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DLPFC volume is a neural correlate of resilience in healthy high-risk individuals with both childhood maltreatment and familial risk for depression Psychol. Med. (IF 5.813) Pub Date : 2021-04-16 Katharina Brosch, Frederike Stein, Tina Meller, Simon Schmitt, Dilara Yuksel, Kai Gustav Ringwald, Julia-Katharina Pfarr, Lena Waltemate, Hannah Lemke, Nils Opel, Susanne Meinert, Katharina Dohm, Dominik Grotegerd, Janik Goltermann, Jonathan Repple, Alexandra Winter, Andreas Jansen, Udo Dannlowski, Igor Nenadić, Tilo Kircher, Axel Krug
Background Two prominent risk factors for major depressive disorder (MDD) are childhood maltreatment (CM) and familial risk for MDD. Despite having these risk factors, there are individuals who maintain mental health, i.e. are resilient, whereas others develop MDD. It is unclear which brain morphological alterations are associated with this kind of resilience. Interaction analyses of risk and diagnosis
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Efficacy of an integrative approach for bipolar disorder: preliminary results from a randomized controlled trial Psychol. Med. (IF 5.813) Pub Date : 2021-04-16 Èlia Valls, C. Mar Bonnín, Imma Torres, Mercè Brat, Mireia Prime-Tous, Ivette Morilla, Xavier Segú, Brisa Solé, Carla Torrent, Eduard Vieta, Anabel Martínez-Arán, María Reinares, José Sánchez-Moreno
Background Bipolar disorder (BD) represents one of the most therapeutically complex psychiatric disorders. The development of a feasible comprehensive psychological approach to complement pharmacotherapy to improve its clinical management is required. The main objective of the present randomized controlled trial (RCT) was to test the efficacy of a novel adjunctive treatment entitled integrative approach
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Stimulus valence, episodic memory, and the priming of brain activation profiles in borderline personality disorder Psychol. Med. (IF 5.813) Pub Date : 2021-04-16 Morgan Szczepaniak, Asadur Chowdury, Paul H. Soloff, Vaibhav A. Diwadkar
Background Borderline personality disorder (BPD) is characterized by instability in affective regulation that can result in a loss of cognitive control. Triggers may be neuronal responses to emotionally valenced context and/or stimuli. ‘Neuronal priming’ indexes the familiarity of stimuli, and may capture the obligatory effects of affective valence on the brain's processing system, and how such valence
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A systematic review of adherence to group interventions in psychosis: do people attend? Psychol. Med. (IF 5.813) Pub Date : 2021-04-16 Ottilie Sedgwick, Amy Hardy, Katie Newbery, Matteo Cella
Background Evidence supports the use of group therapy for symptom reduction and improving functioning in people with psychosis. However, research guidelines highlight the importance of establishing the feasibility of interventions. Adherence is an important indicator of feasibility and an essential step in supporting the development of the evidence base for group interventions. This review aims to
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Antipsychotic treatment and risk of discontinuation and hospitalization in first-episode schizophrenia: a nationwide population-based study Psychol. Med. (IF 5.813) Pub Date : 2021-04-15 Sung Woo Joo, Harin Kim, Young Tak Jo, Young Jae Choi, Soojin Ahn, Jungsun Lee
Background Current evidence on antipsychotic treatment and risk of psychiatric hospitalization in first-episode schizophrenia (FES) is largely based on the findings from randomized clinical trials (RCTs). However, the generalization of the findings to real-world patients is limited due to inherent caveats of the RCT. We aimed to investigate the treatment discontinuation and risk of psychiatric hospitalization
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Auditory discrimination and frequency modulation learning in schizophrenia patients: amphetamine within-subject dose response and time course Psychol. Med. (IF 5.813) Pub Date : 2021-04-14 Neal R. Swerdlow, Savita G. Bhakta, Jo Talledo, Lindsay Benster, Juliana Kotz, Sophia Vinogradov, Juan L. Molina, Gregory A. Light
Background Auditory frequency modulation learning (‘auditory learning’) is a key component of targeted cognitive training (TCT) for schizophrenia. TCT can be effective in enhancing neurocognition and function in schizophrenia, but such gains require significant time and effort and elude many patients. Methods As a strategy to increase and/or accelerate TCT-induced clinical gains, we tested the dose-
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The contribution of depressive ‘disorder characteristics’ to determinations of prognosis for adults with depression: an individual patient data meta-analysis Psychol. Med. (IF 5.813) Pub Date : 2021-04-14 Joshua E. J. Buckman, Rob Saunders, Zachary D. Cohen, Phoebe Barnett, Katherine Clarke, Gareth Ambler, Robert J. DeRubeis, Simon Gilbody, Steven D. Hollon, Tony Kendrick, Edward Watkins, Nicola Wiles, David Kessler, David Richards, Deborah Sharp, Sally Brabyn, Elizabeth Littlewood, Chris Salisbury, Ian R. White, Glyn Lewis, Stephen Pilling
Background This study aimed to investigate general factors associated with prognosis regardless of the type of treatment received, for adults with depression in primary care. Methods We searched Medline, Embase, PsycINFO and Cochrane Central (inception to 12/01/2020) for RCTs that included the most commonly used comprehensive measure of depressive and anxiety disorder symptoms and diagnoses, in primary
