- 作 者: "qin zhang"
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Breed identification using breed-informative SNPs and machine learning based on whole genome sequence data and SNP chip dataJournal of Animal Science and Biotechnology (IF 6.175) Pub Date : 2023-06-01 ,DOI:10.1186/s40104-023-00880-xChangheng Zhao, Dan Wang, Jun Teng, Cheng Yang, Xinyi Zhang, Xianming Wei, Qin Zhang
Breed identification is useful in a variety of biological contexts. Breed identification usually involves two stages, i.e., detection of breed-informative SNPs and breed assignment. For both stages, there are several methods proposed. However, what is the optimal combination of these methods remain unclear. In this study, using the whole genome sequence data available for 13 cattle breeds from Run
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Relief of ovalbumin-induced airway remodeling by the glycyl-l-histidyl-l-lysine-Cu2+ tripeptide complex via activation of SIRT1 in airway epithelial cellsBiomedicine & Pharmacotherapy (IF 7.419) Pub Date : 2023-05-29 ,DOI:10.1016/j.biopha.2023.114936Qin Zhang, Jia Liu, Ming-ming Deng, Run Tong, Gang HouFixed airflow limitation (FAO), prevalent in patients with severe or difficult-to-treat asthma, is mainly caused by airway remodeling. Airway remodeling is initiated by inflammation and involves subsequent pathological changes. Glycyl-l-histidyl-l-lysine (GHK) is a matrikine with anti-inflammatory and antioxidant effects, naturally existing in human tissue. At present, the GHK level in human plasma ...
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Query-Policy Misalignment in Preference-Based Reinforcement LearningarXiv - CS - Machine Learning Pub Date : 2023-05-27 ,DOI:arxiv-2305.17400Xiao Hu, Jianxiong Li, Xianyuan Zhan, Qing-Shan Jia, Ya-Qin ZhangPreference-based reinforcement learning (PbRL) provides a natural way to align RL agents' behavior with human desired outcomes, but is often restrained by costly human feedback. To improve feedback efficiency, most existing PbRL methods focus on selecting queries to maximally improve the overall quality of the reward model, but counter-intuitively, we find that this may not necessarily lead to improved ...
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Improving gel properties of soy protein isolate through alkaline pH-shifting, mild heat treatment, and TGase cross-linkingFood Hydrocolloids (IF 11.504) Pub Date : 2023-05-26 ,DOI:10.1016/j.foodhyd.2023.108924Ping Sun, Qin Zhang, Yu Zhao, Dongshun Zhao, Xiaohui Zhao, Lianzhou Jiang, Yan Zhang, Fei Wu, Xiaonan SuiImproving the functional properties of soybean protein isolate (SPI) is essential for expanding its applications in food-related fields, given its poor solubility and gelation. This study investigated the effect of alkaline pH-shifting and mild heating on the structure of SPI, as well as the gel properties after TGase cross-linking. Solubility of SPI increased with increasing alkalinity from pH 7.0 ...
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Facile fabrication of microstructure-tunable aluminum-based metal–organic frameworks for exceptional phosphorus recovery from waterJournal of Molecular Liquids (IF 6.633) Pub Date : 2023-05-25 ,DOI:10.1016/j.molliq.2023.122163Qin Zhang, Yujie Jiao, Peng Kang, Qipeng Li, Jiankang Gong, Zhongxia Zhao, Lang Li, Banglei Zhang, Shengjian Li, Xiangjun YangThe recovery of phosphorus from phosphorus-contaminated water is of great significance to prevent the eutrophication of natural water and overcome the shortage of phosphorus resources. To increase the effectiveness of phosphorus removal from water, aluminum metal–organic frameworks (Al-MOFs) with different microstructures were synthesized in this study by varying the ratio of metal centers (Al) to ...
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PROTO: Iterative Policy Regularized Offline-to-Online Reinforcement LearningarXiv - CS - Robotics Pub Date : 2023-05-25 ,DOI:arxiv-2305.15669Jianxiong Li, Xiao Hu, Haoran Xu, Jingjing Liu, Xianyuan Zhan, Ya-Qin ZhangOffline-to-online reinforcement learning (RL), by combining the benefits of offline pretraining and online finetuning, promises enhanced sample efficiency and policy performance. However, existing methods, effective as they are, suffer from suboptimal performance, limited adaptability, and unsatisfactory computational efficiency. We propose a novel framework, PROTO, which overcomes the aforementioned ...
