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Non-invasive Assessment of Radiation-Induced Renal Injury in Mice Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-19 Anis Ahmad; Junwei Shi; Saba Ansari; Jumana Afaghani; Judith Molina; Alan Pollack; Sandra Merscher; Youssef H. Zeidan; Alessia Fornoni; Brian Marples
Abstract Purpose The kidney is a radiosensitive late-responding normal tissue. Injury is characterized by radiation nephropathy and decline of glomerular filtration rate (GFR). The current study aimed to compare two rapid and cost-effective methodologies of assessing GFR against more conventional biomarker measurements. Methods C57BL/6 mice were treated with bilateral focal X-irradiation (1x14Gy or
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Hematopoietic protection and mechanisms of ferrostatin-1 on hematopoietic acute radiation syndrome of mice Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-19 Xiaohong Zhang; Mengxin Tian; Xin Li; Chunyan Zheng; Ailian Wang; Jundong Feng; Xiaodan Hu; Shuquan Chang; Haiqian Zhang
Abstract Purpose Baicalein (an anti-ferroptosis drug) was recently reported to synergistically improve the survival rate of mice following a high dose of total body irradiation with anti-apoptosis and anti-necroptosis drugs. At the same time, our group has demonstrated that ferrostatin-1, a ferroptosis inhibitor, improves the survival rate of a mouse model of hematopoietic acute radiation syndrome
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Posterior subcapsular cataracts are a late effect after acute exposure to 0.5 Gy ionizing radiation in mice Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-19 Sarah Kunze; Alexander Cecil; Cornelia Prehn; Gabriele Möller; Andreas Ohlmann; Gerhild Wildner; Stephan Thurau; Kristian Unger; Ute Rößler; Sabine M. Hölter; Soile Tapio; Florian Wagner; Andreas Beyerlein; Fabian Theis; Horst Zitzelsberger; Ulrike Kulka; Jerzy Adamski; Jochen Graw; Claudia Dalke
Abstract Purpose The long-term effect of low and moderate doses of ionizing radiation on the lens is still a matter of debate and needs to be evaluated in more detail. Material and Methods We conducted a detailed histological analysis of eyes from B6C3F1 mice cohorts after acute gamma irradiation (60Co source; 0.063 Gy/min) at young adult age of 10 weeks with doses of 0.063, 0.125 and 0.5 Gy. Sham
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Research progress on radioprotective effects of bee products Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-19 Xin Zhang; Huali Song; Xiangyou Tang; Shuang Wang; Juan Li; Yuhui Hao
Abstract Radiation exposure is an on going and serious threat in military and public health concern. There is an unmet need for effective preventative or mitigative treatments against radiation-induced injuries. The handful of Food and Drug Administration in the US approved radiation protection agents cannot be widely used due to their side effects. Some natural non-toxic compounds such as bee products
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Antioxidant Activity of Curcumin Protects against the Radiation-Induced Micronuclei Formation in Cultured Human Peripheral Blood Lymphocytes Exposed to Various Doses of γ-Radiation Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-19 Ganesh Chandra Jagetia
ABSTRACT Purpose Ionizing radiations trigger the formation of free radicals that damage DNA and cause cell death. DNA damage may be simply evaluated by micronucleus assay and the pharmacophores that impede free radicals could effectively reduce the DNA damage initiated by irradiation. Therefore, it was desired to determine the capacity of curcumin to alleviate micronuclei formation in human peripheral
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Down-regulation of Autophagy-Associated Protein Increased Acquired Radio-Resistance Bladder Cancer Cells Sensitivity to Taxol Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-14 Xiangli Ma; Guangmin Mao; Rulve Chang; Fang Wang; Xiangyan Zhang; Zhaolu Kong
Abstract Background As a bladder-preserving therapy, radiation therapy (RT) has been widely used in the treatment of bladder cancer (BCa) and made great progress in the past few decades. However, some BCa patients have low radiotherapy responsiveness and local recurrence rate after radiotherapy could reach 50%. Acquired radio-resistance (ARR) is one of the important reasons for the failure of RT. Unfortunately
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Translational approaches for radiation risk assessment Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Isaf Al-Nabulsi; Daniela Stricklin
(2021). Translational approaches for radiation risk assessment. International Journal of Radiation Biology: Vol. 97, Translational Approaches for Radiation Risk Assessment, pp. 1-1.
