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Osteocytes and Paget’s Disease of Bone Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-03-08 Hirofumi Tenshin, Jesus Delgado-Calle, Jolene J. Windle, G. David Roodman, John M. Chirgwin, Noriyoshi Kurihara
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Extracellular Vesicles and Exosomes in the Control of the Musculoskeletal Health Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-03-01 Fabio Penna, Lorena Garcia-Castillo, Paola Costelli
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Neutrophils in Inflammatory Bone Diseases Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-02-29 Carmelo Carmona-Rivera, Mariana J. Kaplan, Liam J. O’Neil
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Fat as a Friend or Foe of the Bone Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-02-28
Abstract Purpose of Review The objective of this review is to summarize the literature on the prevalence and diagnosis of obesity and its metabolic profile, including bone metabolism, focusing on the main inflammatory and turnover bone mediators that better characterize metabolically healthy obesity phenotype, and to summarize the therapeutic interventions for obesity with their effects on bone health
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Interfacial Tissue Regeneration with Bone Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-02-15
Abstract Purpose of Review Interfacial tissue exists throughout the body at cartilage-to-bone (osteochondral interface) and tendon-to-bone (enthesis) interfaces. Healing of interfacial tissues is a current challenge in regenerative approaches because the interface plays a critical role in stabilizing and distributing the mechanical stress between soft tissues (e.g., cartilage and tendon) and bone.
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From the Mind to the Spine: The Intersecting World of Alzheimer’s and Osteoporosis Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-02-09 Tyler J. Margetts, Hannah S. Wang, Sonali J. Karnik, Lilian I. Plotkin, Alexandru Movila, Adrian L. Oblak, Jill C. Fehrenbacher, Melissa A. Kacena
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Regulation of FGF23 Production in Osteocytes Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-02-09
Abstract Purpose of Review FGF23 is a bone-derived hormone working to reduce serum phosphate level. This review focuses on recent findings regarding regulatory mechanisms of FGF23 expression in osteocytes, FGF23 levels, and activities. Recent Findings Circulatory FGF23 levels reflecting FGF23 biological activities can be regulated by both FGF23 expression and posttranslational modification of FGF23
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Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-31 Murad K. Nazzal, Ashlyn J. Morris, Reginald S. Parker, Fletcher A. White, Roman M. Natoli, Melissa A. Kacena, Jill C. Fehrenbacher
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Mind the Gap: Unraveling the Intricate Dance Between Alzheimer’s Disease and Related Dementias and Bone Health Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-29 Sonali J. Karnik, Tyler J. Margetts, Hannah S. Wang, Alexandru Movila, Adrian L. Oblak, Jill C. Fehrenbacher, Melissa A. Kacena, Lilian I. Plotkin
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Quantitative Skeletal Imaging and Image-Based Modeling in Pediatric Orthopaedics Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-20 Melissa R. Requist, Megan K. Mills, Kristen L. Carroll, Amy L. Lenz
Purpose of Review Musculoskeletal imaging serves a critical role in clinical care and orthopaedic research. Image-based modeling is also gaining traction as a useful tool in understanding skeletal morphology and mechanics. However, there are fewer studies on advanced imaging and modeling in pediatric populations. The purpose of this review is to provide an overview of recent literature on skeletal
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SARS-CoV-2 and its Multifaceted Impact on Bone Health: Mechanisms and Clinical Evidence Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-18 Alexander Harris, Amy Creecy, Olatundun D. Awosanya, Thomas McCune, Marie V. Ozanne, Angela J. Toepp, Melissa A. Kacena, Xian Qiao
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Cracking the Code: The Role of Peripheral Nervous System Signaling in Fracture Repair Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-18 Ashlyn J. Morris, Reginald S. Parker, Murad K. Nazzal, Roman M. Natoli, Jill C. Fehrenbacher, Melissa A. Kacena, Fletcher A. White
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Role of the Neurologic System in Fracture Healing: An Extensive Review Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-18 Reginald S. Parker, Murad K. Nazzal, Ashlyn J. Morris, Jill C. Fehrenbacher, Fletcher A. White, Melissa A. Kacena, Roman M. Natoli
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Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer’s Disease and Osteoporosis Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-18
