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Correction to “Chronic Systemic Infection of Mice with Leishmania infantum Leads to Increased Bone Mass” J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-11-30
Lai C, Heinemann J, Schleicher U, et al. Chronic systemic infection of mice with Leishmania infantum leads to increased bone mass. J Bone Miner Res. 2023;38(1):86–102. https://doi.org/10.1002/jbmr.4733 In the Author Contributions, the text “C.L. designed and performed the experiments and analyzed the data” is incomplete. The correct text is: “C.L. designed and performed the experiments and analyzed
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2023 Annual Meeting of the American Society for Bone and Mineral Research, Vancouver, BC, October 13–16, 2023 J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-11-17
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Therapeutic Potential of Cannabidiol and Cannabigerol in Fracture Healing. J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-11-17 Yankel Gabet
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The Impact of Whole Egg Consumption on Bone Accrual in Healthy Children: A Randomized Controlled Trial J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-11-11 Lauren M. Coheley, Mengyun Yu, Xianyan Chen, Patrick J. O'Connor, Kirk S. Kealey, Emma M. Laing, Assaf Oshri, Alicia K. Marand, Julia M. Lance, Joseph M. Kindler, Richard D. Lewis
Dietary interventions designed to examine the role of nutrition on childhood bone accrual have often focused on the role of individual micronutrients (eg, calcium, vitamin D, and zinc) and macronutrients (eg, protein). The osteogenic benefits of whole foods, such as eggs, are not well understood despite eggs being a source of high-quality nutrients and bioactive compounds known to positively influence
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Causal Relationship Between Sarcopenia and Fracture: A Two-Sample Mendelian Randomized Study. J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-11-07 Qifeng Ou,Ding Pan
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Denosumab and Mortality in a Real-World Setting: A Comparative Study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-11-01 Dunia Alarkawi, Thach Tran, Weiwen Chen, Lyn M March, Fiona M Blyth, Robert D Blank, Dana Bliuc, Jacqueline R Center
Denosumab (Dmab) is increasingly prescribed worldwide. Unlike bisphosphonates (BPs), its effect on mortality has yet to be well explored. This study examined the association between Dmab and all-cause mortality compared with no treatment in subjects with a fracture and BPs in subjects without a fracture. The study population was from the Sax Institute's 45 and Up Study (n = 267,357), a prospective
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Bone Marrow Adiposity Alterations in Type 2 Diabetes Are Sex-Specific and Associated with Serum Lipid Levels J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-30 Po-hung Wu, Gabby Joseph, Isra Saeed, Amir M. Pirmoazen, Katie Kenny, Tiffany Y. Kim, Anne L. Schafer, Ann V. Schwartz, Xiaojuan Li, Thomas M. Link, Galateia J. Kazakia
Type 2 diabetes (T2D) has negative effects on skeletal health. A proposed mechanism of diabetic bone disease connects hyperlipidemia to increased bone marrow adiposity and decreased bone quality. Previous research on Type 1 diabetes reported positive associations between serum lipid levels and marrow adiposity, but no data exist for T2D. In addition, marrow adiposity is sex-dependent in healthy populations
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An Exploration of Mineral Density, Elemental and Chemical Composition of Primary Teeth in Relation to Cord-Blood Vitamin D, Using Laboratory Analysis Techniques J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-25 Deanna M Beckett, Shaun Vaz Viegas, Jonathan M Broadbent, Benjamin J Wheeler, Kārlis Bērziņš, Sara J Fraser-Miller, Keith C Gordon, Bernadette K Drummond, Erin K Mahoney, Carolina Loch
Postnatally, severe vitamin D deficiency commonly results in rickets as well as potential defects in tooth mineralization. The effects of milder deficiency on oral health outcomes later in life are still unclear. This study used micro–computed tomography (μCT), energy dispersive X-ray analysis (EDX), and Raman spectroscopy to investigate mineral density, total density, and elemental composition of
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Acetyltransferases CBP/p300 Control Transcriptional Switch of β-Catenin and Stat1 Promoting Osteoblast Differentiation J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-18 Linlin Zhang, Kecheng Zhu, Jingzun Xu, Xiaojing Chen, Chunxiang Sheng, Deng Zhang, Yuying Yang, Lihao Sun, Hongyan Zhao, Xiao Wang, Bei Tao, Libin Zhou, Jianmin Liu
