- 作 者: ( "yuhui sun" OR "yu-hui sun" )
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Dissection of 3D chromosome organization in Streptomyces coelicolor A3(2) leads to biosynthetic gene cluster overexpressionProceedings of the National Academy of Sciences of the United States of America (IF 12.779) Pub Date : 2023-03-06 ,DOI:10.1073/pnas.2222045120Liang Deng, Zhihu Zhao, Lin Liu, Zhiyu Zhong, Wenxinyu Xie, Fan Zhou, Wei Xu, Yubo Zhang, Zixin Deng, Yuhui Sun
The soil-dwelling filamentous bacteria, Streptomyces, is widely known for its ability to produce numerous bioactive natural products. Despite many efforts toward their overproduction and reconstitution, our limited understanding of the relationship between the host’s chromosome three dimension (3D) structure and the yield of the natural products escaped notice. Here, we report the 3D chromosome organization
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A durable and environmental friendly superhydrophobic coatings with self-cleaning, anti-fouling performance for liquid-food residue reductionPolymer Engineering and Science (IF 2.573) Pub Date : 2023-02-22 ,DOI:10.1002/pen.26282Yingchun Sun, Ru Liu, Jianfeng Xu, Yuhui Sun, Jingya Gong, Ling LongA durable and environmentally-friendly superhydrophobic coatings for liquid-food residue reduction were prepared by using stearic acid (SA) modified organic montmorillonite (SA@OMMT) and poly(dimethylsiloxane) (PDMS). Due to the natural hydrophobicity of SAs, SA@OMMT provides low surface energy as well as roughness for the coating. PDMS not only provided low surface energy in the coating but also contributed ...
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Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognitionNature Communications (IF 17.694) Pub Date : 2023-02-04 ,DOI:10.1038/s41467-023-36213-9Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F. Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun
Modular polyketide synthase (PKS) is an ingenious core machine that catalyzes abundant polyketides in nature. Exploring interactions among modules in PKS is very important for understanding the overall biosynthetic process and for engineering PKS assembly-lines. Here, we show that intermodular recognition between the enoylreductase domain ER1/2 inside module 1/2 and the ketosynthase domain KS3 inside
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Mobile and Self-Sustained Data Storage in an Extremophile Genomic DNAAdvanced Science (IF 17.521) Pub Date : 2023-02-03 ,DOI:10.1002/advs.202206201Fajia Sun, Yiming Dong, Ming Ni, Zhi Ping, Yuhui Sun, Qi Ouyang, Long QianDNA has been pursued as a novel biomaterial for digital data storage. While large-scale data storage and random access have been achieved in DNA oligonucleotide pools, repeated data accessing requires constant data replenishment, and these implementations are confined in professional facilities. Here, a mobile data storage system in the genome of the extremophile Halomonas bluephagenesis, which enables ...
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Clustered Embedding Learning for Recommender SystemsarXiv - CS - Machine Learning Pub Date : 2023-02-03 ,DOI:arxiv-2302.01478Yizhou Chen, Guangda Huzhang, Anxiang Zeng, Qingtao Yu, Hui Sun, Hengyi Li, Jingyi Li, Yabo Ni, Han Yu, Zhiming ZhouIn recent years, recommender systems have advanced rapidly, where embedding learning for users and items plays a critical role. A standard method learns a unique embedding vector for each user and item. However, such a method has two important limitations in real-world applications: 1) it is hard to learn embeddings that generalize well for users and items with rare interactions on their own; and 2) ...
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Clustered Embedding Learning for Recommender SystemsarXiv - CS - Artificial Intelligence Pub Date : 2023-02-03 ,DOI:arxiv-2302.01478Yizhou Chen, Guangda Huzhang, Anxiang Zeng, Qingtao Yu, Hui Sun, Hengyi Li, Jingyi Li, Yabo Ni, Han Yu, Zhiming ZhouIn recent years, recommender systems have advanced rapidly, where embedding learning for users and items plays a critical role. A standard method learns a unique embedding vector for each user and item. However, such a method has two important limitations in real-world applications: 1) it is hard to learn embeddings that generalize well for users and items with rare interactions on their own; and 2) ...
