- 作 者: ( "lixia miao" OR "li-xia miao" )
-
Tumor-infiltrating lymphocytes benefit prediction of axillary pathologic response and prognostication of event-free survival in HER2-positive and biopsy-proven node-positive breast cancer treated with neoadjuvant therapy.Breast Cancer Research and Treatment (IF 4.624) Pub Date : 2020-11-09 ,DOI:10.1007/s10549-020-06015-4Shiwei Liu,Shiyan Zeng,Li Xia,Miao Yu,Xin Zhang,Hong Yang,Juan Ji,Hao Dong,Jianhui Zhang,Purong ZhangPURPOSE The present study evaluated tumor-infiltrating lymphocytes (TILs) based on standardized scoring method and investigated its predictive value for axillary pathologic complete response (apCR) and prognostic significance for event-free survival (EFS) in neoadjuvant-treated HER2-positive breast cancer with initially biopsy-proven nodal metastasis. METHODS We assessed TILs in a total of 187 pretherapeutic ...
-
Tumor-infiltrating lymphocytes benefit prediction of axillary pathologic response and prognostication of event-free survival in HER2-positive and biopsy-proven node-positive breast cancer treated with neoadjuvant therapy.Breast Cancer Research and Treatment (IF 4.624) Pub Date : 2020-11-09 ,DOI:10.1007/s10549-020-06015-4Shiwei Liu,Shiyan Zeng,Li Xia,Miao Yu,Xin Zhang,Hong Yang,Juan Ji,Hao Dong,Jianhui Zhang,Purong ZhangPURPOSE The present study evaluated tumor-infiltrating lymphocytes (TILs) based on standardized scoring method and investigated its predictive value for axillary pathologic complete response (apCR) and prognostic significance for event-free survival (EFS) in neoadjuvant-treated HER2-positive breast cancer with initially biopsy-proven nodal metastasis. METHODS We assessed TILs in a total of 187 pretherapeutic ...
-
ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity.Antiviral Research (IF 10.103) Pub Date : 2020-08-26 ,DOI:10.1016/j.antiviral.2020.104922Zhiqiang Xia,Luyao Wang,Songryong Li,Wei Tang,Fang Sun,Yingliang Wu,Lixia Miao,Zhijian CaoArboviruses, especially Dengue virus (DENV) and Zika virus (ZIKV), have been a severe threat to human health in the last few years due to uncontrollable transmission. There are no approved vaccines or clinical drugs available for use to prevent and treat their infections. Transient receptor potential mucolipin 2 and 3 (TRPML2 and TRPML3) were reported to modulate viral entry, but the antiviral function ...
-
Topology, Antiviral Functional Residues and Mechanism of IFITM1.Viruses (IF 5.818) Pub Date : 2020-03-08 ,DOI:10.3390/v12030295Fang Sun,Zhiqiang Xia,Yuewen Han,Minjun Gao,Luyao Wang,Yingliang Wu,Jean-Marc Sabatier,Lixia Miao,Zhijian Cao
Interferon-inducible transmembrane proteins (IFITM1/2/3) have been reported to suppress the entry of a wide range of viruses. However, their antiviral functional residues and specific mechanisms are still unclear. Here, we firstly resolved the topology of IFITM1 on the plasma membrane where N-terminus points into the cytoplasm and C-terminus resides extracellularly. Further, KRRK basic residues of
...
-
ImKTx96, a peptide blocker of the Kv1.2 ion channel from the venom of the scorpion Isometrus maculatesPeptides Pub Date : 2020-01-01 ,DOI:10.1016/j.peptides.2019.170172Sipian Li, Shuwen Sunchen, Dangui He, Chenhu Qin, Zheng Zuo, Bingzheng Shen, Zhijian Cao, Wei Hong, Lixia Miao
Scorpion venom contains diverse bioactive peptides that can recognize and interact with membrane proteins such as ion channels. These natural toxins are believed to be useful tools for exploring the structure and function of ion channels. In this study, we characterized a K+-channel toxin gene, ImKTx96, from the venom gland cDNA library of the scorpion Isometrus maculates. The peptide deduced from
...
