当前期刊: Nature Communications Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Publisher Correction: Orexin signaling modulates synchronized excitation in the sublaterodorsal tegmental nucleus to stabilize REM sleep
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Hui Feng; Si-Yi Wen; Qi-Cheng Qiao; Yu-Jie Pang; Sheng-Yun Wang; Hao-Yi Li; Jiao Cai; Kai-Xuan Zhang; Jing Chen; Zhi-An Hu; Fen-Lan Luo; Guan-Zhong Wang; Nian Yang; Jun Zhang

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-25
  • Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert -C-radicals
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Chuan Zhu; Ze-Yao Liu; Luning Tang; Heng Zhang; Yu-Feng Zhang; Patrick J. Walsh; Chao Feng

    Despite remarkable recent advances in transition-metal-catalyzed C(sp3)−C cross-coupling reactions, there remain challenging bond formations. One class of such reactions include the formation of tertiary-C(sp3)−C bonds, presumably due to unfavorable steric interactions and competing isomerizations of tertiary alkyl metal intermediates. Reported herein is a Ni-catalyzed migratory 3,3-difluoroallylation

    更新日期:2020-09-25
  • Lead halide perovskite vortex microlasers
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Wenzhao Sun; Yilin Liu; Geyang Qu; Yubin Fan; Wei Dai; Yuhan Wang; Qinghai Song; Jiecai Han; Shumin Xiao

    Lead halide perovskite microlasers have been very promising for versatile optoelectronic applications. However, most perovskite microlasers are linearly polarized with uniform wavefront. The structured laser beams carrying orbital angular momentum have rarely been studied and the applications of perovskites in next-generation optical communications are thus hindered. Herein, we experimentally demonstrate

    更新日期:2020-09-25
  • Thioglycoligase derived from fungal GH3 β-xylosidase is a multi-glycoligase with broad acceptor tolerance
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Manuel Nieto-Domínguez; Beatriz Fernández de Toro; Laura I. de Eugenio; Andrés G. Santana; Lara Bejarano-Muñoz; Zach Armstrong; Juan Antonio Méndez-Líter; Juan Luis Asensio; Alicia Prieto; Stephen G. Withers; Francisco Javier Cañada; María Jesús Martínez

    The synthesis of customized glycoconjugates constitutes a major goal for biocatalysis. To this end, engineered glycosidases have received great attention and, among them, thioglycoligases have proved useful to connect carbohydrates to non-sugar acceptors. However, hitherto the scope of these biocatalysts was considered limited to strong nucleophilic acceptors. Based on the particularities of the GH3

    更新日期:2020-09-25
  • Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Eva Janisiw; Marilina Raices; Fabiola Balmir; Luis F. Paulin; Antoine Baudrimont; Arndt von Haeseler; Judith L. Yanowitz; Verena Jantsch; Nicola Silva

    Poly(ADP-ribosyl)ation is a reversible post-translational modification synthetized by ADP-ribose transferases and removed by poly(ADP-ribose) glycohydrolase (PARG), which plays important roles in DNA damage repair. While well-studied in somatic tissues, much less is known about poly(ADP-ribosyl)ation in the germline, where DNA double-strand breaks are introduced by a regulated program and repaired

    更新日期:2020-09-25
  • The atypical chemokine receptor 3 interacts with Connexin 43 inhibiting astrocytic gap junctional intercellular communication
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Amos Fumagalli; Joyce Heuninck; Anne Pizzoccaro; Enora Moutin; Joyce Koenen; Martial Séveno; Thierry Durroux; Marie-Pierre Junier; Géraldine Schlecht-Louf; Francoise Bachelerie; Dagmar Schütz; Ralf Stumm; Martine J. Smit; Nathalie C. Guérineau; Séverine Chaumont-Dubel; Philippe Marin

    The atypical chemokine receptor 3 (ACKR3) plays a pivotal role in directing the migration of various cellular populations and its over-expression in tumors promotes cell proliferation and invasiveness. The intracellular signaling pathways transducing ACKR3-dependent effects remain poorly characterized, an issue we addressed by identifying the interactome of ACKR3. Here, we report that recombinant ACKR3

    更新日期:2020-09-25
  • Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Jie Zhang; Søren D. Petersen; Tijana Radivojevic; Andrés Ramirez; Andrés Pérez-Manríquez; Eduardo Abeliuk; Benjamín J. Sánchez; Zak Costello; Yu Chen; Michael J. Fero; Hector Garcia Martin; Jens Nielsen; Jay D. Keasling; Michael K. Jensen

    Through advanced mechanistic modeling and the generation of large high-quality datasets, machine learning is becoming an integral part of understanding and engineering living systems. Here we show that mechanistic and machine learning models can be combined to enable accurate genotype-to-phenotype predictions. We use a genome-scale model to pinpoint engineering targets, efficient library construction

    更新日期:2020-09-25
  • Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Gokul Ramaswami; Hyejung Won; Michael J. Gandal; Jillian Haney; Jerry C. Wang; Chloe C. Y. Wong; Wenjie Sun; Shyam Prabhakar; Jonathan Mill; Daniel H. Geschwind