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Association of Bone Mineral Density and Bone Turnover Markers with the Risk of Diabetes: Hong Kong Osteoporosis Study and Mendelian Randomization J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-18 Xiaowen Zhang, Suhas Krishnamoorthy, Casey Tze-Lam Tang, Warrington Wen-Qiang Hsu, Gloria Hoi-Yee Li, Chor-Wing Sing, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Annie Wai-Chee Kung, Ching-Lung Cheung
Preclinical studies demonstrated that bone plays a central role in energy metabolism. However, how bone metabolism is related to the risk of diabetes in humans is unknown. We investigated the association of bone health (bone mineral density [BMD] and bone turnover markers) with incident type-2 diabetes mellitus (T2DM) based on the Hong Kong Osteoporosis Study (HKOS). A total of 993 and 7160 participants
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Quantifying Bone Strength Deficits in Young Adults Born Extremely Preterm or Extremely Low Birth Weight J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-18 Thang Dao, Dale Lee Robinson, Lex W Doyle, Peter VS Lee, Joy Olsen, Ashwini Kale, Jeanie LY Cheong, John D Wark
The long-term bone health of young adults born extremely preterm (EP; <28 weeks' gestation) or extremely low birth weight (ELBW; <1000 g birth weight) in the post-surfactant era (since the early 1990s) is unclear. This study investigated their bone structure and estimated bone strength using peripheral quantitative computed tomography (pQCT)-based finite element modeling (pQCT-FEM). Results using this
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Identifying Rare Genetic Determinants for Improved Polygenic Risk Prediction of Bone Mineral Density and Fracture Risk J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-13 Tianyuan Lu, Vincenzo Forgetta, Sirui Zhou, J Brent Richards, Celia MT Greenwood
Osteoporosis and fractures severely impact the elderly population. Polygenic risk scores for bone mineral density have demonstrated potential clinical utility. However, the value of rare genetic determinants in risk prediction has not been assessed. With whole-exome sequencing data from 436,824 UK Biobank participants, we assigned White British ancestry individuals into a training data set (n = 317
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Machine-Learning Assessed Abdominal Aortic Calcification is Associated with Long-Term Fall and Fracture Risk in Community-Dwelling Older Australian Women J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-12 Jack Dalla Via, Abadi K. Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim
Abdominal aortic calcification (AAC), a recognized measure of advanced vascular disease, is associated with higher cardiovascular risk and poorer long-term prognosis. AAC can be assessed on dual-energy X-ray absorptiometry (DXA)-derived lateral spine images used for vertebral fracture assessment at the time of bone density screening using a validated 24-point scoring method (AAC-24). Previous studies
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Efficacy and Toxicity of Calcitonin Treatment in Children with Cherubism: A Single-Center Cohort Study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-12 Willem H. Schreuder, Ethan B. Meijer, Arjen H.G. Cleven, Esther Edelenbos, Cornelis Klop, Ruud Schreurs, Renate T. de Jong, Merel C. van Maarle, Roy B.G. Horsthuis, Jan de Lange, Henk van den Berg
Cherubism is a rare autosomal dominant disease characterized by expansile osteolytic jawbone lesions. The effect and safety of off-label calcitonin treatment during the progressive phase of the disease are not well described. In this retrospective study, we present data on the radiological response and adverse effects of subcutaneously administered calcitonin in a cohort of nine cherubism children
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Maternal Smoking During Pregnancy and Offspring's Risk for Bone Fracture in Childhood and Adolescence J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-12 Emil Kääntä, Roope Parviainen, Marjaana Tikanmäki, Suvi Alenius, Juha-Jaakko Sinikumpu, Eero Kajantie
Conditions during gestation, such as maternal smoking, may affect offspring's bone structure. This could increase the offspring's risk of bone fractures during childhood. In this study, we aimed to assess the association between prenatal exposure to maternal smoking and childhood bone fracture risk. We used a register-based birth cohort that included all children born in Finland between January 1987
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Correction to “Dysregulated miR-98 Contributes to Extracellular Matrix Degradation by Targeting IL-6/STAT3 Signaling Pathway in Human Intervertebral Disc Degeneration” J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-11
Ji M, Lu J, Shi P, et al. Dysregulated miR-98 contributes to extracellular matrix degradation by targeting IL-6/STAT3 signaling pathway in human intervertebral disc degeneration. J Bone Miner Res. 2016;31(4):900–909. https://asbmr.onlinelibrary.wiley.com/doi/10.1002/jbmr.2753.