-
[Design and application of retention enema device].Zhonghua wei zhong bing ji jiu yi xue Pub Date : 2019-12-01 ,DOI:10.3760/cma.j.issn.2095-4352.2019.12.024Xiaowei Xiang,Zhimin Zhang,Xiang Wang,Lixia Miao,Yuanyuan FuDrug retention enema is a common therapy for various illnesses. However, it is impossible to keep the drug in the colon for a long time, due to the limitation of the current equipment, and it is unable to achieve the purpose of retention enema. A retention enema device was designed by the department of intensive care unit (ICU) of Dongfeng Hospital Affiliated to Hubei University of Medicine. The retention ...
-
ImKTx96, a peptide blocker of the Kv1.2 ion channel from the venom of the scorpion Isometrus maculates.Peptides Pub Date : 2019-10-15 ,DOI:10.1016/j.peptides.2019.170172Sipian Li,Shuwen Sunchen,Dangui He,Chenhu Qin,Zheng Zuo,Bingzheng Shen,Zhijian Cao,Wei Hong,Lixia Miao
Scorpion venom contains diverse bioactive peptides that can recognize and interact with membrane proteins such as ion channels. These natural toxins are believed to be useful tools for exploring the structure and function of ion channels. In this study, we characterized a K+-channel toxin gene, ImKTx96, from the venom gland cDNA library of the scorpion Isometrus maculates. The peptide deduced from
...
-
Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells.Journal of Experimental & Clinical Cancer Research (IF 12.658) Pub Date : 2019-10-10 ,DOI:10.1186/s13046-019-1404-8Fujun Li,Lixia Miao,Teng Xue,Hao Qin,Santanu Mondal,Paul R Thompson,Scott A Coonrod,Xiaoqiu Liu,Xuesen Zhang
BACKGROUND Tamoxifen resistance presents a huge clinical challenge for breast cancer patients. An understanding of the mechanisms of tamoxifen resistance can guide development of efficient therapies to prevent drug resistance. METHODS We first tested whether peptidylarginine deiminase 2 (PAD2) may be involved in tamoxifen-resistance in breast cancer cells. The effect of depleting or inhibiting PAD2
...
-
Peptidylarginine deiminase 4 overexpression resensitizes MCF-7/ADR breast cancer cells to adriamycin via GSK3β/p53 activation.Cancer Management and Research (IF 3.602) Pub Date : 2019-01-10 ,DOI:10.2147/cmar.s191353Qianqian Zhou,Chao Song,Xiaoqiu Liu,Hao Qin,Lixia Miao,Xuesen Zhang
BACKGROUND Adriamycin (ADR) is widely used in the clinical chemotherapy against breast cancer. But its efficacy is strongly limited due to the acquisition of multidrug resistance (MDR). Therefore, acquisition of the resistance to ADR is still a major cause of chemotherapy failure in breast cancer patients. Peptidylarginine deiminase IV (PAD4) is reported to target non-histone proteins for citrullination
...
-
PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling.Cancer Letters (IF 9.756) Pub Date : 2017-08-29 ,DOI:10.1016/j.canlet.2017.08.019Hao Qin,Xiaoqiu Liu,Fujun Li,Lixia Miao,Tingting Li,Boqun Xu,Xiaofei An,Aaron Muth,Paul R Thompson,Scott A Coonrod,Xuesen Zhang
Peptidylargininedeiminase 1 (PAD1) catalyzes protein for citrullination, and this activity has been linked to the epidermal cornification. However, a role for PAD1 in tumorigenesis, including breast cancers has not been previously explored. Here we first showed that PAD1 is overexpressed in human triple negative breast cancer (TNBC). In cultured cells and xenograft mouse models, PAD1 depletion or inhibition
...
