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Direct Solution of u″=f(t,u,u′) Using Three Point Block Method of Order Eight with Applications J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-07 Reem Allogmany; Fudziah Ismail
This study aims to construct an implicit block method with three-point to tackle general second-order ordinary differential equations (ODEs) directly. Hermite Interpolating Polynomial is used as the fundamental function to obtain the proposed method which involved the first and second derivatives of f(t,u,u′). From the investigation done, it was found that the proposed method is consistent and zero-stable
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Schiff base ligand L synthesis and its evaluation as anticancer and antidepressant agent J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-30 Maria Sadia; Jehangir Khan; RobinaNaz; Muhammad Zahoor; Syed Wadood Ali Shah; Riaz Ullah; Sumaira Naz; Ahmed Bari; Hafiz Majid Mahmood; Syed Saeed Ali; Muhammad Sohaib; Saddique A. Ansari
Objectives The current study focuses on the synthesis of Schiff base ligand L [1(pyridine-2-ylimino) methyl) naphthalene-2-ol], and its applications as anticancer agent against human lung (H-460) and breast (MCF-7) cell lines, and as antidepressant agent. Methods The Schiff base ligand L was synthesized by aldol condensation reaction by reacting commercially available 2-hydroxy-1-napthaldehyde with
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An efficient approach for fractional nonlinear chaotic model with Mittag-Leffler law J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-21 P. Veeresha; D.G. Prakasha; Abdel-Haleem Abdel-Aty; Harendra Singh; Emad E. Mahmoud; Sunil Kumar
In this work, we exemplify the behaviour of the nonlinear model of arbitrary order differential equations by adopting q-homotopy analysis transform method (q-HATM). In the present study, the illustrated scheme is a graceful amalgamation of Laplace transform with q-homotopy analysis algorithm and we considered arbitrary order derivative using Atangana-Baleanu (AB) operator. The suggested nonlinear system
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Enhanced production of camptothecin by immobilized callus of Ophiorrhiza mungos and a bioinformatic insight into its potential antiviral effect against SARS-CoV-2 J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-21 Rajesh Mamkulatil Devasia; Mohammad Altaf; Abdulwahed Fahad Alrefaei; Salim Manoharadas
Camptothetin (CPT) is a quinoline alkaloid originally isolated from the Chinese tree, Camptotheca acuminata Decne. CPT was found to have anticancerous and antiviral properties. Derivatives of natural CPT, including toptecan and irinotecan are used clinically to treat a variety of cancers. Apart from Camptotheca acuminata Decne, CPT production was also found in the perennial plant Ophiorrhiza mungos
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Sinc and B-Spline scaling functions for time-fractional convection-diffusion equations J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-21 Leila Adibmanesha; Jalil Rashidiniab
We study combination of Sinc and B-Spline scaling functions to develop numerical method for the time-fractional convection-diffusion equations . Dou to exponential convergence of Sinc interpolation, the shifted Sinc functions based on double exponential transformation have been used for the spatial discretization , and the B-Spline scaling functions have been used for the temporal discretization. We
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Derivation of Fractional-Derivative Models of Multiphase Fluid Flows in Porous Media J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-21 Mohamed F. El-Amin
This paper is devoted to deriving several fractional-order models for multiphase flows in porous media, focusing on some special cases of the two-phase flow. We derive the mass and momentum conservation laws of multiphase flow in porous media. The mass conservation-law has been developed based on the flux variation using Taylor series approximation. The fractional Taylor series's advantage is that
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Biological and therapeutic roles of Saudi Arabian honey: A comparative review J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-30 Ahmad A. Al-Ghamdi; Mohammad Javed Ansari
Honey is deeply rooted in Saudi Arabian culture, religion, and trade, and The Holy Quran refers to its medicinal and healing properties several times. Honey is a highly symbolic and well-regarded product in the Kingdom of Saudi Arabia and it is widely used for its medicinal value in addition to its nutritional uses. Saudi Arabia is home to an estimated 2200 flowering plants, and monofloral honey from
