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Bone health index in the assessment of bone health: The Generation R Study Bone (IF 4.1) Pub Date : 2024-03-07 Vid Prijatelj, Olja Grgic, André G. Uitterlinden, Eppo B. Wolvius, Fernando Rivadeneira, Carolina Medina-Gomez
Bone Health Index (BHI) has been proposed as a useful instrument for assessing bone health in children. However, its relationship with fracture risk remains unknown. We aimed to investigate whether BHI is associated with bone mineral density (BMD) and prevalent fracture odds in children from the Generation R Study. We also implemented genome-wide association study (GWAS) and polygenic score (PGS) approaches
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Influence of zoledronic acid and pamidronate on tooth eruption in children with osteogenesis imperfecta Bone (IF 4.1) Pub Date : 2024-03-06 Natalia Del Rio Cantero, María Rosa Mourelle Martínez, Belén Sagastizabal Cardelús, Joaquín Manuel De Nova García
Osteogenesis imperfecta (OI) is a congenital disease comprising a heterogeneous group of inherited connective tissue disorders. The main treatment in children is bisphosphonate therapy. Previous animal studies have shown that bisphosphonates delay tooth eruption. The aim of this study is to determine whether patients with OI treated with pamidronate and/or zoledronic acid have a delayed eruption age
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Pronounced cortical porosity and sex-specific patterns of increased bone and osteocyte lacunar mineralization characterize the human distal fibula with aging Bone (IF 4.1) Pub Date : 2024-03-06 Robin-Nicolas Hering, Simon von Kroge, Julian Delsmann, Alexander Simon, Benjamin Ondruschka, Klaus Püschel, Felix Nikolai Schmidt, Tim Rolvien
The high occurrence of distal fibula fractures among older women suggests a potential link to impaired bone health. Here we used a multiscale imaging approach to investigate the microarchitecture, mineralization, and biomechanics of the human distal fibula in relation to age and sex. Micro-computed tomography was performed to analyze the local volumetric bone mineral density and various microarchitectural
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Cognitive function and skeletal size and mineral density at age 6–7 years: Findings from the Southampton Women's Survey Bone (IF 4.1) Pub Date : 2024-03-02 Rebecca J. Moon, Stefania D'Angelo, Sarah R. Crozier, Michelle Fernandes, Caroline Fall, Catharine R. Gale, Keith M. Godfrey, Justin H. Davies, Cyrus Cooper, Nicholas C. Harvey
Poor cognitive function and osteoporosis commonly co-exist in later life. In women, this is often attributed to post-menopausal estrogen loss. However, a common early life origin for these conditions and the associations between cognitive function and bone mineral density (BMD) in childhood have not previously been explored. We examined these relationships at age 6–7 years in the Southampton Women's
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PPI use is not associated with bone microarchitecture and strength assessed with HR-pQCT after three-years follow-up in patients visiting the Fracture Liaison Service Bone (IF 4.1) Pub Date : 2024-03-02 M.R. Schene, M.S.A.M. Bevers, W.J.F. van der Vijgh, J.H.M. Driessen, L. Vranken, R.Y. van der Velde, H.C. Willems, C.E. Wyers, J.P. van den Bergh
The use of proton pump inhibitors (PPIs) has been associated with an increased fracture risk in observational studies. However, the reported association between PPI use and bone mineral density (BMD), bone microarchitecture, and bone strength is inconsistent. This study aims to assess the association between PPI use and bone microarchitecture and strength using high-resolution peripheral quantitative
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Unraveling the transcriptome profile of pulsed electromagnetic field stimulation in bone regeneration using a bioreactor-based investigation platform Bone (IF 4.1) Pub Date : 2024-02-28 Farah Daou, Beatrice Masante, Stefano Gabetti, Federico Mochi, Giovanni Putame, Eleonora Zenobi, Elisa Scatena, Federica Dell'Atti, Francesco Favero, Massimiliano Leigheb, Costantino Del Gaudio, Cristina Bignardi, Diana Massai, Andrea Cochis, Lia Rimondini
Human mesenchymal stem cells (hMSCs) sense and respond to biomechanical and biophysical stimuli, yet the involved signaling pathways are not fully identified. The clinical application of biophysical stimulation including pulsed electromagnetic field (PEMF) has gained momentum in musculoskeletal disorders and bone tissue engineering. We herein aim to explore the role of PEMF stimulation in bone regeneration
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Familial cases with adult-onset FGF23-related hypophosphatemic osteomalacia -A PHEX 3’-UTR change as a possible cause- Bone (IF 4.1) Pub Date : 2024-02-25 Shun Sawatsubashi, Yuichi Takashi, Itsuro Endo, Takeshi Kondo, Masahiro Abe, Toshio Matsumoto, Seiji Fukumoto