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Increased BMSi Association With Risk of Incident Osteoporotic Fractures. J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-10-01 Adolfo Diez-Perez,Cristian Tebé Cordomí,Erik Fink Eriksen,Julie A Pasco
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Effect of BMI-Discordant Abdominal Tissue Thickness on Fracture Probability: A Registry-Based Study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-30 William D. Leslie, Neil Binkley, John T. Schousboe, Eugene V. McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis
FRAX, which is used to assess fracture probability, considers body mass index (BMI), but BMI may not reflect individual variation in body composition and distribution. We examined the effect of BMI-discordant abdominal thickness on FRAX-derived fracture probability for major osteoporotic fracture (MOF) and hip fracture. We studied 73,105 individuals, mean age 64.2 years. During mean 8.7 years, 7048
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Breathing Easy for Better Bones: The Undervalued Role of Air Quality in Bone Health. J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-29 Andrea A Baccarelli,Diddier Prada
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Towards Improved Identification of Vertebral Fractures in Routine Computed Tomography (CT) Scans: Development and External Validation of a Machine Learning Algorithm J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-25 Joeri Nicolaes, Michael Kriegbaum Skjødt, Steven Raeymaeckers, Christopher Dyer Smith, Bo Abrahamsen, Thomas Fuerst, Marc Debois, Dirk Vandermeulen, Cesar Libanati
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VEGF Secretion Drives Bone Formation in Classical MAP2K1+ Melorheostosis J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-22 Jules D Allbritton-King, Jyotirindra Maity, Amit Patel, Robert A Colbert, Fatemeh Navid, Timothy Bhattacharyya
Patients with classical melorheostosis exhibit exuberant bone overgrowth in the appendicular skeleton, resulting in pain and deformity with no known treatment. Most patients have somatic, mosaic mutations in MAP2K1 (encoding the MEK1 protein) in osteoblasts and overlying skin. As with most rare bone diseases, lack of affected tissue has limited the opportunity to understand how the mutation results
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Opportunistic Screening With CT: Comparison of Phantomless BMD Calibration Methods J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-21 Stefan Bartenschlager, Alexander Cavallaro, Tobias Pogarell, Oliver Chaudry, Michael Uder, Sundeep Khosla, Georg Schett, Klaus Engelke
Opportunistic screening is a new promising technique to identify individuals at high risk for osteoporotic fracture using computed tomography (CT) scans originally acquired for an clinical purpose unrelated to osteoporosis. In these CT scans, a calibration phantom traditionally required to convert measured CT values to bone mineral density (BMD) is missing. As an alternative, phantomless calibration
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Syntaxin 18 Defects in Human and Zebrafish Unravel Key Roles in Early Cartilage and Bone Development J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-17 Brecht Guillemyn, Hanna De Saffel, Jan Willem Bek, Piyanoot Tapaneeyaphan, Adelbert De Clercq, Tamara Jarayseh, Sophie Debaenst, Andy Willaert, Riet De Rycke, Peter H Byers, Toon Rosseel, Paul Coucke, Bettina Blaumeiser, Delfien Syx, Fransiska Malfait, Sofie Symoens
SNARE proteins comprise a conserved protein family responsible for catalyzing membrane fusion during vesicle traffic. Syntaxin18 (STX18) is a poorly characterized endoplasmic reticulum (ER)-resident t-SNARE. Recently, together with TANGO1 and SLY1, its involvement was shown in ER to Golgi transport of collagen II during chondrogenesis. We report a fetus with a severe osteochondrodysplasia in whom we
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Active Vitamin D Use and Fractures in Hemodialysis Patients: Results from the International DOPPS J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-17 Hirotaka Komaba, Junhui Zhao, Angelo Karaboyas, Suguru Yamamoto, Indranil Dasgupta, Mohamed Hassan, Li Zuo, Anders Christensson, Christian Combe, Bruce M. Robinson, Masafumi Fukagawa
Active vitamin D is commonly used to control secondary hyperparathyroidism in dialysis patients, but it is unknown whether active vitamin D directly improves bone strength, independently of its ability to suppress parathyroid hormone (PTH). We analyzed the association between the prescription of active vitamin D and incidence of any fracture and hip fracture in 41,677 in-center hemodialysis patients
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The Added Value of High-Resolution Peripheral Quantitative Computed Tomography in Fracture Risk Prediction J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-13 Mattias Lorentzon, Andrew J. Burghardt
Disclosure Neither author has conflicts of interest to declare regarding the content of this manuscript.
