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Halicin remains active against Staphylococcus aureus in biofilms grown on orthopaedically relevant substrates. Bone Joint Res. (IF 4.6) Pub Date : 2024-03-04 Shota Higashihira, Stefanie J Simpson, Akira Morita, Joash R Suryavanshi, Christopher J Arnold, Roman M Natoli, Edward M Greenfield
Biofilm infections are among the most challenging complications in orthopaedics, as bacteria within the biofilms are protected from the host immune system and many antibiotics. Halicin exhibits broad-spectrum activity against many planktonic bacteria, and previous studies have demonstrated that halicin is also effective against Staphylococcus aureus biofilms grown on polystyrene or polypropylene substrates
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Effects of high antibiotic concentrations applied to continuous local antibiotic perfusion on human bone tissue-derived cells. Bone Joint Res. (IF 4.6) Pub Date : 2024-03-01 Yuya Yamamoto, Tomoaki Fukui, Kenichi Sawauchi, Ryo Yoshikawa, Kyohei Takase, Yohei Kumabe, Akihiro Maruo, Takahiro Niikura, Ryosuke Kuroda, Keisuke Oe
Continuous local antibiotic perfusion (CLAP) has recently attracted attention as a new drug delivery system for orthopaedic infections. CLAP is a direct continuous infusion of high-concentration gentamicin (1,200 μg/ml) into the bone marrow. As it is a new system, its influence on the bone marrow is unknown. This study aimed to examine the effects of high-concentration antibiotics on human bone tissue-derived
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RANKL, OPG, and RUNX2 expression and epigenetic modifications in giant cell tumour of bone in 32 patients. Bone Joint Res. (IF 4.6) Pub Date : 2024-02-19 Raja Amri, Ameni Chelly, Mariem Ayedi, Mohammed A Rebaii, Sami Aifa, Sabeur Masmoudi, Hassib Keskes
The present study investigated receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG), and Runt-related transcription factor 2 (RUNX2) gene expressions in giant cell tumour of bone (GCTB) patients in relationship with tumour recurrence. We also aimed to investigate the influence of CpG methylation on the transcriptional levels of RANKL and OPG.
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Transcriptomic analyses and machine-learning methods reveal dysregulated key genes and potential pathogenesis in human osteoarthritic cartilage. Bone Joint Res. (IF 4.6) Pub Date : 2024-02-05 Di Zhao, Ling-Feng Zeng, Gui-Hong Liang, Ming-Hui Luo, Jian-Ke Pan, Yao-Xing Dou, Fang-Zheng Lin, He-Tao Huang, Wei-Yi Yang, Jun Liu
This study aimed to explore the biological and clinical importance of dysregulated key genes in osteoarthritis (OA) patients at the cartilage level to find potential biomarkers and targets for diagnosing and treating OA.
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Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway. Bone Joint Res. (IF 4.6) Pub Date : 2024-02-01 Chen Yao, Jie Sun, Wanxin Luo, Hao Chen, Tianhao Chen, Cao Chen, Bo Zhang, Yafeng Zhang
To investigate the effects of senescent osteocytes on bone homeostasis in the progress of age-related osteoporosis and explore the underlying mechanism.
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Sex differences of NF-κB-targeted therapy for mitigating osteoporosis associated with chronic inflammation of bone. Bone Joint Res. (IF 4.6) Pub Date : 2024-01-10 Masakazu Toya, Junichi Kushioka, Huaishuang Shen, Takeshi Utsunomiya, Hirohito Hirata, Masanori Tsubosaka, Qi Gao, Simon K-H Chow, Ning Zhang, Stuart B Goodman
Transcription factor nuclear factor kappa B (NF-κB) plays a major role in the pathogenesis of chronic inflammatory diseases in all organ systems. Despite its importance, NF-κB targeted drug therapy to mitigate chronic inflammation has had limited success in preclinical studies. We hypothesized that sex differences affect the response to NF-κB treatment during chronic inflammation in bone. This study
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The PJI-TNM classification for periprosthetic joint infections. Bone Joint Res. (IF 4.6) Pub Date : 2024-01-05 Susanne Baertl, Markus Rupp, Maximilian Kerschbaum, Mario Morgenstern, Florian Baumann, Christian Pfeifer, Michael Worlicek, Daniel Popp, Derek F Amanatullah, Volker Alt
This study aimed to evaluate the clinical application of the PJI-TNM classification for periprosthetic joint infection (PJI) by determining intraobserver and interobserver reliability. To facilitate its use in clinical practice, an educational app was subsequently developed and evaluated.