    Autism spectrum disorder (ASD) is a phenotypically and genetically heterogeneous neurodevelopmental disorder. Despite this heterogeneity, previous studies have shown patterns of molecular convergence in post-mortem brain tissue from autistic subjects. Here, we integrate genome-wide measures of mRNA expression, miRNA expression, DNA methylation, and histone acetylation from ASD and control brains to

    更新日期:2020-09-25
  • Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Xinyue Yuan; Manuel Schröter; Marie Engelene J. Obien; Michele Fiscella; Wei Gong; Tetsuhiro Kikuchi; Aoi Odawara; Shuhei Noji; Ikuro Suzuki; Jun Takahashi; Andreas Hierlemann; Urs Frey

    Chronic imaging of neuronal networks in vitro has provided fundamental insights into mechanisms underlying neuronal function. Current labeling and optical imaging methods, however, cannot be used for continuous and long-term recordings of the dynamics and evolution of neuronal networks, as fluorescent indicators can cause phototoxicity. Here, we introduce a versatile platform for label-free, comprehensive

    更新日期:2020-09-25
  • A machine learning Automated Recommendation Tool for synthetic biology
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Tijana Radivojević; Zak Costello; Kenneth Workman; Hector Garcia Martin

    Synthetic biology allows us to bioengineer cells to synthesize novel valuable molecules such as renewable biofuels or anticancer drugs. However, traditional synthetic biology approaches involve ad-hoc engineering practices, which lead to long development times. Here, we present the Automated Recommendation Tool (ART), a tool that leverages machine learning and probabilistic modeling techniques to guide

    更新日期:2020-09-25
  • Radiogenomic signatures reveal multiscale intratumour heterogeneity associated with biological functions and survival in breast cancer
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Ming Fan; Pingping Xia; Robert Clarke; Yue Wang; Lihua Li

    Advanced tumours are often heterogeneous, consisting of subclones with various genetic alterations and functional roles. The precise molecular features that characterize the contributions of multiscale intratumour heterogeneity to malignant progression, metastasis, and poor survival are largely unknown. Here, we address these challenges in breast cancer by defining the landscape of heterogeneous tumour

    更新日期:2020-09-25
  • Characterization of BRCA1 -deficient premalignant tissues and cancers identifies Plekha5 as a tumor metastasis suppressor
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Jianlin Liu; Ragini Adhav; Kai Miao; Sek Man Su; Lihua Mo; Un In Chan; Xin Zhang; Jun Xu; Jianjie Li; Xiaodong Shu; Jianming Zeng; Xu Zhang; Xueying Lyu; Lakhansing Pardeshi; Kaeling Tan; Heng Sun; Koon Ho Wong; Chuxia Deng; Xiaoling Xu

    Single-cell whole-exome sequencing (scWES) is a powerful approach for deciphering intratumor heterogeneity and identifying cancer drivers. So far, however, simultaneous analysis of single nucleotide variants (SNVs) and copy number variations (CNVs) of a single cell has been challenging. By analyzing SNVs and CNVs simultaneously in bulk and single cells of premalignant tissues and tumors from mouse

    更新日期:2020-09-25
  • Transition from light diffusion to localization in three-dimensional amorphous dielectric networks near the band edge
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Jakub Haberko; Luis S. Froufe-Pérez; Frank Scheffold

    Localization of light is the photon analog of electron localization in disordered lattices, for whose discovery Anderson received the Nobel prize in 1977. The question about its existence in open three-dimensional materials has eluded an experimental and full theoretical verification for decades. Here we study numerically electromagnetic vector wave transmittance through realistic digital representations

    更新日期:2020-09-25
  • Emergent solidity of amorphous materials as a consequence of mechanical self-organisation
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Hua Tong; Shiladitya Sengupta; Hajime Tanaka

    Amorphous solids have peculiar properties distinct from crystals. One of the most fundamental mysteries is the emergence of solidity in such nonequilibrium, disordered state without the protection by long-range translational order. A jammed system at zero temperature, although marginally stable, has solidity stemming from the space-spanning force network, which gives rise to the long-range stress correlation

    更新日期:2020-09-25
  • Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Minh Thuan Nguyen Tran; Mohd Khairul Nizam Mohd Khalid; Qi Wang; Jacqueline K. R. Walker; Grace E. Lidgerwood; Kimberley L. Dilworth; Leszek Lisowski; Alice Pébay; Alex W. Hewitt

    Precision genome engineering has dramatically advanced with the development of CRISPR/Cas base editing systems that include cytosine base editors and adenine base editors (ABEs). Herein, we compare the editing profile of circularly permuted and domain-inlaid Cas9 base editors, and find that on-target editing is largely maintained following their intradomain insertion, but that structural permutation

    更新日期:2020-09-25
  • Mycobacterium tuberculosis progresses through two phases of latent infection in humans
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Roberto Colangeli; Aditi Gupta; Solange Alves Vinhas; Uma Deepthi Chippada Venkata; Soyeon Kim; Courtney Grady; Edward C. Jones-López; Patricia Soteropoulos; Moisés Palaci; Patrícia Marques-Rodrigues; Padmini Salgame; Jerrold J. Ellner; Reynaldo Dietze; David Alland

