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Multi-platform omics sequencing dissects the atlas of plasma-derived exosomes in rats with or without depression-like behavior after traumatic spinal cord injury Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-03-02 Zhihua Wang, Zhiping Xie, Zhixiong Zhang, Wu Zhou, Boyu Guo, Meihua Li
Exosomes can penetrate the blood-brain barrier for material exchange between the peripheral and central nervous systems. Differences in exosome contents could explain the susceptibility of different individuals to depression-like behavior after traumatic spinal cord injury (TSCI). Hierarchical clustering was used to integrate multiple depression-related behavioral outcomes in sham and TSCI rats and
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Novel genetic loci of inhibitory control in ADHD and healthy children and genetic correlations with ADHD Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-03-01 Tao Pang, Ning Ding, Yilu Zhao, Jingjing Zhao, Li Yang, Suhua Chang
Cumulative evidence has showed the deficits of inhibitory control in patients with attention deficit hyperactivity disorder (ADHD), which is considered as an endophenotype of ADHD. Genetic study of inhibitory control could advance gene discovery and further facilitate the understanding of ADHD genetic basis, but the studies were limited in both the general population and ADHD patients. To reveal genetic
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Genome-wide association studies (GWAS) and post-GWAS analyses of impulsivity: A systematic review Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-03-01 Jiaqi Wang, Ruolei Gu, Xiangzhen Kong, Shenghua Luan, Yu L.L. Luo
Impulsivity is related to a host of mental and behavioral problems. It is a complex construct with many different manifestations, most of which are heritable. The genetic compositions of these impulsivity manifestations, however, remain unclear. A number of genome-wide association studies (GWAS) and post-GWAS analyses have tried to address this issue. We conducted a systematic review of all GWAS and
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Evaluation of cannabimimetic effects of selected minor cannabinoids and Terpenoids in mice Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-27 Jenny L. Wiley, Julie A. Marusich, Bruce E. Blough, Ojas Namjoshi, Marcus Brackeen, Luli R. Akinfiresoye, Teneille D. Walker, Cassandra Prioleau, Daniel G. Barrus, Thomas F. Gamage
The cannabis plant contains several cannabinoids, and many terpenoids that give cannabis its distinctive flavoring and aroma. Δ-Tetrahydrocannabinol (Δ-THC) is the plant's primary psychoactive constituent. Given the abuse liability of Δ-THC, assessment of the psychoactive effects of minor cannabinoids and other plant constituents is important, especially for compounds that may be used medicinally.
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Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysis Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-27 Nahathai Limveeraprajak, Sirapop Nakhawatchana, Apidsada Visukamol, Christsanutth Siripakkaphant, Sirijit Suttajit, Manit Srisurapanont
This systematic review and meta-analysis aimed to assess the efficacy and acceptability of S-adenosyl-L-methionine (SAMe) in treating depression. We conducted a comprehensive search of PubMed, Embase, Cochrane Library, and ClinialTrials.gov from inception to July 3, 2023, identifying randomized controlled trials comparing SAMe with placebo or antidepressants (ADs). We synthesized data on reduced depressive
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Exploring the clinical potentials of zuranolone in managing postpartum depression: A new therapeutic horizon Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-25 Abdulqadir J. Nashwan, Syeda Tayyaba Rehan, Laiba Imran, Samina Ghulam Abbas, Sara Fahim Khan
Postpartum depression (PPD) poses a major threat to maternal mental health and wellbeing while also adversely affecting the mother's relationship with her baby, leading to significant repercussions that may hinder the growth and cognitive development of the child. For decades, antidepressants have been the mainstay of treating PPD; however, recent evidence suggests that antidepressants are not as effective
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The neural substrates responsible for punishment sensitivity association with procrastination: Left putamen connectivity with left middle temporal gyrus Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-20 Zhenzhen Huo, Rong Zhang, Zhiyi Chen, Junye Xu, Ting Xu, Tingyong Feng
Procrastination has adverse consequences across cultural contexts. Behavioral research found a positive correlation between punishment sensitivity and procrastination. However, little is known about the neural substrates underlying the association between them. We employed voxel-based morphometry (VBM) and resting-state functional connectivity (RSFC) methods to address this issue with two independent