-
PSA and Prostate Health Index based prostate cancer screening in a hereditary migration complicated population: implications in precision diagnosis.Journal of Cancer (IF 4.478) Pub Date : 2017-06-14 ,DOI:10.7150/jca.18012Mariyam Akizhanova,Elzira E Iskakova,Valdemir Kim,Xiao Wang,Roman Kogay,Aiym Turebayeva,Qinglei Sun,Ting Zheng,Shenghui Wu,Lixia Miao,Yingqiu Xie
Precision diagnosis requires specific markers for differential ethnic populations. Prostate-Specific Antigen (PSA) level (threshold of 4ng/ml) has been widely used to screen prostate cancer and as reference of pro-biopsy but false diagnosis frequently occurs. Prostate health Index (PHI) is a new diagnosis marker which combines PSA, free PSA and p2PSA4. Overall the PCa screening database is lacking
...
-
Analysis of origin and protein-protein interaction maps suggests distinct oncogenic role of nuclear EGFR during cancer evolution.Journal of Cancer (IF 4.478) Pub Date : 2017-03-12 ,DOI:10.7150/jca.17961Ainur Sharip,Diyora Abdukhakimova,Xiao Wang,Alexey Kim,Yevgeniy Kim,Aigul Sharip,Askarbek Orakov,Lixia Miao,Qinglei Sun,Yue Chen,Zhenbang Chen,Yingqiu Xie
Receptor tyrosine kinase EGFR usually is localized on plasma membrane to induce progression of many cancers including cancers in children (Bodey et al. In Vivo. 2005, 19:931-41), but it contains a nuclear localization signal (NLS) that mediates EGFR nuclear translocation (Lin et al. Nat Cell Biol. 2001, 3:802-8). Here we report that NLS of EGFR has its old evolutionary origin. Protein-protein interaction
...
-
Nuclear matrix metalloproteinases: functions resemble the evolution from the intracellular to the extracellular compartment.Cell Death Discovery (IF 7.109) Pub Date : 2017-01-01 ,DOI:10.1038/cddiscovery.2017.36Yingqiu Xie,Aidana Mustafa,Adina Yerzhan,Dalmira Merzhakupova,Perizat Yerlan,Askarbek N Orakov,Xiao Wang,Yi Huang,Lixia Miao
Matrix metalloproteinase (MMP) is defined as an endopeptidase in the extracellular matrix (ECM), which plays essential roles in physiological processes such as organogenesis, wound healing, angiogenesis, apoptosis and motility. MMPs are produced and assembled in the cytoplasm as proenzymes with a cytoplasmic domain and require extracellular activation. MMPs can degrade receptors, extracellular matrix
...
-
Tumor Promoting Aspects of Senescence in Cancer Progression.Cancer Investigation (IF 2.368) Pub Date : 2016-10-19 ,DOI:10.1080/07357907.2016.1227443Qing Yang,Yingqiu Xie,Lixia MiaoCancers induced by gene mutation, deletion, and genome instability might be related to aging. With similar pathways of aging but distinct functions, senescence at the cellular level is an irreversible arrest of cell cycle. Senescence has long been believed as a barrier to restrict tumor expansion. However, more and more evidence has been shown that senescence inducers regulate epithelial-mesenchymal ...
-
Electromagnetic pulse activated brain microglia via the p38 MAPK pathway.NeuroToxicology (IF 4.398) Pub Date : 2015-12-22 ,DOI:10.1016/j.neuro.2015.12.008Long-Long Yang,Yan Zhou,Wei-Dong Tian,Hai-Juan Li,Kang-Chu-Li,Xia Miao,Guang-Zhou An,Xiao-Wu Wang,Guo-Zhen Guo,Gui-Rong DingPreviously, we found that electromagnetic pulses (EMP) induced an increase in blood brain barrier permeability and the leakage of albumin from blood into brain tissue. Albumin is known to activate microglia cells. Thus, we hypothesised that microglia activation could occur in the brain after EMP exposure. To test this hypothesis, the morphology and secretory function of microglia cells, including the ...