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Modeling Cyclic Volatile Methylsiloxanes Removal Efficiency from Wastewater by ZnO-coated Aluminum anode using Artificial Neural Networks J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-07 B.S. Reddy; P.L Narayana; A.K. Maurya; V. Gupta; Y.H. Reddy; Abdulwahed F. Alrefaei; Hussein H. Alkhamis; Kwon-Koo Cho; N.S. Reddy
Usage of cyclic volatile methyl siloxanes(cVMSs) in the industrial process is unavoidable due to their superior properties; however, it is hazardous to human health. Photocatalytic zinc oxide coated aluminum anode is used to degrade the cVMSs in wastewater. In this work, we investigated the relationship among degradation process parameters such as current density(4 - 20 mA/cm2), initial pH(5 -9), plate
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A reliable numerical method for solving fractional reaction-diffusion equations J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-29 Supriya Yadav; Devendra Kumar; Kottakkaran Sooppy Nisar
The present work aims to solve the fractional reaction–diffusion equation (RDE) using an effective and powerful hybrid analytical scheme, namely q-HASTM. The suggested technique is the combination of Sumudu transform (ST) and HAM technique. The definition of Caputo's fractional derivative has used. The numerical procedure reveals that only few iterations are needed for better approximation of the solution
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Relationship between precursory signals and corresponding earthquakes using different spectral analysis techniques J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-07 Ghada Ali; Ali G. Hafez; El-Sayed Soliman A. Said; Kamal Abdelrahman; Elkhedr Ibrahim; Naif Alotaibi
The origin of precursory signals that precede the P-waves is controversial, as it may be caused by ground effect (seismic nucleation phase) or instrumental effect due to a digitizer. Such signals cause errors in the automatic detection of P-wave arrival times and consequently decrease the accuracy of earthquake parameter estimations. In this paper, we proposed spectral analysis techniques to distinguish
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Antioxidant and organic acid evaluation of Geaster saccatum mushroom by chemical and electrochemical assay at carbon nanotube paste electrode J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-07 Javed Ahmad Wagay; Amer M. Alanazi; Deepak Vyas; Shauket Ahmad Pala; Qazi Inamur Rahman
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Comparison of the SARS-CoV-2 (2019-nCoV) M protein with its counterparts of SARS-CoV and MERS-CoV species J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-07 Sultan Nafea Alharbi; Abdulwahed Fahad Alrefaei
Coronaviruses M proteins are well-represented in the major protein component of the viral envelope. During the viral assembly, they play an important role by association with all other viral structural proteins. Despite their crucial functions, very little information regarding the structures and functions of M proteins is available. Here we utilize bioinformatic tools from available sequences and
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Quantum chemical studies on molecular structure, AIM, ELF, RDG and antiviral activities of hybrid hydroxychloroquine in the treatment of COVID-19: Molecular docking and DFT calculations J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-06 Olfa Noureddine; Noureddine Issaoui; Mouna Medimagh; Omar Al-Dossary; Houda Marouani
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Anti-biofilm effect of Nerium oleander essential oils against biofilm forming Pseudomonas aeruginosa on urinary tract infections J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-14 Taghreed N. Almanaa; Naiyf S. Alharbi; Govindan Ramachandran; Chenthis Kanisha Chelliah; Govindan Rajivgandhi; Natesan Manoharan; Shine Kadaikunnan; Jamal M. Khaled; Khalid F. Alanzi
Based on the untreated biofilm formation in urinary tract infections (UTIs), current study was focused on the inhibition of Pseudomonas aeruginosa (P. aeruginosa) biofilm formation using Nerium oleander (N. oleander) essential oils. Initially, the LC-MS analysis of antibacterial potential of hydro distillated N. oleander essential oils was detected by LC-MS analysis. Initially, the antibacterial nature
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Elemental composition and physical characteristics of the massive meteorite of the Saudi Empty Quarter J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-14 M.S. AlSalhi; V. Masilamani; Nasser Alarifi; W. Aslam Farooq; M. Atif; Shahid Ramay; Hayat Saeed Althobaiti; Saqib Anwar; Ibrahim Elkhedr; Bassam A. Abuamarah
