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Implementation frameworks guiding digital self‐management intervention in chronic pain: A scoping review Eur. J. Pain (IF 3.6) Pub Date : 2024-03-14 R. de la Vega, S. L. Bartels, R. W. Wicksell
Background and ObjectiveThe development, evaluation and implementation of digital self‐management interventions for chronic pain have increased exponentially. While intervention outcomes appear promising to improve well‐being and functioning in target populations, it is unclear how the development and evaluation processes were structured and how implementation was planned and executed. The aim of this
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A SUNCT‐like headache associated with lateral pontine infarction – case series and systematic review Eur. J. Pain (IF 3.6) Pub Date : 2024-03-13 Priabprat Jansem, Nattapat Watanapa, Sekh Thanprasertsuk, Wanakorn Rattanawong, Thanakit Pongpitakmetha, Prakit Anukoolwittaya
Background and AimShort‐lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) and autonomic symptoms (SUNA) are trigeminal autonomic cephalalgias (TACs). The study explores the potential association between SUNCT/SUNA‐like headaches and lateral pontine infarctions.MethodsCase series and systematic review.ResultsWe present three cases diagnosed with SUNCT following
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Commentary to ‘Movement‐evoked pain is not associated with pain at rest or physical function in knee osteoarthritis’ Eur. J. Pain (IF 3.6) Pub Date : 2024-03-11 Alisa J. Johnson, Staja Q. Booker, Katie A. Butera, Ruth L. Chimenti, Ericka N. Merriwether, Patrick J. Knox, Arthur Woznowski‐Vu, Corey B. Simon
Movement-evoked pain (MEP), or pain that occurs with or is provoked by movement, is prevalent in individuals with knee osteoarthritis (KOA) and is associated with mobility impairment, clinical pain and poor health outcomes (Butera et al., 2024). Recent studies and literature reviews show that MEP is distinguishable from pain-at-rest (PAR) and is driven by shared and distinct mechanisms, underscoring
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Is Pilates more effective than aerobic exercise in the treatment of fibromyalgia? Discussing a clinical trial Eur. J. Pain (IF 3.6) Pub Date : 2024-03-09 André Pontes‐Silva
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Objectively measured activity is not associated with average pain intensity 1 week after surgery: A cross‐sectional study Eur. J. Pain (IF 3.6) Pub Date : 2024-03-07 M. Komann, J. Dreiling, P. Baumbach, C. Weinmann, E. Kalso, U. Stamer, T. Volk, E. Pogatzki‐Zahn, H. Kehlet, W. Meissner
BackgroundMeasures of physical activity and pain‐related patient‐reported outcomes are important components of patient recovery after surgery. However, little is known about their association in the early post‐operative period. This study aims to increase this knowledge. Our primary objective was to determine the association between average pain intensity and activity (in steps) 1 week after surgery
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Veterans with chronic pain: Examining gender differences in pain type, overlap, and the impact of post‐traumatic stress disorder Eur. J. Pain (IF 3.6) Pub Date : 2024-03-07 Katherine Hadlandsmyth, Mary A. Driscoll, Nicole L. Johnson, Jasmine G. Mares, Michelle A. Mengeling, Emily B. K. Thomas, Sonya B. Norman, Brian C. Lund
BackgroundWomen are more likely to experience multiple overlapping pain conditions (MOPCs) relative to men. Post‐traumatic stress disorder can negatively impact the severity and trajectory of chronic pain and its treatment. Specific associations between gender, post‐traumatic stress disorder (PTSD), and MOPCs require further examination.MethodsA cohort of all Veterans in 2021 who met criteria for one
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Investigation of directional discrimination in the nociceptive system using temperature‐controlled laser stimuli Eur. J. Pain (IF 3.6) Pub Date : 2024-03-05 Ahmad Rujoie, Ole Kæseler Andersen, Ken Steffen Frahm
BackgroundCutaneous laser stimulation has commonly been employed to investigate the thermal properties of the nociceptive system. The aim of this study was to investigate how a temperature‐controlled laser system improves the assessment of directional discrimination in the nociceptive system.MethodsIn total, twenty healthy volunteers participated in this study. To determine the directional discrimination