Excessive actions of FGF23 cause several kinds of hypophosphatemic rickets/osteomalacia. It is possible that there still remain unknown causes or mechanisms for FGF23-elated hypophosphatemic diseases. We report two male cousins who had been suffering form FGF23-related hypophosphatemic osteomalacia. Sequencing of exons and exon-intron junctions of known causative genes for FGF23-related hypophosphatemic
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Chondrocyte hypertrophy in the growth plate promotes stress anisotropy affecting long bone development through chondrocyte column formation Bone (IF 4.1) Pub Date : 2024-02-25 Yuka Yokoyama, Yoshitaka Kameo, Junko Sunaga, Koichiro Maki, Taiji Adachi
The length of long bones is determined by column formation of proliferative chondrocytes and subsequent chondrocyte hypertrophy in the growth plate during bone development. Despite the importance of mechanical loading in long bone development, the mechanical conditions of the cells within the growth plate, such as the stress field, remain unclear owing to the difficulty in investigating spatiotemporal
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DDIT3 deficiency accelerates bone remodeling during bone healing by enhancing osteoblast and osteoclast differentiation through ULK1-mediated autophagy Bone (IF 4.1) Pub Date : 2024-02-24 Meie Jia, Zhipeng Dong, Wei Dong, Beining Yang, Ying He, Yan Wang, Jiawei Wang
The coordination of osteoblasts and osteoclasts is essential for bone remodeling. DNA damage inducible script 3 (DDIT3) is an important regulator of bone and participates in cell differentiation, proliferation, autophagy, and apoptosis. However, its role in bone remodeling remains unexplored. Here, we found that knockout (-KO) enhanced both bone formation and resorption. The increased new bone formation
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Crosstalk between ALK3(BMPR1A) deficiency and autophagy signaling mitigates pathological bone loss in osteoporosis Bone (IF 4.1) Pub Date : 2024-02-24 Zhixing Niu, Yumeng Zhou, Muchun Liang, Fuqiang Su, Qiang Guo, Junjun Jing, Jing Xie, Demao Zhang, Xiaoheng Liu
Postmenopausal osteoporosis is recognized to be one of the major skeleton diseases strongly associated with impaired bone formation. Previous reports have indicated that the importance of bone morphogenetic protein (BMP) signaling of osteoblast lineage in bone development via classical Smad signaling, however, its critical role in osteoporosis is still not well understood. In the current study, we
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Abaloparatide promotes bone repair of vertebral defects in ovariectomized rats by increasing bone formation Bone (IF 4.1) Pub Date : 2024-02-23 Akito Makino, Tomoka Hasegawa, Tomomaya Yamamoto, Hideko Takagi, Yoshimasa Takahashi, Naohisa Miyakoshi, Norio Amizuka
Osteoporotic vertebral fracture (OVF) is the most common type of osteoporotic fracture and is associated with immobility and mortality. Bone anabolic agents, such as abaloparatide (ABL), are usually administered to patients with OVF to prevent subsequent fractures. Although several studies have shown that bone anabolic agents promote healing of long bone fractures, there is little evidence of their
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Cancer risk in patients treated with denosumab compared with alendronate: A population-based cohort study Bone (IF 4.1) Pub Date : 2024-02-21 Sam Kafai Yahyavi, Rune Holt, Nadia Krarup Knudsen, Christine Hjorth Andreassen, Christoffer Sejling, Alessandra Meddis, Susanne K. Kjaer, Peter Schwarz, Jens-Erik Beck Jensen, Christian Torp-Pedersen, Anders Juul, Christian Selmer, Martin Blomberg Jensen
Antiresorptive treatment is currently used in millions of patients with osteoporosis and cancer worldwide. Early studies of denosumab suggested a small signal in ovarian cancer incidence and emerging data suggest that denosumab stimulates germ cell proliferation in the gonads. This study aims to determine the association between the use of denosumab and the risk of reproductive cancers compared with
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Influence of microarchitecture on stressed volume and mechanical fatigue behaviour of equine subchondral bone Bone (IF 4.1) Pub Date : 2024-02-21 Andrew Koshyk, Andrew J. Pohl, Yuji Takahashi, W. Michael Scott, Holly D. Sparks, W. Brent Edwards
Fractures of the equine metacarpophalangeal (MCP) joint are among the most common and fatal injuries experienced by racehorses. These bone injuries are a direct result of repetitive, high intensity loading of the skeleton during racing and training and there is consensus that they represent a mechanical fatigue phenomenon. Existing work has found the fatigue life of bone to be strongly determined by