The meteorite found in the Empty Quarter of Kingdom of Saudi Arabia (KSA) is the largest meteorite found in the KSA and has the shape of an irregular ellipsoid with semi-axes of 0.65 m, 0.38 m, and 0.27 m; a density of 6400 kg/m3; and a mass of 2550 kg. It is a massive piece belonging to the category of iron–nickel meteorites, which is contained in only 5% of the total showers. The present report is
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Theoretical analysis of unstable segments of electrostatic spinning charged jet J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-31 Liang Zhiyong; Lu Li
The basic mechanism of electrospinning is the rapid whipping of charged liquid jets, undergoing a chaotic “whip” process, and eventually the formation of disordered reticular fibers is continuously deposited on the receiving device. Firstly, the physical model of jet whipping is studied, which is to be established the physical model of solvent evaporation on the surface of the jet. The Jeffreys model
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Antioxidant and anti-diabetic activities of bioactive fractions of Carica papaya seeds extract J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-13 Reuben Agada; Dluya Thagriki; D. Esther Lydia; Ameer Khusro; Jawaher Alkahtani; Manal M. Al Shaqha; Mona S. Alwahibi; Mohamed Soliman Elshikh
Carica papaya has tremendous medicinal applications against diverse diseases since ancient period. Considering this, the present study was aimed to assess in vitro antioxidant and anti-diabetic activities of bioactive fractions of C. papaya seed extracts. Initially, the shade-dried ripen seeds of C. papaya were powdered and extracted via soxhlet protocol to obtain crude extracts. The crude extracts
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Experimental and simulation investigations of CPV/TEG hybrid system J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-27 Mohamed Sabry; Abdelrahman Lashin; Mohammed Al Turkestani
Concentrator photovoltaic (CPV) technology is a leading approach for increasing the utilization and deployment of PV systems. A major disadvantage is the need for cooling to maintain the performance of the solar cell. Active cooling is power-consuming and complex. A proposed passive cooling subsystem, uses a thermoelectric generator (TEG), besides cooling the solar cell, it generates power from waste
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Structural, electrical and optical properties of Zn1−xCuxO (x = 0.00–0.09) nanoparticles J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-31 Tariq Munir; Arslan Mahmood; Naveed Ahmad; M. Atif; K.S. Alimgeer; Amanullah Fatehmulla; Atif Hanif; Nafeesah Yaqub; W.A. Farooq; Shafiq Ahmad; Yu-ming Chu; Hijaz Ahmad
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The cytotoxic and anti-inflammatory potential of Tetragonula sapiens propolis from Sulawesi on raw 264.7 cell lines J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-27 Muhamad Sahlan; Kaysa Faradis Mahira; Diah Kartika Pratami; Rizal Rizal; Mohammad Javed Ansari; Khalid Mashay Al-Anazi; Mohammad Abul Farah
Propolis is a naturally produced resinous mixture the bees are secreted through collecting resin of plants, buds, and exudates. According to several studies, propolis possessed various properties, one of which known as immunomodulatory property. Immunomodulatory property can be assessed and observed through the anti-inflammatory and cytotoxicity properties of propolis. In Indonesia, Tetragonula sapiens
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Omics-based approach in characterising mechanisms of entomopathogenic fungi pathogenicity: A case example of Beauveria bassiana J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-30 Nazmi Harith-Fadzilah; Idris Abd Ghani; Maizom Hassan
Biopesticides are gaining interests as an alternative to chemical-based pesticides for arthropod pest management. Among the widely-used biopesticides is the entomopathogenic fungi Beauveria bassiana due to its efficacy and broad range of arthropod hosts. Although the general mechanisms of infection by B. bassiana are known, the underlying complexity of molecular mechanisms at each infection stage is
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Biogenic synthesis, characterization and antimicrobial activity of Ixora brachypoda (DC) leaf extract mediated silver nanoparticles J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-24 Meghashyama Bhat; Bidhayak Chakraborty; Raju Suresh Kumar; Abdulrahman I. Almansour; Natarajan Arumugam; D. Kotresha; S.S. Pallavi; S.B. Dhanyakumara; K.N. Shashiraj; Sreenivasa Nayaka
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Biological and microbiological activities of isolated Enterobacter sp. ACD2 exopolysaccharides from Tabuk region of Saudi Arabia J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-30 Mikhlid H. Almutairi; Mohamed M.I. Helal
