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A novel therapy for fracture healing by increasing lymphatic drainage J. Orthop. Translat. (IF 6.6) Pub Date : 2024-03-13 Yangkang Zheng, Pengyu Wang, Li Zhao, Lianping Xing, Hao Xu, Ning Li, Yongjian Zhao, Qi Shi, Qianqian Liang, YongJun Wang
The musculoskeletal system contains an extensive network of lymphatic vessels. Decreased lymph flow of the draining collecting lymphatics usually occurs in clinic after traumatic fractures. However, whether defects in lymphatic drainage can affect fracture healing is unclear. To investigate the effect of lymphatic dysfunction on fracture healing, we used a selective VEGFR3 tyrosine kinase inhibitor
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Pentamidine-loaded gelatin decreases adhesion formation of flexor tendon J. Orthop. Translat. (IF 6.6) Pub Date : 2024-03-13 Guidong Shi, Nakagawa Koichi, Rou Wan, Yicun Wang, Ramona Reisdorf, Abigayle Wilson, Tony C.T. Huang, Peter C. Amadio, Alexander Meves, Chunfeng Zhao, Steven L. Moran
Prevention of adhesion formation following flexor tendon repair is essential for restoration of normal finger function. Although many medications have been studied in the experimental setting to prevent adhesions, clinical application is limited due to the complexity of application and delivery in clinical translation. In this study, optimal dosages of gelatin and pentamidine were validated by gelatin
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Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment J. Orthop. Translat. (IF 6.6) Pub Date : 2024-03-12 Yang Liu, Yiming Dou, Xun Sun, Qiang Yang
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory phenotype can create an inflammatory and catabolic environment through autocrine and paracrine ways, ultimately affecting tissue microstructure. As
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Clinical guideline on the third generation minimally invasive surgery for hallux valgus J. Orthop. Translat. (IF 6.6) Pub Date : 2024-03-11 Guangyi Li, Hui Zhang, Xu Wang, Yunfeng Yang, Hailin Xu, Jinsong Hong, Siu-Wah Kong, Kwok-Bill Chan, Keen-Wai Chong, Alan Yan, Zhongmin Shi, Xin Ma, Foot and Ankle Committee of Orthopedic Branch of the Chinese Medical Doctor Association Foot and Ankle Committee of Sports Medicine Branch of Chinese Medical Doctor Association Foot and Ankle Expert Committee of the Chinese Association for Integrative
Minimally invasive surgery for hallux valgus correction, has been attracting great interests in the recent decades, due to the potential benefits of less pain, decreased recovery times, smaller scars with better cosmesis, and improved early post-operative range of motion. The most recent developments in minimally invasive surgery have evolved into the third generation with modifications of the chevron-type
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Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies J. Orthop. Translat. (IF 6.6) Pub Date : 2024-03-08 Baoqi Li, Pascal Thebault, Béatrice Labat, Guy Ladam, Volker Alt, Markus Rupp, Christoph Brochausen, Jonathan Jantsch, Margaret Ip, Ning Zhang, Wing-Hoi Cheung, Shui Yee Sharon Leung, Ronald Man Yeung Wong
Fracture-related infection (FRI) remains a major concern in orthopaedic trauma. Functionalizing implants with antibacterial coatings are a promising strategy in mitigating FRI. Numerous implant coatings have been reported but the preventive and therapeutic effects vary. This systematic review aimed to provide a comprehensive overview of current implant coating strategies to prevent and treat FRI in
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Pip5k1c expression in osteocytes regulates bone remodeling in mice J. Orthop. Translat. (IF 6.6) Pub Date : 2024-03-08 Sixiong Lin, Chu Tao, Qinnan Yan, Huanqing Gao, Lei Qin, Yiming Zhong, Qing Yao, Peijun Zhang, Jiaming Yang, Xuenong Zou, Guozhi Xiao