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DXA-based statistical models of shape and intensity outperform aBMD hip fracture prediction: A retrospective study Bone (IF 4.1) Pub Date : 2024-02-20 Alessandra Aldieri, Margaret Paggiosi, Richard Eastell, Cristina Bignardi, Alberto L. Audenino, Pinaki Bhattacharya, Mara Terzini
Areal bone mineral density (aBMD) currently represents the clinical gold standard for hip fracture risk assessment. Nevertheless, it is characterised by a limited prediction accuracy, as about half of the people experiencing a fracture are not classified as at being at risk by aBMD. In the context of a progressively ageing population, the identification of accurate predictive tools would be pivotal
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Osteocalcin improves glucose tolerance, insulin sensitivity and secretion in older male mice Bone (IF 4.1) Pub Date : 2024-02-18 Noorulain Paracha, Paul Mastrokostas, Evan Kello, Yosef Gedailovich, Devorah Segall, Alexis Rizzo, Lawrence Mitelberg, Naif Hassan, Terry Lynne Dowd
Osteocalcin deficient mice (OC-/-), on a mixed 129/BL6J background, were reported to show glucose intolerance, insulin insensitivity and reduced insulin secretion at 1-6 mos of age. This is controversial as two studies in OC-/- mice on different backgrounds (C3H/BL6 (5-6 mos.) and C57BL/6N (5 and 9 mos.)) found no effect on glucose metabolism. To determine the role of OC in glucose metabolism we conducted
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TNF-α promotes osteocyte necroptosis by upregulating TLR4 in postmenopausal osteoporosis Bone (IF 4.1) Pub Date : 2024-02-15 Hongwang Cui, Ji Li, Xiangtao Li, Tian Su, Peng Wen, Chuanling Wang, Xiaozhong Deng, Yonghua Fu, Weijie Zhao, Changjia Li, Pengbing Hua, Yongjun Zhu, Wei Wan
Postmenopausal osteoporosis (PMOP) is a common kind of osteoporosis that is associated with excessive osteocyte death and bone loss. Previous studies have shown that TNF-α-induced osteocyte necroptosis might exert a stronger effect on PMOP than apoptosis, and TLR4 can also induce cell necroptosis, as confirmed by recent studies. However, little is known about the relationship between TNF-α-induced
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Successful treatment approaches for tumoral calcinosis in children and young people: A condition of diverse pathogenesis Bone (IF 4.1) Pub Date : 2024-02-15 A. Anilkumar, W. Högler, J. Bursell, R. Nadar, F. Ryan, T. Randell, N.J. Shaw, S. Uday
Ectopic calcification is inappropriate biomineralization of soft tissues occurring due to genetic or acquired causes of hyperphosphataemia and rarely in normophosphataemic individuals. Tumoral Calcinosis (TC) is a rare metabolic bone disorder commonly presenting in childhood and adolescence with periarticular extra-capsular calcinosis. Three subtypes of TC have been recognised: primary hyperphosphataemic
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Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice Bone (IF 4.1) Pub Date : 2024-02-13 Silvia Marino, Serra Ucer Ozgurel, Kevin McAndrews, Meloney Cregor, Alma Villaseñor, Maricuz Mamani-Huanca, Coral Barbas, Arancha Gortazar, Amy Y. Sato, Teresita Bellido
This study investigated the efficacy of the two FDA-approved bone anabolic ligands of the parathyroid hormone receptor 1 (PTH1R), teriparatide or human parathyroid hormone 1–34 (PTH) and abaloparatide (ABL), to restoring skeletal health using a preclinical murine model of streptozotocin-induced T1-DM. Intermittent daily subcutaneous injections of equal molar doses (12 pmoles/g/day) of PTH (50 ng/g/day)
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Epigenetic regulators controlling osteogenic lineage commitment and bone formation Bone (IF 4.1) Pub Date : 2024-02-09 Parisa Dashti, Eric A. Lewallen, Jonathan A.R. Gordon, Martin A. Montecino, James R. Davie, Gary S. Stein, Johannes P.T.M. van Leeuwen, Bram C.J. van der Eerden, Andre J. van Wijnen
Bone formation and homeostasis are controlled by environmental factors and endocrine regulatory cues that initiate intracellular signaling pathways capable of modulating gene expression in the nucleus. Bone-related gene expression is controlled by nucleosome-based chromatin architecture that limits the accessibility of lineage-specific gene regulatory DNA sequences and sequence-specific transcription
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Human osteoclasts in vitro are dose dependently both inhibited and stimulated by cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) Bone (IF 4.1) Pub Date : 2024-02-09 Simone S.R. Nielsen, Juliana A.Z. Pedersen, Neha Sharma, Pernille K. Wasehuus, Morten S. Hansen, Anaïs M.J. Møller, Xenia G. Borggaard, Alexander Rauch, Morten Frost, Teis E. Sondergaard, Kent Søe