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Biomimetic vascularized adipose-derived mesenchymal stem cells bone-periosteum graft enhances angiogenesis and osteogenesis in a male rabbit spine fusion model. Bone Joint Res. (IF 4.6) Pub Date : 2023-12-06 Tsai-Sheng Fu, Wei-Chuan Chen, Ying-Chih Wang, Chia-Wei Chang, Tung-Yi Lin, Chak-Bor Wong
Several artificial bone grafts have been developed but fail to achieve anticipated osteogenesis due to their insufficient neovascularization capacity and periosteum support. This study aimed to develop a vascularized bone-periosteum construct (VBPC) to provide better angiogenesis and osteogenesis for bone regeneration.
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Classification of distinct osteoarthritis subtypes with different knee joint tissues by gene expression profiles. Bone Joint Res. (IF 4.6) Pub Date : 2023-12-01 Yuan Xue, Liang Zhou, Jiaqian Wang
Knee osteoarthritis (OA) involves a variety of tissues in the joint. Gene expression profiles in different tissues are of great importance in order to understand OA.
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Interleukin-19 promotes bone resorption by suppressing osteoprotegerin expression in BMSCs in a lipopolysaccharide-induced bone loss mouse model. Bone Joint Res. (IF 4.6) Pub Date : 2023-11-03 Zhicheng Dai,Yanan Chen,Enjun He,Hongjie Wang,Weihong Guo,Zhenkai Wu,Kai Huang,Qinghua Zhao
Aims Osteoporosis is characterized by decreased trabecular bone volume, and microarchitectural deterioration in the medullary cavity. Interleukin-19 (IL-19), a member of the IL-10 family, is an anti-inflammatory cytokine produced primarily by macrophages. The aim of our study was to investigate the effect of IL-19 on osteoporosis. Methods Blood and femoral bone marrow suspension IL-19 levels were first
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Melatonin induces RAW264.7 cell apoptosis via the BMAL1/ROS/MAPK-p38 pathway to improve postmenopausal osteoporosis. Bone Joint Res. (IF 4.6) Pub Date : 2023-11-01 Xiaochuan Wang,Wen Jiang,Kexin Pan,Lin Tao,Yue Zhu
Aims Currently, the effect of drug treatment for osteoporosis is relatively poor, and the side effects are numerous and serious. Melatonin is a potential drug to improve bone mass in postmenopausal women. Unfortunately, the mechanism by which melatonin improves bone metabolism remains unclear. The aim of this study was to further investigate the potential mechanism of melatonin in the treatment of
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Comparative effect of platelet- and mesenchymal stromal cell-derived extracellular vesicles on human cartilage explants using an ex vivo inflammatory osteoarthritis model. Bone Joint Res. (IF 4.6) Pub Date : 2023-10-19 Maria A Forteza-Genestra, Miquel Antich-Rosselló, Guillem Ramis-Munar, Javier Calvo, Antoni Gayà, Marta Monjo, Joana M Ramis
Extracellular vesicles (EVs) are nanoparticles secreted by all cells, enriched in proteins, lipids, and nucleic acids related to cell-to-cell communication and vital components of cell-based therapies. Mesenchymal stromal cell (MSC)-derived EVs have been studied as an alternative for osteoarthritis (OA) treatment. However, their clinical translation is hindered by industrial and regulatory challenges
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Unbiased gene expression analysis of the delayed fracture healing observed in Zucker diabetic fatty rats. Bone Joint Res. (IF 4.6) Pub Date : 2023-10-17 Jonghoo Sung, Kate R Barratt, Stephen M Pederson, Chantal Chenu, Ines Reichert, Gerald J Atkins, Paul H Anderson, Peter J Smitham
Impaired fracture repair in patients with type 2 diabetes mellitus (T2DM) is not fully understood. In this study, we aimed to characterize the local changes in gene expression (GE) associated with diabetic fracture. We used an unbiased approach to compare GE in the fracture callus of Zucker diabetic fatty (ZDF) rats relative to wild-type (WT) littermates at three weeks following femoral osteotomy.