-
High-density lipoprotein-mediated transcellular cholesterol transport in mouse aortic endothelial cells.Biochemical and Biophysical Research Communications (IF 3.322) Pub Date : 2015-08-07 ,DOI:10.1016/j.bbrc.2015.08.011LiXia Miao,Emmanuel U Okoro,ZhiJan Cao,Hong Yang,Evangeline Motley-Johnson,Zhongmao Guo
Accumulation of unesterified cholesterol-rich lipid vesicles in the subendothelial space contributes to atherogenesis. Transport of cholesterol from the subendothelial intima back to the circulating blood inhibits atherosclerosis development; however, the mechanism for this process has not been fully defined. Using cultured mouse aortic endothelial cells (MAECs), we observed that unesterified cholesterol
...
-
Plasma microRNA-320, microRNA-let-7e and microRNA-21 as novel potential biomarkers for the detection of retinoblastomaBiomedical Reports Pub Date : 2014-03-07 ,DOI:10.3892/br.2014.246SHAN-SHAN LIU, YU-SHI WANG, YAN-FENG SUN, LI-XIA MIAO, JUN WANG, YAN-SHAN LI, HONG-YAN LIU, QIU-LING LIU
Retinoblastoma (RB) is a childhood malignancy caused by inactivation of the RB gene, with neuron-specific enolase (NSE) levels considered as its diagnostic marker. MicroRNAs (miRNAs) have been proven to play a significant role in multiple physiological and pathological processes and several miRNAs were identified as tumor biomarkers in recent studies. In the present study, 65 plasma samples were collected
...
-
Plasma microRNA-320, microRNA-let-7e and microRNA-21 as novel potential biomarkers for the detection of retinoblastoma.Biomedical Reports Pub Date : 2014-03-07 ,DOI:10.3892/br.2014.246Shan-Shan Liu,Yu-Shi Wang,Yan-Feng Sun,Li-Xia Miao,Jun Wang,Yan-Shan Li,Hong-Yan Liu,Qiu-Ling Liu
Retinoblastoma (RB) is a childhood malignancy caused by inactivation of the RB gene, with neuron-specific enolase (NSE) levels considered as its diagnostic marker. MicroRNAs (miRNAs) have been proven to play a significant role in multiple physiological and pathological processes and several miRNAs were identified as tumor biomarkers in recent studies. In the present study, 65 plasma samples were collected
...
-
A specific miRNA signature promotes radioresistance of human cervical cancer cells.Cancer Cell International (IF 6.429) Pub Date : 2013-11-29 ,DOI:10.1186/1475-2867-13-118Bin Zhang,Jun Chen,Zhenghua Ren,Yongbin Chen,Jinhui Li,Xia Miao,Yang Song,Tao Zhao,Yurong Li,Yongquan Shi,Dongqing Ren,Junye Liu
BACKGROUND The mechanisms responsible for cervical cancer radioresistance are still largely unexplored. The present study aimed to identify miRNAs associated with radioresistance of cervical cancer cells. METHODS The radioresistant cervical cancer cell variants were established by repeated selection with irradiation. The miRNA profiles of radioresistant cells and their corresponding controls were analyzed
...
-
[Analysis on the safety of ophthalmic artery cannulation for intra-arterial chemotherapy in 42 patients with intraocular stage retinoblastoma].Zhonghua er ke za zhi = Chinese journal of pediatrics Pub Date : 2013-01-11 ,DOI:Qiu-ling Liu,Ya-feng Wang,Geng-sheng Mao,Xin-ji Yang,Yan-feng Sun,Li-xia Miao,Jun Wang,Hai-lian Yuan,Yan-shan Li,Hong-yan Liu,Xiao-ling Wang,Fei ZhaoOBJECTIVE To investigate the safety of treatment with ophthalmic artery cannulation for intra-arterial chemotherapy (IAC) for children with intraocular retinoblastoma (RB). METHOD In the RB Treatment Center of General Hospital of Armed Police Forces between January 2009 and September 2011, 42 patients who were diagnosed intraocular RB and treated with ophthalmic artery cannulation for IAC, 8 patients ...