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Sex-specific modulation of safety learning in Shank2-deficient mice Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-17 Judith C. Kreutzmann, Evelyn Kahl, Markus Fendt
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impaired perceptual processing and social communication, intellectual disabilities, and repetitive behaviors. Interestingly, while not a core symptom, anxiety disorders frequently co-occur in individuals with ASD and deficits in safety learning have been described in patients with anxiety-related disorders. Because genetic
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Electroconvulsive therapy disrupts functional connectivity between hippocampus and posterior default mode network Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-17 Krzysztof Gbyl, Vytautas Labanaukas, Christoffer Cramer Lundsgaard, André Mathiassen, Adam Ryszczuk, Hartwig Roman Siebner, Egill Rostrup, Kristoffer Madsen, Poul Videbech
The mechanisms underlying memory deficits after electroconvulsive therapy (ECT) remain unclear but altered functional interactions between hippocampus and neocortex may play a role. To test whether ECT reduces functional connectivity between hippocampus and posterior regions of the default mode network (DMN) and to examine whether altered hippocampal-neocortical functional connectivity correlates with
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Aberrant heartbeat-evoked potential in schizophrenia Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-16 Akihiro Koreki, Kamiyu Ogyu, Takahiro Miyazaki, Kazumasa Takenouchi, Karin Matsushita, Shiori Honda, Teruki Koizumi, Mitsumoto Onaya, Hiroyuki Uchida, Masaru Mimura, Shinichiro Nakajima, Yoshihiro Noda
Self-disturbance is considered a core feature underlying the psychopathology of schizophrenia. Interoception has an important role in the development of a sense of self, leading to increased interest in the potential contribution of abnormal interoception to self-disturbances in schizophrenia. Several neuropsychological studies have demonstrated aberrant interoception in schizophrenia. However, cortical
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Atypical dynamic network reconfiguration and genetic mechanisms in patients with major depressive disorder Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-15 Hairong Xiao, Dier Tang, Chuchu Zheng, Zeyu Yang, Wei Zhao, Shuixia Guo
Brain dynamics underlie complex forms of flexible cognition or the ability to shift between different mental modes. However, the precise dynamic reconfiguration based on multi-layer network analysis and the genetic mechanisms of major depressive disorder (MDD) remains unclear. Resting-state functional magnetic resonance imaging (fMRI) data were acquired from the REST-meta-MDD consortium, including
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Dopaminergic dominance in the ventral medial hypothalamus: A pivotal regulator for methamphetamine-induced pathological aggression Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-15 Ludi Zhang, Yufei Sun, Jian Wang, Minglong Zhang, Qingwu Wang, Bing Xie, Feng Yu, Di Wen, Chunling Ma
Methamphetamine (METH) abuse is associated with a spectrum of behavioral consequences, among which heightened aggression presents a significant challenge. However, the causal role of METH's impact in aggression and its target circuit mechanisms remains largely unknown. We established an acute METH exposure-aggression mouse model to investigate the role of ventral tegmental area (VTA) dopaminergic neurons
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Increased grey matter volumes in the temporal lobe and its relationship with cognitive functioning in euthymic patients with bipolar disorder Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-15 D. Porta-Casteràs, M. Vicent-Gil, M. Serra-Blasco, G. Navarra-Ventura, B. Solé, L. Montejo, C. Torrent, A. Martinez-Aran, V. De la Peña-Arteaga, D. Palao, E. Vieta, N. Cardoner, M. Cano
Bipolar disorder (BD) is characterized by episodic mood dysregulation, although a significant portion of patients suffer persistent cognitive impairment during euthymia. Previous magnetic resonance imaging (MRI) research suggests BD patients may have accelerated brain aging, observed as lower grey matter volumes. How these neurostructural alterations are related to the cognitive profile of BD is unclear
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Polygenic risk scores for mood and related disorders and environmental factors: Interaction effects on wellbeing in the UK biobank Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-15 Chiara Fabbri, Cathryn M. Lewis, Alessandro Serretti
Mood disorders have a genetic and environmental component and interactions (GxE) on the risk of psychiatric diseases have been investigated. The same GxE interactions may affect wellbeing measures, which go beyond categorical diagnoses and reflect the health-disease continuum.