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Disease-modifying agents in osteoarthritis: where are we now and what does the future hold? Bone Joint Res. (IF 4.6) Pub Date : 2023-10-16 Navnit S Makaram,A H R W Simpson
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Diathermy and bone sawing are high aerosol yield procedures. Bone Joint Res. (IF 4.6) Pub Date : 2023-10-10 Victoria Hamilton, Sadiyah Sheikh, Alicja Szczepanska, Nick Maskell, Fergus Hamilton, Jonathan P Reid, Bryan R Bzdek, James R D Murray
Orthopaedic surgery uses many varied instruments with high-speed, high-impact, thermal energy and sometimes heavy instruments, all of which potentially result in aerosolization of contaminated blood, tissue, and bone, raising concerns for clinicians' health. This study quantifies the aerosol exposure by measuring the number and size distribution of the particles reaching the lead surgeon during key
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Increased local bone turnover in patients with chronic periprosthetic joint infection. Bone Joint Res. (IF 4.6) Pub Date : 2023-10-10 Nico Hinz, Sebastian Butscheidt, Nico M Jandl, Holger Rohde, Johannes Keller, Frank T Beil, Jan Hubert, Tim Rolvien
The management of periprosthetic joint infection (PJI) remains a major challenge in orthopaedic surgery. In this study, we aimed to characterize the local bone microstructure and metabolism in a clinical cohort of patients with chronic PJI.
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Overcoming floor and ceiling effects in knee arthroplasty outcome measurement. Bone Joint Res. (IF 4.6) Pub Date : 2023-10-04 Conrad J Harrison,Constantin Y Plessen,Gregor Liegl,Jeremy N Rodrigues,Shiraz A Sabah,David J Beard,Felix Fischer
Aims To map the Oxford Knee Score (OKS) and High Activity Arthroplasty Score (HAAS) items to a common scale, and to investigate the psychometric properties of this new scale for the measurement of knee health. Methods Patient-reported outcome measure (PROM) data measuring knee health were obtained from the NHS PROMs dataset and Total or Partial Knee Arthroplasty Trial (TOPKAT). Assumptions for common
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Regeneration of injured articular cartilage using the recombinant human amelogenin protein. Bone Joint Res. (IF 4.6) Pub Date : 2023-10-03 Omer Helwa-Shalom, Faris Saba, Elad Spitzer, Salem Hanhan, Koby Goren, Shany I Markowitz, Dekel Shilo, Nissim Khaimov, Yechiel N Gellman, Dan Deutsch, Anat Blumenfeld, Hani Nevo, Amir Haze
Cartilage injuries rarely heal spontaneously and often require surgical intervention, leading to the formation of biomechanically inferior fibrous tissue. This study aimed to evaluate the possible effect of amelogenin on the healing process of a large osteochondral injury (OCI) in a rat model.
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Decision-making in surgical study designs: a proposed decision algorithm to aid in the selection of an appropriate research study design for a given surgical intervention: the PERFECT tool. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-21 A H R W Simpson,Navnit S Makaram,Ewen Harrison,John Norrie
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Appraising causal risk and protective factors for rheumatoid arthritis. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-21 Peng Gu,Bin Pu,Teng Liu,Dan Yue,Qiao Xin,Hai-Shan Li,Bai-Lin Yang,Dao-Ze Ke,Xiao-Hui Zheng,Zhan-Peng Zeng,Zhi-Qiang Zhang
Aims Mendelian randomization (MR) is considered to overcome the bias of observational studies, but there is no current meta-analysis of MR studies on rheumatoid arthritis (RA). The purpose of this study was to summarize the relationship between potential pathogenic factors and RA risk based on existing MR studies. Methods PubMed, Web of Science, and Embase were searched for MR studies on influencing
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Defining the optimal position of the lipped liner in combination with cup orientation and stem version. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-20 Alessandro Navacchia, Joseph Pagkalos, Edward T Davis
The aim of this study was to identify the optimal lip position for total hip arthroplasties (THAs) using a lipped liner. There is a lack of consensus on the optimal position, with substantial variability in surgeon practice.