-
Molecular cloning and characterization of a new cDNA sequence encoding a venom peptide from the centipede Scolopendra subspinipes mutilans.Molekuliarnaia biologiia Pub Date : 2012-11-02 ,DOI:Wanhong Liu,Feng Luo,Jing He,Zhijian Cao,Lixia MiaoMany studies have been performed on venomous peptides derived from animals. However, little of this research has focused on peptides from centipede venoms. Here, a venom gland cDNA library was successfully constructed for the centipede Scolopendra subspinipes mutilans. A new cDNA encoding the precursor of a venom peptide, named SsmTx, was cloned from the venomous gland cDNA library of the centipede ...
-
Molecular cloning and characterization of a new cDNA sequence encoding a venom peptide from the centipede Scolopendra subspinipes mutilansMolecular Biology (IF 1.54) Pub Date : 2012-08-05 ,DOI:10.1134/s0026893312030132Wanhong Liu, Feng Luo, Jing He, Zhijian Cao, Lixia MiaoMany studies have been performed on venomous peptides derived from animals. However, little of this research has focused on peptides from centipede venoms. Here, a venom gland cDNA library was suc-cessfully constructed for the centipede Scolopendra subspinipes mutilans. A new cDNA encoding the precursor of a venom peptide, named SsmTx, was cloned from the venomous gland cDNA library of the centipede ...
-
Hierarchy property of traffic networksChinese Physics B (IF 1.652) Pub Date : 2010-09-01 ,DOI:10.1088/1674-1056/19/9/090510Li Xia-Miao, Zeng Ming-Hua, Zhou Jin, Li Ke-ZanThe flourishing complex network theory has aroused increasing interest in studying the properties of real-world networks. Based on the traffic network of Chang-Zhu-Tan urban agglomeration in central China, some basic network topological characteristics were computed with data collected from local traffic maps, which showed that the traffic networks were small-world networks with strong resilience against ...
-
Cloning and characterization of a new BRCA1 variant: A role for BRCT domains in apoptosis.Cancer Letters (IF 9.756) Pub Date : 2010-04-02 ,DOI:10.1016/j.canlet.2010.03.002Meijia Gu,Hua Li,Chao Shen,Lin Wu,Wanhong Liu,Lixia Miao,Congyi ZhengBRCA1 is a tumor-suppressor gene responsible for hereditary breast and ovarian cancers. Characterization of alternately spliced forms of BRCA1 may identify the region of the gene responsible for its function. Here, we cloned and characterized a new BRCA1 splicing variant from the breast cancer cell line ZR-75-30. This transcript, named BRCA1-E1aA-Delta2-17, lacks most exons found in full-length BRCA1 ...
-
Cloning and functional identification of two novel BRCA1 splicing variants.Biochemistry (Moscow) (IF 2.824) Pub Date : 2009-01-06 ,DOI:10.1134/s0006297908110072Lixia Miao,Zhijian Cao,Chao Shen,Meijia Gu,Wanhong Liu,Hua Li,Congyi ZhengBRCA1 is an important tumor suppressor gene associated with inherited breast and ovarian cancers. In this investigation, two novel BRCA1 splicing variants were cloned from breast cancer cell line ZR-75-30. These transcripts, named BRCA1-PI21-Delta2-21 and BRCA1-Delta2-14, lacked most exons of full length BRCA1 gene, but maintained the original reading frame. We also demonstrated the presence of BRCA1-PI21-Delta2-21 ...