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Differentiation between suicide attempt and suicidal ideation in patients with major depressive disorder using cortical functional network Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-13 Sungkean Kim, Kuk-In Jang, Ho Sung Lee, Se-Hoon Shim, Ji Sun Kim
Studies exploring the neurophysiology of suicide are scarce and the neuropathology of related disorders is poorly understood. This study investigated source-level cortical functional networks using resting-state electroencephalography (EEG) in drug-naïve depressed patients with suicide attempt (SA) and suicidal ideation (SI). EEG was recorded in 55 patients with SA and in 54 patients with SI. Particularly
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Can we gain translational insights into the functional roles of cerebral cortex from acortical rodent and naturally acortical zebrafish models? Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-13 Konstantin N. Zabegalov, Fabiano V. Costa, Tatiana O. Kolesnikova, Murilo S. de Abreu, Elena V. Petersen, Konstantin B. Yenkoyan, Allan V. Kalueff
Cerebral cortex is found only in mammals and most prominently present in humans. Various rodent models with fully or partially ablated cortex are commonly used to probe the role of cortex in brain functions and its multiple subcortical projections, including pallium, thalamus and the limbic system. Various rodent models are traditionally used to study the role of cortex in brain functions. A small
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A brief real-time fNIRS-informed neurofeedback training of the prefrontal cortex changes brain activity and connectivity during subsequent working memory challenge Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-13 Xi Yang, Yixu Zeng, Guojuan Jiao, Xianyang Gan, David Linden, Dennis Hernaus, Chaozhe Zhu, Keshuang Li, Dezhong Yao, Shuxia Yao, Yihan Jiang, Benjamin Becker
Working memory (WM) represents a building-block of higher cognitive functions and a wide range of mental disorders are associated with WM impairments. Initial studies have shown that several sessions of functional near-infrared spectroscopy (fNIRS) informed real-time neurofeedback (NF) allow healthy individuals to volitionally increase activity in the dorsolateral prefrontal cortex (DLPFC), a region
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SB-258585 reduces food motivation while blocking 5-HT6 receptors in the non-human primate striatum Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-13 Mathilde Pitoy, Lisa Gauthier, Justine Debatisse, Julie Maulavé, Elise Météreau, Maude Beaudoin, Karine Portier, Véronique Sgambato, Thierry Billard, Luc Zimmer, Sophie Lancelot, Léon Tremblay
The interest in new 5-HT₆ agents stems from their ability to modulate cognition processing, food motivation and anxiety-like behaviors. While these findings come primarily from rodent studies, no studies on primates have been published. Furthermore, our understanding of where and how they act in the brain remains limited. Although the striatum is involved in all of these processes and expresses the
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5-HT1A receptors within the intermediate lateral septum modulate stress vulnerability in male mice Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-13 Jie Zhou, Jiao-Wen Wu, Bai-Lin Song, Yi Jiang, Qiu-Hong Niu, Lai-Fu Li, Ying-Juan Liu
Chronic stress is a major risk factor for psychiatric disorders. However, certain individuals may be at higher risk due to greater stress susceptibility. Elucidating the neurobiology of stress resilience and susceptibility may facilitate the development of novel strategies to prevent and treat stress-related disorders such as depression. Mounting evidence suggests that the serotonin (5-HT) system is
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Decreased short-latency afferent inhibition in individuals with mild cognitive impairment: A TMS-EEG study Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-12 Yu Mimura, Yui Tobari, Shinichiro Nakajima, Mayuko Takano, Masataka Wada, Shiori Honda, Shogyoku Bun, Hajime Tabuchi, Daisuke Ito, Mie Matsui, Hiroyuki Uchida, Masaru Mimura, Yoshihiro Noda
TMS combined with EEG (TMS-EEG) is a tool to characterize the neurophysiological dynamics of the cortex. Among the TMS paradigms, short-latency afferent inhibition (SAI) allows the investigation of inhibitory effects mediated by the cholinergic system. The aim of this study was to compare cholinergic function in the DLPFC between individuals with mild cognitive impairment (MCI) and healthy controls
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Social stress-induced depressive-like symptoms and changes in gut microbial and lipidomic profiles are prevented by pharmacological inhibition of FAAH activity in male rats Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-12 Margherita Barbetti, Leonardo Mancabelli, Federica Vacondio, Giulia Longhi, Francesca Ferlenghi, Martina Viglioli, Francesca Turroni, Luca Carnevali, Marco Mor, Marco Ventura, Andrea Sgoifo, Silvia Rivara
Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity has antidepressant-like effects in preclinical models of stress. In this study, we investigated whether the antidepressant-like effects of FAAH inhibition are associated with corresponding changes in gut microbial and lipidomic profiles, which are emerging as critical components in the pathophysiology of depression. Adult male
