- 作 者: "xin lu"
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Information Security Architecture Design for Cyber-Physical Integration System of Air Traffic ManagementElectronics (IF 2.69) Pub Date : 2023-03-31 ,DOI:10.3390/electronics12071665Xin Lu, Ruochen Dong, Qing Wang, Lizhe ZhangWith the continuous expansion of air traffic flow, the increasingly serious aviation network security threats have a significant and far-reaching impact on the safe operation of the aviation industry. The networked air traffic management (ATM) system is an integrated space–air–ground network integrating communication, network, satellite, and data chain technology, which adopts a network-centric structure ...
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Construction of Axially Chiral Arylpyrroles via Atroposelective Diyne CyclizationAngewandte Chemie International Edition (IF 16.823) Pub Date : 2023-03-30 ,DOI:10.1002/anie.202303670Yang-Bo Chen, Li-Gao Liu, Can-Ming Chen, Yi-Xi Liu, Bo Zhou, Xin Lu, Zhou Xu, Long-Wu YeAxially chiral biaryls widely exist in natural products and pharmaceuticals and are used as chiral ligands and catalysts in asymmetric synthesis. Compared to the well-established axially chiral 6-membered biaryl skeletons, examples of 5-membered biaryls have been quite scarce, and mono-substituted 3-arylpyrrole atropisomers have not been reported. Here, we disclose a copper-catalyzed atroposelective ...
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A review of filamentous sludge bulking controls from conventional methods to emerging quorum quenching strategiesWater Research (IF 13.4) Pub Date : 2023-03-29 ,DOI:10.1016/j.watres.2023.119922Xin Lu, Ge Yan, Liang Fu, Bin Cui, Jinfeng Wang, Dandan ZhouFilamentous bulking, which results from the overgrowth of filamentous microorganisms, is a common issue that frequently disrupts the stable operation of activated sludge processes. Recent literature has paid attention to the relationship between quorum sensing (QS) and filamentous bulking highlighting that the morphological transformations of filamentous microbes are regulated by functional signal ...
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Modulation of long noncoding RNA (lncRNA) and messenger RNA (mRNA) expression in the liver of Beagle dogs by Toxocara canis infectionParasites & Vectors (IF 4.047) Pub Date : 2023-03-29 ,DOI:10.1186/s13071-023-05738-9Yang Zou, Wen-Bin Zheng, Hany M. Elsheikha, Jun-Jun He, Yi-Xin Lu, Shuai Wang, Aijiang Guo, Xing-Quan Zhu
Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play crucial roles in regulating various physiological and pathological processes. However, the role of lncRNAs and mRNAs in mediating the liver response during Toxocara canis infection remains incompletely understood. In the present study, the expression profile of lncRNAs and mRNAs was investigated in the liver of Beagle dogs infected by T
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Experimental and numerical study on the critical initiation radii of 1,3-Butadiene/Oxygen/Helium flame under elevated pressuresFuel (IF 8.035) Pub Date : 2023-03-28 ,DOI:10.1016/j.fuel.2023.128191Xin Lu, Erjiang Hu, Sage Kokjohn, Arun Ravindran, Zheng Chen, Ke Zeng, Zuohua HuangA numerical and experimental study investigated the first and second critical initiation radii of 1,3-butadiene/oxygen/helium flame initiation. A minimum critical flame radius was measured and compared with a calculated first critical initiation radius since the first radius is hard to obtain experimentally. Experiments were conducted in a constant-pressure combustion chamber under pressure up to 1 ...
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Recycling of steel slag powder in green ultra-high strength concrete (UHSC) mortar at various curing conditionsJournal of Building Engineering (IF 7.144) Pub Date : 2023-03-28 ,DOI:10.1016/j.jobe.2023.106361Dingqiang Fan, Chunpeng Zhang, Jian-Xin Lu, Kangning Liu, Tianyi Yin, Enlai Dong, Rui YuThe large quantity of steel slag deposit has caused great environmental pressure. This study aims to recycle steel slag as binder in the production of green ultra-high strength concrete (UHSC) subjected to different curing regimes (i.e. standard and steam curing). The fresh behaviors, mechanical properties, microstructure and ecological value of the UHSC are explicitly assessed with the help of the ...