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Global and local fat effects on bone mass and quality in obesity. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-20 Xin Dai, Beizhong Liu, Qingtao Hou, Qijie Dai, Di Wang, Bo Xie, Yue Sun, Bin Wang
The aim of this study was to investigate the global and local impact of fat on bone in obesity by using the diet-induced obese (DIO) mouse model.
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Development and validation of an open-source tool for opportunistic screening of osteoporosis from hip CT images. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-20 Keisuke Uemura, Yoshito Otake, Kazuma Takashima, Hidetoshi Hamada, Takashi Imagama, Masaki Takao, Takashi Sakai, Yoshinobu Sato, Seiji Okada, Nobuhiko Sugano
This study aimed to develop and validate a fully automated system that quantifies proximal femoral bone mineral density (BMD) from CT images.
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Diagnosis of periprosthetic joint infections in patients who have rheumatoid arthritis. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-14 Yulai Wang, Guoqing Li, Baochao Ji, Boyong Xu, Xiaogang Zhang, Asihaerjiang Maimaitiyiming, Li Cao
To investigate the optimal thresholds and diagnostic efficacy of commonly used serological and synovial fluid detection indexes for diagnosing periprosthetic joint infection (PJI) in patients who have rheumatoid arthritis (RA).
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Treatment of infected bone defects with the induced membrane technique. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-12 Jie Shen, Zhiyuan Wei, Shulin Wang, Xiaohua Wang, Wei Lin, Lei Liu, Guanglin Wang
This study aimed to evaluate the effectiveness of the induced membrane technique for treating infected bone defects, and to explore the factors that might affect patient outcomes.
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The role of cells and signal pathways in subchondral bone in osteoarthritis. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-08 Pan Luo, Qi-Ling Yuan, Mingyi Yang, Xianjie Wan, Peng Xu
Osteoarthritis (OA) is mainly caused by ageing, strain, trauma, and congenital joint abnormalities, resulting in articular cartilage degeneration. During the pathogenesis of OA, the changes in subchondral bone (SB) are not only secondary manifestations of OA, but also an active part of the disease, and are closely associated with the severity of OA. In different stages of OA, there were microstructural
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Identification and experimental validation of key extracellular proteins as potential targets in intervertebral disc degeneration. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-04 Guang-Zhi Zhang,Lei Li,Zhang-Bin Luo,Cang-Yu Zhang,Yong-Gang Wang,Xue-Wen Kang
Aims This study aimed, through bioinformatics analysis and in vitro experiment validation, to identify the key extracellular proteins of intervertebral disc degeneration (IDD). Methods The gene expression profile of GSE23130 was downloaded from the Gene Expression Omnibus (GEO) database. Extracellular protein-differentially expressed genes (EP-DEGs) were screened by protein annotation databases, and
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Predicting whether patients will achieve minimal clinically important differences following hip or knee arthroplasty. Bone Joint Res. (IF 4.6) Pub Date : 2023-09-01 Benedikt Langenberger, Daniel Schrednitzki, Andreas M Halder, Reinhard Busse, Christoph M Pross
A substantial fraction of patients undergoing knee arthroplasty (KA) or hip arthroplasty (HA) do not achieve an improvement as high as the minimal clinically important difference (MCID), i.e. do not achieve a meaningful improvement. Using three patient-reported outcome measures (PROMs), our aim was: 1) to assess machine learning (ML), the simple pre-surgery PROM score, and logistic-regression (LR)-derived
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Thickness of simple calcaneal tuberosity avulsion fractures influences the optimal fixation method employed. Bone Joint Res. (IF 4.6) Pub Date : 2023-08-23 Chunliang Wang, Shih-Jung Liu, Chung-Hsun Chang
This study aimed to establish the optimal fixation methods for calcaneal tuberosity avulsion fractures with different fragment thicknesses in a porcine model.