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Dysregulation of MicroRNAs in Adult Osteogenesis Imperfecta: The miROI Study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-15 Alexandre Mercier-Guery, Marjorie Millet, Blandine Merle, Corinne Collet, Flora Bagouet, Olivier Borel, Elisabeth Sornay-Rendu, Pawel Szulc, Emmanuelle Vignot, Deborah Gensburger, Elisabeth Fontanges, Martine Croset, Roland Chapurlat
As epigenetic regulators of gene expression, circulating micro-RiboNucleic Acids (miRNAs) have been described in several bone diseases as potential prognostic markers. The aim of our study was to identify circulating miRNAs potentially associated with the severity of osteogenesis imperfecta (OI) in three steps. We have screened by RNA sequencing for the miRNAs that were differentially expressed in
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Reversible Effects of Puberty Suppression on Bone Strength, Mass, and Body Composition in Adolescent Mice After Testosterone Therapy J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-13 Ada S. Cheung
To the Editors: Concern regarding the deleterious bone effects of puberty suppression for transgender and gender diverse (trans) youth is an issue for patients, their families, and treating clinicians. Although there is considerable variability in access across jurisdictions, there has been an increase in demand for gender-affirming care for trans youth. Pubertal suppression with gonadotropin releasing
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Electrocardiogram Changes Following Intravenous Bisphosphonate Infusion: A Systematic Review and Meta-Analysis J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-09-08 Alex Shoung, Nicholas Shoung, Rachael Hii, Nitesh Nerlekar, Peter R Ebeling, Alexander J Rodríguez
Bisphosphonates are first-line treatments for several bone and mineral disorders. Studies have reported an increased incidence of serious atrial fibrillation in patients receiving bisphosphonates; however, uncertainty remains as to whether electrical disturbances are precipitated by bisphosphonates. We aimed to review the literature for studies reporting electrocardiogram (ECG) findings in patients
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Reply to the Submitted Comment Regarding our Publication "Increased Bone Material Strength Index Is Positively Associated With the Risk of Incident Osteoporotic Fractures in Older Swedish Women". J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-31 Raju Jaiswal,Michail Zoulakis,Kristian F Axelsson,Daniel Sundh,Henrik Litsne,Lisa Johansson,Mattias Lorentzon
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Prevention of Hip Fractures: Trade-off between Minor Benefits to Individuals and Large Benefits to the Community J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-28 Thach S. Tran, Thao P. Ho-Le, Dana Bliuc, Jacqueline R. Center, Robert D. Blank, Tuan V. Nguyen
Goeffrey Rose postulated that a population-based measure bringing a small benefit to each individual can yield large benefits to the community. We aimed to test this axiom by quantifying the relationship between change in bone mineral density (BMD) and hip fracture incidence between two prospective cohorts separated by ~10 years. In this prospective population-based Dubbo Osteoporosis Epidemiology
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Genetic Correlation, Shared Loci, and Causal Association Between Sex Hormone-Binding Globulin and Bone Mineral Density: Insights From a Large-Scale Genomewide Cross-Trait Analysis J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-24 Yang Qu, Changfeng Xiao, Xueyao Wu, Jingwei Zhu, Chenjiarui Qin, Lin He, Huijie Cui, Li Zhang, Wenqiang Zhang, Chunxia Yang, Yuqin Yao, Jiayuan Li, Zhenmi Liu, Ben Zhang, Wenzhi Wang, Xia Jiang
Although the impact of sex hormones on bone metabolism is well-documented, effect of their primary modulator, sex hormone-binding globulin (SHBG), remains inconclusive. This study aims to elucidate the genetic overlap between SHBG and heel estimated bone mineral density (eBMD), a widely-accepted tool for osteoporosis management and fracture risk assessment. Using summary statistics from large-scale
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Bacterial Lipopolysaccharides Exacerbate Neurogenic Heterotopic Ossification Development J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-21 Marjorie Salga, Selwin G Samuel, Hsu-Wen Tseng, Laure Gatin, Dorothée Girard, Bastien Rival, Valérie Barbier, Kavita Bisht, Svetlana Shatunova, Charlotte Debaud, Ingrid G Winkler, Julie Paquereau, Aurélien Dinh, Guillaume Genêt, Sébastien Kerever, Paer-Sélim Abback, Sébastien Banzet, François Genêt, Jean-Pierre Lévesque, Kylie A Alexander
Neurogenic heterotopic ossifications (NHO) are heterotopic bones that develop in periarticular muscles after severe central nervous system (CNS) injuries. Several retrospective studies have shown that NHO prevalence is higher in patients who suffer concomitant infections. However, it is unclear whether these infections directly contribute to NHO development or reflect the immunodepression observed