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Effectiveness of cognitive remediation in depression: a meta-analysis Psychol. Med. (IF 5.813) Pub Date : 2021-04-14 Amanda M. Legemaat, Maria Semkovska, Marlies Brouwer, Gert J. Geurtsen, Huibert Burger, Damiaan Denys, Claudi L. Bockting
Background Preliminary evidence suggests beneficial effects of cognitive remediation in depression. An update of the current evidence is needed. The aim was to systematically assess the effectiveness of cognitive remediation in depression on three outcomes. Methods The meta-analysis was pre-registered on PROSPERO (CRD42019124316). PubMed, PsycINFO, Embase and Cochrane Library were searched on 2 February
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Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease Psychol. Med. (IF 5.813) Pub Date : 2021-04-14 Fabienne Cyprien, Claudine Berr, Jerome J. Maller, Chantal Meslin, Mélissa Gentreau, Thibault Mura, Audrey Gabelle, Philippe Courtet, Karen Ritchie, Marie-Laure Ancelin, Sylvaine Artero
Background Cynical hostility (CH), a specific dimension of hostility that consists of a mistrust of others, has been suggested as a high-risk trait for dementia. However, the influence of CH on the incidence of Alzheimer's disease (AD) remains poorly understood. This study investigated whether late-life CH is associated with AD risk and structural neuroimaging markers of AD. Methods In community-dwelling
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Post-traumatic stress disorder as a predictor for incident hypertension: a 3-year retrospective cohort study Psychol. Med. (IF 5.813) Pub Date : 2021-04-14 Victoria Mendlowicz, Maria Luiza Garcia-Rosa, Marcio Gekker, Larissa Wermelinger, William Berger, Mariana Pires de Luz, Paulo Roberto Telles Pires-Dias, Carla Marques-Portela, Ivan Figueira, Mauro Vitor Mendlowicz
Background The goal of the present study was to investigate the association between PTSD and the onset of hypertension in previously normotensive individuals in a population living in the stressful environment of the urban slums while controlling for risk factors for cardiovascular disease (CVD). Methods Participants were 320 normotensive individuals who lived in slums and were attending a family doctor
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Prevalence of internalizing disorders, symptoms, and traits across age using advanced nonlinear models Psychol. Med. (IF 5.813) Pub Date : 2021-04-14 Hanna M. van Loo, Lian Beijers, Martijn Wieling, Trynke R. de Jong, Robert A. Schoevers, Kenneth S. Kendler
Background Most epidemiological studies show a decrease of internalizing disorders at older ages, but it is unclear how the prevalence exactly changes with age, and whether there are different patterns for internalizing symptoms and traits, and for men and women. This study investigates the impact of age and sex on the point prevalence across different mood and anxiety disorders, internalizing symptoms
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Psychiatric comorbidity as predictor and moderator of binge-eating disorder treatment outcomes: an analysis of aggregated randomized controlled trials Psychol. Med. (IF 5.813) Pub Date : 2021-04-14 Janet A. Lydecker, Carlos M. Grilo
Background Psychiatric comorbidity is common in binge-eating disorder (BED) but effects on treatment outcomes are unknown. The current study aimed to determine whether psychiatric comorbidity predicted or moderated BED treatment outcomes. Methods In total, 636 adults with BED in randomized-controlled trials (RCTs) were assessed prior, throughout, and posttreatment by doctoral research-clinicians using
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Thirty-year outcome of anxiety and depressive disorders and personality status: comprehensive evaluation of mixed symptoms and the general neurotic syndrome in the follow-up of a randomised controlled trial Psychol. Med. (IF 5.813) Pub Date : 2021-04-12 Peter Tyrer, Helen Tyrer, Tony Johnson, Min Yang
Background Cohort studies of the long-term outcome of anxiety, depression and personality status rarely join together. Methods Two hundred and ten patients recruited with anxiety and depression to a randomised controlled trial between 1983 and 1987 (Nottingham Study of Neurotic Disorder) were followed up over 30 years. At trial entry personality status was assessed, together with the general neurotic
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What is a mental disorder? An exemplar-focused approach Psychol. Med. (IF 5.813) Pub Date : 2021-04-12 Dan J. Stein, Andrea C. Palk, Kenneth S. Kendler
The question of ‘what is a mental disorder?’ is central to the philosophy of psychiatry, and has crucial practical implications for psychiatric nosology. Rather than approaching the problem in terms of abstractions, we review a series of exemplars – real-world examples of problematic cases that emerged during work on and immediately after DSM-5, with the aim of developing practical guidelines for addressing
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Pregnancy during the pandemic: the impact of COVID-19-related stress on risk for prenatal depression Psychol. Med. (IF 5.813) Pub Date : 2021-03-30 Lucy S. King, Daisy E. Feddoes, Jaclyn S. Kirshenbaum, Kathryn L. Humphreys, Ian H. Gotlib
Background Pregnant women may be especially susceptible to negative events (i.e. adversity) related to the coronavirus disease 2019 (COVID-19) pandemic and negative affective responses to these events (i.e. stress). We examined the latent structure of stress and adversity related to the COVID-19 pandemic among pregnant women, potential antecedents of COVID-19-related stress and adversity in this population