The role of osteocytes in maintaining bone mass has been progressively emphasized. Pip5k1c is the most critical isoform among PIP5KIs, which can regulate cytoskeleton, biomembrane, and Ca release of cells and participate in many processes, such as cell adhesion, differentiation, and apoptosis. However, its expression and function in osteocytes are still unclear. To determine the function of Pip5k1c
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Shock wave assisted intracellular delivery of antibiotics against bone infection with Staphylococcus aureus via P2X7 receptors J. Orthop. Translat. (IF 6.6) Pub Date : 2024-02-27 Jiangbi Li, Haixia Li, Songqi Bi, Yang Sun, Feng Gu, Tiecheng Yu
Treatment of chronic osteomyelitis (bone infection) remains a clinical challenge; in particular, it requires enhanced delivery of antibiotic drugs for the treatment of intracellular (), which prevents infection recurrence and resistance. Previous studies have found that noninvasive shock waves used to treat musculoskeletal diseases can alter cell permeability, however, it is unclear whether shock waves
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Intra-articular injection of platelet lysate-derived extracellular vesicles recovers from knee osteoarthritis in an in vivo rat model J. Orthop. Translat. (IF 6.6) Pub Date : 2024-02-08 Maria Antònia Forteza-Genestra, Miquel Antich-Rosselló, Carmen Ráez-Meseguer, Anna Tomàs Sangenís, Javier Calvo, Antoni Gayà, Marta Monjo, Joana Maria Ramis
MSCs and Platelet-Rich Plasma are the main focus in the study of new regenerative treatments aimed to reverse Osteoarthritis (OA). However, extracellular vesicles (EVs) present several advantages to cell-based treatments. Thus, the aim of this study was to compare and evaluate the regenerative potential of MSC-derived EVs (cEVs) and platelet-derived EVs (pEVs) in an OA cartilage rat model. OA in vivo
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Advances in osteoarthritis research: From diagnosis, treatment to mechanism studies J. Orthop. Translat. (IF 6.6) Pub Date : 2024-02-06 Zhongyang Lv, Ziling Wang, Di Chen, Dongquan Shi
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ChatGPT for scientific writing — The coexistence of opportunities and challenges J. Orthop. Translat. (IF 6.6) Pub Date : 2024-02-06 Liangbin Zhou, Alex Chao Wu, Péter Hegyi, Chunyi Wen, Ling Qin
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Inhibition of PI3K/AKT signaling pathway prevents blood-induced heterotopic ossification of the injured tendon J. Orthop. Translat. (IF 6.6) Pub Date : 2024-02-02 Yuwei Yang, Yuqing Gu, Junzhi Yi, Wenyu Yao, Zhuomin Sha, Hongwei Wu, Yunting Zhou, Zhonglin Wu, Fangyuan Bao, Jiasheng Wang, Ying Wang, Yuanhao Xie, Chenlu Gao, Boon Chin Heng, Hua Liu, Zi Yin, Xiao Chen, Jing Zhou, Hongwei Ouyang
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G protein-coupled receptor 30 activation inhibits ferroptosis and protects chondrocytes against osteoarthritis J. Orthop. Translat. (IF 6.6) Pub Date : 2024-01-28 Zhen Zhao, Shun Niu, Jun Chen, Hongtao Zhang, Lizuo Liang, Kui Xu, Chuan Dong, Chang Su, Tao Yan, Yongqiang Zhang, Hua Long, Le Yang, Minggao Zhao
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XJB-5-131 protects chondrocytes from ferroptosis to alleviate osteoarthritis progression via restoring Pebp1 expression J. Orthop. Translat. (IF 6.6) Pub Date : 2024-01-22 Wei Sun, Zhongyang Lv, Weitong Li, Jun Lu, Ya Xie, Peng Wang, Ruiyang Jiang, Jian Dong, Hu Guo, Zizheng Liu, Yuxiang Fei, Guihua Tan, Maochun Wang, Kewei Ren, Jun Xu, Huiqing Sun, Xuefeng Jiang, Dongquan Shi
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Computational screening of biomarkers and potential drugs for arthrofibrosis based on combination of sequencing and large nature language model J. Orthop. Translat. (IF 6.6) Pub Date : 2024-01-20 Xi Chen, Cheng Li, Ziyuan Wang, Yixin Zhou, Ming Chu
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Targeting FGFR3 signaling and drug repurposing for the treatment of SLC26A2-related chondrodysplasia in mouse model J. Orthop. Translat. (IF 6.6) Pub Date : 2024-01-06 Pan Li, Dong Wang, Weiguang Lu, Xin He, Jingyan Hu, Haitao Yun, Chengxiang Zhao, Liu Yang, Qiang Jie, Zhuojing Luo