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Performance of Fracture Risk Assessment Tools by Race and Ethnicity: A Systematic Review for the ASBMR Task Force on Clinical Algorithms for Fracture Risk J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-19 Howard A. Fink, Mary E. Butler, Amy M. Claussen, Erin S. Collins, Kristina M. Krohn, Brent C. Taylor, Sina S. Tikabo, Denny Vang, Nicholas L. Zerzan, Kristine E. Ensrud
The American Society of Bone and Mineral Research (ASBMR) Professional Practice Committee charged an ASBMR Task Force on Clinical Algorithms for Fracture Risk to review the evidence on whether current approaches for differentiating fracture risk based on race and ethnicity are necessary and valid. To help address these charges, we performed a systematic literature review investigating performance of
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Cannabidiol and Cannabigerol, Nonpsychotropic Cannabinoids, as Analgesics that Effectively Manage Bone Fracture Pain and Promote Healing in Mice J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-19 Deepak Kumar Khajuria, Vengadeshprabhu Karuppagounder, Irena Nowak, Diana E. Sepulveda, Gregory S. Lewis, Christopher C. Norbury, Wesley M. Raup-Konsavage, Kent E. Vrana, Fadia Kamal, Reyad A. Elbarbary
Bone fractures are among the most prevalent musculoskeletal injuries, and pain management is an essential part of fracture treatment. Fractures heal through an early inflammatory phase, followed by repair and remodeling. Nonsteroidal anti-inflammatory drugs (NSAIDs) are not recommended for fracture pain control as they potently inhibit the inflammatory phase and, thus, impair the healing. Opioids do
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Burosumab Improves Patient-Reported Outcomes in Adults With Tumor-Induced Osteomalacia: Mixed-Methods Analysis J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-14 Suzanne M Jan de Beur, Tricia Cimms, Annabel Nixon, Christina Theodore-Oklota, Diana Luca, Mary Scott Roberts, Shayna Egan, Christina A Graham, Elizabeth Hribal, Christopher J Evans, Sue Wood, Angela Williams
Tumor-induced osteomalacia (TIO) is an ultra-rare disease caused by tumors that secrete fibroblast growth factor 23, leading to chronic hypophosphatemia, poor skeletal health, and impaired physical function. In a phase 2 trial (UX023T-CL201; NCT02304367; n = 14), 48 weeks of burosumab treatment restored phosphate homeostasis, with improvements in skeletal health, functional mobility, and patient-reported
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Fracture Risk in Patients with Anorexia Nervosa Over a 40-Year Period J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-14 Mette Søeby, Sigrid Bjerge Gribsholt, Loa Clausen, Bjørn Richelsen
Researchers have reported increased fracture risk in patients with anorexia nervosa (AN), but more knowledge on the long-term risk and the effects of age, male sex, and time-related changes is still needed. We examined the long-term (up to 40 years) fracture risk among patients with AN compared to a matched comparison cohort from the general population. We utilized data from the Danish Health Care
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Effects of Moderate- to High-Impact Exercise Training on Bone Structure Across the Lifespan: A Systematic Review and Meta-Analysis of Randomized Controlled Trials J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-09 Carrie-Anne Ng, Anoohya Gandham, Jakub Mesinovic, Patrick J Owen, Peter R Ebeling, David Scott
Moderate- to high-impact exercise improves bone mineral density (BMD) across the lifespan, but its effects on bone structure, which predicts fracture independent of areal BMD, are unclear. This systematic review and meta-analysis investigated effects of impact exercise on volumetric BMD (vBMD) and bone structure. Four databases (PubMed, Embase, SPORTDiscus, Web of Science) were searched up to March
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TMCO3, a Putative K+:Proton Antiporter at the Golgi Apparatus, Is Important for Longitudinal Growth in Mice and Humans J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-09 Tess Holling, Laura Brylka, Tasja Scholz, Tatjana Bierhals, Theresia Herget, Peter Meinecke, Thorsten Schinke, Ralf Oheim, Kerstin Kutsche
Isolated short stature, defined as short stature without any other abnormalities, is a common heterogeneous condition in children. Exome sequencing identified the homozygous nonsense variant c.1832G>A/p.(Trp611*) in TMCO3 in two sisters with isolated short stature. Radiological studies, biochemical measurements, assessment of the skeletal status, and three-dimensional bone microarchitecture revealed