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The influence of acute dopamine transporter inhibition on manic-, depressive-like phenotypes, and brain oxidative status in adult zebrafish Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-06 Julia Canzian, João V. Borba, Jaíne Ames, Rossano M. Silva, Cássio M. Resmim, Camilla W. Pretzel, Maria Cecília F. Duarte, Tamiris R. Storck, Khadija A. Mohammed, Isaac A. Adedara, Vania L. Loro, Robert Gerlai, Denis B. Rosemberg
Functional changes in dopamine transporter (DAT) are related to various psychiatric conditions, including bipolar disorder (BD) symptoms. In experimental research, the inhibition of DAT induces behavioral alterations that recapitulate symptoms found in BD patients, including mania and depressive mood. Thus, developing novel animal models that mimic BD-related conditions by pharmacologically modulating
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Alterations in the volume and shape of the basal ganglia and thalamus in schizophrenia with auditory hallucinations Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-05 Marta Perez-Rando, Gracián García-Martí, Maria J. Escarti, Pilar Salgado-Pineda, Peter J. McKenna, Edith Pomarol-Clotet, Eva Grasa, Alba Postiguillo, Iluminada Corripio, Juan Nacher
Different lines of evidence indicate that the structure and physiology of the basal ganglia and the thalamus is disturbed in schizophrenia. However, it is unknown whether the volume and shape of these subcortical structures are affected in schizophrenia with auditory hallucinations (AH), a core positive symptom of the disorder. We took structural MRI from 63 patients with schizophrenia, including 36
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Atypical alpha band microstates produced during eyes-closed resting state EEG in autism Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-02 Sushmit Das, Reza Zomorrodi, Melissa Kirkovski, Aron T. Hill, Peter G. Enticott, Daniel M. Blumberger, Tarek K. Rajji, Pushpal Desarkar
Electroencephalogram (EEG) microstates, which represent quasi-stable patterns of scalp topography, are a promising tool that has the temporal resolution to study atypical spatial and temporal networks in autism spectrum disorder (ASD). While current literature suggests microstates are atypical in ASD, their clinical utility, i.e., relationship with the core behavioural characteristics of ASD, is not
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Therapeutic potential of psychedelics: History, advancements, and unexplored frontiers Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-02 Juliana Marino Maia, Bruna Stefane Alves de Oliveira, Luiz G.S. Branco, Renato Nery Soriano
Psychedelics (serotonergic hallucinogens) are psychoactive substances that can alter perception and mood, and affect cognitive functions. These substances activate 5-HT receptors and may exert therapeutic effects. Some of the disorders for which psychedelic-assisted therapy have been studied include depression, addiction, anxiety and post-traumatic stress disorder. Despite the increasing number of
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The neutrophil-lymphocyte ratio in first-episode medication-naïve patients with schizophrenia: A 12-week longitudinal follow-up study Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-02 Xiaobing Lu, Qianqian Sun, Ling Wu, Meisi Liao, Jing Yao, Meihong Xiu
Inflammation has been related to schizophrenia (SZ). The neutrophil-to-lymphocyte ratio (NLR) is an inexpensive inflammatory marker, however, its potential predictive value in patients with SZ has not been extensively investigated. This study aimed to examine whether NLR could predict the clinical response to antipsychotics in this population. One hundred and ninety-five medication-naïve first-episode
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Effects of the PAM of mGluR2, JNJ-46356479, on brain apoptotic protein levels in a mouse model of schizophrenia Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-01 David Olivares-Berjaga, Albert Martínez-Pinteño, Natalia Rodríguez, Santiago Madero, Llucía Prohens, Irene Martínez-Serrano, Sergi Mas, Constanza Morén, Eduard Parellada, Patricia Gassó
Current treatment for schizophrenia (SZ) ameliorates the positive symptoms, but is inefficient in treating the negative and cognitive symptoms. The SZ glutamatergic dysfunction hypothesis has opened new avenues in the development of novel drugs targeting the glutamate storm, an inducer of progressive neuropathological changes. Positive allosteric modulators of metabotropic glutamate receptor 2 (mGluR2)
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Resolving heterogeneity in dynamics of synchronization stability within the salience network in autism spectrum disorder Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-02-01 Xiaonan Guo, Xia Zhang, Junfeng Liu, Guangjin Zhai, Tao Zhang, Rongjuan Zhou, Huibin Lu, Le Gao
Heterogeneity in resting-state functional connectivity (FC) are one of the characteristics of autism spectrum disorder (ASD). Traditional resting-state FC primarily focuses on linear correlations, ignoring the nonlinear properties involved in synchronization between networks or brain regions. In the present study, the cross-recurrence quantification analysis, a nonlinear method based on dynamical systems