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Continuum of somatosensory profiles in breast cancer survivors with and without pain, compared to healthy controls and patients with fibromyalgia Eur. J. Pain (IF 3.6) Pub Date : 2024-03-05 Vincent Haenen, Lore Dams, Mira Meeus, Nele Devoogdt, Bart Morlion, Amber De Groote, An De Groef
ContextThe prevalence of persistent pain among breast cancer survivors (BCS) is high, and it is unclear what distinguishes those with persistent pain from those without. Research suggests that differences in somatosensory function evaluated by quantitative sensory testing (QST) may be responsible.ObjectivesThis study aimed to describe somatosensory profiles in terms of hyper‐ and hypoesthesia in BCS
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Guided internet‐based acceptance and commitment therapy for provoked vestibulodynia: A randomized controlled trial Eur. J. Pain (IF 3.6) Pub Date : 2024-03-02 Monica Buhrman, Hanna Hällström, Annika Fridén, Emma Kettis Moden, Gunnar Grahn, Maja Carlfjord, Camille Hjo, Nils Gasslander, Nina Bohm‐Starke, Lance M. McCracken
BackgroundProvoked vestibulodynia (PVD) causes suffering in many women's lives due to its impact on relationships, sexual functioning and functioning in other key domains.ObjectiveHere, we report a randomized controlled trial conducted to examine whether Acceptance and Commitment Therapy (ACT) with a focus on values‐based exposure, delivered online, benefits women with PVD.MethodsParticipants (n =
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A potential link between inflammatory profiles, clinical pain, pain catastrophizing and long‐term outcomes after total knee arthroplasty surgery Eur. J. Pain (IF 3.6) Pub Date : 2024-02-26 Rocco Giordano, Camilla Capriotti, Maria Carla Gerra, Andreas Kappel, Svend Erik Østgaard, Cristina Dallabona, Lars Arendt‐Nielsen, Kristian Kjær‐Staal Petersen
BackgroundChronic postoperative pain after total knee replacement (TKR) is a major clinical problem. It is still unclear if specific inflammatory mediators are associated with long‐term postoperative pain complications. The current exploratory study aimed to (1) evaluate a multiplex of inflammatory mediators 5 years after TKR surgery in patients with different degrees of postoperative pain intensities
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Response to “Comment on ‘The importance of context (placebo effects) in conservative interventions for musculoskeletal pain: A systematic review and meta‐analysis of randomized controlled trials’ by Saueressig et al.” Eur. J. Pain (IF 3.6) Pub Date : 2024-02-24 Tobias Saueressig, Patrick J. Owen, Hugo Pedder, Scott Tagliaferri, Svenja Kaczorowski, Clint T. Miller, Lars Donath, Daniel L. Belavy
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Is pain ever acceptable? A qualitative exploration concerning adult perceptions of chronic pain Eur. J. Pain (IF 3.6) Pub Date : 2024-02-24 Hanaa Kahtan, Abbie Jordan, Patrice Forget
BackgroundAlthough the challenges of living with chronic pain are widely documented within existing literature, to our knowledge, the acceptability of pain for people living with persistent pain, has not been fully explored. The current study aims to explore what ‘acceptable pain’ means to adults living with chronic non‐cancer pain (CPCP).MethodsA total of 117 participants (aged 21 to 77 years) worldwide
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Non‐invasive non‐pharmacological therapies for chronic pain: A commentary on Ikarashi et al. Eur. J. Pain (IF 3.6) Pub Date : 2024-02-24 Nabi Rustamov, Simon Haroutounian, Eric C. Leuthardt
This journal recently published a paper by Ikarashi et al. entitled ‘Modulation of pain perception through transcranial alternating current stimulation and its nonlinear relationship with the simulated electric field magnitude’ (Ikarashi et al., 2024). The study demonstrated that theta- and beta-transcranial alternating current stimulation (tACS) applied to the left dorsolateral prefrontal cortex (DLPFC)
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Systematic review and co‐ordinate based meta‐analysis to summarize the utilization of functional brain imaging in conjunction with human models of peripheral and central sensitization Eur. J. Pain (IF 3.6) Pub Date : 2024-02-21 Sophie Clarke, Richard Rogers, Vishvarani Wanigasekera, Francesca Fardo, Hossein Pia, Zahra Nochi, Nicolas Macian, Vincent Leray, Nanna Brix Finnerup, Gisèle Pickering, André Mouraux, Andrea Truini, Rolf‐Detlef Treede, Luis Garcia‐Larrea, Irene Tracey