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Disentangling Phase and Morphological Evolution During the Formation of the Lithium Superionic Conductor Li10GeP2S12Small (IF 15.153) Pub Date : 2023-03-28 ,DOI:10.1002/smll.202300850Xin Lu, Anna Windmüller, Dana Schmidt, Sandro Schöner, Roland Schierholz, Chih-Long Tsai, Hans Kungl, Xunfan Liao, Shicheng Yu, Hermann Tempel, Yiwang Chen, Rüdiger-A. EichelThe structural and morphological changes of the Lithium superionic conductor Li10GeP2S12, prepared via a widely used ball milling-heating method over a comprehensive heat treatment range (50 – 700 °C), are investigated. Based on the phase composition, the formation process can be distinctly separated into four zones: Educt, Intermediary, Formation, and Decomposition zone. It is found that instead of ...
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Clinical response to adding pyrotinib to pembrolizumab and lenvatinib for HER2-positive advanced intrahepatic cholangiocarcinoma: a case reportWorld Journal of Surgical Oncology (IF 3.253) Pub Date : 2023-03-27 ,DOI:10.1186/s12957-023-02983-1Jun-Wei Zhang, Xiaobo Yang, Boju Pan, Yiyao Xu, Xin Lu, Hai-tao Zhao
Intrahepatic cholangiocarcinoma (ICC) is a highly lethal hepatobiliary cancer, and very few patients can undergo surgery. The prognosis of advanced ICC is poor, especially in patients who progress after first-line chemotherapy, with a median overall survival of less than 10 months. A 64-year-old male was diagnosed with advanced intrahepatic cholangiocarcinoma with ERBB2 (HER2) 3 + amplification determined
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Sexually dimorphic age-related molecular differences in the entorhinal cortex of cognitively intact elderly: Relation to early Alzheimer's changesAlzheimer's & Dementia (IF 16.655) Pub Date : 2023-03-24 ,DOI:10.1002/alz.13037Xin-Lu Chen, Jennifer Monteiro Fortes, Yu-Ting Hu, Juliet van Iersel, Kang-Ning He, Joop van Heerikhuize, Rawien Balesar, Dick Swaab, Ai-Min BaoWomen are more vulnerable to Alzheimer's disease (AD) than men. The entorhinal cortex (EC) is one of the earliest structures affected in AD. We identified in cognitively intact elderly different molecular changes in the EC in relation to age. ...
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Sign structure in the square-lattice $t$-$t^\prime$-$J$ model and numerical consequencesarXiv - PHYS - Superconductivity Pub Date : 2023-03-23 ,DOI:arxiv-2303.13498Xin Lu, Jia-Xin Zhang, Shou-Shu Gong, D. N. Sheng, Zheng-Yu WengUnderstanding the doped Mott insulator is a central challenge in condensed matter physics. This study identifies an intrinsic Berry-phase-like sign structure for the square-lattice $t$-$t'$-$J$ model with the nearest-neighbor ($t$) and next-nearest-neighbor hopping ($t'$), which could help explain the origin of the quasi-long-range superconducting and stripe phases observed through density matrix renormalization ...
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Sign structure in the square-lattice $t$-$t^\prime$-$J$ model and numerical consequencesarXiv - PHYS - Strongly Correlated Electrons Pub Date : 2023-03-23 ,DOI:arxiv-2303.13498Xin Lu, Jia-Xin Zhang, Shou-Shu Gong, D. N. Sheng, Zheng-Yu WengUnderstanding the doped Mott insulator is a central challenge in condensed matter physics. This study identifies an intrinsic Berry-phase-like sign structure for the square-lattice $t$-$t'$-$J$ model with the nearest-neighbor ($t$) and next-nearest-neighbor hopping ($t'$), which could help explain the origin of the quasi-long-range superconducting and stripe phases observed through density matrix renormalization ...
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Day-ahead electricity price forecasting employing a novel hybrid frame of deep learning methods: A case study in NSW, AustraliaElectric Power Systems Research (IF 3.818) Pub Date : 2023-03-22 ,DOI:10.1016/j.epsr.2023.109300Yong Qiang Tan, Yan Xia Shen, Xin Yan Yu, Xin LuDay-ahead electricity price forecasting plays a vital role in electricity markets under liberalization and deregulation, which can provide references for participants in bidding strategies, energy trading, and risk management. However, due to various uncertain factors, electricity prices often exhibit nonlinearity, randomness, and volatility, adding technical difficulties to accurate price forecasting ...