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Brain-derived neurotrophic factor levels across psychiatric disorders: A systemic review and network meta-analysis Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-28 Yazhu Zou, Yuan Zhang, Mengtian Tu, Yu Ye, Mingmei Li, Rongting Ran, Zhili Zou
As an important neurotrophic factor in the central nervous system, Brain-derived Neurotrophic Factor (BDNF) has been implicated in the pathophysiology of psychiatric disorders in many studies. However, its value as a biomarker for the diagnosis and differential diagnosis of mental disorders is still controversial, and its change patterns among different mental disorders have not been compared. We conducted
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The ‘L-factor’: Language as a transdiagnostic dimension in psychopathology Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-26 Wolfram Hinzen, Lena Palaniyappan
Thoughts and moods constituting our mental life incessantly change. When the steady flow of this dynamics diverges in clinical directions, the possible pathways involved are captured through discrete diagnostic labels. Yet a single vulnerable neurocognitive system may be causally involved in psychopathological deviations transdiagnostically. We argue that language viewed as integrating cortical functions
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Ghrelin/GHSR signaling in the lateral septum ameliorates chronic stress-induced depressive-like behaviors Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-24 Leilei Chang, Fengnan Niu, Bin Li
Ghrelin is a gastrointestinal hormone on feeding and metabolism regulation, and acts through its receptor-growth hormone secretagogue receptor (GHSR), which is widely distributed throughout the central nervous system. Recent studies have suggested that ghrelin plays an important role in the regulation of depression, but the underlying mechanisms remain uncertain. Lateral septum (LS) is a critical brain
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Methylphenidate alleviates cognitive dysfunction caused by early manganese exposure: Role of catecholaminergic receptors Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-23 Stephane A. Beaudin, Shanna Howard, Nicholas Santiago, Barbara J. Strupp, Donald R. Smith
Environmental manganese (Mn) exposure is associated with impaired attention and psychomotor functioning, as well as impulsivity/hyperactivity in children and adolescents. We have shown previously that developmental Mn exposure can cause these same dysfunctions in a rat model. Methylphenidate (MPH) lessens impairments in attention, impulse control, and psychomotor function in children, but it is unknown
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Label-based meta-analysis of functional brain dysconnectivity across mood and psychotic disorders Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-22 Stéphanie Grot, Salima Smine, Stéphane Potvin, Maëliss Darcey, Vilena Pavlov, Sarah Genon, Hien Nguyen, Pierre Orban
Background Resting-state functional magnetic resonance imaging (rsfMRI) studies have revealed patterns of functional brain dysconnectivity in psychiatric disorders such as major depression disorder (MDD), bipolar disorder (BD) and schizophrenia (SZ). Although these disorders have been mostly studied in isolation, there is mounting evidence of shared neurobiological alterations across them. Methods
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A search for effective reinforcers in appetitive conditioning for adult zebrafish: Ecologically relevant unconditioned stimuli Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-17 Amira Abozaid, Robert Gerlai
Learning and memory related brain disorders represent a large unmet medical need. Laboratory studies with animals may model brain disorders and facilitate uncovering their mechanisms. The zebrafish has been proposed for such studies. However, numerous factors that influence performance in learning tasks have yet to be understood in zebrafish. One such factor is what motivates zebrafish. Here we introduce
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Increased stress vulnerability in the offspring of socially isolated rats: Behavioural, neurochemical and redox dysfunctions Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-17 Maria Bove, Maria Grazia Morgese, Stefania Dimonte, Vladyslav Sikora, Lisa Pia Agosti, Maria Adelaide Palmieri, Paolo Tucci, Stefania Schiavone, Luigia Trabace
Stressful events during pregnancy impact on the progeny neurodevelopment. However, little is known about preconceptional stress effects. The rat social isolation represents an animal model of chronic stress inducing a variety of dysfunctions. Moreover, social deprivation during adolescence interferes with key neurodevelopmental processes. Here, we investigated the development of behavioural, neurochemical
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The Notch1/Hes1 pathway regulates Neuregulin 1/ErbB4 and participates in microglial activation in rats with VPA-induced autism Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-17 Yanan Deng, Liping Ma, Ziwei Du, Huixin Ma, Yuxi Xia, Liran Ping, Zhaoxing Chen, Yinghua Zhang
The core clinical characteristics of autism, which is a neurodevelopmental disease, involve repetitive behavior and impaired social interactions. Studies have shown that the Notch and Neuregulin1 (NRG1) signaling pathways are abnormally activated in autism, but the mechanism by which these two signaling pathways interact to contribute to the progression of autism has not been determined. Our results
