects is critical for the studies of important biological processes. Though 1H magnetic resonance imaging (MRI) has demonstrated its power in offering detailed anatomical and pathological information, its capacity for in vivo tracking of biological targets is limited by the high biological background of 1H. 19F ...
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Small functionalized iron oxide nanoparticles for dual brain magnetic resonance imaging and fluorescence imagingRSC Advances (IF 4.036) Pub Date : 2021-4-6 ,DOI:10.1039/d0ra10392fRuixue Wei, Yang Liu, Jinhao Gao, V. Wee Yong, Mengzhou Xue
The diagnosis of brain diseases is the first key step in effective treatment. In vivo imaging tracers that effectively cross the blood–brain barrier (BBB) and reach areas of brain dysregulation is one focus of accurate diagnosis. Here, our main objective was to develop an iron-based nanoparticle for dual brain magnetic resonance imaging (MRI) and fluorescence imaging studies. Small sized iron oxide
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Imaging Beyond Seeing: Early Prognosis of Cancer TreatmentSmall Methods (IF 15.367) Pub Date : 2020-12-18 ,DOI:10.1002/smtd.202001025Changrong Shi, Zijian Zhou, Hongyu Lin, Jinhao GaoAssessing cancer response to therapeutic interventions has been realized as an important course to early predict curative efficacy and treatment outcomes due to tumor heterogeneity. Compared to the traditional invasive tissue biopsy method, molecular imaging techniques have fundamentally revolutionized the ability to evaluate cancer response in a spatiotemporal manner. The past few years has witnessed ...
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Fluorinated Gadolinium Chelate-Grafted Nanoconjugates for Contrast-Enhanced T1-Weighted 1H and pH-Activatable 19F Dual-Modal MRIAnalytical Chemistry (IF 8.008) Pub Date : 2020-11-30 ,DOI:10.1021/acs.analchem.0c04296Xiaoxue Tang, Xuanqing Gong, Jiang Ming, Dongxia Chen, Hongyu Lin, Jinhao GaoThe Key Laboratory for Chemical Biology of Fujian Province, The MOE Laboratory of Spectrochemical Analysis & Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinaMagnetic resonance imaging (MRI) is one of the most popular imaging techniques, which offers an ionization-free noninvasive means for imaging deep tissues with high resolution. Conventional 1H MRI is well versed in providing detailed anatomical information but suffers from low contrast for tracking biomarkers because of the abundance of water in living bodies. 19F MRI with negligible endogenous background ...
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Activatable Mitochondria‐Targeting Organoarsenic Prodrugs for Bioenergetic Cancer TherapyAngewandte Chemie International Edition (IF 16.823) Pub Date : 2020-10-07 ,DOI:10.1002/anie.202012237Xiangjie Luo, Xuanqing Gong, Liyun Su, Hongyu Lin, Zhaoxuan Yang, Xiaomei Yan, Jinhao GaoDepartment of Chemical Biology The MOE Laboratory of Spectrochemical Analysis & Instrumentation, and the Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 ChinaDespite widespread applications for cancer treatment, chemotherapy is restricted by several limitations, including low targeting specificity, acquired drug resistance, and concomitant adverse side effects. It remains challenging to overcome these drawbacks. Herein, we report a new bioenergetic approach for treating cancer efficiently. As a proof‐of‐concept, we construct activatable mitochondria‐targeting ...
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Enhancing Chemotherapy of p53‐Mutated Cancer through Ubiquitination‐Dependent Proteasomal Degradation of Mutant p53 Proteins by Engineered ZnFe‐4 NanoparticlesAdvanced Functional Materials (IF 19.924) Pub Date : 2020-08-17 ,DOI:10.1002/adfm.202001994Jieying Qian, Wenbin Zhang, Pengfei Wei, Guangyu Yao, Tianxiang Yi, Hao Zhang, He Ding, Xiaowan Huang, Meimei Wang, Yang Song, Suqin Zhong, Lijiao Yang, Jinhao Gao, Zijian Zhou, Long‐ping Wen, Yunjiao ZhangA significant percentage of human cancers harbor missense mutations in the TP53 gene and express highly stabilized mutant p53 protein (mutp53) with tumor‐promoting gain‐of‐function (GOF) properties. Inducing mutp53 degradation is a viable precision anti‐tumor therapeutic strategy. Based on the previously reported finding that a zinc‐curcumin compound induced mutp53 degradation, a series of ZnFe nanoparticles ...