Legalized use of cannabis for medical or recreational use is becoming more and more common. With respect to potential side-effects on bone health only few clinical trials have been conducted – and with opposing results. Therefore, it seems that there is a need for more knowledge on the potential effects of cannabinoids on human bone cells. We studied the effect of cannabidiol (CBD) and Δ9-tetrahydrocannabinol
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Sustained hypophosphatemia after denosumab in a patient on hemodialysis Bone (IF 4.1) Pub Date : 2024-02-08 Ahmed A.S. Almodares, Grahame J. Elder, Bo Abrahamsen
An 81-year-old Caucasian man who had commenced thrice weekly hemodialysis (HD) three months earlier, presented with a hip fracture, two vertebral fractures and a bone mineral density T-score of −3.6. He had received weekly iron sucrose infusions for 6 weeks and alphacalcidol on dialysis days. Although he suffered from coeliac disease and cirrhosis, he was fully ambulatory and well-nourished. He was
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Cutaneous burn injury represents a major risk factor for the development of traumatic ectopic bone formation following blast-related extremity injury Bone (IF 4.1) Pub Date : 2024-02-07 Cassie J. Rowe, Uloma Nwaolu, Daniela Salinas, Jefferson L. Lansford, Conor F. McCarthy, Joseph A. Anderson, Michael S. Valerio, Benjamin K. Potter, Philip J. Spreadborough, Thomas A. Davis
Blast-related traumatic heterotopic ossification (tHO) impacts clinical outcomes in combat-injured patients, leading to delayed wound healing, inflammatory complications, and reduced quality of life. Blast injured patients often have significant burns. This study investigated whether a partial thickness thermal burn injury exacerbates blast-related tHO in a clinically relevant polytrauma animal model
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A pathogenic role for brain-derived neurotrophic factor (BDNF) in fibrous dysplasia of bone Bone (IF 4.1) Pub Date : 2024-02-07 Biagio Palmisano, Giorgia Farinacci, Federica Campolo, Chiara Tavanti, Alessia Stefano, Samantha Donsante, Ernesto Ippolito, Giuseppe Giannicola, Mary Anna Venneri, Alessandro Corsi, Mara Riminucci
Brain derived neurotrophic factor (BDNF) is a neurotrophin, expressed in the central nervous system and in peripheral tissues, that is regulated by the Gsα/cAMP pathway. In bone, it regulates osteogenesis and stimulates RANKL secretion and osteoclast formation in osteolytic tumors such as Multiple Myeloma. Fibrous dysplasia (FD) of bone is a rare genetic disease of the skeleton caused by gain-of-function
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Compromised femoral and lumbovertebral bone in the Dp(16)1Yey Down syndrome mouse model Bone (IF 4.1) Pub Date : 2024-02-07 Joshua Lamantia, Kourtney Sloan, Joseph M. Wallace, Randall J. Roper
Down syndrome (DS), affecting ∼1 in 800 live births, is caused by the triplication of human chromosome 21 (Hsa21). Individuals with DS have skeletal features including craniofacial abnormalities and decreased bone mineral density (BMD). Lowered BMD can lead to increased fracture risk, with common fracture points at the femoral neck and lumbar spine. While the femur has been studied in DS mouse models
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Transitions - Sundeep Khosla, M.D., Editor-In-Chief for Bone, 2013-2023 Bone (IF 4.1) Pub Date : 2024-02-06 S, u, n, d, e, e, p, , K, h, o, s, l, a
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Complex intrinsic abnormalities in osteoblast lineage cells of X-linked hypophosphatemia: Analysis of human iPS cell models generated by CRISPR/Cas9-mediated gene ablation Bone (IF 4.1) Pub Date : 2024-02-06 Tatsuro Nakanishi, Miwa Yamazaki, Kanako Tachikawa, Ayu Ueta, Masanobu Kawai, Keiichi Ozono, Toshimi Michigami
X-linked hypophosphatemia (XLH) is caused by inactivating variants of the () gene. Although the overproduction of fibroblast growth factor 23 (FGF23) is responsible for hypophosphatemia and impaired vitamin D metabolism, the pathogenesis of XLH remains unclear. We herein generated -knockout (KO) human induced pluripotent stem (iPS) cells by applying CRISPR/Cas9-mediated gene ablation to an iPS clone
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Impact of heavy alcohol consumption on cortical bone mechanical properties in male rhesus macaques Bone (IF 4.1) Pub Date : 2024-02-05 Mihee Shin, Do Kyung Kim, Manish Jain, Penny J. Martens, Russell T. Turner, Urszula T. Iwaniec, Jamie J. Kruzic, Bernd Gludovatz
Chronic heavy alcohol consumption may influence the skeleton by suppressing intracortical bone remodeling which may impact the quality of bone and its mechanical properties. However, this aspect has not been thoroughly assessed in either humans or animal models whose cortical bone microstructure resembles the microstructure of human cortical bone. The current study is the first to investigate the effects