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Disrupted brain structural networks associated with depression and cognitive dysfunction in cerebral small vessel disease with microbleeds Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-20 Haotian Xin, Changhu Liang, Yajie Fu, Mengmeng Feng, Shengpei Wang, Yian Gao, Chaofan Sui, Nan Zhang, Lingfei Guo, Hongwei Wen
Emerging evidence highlights cerebral microbleeds (CMBs) as hallmarks of cerebral small vessel disease (CSVD) underlying depression and cognitive dysfunction. This study aimed to reveal how depression and cognition-related white matter (WM) abnormalities are topologically presented, and the network-level structural disruptions associated with CMBs in CSVD. We used probabilistic diffusion tractography
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Female mice prenatally exposed to valproic acid exhibit complex and prolonged social behavior deficits Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-19 Alexandre Maisterrena, Fabrice de Chaumont, Jean-Emmanuel Longueville, Eric Balado, Elodie Ey, Mohamed Jaber
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized mainly by deficits in social communication and stereotyped and restricted behavior and interests with a male to female bias of 4.2/1. Social behavior in ASD animal models is commonly analyzed in males, and seldomly in females, using the widely implemented three-chambers test procedure. Here, we implemented a novel procedure
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Small molecule NOP agonists reverse locomotor sensitization induced by cocaine in male C57BL/6 mice Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-09 Kabirullah Lutfy, Abdul Hamid, Nurulain T. Zaveri
Orphanin FQ/nociceptin (OFQ/N), the endogenous ligand of the nociceptin opioid receptor (NOP) has been shown to block cocaine-induced locomotor sensitization in mice and rats, and also reverses this phenomenon when injected intracerebroventricularly in animals with an established sensitized response. In the present study, we determined whether small-molecule NOP agonists would recapitulate this effect
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An insight into crosstalk among multiple signalling pathways contributing to the pathophysiology of PTSD and depressive disorders Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-14 Sumadhura Bommaraju, Mrunali D. Dhokne, E.V. Arun, Krishnamoorthy Srinivasan, Shyam Sunder Sharma, Ashok Kumar Datusalia
Post-traumatic stress disorder (PTSD) and depressive disorders represent two significant mental health challenges with substantial global prevalence. These are debilitating conditions characterized by persistent, often comorbid, symptoms that severely impact an individual's quality of life. Both PTSD and depressive disorders are often precipitated by exposure to traumatic events or chronic stress.
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N-acetylcysteine attenuates accumbal core neuronal activity in response to morphine in the reinstatement of morphine CPP in morphine extinguished rats Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-11 Seyedeh-Najmeh Katebi, Anahita Torkaman-Boutorabi, Esmail Riahi, Abbas Haghparast
Numerous studies have suggested that N-acetylcysteine (NAC), has the potential to suppress drug craving in people with substance use disorder and reduce drug-seeking behaviors in animals. The nucleus accumbens (NAc) plays a crucial role in the brain's reward system, with the nucleus accumbens core (NAcore) specifically implicated in compulsive drug seeking and relapse. In this study, we aimed to explore
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Colonic butyrate administration modulates fear memory but not the acute stress response in men: A randomized, triple-blind, placebo-controlled trial Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-08 Boushra Dalile, Annalena Fuchs, Danique La Torre, Bram Vervliet, Lukas Van Oudenhove, Kristin Verbeke
Short-chain fatty acids (SCFAs) are produced in the colon following bacterial fermentation of dietary fiber and are important microbiota-gut-brain messengers. However, their mechanistic role in modulating psychobiological processes that underlie the development of stress- and anxiety-related disorders is scarcely studied in humans. We have previously shown that colonic administration of a SCFA mixture
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The association between plasma thyroxine levels and neurocognitive impairment in early-onset schizophrenia and other psychosis spectrum disorders Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-08 Yesim Saglam, Cagatay Ermis, Denizhan Tanyolac, Ahmet Oz, Serkan Turan, Huseyin Anil Korkmaz, Gul Karacetin
Background/aim Limited studies have delved into the association between thyroid hormones and neurocognition in schizophrenia. We aimed to evaluate the relationship between thyroid hormone levels and neurocognitive functions in patients with schizophrenia and other psychosis spectrum disorders (SSD). Method A total of 135 patients with early-onset SSD were included in the study. The participants underwent
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Pro-inflammatory cytokines in stress-induced depression: Novel insights into mechanisms and promising therapeutic strategies Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2024-01-02 Jun Chang, Tingcan Jiang, Xiaoqian Shan, Mingxing Zhang, Yujiao Li, Xin Qi, Yuhong Bian, Lan Zhao