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A Strategy for Uncovering the Serum Metabolome by Direct-Infusion High-Resolution Mass SpectrometryMetabolites (IF 5.581) Pub Date : 2023-03-22 ,DOI:10.3390/metabo13030460Xiaoshan Sun, Zhen Jia, Yuqing Zhang, Xinjie Zhao, Chunxia Zhao, Xin Lu, Guowang Xu
Direct infusion nanoelectrospray high-resolution mass spectrometry (DI-nESI-HRMS) is a promising tool for high-throughput metabolomics analysis. However, metabolite assignment is limited by the inadequate mass accuracy and chemical space of the metabolome database. Here, a serum metabolome characterization method was proposed to make full use of the potential of DI-nESI-HRMS. Different from the widely
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Regulation of beta-amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compoundsMedicinal Research Reviews (IF 12.388) Pub Date : 2023-03-21 ,DOI:10.1002/med.21947Weimin Qiu, Hui Liu, Yijun Liu, Xin Lu, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng SunAlzheimer's disease (AD) is a progressive neurodegenerative disease that is difficult to treat. Extracellular amyloid is the principal pathological criterion for the diagnosis of AD. Amyloid β (Aβ) interacts with various receptor molecules on the plasma membrane and mediates a series of signaling pathways that play a vital role in the occurrence and development of AD. Research on receptors that interact ...
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C-reactive Protein/Albumin Ratio as a Prognostic Indicator in Posttraumatic Shock and Outcome of Multiple Trauma PatientsCurrent Medical Science (IF 1.273) Pub Date : 2023-03-21 ,DOI:10.1007/s11596-023-2714-9Xin Lu, Wei-chen Liu, Yan Qin, Du Chen, Peng Yang, Xiong-hui Chen, Si-rong Wu, Feng XuObjective C-reactive protein (CRP)/albumin ratio (CAR) is a new inflammation-based index for predicting the prognosis of various diseases. The CAR determined on admission may help to predict the prognostic value of multiple trauma patients. Methods A total of 264 adult patients with severe multiple trauma were included for the present retrospective study, together with the collection of relevant clinical ...
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Mussel-Inspired Caries Management Strategy: Constructing a Tribioactive Tooth Surface with Remineralization, Antibiofilm, and Anti-inflammation ActivityACS Applied Materials & Interfaces (IF 10.383) Pub Date : 2023-03-20 ,DOI:10.1021/acsami.2c21672Yu Xu, Jiawei Guan, Qi Wang, Rui Xue, Zhirong He, Xin Lu, Jingmin Fan, Hang Yu, Chimengul Turghun, Wei Yu, Zhijian Li, Sirapil Abay, Wen Chen, Bo HanDental caries is a common chronic oral disease in humans resulting from tooth demineralization caused by acid production of bacterial plaque, which leads to the destruction of enamel and dentin and oral inflammation. However, it is still a challenge that the function of natural active ingredients in currently available oral care products is not comprehensive, especially the lack of remineralization ...
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Efficient utilization of waste CRT glass in low carbon super-sulfated cement mortarCement & Concrete Composites (IF 9.93) Pub Date : 2023-03-18 ,DOI:10.1016/j.cemconcomp.2023.105037Jiaxing Ban, Jian-Xin Lu, Ligang Peng, Hongjian Du, Jun Yao, Chi Sun PoonThis study developed a novel low carbon super-sulfated cement (SSC) mortar prepared with multiple types of solid wastes, including phosphogypsum and cathode ray tube (CRT) panel glass. The properties of this cement mortar were compared with the OPC/river sand counterpart with respect to durability and environmental performance. The pozzolanic reaction between the active surface of the CRT glass and ...
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Efficient utilization of waste CRT glass in low carbon super-sulfated cement mortarCement and Concrete Composites Pub Date : 2023-03-18 ,DOI:10.1016/j.cemconcomp.2023.105037Jiaxing Ban, Jian-Xin Lu, Ligang Peng, Hongjian Du, Jun Yao, Chi Sun PoonThis study developed a novel low carbon super-sulfated cement (SSC) mortar prepared with multiple types of solid wastes, including phosphogypsum and cathode ray tube (CRT) panel glass. The properties of this cement mortar were compared with the OPC/river sand counterpart with respect to durability and environmental performance. The pozzolanic reaction between the active surface of the CRT glass and ...