-
Establishment and characterization of three new human breast cancer cell lines derived from Chinese breast cancer tissues.Cancer Cell International (IF 6.429) Pub Date : 2009-01-06 ,DOI:10.1186/1475-2867-9-2Chao Shen,Meijia Gu,Dan Liang,Lixia Miao,Liu Hu,Congyi Zheng,Jiakuan Chen
BACKGROUND Breast cancer is a major malignancy affecting females worldwide. It is the most common cause of death from cancer in women. Cell lines are widely used in laboratory research and particularly as in vitro models in cancer research. But we found that the routinely used breast cancer cell lines were mostly derived from Caucasians or African-Americans. There were few standard models to study
...
-
Cloning and functional identification of two novel BRCA1 splicing variantsBiochemistry (Moscow) (IF 2.824) Pub Date : 2008-11-01 ,DOI:10.1134/s0006297908110072Lixia Miao, Zhijian Cao, Chao Shen, Meijia Gu, Wanhong Liu, Hua Li, Congyi ZhengBRCA1 is an important tumor suppressor gene associated with inherited breast and ovarian cancers. In this investigation, two novel BRCA1 splicing variants were cloned from breast cancer cell line ZR-75-30. These transcripts, named BRCA1-PI21-Δ2-21 and BRCA1-Δ2-14, lacked most exons of full length BRCA1 gene, but maintained the original reading frame. We also demonstrated the presence of BRCA1-PI21-Δ2-21 ...
-
The tumorigenicity diversification in human embryonic kidney 293 cell line cultured in vitro.Biologicals (IF 1.76) Pub Date : 2008-04-02 ,DOI:10.1016/j.biologicals.2008.02.002Chao Shen,Meijia Gu,Ci Song,Lixia Miao,Liu Hu,Dan Liang,Congyi ZhengThe Human Embryonic Kidney (HEK) 293 cell line is widely used in research work such as vaccine production, adenovirus and adeno-associated viral vectors, and gene therapy. However, little attention was drawn to the passage level of 293 cells. We first claim that the tumorigenicity of the HEK 293 cell line reached 100% when the passage exceeded 65, whereas using low-passage (<52) HEK 293 cell line no ...
-
A novel human foamy virus mediated gene transfer of GAD67 reduces neuropathic pain following spinal cord injury.Neuroscience Letters (IF 3.197) Pub Date : 2008-01-09 ,DOI:10.1016/j.neulet.2007.11.054Wanhong Liu,Zhongchun Liu,Li Liu,Zheman Xiao,Xiongbin Cao,Zhijian Cao,Lu Xue,Lixia Miao,Xiaohua He,Wenxin LiNeuropathic pain is a long-lasting clinical problem that is often refractory to medical management. Gene transfer of specific genes for therapeutic benefit offers a novel approach to the treatment of neuropathic pain. In this study, we tested whether the transfer of the glutamic acid decarboxylase (GAD) gene to dorsal root ganglion (DRG) cells would attenuate below-injury level central neuropathic ...
-
[An experimental study on destruction of K562 and HL60 induced by 5-aminolaevulinic acid-based photodynamic therapy].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi Pub Date : 2005-07-15 ,DOI:Baoqin Zhang,Lixia Miao,Zhenxi Zhang,Mi Xiao,Meilan ChenThis experiment was designed to explore the pattern of K562 and HL60 leukemia cells death, the effects on their cell cycle and the cytoplasmic free calcium concentration ([Ca2+]i) induced by 5-aminolaevulinic acid-based photodynamic therapy (ALA-PDT). Under the transmission electron microscope (TEM), two kinds of leukemia cells' ultrastructure were observed. Flow cytometry combined with Annexin V-FITC/PI ...
广告：喜“文”乐“荐”|邀请好友使用Taylor & Francis Editing Services编辑润色服务，共享专属优惠！推荐人数无限制！
高级搜索
我的搜索条件
京公网安备 11010802027423号