Background and ObjectiveFunctional magnetic resonance imaging, in conjunction with models of peripheral and/or central sensitization, has been used to assess analgesic efficacy in healthy humans. This review aims to summarize the use of these techniques to characterize brain mechanisms of hyperalgesia/allodynia and to evaluate the efficacy of analgesics.Databases and Data TreatmentSearches were performed
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Associations of long‐term clinical recovery and improved quality of life across ICD‐11 chronic pain categories in a real‐world registry study Eur. J. Pain (IF 3.6) Pub Date : 2024-02-19 Nadine Farnes, Lars‐Petter Granan, Henrik B. Jacobsen, Audun Stubhaug, Sara M. Vambheim
BackgroundThere is little knowledge of what factors are needed for successful chronic pain management. We aim to identify psychosocial and treatment predictors of clinical recovery and improved quality of life (QOL) at 12‐month follow‐up across three chronic pain groups, based on the International Classification of Diseases‐11: neuropathic pain, secondary non‐neuropathic pain, and primary pain. Furthermore
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Exercise combined with Acceptance and Commitment Therapy for chronic pain: One-year follow-up from a randomized controlled trial Eur. J. Pain (IF 3.6) Pub Date : 2024-02-13 M. B. Casey, S. Takemasa, T. O'Reilly, M. Leamy, E. Mc Kearney, M. Buckley, K. M. Smart, R. Segurado, D. Lowry, D. Flanagan, H. Gopal, C. Hearty, C. Doody
Acceptance and Commitment Therapy (ACT) is a type of Cognitive Behavioural Therapy, which has demonstrated positive outcomes in individuals with chronic pain. The purpose of this study was to compare the effect of an 8-week programme combining Exercise with Acceptance and Commitment Therapy (ExACT) with a standalone supervised exercise programme at 1-year follow-up.
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A matter of personality and point of view: How the interplay of reinforcement sensitivity and general attitudes towards pain impacts the responsivity to acute pain Eur. J. Pain (IF 3.6) Pub Date : 2024-02-08 A. Vetterlein, S. A. Hogeterp, M. Monzel, M. Reuter
The relatively stable individual differences reflected in Grey's revised reinforcement sensitivity theory (rRST), with foundations in neurophysiology and learning theory, appear particularly applicable to the study of pain. However, remarkably little research has been conducted in this area. In acute pain, activation of the behavioural approach system (BAS), the behavioural inhibition system (BIS)
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In search of a neuropsychological profile for migraine: A scoping review Eur. J. Pain (IF 3.6) Pub Date : 2024-02-06 Shannon Richardson, Unai Diaz-Orueta
Migraine is commonly overlooked by the general population and by professionals in research and clinical practice. Moreover, it is difficult to grasp the neuropsychological profile of migraineurs due to the cyclic nature of the disorder. With this in mind, a scoping review of the literature was conducted with the goal of characterizing cognitive domains associated with deficits in migraine.
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Multidisciplinary management of persistent pain in primary care—A systematic review Eur. J. Pain (IF 3.6) Pub Date : 2024-01-31 Merja H. Huttunen, Markus Paananen, Jouko Miettunen, Eija Kalso, Maiju K. Marttinen
A multidisciplinary approach is the gold standard in the management of persistent pain and is current practice in tertiary pain clinics. However, such approaches seem to be a rarity in primary care, although pain is the most common reason for visiting a primary care physician. A comprehensive systematic review was conducted to explore whether studies on multidisciplinary management programs for persistent
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Risk of fibromyalgia following antibiotic prescriptions: A population-based case–control study Eur. J. Pain (IF 3.6) Pub Date : 2024-01-23 David Armstrong, Alex Dregan, Mark Ashworth, Patrick White
The health of the gut microbiome is now recognized to be an important component of the gut–brain axis which itself appears to be implicated in pain perception. Antibiotics are known to create dysbiosis in the microbiome, so whether fibromyalgia is more commonly diagnosed after antibiotic prescriptions provides a means of exploring the role of the microbiome in the experience of chronic pain.