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Chaetocin induced chromatin condensation: effect on DNA repair signalling and survival Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-11 A. Sak; K. Bannik; M. Groneberg; M. Stuschke
Abstract Purpose The aim of the present study was to evaluate the effect of the histone lysine-methyltransferase (HKMT) inhibitor chaetocin on chromatin structure and its effect on ionising radiation (IR) induced DNA damage response. Methods Concentration and time dependent effects of chaetocin on chromatin clustering, its reversibility and association with cell cycle and chromatin markers were analysed
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Investigation of Radon Sources, Health Hazard and Risks assessment for children using analytical and geospatial techniques in District Bannu (Pakistan) Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-11 Huma Shakoor; Noor Jehan; Sardar Khan; Ullah Nimat
Abstract Purpose Radon (Rn) is a radioactive, odorless, and colorless gas which has a half-life of 3.83 days. One of the main sources of Rn which is directly consumed by the population is Groundwater (Tube well, Bore well, Hand pump). Radon gas is found naturally in rock, soil and water and can be considered as main health risk factor in terms of lung cancer, stomach diseases, leukemia and childhood
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Environmental radiobiology of amphibians – knowledge gaps to be filled using cell lines Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-11 Nguyen T. K. Vo
Abstract Purpose Amphibians are facing an unprecedented level of population declines worldwide. The causes run the gamut from habit loss, succumbing to opportunistic pathogen infections to vulnerability to toxic pollutants and ultraviolet (UV)-B radiation exposure. Anthropogenic activities including Chernobyl and Fukushima nuclear disasters and radioactive waste leakage into the environment raise the
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Radiation Induces Stress and Transgenerational Impacts in the Cricket, Acheta domesticus Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-11 Xiaobing Li; C. D. Rollo
Abstract Purpose Radiation exposure of crickets during their 4th juvenile molt inflicted ionizing radiation damage and altered growth rate, adult size at sexual maturity. High levels of ionizing radiation also impacted the subsequent generation, likely via heritable epigenetic mechanisms. Using radiation as a proxy for external stress, we aim to to understand transgenerational impacts of stress on
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Synthesis and characterization of gadolinium-decorated [60]fullerene for tumor imaging and radiation sensitization Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-11 Byung-Kyu Kim; Yuri Mackeyev; Subhiksha Raghuram; Sang Hyun Cho; Sunil Krishnan
Abstract Purpose: The excellent contrast of high atomic number (Z) elements compared to soft tissues has advanced their use as contrast agents for computed tomographic imaging and as potential radiation sensitizers. We evaluated whether gadolinium (Gd) could serve as such a theranostic agent for high-resolution magnetic resonance imaging (MRI) due to its paramagnetic properties and radiosensitization
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Cytoproliferative effect of low dose alpha radiation in human lung cancer cells is associated with connexin 43, caveolin-1, and survivin pathway Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-08 Vasumathy Rajan; Badri Narain Pandey
Abstract Purpose High LET including alpha radiation-based approaches have been proved as a promising mode for cancer therapy owing to their biophysical and radiobiological advantages compared to photon beams. Studies pertaining to effect of α-radiation on cancer cells are limited to cytotoxic high doses. Materials and methods In this study, human lung adenocarcinoma (A549) cells were α-irradiated using
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A review of studies of childhood cancer and natural background radiation Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-04 Gerald M Kendall; Mark P Little; Richard Wakeford
Abstract Purpose The projected existence and magnitude of carcinogenic effects of ionising radiation at low doses and low dose rates is perhaps the most important issue in radiation protection today. Studies of childhood cancer and natural background radiation have the potential to throw direct light on this question, into a dose range below a few tens of mSv. This paper describes the studies that
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Small is beautiful: low activity alpha and gamma sources for small-scale radiation protection research experiments Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-04 Magdalena Płódowska; Milagrosa Lopez-Riego; Pamela Akuwudike; Daniel Sobota; Mateusz Filipek; Mariusz Kłosowski; Urszula Kaźmierczak; Beata Brzozowska; Agnieszka Baliga; Halina Lisowska; Janusz Braziewicz; Paweł Olko; Lovisa Lundholm; Andrzej Wojcik
Abstract Purpose Uncertainties regarding the magnitude of health effects following exposure to low doses of ionising radiation remain a matter of concern both for professionals and for the public. There is consensus within the international radiation research community that more research is required on biological effects of radiation doses below 100 mGy applied at low dose rates. Moreover, there is