Several forms of bacterial exopolysaccharides (EPSs) have been reported as having industrial and medical benefits. Previously, our group had achieved a high yield of EPS production (8.6 gm/L) from Enterobacter sp. isolated from the marine environment of Haqel Beach, in the Tabuk region of Saudi Arabia, by optimizing its culture conditions. Then, the strain selected was identified using conventional
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Assessment of decadal land use dynamics of upper catchment area of Narmada River, the lifeline of Central India J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-29 Tarun Kumar Thakur; D.K. Patel; Joystu Dutta; Anirudh Kumar; Sandeep Kaushik; Arvind Bijalwan; Mohammed S. Fnais; Kamal Abdelrahman; Mohammad Javed Ansari
India is a land of rivers and Narmada is one of the principal river systems and is ascribed as the lifeline of Central India. Freshwater ecosystems such as rivers across the globe are facing degradation due to multitude of anthropogenic stress factors. Holistic and sustainable approach is prerequisite for monitoring, risk assessment and management of such multitude of problems and critical challenges
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Generalized non-integer Lennard-Jones potential function vs. generalized Morse potential function for calculating cohesive energy and melting point of nanoparticles J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-27 Omar M. Aldossary
A generalized non-integer Lennard-Jones (L-J) potential function with an additional parameter m is proposed to calculate the cohesive energy and melting point of nanoparticles. The model based on the new generalized non-integer L-J potential function has been successful in predicting experimental values. The calculated cohesive energies show an excellent agreement with the experimental values of the
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RBF collocation approach to calculate numerically the solution of the nonlinear system of qFDEs J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-18 Fahimeh Akhavan Ghassabzadeh; Emran Tohidi; Harendra Singh; Stanford Shateyi
In this paper, we have implemented an efficient and high accurate radial basis function (RBF) collocation scheme for solving nonlinear systems of q-fractional differential equations. We firstly convert the problems under investigation into the equivalent systems of weakly singular q-integral equations by some essential results of fractional q-calculus. Secondly, we combine RBF collocation method and
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Bifunctional electro-catalytic performances of NiMoO4-NRs@RGO nanocomposites for oxygen evolution and oxygen reduction reactions J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-26 Jahangeer Ahmed; Manawwer Alam; M.A. Majeed Khan; Saad M. Alshehri
In present study, we report hydrothermal synthesis of reduced graphene oxide (RGO) supported NiMoO4-nanorods (NRs) nanocomposites (NiMoO4-NRs@RGO nanocomposites) for electro-catalysis of water to oxygen evolution and reduction reactions (OER/ORR). The prepared nanocomposites were characterized by x-ray diffraction (XRD), Raman, Fourier transform infrared (FTIR), high resolution transmission electron
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Consumption of sage (Salvia officinalis) promotes ovarian function by stimulating estradiol hormone release and controlling folliculogenesis, steroidogenesis, and autophagy J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-26 Abdulkarem Alrezaki; Nouf Aldawood; Shamsa Alanazi; Maria Arafah; Zuzana Fabova; Yacine Badjah; Alexander V. Sirotkin; Saleh Alwasel; Abdel Halim Harrath
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Metal doped titania nanoparticles as efficient photocatalyst for dyes degradation J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-29 Maria Sadia; Robina Naz; Jehangir Khan; Muhammad Zahoor; Riaz Ullah; Rizwan Khan; Sumaira Naz; Hesham S. Almoallim; Sulaiman Ali Alharbi
Objectives: The present work aims at the synthesis of metal-doped and undoped titania photocatalysts for the degradation of methylene blue and neutral red dyes. Methods: Un-doped and metal-doped titania photocatalysts were synthesized by hydrothermal treatment, calcined at 673 K, and were evaluated by SEM, XRD, and XPS techniques for their phase composition. Results and conclusions: XPS studies of
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Explicit and traveling wave solutions of the non-linear couple Drinfeld-Sokolov-Wilson dynamical system arising in shallow water waves J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-19 Aly R. Seadawy; David Yaro; Hanadi Zahed