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Continuum beliefs and mental illness stigma: a systematic review and meta-analysis of correlation and intervention studies Psychol. Med. (IF 5.813) Pub Date : 2021-04-08 Lina-Jolien Peter, Stephanie Schindler, Christian Sander, Silke Schmidt, Holger Muehlan, Thomas McLaren, Samuel Tomczyk, Sven Speerforck, Georg Schomerus
Background Promulgating a continuum model of mental health and mental illness has been proposed as a way to reduce stigma by decreasing notions of differentness. This systematic review and meta-analysis examines whether continuum beliefs are associated with lower stigma, and whether continuum interventions reduce stigma. Methods Following a pre-defined protocol (PROSPERO: CRD42019123606), we searched
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Effects of polygenic risk for major mental disorders and cross-disorder on cortical complexity Psychol. Med. (IF 5.813) Pub Date : 2021-04-08 Simon Schmitt, Tina Meller, Frederike Stein, Katharina Brosch, Kai Ringwald, Julia-Katharina Pfarr, Clemens Bordin, Nina Peusch, Olaf Steinsträter, Dominik Grotegerd, Katharina Dohm, Susanne Meinert, Katharina Förster, Ronny Redlich, Nils Opel, Tim Hahn, Andreas Jansen, Andreas J. Forstner, Fabian Streit, Stephanie H. Witt, Marcella Rietschel, Bertram Müller-Myhsok, Markus M. Nöthen, Udo Dannlowski
Background MRI-derived cortical folding measures are an indicator of largely genetically driven early developmental processes. However, the effects of genetic risk for major mental disorders on early brain development are not well understood. Methods We extracted cortical complexity values from structural MRI data of 580 healthy participants using the CAT12 toolbox. Polygenic risk scores (PRS) for
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Examining the association between childhood autistic traits and adolescent hypomania: a longitudinal twin study Psychol. Med. (IF 5.813) Pub Date : 2021-04-08 Mark J. Taylor, Angelica Ronald, Joanna Martin, Sebastian Lundström, Georgina M. Hosang, Paul Lichtenstein
Background There is evidence that autism spectrum disorders (ASDs) co-occur with bipolar disorder (BD) relatively frequently. Individuals with BD often report symptoms of mania and hypomania during adolescence, prior to the age of onset for BD. It is unknown whether these symptoms are associated with ASDs. We examined whether diagnoses of ASDs and autistic traits were associated with hypomania in a
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Intergenerational transmission of suicide attempt in a cohort of 4.4 million children Psychol. Med. (IF 5.813) Pub Date : 2021-04-08 Anne Ranning, Md Jamal Uddin, Holger J. Sørensen, Thomas Munk Laursen, Anne A. E. Thorup, Trine Madsen, Merete Nordentoft, Annette Erlangsen
Background The association between suicide attempts (SAs) in parents and children is unclear, and risk indicators for intergenerational transmission remain undocumented. We aimed to assess this association, considering the child's developmental period at the time of parents' attempted suicide, and the parental relation. Methods Using a prospective cohort design, nationwide population data were linked
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The role of characterisation in everyday voice engagement and AVATAR therapy dialogue Psychol. Med. (IF 5.813) Pub Date : 2021-04-08 Thomas Ward, Rachel Lister, Miriam Fornells-Ambrojo, Mar Rus-Calafell, Clementine J. Edwards, Conan O'Brien, Tom KJ Craig, Philippa Garety
Background Voices are commonly experienced as communication with a personified ‘other’ with ascribed attitudes, intentionality and personality (their own ‘character’). Phenomenological work exploring voice characterisation informs a new wave of relational therapies. To date, no study has investigated the role of characterisation in behavioural engagement with voices or within psychological therapy
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Effects of dietary interventions on depressive symptom profiles: results from the MooDFOOD depression prevention study Psychol. Med. (IF 5.813) Pub Date : 2021-04-07 Sarah R. Vreijling, Brenda W. J. H. Penninx, Mariska Bot, Ed Watkins, Matthew Owens, Elisabeth Kohls, Ulrich Hegerl, Miquel Roca, Margalida Gili, Ingeborg A. Brouwer, Marjolein Visser, Aartjan T. F. Beekman, Rick Jansen, Femke Lamers
Background Dietary interventions did not prevent depression onset nor reduced depressive symptoms in a large multi-center randomized controlled depression prevention study (MooDFOOD) involving overweight adults with subsyndromal depressive symptoms. We conducted follow-up analyses to investigate whether dietary interventions differ in their effects on depressive symptom profiles (mood/cognition; somatic;
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Trajectories of psychological distress among individuals exposed to the 9/11 World Trade Center disaster Psychol. Med. (IF 5.813) Pub Date : 2021-04-07 Tomohiro M. Ko, Howard E. Alper, Robert H. Brackbill, Melanie H. Jacobson
Background Individuals present in lower Manhattan during the 9/11 World Trade Center (WTC) disaster suffered from significant physical and psychological trauma. Studies of longitudinal psychological distress among those exposed to trauma have been limited to relatively short durations of follow-up among smaller samples. Methods The current study longitudinally assessed heterogeneity in trajectories