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Summary of Radiation Research Society Online 66th Annual Meeting, Symposium on “Epidemiology: Updates on epidemiological low dose studies”, including Discussion Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2021-01-04 Cato M Milder; Gerald M Kendall; Aryana Arsham; Helmut Schöllnberger; Richard Wakeford; Harry M Cullings; Mark P Little
Abstract N/A
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Role of miRNAs in regulating responses to radiotherapy in human breast cancer Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-23 Zhi Xiong Chong; Swee Keong Yeap; Wan Yong Ho
Abstract Breast cancer is the most common type of cancer that affects females globally. Radiotherapy is a standard treatment option for breast cancer, where one of its most significant limitations is radioresistance development. MicroRNAs (miRNAs) are small, non-protein-coding RNAs that have been widely studied for their roles as disease biomarkers. To date, several in vitro, in vivo, and clinical
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Chronic exposure to low doses of ionizing radiation impacts the processing of glycoprotein N-linked glycans in Medaka (Oryzias latipes) Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-21 Yeni Natalia C. Perez-Gelvez; Shem Unger; Simone Kurz; Katelyn Rosenbalm; William Matthew Wright; Olin E. Rhodes Jr.; Michael Tiemeyer; Carl W. Bergmann
Abstract Purpose Ionizing radiation is found naturally in the environment; we receive low doses regularly from space, soil, rocks, water, air, and vegetation. While a low dose of IR may have beneficial applications, especially in medicine, it also has the potential to cause detrimental long-term health effects. Alterations in phenotypes and biomolecules after exposure to high levels of IR are well
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Reply to: Regarding: Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-17 Gustavo Viani Arruda; Raissa Renata dos Santos Weber; Alexandre Colello Bruno; Juliana Fernandes Pavoni
Reply to: Regarding: 'The risk of induced cancer and ischemic heart disease following low dose lung irradiation for COVID-19: estimation based on a virtual case'. International Journal of Radiation Biology. Accepted .
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Radiation-induced bystander effects may contribute to radiation-induced cognitive impairment Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-17 Xuejiao Yang; Linlin Ma; Zhujing Ye; Wenyu Shi; Liyuan Zhang; Jingdong Wang; Hongying Yang
Abstract Purpose Despite being a major treatment modality for brain cancer due to its efficiency in achieving cancer control, radiotherapy has long been known to cause long-term side effects, including radiation-induced cognitive impairment (RICI). Neurogenesis inhibition due to radiation-induced damage in neural stem cells (NSCs) has been demonstrated to be an important mechanism underlying RICI.
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Isolation of the effects of alpha-related components from total effects of radium at low doses Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-17 Chandula Fernando; Soo Hyun Byun; Xiaopei Shi; Colin B. Seymour; Carmel E. Mothersill
Abstract Purpose Radium is the most common source of alpha radiation exposure to humans and non-human species in the environment but the dosimetry is complicated by the decay chain which involves gamma exposure due to radon daughters. This paper seeks to determine the separate contributions of alpha and gamma doses to the total dose and total direct and non-targeted effect in a fish and a human cell
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First radiobiological characterization of the McCune-Albright syndrome: influence of the ATM protein and effect of statins + bisphosphonates treatment Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Jean-Thomas Bachelet; Adeline Granzotto; Mélanie Ferlazzo; Laurène Sonzogni; Elise Berthel; Clément Devic; Nicolas Foray
Abstract Purpose. Mac-Cune Albright syndrome (MAS) is a rare autosomal dominant osteo-hormonal disorder. MAS is characterized by a severe form of polyostotic fibrous dysplasia, “café-au-lait” pigmentation of the skin, and multiple endocrinopathies. MAS was shown to be caused by mosaic missense somatic mutations in the GNAS gene coding for the alpha-subunit of the stimulatory G-protein. MAS is also
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Low-dose radiotherapy (LD-RT) for COVID-19-induced pneumopathy: a worth considering approach Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Fereshteh Koosha; Atieh Pourbagheri-Sigaroodi; Mohhsen Bakhshandeh; Davood Bashash
Abstract Purpose It seems that 2020 would be always remembered by the name of novel coronavirus (designated as SARS-CoV-2), which exerted its deteriorating effects on the health care, economy, education, and political relationships. In August 2020 more than eight hundred thousand patients lost their lives due to acute respiratory syndrome. In the limited list of therapeutic approaches, the effectiveness