Abstract Purpose of Review This comprehensive review discusses the complex relationship between Alzheimer’s disease (AD) and osteoporosis, two conditions that are prevalent in the aging population and result in adverse complications on quality of life. The purpose of this review is to succinctly elucidate the many commonalities between the two conditions, including shared pathways, inflammatory and
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The Use of Artificial Intelligence in Writing Scientific Review Articles Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-16 Melissa A. Kacena, Lilian I. Plotkin, Jill C. Fehrenbacher
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Use of AI Language Engine ChatGPT 4.0 to Write a Scientific Review Article Examining the Intersection of Alzheimer’s Disease and Bone Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-16 Tyler J. Margetts, Sonali J. Karnik, Hannah S. Wang, Lilian I. Plotkin, Adrian L. Oblak, Jill C. Fehrenbacher, Melissa A. Kacena, Alexandru Movila
Purpose of Review This Comment represents three review articles on the relationship between Alzheimer’s disease, osteoporosis, and fracture in an exploration of the benefits that AI can provide in scientific writing. The first drafts of the articles were written (1) entirely by humans; (2) entirely by ChatGPT 4.0 (AI-only or AIO); and (3) by humans and ChatGPT 4.0 whereby humans selected literature
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In Vivo Assessment of Bone Quality Without X-rays Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-16 Rachel K. Surowiec, Mark D. Does, Jeffry S. Nyman
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COVID-19 and Bone Loss: A Review of Risk Factors, Mechanisms, and Future Directions Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-15 Amy Creecy, Olatundun D. Awosanya, Alexander Harris, Xian Qiao, Marie Ozanne, Angela J. Toepp, Melissa A. Kacena, Thomas McCune
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The Utility of AI in Writing a Scientific Review Article on the Impacts of COVID-19 on Musculoskeletal Health Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-13 Olatundun D. Awosanya, Alexander Harris, Amy Creecy, Xian Qiao, Angela J. Toepp, Thomas McCune, Melissa A. Kacena, Marie V. Ozanne
Purpose of Review There were two primary purposes to our reviews. First, to provide an update to the scientific community about the impacts of COVID-19 on musculoskeletal health. Second, was to determine the value of using a large language model, ChatGPT 4.0, in the process of writing a scientific review article. To accomplish these objectives, we originally set out to write three review articles on
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Using AI to Write a Review Article Examining the Role of the Nervous System on Skeletal Homeostasis and Fracture Healing Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-13
Abstract Purpose of Review Three review articles have been written that discuss the roles of the central and peripheral nervous systems in fracture healing. While content among the articles is overlapping, there is a key difference between them: the use of artificial intelligence (AI). In one paper, the first draft was written solely by humans. In the second paper, the first draft was written solely
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The Role of Breast Cancer Cells in Bone Metastasis: Suitable Seeds for Nourishing Soil Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-11 Yiou Wang, Yue Hu, Mozhi Wang, Mengshen Wang, Yingying Xu
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The Role of Osteocytes in Pre-metastatic Niche Formation Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-10
Abstract Purpose of Review The formation of a pre-metastatic niche (PMN), in which primary cancer cells prime the distant site to be favorable to their engraftment and survival, may help explain the strong osteotropism observed in multiple cancers, such as breast and prostate. PMN formation, which includes extracellular matrix remodeling, increased angiogenesis and vascular permeability, enhanced bone
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Diabetes and the Microvasculature of the Bone and Marrow Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-10 Teresa Le, Amanda Salas Sanchez, Danyah Nashawi, Sunidhi Kulkarni, Rhonda D. Prisby
Purpose of Review The purpose of this review is to highlight the evidence of microvascular dysfunction in bone and marrow and its relation to poor skeletal outcomes in diabetes mellitus. Recent Findings Diabetes mellitus is characterized by chronic hyperglycemia, which may lead to microangiopathy and macroangiopathy. Micro- and macroangiopathy have been diagnosed in Type 1 and Type 2 diabetes, coinciding
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The Bone-Vascular Axis in Chronic Kidney Disease: From Pathophysiology to Treatment Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-10 Clément Vachey, Alexandre Candellier, Soline Toutain, Fabrice Mac-Way
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Oncostatin M: Dual Regulator of the Skeletal and Hematopoietic Systems Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2024-01-10 Natalie A. Sims, Jean-Pierre Lévesque