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Insights into attention-deficit/hyperactivity disorder from recent genetic studies Psychol. Med. (IF 5.813) Pub Date : 2021-04-05 Isabell Brikell, Christie Burton, Nina Roth Mota, Joanna Martin
Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable neurodevelopmental disorder (NDD). In this narrative review, we summarize recent advances in quantitative and molecular genetic research from the past 5–10 years. Combined with large-scale international collaboration, these advances have resulted in fast-paced progress in understanding the etiology of ADHD and how genetic
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Coronavirus conspiracy beliefs in the German-speaking general population: endorsement rates and links to reasoning biases and paranoia Psychol. Med. (IF 5.813) Pub Date : 2021-03-16 Sarah Anne Kezia Kuhn, Roselind Lieb, Daniel Freeman, Christina Andreou, Thea Zander-Schellenberg
Background Coronavirus-related conspiracy theories (CT) have been found to be associated with fewer pandemic containment-focused behaviors. It is therefore important to evaluate associated cognitive factors. We aimed to obtain first endorsement rate estimates of coronavirus-related conspiracy beliefs in a German-speaking general population sample and investigate whether delusion-related reasoning biases
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Suicide and the agent–host–environment triad: leveraging surveillance sources to inform prevention Psychol. Med. (IF 5.813) Pub Date : 2021-03-05 Katherine M. Keyes, Sasikiran Kandula, Mark Olfson, Madelyn S. Gould, Gonzalo Martínez-Alés, Caroline Rutherford, Jeffrey Shaman
Suicide in the US has increased in the last decade, across virtually every age and demographic group. Parallel increases have occurred in non-fatal self-harm as well. Research on suicide across the world has consistently demonstrated that suicide shares many properties with a communicable disease, including person-to-person transmission and point-source outbreaks. This essay illustrates the communicable
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Changes in peripheral blood compounds following psychopharmacological treatment in drug-naïve first-episode patients with either schizophrenia or major depressive disorder: a meta-analysis Psychol. Med. (IF 5.813) Pub Date : 2021-03-03 Nuray Çakici, Arjen L. Sutterland, Brenda W. J. H. Penninx, Lieuwe de Haan, Nico J. M. van Beveren
Background This meta-analysis on peripheral blood compounds in drug-naïve first-episode patients with either schizophrenia or major depressive disorder (MDD) examined which compounds change following psychopharmacological treatment. Methods The Embase, PubMed and PsycINFO databases were systematically searched for longitudinal studies reporting measurements of blood compounds in drug-naïve first-episode
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Causal inference with observational data: the need for triangulation of evidence Psychol. Med. (IF 5.813) Pub Date : 2021-03-08 Gemma Hammerton, Marcus R. Munafò
The goal of much observational research is to identify risk factors that have a causal effect on health and social outcomes. However, observational data are subject to biases from confounding, selection and measurement, which can result in an underestimate or overestimate of the effect of interest. Various advanced statistical approaches exist that offer certain advantages in terms of addressing these
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How does the COVID-19 pandemic impact on population mental health? A network analysis of COVID influences on depression, anxiety and traumatic stress in the UK population Psychol. Med. (IF 5.813) Pub Date : 2021-03-16 Orestis Zavlis, Sarah Butter, Kate Bennett, Todd K. Hartman, Philip Hyland, Liam Mason, Orla McBride, Jamie Murphy, Jilly Gibson-Miller, Liat Levita, Anton P. Martinez, Mark Shevlin, Thomas V. A. Stocks, Frédérique Vallières, Richard P. Bentall
Background The coronavirus disease 2019 (COVID-19) emergency has led to numerous attempts to assess the impact of the pandemic on population mental health. The findings indicate an increase in depression and anxiety but have been limited by the lack of specificity about which aspects of the pandemic (e.g. viral exposure or economic threats) have led to adverse mental health outcomes. Methods Network
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Altered activation and functional connectivity in individuals with social anhedonia when envisioning positive future episodes Psychol. Med. (IF 5.813) Pub Date : 2021-03-29 Zhuo-ya Yang, Rui-ting Zhang, Yong-ming Wang, Jia Huang, Han-yu Zhou, Eric F. C. Cheung, Raymond C. K. Chan
Background Anticipatory pleasure deficits are closely correlated with negative symptoms in schizophrenia, and may be found in both clinical and subclinical populations along the psychosis continuum. Prospection, which is an important component of anticipatory pleasure, is impaired in individuals with social anhedonia (SocAnh). In this study, we examined the neural correlates of envisioning positive
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Association between psychomotor disturbance and treatment outcome in psychotic depression: a STOP-PD II report Psychol. Med. (IF 5.813) Pub Date : 2021-03-26 Alastair J. Flint, Kathleen S. Bingham, Nicholas H. Neufeld, George S. Alexopoulos, Benoit H. Mulsant, Anthony J. Rothschild, Ellen M. Whyte, Aristotle N. Voineskos, Patricia Marino, Barnett S. Meyers, on behalf of the STOP-PD II Study Group