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Genetic improvement of pyrethrum (Tanacetum cinerariifolium Sch. Bip.) through gamma radiation and selection of high yield stable mutants through seven post-radiation generations Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Raj Kishori Lal; Chandan Singh Chanotiya; Pankhuri Gupta; Anand Mishra; M. M. Gupta
Abstract Purpose To increase the size of the flowers for easy plucking, flower yield, pyrethrins content (%), and elite mutant selection in pyrethrum. Materials and methods To increase pyrethrum production and acclimatize in north Indian plain condition, a genetic improvement program was undertaken to widen the range of variations for size and yield of flowers and pyrethrins content (%) in pyrethrum
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Radioprotective effect of melatonin against radiotherapy-induced cerebral cortex and cerebellum damage in rat Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Serhat Aras; Mustafa Efendioğlu; Aini Wulamujiang; Sıdıka Şeyma Özkanlı; Mevlüt Sait Keleş; İhsan Oğuz Tanzer
Abstract Purpose The present study aims to investigate the radioprotective effect of melatonin (MEL) against early period brain damage caused by different dose rate beams in the experimental rat model. Materials and methods Forty-eight Sprague Dawley rats were randomly divided into six groups; the control, only melatonin, low dose rate-radiotherapy (LDR-RT), high dose rate-radiotherapy (HDR-RT) groups
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Impact of paternal transmission of gamma radiation on reproduction, oogenesis and spermatogenesis of the housefly, Musca domestica L. (Diptera: Muscidae) Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Ahmed I. Hasaballah
Abstract Purpose This study aimed to investigate the impact of gamma radiation of Musca domestica males (resulted from irradiated pupae) crossed with unirradiated females on fecundity, egg-hatchability, adult emergence, sex ratio, sterility, in addition to reproductive development at the level of oogenesis and spermatogenesis compared to unirradiated group. Material and Methods The housefly, M. domestica
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Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Dusan Vukmirovic; Nguyen T. K. Vo; Colin Seymour; Dave Rollo; Carmel Mothersill
Abstract Purpose The main goal of the research was to determine whether commercially available common dietary phytochemical supplements (curcumin, andrographolide, and d-limonene) have radiomodulatory effects on p53-competent human colonic epithelial cells. Methods Clonogenic survival assays were used to characterize effects of the phytochemicals on cultured colonic epithelial cells (HCT116 p53+/+)
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Regarding: “The risk of induced cancer and ischemic heart disease following low dose lung irradiation for COVID-19: estimation based on a virtual case” Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Joseph J Bevelacqua; James S. Welsh; SMJ Mortazavi
Regarding: “The risk of induced cancer and ischemic heart disease following low dose lung irradiation for COVID-19: estimation based on a virtual case”. International Journal of Radiation Biology. Accepted 8 December 2020.
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Dynamics of Caspase Activation upon UV induced Genotoxic Injury Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Felicitas Mayer; Ivonne Kemnitz; Guido Fitze; Michael G Haase
Abstract Purpose Caspases are common mediators of cell death. Evasion of cell death including apoptosis are considered to be hallmarks of cancer. A deeper understanding of the apoptotic cascade may aid improving cancer therapies. Our aim was to characterize the progression of cell death following UV-induced genotoxic injury in a defined cell culture model. Materials and Methods Hela cells were UV-irradiated
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The different doses of radiation therapy-induced damage to the ovarian environment in rats Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Gozde Ozge Onder; Esra Balcioglu; Munevver Baran; Ayse Ceyhan; Ozge Cengiz; Pinar Alisan Suna; Oguz Galip Yıldız; Arzu Yay
Abstract Purpose The sequelae of premature loss of ovarian function can undoubtedly have undesirable effects for a woman although radiotherapy is one of the most relevant treatment modalities for various types of malignancies. The aim of this study was to determine the effect of different doses of radiation on ovarian folliculogenesis, inflammation, and apoptotic markers. Materials and Methods For
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Radiobiological comparison of flattening filter (FF) and flattening filter free (FFF) beam in rat laryngeal tissue Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-15 Serhat Aras; İhsan Oğuz Tanzer; Neslihan Sayir; Mevlüt Sait Keleş; Fatma Betül Özgeriş
Abstract Purpose The purpose of this study is to investigate the radioprotective effect of melatonin by analyzing histopathological changes and serum biochemical levels on experimental rat models exposed to flattening filter (FF) and flattening filter free (FFF) beam. Materials and methods Forty-eight healthy adult Sprague Dawley rats were randomly divided into six groups. The control (Group 1) was