    Little is known about the physiology of latent Mycobacterium tuberculosis infection. We studied the mutational rates of 24 index tuberculosis (TB) cases and their latently infected household contacts who developed active TB up to 5.25 years later, as an indication of bacterial physiological state and possible generation times during latent TB infection in humans. Here we report that the rate of new

    更新日期:2020-09-25
  • Molecular correlates of cisplatin-based chemotherapy response in muscle invasive bladder cancer by integrated multi-omics analysis
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Ann Taber; Emil Christensen; Philippe Lamy; Iver Nordentoft; Frederik Prip; Sia Viborg Lindskrog; Karin Birkenkamp-Demtröder; Trine Line Hauge Okholm; Michael Knudsen; Jakob Skou Pedersen; Torben Steiniche; Mads Agerbæk; Jørgen Bjerggaard Jensen; Lars Dyrskjøt

    Overtreatment with cisplatin-based chemotherapy is a major issue in the management of muscle-invasive bladder cancer (MIBC), and currently none of the reported biomarkers for predicting response have been implemented in the clinic. Here we perform a comprehensive multi-omics analysis (genomics, transcriptomics, epigenomics and proteomics) of 300 MIBC patients treated with chemotherapy (neoadjuvant

    更新日期:2020-09-25
  • Face selective patches in marmoset frontal cortex
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    David J. Schaeffer; Janahan Selvanayagam; Kevin D. Johnston; Ravi S. Menon; Winrich A. Freiwald; Stefan Everling

    In humans and macaque monkeys, socially relevant face processing is accomplished via a distributed functional network that includes specialized patches in frontal cortex. It is unclear whether a similar network exists in New World primates, who diverged ~35 million years from Old World primates. The common marmoset is a New World primate species ideally placed to address this question given their complex

    更新日期:2020-09-25
  • Superconductivity mediated by polar modes in ferroelectric metals
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    C. Enderlein; J. Ferreira de Oliveira; D. A. Tompsett; E. Baggio Saitovitch; S. S. Saxena; G. G. Lonzarich; S. E. Rowley

    The occurrence of superconductivity in doped SrTiO3 at low carrier densities points to the presence of an unusually strong pairing interaction that has eluded understanding for several decades. We report experimental results showing the pressure dependence of the superconducting transition temperature, Tc, near to optimal doping that sheds light on the nature of this interaction. We find that Tc increases

    更新日期:2020-09-25
  • Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Mohammad Zulkifli; John K. Neff; Shrishiv A. Timbalia; Natalie M. Garza; Yingqi Chen; Jeramie D. Watrous; Marta Murgia; Prachi P. Trivedi; Steven K. Anderson; Dhanendra Tomar; Roland Nilsson; Muniswamy Madesh; Mohit Jain; Vishal M. Gohil

    Mitochondria house evolutionarily conserved pathways of carbon and nitrogen metabolism that drive cellular energy production. Mitochondrial bioenergetics is regulated by calcium uptake through the mitochondrial calcium uniporter (MCU), a multi-protein complex whose assembly in the inner mitochondrial membrane is facilitated by the scaffold factor MCUR1. Intriguingly, many fungi that lack MCU contain

    更新日期:2020-09-25
  • Engineering and application of a biosensor with focused ligand specificity
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Dennis Della Corte; Hugo L. van Beek; Falk Syberg; Marcus Schallmey; Felix Tobola; Kai U. Cormann; Christine Schlicker; Philipp T. Baumann; Karin Krumbach; Sascha Sokolowsky; Connor J. Morris; Alexander Grünberger; Eckhard Hofmann; Gunnar F. Schröder; Jan Marienhagen

    Cell factories converting bio-based precursors to chemicals present an attractive avenue to a sustainable economy, yet screening of genetically diverse strain libraries to identify the best-performing whole-cell biocatalysts is a low-throughput endeavor. For this reason, transcriptional biosensors attract attention as they allow the screening of vast libraries when used in combination with fluorescence-activated

    更新日期:2020-09-25
  • DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Qi Liu; Qing-tao He; Xiaoxuan Lyu; Fan Yang; Zhong-liang Zhu; Peng Xiao; Zhao Yang; Feng Zhang; Zhao-ya Yang; Xiao-yan Wang; Peng Sun; Qian-wen Wang; Chang-xiu Qu; Zheng Gong; Jing-yu Lin; Zhen Xu; Shao-le Song; Shen-ming Huang; Sheng-chao Guo; Ming-jie Han; Kong-kai Zhu; Xin Chen; Alem W. Kahsai; Kun-Hong Xiao; Wei Kong; Fa-hui Li; Ke Ruan; Zi-jian Li; Xiao Yu; Xiao-gang Niu; Chang-wen Jin; Jiangyun

    Characterization of the dynamic conformational changes in membrane protein signaling complexes by nuclear magnetic resonance (NMR) spectroscopy remains challenging. Here we report the site-specific incorporation of 4-trimethylsilyl phenylalanine (TMSiPhe) into proteins, through genetic code expansion. Crystallographic analysis revealed structural changes that reshaped the TMSiPhe-specific amino-acyl