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PROTO: Iterative Policy Regularized Offline-to-Online Reinforcement LearningarXiv - CS - Machine Learning Pub Date : 2023-05-25 ,DOI:arxiv-2305.15669Jianxiong Li, Xiao Hu, Haoran Xu, Jingjing Liu, Xianyuan Zhan, Ya-Qin ZhangOffline-to-online reinforcement learning (RL), by combining the benefits of offline pretraining and online finetuning, promises enhanced sample efficiency and policy performance. However, existing methods, effective as they are, suffer from suboptimal performance, limited adaptability, and unsatisfactory computational efficiency. We propose a novel framework, PROTO, which overcomes the aforementioned ...
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PROTO: Iterative Policy Regularized Offline-to-Online Reinforcement LearningarXiv - CS - Artificial Intelligence Pub Date : 2023-05-25 ,DOI:arxiv-2305.15669Jianxiong Li, Xiao Hu, Haoran Xu, Jingjing Liu, Xianyuan Zhan, Ya-Qin ZhangOffline-to-online reinforcement learning (RL), by combining the benefits of offline pretraining and online finetuning, promises enhanced sample efficiency and policy performance. However, existing methods, effective as they are, suffer from suboptimal performance, limited adaptability, and unsatisfactory computational efficiency. We propose a novel framework, PROTO, which overcomes the aforementioned ...
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Acceptor/π-bridge planarization and donor rotation manipulation for designing an NIR-II AIEgen with high photothermal conversion efficiency to enhance cancer phototherapyChemical Engineering Journal (IF 16.744) Pub Date : 2023-05-25 ,DOI:10.1016/j.cej.2023.143726Hongyan Shen, Binbin Wu, Qin Zhang, Jiahao Ni, Manshan Liang, Yanlong Liu, Xu-Feng Zang, Shihua Wang, Yun-Yun Quan, Xiaoxia Ye, Zu-Sheng HuangAggregation-induced emission luminogens (AIEgens) with second near infrared (NIR-II) fluorescence and photothermal therapy (PTT) have recently attracted great research interest. The formidable challenge, the competing balance between radiation-mediated NIR-II fluorescence imaging and non-radiation NIR-PTT, prevents the development of efficient NIR-II AIEgens. In this study, a quite strong photothermal ...
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DsbA-L alleviated tubular injury in diabetic nephropathy via activating mitophagy through maintain MAM integrity.Clinical Science Pub Date : 2023-05-25 ,DOI:10.1042/cs20220787Lin Sun,Ming Yang,Qin Zhang,Shilu Luo,Yachun Han,Hao Zhao,Na Jiang,Yan Liu,Li Li,Chenrui Li,Chongbin Liu,Liyu He,Xuejing Zhu,Yu Liu
Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate ATG14- and Beclin1-mediated mitophagy and play key roles in the development of diabetic nephropathy (DN). DsbA-L is mainly located in MAMs and plays a role in renoprotection, but whether it activates mitophagy by maintaining MAM integrity remains unclear. In this study, we found that renal tubular damage was further aggravated
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High crystallinity makes excellent wear resistance in crosslinked UHMWPEPolymer (IF 4.432) Pub Date : 2023-05-24 ,DOI:10.1016/j.polymer.2023.126059Zirui Wang, Quan Li, Xianchun Chen, Qin Zhang, Ke WangNowadays, irradiation crosslinking is still a primary method to improve the wear resistance of ultrahigh molecular weight polyethylene (UHMWPE). As a semi-crystalline polymer, crystalline structure of UHMWPE will also significantly affect the abrasion performance. Due to the difficulty in obtaining a wide range of crystallinity (Xc), there is less knowledge on the synergistic enhancement of crosslinking ...
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Observation of Enantiomeric Switching of Individual Plasmonic MetamoleculesNano Letters (IF 12.262) Pub Date : 2023-05-24 ,DOI:10.1021/acs.nanolett.3c01159Qin Zhang, Xiaoyao Wang, Huiying Wu, Jinjin Zhang, Xingyue Lin, Jiaoyang Sa, Hao Li, Chao Zhou, Weihai NiActive plasmonic metamolecules under microscopic observation are promising for optical reporters in single molecule sensing applications. While self-assembled reconfigurable chiral plasmonic metamolecules can be conveniently engineered with sensing functionalities, their observation is usually based on ensemble measurements, where the chiroptical response of enantiomers tend to cancel each other in ...