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JD-312 – A novel small molecule that facilitates cartilage repair and alleviates osteoarthritis progression J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-30 Jingduo Gao, Haixiang Pei, Fang Lv, Xin Niu, Yu You, Liang He, Shijia Hu, Karan M. Shah, Mingyao Liu, Yihua Chen, Bing Du, Hai Xiong, Jian Luo
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Combination of a human articular cartilage-derived extracellular matrix scaffold and microfracture techniques for cartilage regeneration: A proof of concept in a sheep model J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-30 Liqing Peng, Hao Li, Haoyuan Deng, Tianze Gao, Runmeng Li, Ziheng Xu, Qinyu Tian, Tianyuan Zhao, Jianwei Li, Yongkang Yang, Chao Wang, Shuyun Liu, Quanyi Guo
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Elevated secretion of pro-collagen I-alpha and vascular endothelial growth factor as biomarkers of acetabular labrum degeneration and calcification in hip osteoarthritis: An explant study J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-26 Alexander Antoniadis, Julien Wegrzyn, Patrick Omoumi, Léa Loisay, Thomas Hügle, Jeroen Geurts
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The silencing of NREP aggravates OA cartilage damage through the TGF-β1/Smad2/3 pathway in chondrocytes J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-27 Yang Liu, Mengrou Liu, Chengming Zhang, Xiaoke Li, Siyu Zheng, Le Wen, Peidong Liu, Pengcui Li, Ziquan Yang
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TCF12 regulates the TGF-β/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4 J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-27 Hui Zheng, Jianli Fang, Wei Lu, Youhui Liu, Sixu Chen, Guangxin Huang, Yuming Zou, Shu Hu, Yongxu Zheng, Hang Fang, Rongkai Zhang
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The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-29 Hao Tang, Xiaoshan Gong, Jingjin Dai, Jun Gu, Zicai Dong, Yuan Xu, Zhaoyang Hu, Chunrong Zhao, Jiezhong Deng, Shiwu Dong
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Repairing, reconstructing, and recovering after COVID-19 J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-23 Tingting Tang
Abstract not available
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Daily low-intensity pulsed ultrasound stimulation mitigates joint degradation and pain in a post-traumatic osteoarthritis rat model J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-20 Wonsae Lee, Elias Georgas, David E. Komatsu, Yi-Xian Qin
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The association between anterior cruciate ligament degeneration and incident knee osteoarthritis: Data from the osteoarthritis initiative J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-14 Ping Luo, Qianyi Wang, Peihua Cao, Tianyu Chen, Shengfa Li, Xiaoshuai Wang, Yamin Li, Ze Gong, Yan Zhang, Guangfeng Ruan, Zuoqing Zhou, Yuanyuan Wang, Weiyu Han, Zhaohua Zhu, David J. Hunter, Jia Li, Changhai Ding
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Melatonin alleviates oxidative stress-induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway J. Orthop. Translat. (IF 6.6) Pub Date : 2023-12-02 Ze-Nan Huang, Ze-Yu Wang, Xiao-Fei Cheng, Zhao-Zhang Huang, Yan-Ling Han, Ya-Zhou Cui, Bo Liu, Wei Tian
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Choosing the right animal model for osteomyelitis research: Considerations and challenges J. Orthop. Translat. (IF 6.6) Pub Date : 2023-11-29 Shen Huang, Jing Wen, Yiqing Zhang, Xiaochun Bai, Zhong-Kai Cui
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Recent advances in understanding molecular mechanisms and novel strategies for the treatment of osteoarthritis and other diseases related with cartilage defects J. Orthop. Translat. (IF 6.6) Pub Date : 2023-11-18 Jiawei Li, Dongquan Shi, Di Chen
Abstract not available