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Phase-field study of the effect of stress field and fission rate on intragranular Xe bubble evolution in U3Si2 nuclear fuelFrontiers in Energy Research (IF 3.858) Pub Date : 2023-03-17 ,DOI:10.3389/fenrg.2023.1092433Cong Ma, Caiyan Liu, Min Zhao, Tianyuan Xin, Lu Wu, Rongjian Pan, Jiantao Qin, Jing Zhang
Due to the superior thermal conductivity and high uranium density, U3Si2 is an excellent candidate for conventional UO2 nuclear fuel and shows great potential application in accident-tolerant fuel (ATF) assembly of light water reactors (LWRs). Currently, the behavior of Xe bubbles with internal or applied stress is rarely investigated, restricting further understanding of swelling in U3Si2. The mesoscopic
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Single-Molecular Poly(propylene oxide) (PPO) Nucleus-Guided Assembly for Hydrophobicity-Dependent Molecular Transport in the NanoporeLangmuir (IF 4.331) Pub Date : 2023-03-16 ,DOI:10.1021/acs.langmuir.3c00447Jianhan Ye, Juanjuan Zheng, Xin Lu, Fen Wu, Nannan Liu, Yuanchen Dong, Qian Shi, Lijin Xu, Dongsheng LiuBy combining DNA nanotechnology and solid-phase nanopore technology, the aggregation behavior of polymer guided by a single-molecular poly(propylene) (PPO) nucleus in a 3D DNA network has been studied. At low temperature, the PPO chain is evenly dispersed in the rigid 3D DNA network; at higher temperature, the PPO chain self-collapses to a single-molecular nucleus; and upon addition of amphiphilic ...
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NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation.Protein & Cell (IF 15.328) Pub Date : 2023-03-16 ,DOI:10.1093/procel/pwac017Yirui Cheng,Xin Lu,Fan Li,Zhuo Chen,Yanshuang Zhang,Qing Han,Qingyu Zeng,Tingyu Wu,Ziming Li,Shun Lu,Cecilia Williams,Weiliang Xia
NDFIP1 has been previously reported as a tumor suppressor in multiple solid tumors, but the function of NDFIP1 in NSCLC and the underlying mechanism are still unknown. Besides, the WW domain containing proteins can be recognized by NDFIP1, resulted in the loading of the target proteins into exosomes. However, whether WW domain-containing transcription regulator 1 (WWTR1, also known as TAZ) can be packaged
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A key driver to promote HCC: Cellular crosstalk in tumor microenvironmentFrontiers in Oncology (IF 5.738) Pub Date : 2023-03-15 ,DOI:10.3389/fonc.2023.1135122Pengyue Liu, Lingyu Kong, Ying Liu, Gang Li, Jianjia Xie, Xin Lu
Liver cancer is the third greatest cause of cancer-related mortality, which of the major pathological type is hepatocellular carcinoma (HCC) accounting for more than 90%. HCC is characterized by high mortality and is predisposed to metastasis and relapse, leading to a low five-year survival rate and poor clinical prognosis. Numerous crosstalk among tumor parenchymal cells, anti-tumor cells, stroma
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Modeling Methodology for Site Selection Evaluation of Underground Coal Gasification Based on Combination Weighting Method with Game TheoryACS Omega (IF 4.132) Pub Date : 2023-03-14 ,DOI:10.1021/acsomega.3c00626Wen-gang Huang, Shao-wei Zhang, Guo-zhi Wang, Jun Huang, Xin Lu, Shu-liang Wu, Zuo-tang Wang
The lack of systematic geological work is an essential reason why underground coal gasification (UCG) has not been industrialized for a long time. Building a scientific index system and favorable area evaluation technology for the UCG site selection is the key to breaking through the geological bottleneck. Aiming at the problems of the single index weight determination method, intense subjectivity
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Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damageNeuron (IF 18.688) Pub Date : 2023-03-14 ,DOI:10.1016/j.neuron.2023.02.022Han-Wei Liu, Li-Na Gong, Ke Lai, Xia-Fei Yu, Zhen-Qi Liu, Ming-Xian Li, Xin-Lu Yin, Min Liang, Hao-Song Shi, Lin-Hua Jiang, Wei Yang, Hai-Bo Shi, Lu-Yang Wang, Shan-Kai Yin
Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how bilirubin worsens outcomes remains mysterious. We report that post-, but not pre-, stroke bilirubin levels among inpatients scale with infarct volume. In mouse models, bilirubin increases neuronal excitability and ischemic infarct, whereas ischemic insults induce the release of endogenous bilirubin, all of which
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HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5bioRxiv - Cancer Biology Pub Date : 2023-03-13 ,DOI:10.1101/2022.05.12.491688Curteisha Jacobs, Sakhi Shah, Wen-Cheng Lu, Haimanti Ray, John Wang, George Sandusky, Kenneth Nephew, Xin Lu, Sha Cao, Richard L Carpenter
Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes cancer cell malignancy. A novel HSF1 Activity Signature (HAS) was found to be negatively associated with antitumor immune cells in breast tumors. Knockdown of HSF1 decreased tumor size and caused an influx of several antitumor immune cells, most notably CD8+ T cells. Depletion of CD8+ T cells prevented tumors from
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HSF1 excludes CD8+ T cells from breast tumors via suppression of CCL5bioRxiv - Bioinformatics Pub Date : 2023-03-13 ,DOI:10.1101/2022.05.12.491688Curteisha Jacobs, Sakhi Shah, Wen-Cheng Lu, Haimanti Ray, John Wang, George Sandusky, Kenneth Nephew, Xin Lu, Sha Cao, Richard L Carpenter
Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes cancer cell malignancy. A novel HSF1 Activity Signature (HAS) was found to be negatively associated with antitumor immune cells in breast tumors. Knockdown of HSF1 decreased tumor size and caused an influx of several antitumor immune cells, most notably CD8+ T cells. Depletion of CD8+ T cells prevented tumors from
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Multimorbidity of Allergic Conditions in Urban Citizens of Southern China: A Real-World Cross-Sectional StudyJournal of Clinical Medicine (IF 4.964) Pub Date : 2023-03-13 ,DOI:10.3390/jcm12062226Ya-Ting Li, Ming-Hui Hou, Ya-Xin Lu, Pei-Ran Chen, Zhen-Yuan Dai, Li-Fen Yang, Ping-Ping Zhang, Guo-Wei Xiong, Zi-Feng Liu, Qi-Lin Zhou, Jing Su, Yun Cheng, Yu-Qi Zhou, Jin Tao, Xue-Kun Huang, Min Dai, Kun Zhang, Min Zhou, Qin-Tai Yang, Pei-Ying Feng, Zhuang-Gui Chen
Background: Extensive knowledge of allergic multimorbidities is required to improve the management of allergic diseases with the industrialization of China. However, the demography and allergen distribution patterns of allergic multimorbidities in China remain unclear, despite the increasing prevalence of allergies. Methods: This was a real-world, cross-sectional study of 1273 outpatients diagnosed
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Safety and Perioperative Outcomes of Laparoscopic vs. Open Hepatectomy of Central-Located Liver Lesions: A Multicenter, Propensity Score-Matched, Retrospective Cohort Study.Journal of Clinical Medicine (IF 4.964) Pub Date : 2023-03-10 ,DOI:10.3390/jcm12062164Bao Jin,Muyi Yang,Yinhan Wang,Gang Xu,Yuxin Wang,Yuke Zhang,Yitong Liu,Xinming Niu,Xiao Liu,Xueshuai Wan,Huayu Yang,Xin Lu,Xinting Sang,Yilei Mao,Zhixian Hong,Shunda Du
BACKGROUND Short-term outcomes of laparoscopic hepatectomy of central-located liver lesions (LHCL) compared with traditional open hepatectomy of central-located liver lesions (OHCL) remain unclear. The aim of this study was to explore the safety and efficacy of LHCL. METHODS A retrospective analysis was performed on 262 patients who underwent hepatectomies involving resections of liver segment II,
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Targeting the chromatin effector Pygo2 promotes cytotoxic T cell responses and overcomes immunotherapy resistance in prostate cancerScience Immunology (IF 30.63) Pub Date : 2023-03-10 ,DOI:10.1126/sciimmunol.ade4656Al Janabi, Gang Huang, Jackson Mittlesteadt, Michael Cheng, Atul Bhardwaj, Brandon L. Ashfeld, Kenneth R. Kao, Dean Y. Maeda, Xing Dai, Olaf Wiest, Brian S.J. Blagg, Xuemin Lu, Liang Cheng, Jun Wan, Xin LuThe noninflamed microenvironment in prostate cancer represents a barrier to immunotherapy. Genetic alterations underlying cancer cell–intrinsic oncogenic signaling are increasingly appreciated for their role in shaping the immune landscape. Recently, we identified Pygopus 2 ( PYGO2 ) as the driver oncogene for the amplicon at 1q21.3 in prostate cancer. Here, using transgenic mouse models of metastatic ...
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Prognosis of Primary Liver Cancer Based on LI-RADS Classification with Extracellular Agent-Enhanced MRIJournal of Hepatocellular Carcinoma (IF 4.962) Pub Date : 2023-03-09 ,DOI:10.2147/jhc.s394840Yubo Li, Xiaoyan Ni, Xinai Liu, Chun Yang, Yi Wang, Xin Lu, Changwu Zhou
Objective: The prognostic value of the Liver Imaging Reporting and Data System (LI-RADS) 2018 in differentiating hepatocellular carcinoma (HCC) from other primary liver cancers (PLC) with cirrhosis is unclear. We aim to evaluate the value of LI-RADS 2018 with agent-enhanced MRI in the postoperative prognosis of PLC patients with cirrhosis. Methods: Between 2016 and 2021, 432 patients with cirrhosis
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