当前期刊: Nature Communications Go to current issue    加入关注   
显示样式:        排序: IF: - GO 导出
我的关注
我的收藏
您暂时未登录!
登录
  • Author Correction: A strong and ductile medium-entropy alloy resists hydrogen embrittlement and corrosion
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-02
    Hong Luo; Seok Su Sohn; Wenjun Lu; Linlin Li; Xiaogang Li; Chandrahaasan K. Soundararajan; Waldemar Krieger; Zhiming Li; Dierk Raabe

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-02
  • Publisher Correction: Glacial–interglacial Nd isotope variability of North Atlantic Deep Water modulated by North American ice sheet
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-01
    Ning Zhao; Delia W. Oppo; Kuo-Fang Huang; Jacob N. W. Howe; Jerzy Blusztajn; Lloyd D. Keigwin

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-07-01
  • High-altitude populations need special considerations for COVID-19
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-01
    Arnar Breevoort; Giovanni A. Carosso; Mohammed A. Mostajo-Radji

    The atmospheric pressure that decreases with altitude affects lung physiology. However, these changes in physiology are not usually considered in ventilator design and testing. We argue that high altitude human populations require special attention to access the international supply of ventilators.

    更新日期:2020-07-01
  • Impact of dual-layer solid-electrolyte interphase inhomogeneities on early-stage defect formation in Si electrodes
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-01
    Chunguang Chen; Tao Zhou; Dmitri L. Danilov; Lu Gao; Svenja Benning; Nino Schön; Samuel Tardif; Hugh Simons; Florian Hausen; Tobias U. Schülli; R.-A. Eichel; Peter H. L. Notten

    While intensive efforts have been devoted to studying the nature of the solid-electrolyte interphase (SEI), little attention has been paid to understanding its role in the mechanical failures of electrodes. Here we unveil the impact of SEI inhomogeneities on early-stage defect formation in Si electrodes. Buried under the SEI, these early-stage defects are inaccessible by most surface-probing techniques

    更新日期:2020-07-01
  • A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-01
    Tadatoshi Sato; Shiv Verma; Christian D. Castro Andrade; Maureen Omeara; Nia Campbell; Jialiang S. Wang; Murat Cetinbas; Audrey Lang; Brandon J. Ausk; Daniel J. Brooks; Ruslan I. Sadreyev; Henry M. Kronenberg; David Lagares; Yuhei Uda; Paola Divieti Pajevic; Mary L. Bouxsein; Ted S. Gross; Marc N. Wein

    Osteocytes, cells ensconced within mineralized bone matrix, are the primary skeletal mechanosensors. Osteocytes sense mechanical cues by changes in fluid flow shear stress (FFSS) across their dendritic projections. Loading-induced reductions of osteocytic Sclerostin (encoded by Sost) expression stimulates new bone formation. However, the molecular steps linking mechanotransduction and Sost suppression

    更新日期:2020-07-01
  • Flexible experimental designs for valid single-cell RNA-sequencing experiments allowing batch effects correction
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-01
    Fangda Song; Ga Ming Angus Chan; Yingying Wei

    Despite their widespread applications, single-cell RNA-sequencing (scRNA-seq) experiments are still plagued by batch effects and dropout events. Although the completely randomized experimental design has frequently been advocated to control for batch effects, it is rarely implemented in real applications due to time and budget constraints. Here, we mathematically prove that under two more flexible

    更新日期:2020-07-01
  • NSs amyloid formation is associated with the virulence of Rift Valley fever virus in mice
    Nat. Commun. (IF 12.121) Pub Date : 2020-07-01
    Psylvia Léger; Eliana Nachman; Karsten Richter; Carole Tamietti; Jana Koch; Robin Burk; Susann Kummer; Qilin Xin; Megan Stanifer; Michèle Bouloy; Steeve Boulant; Hans-Georg Kräusslich; Xavier Montagutelli; Marie Flamand; Carmen Nussbaum-Krammer; Pierre-Yves Lozach

    Amyloid fibrils result from the aggregation of host cell-encoded proteins, many giving rise to specific human illnesses such as Alzheimer’s disease. Here we show that the major virulence factor of Rift Valley fever virus, the protein NSs, forms filamentous structures in the brain of mice and affects mortality. NSs assembles into nuclear and cytosolic disulfide bond-dependent fibrillary aggregates in

    更新日期:2020-07-01
  • Author Correction: Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-30
    Hebah A. Sindi; Giusy Russomanno; Sandro Satta; Vahitha B. Abdul-Salam; Kyeong Beom Jo; Basma Qazi-Chaudhry; Alexander J. Ainscough; Robert Szulcek; Harm Jan Bogaard; Claire C. Morgan; Soni S. Pullamsetti; Mai M. Alzaydi; Christopher J. Rhodes; Roberto Piva; Christina A. Eichstaedt; Ekkehard Grünig; Martin R. Wilkins; Beata Wojciak-Stothard