    更新日期:2020-09-25
  • A data-driven simulation platform to predict cultivars’ performances under uncertain weather conditions
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Gustavo de los Campos; Paulino Pérez-Rodríguez; Matthieu Bogard; David Gouache; José Crossa

    In most crops, genetic and environmental factors interact in complex ways giving rise to substantial genotype-by-environment interactions (G×E). We propose that computer simulations leveraging field trial data, DNA sequences, and historical weather records can be used to tackle the longstanding problem of predicting cultivars’ future performances under largely uncertain weather conditions. We present

    更新日期:2020-09-25
  • A trimeric Cr RLK1L-LLG1 complex genetically modulates SUMM2-mediated autoimmunity
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Yanyan Huang; Chuanchun Yin; Jun Liu; Baomin Feng; Dongdong Ge; Liang Kong; Fausto Andres Ortiz-Morea; Julia Richter; Marie-Theres Hauser; Wen-Ming Wang; Libo Shan; Ping He

    Cell death is intrinsically linked with immunity. Disruption of an immune-activated MAPK cascade, consisting of MEKK1, MKK1/2, and MPK4, triggers cell death and autoimmunity through the nucleotide-binding leucine-rich repeat (NLR) protein SUMM2 and the MAPK kinase kinase MEKK2. In this study, we identify a Catharanthus roseus receptor-like kinase 1-like (CrRLK1L), named LETUM2/MEDOS1 (LET2/MDS1), and

    更新日期:2020-09-25
  • Transfer learning enables the molecular transformer to predict regio- and stereoselective reactions on carbohydrates
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Giorgio Pesciullesi; Philippe Schwaller; Teodoro Laino; Jean-Louis Reymond

    Organic synthesis methodology enables the synthesis of complex molecules and materials used in all fields of science and technology and represents a vast body of accumulated knowledge optimally suited for deep learning. While most organic reactions involve distinct functional groups and can readily be learned by deep learning models and chemists alike, regio- and stereoselective transformations are

    更新日期:2020-09-25
  • Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Manish Chamoli; Anita Goyala; Syed Shamsh Tabrez; Atif Ahmed Siddiqui; Anupama Singh; Adam Antebi; Gordon J. Lithgow; Jennifer L. Watts; Arnab Mukhopadhyay

    The metabolic state of an organism instructs gene expression modalities, leading to changes in complex life history traits, such as longevity. Dietary restriction (DR), which positively affects health and life span across species, leads to metabolic reprogramming that enhances utilisation of fatty acids for energy generation. One direct consequence of this metabolic shift is the upregulation of cytoprotective

    更新日期:2020-09-25
  • Trait phenomenological control predicts experience of mirror synaesthesia and the rubber hand illusion
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    P. Lush; V. Botan; R. B. Scott; A. K. Seth; J. Ward; Z. Dienes

    In hypnotic responding, expectancies arising from imaginative suggestion drive striking experiential changes (e.g., hallucinations) — which are experienced as involuntary — according to a normally distributed and stable trait ability (hypnotisability). Such experiences can be triggered by implicit suggestion and occur outside the hypnotic context. In large sample studies (of 156, 404 and 353 participants)

    更新日期:2020-09-25
  • Plasmonic antenna coupling to hyperbolic phonon-polaritons for sensitive and fast mid-infrared photodetection with graphene
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-25
    Sebastián Castilla; Ioannis Vangelidis; Varun-Varma Pusapati; Jordan Goldstein; Marta Autore; Tetiana Slipchenko; Khannan Rajendran; Seyoon Kim; Kenji Watanabe; Takashi Taniguchi; Luis Martín-Moreno; Dirk Englund; Klaas-Jan Tielrooij; Rainer Hillenbrand; Elefterios Lidorikis; Frank H. L. Koppens

    Integrating and manipulating the nano-optoelectronic properties of Van der Waals heterostructures can enable unprecedented platforms for photodetection and sensing. The main challenge of infrared photodetectors is to funnel the light into a small nanoscale active area and efficiently convert it into an electrical signal. Here, we overcome all of those challenges in one device, by efficient coupling

    更新日期:2020-09-25
  • Publisher Correction: Reconciling qualitative, abstract, and scalable modeling of biological networks
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Loïc Paulevé; Juraj Kolčák; Thomas Chatain; Stefan Haar

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-24
  • Porous carbon nanowire array for surface-enhanced Raman spectroscopy
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Nan Chen; Ting-Hui Xiao; Zhenyi Luo; Yasutaka Kitahama; Kotaro Hiramatsu; Naoki Kishimoto; Tamitake Itoh; Zhenzhou Cheng; Keisuke Goda

    Surface-enhanced Raman spectroscopy (SERS) is a powerful tool for vibrational spectroscopy as it provides several orders of magnitude higher sensitivity than inherently weak spontaneous Raman scattering by exciting localized surface plasmon resonance (LSPR) on metal substrates. However, SERS can be unreliable for biomedical use since it sacrifices reproducibility, uniformity, biocompatibility, and

    更新日期:2020-09-24
  • Combinatorial entropy behaviour leads to range selective binding in ligand-receptor interactions
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Meng Liu; Azzurra Apriceno; Miguel Sipin; Edoardo Scarpa; Laura Rodriguez-Arco; Alessandro Poma; Gabriele Marchello; Giuseppe Battaglia; Stefano Angioletti-Uberti