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Bone microarchitectural alterations associated with spinal cord injury: Relation to sex hormones, metabolic factors, and loading Bone (IF 4.1) Pub Date : 2024-02-05 Rodrigo J. Valderrábano, Karol Pencina, Yili-Valentine Shang, Evelyn Echevarria, Robert Dixon, Catherine Ghattas, Lauren Wilson, Kieran F. Reid, Thomas Storer, Margaret Garrahan, Trinity Tedtsen, Ross Zafonte, Mary Bouxsein, Shalender Bhasin
People living with spinal cord injury (SCI) are at high risk for bone fractures. Neural, hormonal and metabolic contributors to bone microarchitectural alterations are incompletely understood. To determine the relationship of physical, metabolic and endocrine characteristics with bone microarchitecture, characterized using high-resolution peripheral quantitative computed tomography (HRpQCT) in SCI
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Iguratimod suppresses sclerostin and receptor activator of NF-κB ligand production via the extracellular signal–regulated kinase/early growth response protein 1/tumor necrosis factor alpha pathway in osteocytes and ameliorates disuse osteoporosis in mice Bone (IF 4.1) Pub Date : 2024-02-05 Taihei Miura, Yuki Etani, Takaaki Noguchi, Makoto Hirao, Kenji Takami, Atsushi Goshima, Takuya Kurihara, Yuji Fukuda, Nagahiro Ochiai, Takashi Kanamoto, Ken Nakata, Seiji Okada, Kosuke Ebina
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Tmem119 is involved in bone anabolic effects of PTH through enhanced osteoblastic bone formation in mice Bone (IF 4.1) Pub Date : 2024-02-04 Naoyuki Kawao, Daichi Matsumura, Ayaka Yamada, Katsumi Okumoto, Takashi Ohira, Yuya Mizukami, Daiki Hashimoto, Hiroshi Kaji
The intermittent administration of parathyroid hormone (PTH) exerts potent bone anabolic effects, which increase bone mineral density (BMD) and reduce fracture risk in osteoporotic patients. However, the underlying mechanisms remain unclear. Tmem119 has been proposed as a factor that is closely linked to the osteoblast phenotype, and we previously reported that PTH enhanced the expression of Tmem119
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The role of Map1b in regulating osteoblast polarity, proliferation, differentiation and migration Bone (IF 4.1) Pub Date : 2024-02-03 Li Peng, Demao Zhang, Heng Tu, Dan Wu, Shuaixi Xiang, Wenbin Yang, Yun Zhao, Jing Yang
Osteoblast polarity, proliferation, differentiation, and migration are essential for maintaining normal bone structure and function. While the microtubule-associated protein Map1b has been extensively studied in nerve cells, its role in bone cells is less known. We investigated the functional significance of Map1b in mouse bone marrow stromal cells (ST2) and elucidated its relationship and influence
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S-nitrosoglutathione reductase-dependent p65 denitrosation promotes osteoclastogenesis by facilitating recruitment of p65 to NFATc1 promoter Bone (IF 4.1) Pub Date : 2024-02-02 Shumin Liu, Qian Lu, Min Wang, Huilin Guo, Yiwen Wang, Jingwen Nong, Shuo Wang, Haibin Xia, Ting Xia, Huifang Sun
Osteoclasts, the exclusive bone resorptive cells, are indispensable for bone remodeling. Hence, understanding novel signaling modulators regulating osteoclastogenesis is clinically important. Nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) is a master transcription factor in osteoclastogenesis, and binding of NF-κB p65 subunit to NFATc1 promoter is required for its expression. It is well-established
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Controlled mechanical loading affects the osteocyte transcriptome in porcine trabecular bone in situ Bone (IF 4.1) Pub Date : 2024-02-02 Meghana Machireddy, Alyssa G. Oberman, Lucas DeBiase, Melissa Stephens, Jun Li, Laurie E. Littlepage, Glen L. Niebur
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Accuracy of photon-counting computed tomography for the measurement of bone quality in the knee Bone (IF 4.1) Pub Date : 2024-02-02 Fahimeh Azari, Piyush Uniyal, Jeroen Soete, Walter Coudyzer, Caroline E. Wyers, Jilmen Quintiens, Joop P. van den Bergh, G. Harry van Lenthe
Visualization and quantification of bone microarchitecture in the human knee allows gaining insight into normal bone structure, and into the structural changes occurring in the onset and progression of bone diseases such as osteoporosis and osteoarthritis. However, current imaging modalities have limitations in capturing the intricacies of bone microarchitecture. Photon counting computed tomography
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A comprehensive set of ultrashort echo time magnetic resonance imaging biomarkers to assess cortical bone health: A feasibility study at clinical field strength Bone (IF 4.1) Pub Date : 2024-02-02 Andrea M. Jacobson, Xuandong Zhao, Stefan Sommer, Farhan Sadik, Stuart J. Warden, Christopher Newman, Thomas Siegmund, Matthew R. Allen, Rachel K. Surowiec