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    更新日期:2020-06-30
  • A framework for on-implant spike sorting based on salient feature selection
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-30
    MohammadAli Shaeri; Amir M. Sodagar

    On-implant spike sorting methods employ static feature extraction/selection techniques to minimize the hardware cost. Here we propose a novel framework for real-time spike sorting based on dynamic selection of features. We select salient features that maximize the geometric-mean of between-class distances as well as the associated homogeneity index effectively to best discriminate spikes for classification

    更新日期:2020-06-30
  • The increasing likelihood of temperatures above 30 to 40 °C in the United Kingdom
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-30
    Nikolaos Christidis; Mark McCarthy; Peter A. Stott

    As European heatwaves become more severe, summers in the United Kingdom (UK) are also getting warmer. The UK record temperature of 38.7 °C set in Cambridge in July 2019 prompts the question of whether exceeding 40 °C is now within reach. Here, we show how human influence is increasing the likelihood of exceeding 30, 35 and 40 °C locally. We utilise observations to relate local to UK mean extremes and

    更新日期:2020-06-30
  • Structural characterization of a novel human adeno-associated virus capsid with neurotropic properties
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-30
    Hung-Lun Hsu; Alexander Brown; Anna B. Loveland; Anoushka Lotun; Meiyu Xu; Li Luo; Guangchao Xu; Jia Li; Lingzhi Ren; Qin Su; Dominic J. Gessler; Yuquan Wei; Phillip W. L. Tai; Andrei A. Korostelev; Guangping Gao

    Recombinant adeno-associated viruses (rAAVs) are currently considered the safest and most reliable gene delivery vehicles for human gene therapy. Three serotype capsids, AAV1, AAV2, and AAV9, have been approved for commercial use in patients, but they may not be suitable for all therapeutic contexts. Here, we describe a novel capsid identified in a human clinical sample by high-throughput, long-read

    更新日期:2020-06-30
  • Reductive dearomative arylcarboxylation of indoles with CO 2 via visible-light photoredox catalysis
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Wen-Jun Zhou; Zhe-Hao Wang; Li-Li Liao; Yuan-Xu Jiang; Ke-Gong Cao; Tao Ju; Yiwen Li; Guang-Mei Cao; Da-Gang Yu

    Catalytic reductive coupling of two electrophiles and one unsaturated bond represents an economic and efficient way to construct complex skeletons, which is dominated by transition-metal catalysis via two electron transfer. Herein, we report a strategy of visible-light photoredox-catalyzed successive single electron transfer, realizing dearomative arylcarboxylation of indoles with CO2. This strategy

    更新日期:2020-06-29
  • On-chip coherent microwave-to-optical transduction mediated by ytterbium in YVO 4
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    John G. Bartholomew; Jake Rochman; Tian Xie; Jonathan M. Kindem; Andrei Ruskuc; Ioana Craiciu; Mi Lei; Andrei Faraon

    Optical networks that distribute entanglement among various quantum systems will form a powerful framework for quantum science but are yet to interface with leading quantum hardware such as superconducting qubits. Consequently, these systems remain isolated because microwave links at room temperature are noisy and lossy. Building long distance connectivity requires interfaces that map quantum information

    更新日期:2020-06-29
  • Tailored elastic surface to body wave Umklapp conversion
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Gregory J. Chaplain; Jacopo M. De Ponti; Andrea Colombi; Rafael Fuentes-Dominguez; Paul Dryburg; Don Pieris; Richard J. Smith; Adam Clare; Matt Clark; Richard V. Craster

    Elastic waves guided along surfaces dominate applications in geophysics, ultrasonic inspection, mechanical vibration, and surface acoustic wave devices; precise manipulation of surface Rayleigh waves and their coupling with polarised body waves presents a challenge that offers to unlock the flexibility in wave transport required for efficient energy harvesting and vibration mitigation devices. We design

    更新日期:2020-06-29
  • Long-term culture of human pancreatic slices as a model to study real-time islet regeneration
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Mirza Muhammad Fahd Qadir; Silvia Álvarez-Cubela; Jonathan Weitz; Julia K. Panzer; Dagmar Klein; Yaisa Moreno-Hernández; Sirlene Cechin; Alejandro Tamayo; Joana Almaça; Helmut Hiller; Maria Beery; Irina Kusmartseva; Mark Atkinson; Stephan Speier; Camillo Ricordi; Alberto Pugliese; Alejandro Caicedo; Christopher A. Fraker; Ricardo Luis Pastori; Juan Domínguez-Bendala

    The culture of live pancreatic tissue slices is a powerful tool for the interrogation of physiology and pathology in an in vitro setting that retains near-intact cytoarchitecture. However, current culture conditions for human pancreatic slices (HPSs) have only been tested for short-term applications, which are not permissive for the long-term, longitudinal study of pancreatic endocrine regeneration