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Understanding data governance requirements in IoT adoption for smart ports – a gap analysisMaritime Policy & Management Pub Date : 2022-12-10 ,DOI:10.1080/03088839.2022.2155318Jing Gao, Yuhui Sun, Rameez Rameezdeen, Christopher ChowABSTRACT Maritime shipping is considered the backbone of the global supply chain. It is expected that future fully automated smart ports will be data-driven, harvesting power from advanced analytics and artificial intelligence. Under the hood, Internet of Things (IoT) technologies are considered as an enabling foundation of new data sources for innovations and high-level automation. Thus, enterprise ...
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Role of stress on creep behaviors for MarM247LC DS superalloyFatigue & Fracture of Engineering Materials & Structures (IF 3.373) Pub Date : 2022-12-01 ,DOI:10.1111/ffe.13901Zhenhuan Gao, Yuhui Sun, Nan Liu, Xitao Wang, Jinshan HeRole of stress on creep behaviors of MarM247LC directional-solidified superalloy was investigated at 900°C under different stresses. With reduced stress from 400 MPa to 230 MPa, the creep life has increased by a factor of 24, from 54 h to 1351 h. Apart from that, the deformation mechanism, creep curves, and fracture behavior of the alloy also presented strong dependence on stress. It found that the ...
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Approximation algorithms for some min–max and minimum stacker crane cover problemsJournal of Combinatorial Optimization (IF 1.262) Pub Date : 2022-11-27 ,DOI:10.1007/s10878-022-00955-xYuhui Sun, Wei Yu, Zhaohui LiuWe study two stacker crane cover problems and their variants. Given a mixed graph \(G=(V,E,A)\) with vertex set V, edge set E and arc set A, each edge or arc is associated with a nonnegative weight. The min–max stacker crane cover problem (SCCP) aims to find at most k closed walks covering all the arcs in A such that the maximum weight of the closed walks is minimum. The minimum stacker crane cover ...
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Axial Compression Behaviors of Columns Fabricated from Bamboo Oriented Strand BoardsForests (IF 3.282) Pub Date : 2022-10-31 ,DOI:10.3390/f13111817Yuhui Sun, Jingya Gong, Huanrong Liu, Changhua Fang
Due to the low specific strength of bamboo oriented strand boards compared with the commonly used wooden building materials, reasonable and novel cross-section designs of bamboo columns fabricated from bamboo oriented strand boards as structural members were investigated. An axial compression experiment was carried out on full-scale bamboo columns to characterize the ultimate behaviors under a concentric
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Sevoflurane induces microRNA-18a to delay rat neurodevelopment via suppression of the RUNX1/Wnt/β-catenin axisCell Death Discovery (IF 7.109) Pub Date : 2022-10-01 ,DOI:10.1038/s41420-022-01179-yYuge Jiang, Yaobo Liu, Yuhui Sun, Yongzhe Liu, Long Feng, Mingda Duan, Yi Liu, Longhe Xu
Sevoflurane anesthesia is reported to repress neurogenesis of neural stem cells (NSCs), thereby affecting the brain development, but the underlying mechanism of sevoflurane on the proliferation of NSCs remains unclear. Thus, this study aims to discern the relationship between sevoflurane and NSC proliferation. Bioinformatics tools were employed to predict the expression of microRNA-18a (miR-18a) in
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Development and validation of a prognostic risk signature for lung adenocarcinoma constructed by six ferroptosis, necroptosis, and pyroptosis-related lncRNAs.Journal of Thoracic Disease Pub Date : 2022-10-01 ,DOI:10.21037/jtd-22-1151Lei Peng,Jingbin Ji,Chenyu Zhang,Zhe Wu,Yuhui Sun,Kun Fan,Wenxing Du,Ao Liu,Wenjie Jiao
Background Identifying populations that benefit from immune checkpoint blockade (ICB) therapy remains a major challenge in the treatment of lung adenocarcinoma (LUAD). Existing programmed cell death (PCD) related prognostic models only consider a single mechanism, such as ferroptosis, necroptosis, and pyroptosis, and do not reflect the interaction of multiple mechanisms. This study aims to explore
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Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolitesBeilstein Journal of Organic Chemistry (IF 2.544) Pub Date : 2022-09-07 ,DOI:10.3762/bjoc.18.120Houchao Xu, Anne Wochele, Minghe Luo, Gregor Schnakenburg, Yuhui Sun, Heike Brötz-Oesterhelt, Jeroen S. Dickschat