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Estrogen-sensitive activation of SGK1 induces M2 macrophages with anti-inflammatory properties and a Th2 response at the maternal–fetal interfaceReproductive Biology and Endocrinology (IF 4.982) Pub Date : 2023-05-24 ,DOI:10.1186/s12958-023-01102-9Yiyun Lou, Zhujing Fu, Ye Tian, Minhao Hu, Qijing Wang, Yuanyuan Zhou, Ning Wang, Qin Zhang, Fan Jin
Decidual macrophages participate in immune regulation at the maternal–fetal interface. Abnormal M1/M2 polarization of decidual macrophages might predispose immune maladaptation in recurrent pregnancy loss (RPL). However, the mechanism of decidual macrophage polarization is unclear. We explored the role of Estradiol (E2)-sensitive serum-glucocorticoid regulated kinase (SGK) 1 in promoting macrophage
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Trace Detection of Chiral J-aggregated Molecules Adsorbed on Single Au NanorodsNanoscale (IF 8.307) Pub Date : 2023-05-23 ,DOI:10.1039/d3nr01147jXingyue Lin, Yuhan Zhou, Xinyang Pan, Qin Zhang, Ningneng Hu, Hao Li, Le Wang, Qi Xue, Wei Zhang, Weihai NiTrace detection of chiral molecules, which is of great significance in chemical, biological, medical, and pharmaceutical sciences, requires microscopic techniques at single-particle or -molecule level. Although ensemble experiments show the circular dichroism of the chiral molecules can be amplified by plasmonic nanocrystals, trace detection of small chiral molecules remains challenging due to weak ...
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Nematode-induced trap formation regulated by the histone H3K4 methyltransferase AoSET1 in the nematode-trapping fungus Arthrobotrys oligosporaScience China Life Sciences Pub Date : 2023-05-23 ,DOI:10.1007/s11427-022-2300-2Qiao Miao, Zhengqi Wang, Ziyu Yin, Xiaoying Liu, Ran Li, Ke-Qin Zhang, Juan LiThe methylation of lysine 4 of histone H3 (H3K4), catalyzed by the histone methyltransferase KMT2/SET1, has been functionally identified in many pathogenic fungi but remains unexplored in nematode-trapping fungi (NTFs). Here, we report a regulatory mechanism of an H3K4-specific SET1 orthologue, AoSET1, in the typical nematode-trapping fungus Arthrobotrys oligospora. When the fungus is induced by the ...
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An ultrafast phototrigger of the Trp5CN–Trp motif in a β-hairpin peptideThe Journal of Chemical Physics (IF 4.304) Pub Date : 2023-05-22 ,DOI:10.1063/5.0143384Qin Zhang, Zhongneng Zhou, Bodan Deng, Bingyao Wang, Xiu-Wen Kang, Jinquan Chen, Bei Ding, Dongping Zhong
Phototriggers are useful molecular tools to initiate reactions in enzymes by light for the purpose of photoenzymatic design and mechanistic investigations. Here, we incorporated the non-natural amino acid 5-cyanotryptophan (W5CN) in a polypeptide scaffold and resolved the photochemical reaction of the W5CN–W motif using femtosecond transient UV/Vis and mid-IR spectroscopy. We identified a marker band
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Highly synergistic and polarized KNbO3/WO3 heterojunction for piezo-photocatalytic degradation of organic pollutantJournal of Environmental Chemical Engineering (IF 7.968) Pub Date : 2023-05-22 ,DOI:10.1016/j.jece.2023.110177Rui Huang, Wei Cai, Heng Zhang, Zhenhua Wang, Qin Zhang, Rongli Gao, Gang Chen, Xiaoling Deng, Xiang Lei, Jiling Dong, Xiaoyan Liu, Chunlin FuThe superior piezo-photocatalytic performances of KNbO3-based materials were achieved by the enhanced photo-induced carrier separation and migration based on the effective strategies of heterojunction construction and polarization engineering. A KNbO3/WO3 type-II heterojunction was fabricated by an impregnation-calcination method, and its outstanding piezo-photocatalytic performance was demonstrated ...
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Oncostatin M regulates macrophages polarization in osseointegration via yes-associated proteinInternational Immunopharmacology (IF 5.714) Pub Date : 2023-05-21 ,DOI:10.1016/j.intimp.2023.110348Ying Yuan, Qin Zhang, Bingfeng Wu, Tianyu Huang, Ping Gong, Lin XiangObjectives Oncostatin M(OSM), secreted by monocytes and macrophages, has been noted to participate in bone homeostasis and macrophage polarization, which might be regulated by yes-associated protein (YAP). This study aimed to elucidate the influence and mechanisms of OSM-YAP on macrophages polarization in osseointegration. Material and methods In vitro, flow cytometry, real-time PCR, and Elisa were ...