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Assessment of the concordance between DN4 scores performed by the patient (self-assessment) or by the physician (hetero-assessment) to detect subacute neuropathic postoperative pain Eur. J. Pain (IF 3.6) Pub Date : 2024-01-19 Frédéric Adam, Gilles Chatellier, Pascal Alfonsi
Centres dedicated to chronic postsurgical pain (CPSP) have been developed, but delays for accessing to it are generally long. Teleconsultation might be a means to facilitate access to care by allowing an initial triage. CPSPs are neuropathic pain in around half of the cases and their diagnosis is mainly based on the score obtained from validated questionnaires. Among them, those requiring a neurological
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Neighbourhood socioeconomic status and pain among older adults—A cross-sectional study Eur. J. Pain (IF 3.6) Pub Date : 2024-01-12 Kenta Okuyama, Sven-Erik Johansson, Kristina Sundquist
Pain is associated with falls, disability and a poor quality of life among older adults. It is highly prevalent in many societies, and studies have shown that pain could be preventable or managed more effectively at the population level. However, few studies have investigated who is at higher risk of pain in the general population, which is important for development of effective interventions. The
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The costs of chronic pain—Long-term estimates Eur. J. Pain (IF 3.6) Pub Date : 2024-01-12 Audun Stubhaug, Johan Liseth Hansen, Sara Hallberg, Anders Gustavsson, Anne Elise Eggen, Christopher Sivert Nielsen
Chronic pain is a condition with severe impact on many aspects of life, including work, functional ability and quality of life, thereby reducing physical, mental and social well-being. Despite the high prevalence and burden of chronic pain, it has received disproportionally little attention in research and public policy and the societal costs of chronic pain remain largely unknown. This study aimed
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Psychological profiles and prescription opioid misuse, craving, and withdrawal in people with chronic pain Eur. J. Pain (IF 3.6) Pub Date : 2024-01-08 R. Esteve, V. Barrado-Moreno, C. Ramírez-Maestre, E. R. Serrano-Ibáñez, R. de la Vega, G. T. Ruiz-Párraga, G. Sainero-Tirado, M. Fernández Baena, M. Jensen, A. E. López-Martínez
The negative consequences of prescription opioid misuse and opioid use disorder make it relevant to identify factors associated with this problem in individuals with chronic pain. This cross-sectional study aimed at identifying subgroups of people with chronic pain based on their psychological profiles, prescription opioid misuse, craving, and withdrawal.
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Movement-evoked pain is not associated with pain at rest or physical function in knee osteoarthritis Eur. J. Pain (IF 3.6) Pub Date : 2024-01-08 José Antonio Lozano-Meca, Mariano Gacto-Sánchez, Joaquina Montilla-Herrador
Knee Osteoarthritis (KOA) is mainly characterized by pain. The assessment of KOA-related pain frequently focuses on different constructs subject to sources of bias or drawbacks, as the classical Pain at Rest (PAR). Movement-evoked pain (MEP), recently defined as ‘pain during walking’, emerges as a differential concept, since PAR and MEP are driven by different underlying mechanisms. Given the novelty
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Anxiety, history of childhood adversity, and experiencing chronic pain in adulthood: A systematic literature review and meta-analysis Eur. J. Pain (IF 3.6) Pub Date : 2024-01-08 Danielle E. Dalechek, Line Caes, Gwenne McIntosh, Anna C. Whittaker
When considering factors that may impact chronic pain experiences in adulthood, adverse childhood experiences (ACEs) and anxiety should be considered. The literature on the associations between these 3 variables remains unclear.
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Mendelian randomization study of lipid metabolism characteristics and migraine risk Eur. J. Pain (IF 3.6) Pub Date : 2024-01-06 Peiwei Hong, Lin Han, Yang Wan
The association between serum lipids and migraine is controversial. However, randomized controlled trials have suggested that statins may be efficacious for the prevention of migraine. In this study, we aim to investigate the relationship between lipids metabolism and migraine risk.
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Exploring biomarkers in trigeminal neuralgia patients operated with microvascular decompression: A comparison with multiple sclerosis patients and non-neurological controls Eur. J. Pain (IF 3.6) Pub Date : 2023-12-29 Muataz S. Lafta, Aleksandr V. Sokolov, Anne-Marie Landtblom, Hans Ericson, Helgi B. Schiöth, Sami Abu Hamdeh
Trigeminal neuralgia (TN) is a severe facial pain condition often associated with a neurovascular conflict. However, neuroinflammation has also been implicated in TN, as it frequently co-occurs with multiple sclerosis (MS).