    更新日期:2020-06-29
  • Inverse iron oxide/metal catalysts from galvanic replacement
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Yifeng Zhu; Xin Zhang; Katherine Koh; Libor Kovarik; John L. Fulton; Kevin M. Rosso; Oliver Y. Gutiérrez

    Key chemical transformations require metal and redox sites in proximity at interfaces; however, in traditional oxide-supported materials, this requirement is met only at the perimeters of metal nanoparticles. We report that galvanic replacement can produce inverse FeOx/metal nanostructures in which the concentration of oxide species adjoining metal domains is maximal. The synthesis involves reductive

    更新日期:2020-06-29
  • Quantifying molecular bias in DNA data storage
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Yuan-Jyue Chen; Christopher N. Takahashi; Lee Organick; Callista Bee; Siena Dumas Ang; Patrick Weiss; Bill Peck; Georg Seelig; Luis Ceze; Karin Strauss

    DNA has recently emerged as an attractive medium for archival data storage. Recent work has demonstrated proof-of-principle prototype systems; however, very uneven (biased) sequencing coverage has been reported, which indicates inefficiencies in the storage process. Deviations from the average coverage in the sequence copy distribution can either cause wasteful provisioning in sequencing or excessive

    更新日期:2020-06-29
  • Tumor invasion in draining lymph nodes is associated with Treg accumulation in breast cancer patients
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Nicolas Gonzalo Núñez; Jimena Tosello Boari; Rodrigo Nalio Ramos; Wilfrid Richer; Nicolas Cagnard; Cyrill Dimitri Anderfuhren; Leticia Laura Niborski; Jeremy Bigot; Didier Meseure; Philippe De La Rochere; Maud Milder; Sophie Viel; Delphine Loirat; Louis Pérol; Anne Vincent-Salomon; Xavier Sastre-Garau; Becher Burkhard; Christine Sedlik; Olivier Lantz; Sebastian Amigorena; Eliane Piaggio

    Tumor-draining lymph node (TDLN) invasion by metastatic cells in breast cancer correlates with poor prognosis and is associated with local immunosuppression, which can be partly mediated by regulatory T cells (Tregs). Here, we study Tregs from matched tumor-invaded and non-invaded TDLNs, and breast tumors. We observe that Treg frequencies increase with nodal invasion, and that Tregs express higher

    更新日期:2020-06-29
  • MetaRibo-Seq measures translation in microbiomes
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Brayon J. Fremin; Hila Sberro; Ami S. Bhatt

    No method exists to measure large-scale translation of genes in uncultured organisms in microbiomes. To overcome this limitation, we develop MetaRibo-Seq, a method for simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples. MetaRibo-Seq was benchmarked against gold-standard Ribo-Seq in a mock microbial community and applied to five different human fecal samples. Unlike

    更新日期:2020-06-29
  • Iron imaging in myocardial infarction reperfusion injury
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Brianna F. Moon; Srikant Kamesh Iyer; Eileen Hwuang; Michael P. Solomon; Anya T. Hall; Rishabh Kumar; Nicholas J. Josselyn; Elizabeth M. Higbee-Dempsey; Andrew Tsourkas; Akito Imai; Keitaro Okamoto; Yoshiaki Saito; James J. Pilla; Joseph H. Gorman; Robert C. Gorman; Cory Tschabrunn; Samuel J. Keeney; Estibaliz Castillero; Giovanni Ferrari; Steffen Jockusch; Felix W. Wehrli; Haochang Shou; Victor A

    Restoration of coronary blood flow after a heart attack can cause reperfusion injury potentially leading to impaired cardiac function, adverse tissue remodeling and heart failure. Iron is an essential biometal that may have a pathologic role in this process. There is a clinical need for a precise noninvasive method to detect iron for risk stratification of patients and therapy evaluation. Here, we

    更新日期:2020-06-29
  • Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-29
    Aobo Huang; Yu Tang; Xuetao Shi; Min Jia; Jinheng Zhu; Xiaohan Yan; Huiqin Chen; Yangnan Gu

    The inner nuclear membrane (INM) selectively accumulates proteins that are essential for nuclear functions; however, overaccumulation of INM proteins results in a range of rare genetic disorders. So far, little is known about how defective, mislocalized, or abnormally accumulated membrane proteins are actively removed from the INM, especially in plants and animals. Here, via analysis of a proximity-labeling

    更新日期:2020-06-29
  • Cobalt-catalyzed highly enantioselective hydrogenation of α,β-unsaturated carboxylic acids
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Xiaoyong Du; Ye Xiao; Jia-Ming Huang; Yao Zhang; Ya-Nan Duan; Heng Wang; Chuan Shi; Gen-Qiang Chen; Xumu Zhang

    Asymmetric hydrogenation of α,β-unsaturated acids catalyzed by noble metals has been well established, whereas, the asymmetric hydrogenation with earth-abundant-metal was rarely reported. Here, we describe a cobalt-catalyzed asymmetric hydrogenation of α,β-unsaturated carboxylic acids. By using chiral cobalt catalyst bearing electron-donating diphosphine ligand, high activity (up to 1860 TON) and excellent