Background Little is known about the relationship between psychomotor disturbance (PMD) and treatment outcome of psychotic depression. This study examined the association between PMD and subsequent remission and relapse of treated psychotic depression. Methods Two hundred and sixty-nine men and women aged 18–85 years with an episode of psychotic depression were treated with open-label sertraline plus
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Associations and limited shared genetic aetiology between bipolar disorder and cardiometabolic traits in the UK Biobank Psychol. Med. (IF 5.813) Pub Date : 2021-03-26 Anna E. Fürtjes, Jonathan R. I. Coleman, Jess Tyrrell, Cathryn M. Lewis, Saskia P. Hagenaars
Background People with bipolar disorder (BPD) are more likely to die prematurely, which is partly attributed to comorbid cardiometabolic traits. Previous studies report cardiometabolic abnormalities in BPD, but their shared aetiology remains poorly understood. This study examined the phenotypic associations and shared genetic aetiology between BPD and various cardiometabolic traits. Methods In a subset
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Columbia-Suicide Severity Rating Scale Screen Version: initial screening for suicide risk in a psychiatric emergency department Psychol. Med. (IF 5.813) Pub Date : 2021-03-26 Johan Bjureberg, Marie Dahlin, Andreas Carlborg, Hanna Edberg, Axel Haglund, Bo Runeson
Background Suicide screening is routine practice in psychiatric emergency (PE) departments, but evidence for screening instruments is sparse. Improved identification of nascent suicide risk is important for suicide prevention. The aim of the current study was to evaluate the association between the novel Colombia Suicide Severity Rating Scale Screen Version (C-SSRS Screen) and subsequent clinical management
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Developmental trajectories of ADHD symptoms in a large population-representative longitudinal study Psychol. Med. (IF 5.813) Pub Date : 2021-03-26 Aja Louise Murray, Hildigunnur Anna Hall, Lydia Gabriela Speyer, Lara Carter, Daniel Mirman, Arthur Caye, Luis Rohde
Background Previous research has suggested that there is substantial heterogeneity in the developmental trajectories of attention-deficit/hyperactivity disorder (ADHD) symptoms. Sometimes, qualitative distinctions between trajectories with different ages of onset and/or patterns of remission are made; however, little is known about the predictors and broader clinical meaningfulness of these candidate
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Efficacy of attention bias modification training for depressed adults: a randomized clinical trial Psychol. Med. (IF 5.813) Pub Date : 2021-03-26 Kean J. Hsu, Jason Shumake, Kayla Caffey, Semeon Risom, Jocelyn Labrada, Jasper A. J. Smits, David M. Schnyer, Christopher G. Beevers
Background This study examined the efficacy of attention bias modification training (ABMT) for the treatment of depression. Methods In this randomized clinical trial, 145 adults (77% female, 62% white) with at least moderate depression severity [i.e. self-reported Quick Inventory of Depressive Symptomatology (QIDS-SR) ⩾13] and a negative attention bias were randomized to active ABMT, sham ABMT, or
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The long shadow of childhood trauma for depression in midlife: examining daily psychological stress processes as a persistent risk pathway Psychol. Med. (IF 5.813) Pub Date : 2021-03-26 Stefanie E. Mayer, Agus Surachman, Aric A. Prather, Eli Puterman, Kevin L. Delucchi, Michael R. Irwin, Andrea Danese, David M. Almeida, Elissa S. Epel
Background Childhood trauma (CT) increases the risk of adult depression. Buffering effects require an understanding of the underlying persistent risk pathways. This study examined whether daily psychological stress processes – how an individual interprets and affectively responds to minor everyday events – mediate the effect of CT on adult depressive symptoms. Methods Middle-aged women (N = 183) reported
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Maternal health around pregnancy and autism risk: a diagnosis-wide, population-based study Psychol. Med. (IF 5.813) Pub Date : 2021-03-26 Arad Kodesh, Stephen Z. Levine, Vahe Khachadourian, Rayees Rahman, Avner Schlessinger, Paul F. O'Reilly, Jakob Grove, Diana Schendel, Joseph D. Buxbaum, Lisa Croen, Abraham Reichenberg, Sven Sandin, Magdalena Janecka
Background Many studies have reported an increased risk of autism spectrum disorder (ASD) associated with some maternal diagnoses in pregnancy. However, such associations have not been studied systematically, accounting for comorbidity between maternal disorders. Therefore our aim was to comprehensively test the associations between maternal diagnoses around pregnancy and ASD risk in offspring. Methods
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Sex differences in neural correlates of common psychopathological symptoms in early adolescence Psychol. Med. (IF 5.813) Pub Date : 2021-03-26 Francesca Biondo, Charlotte Nymberg Thunell, Bing Xu, Congying Chu, Tianye Jia, Alex Ing, Erin Burke Quinlan, Nicole Tay, Tobias Banaschewski, Arun L. W. Bokde, Christian Büchel, Sylvane Desrivières, Herta Flor, Vincent Frouin, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Hervé Lemaitre, Frauke Nees, Dimitri Papadopoulos Orfanos, Luise Poustka, Sabina Millenet, Juliane
Background Sex-related differences in psychopathology are known phenomena, with externalizing and internalizing symptoms typically more common in boys and girls, respectively. However, the neural correlates of these sex-by-psychopathology interactions are underinvestigated, particularly in adolescence. Methods Participants were 14 years of age and part of the IMAGEN study, a large (N = 1526) community-based