Conventional bone imaging methods primarily use X-ray techniques to assess bone mineral density (BMD), focusing exclusively on the mineral phase. This approach lacks information about the organic phase and bone water content, resulting in an incomplete evaluation of bone health. Recent research highlights the potential of ultrashort echo time magnetic resonance imaging (UTE MRI) to measure cortical
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Health-related quality of life and fatigue in adult rare bone disease patients: A cross-sectional study from Austria Bone (IF 4.1) Pub Date : 2024-02-02 Martina Behanova, Amadea Medibach, Judith Haschka, Daniel Kraus, Adalbert Raimann, Gabriel T. Mindler, Jochen Zwerina, Roland Kocijan
To assess physical and mental health domains of health related quality of life (HRQoL) as well as fatigue in rare bone disease (RBD) patients and to compare to patients with osteoporosis (OPO) and healthy controls (CTRL) without known bone diseases and to study associations of Fatique Severity Scale (FSS) with eight domains of HRQoL. Monocentric, cross-sectional study carried out between 2020 and 2022
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Exposure to low humidex increases the risk of hip fracture admissions in a subtropical coastal Chinese city Bone (IF 4.1) Pub Date : 2024-02-01 Yanhu Ji, Zepeng Huang, Zhongjia Yuan, Jianping Xiong, Liping Li
The adverse impacts of meteorological factors on human health have attracted great attention. However, no studies have investigated the nonlinear effects of humidex on hip fractures (HF), particularly in middle-aged and older adults. This study aimed to quantify the impacts of humidex, a comprehensive index of temperature and relative humidity, on HF admissions. Daily HF admissions, meteorological
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Anti-sclerostin antibody therapy prevents post-ischemic osteonecrosis bone collapse via interleukin-6 association Bone (IF 4.1) Pub Date : 2024-02-01 Yuto Ozawa, Yasuhiko Takegami, Yusuke Osawa, Takamune Asamoto, Shinya Tanaka, Shiro Imagama
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Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B6 metabolism Bone (IF 4.1) Pub Date : 2024-02-01 Michael P. Whyte, Fan Zhang, Karen E. Mack, Deborah Wenkert, Gary S. Gottesman, Karen L. Ericson, Jeffrey T. Cole, Stephen P. Coburn
Alkaline phosphatase (ALP) is detected in most human tissues. However, ALP activity is routinely assayed using high concentrations of artificial colorimetric substrates in phosphate-free laboratory buffers at lethal pH. Hypophosphatasia (HPP) is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of the gene that encodes the ALP isoenzyme expressed in bone, liver, kidney, and elsewhere
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Association between physical activity, sedentary behavior patterns with bone health among Chinese older women Bone (IF 4.1) Pub Date : 2024-01-23 Xiaoyu Ren, Chuan Hu, Wenbo Wang, Qiang He, Litao Du, Ting Li, Yang Pan, Si Chen, Xianliang Zhang
We examined the association between physical activity (PA) and sedentary behavior (SEB) time with bone health and whether it changes depending on different patterns. Cross-sectional data were derived from the baseline of the Physical Activity and Health in Older Women Study. PA and SEB were measured using Actigraph wGT3X-BT accelerometers. Bone mineral density (BMD) was derived from the SONOST-2000
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Adaptive enhancement of apatite crystal orientation and Young's modulus under elevated load in rat ulnar cortical bone Bone (IF 4.1) Pub Date : 2024-01-23 Jun Wang, Takuya Ishimoto, Tadaaki Matsuzaka, Aira Matsugaki, Ryosuke Ozasa, Takuya Matsumoto, Mikako Hayashi, Hyoung Seop Kim, Takayoshi Nakano
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Is there a role for N1-N2 neutrophil phenotypes in bone regeneration? A systematic review Bone (IF 4.1) Pub Date : 2024-01-20 Fangzhou Lu, Samai M.N.E. Verleg, Rald V.M. Groven, Martijn Poeze, Martijn van Griensven, Taco J. Blokhuis
This review aims to provide an overview of the multiple functions of neutrophils, with the recognition of the inflammatory (N1) and regenerative (N2) phenotypes, in relation to fracture healing. A literature search was performed using the PubMed database. The quality of the articles was evaluated using critical appraisal checklists. Thirty one studies were included in this review. These studies consistently
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The molecular complexity of COL2A1 splicing variants and their significance in phenotype severity Bone (IF 4.1) Pub Date : 2024-01-19 I. Viakhireva, I. Bychkov, T. Markova, O. Shatokhina, K. Karandasheva, V. Udalova, Y. Bekhtereva, O. Ryzhkova, M. Skoblov