    更新日期:2020-06-26
  • Acoustic spin-Chern insulator induced by synthetic spin–orbit coupling with spin conservation breaking
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Weiyin Deng; Xueqin Huang; Jiuyang Lu; Valerio Peri; Feng Li; Sebastian D. Huber; Zhengyou Liu

    Topologically protected surface modes of classical waves hold the promise to enable a variety of applications ranging from robust transport of energy to reliable information processing networks. However, both the route of implementing an analogue of the quantum Hall effect as well as the quantum spin Hall effect are obstructed for acoustics by the requirement of a magnetic field, or the presence of

    更新日期:2020-06-26
  • Breast cancer colonization by Fusobacterium nucleatum accelerates tumor growth and metastatic progression
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Lishay Parhi; Tamar Alon-Maimon; Asaf Sol; Deborah Nejman; Amjad Shhadeh; Tanya Fainsod-Levi; Olga Yajuk; Batya Isaacson; Jawad Abed; Naseem Maalouf; Aviram Nissan; Judith Sandbank; Einav Yehuda-Shnaidman; Falk Ponath; Jörg Vogel; Ofer Mandelboim; Zvi Granot; Ravid Straussman; Gilad Bachrach

    Fusobacterium nucleatum is an oral anaerobe recently found to be prevalent in human colorectal cancer (CRC) where it is associated with poor treatment outcome. In mice, hematogenous F. nucleatum can colonize CRC tissue using its lectin Fap2, which attaches to tumor-displayed Gal-GalNAc. Here, we show that Gal-GalNAc levels increase as human breast cancer progresses, and that occurrence of F. nucleatum

    更新日期:2020-06-26
  • An alkaloid initiates phosphodiesterase 3A–schlafen 12 dependent apoptosis without affecting the phosphodiesterase activity
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Youwei Ai; Haibing He; Peihao Chen; Bo Yan; Wenbin Zhang; Zhangcheng Ding; Dianrong Li; Jie Chen; Yan Ma; Yang Cao; Jie Zhu; Jiaojiao Li; Jinjie Ou; Shan Du; Xiaodong Wang; Jianzhang Ma; Shuanhu Gao; Xiangbing Qi

    The promotion of apoptosis in tumor cells is a popular strategy for developing anti-cancer drugs. Here, we demonstrate that the plant indole alkaloid natural product nauclefine induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway. Nauclefine binds PDE3A but does not inhibit the PDE3A’s phosphodiesterase activity, thus representing a previously unknown type of PDE3A modulator

    更新日期:2020-06-26
  • Dynamic perceptual feature selectivity in primary somatosensory cortex upon reversal learning
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Ronan Chéreau; Tanika Bawa; Leon Fodoulian; Alan Carleton; Stéphane Pagès; Anthony Holtmaat

    Neurons in primary sensory cortex encode a variety of stimulus features upon perceptual learning. However, it is unclear whether the acquired stimulus selectivity remains stable when the same input is perceived in a different context. Here, we monitor the activity of individual neurons in the mouse primary somatosensory cortex during reward-based texture discrimination. We track their stimulus selectivity

    更新日期:2020-06-26
  • NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Kai Miao; Josh Haipeng Lei; Monica Vishnu Valecha; Aiping Zhang; Jun Xu; Lijian Wang; Xueying Lyu; Si Chen; Zhengqiang Miao; Xin Zhang; Sek Man Su; Fangyuan Shao; Barani Kumar Rajendran; Jiaolin Bao; Jianming Zeng; Heng Sun; Ping Chen; Kaeling Tan; Qiang Chen; Koon Ho Wong; Xiaoling Xu; Chu-Xia Deng

    BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer drivers, among which Notch1 is a top candidate for accelerating TNBC by promoting the epithelial-mesenchymal

    更新日期:2020-06-26
  • Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Tuo Wei; Qiang Cheng; Yi-Li Min; Eric N. Olson; Daniel J. Siegwart

    CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic targets cannot currently be accessed due to the lack of carriers that can deliver RNPs systemically. Here, we report a generalizable methodology that allows engineering of modified lipid nanoparticles to efficiently deliver RNPs into cells and

    更新日期:2020-06-26
  • The receptor PTPRU is a redox sensitive pseudophosphatase
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Iain M. Hay; Gareth W. Fearnley; Pablo Rios; Maja Köhn; Hayley J. Sharpe; Janet E. Deane

    The receptor-linked protein tyrosine phosphatases (RPTPs) are key regulators of cell-cell communication through the control of cellular phosphotyrosine levels. Most human RPTPs possess an extracellular receptor domain and tandem intracellular phosphatase domains: comprising an active membrane proximal (D1) domain and an inactive distal (D2) pseudophosphatase domain. Here we demonstrate that PTPRU is