An improved synthesis for tryptophan-dehydrobutyrine diketopiperazine (TDD), a co-metabolite of the hybrid polyketide/non-ribosomal peptide hangtaimycin, starting from ʟ-tryptophan is presented. Comparison to TDD isolated from the hangtaimycin producer Streptomyces spectabilis confirmed its S configuration. The X-ray structure of the racemate shows an interesting dimerisation through hydrogen bridges
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CYSTEINE-RICH RECEPTOR-LIKE KINASE5 (CRK5) and CRK22 regulate the response to Verticillium dahliae toxins.Plant Physiology (IF 8.005) Pub Date : 2022-08-29 ,DOI:10.1093/plphys/kiac277Jun Zhao,Yuhui Sun,Xinyue Li,Yingzhang LiCysteine-rich receptor-like kinases (CRKs) play critical roles in responses to biotic and abiotic stresses. However, the molecular mechanisms of CRKs in plant defense responses remain unknown. Here, we demonstrated that two CRKs, CRK5 and CRK22, are involved in regulating defense responses to Verticillium dahliae toxins (Vd-toxins) in Arabidopsis (Arabidopsis thaliana). Biochemical and genetic analyses ...
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Soil Erosion Resistance-enlarging Potential by Plant Roots as Determined in a Simulated Flume ExperimentEurasian Soil Science (IF 1.374) Pub Date : 2022-08-23 ,DOI:10.1134/s1064229322100179Zheng Zhang, Qiang Li, Weijie Yu, Hui SunAbstract It has been suggested in previous studies that plant roots enlarged soil resistance to concentrated flow erosion mainly through physical (root net-link and root-soil bonding) and biochemical effects. The objective of this study is to further assess soil resistance-enlarging potential of this twofold effect of roots, especially for different textured soils. Two textured soils (silt loam and ...
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Engineering the surface properties of bamboo scrimber to enhance the gluing propertiesPolymer Composites (IF 3.531) Pub Date : 2022-07-01 ,DOI:10.1002/pc.26852Jiangyuan Wu, Yahui Zhang, Yaohui Ji, Rongxian Zhu, Yuhui Sun, Yanglun Yu, Wenji YuThe adhesive ability of bamboo scrimber is critical for its use in large-scale engineering structures. Cold-pressed bamboo scrimber with varying sanding mesh and density was made and then bonded with polyurethane resin. The adhesive was concentrated on the surface, assisting the anchoring into the material surface. The shear strength and immersion peel strength are studied as parameters to determine ...
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Isothermal and Non-Isothermal Crystallization Kinetics of Poly(Ethylene Chlorotrifluoroethylene)Polymers (IF 4.967) Pub Date : 2022-06-28 ,DOI:10.3390/polym14132630Xiaodong Yang, Bin Yu, Hui Sun, Nan Wang, Peng Liu, Jiangli Feng, Xiaogang Cui
The isothermal (IT) and non-isothermal (NIT) crystallization kinetics, morphology, and structure of poly(ethylene chlorotrifluoroethylene) (ECTFE) were investigated via differential scanning calorimetry (DSC), polarized optical microscopy (POM), and wide-angle X-ray diffraction (XRD). The Avrami equation could well describe the overall IT crystallization process of ECTFE, and, furthermore, the overall
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Utilizing the Transverse Thermoelectric Effect of Thin Films for Pulse Laser DetectionSensors (IF 3.847) Pub Date : 2022-06-28 ,DOI:10.3390/s22134867Yanju Sun, Haorong Wu, Lan Yu, Hui Sun, Peng Zhang, Xiaowei Zhang, Bo Dai, Yong Wang
In this work, pulse laser detectors based on the transverse thermoelectric effect of YBa2Cu3O7-δ thin films on vicinal cut LaAlO3 (001) substrates have been fabricated. The anisotropic Seebeck coefficients between ab-plane (Sab) and c-axis (Sc) of thin films are utilized to generate the output voltage signal in such kind of detectors. Fast response has been determined in these sensors, including both
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Primary pulmonary epithelioid angiosarcoma with thyroid tumor history: A case report and literature review.Experimental and Therapeutic Medicine (IF 2.751) Pub Date : 2022-05-27 ,DOI:10.3892/etm.2022.11398Lu Yu, Yuhui Sun, Meifang Wang, Lingling Yuan, Qiang Wang, Xin Qian