    From viruses to nanoparticles, constructs functionalized with multiple ligands display peculiar binding properties that only arise from multivalent effects. Using statistical mechanical modelling, we describe here how multivalency can be exploited to achieve what we dub range selectivity, that is, binding only to targets bearing a number of receptors within a specified range. We use our model to characterise

    更新日期:2020-09-24
  • Cross-regulation of viral kinases with cyclin A secures shutoff of host DNA synthesis
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Boris Bogdanow; Max Schmidt; Henry Weisbach; Iris Gruska; Barbara Vetter; Koshi Imami; Eleonore Ostermann; Wolfram Brune; Matthias Selbach; Christian Hagemeier; Lüder Wiebusch

    Herpesviruses encode conserved protein kinases (CHPKs) to stimulate phosphorylation-sensitive processes during infection. How CHPKs bind to cellular factors and how this impacts their regulatory functions is poorly understood. Here, we use quantitative proteomics to determine cellular interaction partners of human herpesvirus (HHV) CHPKs. We find that CHPKs can target key regulators of transcription

    更新日期:2020-09-24
  • PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Qi Peng; Xiangyan Qiu; Zihan Zhang; Silin Zhang; Yuanyuan Zhang; Yong Liang; Jingya Guo; Hua Peng; Mingyi Chen; Yang-Xin Fu; Haidong Tang

    Immune checkpoint blockade therapies have shown clinical promise in a variety of cancers, but how tumor-infiltrating T cells are activated remains unclear. In this study, we explore the functions of PD-L1 on dendritic cells (DCs), which highly express PD-L1. We observe that PD-L1 on DC plays a critical role in limiting T cell responses. Type 1 conventional DCs are essential for PD-L1 blockade and they

    更新日期:2020-09-24
  • Persistent and reversible solid iodine electrodeposition in nanoporous carbons
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Christian Prehal; Harald Fitzek; Gerald Kothleitner; Volker Presser; Bernhard Gollas; Stefan A. Freunberger; Qamar Abbas

    Aqueous iodine based electrochemical energy storage is considered a potential candidate to improve sustainability and performance of current battery and supercapacitor technology. It harnesses the redox activity of iodide, iodine, and polyiodide species in the confined geometry of nanoporous carbon electrodes. However, current descriptions of the electrochemical reaction mechanism to interconvert these

    更新日期:2020-09-24
  • Thermal transport of helium-3 in a strongly confining channel
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    D. Lotnyk; A. Eyal; N. Zhelev; T. S. Abhilash; E. N. Smith; M. Terilli; J. Wilson; E. Mueller; D. Einzel; J. Saunders; J. M. Parpia

    The investigation of transport properties in normal liquid helium-3 and its topological superfluid phases provides insights into related phenomena in electron fluids, topological materials, and putative topological superconductors. It relies on the measurement of mass, heat, and spin currents, due to system neutrality. Of particular interest is transport in strongly confining channels of height approaching

    更新日期:2020-09-24
  • Anomalous supply shortages from dynamic pricing in on-demand mobility
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Malte Schröder; David-Maximilian Storch; Philip Marszal; Marc Timme

    Dynamic pricing schemes are increasingly employed across industries to maintain a self-organized balance of demand and supply. However, throughout complex dynamical systems, unintended collective states exist that may compromise their function. Here we reveal how dynamic pricing may induce demand-supply imbalances instead of preventing them. Combining game theory and time series analysis of dynamic

    更新日期:2020-09-24
  • Rapid vessel segmentation and reconstruction of head and neck angiograms using 3D convolutional neural network
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Fan Fu; Jianyong Wei; Miao Zhang; Fan Yu; Yueting Xiao; Dongdong Rong; Yi Shan; Yan Li; Cheng Zhao; Fangzhou Liao; Zhenghan Yang; Yuehua Li; Yingmin Chen; Ximing Wang; Jie Lu

    The computed tomography angiography (CTA) postprocessing manually recognized by technologists is extremely labor intensive and error prone. We propose an artificial intelligence reconstruction system supported by an optimized physiological anatomical-based 3D convolutional neural network that can automatically achieve CTA reconstruction in healthcare services. This system is trained and tested with

    更新日期:2020-09-24
  • Constructing phase boundary in AgNbO 3 antiferroelectrics: pathway simultaneously achieving high energy density and efficiency
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Nengneng Luo; Kai Han; Matthew J. Cabral; Xiaozhou Liao; Shujun Zhang; Changzhong Liao; Guangzu Zhang; Xiyong Chen; Qin Feng; Jing-Feng Li; Yuezhou Wei

    Dielectric capacitors with high energy storage density (Wrec) and efficiency (η) are in great demand for high/pulsed power electronic systems, but the state-of-the-art lead-free dielectric materials are facing the challenge of increasing one parameter at the cost of the other. Herein, we report that high Wrec of 6.3 J cm-3 with η of 90% can be simultaneously achieved by constructing a room temperature

    更新日期:2020-09-24
  • Machine learning identifies scale-free properties in disordered materials
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Sunkyu Yu; Xianji Piao; Namkyoo Park