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Osteocyte RANKL Drives Bone Resorption in Mouse Ligature-Induced Periodontitis J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-08 Mizuho Kittaka, Tetsuya Yoshimoto, Marcus E Levitan, Rina Urata, Roy B Choi, Yayoi Teno, Yixia Xie, Yukiko Kitase, Matthew Prideaux, Sarah L Dallas, Alexander G Robling, Yasuyoshi Ueki
Mouse ligature-induced periodontitis (LIP) has been used to study bone loss in periodontitis. However, the role of osteocytes in LIP remains unclear. Furthermore, there is no consensus on the choice of alveolar bone parameters and time points to evaluate LIP. Here, we investigated the dynamics of changes in osteoclastogenesis and bone volume (BV) loss in LIP over 14 days. Time-course analysis revealed
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Effect of Race/Ethnicity on United States FRAX Calculations and Treatment Qualification: A Registry-Based Study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-07 William D Leslie
Since 2008. the United States has had four race/ethnic fracture risk assessment tool (FRAX) calculators: White (“Caucasian”), Black, Asian, and Hispanic. The American Society for Bone and Mineral Research Task Force on Clinical Algorithms for Fracture Risk has been examining the implications of retaining race/ethnicity in the US FRAX calculators. To inform the Task Force, we computed FRAX scores according
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Buds of new bone formation within the Femoral Head of Hip Fracture Patients Coincide with Zones of Low Osteocyte Sclerostin J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-07 Hiroshige Sano, Tristan Whitmarsh, Linda Skingle, Taketoshi Shimakura, Noriaki Yamamoto, Juliet E. Compston, Hideaki E. Takahashi, Kenneth E. S. Poole
Romosozumab treatment reduces the rate of hip fractures and increases hip bone density, increasing bone formation by inhibiting sclerostin protein. We studied the normal pattern of bone formation and osteocyte expression in the human proximal femur because it is relevant to both antisclerostin treatment effects and fracture. Having visualized and quantified buds of new bone formation in trabeculae
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A Risk Assessment Tool for Predicting Fragility Fractures in People with HIV: Derivation and Internal Validation of the FRESIA Model J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-06 Pilar Vizcarra, Ana Moreno, María J. Vivancos, Alfonso Muriel García, Margarita Ramirez Schacke, Juan González-Garcia, Adrián Curran, Rosario Palacios, Antonio Jesús Sánchez Guirao, Sergio Reus Bañuls, Santiago Moreno Guillén, José L. Casado
People with HIV have a higher risk of fracture than the general population. Because of the low performance of the existing prediction tools, there is controversy surrounding fracture risk estimation in this population. The aim of the study was to develop a model for predicting the long-term risk of fragility fractures in people with HIV. We included 11,899 individuals aged ≥30 years from the Spanish
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GSTT1 as a Predictive Marker and Enhancer for Osteogenic Potential of Human Adipose-Derived Stromal/Stem Cells J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-03 Eugene Lee, Jae-Yeon Moon, Ji-Yun Ko, Seo-Young Park, Gun-Il Im
Adipose-derived stromal/stem cells (ASCs) have been extensively studied as cell sources for regenerative medicine for bone because of their excellent proliferative capacity and the ability to obtain a large number of cells with minimal donor morbidity. On the other hand, the differentiation potential of ASCs is generally lower than that of bone marrow-derived stromal/stem cells and varies greatly depending
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Periprosthetic Joint Infections of the Knee Lastingly Impact the Bone Homeostasis J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-03 Evgeniya Bandick, Lara Biedermann, Yi Ren, Stefanie Donner, Mario Thiele, Gabriela Korus, Serafeim Tsitsilonis, Michael Müller, Georg Duda, Carsten Perka, Arne Kienzle
After periprosthetic joint infection (PJI)-dependent revision surgery, a significantly elevated number of patients suffer from prosthesis failure due to aseptic loosening and require additional revision surgery despite clearance of the initial infection. The mechanisms underlying this pathology are not well understood, as it has been assumed that the bone stock recovers after revision surgery. Despite
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Vitamin D Metabolites Are Associated With Musculoskeletal Injury in Young Adults: A Prospective Cohort Study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-08-01 Alexander T Carswell, Thomas J O'Leary, Paul Swinton, Sarah Jackson, Jonathan CY Tang, Samuel J Oliver, Rachel M Izard, Neil P Walsh, William D Fraser, Julie P Greeves