Pathogenic single nucleotide variants (SNVs) found in the gene are associated with a broad range of skeletal dysplasias due to their impact on the structure and function of the Col2a1 protein. However, the molecular mechanisms of some nucleotide variants detected during diagnostic testing remain unclear. The interpretation of missense and splicing variants caused by SNVs poses a significant challenge
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Runx2 deletion in hypertrophic chondrocytes impairs osteoclast mediated bone resorption Bone (IF 4.1) Pub Date : 2024-01-12 Harunur Rashid, Caris M. Smith, Vashti Convers, Katelynn Clark, Amjad Javed
Deletion of Runx2 gene in proliferating chondrocytes results in complete failure of endochondral ossification and perinatal lethality. We reported recently that mice with Runx2 deletion specifically in hypertrophic chondrocytes (HCs) using the Col10a1-Cre transgene survive and exhibit enlarged growth plates due to decreased HC apoptosis and cartilage resorption. Bulk of chondrogenesis occurs postnatally
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Hormonal contraceptive use is associated with altered bone structural and metabolic responses to military training in women: An observational cohort study Bone (IF 4.1) Pub Date : 2024-01-11 Thomas J. O'Leary, Rachel M. Izard, Jonathan C.Y. Tang, William D. Fraser, Julie P. Greeves
Military training increases tibial density and size. Female sex hormones may influence the adaption of bone to loading, but it is unknown if women using different hormonal contraceptives adapt similarly to military training. One hundred and sixteen women (57 women not using hormonal contraceptives [non-users], 38 combined oral contraceptive pill [COCP] users, 21 depot medroxyprogesterone acetate [DMPA]
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How osteons form: A quantitative hypothesis-testing analysis of cortical pore filling and wall asymmetry Bone (IF 4.1) Pub Date : 2024-01-04 Solene G.D. Hegarty-Cremer, Xenia G. Borggaard, Christina M. Andreasen, Bram C.J. van der Eerden, Matthew J. Simpson, Thomas L. Andersen, Pascal R. Buenzli
Osteon morphology provides valuable information about the interplay between different processes involved in bone remodelling. The correct quantitative interpretation of these morphological features is challenging due to the complexity of interactions between osteoblast behaviour, and the evolving geometry of cortical pores during pore closing. We present a combined experimental and mathematical modelling
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Corrigendum to “G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development” [Bone 137 (2020) 115332] Bone (IF 4.1) Pub Date : 2024-01-02 Hisashi Ideno, Kazuhisa Nakashima, Koichiro Komatsu, Ryoko Araki, Masumi Abe, Yoshinori Arai, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji
Abstract not available
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Restoring implant fixation strength in osteoporotic bone with a hydrogel locally delivering zoledronic acid and bone morphogenetic protein 2. A longitudinal in vivo microCT study in rats Bone (IF 4.1) Pub Date : 2024-01-02 Claudia Siverino, Laura Tirkkonen-Rajasalo, Linda Freitag, Christian Günther, Keith Thompson, Ursula Styger, Stephan Zeiter, David Eglin, Vincent A. Stadelmann
Osteoporosis poses a major public health challenge, and it is characterized by low bone mass, deterioration of the microarchitecture of bone tissue, causing a consequent increase in bone fragility and susceptibility to fractures and complicating bone fixation, particularly screw implantation. In the present study, our aim was to improve implant stability in osteoporotic bone using a thermoresponsive
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Corrigendum to “Multiscale mechanical responses of young and elderly human femurs: A finite element investigation” [Bone 153(2021) 116125] Bone (IF 4.1) Pub Date : 2023-12-30 Haipeng Cen, Yan Yao, Haibo Liu, Shaowei Jia, He Gong
Abstract not available
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Fracture patterns and associated risk factors in pediatric and early adulthood type 1 diabetes: Findings from a nationwide retrospective cohort study Bone (IF 4.1) Pub Date : 2023-12-27 Nicklas H. Rasmussen, Johanna H.M. Driessen, Annika Vestergaard Kvist, Patrick C. Souverein, Joop P. van den Bergh, Peter Vestergaard
Purpose People with pediatric and early adulthood type 1 diabetes (T1D) might have a higher fracture risk at several sites compared to the general population. Therefore, we assessed the hazard ratios (HR) of various fracture sites and determined the risk factors associated with fractures among people with newly diagnosed childhood and adolescence T1D. Methods All people from the UK Clinical Practice