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Effect of surface matching mismatch of focal knee articular prosthetic on tibiofemoral contact stress using finite element analysis. Bone Joint Res. (IF 4.6) Pub Date : 2023-08-16 Jin-Ah Lee,Yong-Gon Koh,Paul S Kim,Joon-Hee Park,Kyoung-Tak Kang
Aims Focal knee arthroplasty is an attractive alternative to knee arthroplasty for young patients because it allows preservation of a large amount of bone for potential revisions. However, the mechanical behaviour of cartilage has not yet been investigated because it is challenging to evaluate in vivo contact areas, pressure, and deformations from metal implants. Therefore, this study aimed to determine
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Adiponectin inhibits fibrosis of the palmar aponeurosis in Dupuytren's contracture in male patients. Bone Joint Res. (IF 4.6) Pub Date : 2023-08-04 Yoshiaki Yamanaka,Takafumi Tajima,Yoshitaka Tsujimura,Toichiro Naito,Yosuke Mano,Manabu Tsukamoto,Yukichi Zenke,Akinori Sakai
Aims Dupuytren's contracture is characterized by increased fibrosis of the palmar aponeurosis, with eventual replacement of the surrounding fatty tissue with palmar fascial fibromatosis. We hypothesized that adipocytokines produced by adipose tissue in contact with the palmar aponeurosis might promote fibrosis of the palmar aponeurosis. Methods We compared the expression of the adipocytokines adiponectin
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Astragalus polysaccharide promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells by facilitating ANKFY1 expression through miR-760 inhibition. Bone Joint Res. (IF 4.6) Pub Date : 2023-08-03 Xianfeng Hu,Liu Yang,Yanhua Du,Xiangping Meng,Yuanyuan Shi,Juan Zeng
Aims Astragalus polysaccharide (APS) participates in various processes, such as the enhancement of immunity and inhibition of tumours. APS can affect osteoporosis (OP) by regulating the osteogenic differentiation of human bone mesenchymal stem cells (hBMSCs). This study was designed to elucidate the mechanism of APS in hBMSC proliferation and osteoblast differentiation. Methods Reverse transcriptase
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Incidence and risk factors of recurrence in limb osteomyelitis patients after antibiotic-loaded cement spacer for definitive bone defect treatment. Bone Joint Res. (IF 4.6) Pub Date : 2023-08-02 Hongri Wu,Dong Sun,Shulin Wang,Chao Jia,Jie Shen,Xiaohua Wang,Chunli Hou,Zhao Xie,Fei Luo
Aims This study was designed to characterize the recurrence incidence and risk factors of antibiotic-loaded cement spacer (ALCS) for definitive bone defect treatment in limb osteomyelitis. Methods We included adult patients with limb osteomyelitis who received debridement and ALCS insertion into the bone defect as definitive management between 2013 and 2020 in our clinical centre. The follow-up time
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High-intensity interval training improves fatty infiltration in the rotator cuff through the β3 adrenergic receptor in mice. Bone Joint Res. (IF 4.6) Pub Date : 2023-08-01 Hecheng Zhou, Chuanshun Chen, Hai Hu, Binbin Jiang, Yuesong Yin, Kexiang Zhang, Minren Shen, Song Wu, Zili Wang
Rotator cuff muscle atrophy and fatty infiltration affect the clinical outcomes of rotator cuff tear patients. However, there is no effective treatment for fatty infiltration at this time. High-intensity interval training (HIIT) helps to activate beige adipose tissue. The goal of this study was to test the role of HIIT in improving muscle quality in a rotator cuff tear model via the β3 adrenergic receptor
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Upregulated ribosome pathway plays a key role in HDAC4, improving the survival rate and biofunction of chondrocytes. Bone Joint Res. (IF 4.6) Pub Date : 2023-07-07 Li Guo, Hua Guo, Yuanyu Zhang, Zhi Chen, Jian Sun, Gaige Wu, Yunfei Wang, Yang Zhang, Xiaochun Wei, Pengcui Li
To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis.
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The association between selenium and bone health: a meta-analysis. Bone Joint Res. (IF 4.6) Pub Date : 2023-07-06 Haibin Xie, Ning Wang, Hongyi He, Zidan Yang, Jing Wu, Tuo Yang, Yilun Wang
Previous studies have suggested that selenium as a trace element is involved in bone health, but findings related to the specific effect of selenium on bone health remain inconclusive. Thus, we performed a meta-analysis by including all the relevant studies to elucidate the association between selenium status (dietary intake or serum selenium) and bone health indicators (bone mineral density (BMD)
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A comparison of clinical and radiological outcomes between two different biodegradable local antibiotic carriers used in the single-stage surgical management of long bone osteomyelitis. Bone Joint Res. (IF 4.6) Pub Date : 2023-07-04 Jamie Ferguson, Jonathan Bourget-Murray, David Stubbs, Martin McNally, Andrew J Hotchen
Dead-space management, following dead bone resection, is an important element of successful chronic osteomyelitis treatment. This study compared two different biodegradable antibiotic carriers used for dead-space management, and reviewed clinical and radiological outcomes. All cases underwent single-stage surgery and had a minimum one-year follow-up.