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Fatigue can influence the development of late-onset pain in post-COVID-19 syndrome: An observational study Eur. J. Pain (IF 3.6) Pub Date : 2023-12-28 A. Baroni, G. Fregna, N. Lamberti, F. Manfredini, S. Straudi
Late-onset pain is frequent following COVID-19, and many pathogenetic mechanisms have been proposed. Identifying the main features of patients may help in designing tailored rehabilitative interventions.
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Social cues influence perception of others' pain Eur. J. Pain (IF 3.6) Pub Date : 2023-12-26 Lanlan Zhang, Tor D. Wager, Leonie Koban
Accurately perceiving other people's pain is important in both daily life and healthcare settings. However, judging other's pain is inherently difficult and can be biased by various social and cultural factors. Here, we examined whether perception of others' pain and pain management recommendations are socially influenced by seeing the opinions of other raters.
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Authors' reply to the comment by Alam et al. Eur. J. Pain (IF 3.6) Pub Date : 2023-12-27 L. Kjelgaard Pedersen, L. Y. V. Fisker, J. D. Rölfing, P. Ahlburg, M. Veien, L. Vase, B. Møller-Madsen
We appreciate the interest in our paper: ‘Virtual reality increases pressure pain threshold and lowers anxiety in children compared with control and non-immersive control—a randomized, crossover trial’ (Pedersen et al., 2023). The findings of our randomized controlled cross-over trial may partially explain why Virtual reality (VR) is effective in reducing pain in children and adolescents. We found
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The importance of context (placebo effects) in conservative interventions for musculoskeletal pain: A systematic review and meta-analysis of randomized controlled trials Eur. J. Pain (IF 3.6) Pub Date : 2023-12-20 Tobias Saueressig, Patrick J. Owen, Hugo Pedder, Scott Tagliaferri, Svenja Kaczorowski, Adina Altrichter, Antonia Richard, Clint T. Miller, Lars Donath, Daniel L. Belavy
Contextual effects (e.g. patient expectations) may play a role in treatment effectiveness. This study aimed to estimate the magnitude of contextual effects for conservative, non-pharmacological interventions for musculoskeletal pain conditions. A systematic review and meta-analysis of randomized controlled trials (RCTs) that compared placebo conservative non-pharmacological interventions to no treatment
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Change in pain expectations but no open-label placebo analgesia: An experimental study using the heat pain paradigm Eur. J. Pain (IF 3.6) Pub Date : 2023-12-18 Thilo Friehs, Christopher Milde, Julia Anna Glombiewski, Tobias Kube
Open-label placebos (OLP) prescribed without deception and with a convincing rationale have been shown to evoke powerful treatment effects. Patients’ treatment expectations seem to influence the magnitude of the effect.
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Long-term postoperative opioid use in orthopaedic patients Eur. J. Pain (IF 3.6) Pub Date : 2023-12-18 Eward J. Melis, Johanna E. Vriezekolk, Julian C. C. van der Laan, José M. H. Smolders, Bart J. F. van den Bemt, Maaike G. E. Fenten
The prevalence of long-term opioid use after orthopaedic surgery varies from 1.4% to 24% and has mostly been studied with prescription data, making it difficult to estimate the size and impact of the problem. This study aims to assess the prevalence and predictors of long-term postoperative opioid use in a high volume and tertiary orthopaedic centre by using online patient reported measures.
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Autonomic nervous system function assessed by heart rate variability and the presence of symptoms affecting activities of daily living in community-dwelling residents with chronic pain: The Hisayama Study Eur. J. Pain (IF 3.6) Pub Date : 2023-12-16 Yuri Nakamura, Mao Shibata, Yukiko Morisaki, Naoki Hirabayashi, Mayu Higashioka, Jun Hata, Masako Hosoi, Nobuyuki Sudo, Ken Yamaura, Toshiharu Ninomiya
Autonomic nervous system dysfunction has been reported to be associated with impaired activities of daily living (ADL) among patients with chronic pain, but the association has not been fully addressed in general populations. This study cross-sectionally investigated the association between autonomic nervous system function and the presence of subjective symptoms affecting ADL in community-dwelling
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Picturing oneself over time: a multi-modal interpretative phenomenological analysis of pain management trajectories Eur. J. Pain (IF 3.6) Pub Date : 2023-12-15 I. E. Nizza, J. A. Smith, J. A. Kirkham
Chronic pain (CP) can be a disabling condition with impacts that affect the sense of identity of those who live with it. This article idiographically describes the longitudinal evolution of the sense of self of participants following their referral to a pain management service and participation in a pain management programme (PMP).