    更新日期:2020-06-26
  • Rationally designed ruthenium complexes for 1- and 2-photon photodynamic therapy
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Johannes Karges; Shi Kuang; Federica Maschietto; Olivier Blacque; Ilaria Ciofini; Hui Chao; Gilles Gasser

    The use of photodynamic therapy (PDT) against cancer has received increasing attention over recent years. However, the application of the currently approved photosensitizers (PSs) is limited by their poor aqueous solubility, aggregation, photobleaching and slow clearance from the body. To overcome these limitations, there is a need for the development of new classes of PSs with ruthenium(II) polypyridine

    更新日期:2020-06-26
  • Tracking down the molecular architecture of the synaptonemal complex by expansion microscopy
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Fabian U. Zwettler; Marie-Christin Spindler; Sebastian Reinhard; Teresa Klein; Andreas Kurz; Ricardo Benavente; Markus Sauer

    The synaptonemal complex (SC) is a meiosis-specific nuclear multiprotein complex that is essential for proper synapsis, recombination and segregation of homologous chromosomes. We combined structured illumination microscopy (SIM) with different expansion microscopy (ExM) protocols including U-ExM, proExM, and magnified analysis of the proteome (MAP) to investigate the molecular organization of the

    更新日期:2020-06-26
  • Selective ion sensing with high resolution large area graphene field effect transistor arrays
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Ibrahim Fakih; Oliver Durnan; Farzaneh Mahvash; Ilargi Napal; Alba Centeno; Amaia Zurutuza; Viviane Yargeau; Thomas Szkopek

    Real-time, high resolution, simultaneous measurement of multiple ionic species is challenging with existing chromatographic, spectrophotometric and potentiometric techniques. Potentiometric ion sensors exhibit limitations in both resolution and selectivity. Herein, we develop wafer scale graphene transistor technology for overcoming these limitations. Large area graphene is an ideal material for high

    更新日期:2020-06-26
  • Fishing for newly synthesized proteins with phosphonate-handles
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Fleur Kleinpenning; Barbara Steigenberger; Wei Wu; Albert J. R. Heck

    Bioorthogonal chemistry introduces affinity-labels into biomolecules with minimal disruption to the original system and is widely applicable in a range of contexts. In proteomics, immobilized metal affinity chromatography (IMAC) enables enrichment of phosphopeptides with extreme sensitivity and selectivity. Here, we adapt and combine these superb assets in a new enrichment strategy using phosphonate-handles

    更新日期:2020-06-26
  • Closed-loop atomic force microscopy-infrared spectroscopic imaging for nanoscale molecular characterization
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Seth Kenkel; Shachi Mittal; Rohit Bhargava

    Atomic force microscopy-infrared (AFM-IR) spectroscopic imaging offers non-perturbative, molecular contrast for nanoscale characterization. The need to mitigate measurement artifacts and enhance sensitivity, however, requires narrowly-defined and strict sample preparation protocols. This limits reliable and facile characterization; for example, when using common substrates such as Silicon or glass

    更新日期:2020-06-26
  • Exploiting metabolic acidosis in solid cancers using a tumor-agnostic pH-activatable nanoprobe for fluorescence-guided surgery
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    F. J. Voskuil; P. J. Steinkamp; T. Zhao; B. van der Vegt; M. Koller; J. J. Doff; Y. Jayalakshmi; J. P. Hartung; J. Gao; B. D. Sumer; M. J. H. Witjes; G. M. van Dam

    Cancer cell metabolism leads to a uniquely acidic microenvironment in solid tumors, but exploiting the labile extracellular pH differences between cancer and normal tissues for clinical use has been challenging. Here we describe the clinical translation of ONM-100, a nanoparticle-based fluorescent imaging agent. This is comprised of an ultra-pH sensitive amphiphilic polymer, conjugated with indocyanine

    更新日期:2020-06-26
  • Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Yubin Guo; Qing Ye; Pan Deng; Yanan Cao; Daheng He; Zhaohe Zhou; Chi Wang; Yekaterina Y. Zaytseva; Charles E. Schwartz; Eun Y. Lee; B. Mark Evers; Andrew J. Morris; Side Liu; Qing-Bai She

    Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer (CRC), but the underlying mechanism is incompletely characterized. Here, we report that spermine synthase (SMS), a polyamine biosynthetic enzyme, is overexpressed in CRC. Targeted disruption of SMS in CRC cells results in spermidine accumulation, which inhibits FOXO3a acetylation and allows subsequent translocation

    更新日期:2020-06-26
  • Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    M. Catarina Silva; Ghata A. Nandi; Sharon Tentarelli; Ian K. Gurrell; Tanguy Jamier; Diane Lucente; Bradford C. Dickerson; Dean G. Brown; Nicholas J. Brandon; Stephen J. Haggarty

    Tauopathies are neurodegenerative diseases associated with accumulation of abnormal tau protein in the brain. Patient iPSC-derived neuronal cell models replicate disease-relevant phenotypes ex vivo that can be pharmacologically targeted for drug discovery. Here, we explored autophagy as a mechanism to reduce tau burden in human neurons and, from a small-molecule screen, identify the mTOR inhibitors