We efficaciously extended the ansatz in the Riccati equation rational expansion technique to a new broad form and is used to attain some new exact wave solutions for the couple non-linear Drinfeld-Sokolov-Wilson (DSW) system. This system arises in water waves, quantum mechanics, fluid mechanics, biology, chemistry etc. Several of the attained solutions which is in the shape of rational solitary wave
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Exopolysaccharide production from isolated Enterobacter sp. strain ACD2 from the northwest of Saudi Arabia J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-28 Mikhlid H. Almutairi; Mohamed M.I. Helal
Substantial interest has emerged on the use of marine microorganisms as producers of important macromolecules such as exopolysaccharides (EPSs), to apply them in areas including the food, pharmaceutical, and cosmetic industries, as well as other important sectors. In this study, thirty seven marine bacterial isolates were isolated from Haqel Beach in Tabuk region, Saudi Arabia. We found that only nine
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Synthesis of 2-mercaptopropionic acid/hydrous zirconium oxide composite and its application for removal of Pb(II) from water samples: Central composite design for optimization J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-17 Nafisur Rahman; Mohd Nasir; Asma A. Alothman; Abdullah M. Al-Enizi; Mohd Ubaidullah; Shoyebmohamad F. Shaikh
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Computational investigations of three main drugs and their comparison with synthesized compounds as potent inhibitors of SARS-CoV-2 main protease (Mpro): DFT, QSAR, molecular docking, and in silico toxicity analysis J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-27 Ranjan K. Mohapatra; Lina Perekhoda; Mohammad Azam; Marharyta Suleiman; Ashish K. Sarangi; Anton Semenets; Lucia Pintilie; Saud I. Al-Resayes
In this study, we examined five previously synthesized compounds and checked their binding affinity towards the SARS-CoV-2 main protease (Mpro) by molecular docking study, and compared the data with three FDA approved drugs, i.e., Remdesivir, Ivermectine and Hydroxychlorochine. In addition, we have investigated the docking study against the main protease of SARS-CoV-2 (Mpro) by using Autodock 4.2 software
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Rheological behavior and storage studies of sprouted onion pastes from four onion varieties J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-05 Ishrat Majid; B.N. Dar; Vikas Nanda; Mona S Alwahibi; Jawaher Alkahtani; Mohamed Soliman Elshikh; Salma Usmani; Mohammad Javed Ansari
Objective The study was carried out to investigate the rheological behavior and storage studies of sprouted onion pastes from four varieties (Punjab White, Punjab Naroya, PRO-6 and commercial). Methods The storage study of paste samples from raw and sprouted onions packaged in polyethylene terephthalate (PET) bottles was carried out at room temperature (25 ± 1 °C) after thermally processing them at
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On the global convergence of a fast Halley’s family to solve nonlinear equations J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-19 Mohammed Barrada; Hamid Bennis; Mostafa Kabbaj; Cherif Ziti
The purpose of this paper is to suggest an approach for increasing the convergence speed of Halley’s method to solve a non-linear equation. This approach is based on the second order Taylor polynomial and on Halley’s formula. By applying it a certain number of times, we obtain a new family of methods. The originality of this family is manifested in the fact that all its sequences are generated from
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Molecular structure simulation of (E)-2-(butan-2-ylidene) hydrazinecarbothioamide using the DFT approach, and antioxidant potential assessment of its complexes J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-24 Tahmeena Khan; Iqbal Azad; Rumana Ahmad; Alfred J. Lawrence; Mohammad Azam; Saikh Mohammad Wabaidur; Saud I. Al-Resayes; Saman Raza; Abdul Rahman Khan
The molecular structure of (E)-2-(butan-2-ylidene)hydrazinecarbothiomide (2-butanone thiosemicarbazone) was validated by density functional theory (DFT) calculations. The characterization of the ligand was done using various spectroscopic techniques. Four transition metal complexes were prepared with the ligand and their antioxidant activity was tested. Molecular docking studies of the complexes were
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Synthesis, physicochemical, thermal, XDR/HSA-interactions of Trans-(1E,2E)-Benzil-O,O-dimethylsulfonyl dioxime: Cis-trans isomerization, DFT and TD-DFT investigation J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-24 Nabil Al-Zaqri; Ali Alsalme; Fahad Alharthi; Afnan Al-Taleb; Ahmed M. Boshaala; Ahmed Chetouni; Abdelkader Zarrouk; Ismail Warad