Primary pulmonary epithelioid angiosarcoma is a rare tumor type without any specific clinical and imaging features. Therefore, it is associated with high rates of misdiagnosis. The present study reports the case of a 54-year-old female patient who was admitted after complaining of cough, expectoration and bloody sputum for >5 months in May 2021. The patient reported a previous history of papillary
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Shear Property and Uniform Vertical Load Capacity of Bamboo I-BeamsForests (IF 3.282) Pub Date : 2022-05-25 ,DOI:10.3390/f13060826Xiaomeng Yang, Cong Sun, Faren Huo, Yong Gong, Yuhui Sun
Bamboo oriented strand boards (BOSB) are very suitable for application in construction structures because of their excellent mechanical properties. This research investigated the shear performance of bamboo I-beams composed of BOSB to verify the structural performance of I-beams. Short beam shear tests and uniform vertical load capacity tests were performed to investigate the effects of various factors
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Grafted human ESC-derived astroglia repair spinal cord injury via activation of host anti-inflammatory microglia in the lesion areaTheranostics (IF 11.6) Pub Date : 2022-5-16 ,DOI:10.7150/thno.70929Jian Wang, Peng Jiang, Wenbin Deng, Yuhui Sun, Yaobo Liu
Grafted astroglia/astrocytes exhibit neuroprotective effects and improve functional recovery after injury to the central nervous system. This study sought to elucidate their ability to repair spinal cord lesions and the underlying mechanisms./nMethods: Complete spinal transection, transplantation of astroglia generated from human ESC-derived neural progenitor cells (NPC-Astros) or Olig2-GFP knock-in
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Biological Role of Nodal Modulator: A Comprehensive Review of the Last Two DecadesDNA and Cell Biology (IF 3.55) Pub Date : 2022-04-19 ,DOI:10.1089/dna.2021.0944Yuhui Sun, Tao Li, Xin QianNodal modulator (NOMO) is a type I transmembrane protein that is conserved in various human tissues. Humans have three highly similar NOMO proteins, namely NOMO1, NOMO2, and NOMO3. These three proteins are closely related and may have similar functions. NOMO has been identified as a part of a protein complex that mediates a wide range of biological processes such as tumor formation, bone and cartilage ...
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Mechanism of Microscopic Fracture of Typical Shell Steel under Impact LoadingShock and Vibration (IF 1.616) Pub Date : 2022-02-23 ,DOI:10.1155/2022/1508114Chuan Zhao, Shushan Wang, Cean Guo, Yuhui Sun, Xuncheng Guo, Feng Ma
The aim of the current study was to investigate the effects of strain rate and metallographic structure on the fracture mode and fracture pattern of a typical shell steel material under impact loading. A ballistic gun was used to launch a spherical tungsten alloy projectile to impact target 50SiMnVB and 60Si2Mn steel plates. The morphological characteristics of the cracks on different target plates
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A comprehensive analysis of age-related metabolomics and transcriptomics reveals metabolic alterations in rat bone marrow mesenchymal stem cells.Aging-US (IF 5.955) Pub Date : 2022-01-30 ,DOI:10.18632/aging.203857Xiao Yu,Hui Sun,Xingyu Gao,Chang Zhang,Yanan Sun,Huan Wang,Haiying Zhang,Yingai Shi,Xu He
The functions of stem cells decline progressively with aging, and some metabolic changes occur during the process. However, the molecular mechanisms of stem cell aging remain unclear. In this study, the combined application of metabolomics and transcriptomics technologies can effectively describe the possible molecular mechanisms of rat bone marrow mesenchymal stem cell (BMSC) senescence. Metabolomic
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Sleep disorders and non-sleep circadian disorders predict depression: A systematic review and meta-analysis of longitudinal studiesNeuroscience & Biobehavioral Reviews (IF 9.052) Pub Date : 2022-01-15 ,DOI:10.1016/j.neubiorev.2022.104532Mi-Mi Zhang, Yan Ma, Lan-Ting Du, Ke Wang, Zhe Li, Weili Zhu, Yu-Hui Sun, Lin Lu, Yan-Ping Bao, Su-Xia LiPatients with depression often suffer from sleep disorders and non-sleep circadian disorders. However, whether they precede and predict subsequent depression is unclear. We conducted a meta-analysis of studies on sleep disorders and non-sleep circadian disorders. We found insomnia, hypersomnia, short and long sleep duration, obstructive sleep apnea, restless legs syndrome and eveningness orientation ...