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Vitamin D sufficiency attenuates the effect of early social adversity on child antisocial behavior Psychol. Med. (IF 5.813) Pub Date : 2021-03-25 Olivia Choy, Adrian Raine
Background Vitamin D insufficiency and child antisocial behavior are public health concerns. It is unknown whether vitamin D plays a role in antisocial outcomes. This study examines whether higher levels of vitamin D can act as a protective factor against antisocial behavior for children who are exposed to early social adversity. Methods In a community sample of 300 children aged 11–12 years (151 females
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Echoes from the past: adjustment of aging former prisoners of war to the COVID-19 pandemic Psychol. Med. (IF 5.813) Pub Date : 2021-03-18 Karni Ginzburg, Mario Mikulincer, Avi Ohry, Zahava Solomon
Background The aim of this study was to examine whether exposure to previous traumatic events is a risk factor for stress reactions during this pandemic. Capitalizing on a 29-year longitudinal study of Israeli ex-prisoners of war (ex-POWs) and combat veterans, we examined whether captivity is a risk factor for fear of coronavirus disease 2019 (COVID-19) and COVID-19-induced acute stress disorder (COVID-19
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Effects of tDCS during inhibitory control training on performance and PTSD, aggression and anxiety symptoms: a randomized-controlled trial in a military sample Psychol. Med. (IF 5.813) Pub Date : 2021-03-24 Fenne M. Smits, Elbert Geuze, Dennis J. L. G. Schutter, Jack van Honk, Thomas E. Gladwin
Background Post-traumatic stress disorder (PTSD), anxiety, and impulsive aggression are linked to transdiagnostic neurocognitive deficits. This includes impaired inhibitory control over inappropriate responses. Prior studies showed that inhibitory control can be improved by modulating the right inferior frontal gyrus (IFG) with transcranial direct current stimulation (tDCS) in combination with inhibitory
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Understanding different trajectories of mental health across the general population during the COVID-19 pandemic Psychol. Med. (IF 5.813) Pub Date : 2021-03-03 Rob Saunders, Joshua E. J. Buckman, Peter Fonagy, Daisy Fancourt
Background The COVID-19 pandemic and nationally mandated restrictions to control the virus have been associated with increased mental health issues. However, the differential impact of the pandemic and lockdown on groups of individuals, and the personal characteristics associated with poorer outcomes are unknown. Method Data from 21 938 adults in England who participated in a stratified cohort study
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The independent and combined effects of cannabis use and systemic inflammation during the early stages of psychosis: exploring the two-hit hypothesis Psychol. Med. (IF 5.813) Pub Date : 2021-03-19 Fabiana Corsi-Zuelli, Leonardo Marques, Daiane Leite da Roza, Camila Marcelino Loureiro, Rosana Shuhama, Marta Di Forti, Paulo Rossi Menezes, Paulo Louzada-Junior, Cristina Marta Del-Ben
Background Cannabis consumption is a modifiable risk factor associated with psychosis, but not all cannabis users develop psychosis. Animal studies suggest that an antecedent active immune system interacts with subsequent cannabis exposure and moderates the cannabis–psychosis association, supporting the two-hit hypothesis. The clinical investigations are few, and it is unclear if the immune system
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The influence of comorbid depression and overweight status on peripheral inflammation and cortisol levels Psychol. Med. (IF 5.813) Pub Date : 2021-03-18 Anna P. McLaughlin, Naghmeh Nikkheslat, Caitlin Hastings, Maria A. Nettis, Melisa Kose, Courtney Worrell, Zuzanna Zajkowska, Nicole Mariani, Daniela Enache, Giulia Lombardo, Linda Pointon, NIMA Consortium, Philip Cowen, Jonathan Cavanagh, Neil Harrison, Edward Bullmore, Carmine M. Pariante, Valeria Mondelli
Background Depression and overweight are each associated with abnormal immune system activation. We sought to disentangle the extent to which depressive symptoms and overweight status contributed to increased inflammation and abnormal cortisol levels. Methods Participants were recruited through the Wellcome Trust NIMA Consortium. The sample of 216 participants consisted of 69 overweight patients with
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Successful metabolic control in diabetes type 1 depends on individual neuroeconomic and health risk-taking decision endophenotypes: a new target in personalized care Psychol. Med. (IF 5.813) Pub Date : 2021-03-18 Helena Jorge, Isabel C. Duarte, Bárbara R. Correia, Luísa Barros, Ana Paula Relvas, Miguel Castelo-Branco
Background Neurobehavioral decision profiles have often been neglected in chronic diseases despite their direct impact on major public health issues such as treatment adherence. This remains a major concern in diabetes, despite intensive efforts and public awareness initiatives regarding its complications. We hypothesized that high rates of low adherence are related to risk-taking profiles associated
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Using multivariate endophenotypes to identify psychophysiological mechanisms associated with polygenic scores for substance use, schizophrenia, and education attainment Psychol. Med. (IF 5.813) Pub Date : 2021-03-18 Jeremy Harper, Mengzhen Liu, Stephen M. Malone, Matt McGue, William G. Iacono, Scott I. Vrieze