In this study, a novel trans-(1E,2E)-benzil-O,O-dimethylsulfonyl dioxime (BDMDO) monomer was prepared via a one-step dehydrochlorination reaction. BDMDO was characterized by 1H and 13C NMR, UV–Vis, and FT-IR spectroscopies, CHN elemental analysis, mass spectrometry, energy-dispersive X-ray spectroscopy, and TGA. According to the X-ray diffraction data, the BDMDO crystal structure was solved as a trans-isomer
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Retention profile of As (III) and As (V) oxyanions from water onto polypyrrole J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-23 Salman S. Alharthi
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Morphological and genetic characterization of Fusarium oxysporum and its management using weed extracts in cotton J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2021-01-01 Muhammad Arslan Khan; Sajid Aleem Khan; Ummara Waheed; Muhammad Raheel; Zulqarnain Khan; Abdulwahed F. Alrefaei; Hussein H. Alkhamis
Fusarium oxysporum, a fungal plant pathogen, causes severe wilting and heavy losses in cotton. Present research was planned to appraise the weed extracts of Parthenium hysterophorus, Chenopodium album, Canada thistle and Phalaris minor against F. oxysporum. Morphological identification of F. oxysporum was done by observing white cottony mycelium with dark-purple undersurface on growth media and oval
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Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-30 Apriliana Cahya Khayrani; Rafidha Irdiani; Reza Aditama; Diah Kartika Pratami; Kenny Lischer; Mohammad Javed Ansari; Arunachalam Chinnathambi; Sulaiman Ali Alharbi; Hesham S. Almoallim; Muhamad Sahlan
Coronavirus disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Up to date, there has been no specific cure to treat the disease. Indonesia is one of the countries that is still fighting to control virus transmission. Yet, at the same time, Indonesia has a rich biodiversity of natural medicinal products that potentially become an alternative
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Quantum chemical calculations, spectroscopic properties and molecular docking studies of a novel piperazine derivative J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-18 Olfa Noureddine; Noureddine Issaoui; Sofian Gatfaoui; Omar Al-Dossary; Houda Marouani
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Identification of metabolic pathways involved in the biotransformation of eslicarbazepine acetate using UPLC-MS/MS, human microsomal enzymes and in silico studies J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-18 Asif Husain; Farah Iram; Anees A. Siddiqui; Saeedah Musaed Almutairi; Osama B Mohammed; Shah Alam Khan; Syed Najmul Hejaz Azmi; Nafisur Rahman
In the last few decades, metabolite identification and detection have become an integral component of drug discovery process. The detection and depiction of an identified metabolite is significant for the development of safe and effective therapeutic agents as these metabolites may be pharmacologically active or toxic in nature. A (UPLC-MS/MS) method was developed for the quantification of eslicarbazepine
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The effects of melatonin and vitamin D3 on the gene expression of BCl-2 and BAX in MCF-7 breast cancer cell line J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-18 Abir A. Alamro; Manal M. Al-Malky; Mohammed G.A. Ansari; Osama E. Amer; Abdullah M. Alnaami; Syed D. Hussain; Tlili A. Barhoumi; Amani A. Alghamdi; Samina H. Haq; Shaun Sabico; Nasser M. Al-Daghri
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Application of geochemical modeling using NETPATH and water quality index for assessing the groundwater geochemistry in the south Wadi El-Farigh area, Egypt J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-18 Hend Hussein; Amr Abd El-Raouf; Sattam Almadani; Kamal Abdelrahman; Elkhedr Ibrahim; O.M. Osman
Groundwater quality assessment is of utmost importance for water security in arid areas, such as south of Wadi El-Farigh due to deficiency of recharge, high evaporation rates and groundwater demand for agricultural and drinking utilities. The physicochemical parameters of 25 groundwater samples were investigated. Major ion occurrence was sequenced as Na+ ˃ Ca2+ ˃Mg2+ ˃K+ and Cl− ˃ SO42- ˃HCO3 − ˃ CO3
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A review on microbial degradation of drinks and infectious diseases: A perspective of human well-being and capabilities J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-29 Vijayalakshmi Shankar; Shahid Mahboob; Khalid A. Al-Ghanim; Zubair Ahmed; Norah Al-Mulhm; Marimuthu Govindarajan