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Moisture-resistant MXene-sodium alginate sponges with sustained superhydrophobicity for monitoring human activitiesChemical Engineering Journal (IF 16.744) Pub Date : 2021-12-28 ,DOI:10.1016/j.cej.2021.134370Yangchengyi Liu, Zhong Sheng, Jielong Huang, Weiyi Liu, Hongyan Ding, Jinfeng Peng, Bowen Zhong, Yuhui Sun, Xiaoping Ouyang, Huanyu Cheng, Xiufeng WangWearable mechanical sensors are susceptible to moisture, causing inaccuracy for monitoring human health and body motions. Although the superhydrophobic barrier on the sensor surface has been extensively explored as a passive water repel strategy, the dense superhydrophobic surface often has limited flexibility and inevitably degradates in high humidity or saturated water vapor environments due to the ...
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Mechanistic Insights into Dideoxygenation in Gentamicin BiosynthesisACS Catalysis (IF 13.7) Pub Date : 2021-09-20 ,DOI:10.1021/acscatal.1c03508Sicong Li, Priscila Dos Santos Bury, Fanglu Huang, Junhong Guo, Guo Sun, Anna Reva, Chuan Huang, Xinyun Jian, Yuan Li, Jiahai Zhou, Zixin Deng, Finian J. Leeper, Peter F. Leadlay, Marcio V. B. Dias, Yuhui Sun
Gentamicin is an important aminoglycoside antibiotic used for treatment of infections caused by Gram-negative bacteria. Although most of the biosynthetic pathways of gentamicin have been elucidated, a remaining intriguing question is how the intermediates JI-20A and JI-20B undergo a dideoxygenation to form gentamicin C complex. Here we show that the dideoxygenation process starts with GenP-catalyzed
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Multitype Damage Detection of Container Using CNN Based on Transfer LearningMathematical Problems in Engineering (IF 1.43) Pub Date : 2021-08-27 ,DOI:10.1155/2021/5395494Zixin Wang, Jing Gao, Qingcheng Zeng, Yuhui Sun
Due to the repeated bearing of mechanical operations and natural factors, the container will suffer various types of damage during use. Adopting effective container damage detection methods plays a vital role in prolonging the service life and using function. This paper proposes a multitype damage detection model for containers based on transfer learning and MobileNetV2. In addition, a data set containing
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The Mechanism of Dehydrating Bimodules in trans-Acyltransferase Polyketide Biosynthesis: A Showcase Study on Hepatoprotective HangtaimycinAngewandte Chemie International Edition (IF 16.823) Pub Date : 2021-07-04 ,DOI:10.1002/anie.202106250Minghe Luo, Houchao Xu, Yulu Dong, Kun Shen, Junlei Lu, Zhiyong Yin, Miaomiao Qi, Guo Sun, Lingjie Tang, Jin Xiang, Zixin Deng, Jeroen S. Dickschat, Yuhui Sun
A bioassay-guided fractionation led to the isolation of hangtaimycin (HTM) from Streptomyces spectabilis CCTCC M2017417 and the discovery of its hepatoprotective properties. Structure elucidation by NMR suggested the need for a structural revision. A putative HTM degradation product was also isolated and its structure was confirmed by total synthesis. The biosynthetic gene cluster was identified and
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