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A two-component model of hair cortisol concentration in fibromyalgia: Independent effects of pain chronicity and severity Eur. J. Pain (IF 3.6) Pub Date : 2023-12-15 G. A. Reyes del Paso, A. Garcia-Hernandez, A. M. Contreras-Merino, C. M. Galvez-Sánchez, P. de la Coba, C. I. Montoro, D. M. Davydov
Fibromyalgia (FM) is a chronic pain disorder of unknown aetiopathogenesis, in which the role of activity of the hypothalamic–pituitary–adrenal (HPA) axis is not clearly established.
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Association between central sensitization, pain sensitivity and balance control in patients with migraine Eur. J. Pain (IF 3.6) Pub Date : 2023-12-15 A. Sennholz, T. M. Szikszay, T. Marusich, K. Luedtke, G. F. Carvalho
Balance alterations are prevalent among pain conditions, including migraine. The mechanisms explaining the association between pain and balance are unclear, as well as whether levels of pain sensitivity correlate with impaired balance. Our aim was therefore to investigate the association between balance, central sensitization symptoms and pain sensitivity in patients with migraine.
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Rethinking placebo: Exploring the effectiveness of open-label placebos Eur. J. Pain (IF 3.6) Pub Date : 2023-12-15 Przemysław Bąbel
This journal recently published a paper by Druart et al. (2023), ‘If only they knew! A non-inferiority randomized controlled trial comparing deceptive and open-label placebo in healthy individuals’. The study presents the first evidence suggesting that open-label placebos (OLP) may be as effective as deceptive placebos (DP) in alleviating pain. This discovery calls for replication and deeper investigation
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Social support of virtual characters reduces pain perception Eur. J. Pain (IF 3.6) Pub Date : 2023-12-13 I. Neumann, M. Andreatta, P. Pauli, I. Käthner
Psychosocial factors, such as social support, can reduce pain. Virtual reality (VR) is a powerful tool to decrease pain, but social factors in VR-based pain analgesia have rarely been studied. Specifically, it is unclear whether social support by virtual characters can reduce pain and whether the perceived control behind virtual characters (agency) and varying degrees of social cues impact pain perception
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The effect of self-management techniques on relevant outcomes in chronic low back pain: A systematic review and meta-analysis Eur. J. Pain (IF 3.6) Pub Date : 2023-12-09 C. Scholz, P. Schmigalle, C. Y. Plessen, G. Liegl, P. Vajkoczy, F. Prasser, M. Rose, A. Obbarius
Among many treatment approaches for chronic low back pain (CLBP), self-management techniques are becoming increasingly important. The aim of this paper was to (a) provide an overview of existing digital self-help interventions for CLBP and (b) examine the effect of these interventions in reducing pain intensity, pain catastrophizing and pain disability.
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Sociodemographic disparities and potential biases in persistent pain estimates: Findings from 5 waves of the Irish Longitudinal Study on Ageing (TILDA) Eur. J. Pain (IF 3.6) Pub Date : 2023-12-07 E. Ryan, A. Hannigan, H. Grol-Prokopczyk, P. May, H. Purtill
Pain is a prevalent, debilitating condition among older adults. Much evidence on this topic comes from cohort studies, which may be affected by attrition and measurement bias. Little is known about the impact of these biases on pain estimates for European older adults. Additionally, there is a lack of longitudinal research on pain and sociodemographic disparities in Irish older adults.
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Distortions to the passage of time during chronic pain: A mixed method study Eur. J. Pain (IF 3.6) Pub Date : 2023-11-30 Ruth Ogden, David Moore, Andrea Piovesan, Helen Poole
A core aspect of the clinical assessment of pain is establishing how long pain has been present for. The reported length of pain can therefore influence diagnosis and treatment. Despite this, little is known about how chronic pain affects the passage of time.