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Effects of Low Dose and Low Dose Rate Low Linear Energy Transfer Radiation on Animals – Review of Recent Studies Relevant for Carcinogenesis Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-08 Tatjana Paunesku; Aleksandra Stevanović; Jelena Popović; Gayle E Woloschak
Abstract Purpose Carcinogenic effects of radiation are often assumed to be universally understood, more often than, for example, carcinogenic effects of many different chemicals. This in turn leads to an assumption that any dose of radiation, delivered at any dose rate, poses a serious health challenge. However, ionizing radiation is part of our environment and all life on Earth’s crust is exposed
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Experimental Study of Potential Adverse Effects on the Auditory System of Rabbits Exposed to Short-Term GSM-1800 Radiation Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-02 Antigoni E. Kaprana; Ioannis O. Vardiambasis; Theodoros N. Kapetanakis; Melina P. Ioannidou; Christos D. Nikolopoulos; Grigorios E. Lyronis
Abstract Purpose The effects of the electromagnetic (EM) radiation emitted by a mobile phone on the central auditory system of rabbits are investigated in this paper. Auditory brainstem response (ABR) measurements were performed before and after short-term exposure to EM radiation. Materials and Methods Excitation was provided by a GSM-1800 emitter placed in contact with the (randomly selected) ear
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Dose-dependent long-term effects of a single radiation event on behaviour and glial cells Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-02 Marie-Claire Ung; Lillian Garrett; Claudia Dalke; Valentin Leitner; Daniel Dragosa; Daniela Hladik; Frauke Neff; Florian Wagner; Horst Zitzelsberger; Gregor Miller; Martin Hrabě de Angelis; Ute Rößler; Daniela Vogt Weisenhorn; Wolfgang Wurst; Jochen Graw; Sabine M. Hölter
Abstract Purpose The increasing use of low-dose ionizing radiation in medicine requires a systematic study of its long-term effects on the brain, behaviour and its possible association with neurodegenerative disease vulnerability. Therefore, we analysed the long-term effects of a single low-dose irradiation exposure at 10 weeks of age compared to medium and higher doses on locomotor, emotion-related
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Induced mutation breeding for qualitative and quantitative traits and varietal development in medicinal and aromatic crops at CSIR-CIMAP, Lucknow (India): past and recent accomplishment Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-02 Raj K. Lal; Chandan S. Chanotiya; Pankhuri Gupta
Abstract Purpose The nature and kind of some successful mutations achieved through gamma radiation at CSIR-CIMAP, Lucknow are reviewed and described in this article. Medicinal and aromatic crops (MACs) came under the mutation-breeding program very late – perhaps during the 1980s in India. Nevertheless, successes have been glaring and unique too. The plant breeders of the Institute concerted attempts
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Tumor treating fields (TTF) treatment enhances radiation-induced apoptosis in pancreatic cancer cells Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-02 Yunhui Jo; Geon Oh; Yongha Gi; Heehun Sung; Eun Bin Joo; Suk Lee; Myonggeun Yoon
Abstract Purpose Tumor treating fields (TTF) therapy is a noninvasive method that uses alternating electric fields to treat various types of cancer. This study demonstrates the combined effect of TTF and radiotherapy (RT) in vitro on pancreatic cancer, which is known to be difficult to treat. Materials and methods In CFPAC-I and HPAF-II pancreatic cancer cell lines, the combined in vitro effect of
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Response of breast cancer carcinoma spheroids to combination therapy with radiation and DNA-PK inhibitor: growth arrest without a change in α/β ratio Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-09 Jing Yu; Ryan Lu; Jessie R. Nedrow; George Sgouros
Abstract Purpose Agents that increase tumor radiosensitivity are of interest in improving outcomes in radiotherapy (XRT). DNA-PK inhibitors radiosensitize and alter cell adhesion proteins. We investigated combination radiation and a DNA-PK inhibitor in monolayers vs spheroids. Materials and methods Using HER2 positive mammary carcinoma cells, we investigated the impact of NU7441, a DNA-PK inhibitor
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Clinical efficacy of external beam radiotherapy complementing incomplete transarterial chemoembolization for hepatocellular carcinoma Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-10-14 Sunmin Park; Won Sup Yoon; Mi Hee Jang; Chai Hong Rim
Abstract Purpose External beam radiotherapy (EBRT) has been commonly applied as salvage or a combination locoregional modality after transarterial chemoembolization (TACE) for hepatocellular carcinomas (HCCs). This study reports oncologic outcomes and feasibility after application of the two modalities in our center. Methods Forty consecutive patients who underwent EBRT due to incomplete responses