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An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticlesAutophagy (IF 13.391) Pub Date : 2020-05-23 ,DOI:10.1080/15548627.2020.1763019Chen Ruan, Chenwei Wang, Xuanqing Gong, Ying Zhang, Wankun Deng, Jiaqi Zhou, Dengtong Huang, Zining Wang, Qiong Zhang, Anyuan Guo, Jiahong Lu, Jinhao Gao, Di Peng, Yu XueABSTRACT Dysfunction of macroautophagy/autophagy has been postulated as a major cellular toxicological response to nanomaterials. It has been reported that excessive autophagy activation, induced by silica nanoparticles (SiNPs), contributes to autophagy dysfunction, whereas little is known how SiNPs trigger autophagy activation. Here, we treated normal rat kidney (NRK) cells using 3 different sizes ...
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Recent advances of nanomedicines for liver cancer therapy.Journal of Materials Chemistry B (IF 7.571) Pub Date : 2020-05-06 ,DOI:10.1039/c9tb02871dXiaoqin Chi,Kun Liu,Xiangjie Luo,Zhenyu Yin,Hongyu Lin,Jinhao GaoFujian Provincial Key Laboratory of Chronic Liver Disease and Hepatocellular Carcinoma, Zhongshan Hospital, Xiamen University, Xiamen 361004, China. and The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, ChinaLiver cancer is one of the most prevalent cancers and the third leading cause of cancer-related deaths worldwide. Liver cancer is insensitive to chemotherapeutic drugs due to its intrinsic or acquired drug resistance and the inability of delivering sufficient drugs to tumors via current chemotherapy. The emergence of nanomedicines offers a potential solution for this challenge. Nanomedicines utilize ...
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A Fluorinated Ionic Liquid-Based Activatable 19F MRI Platform Detects Biological TargetsChem (IF 25.832) Pub Date : 2020-02-24 ,DOI:10.1016/j.chempr.2020.01.023Xianglong Zhu, Xiaoxue Tang, Hongyu Lin, Saige Shi, Hehe Xiong, Qiuju Zhou, Ao Li, Qiaoyang Wang, Xiaoyuan Chen, Jinhao Gao19F magnetic resonance imaging (19F MRI) is a promising technique for in vivo molecular imaging and clinical diagnosis, benefiting from its negligible background and unlimited tissue penetration depth. However, the development of 19F probes with good water solubility and versatile functions for bioresponsive and practical applications remains a challenge. Here, we report fluorinated ion liquids (ILs) ...
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Cascaded Multiresponsive Self-Assembled 19F MRI Nanoprobes with Redox-Triggered Activation and NIR-Induced Amplification.Nano Letters (IF 12.262) Pub Date : 2019-12-16 ,DOI:10.1021/acs.nanolett.9b04016Xiaoxue Tang,Xuanqing Gong,Ao Li,Hongyu Lin,Chenyu Peng,Xianzhong Zhang,Xiaoyuan Chen,Jinhao GaoMolecular probes featuring promising capabilities including specific targeting, high signal-to-noise ratio, and in situ visualization of deep tissues are in great demand for tumor diagnosis and therapy. 19F magnetic resonance imaging (MRI) techniques incorporating stimuli-responsive probes are anticipated to be highly beneficial for specific detection and imaging of tumors because of negligible background ...
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DOTA-Branched Organic Frameworks as Giant and Potent Metal ChelatorsJournal of the American Chemical Society (IF 16.383) Pub Date : 2019-12-11 ,DOI:10.1021/jacs.9b09269Chengjie Sun, Hongyu Lin, Xuanqing Gong, Zhaoxuan Yang, Yan Mo, Xiaoyuan Chen, Jinhao GaoMultinuclear complexes as metallo-agents for clinical use have caught extensive attention. In this paper, using DOTA as both a functioning unit and a constructing junction, we build a series of DOTA-branched organic frameworks (DBOF) with multiple chelating holes by organizing DOTA layer by layer. These giant chelators are well characterized, which re-veals their nano-sized and soft structures. Further ...
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Properties of a novel imbibition polymer with ultra-high wetting ability as a fracturing fluid system†New Journal of Chemistry (IF 3.925) Pub Date : 2019-11-28 ,DOI:10.1039/c9nj03515jJinhao Gao, Guanghua Zhang, Lei Wang, Xiaojia Xue, Li Ding, Xianwen Li, Xiaojuan Lai, Chuanqing HuangA novel fracturing fluid system with wettability was prepared. XRD and TGA of the polymer were measured. Rheology and SEM experiments showed that the fracturing fluid had a dense network structure. The microstructures of the gel breaking fluid were obtained using SEM and TEM tests, which demonstrated more obvious crosslinking. Contact angle and wetting function of the gel breaking fluid were evaluated ...
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