The relationship between vitamin D metabolites and lower body (pelvis and lower limb) overuse injury is unclear. In a prospective cohort study, we investigated the association between vitamin D metabolites and incidence of lower body overuse musculoskeletal and bone stress injury in young adults undergoing initial military training during all seasons. In 1637 men and 530 women (aged 22.6 ± 7.5 years;
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Vitamin C Deficiency Deteriorates Bone Microarchitecture and Mineralization in a Sex-Specific Manner in Adult Mice J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-26 Stéphane Blouin, Farzaneh Khani, Phaedra Messmer, Paul Roschger, Markus A. Hartmann, Andre J. van Wijnen, Roman Thaler, Barbara M. Misof
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Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-22 Roger Bouillon, Meryl S LeBoff, Rachel E Neale
Vitamin D plays an important role in calcium homeostasis and many cellular processes. Although vitamin D supplements are widely recommended for community-dwelling adults, definitive data on whether these supplements benefit clinically important skeletal and extraskeletal outcomes have been conflicting. Although observational studies on effects of vitamin D on musculoskeletal and extraskeletal outcomes
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No Effect of NSAID Use on Efficacy of Zoledronate: A Post Hoc Analysis of a Randomized Trial in Osteopenic Older Women J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-21 Ian R Reid, Anne M Horne, Borislav Mihov, Sonja Bastin, Gregory D Gamble
Bisphosphonates are widely used for the prevention and treatment of osteoporosis. Nonsteroidal anti-inflammatory drugs (NSAIDs) are also widely used among the older population group at high risk of fractures. NSAIDs have been shown to impact on bone turnover, and a recent reanalysis of a clinical trial of clodronate found that NSAID use at baseline abrogated any effect of clodronate on either bone
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Lesion Expansion in Gnathic Fibrous Dysplasia: Natural History, Indicators of Progression, and Response to Bisphosphonates J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-21 Kristen S Pan, Jocelyn Taylor, Vivian Szymczuk, Alison M Boyce
Fibrous dysplasia (FD) is characterized by expansile fibro-osseous lesions that may occur in association with endocrinopathies as part of McCune–Albright syndrome (MAS). Craniofacial FD is a significant source of morbidity and most commonly involves the gnathic bones. There is a critical need to understand the natural history and risk factors for gnathic FD progression to develop preventative trials
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Hip Fractures and Aging: A Global Problem Requiring Coordinated Global Solutions. J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-20 Peter R Ebeling
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A Population-Based Registry Study of Extended Bisphosphonate Use: Minimal Shift After Landmark Publications About Shorter Treatment Duration J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-18 Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, William D. Leslie
Optimal duration of bisphosphonate therapy was unknown until the FLEX study was published in 2006 showing a 5-year course to be adequate for most women. In 2008, a link between long-term bisphosphonate and atypical femoral fractures was reported and confirmed in later studies. We hypothesized these landmark observations should have led to a decrease in use of bisphosphonates for >5 or 10 years, from
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Association Between Sarcopenia and Fracture Risk in a Population From the UK Biobank Database J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-17 Charlotte Jauffret, Renaud Périchon, Antoine Lamer, Bernard Cortet, Emmanuel Chazard, Julien Paccou
Studies on the fracture risk in presarcopenic and sarcopenic patients report contradictory results. The objective was to assess whether presarcopenia and sarcopenia are associated with an increase in fracture risk. We conducted a retrospective study using the UK Biobank cohort and the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. Muscle strength was evaluated using hand-grip
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Genetic and clinical screening for hereditary primary hyperparathyroidism in a large Chinese cohort: a single-center study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-14 An Song, Yi Yang, Yue Jiang, Min Nie, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing, Ou Wang
Primary hyperparathyroidism (PHPT) includes sporadic PHPT and hereditary PHPT. However, until now, there have been no exact data on the proportion and composition of hereditary PHPT in the Chinese PHPT population. This study aimed to clarify the proportion and composition of hereditary PHPT in patients at a large academic center in Beijing, China, and to analyze genotype–phenotype characteristics.