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Taurine abates the liver damage induced by γ-irradiation in rats through anti-inflammatory and anti-apoptotic pathways Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-10-06 Engy F. El-Maraghi; Kamal I. Abdel-Fattah; Saeed M. Soliman; Wael M. El-Sayed
Abstract Background Radiotherapy is the most common regimen for treating human cancers; however, ionizing radiation (IR) has hazardous effects on metabolically active organs such as the liver. Aim This study aimed to investigate the possible protective (prophylactic and therapeutic) action of taurine against liver damage induced by gamma irradiation at different time intervals as well as the mechanisms
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Gut microbiota response to ionizing radiation and its modulation by HDAC inhibitor TSA Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-10-16 Noopur Gupta; Anup Kainthola; Manisha Tiwari; Paban K. Agrawala
Abstract Aim Trichostatin A (TSA) has been shown to mitigate whole body γ-radiation-induced morbidity and mortality. The current study aimed at studying the effects of TSA post-irradiation treatment on gut-microbiota, especially the translocation of the microbes from the intestine to other organs in C57 Bl/6 mice model. Materials and methods On 1st, 3rd 5th 7th 9th 12th and 14th days after various
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Improving the accuracy of dose estimates from automatically scored dicentric chromosomes by accounting for chromosome number Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-10-16 David Endesfelder; Ulrike Kulka; Jochen Einbeck; Ursula Oestreicher
Abstract Purpose The traditional workflow for biological dosimetry based on manual scoring of dicentric chromosomes is very time consuming. Especially for large-scale scenarios or for low-dose exposures, high cell numbers have to be analyzed, requiring alternative scoring strategies. Semi-automatic scoring of dicentric chromosomes provides an opportunity to speed up the standard workflow of biological
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Enhanced response of radioresistant carcinoma cell line to heterogeneous dose distribution of grid; the role of high-dose bystander effect Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-12 Fatemeh Pakniyat; Hassan Ali Nedaie; Hossein Mozdarani; Aziz Mahmoudzadeh; Mahdieh Salimi; Robert J. Griffin; Somayeh Gholami
Abstract Purpose The classical dogma that restricted the radiation effect to the directly irradiated cells has been challenged by the bystander effect. This off-target phenomenon which was manifested in adjacent cells via signaling of fully exposed cells might be involved in high-dose Grid therapy as well. Here, an in-vitro study was performed to examine the possible extent of carcinoma cells response
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Passage of uranium through human cerebral microvascular endothelial cells: influence of time exposure in mono- and co-culture in vitro models Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-10-06 C. Gloaguen; A. F. Raimundo; C. Elie; A. Schmitt; M. Floriani; S. Favard; D. Monneret; F. Imbert-Bismut; N. Weiss; M. A. Deli; K. Tack; P. Lestaevel; M. A. Benadjaoud; A. Legendre
Abstract Purpose Depleted uranium (DU) has several civilian and military applications. The effects of this emerging environmental pollutant on human health raise some concerns. Previous experimental studies have shown that uranium (U) exposure can disturb the central nervous system. A small quantity of U reaches the brain via the blood, but the effects on the blood-brain barrier (BBB) remain unclear
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Overall survival in mCPRC patients treated with Radium-223 in association with bone health agents: a national multicenter study Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-03 Viviana Frantellizzi; Fabio Monari; Manlio Mascia; Renato Costa; Giuseppe Rubini; Angela Spanu; Alessio Farcomeni; Elisa Lodi Rizzini; Luca Cindolo; Maria Licari; Valentina Lavelli; Susanna Nuvoli; Maria Ricci; Valeria Dionisi; Anna Giulia Nappi; Giuseppe De Vincentis
Abstract Purpose Radium-223 has demonstrated efficacy in improving overall survival (OS) and in delaying symptomatic skeletal-related events (SREs). Bone Health Agents (BHA), i.e. RANK ligand inhibitor (Denosumab) and bisphosphonate such as zoledronic acid, are indicated to prevent SREs without a clear survival benefit. SREs on patient health have a high impact and it is, therefore, important to consider
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Increasing the efficiency of the retinoblastoma brachytherapy protocol with ultrasonic hyperthermia and gold nanoparticles: a rabbit model Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-09 Somayeh Moradi; Manijhe Mokhtari-Dizaji; Fariba Ghassemi; Shahab Sheibani; Fahimeh Asadi Amoli
Abstract Purpose This study purposed to evaluate the efficacy of brachytherapy with the modality of ultrasonic hyperthermia in the presence of gold nanoparticles (GNPs) on an ocular retinoblastoma tumor in an animal model of the rabbit. Materials and methods A retinoblastoma tumor was induced by the injection of the human cell line of Y79 in rabbit eyes (n = 41). After two weeks, tumor size reached