    更新日期:2020-06-26
  • A potent KRAS macromolecule degrader specifically targeting tumours with mutant KRAS
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Nicolas Bery; Ami Miller; Terry Rabbitts

    Tumour-associated KRAS mutations are the most prevalent in the three RAS-family isoforms and involve many different amino-acids. Therefore, molecules able to interfere with mutant KRAS protein are potentially important for wide-ranging tumour therapy. We describe the engineering of two RAS degraders based on protein macromolecules (macrodrugs) fused to specific E3 ligases. A KRAS-specific DARPin fused

    更新日期:2020-06-26
  • Ultrafast diffusion exchange nuclear magnetic resonance
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Otto Mankinen; Vladimir V. Zhivonitko; Anne Selent; Sarah Mailhiot; Sanna Komulainen; Nønne L. Prisle; Susanna Ahola; Ville-Veikko Telkki

    The exchange of molecules between different physical or chemical environments due to diffusion or chemical transformations has a crucial role in a plethora of fundamental processes such as breathing, protein folding, chemical reactions and catalysis. Here, we introduce a method for a single-scan, ultrafast NMR analysis of molecular exchange based on the diffusion coefficient contrast. The method shortens

    更新日期:2020-06-26
  • Uncovering the effects of interface-induced ordering of liquid on crystal growth using machine learning
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Rodrigo Freitas; Evan J. Reed

    The process of crystallization is often understood in terms of the fundamental microstructural elements of the crystallite being formed, such as surface orientation or the presence of defects. Considerably less is known about the role of the liquid structure on the kinetics of crystal growth. Here atomistic simulations and machine learning methods are employed together to demonstrate that the liquid

    更新日期:2020-06-26
  • Cavity piezo-mechanics for superconducting-nanophotonic quantum interface
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Xu Han; Wei Fu; Changchun Zhong; Chang-Ling Zou; Yuntao Xu; Ayed Al Sayem; Mingrui Xu; Sihao Wang; Risheng Cheng; Liang Jiang; Hong X. Tang

    Hybrid quantum systems are essential for the realization of distributed quantum networks. In particular, piezo-mechanics operating at typical superconducting qubit frequencies features low thermal excitations, and offers an appealing platform to bridge superconducting quantum processors and optical telecommunication channels. However, integrating superconducting and optomechanical elements at cryogenic

    更新日期:2020-06-26
  • Epigenetic regulation of spurious transcription initiation in Arabidopsis
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Ngoc Tu Le; Yoshiko Harukawa; Saori Miura; Damian Boer; Akira Kawabe; Hidetoshi Saze

    In plants, epigenetic regulation is critical for silencing transposons and maintaining proper gene expression. However, its impact on the genome-wide transcription initiation landscape remains elusive. By conducting a genome-wide analysis of transcription start sites (TSSs) using cap analysis of gene expression (CAGE) sequencing, we show that thousands of TSSs are exclusively activated in various epigenetic

    更新日期:2020-06-26
  • Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Loïc Carrique; Lionel Ballut; Arpit Shukla; Neelakshi Varma; Resmi Ravi; Sébastien Violot; Bharath Srinivasan; Umesh Tippagondanahalli Ganeshappa; Sonia Kulkarni; Hemalatha Balaram; Nushin Aghajari

    Plasmodium falciparum (Pf) relies solely on the salvage pathway for its purine nucleotide requirements, making this pathway indispensable to the parasite. Purine nucleotide levels are regulated by anabolic processes and by nucleotidases that hydrolyse these metabolites into nucleosides. Certain apicomplexan parasites, including Pf, have an IMP-specific-nucleotidase 1 (ISN1). Here we show, by comprehensive

    更新日期:2020-06-26
  • Focus on the spectra that matter by clustering of quantification data in shotgun proteomics
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Matthew The; Lukas Käll

    In shotgun proteomics, the analysis of label-free quantification experiments is typically limited by the identification rate and the noise level in the quantitative data. This generally causes a low sensitivity in differential expression analysis. Here, we propose a quantification-first approach for peptides that reverses the classical identification-first workflow, thereby preventing valuable information

    更新日期:2020-06-26
  • Kinetics of motile solitons in nematic liquid crystals
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Satoshi Aya; Fumito Araoka

    The generation of spatially localized, soliton-like hydrodynamic disturbances in microscale fluidic systems is an intriguing challenge. Herein, we introduce nonequilibrium solitons in nematic liquid crystals stimulated by an electric field. These dynamic solitons are robust as long as the electric field is maintained. Interestingly, their kinetic behaviours depend on the field condition—Tuning of the

    更新日期:2020-06-26
  • In planta study of photosynthesis and photorespiration using NADPH and NADH/NAD + fluorescent protein sensors
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Shey-Li Lim; Chia Pao Voon; Xiaoqian Guan; Yi Yang; Per Gardeström; Boon Leong Lim