Background To better characterize brain-based mechanisms of polygenic liability for psychopathology and psychological traits, we extended our previous report (Liu et al. Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci. Psychological Medicine, 2017), focused solely on schizophrenia, to test the association between multivariate psychophysiological candidate
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Investigating the effect of national government physical distancing measures on depression and anxiety during the COVID-19 pandemic through meta-analysis and meta-regression Psychol. Med. (IF 5.813) Pub Date : 2021-03-02 João M. Castaldelli-Maia, Megan E. Marziali, Ziyin Lu, Silvia S. Martins
Background COVID-19 physical distancing measures can potentially increase the likelihood of mental disorders. It is unknown whether these measures are associated with depression and anxiety. Objectives To investigate meta-analytic global levels of depression and anxiety during the COVID-19 pandemic and how the implementation of mitigation strategies (i.e. public transportation closures, stay-at-home
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Experimentally imposed circadian misalignment alters the neural response to monetary rewards and response inhibition in healthy adolescents Psychol. Med. (IF 5.813) Pub Date : 2021-03-17 Brant P. Hasler, Adriane M. Soehner, Meredith L. Wallace, Ryan W. Logan, Wambui Ngari, Erika E. Forbes, Daniel J. Buysse, Duncan B. Clark
Background Sleep and circadian timing shifts later during adolescence, conflicting with early school start times, and resulting in circadian misalignment. Although circadian misalignment has been linked to depression, substance use, and altered reward function, a paucity of experimental studies precludes the determination of causality. Here we tested, for the first time, whether experimentally-imposed
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Shared genetic architecture across psychiatric disorders Psychol. Med. (IF 5.813) Pub Date : 2021-03-17 Andrew D. Grotzinger
Psychiatric disorders overlap substantially at the genetic level, with family-based methods long pointing toward transdiagnostic risk pathways. Psychiatric genomics has progressed rapidly in the last decade, shedding light on the biological makeup of cross-disorder risk at multiple levels of analysis. Over a hundred genetic variants have been identified that affect multiple disorders, with many more
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Attentional salience and the neural substrates of response inhibition in borderline personality disorder Psychol. Med. (IF 5.813) Pub Date : 2021-03-16 J. S. Wrege, D. Carcone, A. C. H. Lee, C. Cane, U. E. Lang, S. Borgwardt, M. Walter, A. C. Ruocco
Background Impulsivity is a central symptom of borderline personality disorder (BPD) and its neural basis may be instantiated in a frontoparietal network involved in response inhibition. However, research has yet to determine whether neural activation differences in BPD associated with response inhibition are attributed to attentional saliency, which is subserved by a partially overlapping network
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Comparison of social cognition using an adapted Chinese version of the Reading the Mind in the Eyes Test in drug-naive and regularly medicated individuals with chronic schizophrenia and healthy controls in rural China Psychol. Med. (IF 5.813) Pub Date : 2021-03-16 Fei Deng, Michael R. Phillips, Bing Cai, Gary Yu, Min Qian, Margaux M.R. Grivel, Hanhui Chen, Xinyi Ouyang, Fang Xue, Mingru Zhao, Lawrence S. Kegeles, Ezra S. Susser, Matcheri S. Keshavan, William S. Stone, Lawrence H. Yang
Background Social cognition has not previously been assessed in treatment-naive patients with chronic schizophrenia, in patients over 60 years of age, or in patients with less than 5 years of schooling. Methods We revised a commonly used measure of social cognition, the Reading the Mind in the Eyes Test (RMET), by expanding the instructions, using both self-completion and interviewer-completion versions
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Intrauterine testosterone exposure and depression risk in opposite-sex and same-sex twins, a Danish register study Psychol. Med. (IF 5.813) Pub Date : 2021-03-16 M. Vinberg, M. K. Wium-Andersen, I. K. Wium-Andersen, M. B. Jørgensen, K. Christensen, M. Osler
Background Males have a lower prevalence of depression than females and testosterone may be a contributing factor. A comparison of opposite-sex and same-sex twins can be used indirectly to establish the role of prenatal testosterone exposure and the risk of depression. We therefore aimed to explore differences in depression risk using opposite-sex and same-sex twins. Methods We included 126 087 opposite-sex
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Prevalence of muscle dysmorphia in adolescents: findings from the EveryBODY study Psychol. Med. (IF 5.813) Pub Date : 2021-03-16 Deborah Mitchison, Jonathan Mond, Scott Griffiths, Phillipa Hay, Jason M. Nagata, Kay Bussey, Nora Trompeter, Alexandra Lonergan, Stuart B. Murray
Background We sought to provide the first point prevalence estimates of muscle dysmorphia (MD), a form of body dysmorphic disorder characterized by a preoccupation with perceived insufficient muscularity, in adolescents. Methods Data were taken from a survey of 3618 Australian adolescents (11.172–19.76 years; 49.3% girls). Measures captured demographic characteristics, symptoms of MD and eating disorders