Stress-mediated depression is one of the common psychiatric disorders with a high prevalence and suicide rate, there is a lack of effective treatment. Accordingly, effective treatments with few adverse effects are urgently needed. Pro-inflammatory cytokines (PICs) may play a key role in stress-mediated depression. Thereupon, both preclinical and clinical studies have found higher levels of IL-1β, TNF-α
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Evaluation of genomic factors and early childhood stimulation on intelligence in children from a Brazilian birth cohort: The primary role of independent factors Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-31 Karen Y. Sánchez-Luquez, Marina Xavier Carpena, Simone M. Karam, Thais Martins-Silva, Fernando C. Barros, Isabel O. de Oliveira, Iná S. Santos, Aluísio J.D. Barros, Alicia Matijasevich, Luciana Tovo-Rodrigues
Background Childhood cognitive abilities are a predictor of health outcomes and adult income potential. Identifying factors associated with childhood intelligence and their interactions is essential in behavioral research. We assessed the impact of genetic variants and early child stimulation (ECS) on child intelligence and examined their possible interaction as potential modifiers of IQ in a population-based
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Association evaluations of oral anticoagulants with dementia risk based on genomic and real-world data Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-26 Junlong Ma, Heng Chen, Chan Zou, Guoping Yang
Background Several observational studies have suggested that oral anticoagulants (OACs) might reduce the risk of dementia in the elderly, but the evidence is inconclusive. And the consistency of this relationship across different OAC classes and dementia subtypes is still uncertain. Methods To comprehensively evaluate this association, we applied Mendelian randomization (MR) combined with pharmacovigilance
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Unraveling the role of Slc10a4 in auditory processing and sensory motor gating: Implications for neuropsychiatric disorders? Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-30 Barbara Ciralli, Thawann Malfatti, Markus M. Hilscher, Richardson N. Leao, Christopher R. Cederroth, Katarina E. Leao, Klas Kullander
Background Psychiatric disorders, such as schizophrenia, are complex and challenging to study, partly due to the lack of suitable animal models. However, the absence of the Slc10a4 gene, which codes for a monoaminergic and cholinergic associated vesicular transporter protein, in knockout mice (Slc10a4−/−), leads to the accumulation of extracellular dopamine. A major challenge for studying schizophrenia
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Transdiagnostic inflammatory and oxidative biomarkers with predictive capacity of self-injurious behavior in impulsive and unstable disorders Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-25 J.M. López-Villatoro, A. De la Torre-Luque, K.S. MacDowell, A. Galvez-Merlin, A. Gómez del Barrio, L. Beato-Fernández, F. Ruiz-Guerrero, P. Mola-Cardenes, F. Polo-Montes, M. León-Velasco, L. Castro-Fuentes, J.C. Leza, J.L. Carrasco, M. Díaz-Marsá
Introduction Alterations in inflammatory processes have previously been reported in impulsive and unstable disorders, as well as in other psychiatric conditions. In order to investigate transdiagnostic biomarkers associated with various phenotypic features of these disorders, this study is designed to identify biomarkers of inflammatory and oxidative endophenotypes related to autolytic behavior. Methods
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Role of the immune-kynurenine pathway in treatment-resistant schizophrenia Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-24 Wenjin Chen, Yichang Tian, Mengzhuang Gou, Leilei Wang, Jinghui Tong, Yanfang Zhou, Wei Feng, Yanli Li, Song Chen, Yongchang Liu, Zhiren Wang, Shujuan Pan, Ping Zhang, Junchao Huang, Xiaokui Yang, Chiang-Shan R. Li, Li Tian, L. Elliot Hong, Yunlong Tan
Background The immune-inflammatory response system (IRS) and kynurenine pathway (KP) have been implicated in the pathophysiology of schizophrenia. Studies have shown inflammation-related effects on KP metabolism in patients with schizophrenia. This study investigated the relationship between KP metabolites, IRS, and the compensatory immune-regulatory reflex system (CIRS) in patients with treatment-resistant
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Identification of novel rare variants for anxiety: an exome-wide association study in the UK Biobank Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-26 Chuyu Pan, Shiqiang Cheng, Li Liu, Yujing Chen, Peilin Meng, Xuena Yang, Chun'e Li, Jingxi Zhang, Zhen Zhang, Huijie Zhang, Bolun Cheng, Yan Wen, Yumeng Jia, Feng Zhang
Background Rare variants are believed to play a substantial role in the genetic architecture of mental disorders, particularly in coding regions. However, limited evidence supports the impact of rare variants on anxiety. Methods Using whole-exome sequencing data from 200,643 participants in the UK Biobank, we investigated the contribution of rare variants to anxiety. Firstly, we computed genetic risk