Various microorganisms present in beverages as contaminants, yet few can develop in the presence of acidic and low oxygen conditions. Notably, yeast is the dominant microbe group present in the fruit juices and drinks in the fruit juices and drinks. Due to the microbe development and secondary metabolite production, such as polluting compounds, carbon dioxide, and spoilage, the beverages were identified
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Physio-chemical properties of groundwater and their environmental hazardous impact: Case study of Southwestern Saudi Arabia J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-19 Ali Y. Kahal; Hussain J. Alfaifi; Kamal Abdelrahman; Faisal K. Zaidi
Southwestern Saudi Arabia is enriched with fractured and highly-weathered igneous and metamorphic rocks that function as the limited aquifer and supply significant quantities of water for household use and agriculture in this area. Twenty-seven groundwater samples were collected from shallow-dug wells and physio-chemically examined. It is displayed that, however the average value of total dissolved
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New flavane gallates from the aerial part of an African/Arabian medicinal plant Plicosepalus curviflorus by LC–MS and NMR based molecular characterization J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-18 Areej Mohammad Al-Taweel; Shagufta Perveen; Saleh Ibrahim Alqasoumi; Raha Orfali; Hanan Y. Aati; Shahnaz; Ebtesam Nasser Alsultan; Bandar Alghanem; Hayat Shaibah
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A review on biological carbon sequestration: A sustainable solution for a cleaner air environment, less pollution and lower health risks J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-17 R. Gayathri; Shahid Mahboob; Marimuthu Govindarajan; Khalid A. Al-Ghanim; Zubair Ahmed; Norah Al-Mulhm; Masa Vodovnik; Shankar Vijayalakshmi
Carbon dioxide gas is the key element of the carbon cycle and a major source for photosynthesis, but for the past 150 years, the atmospheric CO2 has been increased drastically from 250 to 418 ppm due to the extreme utilization of fossil fuels. This accelerated release of CO2 acts as a major source for climatic change due to the greenhouse gas effect resulting in global warming and melting of polar
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Risk assessment of malathion on health indicators of catfish: Food and water security prospective research J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-25 Z. Ahmad; H.F. Alkahem Al-Balawi; K.A. Al-Ghanim; F. Al-Misned; S. Mahboob
Specimens of Heteropneustes fossilis were treated with various levels of malathion and its 96 h LC50 value was determined. The effects of sub-lethal concentrations of insecticide on hematological and biochemical profile of Heteropneustes fossilis were also registered. The 96 h LC50 value obtained was 8.81 mg/l. Exposure of sub-lethal doses (0.44, 0.88 and 1.76 mg/l which are 5, 10 and 20% of the LC50)
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First molecular data and morphological re-description of two copepod species, Hatschekia sargi and Hatschekia leptoscari, as parasites on Parupeneus rubescens in the Arabian Gulf J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-24 Saleh Al-Quraishy; Mohamed A. Dkhil; Nawal Al-Hoshani; Wejdan Alhafidh; Rewaida Abdel-Gaber
Little information is available about the biodiversity of parasitic copepods in the Arabian Gulf. The present study aimed to provide new information about different parasitic copepods gathered from Parupeneus rubescens caught in the Arabian Gulf (Saudi Arabia). Copepods collected from the infected fish were studied using light microscopy and scanning electron microscopy and then examined using standard
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MiR-15a regulates bicuspid aortic valve calcification via TGF-β signaling pathway via inhibiting Smad7 J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-15 Jiankang Xu; Hao Liu; Rui Zheng; Minyan Dang; Yongfeng Shao; Junjie Du
Background Bicuspid aortic valve is a heritable heart valve disease with characteristic early onset of valve calcification and stenosis with rapid progression compared with tricuspid aortic valve. Strong evidence indicates that many miRNAs and their target genes are involved in the development of BAV calcification. This study was designed to investigate miR-15a and Smad7 expressions in BAV and their
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Identification of potential riboflavin synthase inhibitors by virtual screening and molecular dynamics simulation studies J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-04 Sayangku Nor Ariati Mohamad Aris; Mohd Zulhilmi Abdul Rahman; Raja Noor Zaliha Raja Abd Rahman; Mohd Shukuri Mohamad Ali; Abu Bakar Salleh; Chian Ying Teo; Thean Chor Leow