    The vast amount of design freedom in disordered systems expands the parameter space for signal processing. However, this large degree of freedom has hindered the deterministic design of disordered systems for target functionalities. Here, we employ a machine learning approach for predicting and designing wave-matter interactions in disordered structures, thereby identifying scale-free properties for

    更新日期:2020-09-24
  • Correlation between the static and dynamic responses of organic single-crystal field-effect transistors
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Taiki Sawada; Akifumi Yamamura; Mari Sasaki; Kayo Takahira; Toshihiro Okamoto; Shun Watanabe; Jun Takeya

    Transistors, the most important logic elements, are maintained under dynamic influence during circuit operations. Practically, circuit design protocols and frequency responsibility should stem from a perfect agreement between the static and dynamic properties. However, despite remarkable improvements in mobility for organic semiconductors, the correlation between the device performances achieved under

    更新日期:2020-09-24
  • Very-Low-Frequency transmitters bifurcate energetic electron belt in near-earth space
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Man Hua; Wen Li; Binbin Ni; Qianli Ma; Alex Green; Xiaochen Shen; Seth G. Claudepierre; Jacob Bortnik; Xudong Gu; Song Fu; Zheng Xiang; Geoffrey D. Reeves

    Very-Low-Frequency (VLF) transmitters operate worldwide mostly at frequencies of 10–30 kilohertz for submarine communications. While it has been of intense scientific interest and practical importance to understand whether VLF transmitters can affect the natural environment of charged energetic particles, for decades there remained little direct observational evidence that revealed the effects of these

    更新日期:2020-09-24
  • Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Brendan A. Daisley; Ryan M. Chanyi; Kamilah Abdur-Rashid; Kait F. Al; Shaeley Gibbons; John A. Chmiel; Hannah Wilcox; Gregor Reid; Amanda Anderson; Malcolm Dewar; Shiva M. Nair; Joseph Chin; Jeremy P. Burton

    Abiraterone acetate (AA) is an inhibitor of androgen biosynthesis, though this cannot fully explain its efficacy against androgen-independent prostate cancer. Here, we demonstrate that androgen deprivation therapy depletes androgen-utilizing Corynebacterium spp. in prostate cancer patients and that oral AA further enriches for the health-associated commensal, Akkermansia muciniphila. Functional inferencing

    更新日期:2020-09-24
  • Structural basis of mammalian mucin processing by the human gut O -glycopeptidase OgpA from Akkermansia muciniphila
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Beatriz Trastoy; Andreas Naegeli; Itxaso Anso; Jonathan Sjögren; Marcelo E. Guerin

    Akkermansia muciniphila is a mucin-degrading bacterium commonly found in the human gut that promotes a beneficial effect on health, likely based on the regulation of mucus thickness and gut barrier integrity, but also on the modulation of the immune system. In this work, we focus in OgpA from A. muciniphila, an O-glycopeptidase that exclusively hydrolyzes the peptide bond N-terminal to serine or threonine

    更新日期:2020-09-24
  • ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Gururaj Rao Kidiyoor; Qingsen Li; Giulia Bastianello; Christopher Bruhn; Irene Giovannetti; Adhil Mohamood; Galina V. Beznoussenko; Alexandre Mironov; Matthew Raab; Matthieu Piel; Umberto Restuccia; Vittoria Matafora; Angela Bachi; Sara Barozzi; Dario Parazzoli; Emanuela Frittoli; Andrea Palamidessi; Tito Panciera; Stefano Piccolo; Giorgio Scita; Paolo Maiuri; Kristina M. Havas; Zhong-Wei Zhou; Amit

    ATR responds to mechanical stress at the nuclear envelope and mediates envelope-associated repair of aberrant topological DNA states. By combining microscopy, electron microscopic analysis, biophysical and in vivo models, we report that ATR-defective cells exhibit altered nuclear plasticity and YAP delocalization. When subjected to mechanical stress or undergoing interstitial migration, ATR-defective

    更新日期:2020-09-24
  • Copper catalysis at operando conditions—bridging the gap between single nanoparticle probing and catalyst-bed-averaging
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    David Albinsson; Astrid Boje; Sara Nilsson; Christopher Tiburski; Anders Hellman; Henrik Ström; Christoph Langhammer

    In catalysis, nanoparticles enable chemical transformations and their structural and chemical fingerprints control activity. To develop understanding of such fingerprints, methods studying catalysts at realistic conditions have proven instrumental. Normally, these methods either probe the catalyst bed with low spatial resolution, thereby averaging out single particle characteristics, or probe an extremely

    更新日期:2020-09-24
  • Giant voltage-induced modification of magnetism in micron-scale ferromagnetic metals by hydrogen charging
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Xinglong Ye; Harish K. Singh; Hongbin Zhang; Holger Geßwein; Mohammed Reda Chellali; Ralf Witte; Alan Molinari; Konstantin Skokov; Oliver Gutfleisch; Horst Hahn; Robert Kruk

    Owing to electric-field screening, the modification of magnetic properties in ferromagnetic metals by applying small voltages is restricted to a few atomic layers at the surface of metals. Bulk metallic systems usually do not exhibit any magneto-electric effect. Here, we report that the magnetic properties of micron-scale ferromagnetic metals can be modulated substantially through electrochemically-controlled