    The challenge of monitoring in planta dynamic changes of NADP(H) and NAD(H) redox states at the subcellular level is considered a major obstacle in plant bioenergetics studies. Here, we introduced two circularly permuted yellow fluorescent protein sensors, iNAP and SoNar, into Arabidopsis thaliana to monitor the dynamic changes in NADPH and the NADH/NAD+ ratio. In the light, photosynthesis and photorespiration

    更新日期:2020-06-26
  • Forelimb movements evoked by optogenetic stimulation of the macaque motor cortex
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Hidenori Watanabe; Hiromi Sano; Satomi Chiken; Kenta Kobayashi; Yuko Fukata; Masaki Fukata; Hajime Mushiake; Atsushi Nambu

    Optogenetics has become an indispensable tool for investigating brain functions. Although non-human primates are particularly useful models for understanding the functions and dysfunctions of the human brain, application of optogenetics to non-human primates is still limited. In the present study, we generate an effective adeno-associated viral vector serotype DJ to express channelrhodopsin-2 (ChR2)

    更新日期:2020-06-26
  • Coastal sedimentation across North America doubled in the 20 th century despite river dams
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    A. B. Rodriguez; B. A. McKee; C. B. Miller; M. C. Bost; A. N. Atencio

    The proliferation of dams since 1950 promoted sediment deposition in reservoirs, which is thought to be starving the coast of sediment and decreasing the resilience of communities to storms and sea-level rise. Diminished river loads measured upstream from the coast, however, should not be assumed to propagate seaward. Here, we show that century-long records of sediment mass accumulation rates (g cm−2 yr−1)

    更新日期:2020-06-26
  • Reduced neural selectivity for mental states in deaf children with delayed exposure to sign language
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Hilary Richardson; Jorie Koster-Hale; Naomi Caselli; Rachel Magid; Rachel Benedict; Halie Olson; Jennie Pyers; Rebecca Saxe

    Language provides a rich source of information about other people’s thoughts and feelings. Consequently, delayed access to language may influence conceptual development in Theory of Mind (ToM). We use functional magnetic resonance imaging and behavioral tasks to study ToM development in child (n = 33, 4–12 years old) and adult (n = 36) fluent signers of American Sign Language (ASL), and characterize

    更新日期:2020-06-26
  • The dynamics of overlayer formation on catalyst nanoparticles and strong metal-support interaction
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Arik Beck; Xing Huang; Luca Artiglia; Maxim Zabilskiy; Xing Wang; Przemyslaw Rzepka; Dennis Palagin; Marc-Georg Willinger; Jeroen A. van Bokhoven

    Heterogeneous catalysts play a pivotal role in the chemical industry. The strong metal-support interaction (SMSI), which affects the catalytic activity, is a phenomenon researched for decades. However, detailed mechanistic understanding on real catalytic systems is lacking. Here, this surface phenomenon was studied on an actual platinum-titania catalyst by state-of-the-art in situ electron microscopy

    更新日期:2020-06-26
  • Electromagnetic character of the competitive γ γ / γ -decay from 137m Ba
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    P.-A. Söderström; L. Capponi; E. Açıksöz; T. Otsuka; N. Tsoneva; Y. Tsunoda; D. L. Balabanski; N. Pietralla; G. L. Guardo; D. Lattuada; H. Lenske; C. Matei; D. Nichita; A. Pappalardo; T. Petruse

    Second-order processes in physics is a research topic focusing attention from several fields worldwide including, for example, non-linear quantum electrodynamics with high-power lasers, neutrinoless double-β decay, and stimulated atomic two-photon transitions. For the electromagnetic nuclear interaction, the observation of the competitive double-γ decay from 137mBa has opened up the nuclear structure

    更新日期:2020-06-26
  • miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Matthew Knarr; Rita A. Avelar; Sreeja C. Sekhar; Lily J. Kwiatkowski; Michele L. Dziubinski; Jessica McAnulty; Stephanie Skala; Stefanie Avril; Ronny Drapkin; Analisa DiFeo

    Genomic instability (GI) predisposes cells to malignant transformation, however the molecular mechanisms that allow for the propagation of cells with a high degree of genomic instability remain unclear. Here we report that miR-181a is able to transform fallopian tube secretory epithelial cells through the inhibition of RB1 and stimulator-of-interferon-genes (STING) to propagate cells with a high degree

    更新日期:2020-06-26
  • Representation of molecular structures with persistent homology for machine learning applications in chemistry
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Jacob Townsend; Cassie Putman Micucci; John H. Hymel; Vasileios Maroulas; Konstantinos D. Vogiatzis

    Machine learning and high-throughput computational screening have been valuable tools in accelerated first-principles screening for the discovery of the next generation of functionalized molecules and materials. The application of machine learning for chemical applications requires the conversion of molecular structures to a machine-readable format known as a molecular representation. The choice of