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Landslide hazard assessment of the Neom promising city, northwestern Saudi Arabia: An integrated approach J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-16 Ali Y. Kahal; Kamal Abdelrahman; Hussain J. Alfaifi; Madyan M.A. Yahya
Landslides hazard as one of the major environmental threats of the Neom promising city in northwestern Saudi Arabia has been assessed through data integration of several sources including topographic, geologic, and seismologic data sets. Moreover, Landsat imagery and historical landslide data are introduced in assessing landslide susceptibility of the study area. All these data oriented to generate
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Groundwater contamination with the threat of COVID-19: Insights into CSR theory of Carroll's pyramid J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-17 Chunhui Huo; Afzal Ahmed Dar; Ahsan Nawaz; Javaria Hameed; Gadah albashar; Bao Pan; Chuanyi Wang
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Probiotic lactobacilli: Can be a remediating supplement for pandemic COVID-19. A review J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-16 Mysoon M. Al-Ansari; Samer A. Sahlah; Lateefah AlHumaid; A.J. Ranjit Singh
In recent years increased attention is focussed on microorganisms inhabiting the digestive system that provides prophylactic and therapeutic benefits to the host. After Metchnikoff exposed the secret behind Bulgarian peasants' extended longevity, a graze to incorporate the responsible microbes in functional food emerged. Then interest towards microbe-rich food went to the vegetative phase for some
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Approximate analytical solutions for some obstacle problems J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-08 Mourad Chamekh; Mohamed Ali Latrach; Tarig M. Elzaki
The paper deals with the variational iteration method to obtain a semi-analytical solution to some obstacle problems. We will focus on applications of a contact problem for a deformed beam with an elastic obstacle. To validate the accuracy this approach,the obtained solution has been compared with the exact solution, in the case where it can be calculated in the closed-form expression. Otherwise, a
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Functionalized multi walled carbon nanotubes supported copper-titania nanoparticles for oxidation of cinnamyl alcohol under mild reaction conditions J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-08 Zahoor Iqbal; Muhammad Sadiq; Muhammad Sufaid Khan; Tausif Iqbal; Mumtaz Ali; Muhammad Zahoor; Riaz Ullah; Hesham S. Almoallim; Sulaiman Ali Alharbi
Objectives Alcohols oxidation is one of the important organic transformation in fine chemical industries. Prevailing processes are hazardous due to involvement of stoichiometric oxidants and homogeneous catalysts. In the present work, oxidation of cinnamyl alcohol was carried out using unconventional, affordable, and feasible heterogeneous catalysts. Method Copper-titania (Cu-Ti) nanoparticles were
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Biosynthesis of gold nanoparticles using marine microbe (Vibrio alginolyticus) and its anticancer and antioxidant analysis J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-04 Rajeshkumar Shunmugam; Sri Renukadevi Balusamy; Venkat Kumar; Soumya Menon; T. Lakshmi; Haribalan Perumalsamy
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Evaluation of hydrocarbon source rock potential: Deep marine shales of Belaga Formation of Late Cretaceous-Late Eocene, Sarawak, Malaysia J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-05 Nisar Ahmed; Numair A. Siddiqui; Abdul H. B. A. Rahman; Muhammad Jamil; Muhammad Usman; Zulqarnain Sajid; Faisal Kamal Zaidi
In the Sibu-Tatau region of Sarawak, the Belaga Formation (Late Cretaceous- Late Eocene turbidites) is interpreted in relation to a submarine fan model deposited in the extinct ocean basin of the proto-South China Sea. A number of clastic rocks, which include sandstone, siltstone, mudstone, and black shale, define the formation. While it is considered one of the Rajang group's extensive and well-studied
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Environmental hazard assessment for ground failure in Jeddah city, western Saudi Arabia, through cross-hole seismic testing J. King Saud Univ. Sci. (IF 3.819) Pub Date : 2020-12-08 Kamal Abdelrahman; Naif Al-Otaibi; Elkhedr Ibrahim
The environmental threats of soil subsistence in Jeddah city have been assessed using cross-hole seismic testing. These threats affect the state of health of roads, buildings, near-surface foundations ensuring a reliable and economic infrastructure design, as unanticipated site conditions can cause significant traffic problems, soil subsidence, and structural collapse. Cross-hole seismic testing is
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