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Using Artificial Intelligence to Diagnose Osteoporotic Vertebral Fractures on Plain Radiographs J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-14 Li Shen, Chao Gao, Shundong Hu, Dan Kang, Zhaogang Zhang, Dongdong Xia, Yiren Xu, Shoukui Xiang, Qiong Zhu, GeWen Xu, Feng Tang, Hua Yue, Wei Yu, Zhenlin Zhang
Osteoporotic vertebral fracture (OVF) is a risk factor for morbidity and mortality in elderly population, and accurate diagnosis is important for improving treatment outcomes. OVF diagnosis suffers from high misdiagnosis and underdiagnosis rates, as well as high workload. Deep learning methods applied to plain radiographs, a simple, fast, and inexpensive examination, might solve this problem. We developed
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Evaluation of the Effect of Sodium-Glucose Cotransporter 2 Inhibition on Fracture Risk: Evidence From Mendelian Randomization and Genetic Association Study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-12 Huajie Dai, Longyi Zheng, Zheng Zhu, Xin Geng, Tianzhichao Hou, Qi Wang, Yijie Zhu, Hong Lin, Shuangyuan Wang, Ruizhi Zheng, Zhiyun Zhao, Mian Li, Jieli Lu, Yu Xu, Tiange Wang, Jianmin Liu, Guang Ning, Weiqing Wang, Yufang Bi, Jie Zheng, Min Xu
This study aims to evaluate the causal effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on bone mineral density (BMD), osteoporosis, and fracture risk using genetics. Two-sample Mendelian randomization (MR) analyses were performed utilizing two sets of genetic variants as instruments (six and two single-nucleotide polymorphisms [SNPs]) associated with SLC5A2 gene expression and glycated
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Single-Cell Transcriptomics of Bone Marrow Stromal Cells in Diversity Outbred Mice: A Model for Population-Level scRNA-Seq Studies J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-12 Luke J Dillard, Will T Rosenow, Gina M Calabrese, Larry D Mesner, Basel M Al-Barghouthi, Abdullah Abood, Emily A Farber, Suna Onengut-Gumuscu, Steven M Tommasini, Mark A Horowitz, Clifford J Rosen, Lutian Yao, Ling Qin, Charles R Farber
Genome-wide association studies (GWASs) have advanced our understanding of the genetics of osteoporosis; however, the challenge has been converting associations to causal genes. Studies have utilized transcriptomics data to link disease-associated variants to genes, but few population transcriptomics data sets have been generated on bone at the single-cell level. To address this challenge, we profiled
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3D Finite Element Models Reconstructed From 2D Dual-Energy X-Ray Absorptiometry (DXA) Images Improve Hip Fracture Prediction Compared to Areal BMD in Osteoporotic Fractures in Men (MrOS) Sweden Cohort J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-07 Lorenzo Grassi, Sami P. Väänänen, Lars Jehpsson, Östen Ljunggren, Björn E. Rosengren, Magnus K. Karlsson, Hanna Isaksson
Bone strength is an important contributor to fracture risk. Areal bone mineral density (aBMD) derived from dual-energy X-ray absorptiometry (DXA) is used as a surrogate for bone strength in fracture risk prediction tools. 3D finite element (FE) models predict bone strength better than aBMD, but their clinical use is limited by the need for 3D computed tomography and lack of automation. We have earlier
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Efficacy and Safety of Transdermal Abaloparatide in Postmenopausal Women with Osteoporosis: A Randomized Study J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-07 E. Michael Lewiecki, Edward Czerwinski, Chris Recknor, Anna Strzelecka, Guillermo Valenzuela, Mary Lawrence, Stuart Silverman, Jose Cardona, Susan M. Nattrass, Neil Binkley, Miriam Annett, Leny Pearman, Bruce Mitlak
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Measurements of the Vitamin D Metabolome in the Calgary Vitamin D Study: Relationship of Vitamin D Metabolites to Bone Loss J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-07-06 Lauren A. Burt, Martin Kaufmann, Marianne S. Rose, Glenville Jones, Emma O. Billington, Steven K. Boyd, David A. Hanley
In a 36-month randomized controlled trial examining the effect of high-dose vitamin D3 on radial and tibial total bone mineral density (TtBMD), measured by high-resolution peripheral quantitative tomography (HR-pQCT), participants (311 healthy males and females aged 55–70 years with dual-energy X-ray absorptiometry T-scores > −2.5 without vitamin D deficiency) were randomized to receive 400 IU (N = 109)
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Cortical and Trabecular Bone Deficit in Middle-Aged Men Living with HIV J. Bone Miner. Res. (IF 6.2) Pub Date : 2023-06-26 Namki Hong, Jung Ho Kim, Graham Treece, Hyeon Chang Kim, Jun Yong Choi, Yumie Rhee
A significant increase in the risk of hip fracture was observed in middle-aged men living with human immunodeficiency virus (MLWH), almost a decade earlier than those without infection. Data regarding cortical and trabecular bone deficit of hip, an important determinant of bone strength, in MLWH are limited. Quantitative CT was performed in consecutive MLWH aged ≥30 years between November 2017 and