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Measuring pain intensity in older adults. Can the visual analogue scale and the numeric rating scale be used interchangeably? Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-22 Maria Torheim Bjelkarøy, Jūratė Šaltytė Benth, Tone Breines Simonsen, Tahreem Ghazal Siddiqui, Socheat Cheng, Espen Saxhaug Kristoffersen, Christofer Lundqvist
Objectives Visual analogue scale (VAS) and numeric rating scale (NRS) are two commonly used instruments for measuring pain intensity. Both instruments are validated for use in both clinical and research settings, and share a range of similar aspects. Some studies have shown that the two instruments may be used interchangeably, but the results are conflicting. In this study we assessed whether the VAS
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The role of SIRT3 in mediating the cognitive deficits and neuroinflammatory changes associated with a developmental animal model of schizophrenia Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-18 Keke Hao, Fashuai Chen, Shilin Xu, Ying Xiong, Rui Xu, Huan Huang, Chang Shu, Huiling Wang, Gaohua Wang, Gavin P. Reynolds
The neuroinflammatory state may contribute to the pathogenesis of many mental disorders including schizophrenia. Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor for activation of proteins involved in mitochondria quality control, such as Sirtuin3 (SIRT3). Our previous study has found that NAD+ supplement could rescue early life stress (ELS)-induced neuroinflammation and down-regulation
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Aggregation of Disrupted in Schizophrenia 1 arises from a central region of the protein Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-21 Beti Zaharija, Nicholas J. Bradshaw
An emerging approach to studying major mental illness is through proteostasis, with the identification of several proteins that form insoluble aggregates in the brains of patients. One of these is Disrupted in Schizophrenia 1 (DISC1), a neurodevelopmentally-important scaffold protein, and product of a classic schizophrenia risk gene. DISC1 aggregates have been detected in post mortem brain tissue from
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Cannabinoid CB2 receptors and hypersensitivity to methamphetamine: Vulnerability to schizophrenia Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-20 Ana Canseco-Alba, Koichi Tabata, Yukihiko Momoki, Taharima Tabassum, Yasue Horiuchi, Tadao Arinami, Emmanuel S. Onaivi, Hiroki Ishiguro
The human cannabinoid receptor 2 (CB2R) gene CNR2 has been associated with schizophrenia development. Inbred mice treated with the CB2R inverse agonist AM630 and challenged with methamphetamine (MAP) showed reduced prepulse inhibition (%PPI) response and locomotor hyperactivity, both behavioral measures in rodents that correlate with psychosis. Mice lacking CB2R on striatal dopaminergic neurons exhibit
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Acute ketamine induces neuronal hyperexcitability and deficits in prepulse inhibition by upregulating IL-6 Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-14 Yayan Luo, Yang Yu, Hongbo He, Ni Fan
Acute ketamine administration results in psychotic symptoms similar to those observed in schizophrenia and is regarded as a pharmacological model of schizophrenia. Accumulating evidence suggests that patients with schizophrenia show increased IL-6 levels in the blood and cerebrospinal fluid and that IL-6 levels are associated with the severity of psychotic symptoms. In the present study, we found that
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Behavioural traits related with resilience or vulnerability to the development of cocaine-induced conditioned place preference after exposure of female mice to vicarious social defeat Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-13 Maria Ángeles Martínez-Caballero, Claudia Calpe-López, Maria Pilar García-Pardo, Maria Carmen Arenas, Jose Enrique de la Rubia Ortí, Raquel Bayona-Babiloni, Maria Asunción Aguilar
Exposure to stress induced by intermittent repeated social defeat (IRSD) increases vulnerability to the development of cocaine-induced conditioned place preference (CPP) among male mice; however, some defeated mice are resilient to these effects of stress. In the present study we evaluated the effects of vicarious IRSD (VIRSD) in female mice and explored behavioural traits that are potentially predictive
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The effect of neuroendocrine abnormalities on the risk of psychiatric readmission after hospitalization for bipolar disorder: A retrospective study Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-17 Fangyi Deng, Xiaoxuan Fan, Jiwu Liao, Rui Tang, Xizhe Sun, Jingjing Lin, Guimei Zhang, Jiyang Pan
Background The correlation between the endocrine system and bipolar disorder(BD) has been well recognized, yet the influence of neuroendocrine hormones on readmission risk post-hospitalization for BD remains largely unexplored. This retrospective cohort study was to scrutinize the impact of neuroendocrine functionality on the readmission of patients with BD post-hospitalization for mental disorders
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Postweaning intermittent sleep deprivation enhances defensive attack in adult female mice via the microbiota-gut-brain axis Prog. Neuropsychopharmacol. Biol. Psychiatry (IF 5.6) Pub Date : 2023-12-15 Boya Huang, Shihao Liang, Xinrui Li, Ziyu Xie, Rui Yang, Binhuang Sun, Jiping Xue, Bingyu Li, Sheng Wang, Haishui Shi, Yun Shi