    更新日期:2020-06-26
  • Genetic drug target validation using Mendelian randomisation
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Amand F. Schmidt; Chris Finan; Maria Gordillo-Marañón; Folkert W. Asselbergs; Daniel F. Freitag; Riyaz S. Patel; Benoît Tyl; Sandesh Chopade; Rupert Faraway; Magdalena Zwierzyna; Aroon D. Hingorani

    Mendelian randomisation (MR) analysis is an important tool to elucidate the causal relevance of environmental and biological risk factors for disease. However, causal inference is undermined if genetic variants used to instrument a risk factor also influence alternative disease-pathways (horizontal pleiotropy). Here we report how the ‘no horizontal pleiotropy assumption’ is strengthened when proteins

    更新日期:2020-06-26
  • Turning induced plasticity into refined adaptations during range expansion
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Ahva L. Potticary; Erin S. Morrison; Alexander V. Badyaev

    Robustness against environmental fluctuations within an adaptive state should preclude exploration of new adaptive states when the environment changes. Here, we study transitions between adaptive associations of feather structure and carotenoid uptake to understand how robustness and evolvability can be reconciled. We show that feather modifications induced by unfamiliar carotenoids during a range

    更新日期:2020-06-26
  • Employing a MEMS plasma switch for conditioning high-voltage kinetic energy harvesters
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Hemin Zhang; Frédéric Marty; Xin Xia; Yunlong Zi; Tarik Bourouina; Dimitri Galayko; Philippe Basset

    Triboelectric nanogenerators have attracted wide attention due to their promising capabilities of scavenging the ambient environmental mechanical energy. However, efficient energy management of the generated high-voltage for practical low-voltage applications is still under investigation. Autonomous switches are key elements for improving the harvested energy per mechanical cycle, but they are complicated

    更新日期:2020-06-26
  • Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Joshua C. Worch; Andrew C. Weems; Jiayi Yu; Maria C. Arno; Thomas R. Wilks; Robert T. R. Huckstepp; Rachel K. O’Reilly; Matthew L. Becker; Andrew P. Dove

    Biocompatible polymers are widely used in tissue engineering and biomedical device applications. However, few biomaterials are suitable for use as long-term implants and these examples usually possess limited property scope, can be difficult to process, and are non-responsive to external stimuli. Here, we report a class of easily processable polyamides with stereocontrolled mechanical properties and

    更新日期:2020-06-26
  • Groundwater level observations in 250,000 coastal US wells reveal scope of potential seawater intrusion
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Scott Jasechko; Debra Perrone; Hansjörg Seybold; Ying Fan; James W. Kirchner

    Seawater intrusion into coastal aquifers can increase groundwater salinity beyond potable levels, endangering access to freshwater for millions of people. Seawater intrusion is particularly likely where water tables lie below sea level, but can also arise from groundwater pumping in some coastal aquifers with water tables above sea level. Nevertheless, no nation-wide, observation-based assessment of

    更新日期:2020-06-26
  • Protein arginine deiminase 4 antagonizes methylglyoxal-induced histone glycation
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Qingfei Zheng; Adewola Osunsade; Yael David

    Protein arginine deiminase 4 (PAD4) facilitates the post-translational citrullination of the core histones H3 and H4. While the precise epigenetic function of this modification has not been resolved, it has been shown to associate with general chromatin decompaction and compete with arginine methylation. Recently, we found that histones are subjected to methylglyoxal (MGO)-induced glycation on nucleophilic

    更新日期:2020-06-26
  • Twelve-year clinical trajectories of multimorbidity in a population of older adults
    Nat. Commun. (IF 12.121) Pub Date : 2020-06-26
    Davide L. Vetrano; Albert Roso-Llorach; Sergio Fernández; Marina Guisado-Clavero; Concepción Violán; Graziano Onder; Laura Fratiglioni; Amaia Calderón-Larrañaga; Alessandra Marengoni

    Multimorbidity—the co-occurrence of multiple diseases—is associated to poor prognosis, but the scarce knowledge of its development over time hampers the effectiveness of clinical interventions. Here we identify multimorbidity clusters, trace their evolution in older adults, and detect the clinical trajectories and mortality of single individuals as they move among clusters over 12 years. By means of

    更新日期:2020-06-26
Contents have been reproduced by permission of the publishers.
导出
全部期刊列表>>
胸部和胸部成像专题
自然科研论文编辑服务
ACS ES&T Engineering
ACS ES&T Water
屿渡论文,编辑服务
鲁照永
华东师范大学
苏州大学
南京工业大学
南开大学
中科大
唐勇
跟Nature、Science文章学绘图
隐藏1h前已浏览文章
中洪博元
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
x-mol收录
广东实验室
南京大学
王杰
南科大
刘尊峰
湖南大学
清华大学
王小野
中山大学化学工程与技术学院
试剂库存
天合科研
down
wechat
bug