    更新日期:2020-09-24
  • MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Yingzhong Li; Nikola A. Ivica; Ting Dong; Dimitrios P. Papageorgiou; Yanpu He; Douglas R. Brown; Marianna Kleyman; Guangan Hu; Walter W. Chen; Lucas B. Sullivan; Amanda Del Rosario; Paula T. Hammond; Matthew G. Vander Heiden; Jianzhu Chen

    ATP synthesis and thermogenesis are two critical outputs of mitochondrial respiration. How these outputs are regulated to balance the cellular requirement for energy and heat is largely unknown. Here we show that major facilitator superfamily domain containing 7C (MFSD7C) uncouples mitochondrial respiration to switch ATP synthesis to thermogenesis in response to heme. When heme levels are low, MSFD7C

    更新日期:2020-09-24
  • Raman-guided subcellular pharmaco-metabolomics for metastatic melanoma cells
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Jiajun Du; Yapeng Su; Chenxi Qian; Dan Yuan; Kun Miao; Dongkwan Lee; Alphonsus H. C. Ng; Reto S. Wijker; Antoni Ribas; Raphael D. Levine; James R. Heath; Lu Wei

    Non-invasively probing metabolites within single live cells is highly desired but challenging. Here we utilize Raman spectro-microscopy for spatial mapping of metabolites within single cells, with the specific goal of identifying druggable metabolic susceptibilities from a series of patient-derived melanoma cell lines. Each cell line represents a different characteristic level of cancer cell de-differentiation

    更新日期:2020-09-24
  • Laser-induced graphitization of polydopamine leads to enhanced mechanical performance while preserving multifunctionality
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Kyueui Lee; Minok Park; Katerina G. Malollari; Jisoo Shin; Sally M. Winkler; Yuting Zheng; Jung Hwan Park; Costas P. Grigoropoulos; Phillip B. Messersmith

    Polydopamine (PDA) is a simple and versatile conformal coating material that has been proposed for a variety of uses; however in practice its performance is often hindered by poor mechanical properties and high roughness. Here, we show that blue-diode laser annealing dramatically improves mechanical performance and reduces roughness of PDA coatings. Laser-annealed PDA (LAPDA) was shown to be >100-fold

    更新日期:2020-09-24
  • Optoribogenetic control of regulatory RNA molecules
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Sebastian Pilsl; Charles Morgan; Moujab Choukeife; Andreas Möglich; Günter Mayer

    Short regulatory RNA molecules underpin gene expression and govern cellular state and physiology. To establish an alternative layer of control over these processes, we generated chimeric regulatory RNAs that interact reversibly and light-dependently with the light-oxygen-voltage photoreceptor PAL. By harnessing this interaction, the function of micro RNAs (miRs) and short hairpin (sh) RNAs in mammalian

    更新日期:2020-09-24
  • The social and environmental complexities of extracting energy transition metals
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Éléonore Lèbre; Martin Stringer; Kamila Svobodova; John R. Owen; Deanna Kemp; Claire Côte; Andrea Arratia-Solar; Rick K. Valenta

    Environmental, social and governance pressures should feature in future scenario planning about the transition to a low carbon future. As low-carbon energy technologies advance, markets are driving demand for energy transition metals. Increased extraction rates will augment the stress placed on people and the environment in extractive locations. To quantify this stress, we develop a set of global composite

    更新日期:2020-09-24
  • Fault valving and pore pressure evolution in simulations of earthquake sequences and aseismic slip
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Weiqiang Zhu; Kali L. Allison; Eric M. Dunham; Yuyun Yang

    Fault-zone fluids control effective normal stress and fault strength. While most earthquake models assume a fixed pore fluid pressure distribution, geologists have documented fault valving behavior, that is, cyclic changes in pressure and unsteady fluid migration along faults. Here we quantify fault valving through 2-D antiplane shear simulations of earthquake sequences on a strike-slip fault with

    更新日期:2020-09-24
  • A possible universal role for mRNA secondary structure in bacterial translation revealed using a synthetic operon
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Yonatan Chemla; Michael Peeri; Mathias Luidor Heltberg; Jerry Eichler; Mogens Høgh Jensen; Tamir Tuller; Lital Alfonta

    In bacteria, translation re-initiation is crucial for synthesizing proteins encoded by genes that are organized into operons. The mechanisms regulating translation re-initiation remain, however, poorly understood. We now describe the ribosome termination structure (RTS), a conserved and stable mRNA secondary structure localized immediately downstream of stop codons, and provide experimental evidence

    更新日期:2020-09-24
  • Fabrication of a novel magnetic topological heterostructure and temperature evolution of its massive Dirac cone
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    T. Hirahara; M. M. Otrokov; T. T. Sasaki; K. Sumida; Y. Tomohiro; S. Kusaka; Y. Okuyama; S. Ichinokura; M. Kobayashi; Y. Takeda; K. Amemiya; T. Shirasawa; S. Ideta; K. Miyamoto; K. Tanaka; S. Kuroda; T. Okuda; K. Hono; S. V. Eremeev; E. V. Chulkov