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Cell physiological responses of RAW264 macrophage cells to a 50-Hz magnetic field Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-10-29 Chihiro Nishigaki; Maresuke Nakayama; Hidetake Miyata
Abstract Purpose We previously showed that a 0.5-mT, 50-Hz sinusoidal magnetic field (LFMF) enhanced DNA single-strand breaks (SSB) and necrosis in RAW264 macrophages that had been stimulated by bacterial endotoxin (lipopolysaccharide; LPS). LPS enhances production of nitric oxide (NO) and superoxide anion (O2 −) that react with each other to generate peroxynitrite (ONOO−). ONOO− causes DNA strand
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Enhancement in the ATP level and antioxidant capacity of Caenorhabditis elegans under continuous exposure to extremely low-frequency electromagnetic field for multiple generations Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-10-12 Yahong Wang; Yongyan Sun; Ziyan Zhang; Zhihui Li; Hongying Zhang; Yanyan Liao; Chao Tang; Peng Cai
Abstract Purpose Safety concerns about the effects of long-term extremely low-frequency electromagnetic field (ELF-EMF) exposure on human health have been raised. To explore the effects of continuous exposure to ELF-EMF on organisms for multiple generations, we selected Caenorhabditis elegans as a model organism and conducted long-term continuous exposure studies for multiple generations under 20 °C
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Impact of Non-Ionizing Electromagnetic Radiation on Male Infertility: An assessment of the mechanism and consequences Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-02 Rohit Gautam; Eepsita Priyadarshini; Jay Prakash Nirala; Paulraj Rajamani
Abstract Purpose Environment and lifestyle factors is being attributed towards increased instances of male infertility. Rapid technological advancement, results in emission of electromagnetic radiations of different frequency which impacts human both biologically as well as genetically. Devices like cell phone, power line and monitors emit electromagnetic radiation and are a major source of the exposure
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Insight into the evolutionary profile of radio-resistance among insects having intrinsically evolved defence against radiation toxicity. Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-02 Jagdish Gopal Paithankar; Tanhaji Sandu Ghodke; Rajashekhar K. Patil
Abstract Purpose Ionizing radiation (IR) has wide-ranging applications in various fields. In agriculture, pest control is one of the important applications, because insect pests have become a threat for the global agriculture industry. IRs are used routinely to prevent crop loss and to protect stored food commodities. The radio-sterilization or disinfestation treatments are the commonly used procedures
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Total body irradiation models in NHPs – consideration of animal sex and provision of supportive care to advance model development Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-01 Tyler Beach; Simon Authier; Harold S. Javitz; Karen Wong; James Bakke; Janet Gahagen; Deborah I. Bunin; Polly Y. Chang
Abstract Purpose Harmonized animal models are an indispensable tool for the development of safe and effective medical countermeasures (MCMs) against radiation injury, and rhesus macaques (referred herein as NHPs) play a critical role in FDA approval of radiation medical countermeasures for acute and delayed radiation syndromes. Reliance on such models requires that they be well characterized, which
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Unchanged cardiovascular and respiratory outcomes in healthy C57Bl/6 mice after in utero exposure to ionizing radiation Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-12-01 J.H. McEvoy-May; D.E. Jones; L. Stoa; D-L. Dixon; T.C Tai; A.M. Hooker; D.R. Boreham; J.Y. Wilson
Abstract Background Advancements in medical technologies that utilize ionizing radiation have led to improved diagnosis and patient outcomes, however, the effect of ionizing radiation on the patient is still debated. In the case of pregnancy, the potential effects are not only to the mother but also to the fetus. The aim of this study was to determine if exposure from ionizing radiation during pregnancy
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Calculation of microdosimetric spectra for protons using Geant4-DNA and a μ-randomness sampling algorithm for the nanometric structures Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-30 Mojtaba Mokari; Hossein Moeini; Marzieh Soleimani
Abstract Purpose Through introducing stochastic quantities that can be connected to the dimensions of the microscopic structures exposed to radiations, microdosimetry is concerned with the substantive specifications of radiation quality that could help gain insight into radiation effects. Utilizing the μ-randomness method and Geant4-DNA code, we calculated microdosimetry quantities for nanometric structures
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Expression of genes and pathways associated with the B7-CD28 superfamily in response to irradiation of blood cells using 137Cs Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-30 Daner A. Silveira; Fernanda M. Ribeiro; Éder M. Simão; Viviane L. D. Mattos; Evamberto G. Góes