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Quantitative 31P magnetic resonance imaging on pathologic rat bones by ZTE at 7T Bone (IF 4.1) Pub Date : 2023-12-27 Victor B. Kassey, Matthias Walle, Jonathan Egan, Diana Yeritsyan, Indeevar Beeram, Yaotang Wu, Brian D. Snyder, Edward K. Rodriguez, Jerome L. Ackerman, Ara Nazarian
Background Osteoporosis is characterized by low bone mineral density (BMD), which predisposes individuals to frequent fragility fractures. Quantitative BMD measurements can potentially help distinguish bone pathologies and allow clinicians to provide disease-relieving therapies. Our group has developed non-invasive and non-ionizing magnetic resonance imaging (MRI) techniques to measure bone mineral
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Response to letter to the editor regarding, “Depletion of macrophages deteriorates bisphosphonate-related osteonecrosis of the jaw-like lesions in mice” Bone (IF 4.1) Pub Date : 2023-12-29 Rhyohei Kozutsumi, Shinichiro Kuroshima, Farah A. Al-Omari, Hiroki Hayano, Kazunori Nakajima, Hiroe Kakehashi, Takashi Sawase
Abstract not available
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Ultrasound-dependent kinetics of bone mineralization Bone (IF 4.1) Pub Date : 2023-12-27 Julia R. Higdon, William L. Spooner, Jonghoon Kang
Bone Mineral Density (BMD) is an important parameter in the development of orthopedic fracture-healing methods. A recent article (Inoue, S., et al. Bone. 2023, 177, 116916) investigated the use of higher intensity ultrasound to promote murine bone formation by measuring BMD levels. In this work, we present the numerical values of BMD, which show sigmoid kinetics and hyperbolic asymptotic increase with
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Arterial stiffness and risk of new-onset fragility fracture in Chinese men and women: The Kailuan cohort study Bone (IF 4.1) Pub Date : 2023-12-21 Lu Guo, Nan Zhang, Yimeng Zhang, Lei Xing, Wenqi Xu, Wenjuan Li, Lisha Zhang, Xiaoli Hou, Shuohua Chen, Shouling Wu, Faming Tian
Background Previous studies have shown an association between increased arterial stiffness and reduced bone mineral density. However, the relationship between arterial stiffness and fragility fracture remains unclear. In this study, we explored the impact of arterial stiffness on the risk of new-onset fragility fracture. Methods The study included 53,107 participants in the Kailuan Study in whom brachial-ankle
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Impact of major osteoporotic fractures on the use of healthcare resources in Catalonia, Spain Bone (IF 4.1) Pub Date : 2023-12-23 Xavier Surís, Emili Vela, Marta Larrosa, Esteve Llargués, Maria J. Pueyo-Sánchez, José Manuel Cancio-Trujillo
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The risk of fractures after entering long-term care facilities Bone (IF 4.1) Pub Date : 2023-12-23 Tesfahun C. Eshetie, Gillian E. Caughey, Craig Whitehead, Maria Crotty, Megan Corlis, Renuka Visvanathan, Steve Wesselingh, Maria C. Inacio
Background Stratifying residents at increased risk for fractures in long-term care facilities (LTCFs) can potentially improve awareness and facilitate the delivery of targeted interventions to reduce risk. Although several fracture risk assessment tools exist, most are not suitable for individuals entering LTCF. Moreover, existing tools do not examine risk profiles of individuals at key periods in
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Bone ineral density, vitamin D and osseous metabolism indices in neurofibromatosis type 1: A systematic review and meta-analysis Bone (IF 4.1) Pub Date : 2023-12-21 Angelos Kaspiris, Elias Vasiliadis, Ilias D. Iliopoulos, Fotis Panagopoulos, Dimitra Melissaridou, Ioanna Lianou, Dimitrios Ntourantonis, Olga D. Savvidou, Evangelia Papadimitriou, Spiros G. Pneumaticos
Background Neurofibromatosis type 1 (NF1) is a genetic autosomal neurocutaneous syndrome correlated with skeletal dysplasia and defects in the osseous microarchitecture. The physiological mechanism for the development of NF1-related bone abnormal turnover is still unclear. Objectives A meta-analysis was performed to investigate the effects of NF1 on bone mineral density (BMD) and osseous metabolic
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The detection of Gper1 as an important gene promoting jawbone regeneration in the context of estrogen deficiency Bone (IF 4.1) Pub Date : 2023-12-21 Yuan Feng, Haicheng Wang, Shuyu Xu, Jie Huang, Qingguo Pei, Zuolin Wang
Numerous studies have demonstrated that estrogen deficiency inhibit the proliferation and differentiation of pre-osteoblasts in skeleton by affecting osteogenic signaling, lead to decreased bone mass and impaired regeneration. To explore the mechanisms maintaining bone regeneration under estrogen deficiency, we randomly selected 1102 clinical cases, in which female patients aged between 18 and 75 have