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“Innovation and translation of biological and biomaterial treatment for challenging musculoskeletal disorders” J. Orthop. Translat. (IF 6.6) Pub Date : 2023-11-11 Ling Qin
Abstract not available
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Muscle-bone crosstalk via endocrine signals and potential targets for osteosarcopenia-related fracture J. Orthop. Translat. (IF 6.6) Pub Date : 2023-11-05 Renwang Sheng, Mumin Cao, Mingyuan Song, Mingyue Wang, Yuanwei Zhang, Liu Shi, Tian Xie, Yingjuan Li, Jinyu Wang, Yunfeng Rui
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Silicone rubber sealed channel induced self-healing of large bone defects: Where is the limit of self-healing of bone? J. Orthop. Translat. (IF 6.6) Pub Date : 2023-11-01 Feng Gu, Ke Zhang, Wan-an Zhu, Zhenjiang Sui, Jiangbi Li, Xiaoping Xie, Tiecheng Yu
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COVID-19 hip fracture outcomes: The role of Ct values and D-dimer levels? J. Orthop. Translat. (IF 6.6) Pub Date : 2023-10-23 Kwan Hung Moya Tsui, Wai Wang Chau, Wing Hong Liu, Cheuk Yin Tam, Dennis King Hang Yee, Chi Yin Tso, Ning Zhang, Wing-Hoi Cheung, Ning Tang, Ronald Man Yeung Wong
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A systematic investigation of the effects of TGF-β3 and mechanical stimulation on tenogenic differentiation of mesenchymal stromal cells in a poly(ethylene glycol)/gelatin-based hydrogel J. Orthop. Translat. (IF 6.6) Pub Date : 2023-10-21 Ilze Donderwinkel, Rocky S. Tuan, Neil R. Cameron, Jessica E. Frith
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Chronic pain after spine surgery: Insights into pathogenesis, new treatment, and preventive therapy J. Orthop. Translat. (IF 6.6) Pub Date : 2023-09-30 Qichao Wu, Xiang Cui, Leo C. Guan, Chi Zhang, Jing Liu, Neil C. Ford, Shaoqiu He, Xueming Chen, Xu Cao, Lei Zang, Yun Guan
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Efficacy and safety of unilateral tibial cortex transverse transport on bilateral diabetic foot ulcers: A propensity score matching study J. Orthop. Translat. (IF 6.6) Pub Date : 2023-09-14 Wencong Qing, Xinyu Nie, Hongjie Su, Yi Ding, Lihuan He, Kaibing Liu, Jun Hou, Kaixiang Pan, Liexun He, Sijie Yang, Lisha Li, Shenghui Yang, Xiao Peng, Jinming Zhao, Jack Guan, Xiaocong Kuang, Qikai Hua
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Biomaterial-based scaffolds in promotion of cartilage regeneration: Recent advances and emerging applications. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-09-04 Jingqi Liang,Peilong Liu,Xinquan Yang,Liang Liu,Yan Zhang,Qiong Wang,Hongmou Zhao
Osteoarthritis (OA) poses a significant burden for countless individuals, inflicting relentless pain and impairing their quality of life. Although traditional treatments for OA focus on pain management and surgical interventions, they often fall short of addressing the underlying cause of the disease. Fortunately, emerging biomaterial-based scaffolds offer hope for OA therapy, providing immense promise
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Modulating design parameters to drive cell invasion into hydrogels for osteochondral tissue formation. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-09-04 Andrea Schwab,Marinus A Wesdorp,Jietao Xu,Florencia Abinzano,Claudia Loebel,Marc Falandt,Riccardo Levato,David Eglin,Roberto Narcisi,Martin J Stoddart,Jos Malda,Jason A Burdick,Matteo D'Este,Gerjo J V M van Osch
Background The use of acellular hydrogels to repair osteochondral defects requires cells to first invade the biomaterial and then to deposit extracellular matrix for tissue regeneration. Due to the diverse physicochemical properties of engineered hydrogels, the specific properties that allow or even improve the behaviour of cells are not yet clear. The aim of this study was to investigate the influence
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3D printing metal implants in orthopedic surgery: Methods, applications and future prospects J. Orthop. Translat. (IF 6.6) Pub Date : 2023-09-01 Meng Meng, Jinzuo Wang, Huagui Huang, Xin Liu, Jing Zhang, Zhonghai Li