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Anesthetic Methods for Hip Fracture Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-12-22 Lisa Reider, David Furgiuele, Philip Wan, Benjamin Schaffler, Sanjit Konda
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Efficacy of Osteoporosis Medications in Patients with Type 2 Diabetes Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-12-14 Tatiane Vilaca, Richard Eastell
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Racial/Ethnic Differences in Bone Mineral Density for Osteoporosis Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-11-29 Qing Wu, Jingyuan Dai
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Practical Compass of Single-Cell RNA-Seq Analysis Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-11-29 Hiroyuki Okada, Ung-il Chung, Hironori Hojo
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Loss of Muscle Mass and Strength After Hip Fracture: an Intervention Target for Nutrition Supplementation Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-11-29 Lisa Reider, Erin C. Owen, Hans C. Dreyer, Lori S. Fitton, Michael C. Willey
Purposeof Review To summarize what is known about the deleterious effect of hip fracture on muscle mass and strength as well as the scientific evidence for post-surgical nutrition supplementation to maintain muscle and improve function. Recent Findings This review provides a discussion of the relationship between muscle mass, strength, and physical function following hip fracture, briefly describes
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Biomimetic Inspired Hydrogels for Regenerative Vertebral Body Stenting Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-11-25 Kulwinder Kaur, Ruby Sannoufi, Joseph S. Butler, Ciara M. Murphy
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Weight-bearing Guidelines for Common Geriatric Upper and Lower Extremity Fractures Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-11-16 Willie Dong, Leonard S. J. Lisitano, Lucas S. Marchand, Lisa M. Reider, Justin M. Haller
Purpose of Review The purpose of this review paper is to summarize current weight-bearing guidelines for common geriatric fractures, around weight-bearing joints, of the upper and lower extremities. Recent Findings There is an increasing amount of literature investigating the safety and efficacy of early weight-bearing in geriatric fractures, particularly of the lower extremity. Many recent studies
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Zebrafish as a Model for Osteoporosis: Functional Validations of Genome-Wide Association Studies Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-11-16 Inbar Ben-Zvi, David Karasik, Cheryl L. Ackert-Bicknell
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Micropetrosis: Osteocyte Lacunar Mineralization in Aging and Disease Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-11-02 Petar Milovanovic, Björn Busse
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Bone Material Properties in Bone Diseases Affecting Children Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-10-28 Adalbert Raimann, Barbara M. Misof, Peter Fratzl, Nadja Fratzl-Zelman
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Characterizing Bone Phenotypes Related to Skeletal Fragility Using Advanced Medical Imaging Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-10-26 Danielle E. Whittier, Melissa S. A. M. Bevers, Piet P. M. M. Geusens, Joop P. van den Bergh, Leigh Gabel
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Genetic and Gene Expression Resources for Osteoporosis and Bone Biology Research Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-10-13 Serra Kaya, Tamara Alliston, Daniel S. Evans
Purpose of Review The integration of data from multiple genomic assays from humans and non-human model organisms is an effective approach to identify genes involved in skeletal fragility and fracture risk due to osteoporosis and other conditions. This review summarizes genome-wide genetic variation and gene expression data resources relevant to the discovery of genes contributing to skeletal fragility
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The Origin and Fate of Chondrocytes: Cell Plasticity in Physiological Setting Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-10-14 Andrei S. Chagin, Tsz Long Chu
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Novel Insights into Osteoclast Energy Metabolism Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-10-10 Maria G. Ledesma-Colunga, Vanessa Passin, Franziska Lademann, Lorenz C. Hofbauer, Martina Rauner
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The Differential Effect of Metformin on Osteocytes, Osteoblasts, and Osteoclasts Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-10-05 Teun J. de Vries, Antonella S. Kleemann, Jianfeng Jin, Ton Schoenmaker
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Osteocyte Mechanotransduction in Orthodontic Tooth Movement Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-10-04 Hadi Seddiqi, Jenneke Klein-Nulend, Jianfeng Jin
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Inflammatory Processes Affecting Bone Health and Repair Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-09-28 Haydee M. Torres, Katherine M. Arnold, Manuela Oviedo, Jennifer J. Westendorf, Samantha R. Weaver