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Boosting the photoelectrochemical performance of bismuth vanadate photoanode through homojunction constructionJournal of Colloid and Interface Science (IF 9.965) Pub Date : 2023-05-19 ,DOI:10.1016/j.jcis.2023.05.097Haipeng Wang, Shuyun Wang, May Thawda Oo, Yuewen Yang, Jiasheng Zhou, Miaoyan Huang, Rui-Qin ZhangThe photoelectrochemical (PEC) performance of bismuth vanadate (BiVO4) suffers from sluggish charge mobility and substantial charge recombination losses due to its intrinsic defect. To rectify the problem, we developed a novel approach to prepare an n-n+ type II BVOac-BVOal homojunction with staggered band alignment. This architecture involves a built-in electric field that facilitating the electron-hole ...
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Real-time high-precision landslide displacement monitoring based on a GNSS CORS networkMeasurement (IF 5.131) Pub Date : 2023-05-19 ,DOI:10.1016/j.measurement.2023.113056Bao Shu, Yuanhao He, Li Wang, Qin Zhang, Xinrui Li, Xuanyu Qu, Guanwen Huang, Wei QuGNSS technology is an effective all-weather, continuous and real-time method of detecting three-dimensional landslide displacement. However, current positioning methods such as the network real-time kinematic (RTK) technique based on virtual reference station (VRS) technology have some limitations, particularly a sensitivity to atmospheric modeling error. In this study, taking advantage of existing ...
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Learning for Open-World Calibration with Graph Neural NetworksarXiv - CS - Computer Vision and Pattern Recognition Pub Date : 2023-05-19 ,DOI:arxiv-2305.12039Qin Zhang, Dongsheng An, Tianjun Xiao, Tong He, Qingming Tang, Ying Nian Wu, Joseph Tighe, Yifan XingWe tackle the problem of threshold calibration for open-world recognition by incorporating representation compactness measures into clustering. Unlike the open-set recognition which focuses on discovering and rejecting the unknown, open-world recognition learns robust representations that are generalizable to disjoint unknown classes at test time. Our proposed method is based on two key observations: ...
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Evidence-based complementary and alternative medicine conventional surgery combined with traditional Chinese medicinal retention enema for tubal obstructive infertility: A systematic review and meta-analysis.PLOS ONE (IF 3.752) Pub Date : 2023-05-18 ,DOI:10.1371/journal.pone.0285859Sijia Xu,Shuo Jin,Liuqing Yang,Ling Wang,Qin Zhang
BACKGROUND Chinese medicinal retention enemas have gradually attracted the attention of clinicians as an alternative approach for tubal obstructive infertility. The purpose of this study was to investigate the efficacy and safety of conventional surgery combined with traditional Chinese medicinal retention enemas for the treatment of tubal obstructive infertility. MATERIALS AND METHODS Eight electronic
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Feasibility of the Omaha system for the care of children with dilated cardiomyopathyFrontiers in Pediatrics (IF 3.569) Pub Date : 2023-05-16 ,DOI:10.3389/fped.2023.1136663Qin Zhang, Ai Zhang, Yanqin Wang, Tiewei Lv, Ping Sun, Xiaoxia Zhao, Rui Li, Xianlan ZhengAim: To explore the feasibility of Omaha system theory in the care of children with dilated cardiomyopathy (DCM), which may provide a practical basis for the continuous nursing of DCM children. Methods: A total of 1,392 records describing symptoms, signs, and nursing interventions were extracted from the medical records of 76 children suffered from DCM. Content analysis method was used to find out ...