Abstract Purpose DNA damage is one of the main consequences of exposure to ionizing irradiation (IR). Recent studies indicate that IR can modulate the expression of immune system-related genes. However, the effects of IR on the expression of genes and pathways of the B7-CD28 superfamily remain poorly defined. The aim of this study was to evaluate the modulation of genes and pathways related to the
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Collaborative Efforts Are Needed Among the Scientific Community to Advance the Adverse Outcome Pathway Concept in Areas of Radiation Risk Assessment Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-30 Vinita Chauhan; Daniel Villeneuve; Donald Cool
Abstract Background Disease prevention and prediction have led to the generation of phenotypically based methods for deriving the limits of safety across toxicological disciplines. In the ionizing radiation field, human data has formed the basis of the linear-no-threshold (LNT) model for risk estimates. However, uncertainties around its accuracy at low doses and low dose-rates have led to passionate
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Radiofrequency ablation and stereotactic body radiotherapy for hepatocellular carcinoma: Should they clash or reconcile? Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-30 Chai Hong Rim; Hye Yoon Lee; Jung Sun Kim; Hakyoung Kim
Abstract Until a few decades ago, surgical resection was the only valid option for treating hepatocellular carcinoma (HCC). However, various locoregional modalities including arterial-directed therapy, radiofrequency ablation (RFA), and radiotherapy have been recently shown to be effective. RFA is now established as a standard treatment for small localized HCCs, showing oncological results comparable
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Clodronate-Liposomes aggravate irradiation -induced myelosuppression by promoting myeloid differentiation Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-30 Wen Ju; Wenyi Lu; Yurong Bao; Tiantian Sun; Seyram Yao Adzraku; Chunling Fu; Kunming Qi; Xi Zhang; Zhenyu Li; Kailin Xu; Jianlin Qiao; Lingyu Zeng
Abstract Purpose Clodronate-liposomes (Clod-Lip) is an effective candidate drug for treating Chronic Myelomonocytic Leukemia, autoimmune hemolytic anemia and immune thrombocytopenic purpura in mice experiments. But its role in hematopoietic recovery after acute myelosuppression is still unknown. We aim to explore the function and underlining mechanisms of Clod-Lip on hematopoietic reconstitution after
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WAM to SeeSaw Model for Cancer Therapy - Overcoming LQM difficulties - Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-30 Masako Bando; Yuichi Tsunoyama; Kazuyo Suzuki; Hiroshi Toki
Abstract Purpose The assessment of biological effects caused by radiation exposure has been currently carried out with the linear-quadratic (LQ) model as an extension of the linear non-threshold (LNT) model. In this study, we suggest a new mathematical model named as SeaSaw (SS) model, which describes proliferation and cell death effects by taking account of Bergonie-Tribondeau’s law in terms of a
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Summary of the Second Bill Morgan Memorial Symposium: An update on low dose biology, epidemiology, its integration and implications for radiation protection Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-30 Evagelia C. Laiakis; Vinita Chauhan; Mark P. Little; Gayle E. Woloschak; Michael M. Weil; Nobuyuki Hamada
Summary of the Second Bill Morgan Memorial Symposium: An update on low dose biology, epidemiology, its integration and implications for radiation protection. International Journal of Radiation Biology. Accepted 18 November 2020.
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Adaptive time management for patients who have non-small cell lung cancer and underwent definitive radiotherapy: a dosimetric study of different gap duration scenarios Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-19 Aysun Inal; Evrim Duman
Abstract Purpose The purpose of this study was to evaluate the tumor control probability (TCP), normal tissue complication probability (NTCP) and adaptive time management (ATM) in patients who had non-small cell lung cancer (NSCLC) and underwent radiotherapy with same gap length at different treatment weeks. Material and Methods 20 patients’ definitive radiotherapy treatments, completed in 6.5 weeks
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Adverse Outcome Pathways, Key Events and Radiation Risk Assessment Int. J. Radiat. Biol. (IF 2.368) Pub Date : 2020-11-19 R. Julian Preston; Werner Rühm; Edouard I. Azzam; John D. Boice Jr; Simon Bouffler; Kathryn D. Held; Mark P. Little; Roy E. Shore; Igor Shuryak; Michael M. Weil
Abstract Purpose The overall aim of this contribution to the “Second Bill Morgan Memorial Special Issue” is to provide a high-level review of a recent report developed by a Committee for the National Council on Radiation Protection and Measurements (NCRP) titled “Approaches for Integrating Information from Radiation Biology and Epidemiology to Enhance Low-Dose Health Risk Assessment”. It derives from