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DFATs derived from infrapatellar fat pad hold advantage on chondrogenesis and adipogenesis to evade age mediated influence J. Orthop. Translat. (IF 6.6) Pub Date : 2023-09-01 Yuan-Chao Sun, Pei-Hung Shen, Chih-Chien Wang, Hsin-Ya Liu, Chieh-Hua Lu, Sheng-Chiang Su, Jhih-Syuan Liu, Peng-Fei Li, Chia-Luen Huang, Li-Ju Ho, Yi-Jen Hung, Chien-Hsing Lee, Feng-Chih Kuo
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The novel magnesium–titanium hybrid cannulated screws for the treatment of vertical femoral neck fractures: Biomechanical evaluation J. Orthop. Translat. (IF 6.6) Pub Date : 2023-09-02 Qida Zhang, Zhenxian Chen, Yinghu Peng, Zhongmin Jin, Ling Qin
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Discovery of multipotent progenitor cells from human induced membrane: Equivalent to periosteum-derived stem cells in bone regeneration J. Orthop. Translat. (IF 6.6) Pub Date : 2023-08-30 Hongri Wu, Jiulin Tan, Dong Sun, Xiaohua Wang, Jie Shen, Shulin Wang, Qijie Dai, Zhiyuan Wei, Gang Li, Sien Lin, Fei Luo, Zhao Xie
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Stem cell-based therapeutic strategies for rotator cuff tendinopathy J. Orthop. Translat. (IF 6.6) Pub Date : 2023-08-23 Zetao Wang, Youguo Liao, Canlong Wang, Chenqi Tang, Cailian Fang, Junchao Luo, Hengzhi Liu, Xianan Mo, Zicheng Wang, Lingfang Shen, Junjuan Wang, Xiao Chen, Zi Yin, Jianyou Li, Weiliang Shen
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Magnetic resonance imaging techniques for the quantitative analysis of skeletal muscle: State of the art J. Orthop. Translat. (IF 6.6) Pub Date : 2023-08-19 Klaus Engelke, Oliver Chaudry, Lena Gast, Mootaz AB. Eldib, Ling Wang, Jean-Denis Laredo, Georg Schett, Armin M. Nagel
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Animal model for tendinopathy J. Orthop. Translat. (IF 6.6) Pub Date : 2023-08-14 Junchao Luo, Zetao Wang, Chenqi Tang, Zi Yin, Jiayun Huang, Dengfeng Ruan, Yang Fei, Canlong Wang, Xianan Mo, Jiajin Li, Jun Zhang, Cailian Fang, Jianyou Li, Xiao Chen, Weiliang Shen
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Disruption of Col9a2 expression leads to defects in osteochondral homeostasis and osteoarthritis-like phenotype in mice. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-08-14 Rui Dong,Huihui Xu,Pinger Wang,Liang Fang,Luwei Xiao,Shuaijie Lv,Peijian Tong,Hongting Jin
Background/Objective As one of the branched chains of Type IX collagen (Col9), Collagen IX alpha2 (Col9a2) has been reported to be associated with several orthopedic conditions. However, the relationship between Col9a2 and knee osteoarthritis (KOA) remains to be elucidated. Methods To probe the relationship between Col9a2 and KOA, we performed a systematic analysis of Col9a2-deficient (Col9a2-/-) mice
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MATN3 delivered by exosome from synovial mesenchymal stem cells relieves knee osteoarthritis: Evidence from in vitro and in vivo studies. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-08-11 Long Long,Guoyou Zou,Yi Cheng,Feng Li,Hao Wu,Yixin Shen
Background Synovial mesenchymal stem cell (SMSC) exerts chondroprotective effects in osteoarthritis (OA) clinical models. However, the regulatory potentials of SMSC-derived exosomes (SMSC-Exo) in OA still need to be discovered, which attracted our attention. Methods The destabilization of the medial meniscus surgery was performed on the knee joints of a mouse OA model, followed by injection of SMSC-Exo
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Sustained notch signaling inhibition with a gamma-secretase inhibitor prevents traumatic heterotopic ossification J. Orthop. Translat. (IF 6.6) Pub Date : 2023-08-01 Zheng Wang, Xinzeyu Yi, Chao Jian, Baiwen Qi, Qiaoyun Liu, Zonghuan Li, Aixi Yu