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Multiple roles of ALK3 in osteoarthritis. Bone Joint Res. (IF 4.6) Pub Date : 2023-07-03 Xianchun Ruan, Jinning Gu, Mingyang Chen, Fulin Zhao, Munire Aili, Demao Zhang
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage degradation, synovial membrane inflammation, osteophyte formation, and subchondral bone sclerosis. Pathological changes in cartilage and subchondral bone are the main processes in OA. In recent decades, many studies have demonstrated that activin-like kinase 3 (ALK3), a bone morphogenetic protein receptor
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Transcriptome-wide association study reveals candidate causal genes for lumbar spinal stenosis. Bone Joint Res. (IF 4.6) Pub Date : 2023-06-26 Jiawen Xu,Haibo Si,Yi Zeng,Yuangang Wu,Shaoyun Zhang,Bin Shen
Aims Lumbar spinal stenosis (LSS) is a common skeletal system disease that has been partly attributed to genetic variation. However, the correlation between genetic variation and pathological changes in LSS is insufficient, and it is difficult to provide a reference for the early diagnosis and treatment of the disease. Methods We conducted a transcriptome-wide association study (TWAS) of spinal canal
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LncRNA PCBP1-AS1 induces osteoporosis by sponging miR-126-5p/PAK2 axis. Bone Joint Res. (IF 4.6) Pub Date : 2023-06-12 Zhihui Li
Long non-coding RNAs (lncRNAs) act as crucial regulators in osteoporosis (OP). Nonetheless, the effects and potential molecular mechanism of lncRNA PCBP1 Antisense RNA 1 (PCBP1-AS1) on OP remain largely unclear. The aim of this study was to explore the role of lncRNA PCBP1-AS1 in the pathogenesis of OP.
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Are we doing the right surgical trials? Bone Joint Res. (IF 4.6) Pub Date : 2023-06-08 Navnit S Makaram,Sallie E Lamb,A Hamish R W Simpson
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Inflammatory bowel disease is associated with an increased risk of adverse events in patients undergoing joint arthroplasty. Bone Joint Res. (IF 4.6) Pub Date : 2023-06-01 Dongdong Xu,Cheng Ding,Tao Cheng,Chao Yang,Xianlong Zhang
Aims The present study aimed to investigate whether patients with inflammatory bowel disease (IBD) undergoing joint arthroplasty have a higher incidence of adverse outcomes than those without IBD. Methods A comprehensive literature search was conducted to identify eligible studies reporting postoperative outcomes in IBD patients undergoing joint arthroplasty. The primary outcomes included postoperative
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The core outcomes for open lower limb fracture study. Bone Joint Res. (IF 4.6) Pub Date : 2023-06-01 Alexander L Aquilina,Harry Claireaux,Christian O Aquilina,Elizabeth Tutton,Ray Fitzpatrick,Matthew L Costa,Xavier L Griffin
Aims A core outcome set for adult, open lower limb fracture has been established consisting of 'Walking, gait and mobility', 'Being able to return to life roles', 'Pain or discomfort', and 'Quality of life'. This study aims to identify which outcome measurement instruments (OMIs) should be recommended to measure each core outcome. Methods A systematic review and quality assessment were conducted to
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Effect of treadmill training on fibrocartilage complex repair in tendon-bone insertion healing in the postinflammatory stage. Bone Joint Res. (IF 4.6) Pub Date : 2023-05-23 Jindong Tan, Xiao Liu, Mei Zhou, Feng Wang, Lin Ma, Hong Tang, Gang He, Xia Kang, Xuting Bian, Kanglai Tang
Mechanical stimulation is a key factor in the development and healing of tendon-bone insertion. Treadmill training is an important rehabilitation treatment. This study aims to investigate the benefits of treadmill training initiated on postoperative day 7 for tendon-bone insertion healing.