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Cerebellar somatotopy of the trigemino-cervical complex during nociception Eur. J. Pain (IF 3.6) Pub Date : 2023-11-28 Hauke Basedau, Arne May, Jan Mehnert
The somatotopic organization of the human cerebellum processes somato-motoric input. Its role during pain perception for nociceptive input remains ambiguous. A standardized experimental trigeminal nociceptive input in functional imaging might clarify the role of the cerebellum in trigeminal nociception. Also of interest is the greater occipital nerve, which innervates the back of the head, and can
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Morphological changes of the limbic system associated with acute and chronic low-back pain: A UK biobank imaging study Eur. J. Pain (IF 3.6) Pub Date : 2023-11-27 Valeria Sacca, Thalia Celeste Chai-Zhang, Sierra Hodges, Judith Amores, Seyhmus Guler, Nevyana Todorova, Caroline Merritt McDonald, Tian Ge, Jian Kong
Low back pain (LBP) is a major public health issue that influences physical and emotional factors integral to the limbic system. This study aims to investigate the association between LBP and brain morphometry alterations as the duration of LBP increases (acute vs. chronic).
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The evolving landscape of publishing in the field of pain: An automated bibliometric analysis from 1975 to 2020 Eur. J. Pain (IF 3.6) Pub Date : 2023-11-27 L. Arendt-Nielsen, J. T. Pedersen, S. Dreier, T. A. Nielsen, A. L. Høj, L. Thomsen
The aims of this bibliometric analysis were (1) a longitudinal analysis of the publication landscape in the field of pain (1975–2020) and (2) to characterize the overall publication profiles for two selected journals: European Journal of Pain and PAIN® utilizing an automated approach.
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How do we explain painful non-traumatic knee conditions to adolescents? A multiple-method study to develop credible explanations Eur. J. Pain (IF 3.6) Pub Date : 2023-11-21 C. Djurtoft, M. K. Bruun, H. Riel, M. S. Hoegh, B. Darlow, M. S. Rathleff
Perceived diagnostic uncertainty can leave adolescents confused about their condition and impede their ability to understand “what's wrong with me”. Our aim is to develop credible explanations about the condition for adolescents suffering from non-traumatic knee pain.
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Contextual factors in persistent severe back pain: A longitudinal analysis among German employees Eur. J. Pain (IF 3.6) Pub Date : 2023-11-22 Julia-Marie Zimmer, David Fauser, André Golla, Matthias Bethge, Wilfried Mau
Chronic back pain in employees compromises participation in social and daily activities, as well as work.
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The role of stigma in health and functioning in chronic pain: Not just catastrophizing Eur. J. Pain (IF 3.6) Pub Date : 2023-11-20 Amani Lavefjord, F. T. A. Sundström, M. Buhrman, L. M. McCracken
People with chronic pain are frequently exposed to stigma, which is typically distressing and may lead to internal stigmatizing thoughts. The thought content associated with stigma has similarities to pain catastrophizing, although these concepts differ in that stigma is arguably more social in origin. Stigma can be measured by the Stigma Scale for Chronic Illness – 8-item version (SSCI-8). In this
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Placebo analgesia in physical and psychological interventions: Systematic review and meta-analysis of three-armed trials Eur. J. Pain (IF 3.6) Pub Date : 2023-11-20 David Hohenschurz-Schmidt, Jules Phalip, Jessica Chan, Greta Gauhe, Nadia Soliman, Jan Vollert, Sigrid Juhl Lunde, Lene Vase
The magnitude of placebo effects from physical and psychological ‘sham’ is unknown but could impact efficacy trials and treatment understanding. To quantify placebo effects, this systematic review of three-armed randomised controlled trials (RCTs) of physical and psychological interventions for pain compared outcomes in ‘sham’ control intervention and non-exposure arms.