    Materials that possess nontrivial topology and magnetism is known to exhibit exotic quantum phenomena such as the quantum anomalous Hall effect. Here, we fabricate a novel magnetic topological heterostructure Mn4Bi2Te7/Bi2Te3 where multiple magnetic layers are inserted into the topmost quintuple layer of the original topological insulator Bi2Te3. A massive Dirac cone (DC) with a gap of 40–75 meV at

    更新日期:2020-09-24
  • Bone morphogenetic protein 7 promotes resistance to immunotherapy
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Maria Angelica Cortez; Fatemeh Masrorpour; Cristina Ivan; Jie Zhang; Ahmed Younes; Yue Lu; Marcos R Estecio; Hampartsoum B. Barsoumian; Hari Menon; Mauricio da Silva Caetano; Rishab Ramapriyan; Jonathan E. Schoenhals; Xiaohong Wang; Ferdinandos Skoulidis; Mark D. Wasley; George Calin; Patrick Hwu; James W. Welsh

    Immunotherapies revolutionized cancer treatment by harnessing the immune system to target cancer cells. However, most patients are resistant to immunotherapies and the mechanisms underlying this resistant is still poorly understood. Here, we report that overexpression of BMP7, a member of the TGFB superfamily, represents a mechanism for resistance to anti-PD1 therapy in preclinical models and in patients

    更新日期:2020-09-24
  • Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Hemant M. Kocher; Bristi Basu; Fieke E. M. Froeling; Debashis Sarker; Sarah Slater; Dominic Carlin; Nandita M. deSouza; Katja N. De Paepe; Michelle R. Goulart; Christine Hughes; Ahmet Imrali; Rhiannon Roberts; Maria Pawula; Richard Houghton; Cheryl Lawrence; Yathushan Yogeswaran; Kelly Mousa; Carike Coetzee; Peter Sasieni; Aaron Prendergast; David J. Propper

    Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma (PDAC) growth. Here, in a phase Ib, dose escalation and expansion, trial for patients with advanced, unresectable PDAC (n = 27), ATRA is re-purposed as a stromal-targeting agent in combination with gemcitabine-nab-paclitaxel

    更新日期:2020-09-24
  • Functional genetic encoding of sulfotyrosine in mammalian cells
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-24
    Xinyuan He; Yan Chen; Daisy Guiza Beltran; Maia Kelly; Bin Ma; Justin Lawrie; Feng Wang; Eric Dodds; Limei Zhang; Jiantao Guo; Wei Niu

    Protein tyrosine O-sulfation (PTS) plays a crucial role in extracellular biomolecular interactions that dictate various cellular processes. It also involves in the development of many human diseases. Regardless of recent progress, our current understanding of PTS is still in its infancy. To promote and facilitate relevant studies, a generally applicable method is needed to enable efficient expression

    更新日期:2020-09-24
  • Author Correction: The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells.
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-23
    Xiao Gao,Qingwei Wang,Ying Wang,Jiang Liu,Shuang Liu,Jian Liu,Xingli Zhou,Li Zhou,Hui Chen,Linian Pan,Jiwei Chen,Da Wang,Qing Zhang,Shihui Shen,Yu Xiao,Zhipeng Wu,Yiyun Cheng,Geng Chen,Syeda Kubra,Jun Qin,Lan Huang,Pei Zhang,Chuangui Wang,Robb E Moses,David M Lonard,Bert W O' Malley,Fuad Fares,Bianhong Zhang,Xiaotao Li,Lei Li,Jianru Xiao

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-09-23
  • Conversion of anilines to chiral benzylic amines via formal one-carbon insertion into aromatic C-N bonds.
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-23
    Lei Li,Min Yang,Qiuqin He,Renhua Fan

    Insertion of atoms into aromatic carbon-nitrogen bonds is an appealing method for the synthesis of nitrogen-containing molecules and it has the advantage of the availability and abundance of anilines. However, the direct cleavage of aromatic carbon-nitrogen bonds is challenging due to the particularly inert and stable nature of these bonds. Here we report a formal, enantioselective one-carbon insertion

    更新日期:2020-09-23
  • Design of highly efficient deep-blue organic afterglow through guest sensitization and matrices rigidification.
    Nat. Commun. (IF 12.121) Pub Date : 2020-09-23
    Shen Xu,Wu Wang,Hui Li,Jingyu Zhang,Runfeng Chen,Shuang Wang,Chao Zheng,Guichuan Xing,Chunyuan Song,Wei Huang

    Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecules to sensitize the triplet exciton population of guest and water implement to suppress

    更新日期:2020-09-23
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
物理学研究前沿热点精选期刊推荐
chemistry
自然职位线上招聘会
欢迎报名注册2020量子在线大会
化学领域亟待解决的问题
材料学研究精选新
GIANT
ACS ES&T Engineering
ACS ES&T Water
ACS Publications填问卷
屿渡论文,编辑服务
阿拉丁试剂right
南昌大学
王辉
南方科技大学
彭小水
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
天合科研
x-mol收录
赵延川
李霄羽
廖矿标
朱守非
试剂库存
down
wechat
bug