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Exploring the relationship between pain and self-harm thoughts and behaviours in young people using network analysis Psychol. Med. (IF 5.813) Pub Date : 2021-03-15 Verena Hinze, Tamsin Ford, Robin Evans, Bergljot Gjelsvik, Catherine Crane
Background Self-harm thoughts and behaviours (SHTBs) are a serious public health concern in young people. Emerging research suggests that pain may be an important correlate of SHTBs in young people. However, it remains unclear whether this association is driven by the shared association with other correlates of SHTBs. This study used network analysis to delineate the relationship between SHTBs, pain
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Thalamic dysconnectivity in the psychosis risk syndrome and early illness schizophrenia Psychol. Med. (IF 5.813) Pub Date : 2021-03-15 Susanna L. Fryer, Jamie M. Ferri, Brian J. Roach, Rachel L. Loewy, Barbara K. Stuart, Alan Anticevic, Judith M. Ford, Daniel H. Mathalon
Background Schizophrenia (SZ) is associated with thalamic dysconnectivity. Compared to healthy controls (HCs), individuals with SZ have hyperconnectivity with sensory regions, and hypoconnectivity with cerebellar, thalamic, and prefrontal regions. Despite replication of this pattern in chronically ill individuals, less is known about when these abnormalities emerge in the illness course and if they
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Psychosocial and pharmacological treatments for cannabis use disorder and mental health comorbidities: a narrative review Psychol. Med. (IF 5.813) Pub Date : 2021-02-04 Rachel Lees, Lindsey A. Hines, Deepak Cyril D'Souza, George Stothart, Marta Di Forti, Eva Hoch, Tom P. Freeman
Cannabis is the most widely used illicit drug worldwide, and it is estimated that up to 30% of people who use cannabis will develop a cannabis use disorder (CUD). Demand for treatment of CUD is increasing in almost every region of the world and cannabis use is highly comorbid with mental disorders, where sustained use can reduce treatment compliance and increase risk of relapse. In this narrative review
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The predictive power of expressed emotion and its components in relapse of schizophrenia: a meta-analysis and meta-regression Psychol. Med. (IF 5.813) Pub Date : 2021-02-11 Chak Fai Ma, Sherry Kit Wa Chan, Yik Ling Chung, Siu Man Ng, Christy Lai Ming Hui, Yi Nam Suen, Eric Yu Hai Chen
Background Schizophrenia is a longstanding condition and most patients experience multiple relapse in the course of the condition. High expressed emotion (HEE) has been found to be a predictor of relapse. This meta-analysis and meta-regression examined the association of global EE and relapse specifically focusing on timing of relapse and EE domains. Methods Random-effects model was used to pool the
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Demographic and clinical variables associated with response to clozapine in schizophrenia: a systematic review and meta-analysis Psychol. Med. (IF 5.813) Pub Date : 2021-02-19 Kira Griffiths, Edward Millgate, Alice Egerton, James H. MacCabe
Clozapine is the only licensed pharmacotherapy for treatment-resistant schizophrenia. However, response to clozapine is variable. Understanding the demographic and clinical features associated with response to clozapine may be useful for patient stratification for clinical trials or for identifying patients for earlier initiation of clozapine. We systematically reviewed the literature to investigate
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Altered neural activities during response inhibition in adults with addiction: a voxel-wise meta-analysis Psychol. Med. (IF 5.813) Pub Date : 2021-02-22 Zeguo Qiu, Junjing Wang
Background Previous literature has extensively investigated the brain activity during response inhibition in adults with addiction. Inconsistent results including both hyper- and hypo-activities in the fronto-parietal network (FPN) and the ventral attention network (VAN) have been found in adults with addictions, compared with healthy controls (HCs). Methods Voxel-wise meta-analyses of abnormal task-evoked
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Cognitive heterogeneity in first-episode psychosis and its relationship with premorbid developmental adjustment Psychol. Med. (IF 5.813) Pub Date : 2021-03-12 Eric J. Tan, Susan L. Rossell, Kenneth L. Subotnik, Joseph Ventura, Keith H. Nuechterlein
Background Patients with schizophrenia spectrum disorders have been increasingly recognised to form cognitive subgroups with differential levels of impairment. Using cluster analytical techniques, this study sought to identify cognitive clusters in a sample of first-episode psychosis (FEP) patients and examine clinical and developmental differences across the resultant groups. Methods In total, 105
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A comparison of ‘pruning’ during multi-step planning in depressed and healthy individuals Psychol. Med. (IF 5.813) Pub Date : 2021-03-12 Paul Faulkner, Quentin J. M. Huys, Daniel Renz, Neir Eshel, Stephen Pilling, Peter Dayan, Jonathan P. Roiser
Background Real-life decisions are often complex because they involve making sequential choices that constrain future options. We have previously shown that to render such multi-step decisions manageable, people ‘prune’ (i.e. selectively disregard) branches of decision trees that contain negative outcomes. We have theorized that sub-optimal pruning contributes to depression by promoting an oversampling
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