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CFA-treated mice induce hyperalgesia in healthy mice via an olfactory mechanism Eur. J. Pain (IF 3.6) Pub Date : 2023-11-20 Yangmiao Zhang, Wentai Luo, Mary M. Heinricher, Andrey E. Ryabinin
Social interactions with subjects experiencing pain can increase nociceptive sensitivity in observers, even without direct physical contact. In previous experiments, extended indirect exposure to soiled bedding from mice with alcohol withdrawal-related hyperalgesia enhanced nociception in their conspecifics. This finding suggested that olfactory cues could be sufficient for nociceptive hypersensitivity
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Correlation between migraine and cerebral small vessel disease: A case–control study Eur. J. Pain (IF 3.6) Pub Date : 2023-11-20 Yanan Zhang, Yanbo Li, Li He
Microcirculatory pathology is one of the pathophysiological theories of migraine, which may present as visually subclinical lesions. Image markers of cerebral small vessel disease (CSVD) have been investigated in elderly migraineurs. However, past studies looked at only part of image features, and the conclusions may have been hindered by confounding factors. The relationship between migraine and CSVD
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It takes two: The relative contributions of parent versus child-led regulatory behaviours on toddler vaccination pain Eur. J. Pain (IF 3.6) Pub Date : 2023-11-20 H. G. Gennis, D. B. Flora, C. M. McMurtry, D. Flanders, E. Weinberg, D. Savlov, H. Garfield, R. Pillai Riddell
Past research has established the important role of parent soothing in early childhood pain management. However, limited research has assessed children's own emerging emotion regulation strategies to reduce their pain during vaccination. The purpose of the current study was to understand the relative contributions of child-led emotion-regulation behaviours over and above parent regulatory behaviours
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Effects of cervical stabilization training in patients with headache: A single-blinded randomized controlled trial Eur. J. Pain (IF 3.6) Pub Date : 2023-11-16 H. Altmis Kacar, C. Ozkul, A. Baran, A. Guclu-Gunduz
This study aimed to investigate the effects of Cervical Stabilization Training (CST) on the headache, neck pain and cervical musculoskeletal system in patients with headache compared to the control group.
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The long-term incidence of chronic post-surgical pain after coronary artery bypass surgery – A prospective observational study Eur. J. Pain (IF 3.6) Pub Date : 2023-11-15 E. Charlton, K. J. Atkins, L. Evered, B. Silbert, D. A. Scott
Chronic post-surgical pain (CPSP) represents a significant issue for many patients following surgery; however, the long-term incidence and impact have not been well described following cardiac surgery. Our aim was to characterize CPSP at least 5 years following coronary artery bypass grafting (CABG) surgery.
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If only they knew! A non-inferiority randomized controlled trial comparing deceptive and open-label placebo in healthy individuals Eur. J. Pain (IF 3.6) Pub Date : 2023-11-15 L. Druart, S. E. Graham Longsworth, H. Terrisse, C. Locher, C. Blease, C. Rolland, N. Pinsault
Placebo use is widespread in clinical practice. However, they are most often administered deceptively rather than openly. It is often suggested that open-label placebos (OLP) are less effective than deceptive placebos (DP). This study aimed to compare the use of DP and OLP treatments to reduce pain in healthy volunteers.
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Cervical muscle parameters and allodynia in migraine and cervical pain—A controlled study Eur. J. Pain (IF 3.6) Pub Date : 2023-11-09 A. Rodrigues, L. M. Bigal, M. M. Bragatto, F. Dach, D. Bevilaqua-Grossi, M. E. Bigal, C. Fernández-de-las-Peñas, L. L. Florencio
Neck pain is common among individuals with migraine, but there is a lack of information of how this comorbidity can be associated with cervical muscle function. This controlled cross-sectional study aimed to compare cervical muscle function, activity, and sensitization in women with migraine, neck pain, both, and neither.
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Early versus persistent Complex Regional Pain Syndrome: Is there a difference in patient reported outcomes following rehabilitation? Eur. J. Pain (IF 3.6) Pub Date : 2023-11-10 Jennifer S. Lewis, Chris S. Wallace, Paul White, Laura Mottram, Gareth Ockenden, Kjetil Rehm, Kate Walker
Expert consensus asserts that early treatment of Complex Regional Pain Syndrome (CRPS) leads to better outcomes. Yet no evidence supports this assumption regarding the recognized gold standard of multidisciplinary functional rehabilitation. To address this, we aimed to establish if there is a difference in outcomes between early CRPS (<1 year symptom duration) and persistent CRPS (= >1 year symptom
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Intramuscular injections of botulinum toxin for the treatment of upper back myofascial pain syndrome: A systematic review of randomized controlled trials Eur. J. Pain (IF 3.6) Pub Date : 2023-11-10 G. Leonardi, A. Alito, S. Portaro, B. Di Matteo, S. Respizzi, E. Kon, G. Massazza, C. Sconza
Myofascial pain syndrome (MPS) is a chronic musculoskeletal disorder characterized by the presence of trigger points. Among the treatment options, botulinum toxin injections have been investigated. The aim of this paper was to provide a synthesis of the evidence on intramuscular botulinum toxin injections for upper back MPS.
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Opioid dose titration for cancer pain Eur. J. Pain (IF 3.6) Pub Date : 2023-11-10 Sebastiano Mercadante
Opioid dose titration is a fundamental process of opioid therapy in cancer pain.