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Kartogenin-enhanced dynamic hydrogel ameliorates intervertebral disc degeneration via restoration of local redox homeostasis J. Orthop. Translat. (IF 6.6) Pub Date : 2023-07-31 Xin Tian, Yijian Zhang, Lei Shen, Guoqing Pan, Huilin Yang, Zhenhuan Jiang, Xuesong Zhu, Fan He
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Eurycomanone stimulates bone mineralization in zebrafish larvae and promotes osteogenic differentiation of mesenchymal stem cells by upregulating AKT/GSK-3β/β-catenin signaling. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-15 Yan-Ting Zhong,Hong-Bo Liao,Zhi-Qiang Ye,Hua-Sheng Jiang,Jia-Xiao Li,Lin-Mao Ke,Jun-Ying Hua,Bo Wei,Xin Wu,Liao Cui
Background Eurycomanone (EN) is a diterpenoid compound isolated from the roots of Eurycoma longifolia (E. longifolia). Previous studies have confirmed that E. longifolia can enhance bone regeneration and bone strength. We previously isolated and identified ten quassinoids from E. longifolia, and the result displayed that five aqueous extracts have the effects on promotion of bone formation, among whom
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Gli1 depletion induces oxidative stress and apoptosis of nucleus pulposus cells via Fos in intervertebral disc degeneration. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-13 Libangxi Liu,Yuyao Zhang,Jiawei Fu,Xuezheng Ai,Dan Long,Xue Leng,Yang Zhang,Bo Huang,Changqing Li,Yue Zhou,Chencheng Feng
Background Intervertebral disc degeneration (IDD) is the most common chronic disease. Oxidative stress and apoptosis of nucleus pulposus (NP) cells disrupt intervertebral disc (IVD) homeostasis, which is the main cause of IDD. Glioma-associated oncogene 1 (Gli1) is an important transcription factor in the Hedgehog (Hh) pathway. Depletion of Gli1 accelerates the occurrence and development of degenerative
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Metformin improves fibroblast metabolism and ameliorates arthrofibrosis in rats. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-12 Zhenglin Zhu,Shengqiang Gao,Hui Zhu,Yi Chen,Dandong Wu,Zhiyu Chen,Yanran Huang,Xiangdong Wu,Ning Hu,Di Chen,Wei Huang,Hong Chen
Background Emerging studies have suggested an essential role of fibroblast metabolic reprogramming in the pathogenesis of arthrofibrosis. The metabolic modulator metformin appears to be a therapeutic candidate for fibrotic disorders. However, whether metformin could alleviate arthrofibrosis has not been defined. In this study we have determined if treatment with metformin has beneficial effect on arthrofibrosis
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Stress stimulation maintaining by genipin crosslinked hydrogel promotes annulus fibrosus healing. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-12 Zihan Wang,Xiaoyu Jin,Botao Zhang,Jiaxin Kong,Rongrong Deng,Ke Wu,Lin Xie,Xin Liu,Ran Kang
Objective To explore the repair effect of tissue engineering for annulus fibrosus (AF) injury in stress-stimulation environment. Methods Non-adhesive fibrinogen (Fib) representing the repair with non-stress stimulation and adhesive hydrogel of fibrinogen, thrombin and genipin mixture (Fib-T-G) representing the repair with stress stimulation were prepared to repair the AF lesion. The relationship between
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USP7 promotes the osteoclast differentiation of CD14+ human peripheral blood monocytes in osteoporosis via HMGB1 deubiquitination. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-11 Yu-Cong Lin,Guan Zheng,Hua-Tao Liu,Peng Wang,Wei-Quan Yuan,Yun-Hui Zhang,Xiao-Shuai Peng,Guo-Jian Li,Yan-Feng Wu,Hui-Yong Shen
Background Abnormal osteoclast and osteoblast differentiation is an essential pathological process in osteoporosis. As an important deubiquitinase enzyme, ubiquitin-specific peptidase 7 (USP7) participates in various disease processes through posttranslational modification. However, the mechanism by which USP7 regulates osteoporosis remains unknown. Herein, we aimed to investigate whether USP7 regulates