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Clinical characters and influence factors of immune checkpoint inhibitor related thyroid dysfunction.The Journal of Clinical Endocrinology & Metabolism (IF 6.134) Pub Date : 2023-05-15 ,DOI:10.1210/clinem/dgad260Qin Zhang,Xiaojuan Jiao,Xiaoyang Lai
CONTEXT Explore the clinical characteristics and influencing factors of immune thyroid dysfunction (ITD) caused by immune checkpoint inhibitors (ICIs) in the treatment of malignant tumors. METHODS This was a retrospective study of cancer patients treated with ICIs between January 2019 and December 2021 at the Second Affiliated Hospital of Nanchang University. According to the occurrence of thyroid
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Clinical efficacy of laparoscopic closed hernia ring combined with a patch repair for Gilbert type III indirect inguinal herniaFrontiers in Surgery (IF 2.568) Pub Date : 2023-05-15 ,DOI:10.3389/fsurg.2023.1190788Luo Binyu, Zhang Qin, Zhang Xiao, Zhang Daquan, Guo Qing, Yu Jing, Tian Yunhong, Ren Mingyang
PurposeThe incidence of seroma and postoperative pain after Gilbert type III inguinal hernia repair is high. To reduce postoperative complications, this study investigated the clinical efficacy of laparoscopic closed hernia ring combined with a patch repair for Gilbert type III indirect inguinal hernia.MethodsThrough a prospective randomized controlled study, a total of 193 patients with Gilbert type
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BDS Orbit Maneuver Detection Based on Epoch-Updated Orbits Estimated by SRIFRemote Sensing (IF 5.349) Pub Date : 2023-05-13 ,DOI:10.3390/rs15102558Zhiwei Qin, Qin Zhang, Guanwen Huang, Longjiang Tang, Jungang Wang, Xiaolei Wang
The orbit maneuver detection is crucial in Global Navigation Satellite System (GNSS) precise orbit determination, which is necessary for adjusting data processing strategies. The frequency of orbit maneuvers for the BeiDou Navigation System is significantly higher than that of other navigation systems, especially for geosynchronous orbit (GEO) and inclined geosynchronous orbit (IGSO) satellites. We
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Characterization of a β-γ coincidence system comprising a plastic scintillator and HPGe detector for radioxenon measurements under the CTBTNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment (IF 1.335) Pub Date : 2023-05-12 ,DOI:10.1016/j.nima.2023.168358Qi Li, Yun-Gang Zhao, Yuan-Qing Fan, Shi-Lian Wang, Huai-Mao Jia, Xin-Jun Zhang, Rui-Qin Zhang, Ya-Zhou Niu, Rui-Ying LiMeasurement of the four relevant radioxenon isotopes, namely 131mXe, 133mXe, 133Xe, and 135Xe, play a key role in underground nuclear explosion monitoring for ensuring compliance with the Comprehensive Nuclear-Test-Ban Treaty (CTBT). A β-γ coincidence system that employs a plastic scintillator detector and a HPGe detector was developed in Beijing Radionuclide Laboratory. The Minimum Detectable Activity ...
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Mott–Schottky Effect in Core–Shell W@WxC Heterostructure: Boosting Both Electronic/Ionic Kinetics for Lithium StorageSmall (IF 15.153) Pub Date : 2023-05-11 ,DOI:10.1002/smll.202300955Yao Yang, Bing Sun, Yinhong Gao, Hui Zhu, Yongting Chen, Xuanke Li, Qin ZhangThe dynamics rate of traditional metal carbides (TMCs) is relatively slow, severely limiting its fast-charging capacity for lithium-ion batteries (LIBs). Herein, the core–shell W@WxC heterostructure is developed to form Mott–Schottky heterostructure, thereby simultaneously accelerating the electronic and ionic transport kinetics during the charging/discharging process. The W nanoparticles are partially ...
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Projecting Global Drought Risk Under Various SSP-RCP ScenariosEarth's Future (IF 8.852) Pub Date : 2023-05-11 ,DOI:10.1029/2022ef003420Zhiling Zhou, Liping Zhang, Jie Chen, Dunxian She, Gangsheng Wang, Qin Zhang, Jun Xia, Yanjun Zhang
Drought risk assessment can identify high-risk areas and bridge the gap between impacts and adaptation. It is thus vital to investigate changes in drought risk and exposed social economy under climate change. Here, the future global meteorological drought risk is projected for the 2021–2100 period under four combined scenarios of Representative Concentration Pathways and Shared Socioeconomic Pathways
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Role of Fibrinogen in Type-2 Diabetes Mellitus with Diabetic Neuropathy and its Preliminary MechanismProtein & Peptide Letters (IF 1.927) Pub Date : 2023-05-11 ,DOI:10.2174/0929866530666230509140515Li Wei, Wei- Li Gu, Zhen-Hong Li, Si-Qin Zhang, Pian Ao, Xiao-Bei Zhu, Xin Zhao, Xin-Yue Zhang, Deng-Feng Zhang, Xiao-Juan Huang, Yu JiangIntroduction: Diabetic peripheral neuropathy (DN) is the most common complication of type 2 diabetes mellitus (T2DM). Objective: This study aimed to explore the role of fibrinogen (FIB) in T2DM neuropathy and its preliminary mechanism. Methods: Ten male Sprague–Dawley rats were divided into a normal control group (NC group) and a T2DM neuropathy model group (DN group). The DN group was given a high-energy ...
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