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Early Life Management of Osteogenesis Imperfecta Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-09-26 Paul Arundel, Stephanie A. Borg
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The Utility of Preclinical Models in Understanding the Bone Health of Transgender Individuals Undergoing Gender-Affirming Hormone Therapy Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-09-14 Varun S. Venkatesh, Tian Nie, Jeffrey D. Zajac, Mathis Grossmann, Rachel A. Davey
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Influences of Aged Bone Marrow Macrophages on Skeletal Health and Senescence Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-09-09 Moritz Pappert, Sundeep Khosla, Madison Doolittle
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Osteocytes and Primary Cilia Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-09-08 Stefaan W. Verbruggen, Anuphan Sittichokechaiwut, Gwendolen C. Reilly
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From Inflammation to Resolution: Specialized Pro-resolving Mediators in Posttraumatic Osteoarthritis Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-08-24 Chilan B. G. Leite, Gergo Merkely, Julia F. Charles, Christian Lattermann
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Racial and Ethnic Differences in Studies of the Gut Microbiome and Osteoporosis Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-08-19 Lisa C. Merrill, Kelsey M. Mangano
Purpose of Review The purpose of this review is to summarize the scientific evidence published in the past 5 years examining the epidemiology of bone health as it relates to the gut microbiome, across race and ethnicity groups. Recent Findings The link between the gut microbiome and bone health is well established and is supported by numerous biological mechanisms. However, human study research in
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Role of the Peripheral Nervous System in Skeletal Development and Regeneration: Controversies and Clinical Implications Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-08-14 Mohamed G. Hassan, Allison L. Horenberg, Ariella Coler-Reilly, Warren L. Grayson, Erica L. Scheller
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Osteoporosis and Fracture Risk among Older US Asian Adults Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-08-05 Joan C. Lo, Wei Yang, Jennifer J. Park-Sigal, Susan M. Ott
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Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-08-05 Sarah E. Catheline, Ethan Kaiser, Roman A. Eliseev
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Fracture Risk in Patients with Hypoparathyroidism Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-08-05 Lars Rejnmark, Line Underbjerg
Purpose of Review To summarize the recently published scientific evidence on fracture risk in hypoparathyroidism. Recent Findings Hypoparathyroidism is characterized by a low bone turnover and a high bone mineral density. Data on fracture risk are sparse and due to the rarity of the disease, available studies have only been able to include relatively few patients. Risk of non-vertebral fractures does
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Genetics of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of the Spinal Ligaments Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-08-02 Hajime Kato, Demetrios T. Braddock, Nobuaki Ito
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Sclerostin and Cardiovascular Disease Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-07-25 Jonathan H. Tobias
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Defects in Bone and Bone Marrow in Inherited Anemias: the Chicken or the Egg Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-07-12 Rachel Willimann, Christina Chougar, Lawrence C. Wolfe, Lionel Blanc, Jeffrey M. Lipton
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Runt-related Transcription Factors and Gene Regulatory Mechanisms in Skeletal Development and Diseases Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-07-12 Hironori Hojo, Shinsuke Ohba
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Recommendations for High-resolution Peripheral Quantitative Computed Tomography Assessment of Bone Density, Microarchitecture, and Strength in Pediatric Populations Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-07-10 L. Gabel, K. Kent, S. Hosseinitabatabaei, A. J. Burghardt, M. B. Leonard, F. Rauch, B. M. Willie
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Cranial Neural Crest Cells Contribution to Craniofacial Bone Development and Regeneration Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-07-08 Piera Smeriglio, Antoine Zalc
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Bone Trans-omics: Integrating Omics to Unveil Mechanistic Molecular Networks Regulating Bone Biology and Disease Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-07-06 Benjamin H. Mullin, Amy B. P. Ribet, Nathan J. Pavlos
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The Multifaceted Effects of Osteocytic TGFβ Signaling on the Skeletal and Extraskeletal Functions of Bone Curr. Osteoporos. Rep. (IF 4.3) Pub Date : 2023-07-03 M. Carroll, T. Alliston, N. Dole