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Platelet-derived extracellular vesicles formulated with hyaluronic acid gels for application at the bone-implant interface: An animal study. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-10 Miquel Antich-Rosselló,Maria Antònia Forteza-Genestra,Hans Jacob Ronold,Staale Petter Lyngstadaas,Mario García-González,María Permuy,Mónica López-Peña,Fernando Muñoz,Marta Monjo,Joana M Ramis
Background/Objective Platelet derived extracellular vesicles (pEV) are promising therapeutical tools for bone healing applications. In fact, several in vitro studies have already demonstrated the efficacy of Extracellular Vesicles (EV) in promoting bone regeneration and repair in various orthopedic models. Therefore, to evaluate the translational potential in this field, an in vivo study was performed
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Osteocyte β3 integrin promotes bone mass accrual and force-induced bone formation in mice. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-07 Lei Qin,Zecai Chen,Dazhi Yang,Tailin He,Zhen Xu,Peijun Zhang,Di Chen,Weihong Yi,Guozhi Xiao
Background Cell culture studies demonstrate the importance of β3 integrin in osteocyte mechanotransduction. However, the in vivo roles of osteocyte β3 integrin in the regulation of bone homeostasis and mechanotransduction are poorly defined. Materials and methods To study the in vivo role of osteocyte β3 integrin in bone, we utilized the 10-kb Dmp1 (dentin matrix acidic phosphoprotein 1)-Cre to delete
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HIF-1α dependent RhoA as a novel therapeutic target to regulate rheumatoid arthritis fibroblast-like synoviocytes migration in vitro and in vivo. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-06 Jianhai Chen,Jingqin Chen,Jianwei Tan,Jian Li,Wenxiang Cheng,Liqing Ke,Qijing Wang,Anqiao Wang,Sien Lin,Gang Li,Peng Zhang,Benguo Wang
Objective The purpose of this work is to investigate how the Rho family of GTPases A (RhoA) mediates the pathogenesis of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS). Methods The expression of RhoA in the synovial tissues of RA and Healthy people (Control) was detected using immunohistochemistry methods. The expression of RhoA and hypoxia-inducible factor-1α (HIF-1α) is inhibited by small
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Metformin attenuates diabetes-induced osteopenia in rats is associated with down-regulation of the RAGE-JAK2-STAT1 signal axis. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-06-03 Rui Lin,Bilian Xu,Zhiqiang Ye,Yin Gao,Haiping Fang,Jintong Song,Dahong Liang,Lingna Liu,Zilong Hu,Min Zhang,Jinsong Wei,Feifu Deng,Xiangxin Zhong,Liao Cui,Yanzhi Liu
Background Osteopenia and fragile fractures are diabetes-associated complications. Many hypoglycemic drugs have effects on bone metabolism. Metformin, as is a prescribed medication for type 2 diabetes mellitus (T2DM), had been reported to have osteoprotective effects beyond its hypoglycemic effect, however the potential mechanism behind these effects remains unclear. In this study, we aimed to investigate
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Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in mice J. Orthop. Translat. (IF 6.6) Pub Date : 2023-05-31 Qing Yao, Weiyuan Gong, Xiaohao Wu, Donghao Gan, Chu Tao, Sixiong Lin, Minghao Qu, Zhongtian Ouyang, Mingjue Chen, Xinjia Hu, Guozhi Xiao
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Polymer bilayer-Micro arc oxidation surface coating on pure magnesium for bone implantation. J. Orthop. Translat. (IF 6.6) Pub Date : 2023-05-24 Jieyang Dong,Jiaqi Zhong,Ruixia Hou,Xiaodong Hu,Yujiong Chen,Hangbin Weng,Zhewei Zhang,Botao Liu,Shengbing Yang,Zhaoxiang Peng
Background Pure magnesium-based ortho-implants have a number of advantages. However, vital parameters like degradation rate and biocompatibility still call for significant improvement. Methods In this study, poly (1,3-trimethylene carbonate) (PTMC) and polydopamine (PDA) bilayer and micro arc oxidation composite coatings were prepared successively on magnesium surface by immersion method and microarc