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Infection after intracapsular femoral neck fracture - does antibiotic-loaded bone cement reduce infection risk after hemiarthroplasty and total hip arthroplasty? Bone Joint Res. (IF 4.6) Pub Date : 2023-05-16 Dominik Szymski,Nike Walter,Paula Krull,Oliver Melsheimer,Alexander Grimberg,Volker Alt,Arnd Steinbrueck,Markus Rupp
Aims The aim of this investigation was to compare risk of infection in both cemented and uncemented hemiarthroplasty (HA) as well as in total hip arthroplasty (THA) following femoral neck fracture. Methods Data collection was performed using the German Arthroplasty Registry (EPRD). In HA and THA following femoral neck fracture, fixation method was divided into cemented and uncemented prostheses and
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Mortality and re-revision following single-stage and two-stage revision surgery for the management of infected primary hip arthroplasty in England and Wales. Bone Joint Res. (IF 4.6) Pub Date : 2023-05-09 Erik Lenguerrand, Michael R Whitehouse, Andrew D Beswick, Setor K Kunutsor, Jason C J Webb, Sanchit Mehendale, Martyn Porter, Ashley W Blom
We compared the risks of re-revision and mortality between two-stage and single-stage revision surgeries among patients with infected primary hip arthroplasty. Patients with a periprosthetic joint infection (PJI) of their primary arthroplasty revised with single-stage or two-stage procedure in England and Wales between 2003 and 2014 were identified from the National Joint Registry. We used Poisson
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Reliability and validity of pose estimation algorithm for measurement of knee range of motion after total knee arthroplasty. Bone Joint Res. (IF 4.6) Pub Date : 2023-05-08 Yoshitomo Saiki,Tamon Kabata,Tomohiro Ojima,Yoshitomo Kajino,Naoyuki Kubo,Hiroyuki Tsuchiya
We aimed to assess the reliability and validity of OpenPose, a posture estimation algorithm, for measurement of knee range of motion after total knee arthroplasty (TKA), in comparison to radiography and goniometry. In this prospective observational study, we analyzed 35 primary TKAs (24 patients) for knee osteoarthritis. We measured the knee angles in flexion and extension using OpenPose, radiography
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Osteosarcoma cells/cell lines are not appropriate for studies on bone regeneration in vitro. Bone Joint Res. (IF 4.6) Pub Date : 2023-05-05 Chunfeng Xu,Yuelian Liu
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Infographic: Total hip arthroplasty in early osteoarthritis. Bone Joint Res. (IF 4.6) Pub Date : 2023-05-05 Martin Sharrock,Tim Board
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The complexity of decision-making for total hip arthroplasty in early osteoarthritis. Bone Joint Res. (IF 4.6) Pub Date : 2023-05-01 Martin Sharrock,Tim Board
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Development of a core outcome set for open lower limb fracture. Bone Joint Res. (IF 4.6) Pub Date : 2023-04-20 Alexander L Aquilina, Henry Claireaux, Christian O Aquilina, Elizabeth Tutton, Ray Fitzpatrick, Matthew L Costa, Xavier L Griffin
Open lower limb fracture is life-changing, resulting in substantial morbidity and resource demand, while inconsistent outcome-reporting hampers systematic review and meta-analysis. A core outcome set establishes consensus among key stakeholders for the recommendation of a minimum set of outcomes. This study aims to define a core outcome set for adult open lower limb fracture. Candidate outcomes were
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Dihydrocaffeic acid improves IL-1β-induced inflammation and cartilage degradation via inhibiting NF-κB and MAPK signalling pathways. Bone Joint Res. (IF 4.6) Pub Date : 2023-04-06 Rui Lu, Ying-Guang Wang, Yunkun Qu, Shan-Xi Wang, Cheng Peng, Hongbo You, Wentao Zhu, Anmin Chen
Osteoarthritis (OA) is a prevalent joint disorder with inflammatory response and cartilage deterioration as its main features. Dihydrocaffeic acid (DHCA), a bioactive component extracted from natural plant (gynura bicolor), has demonstrated anti-inflammatory properties in various diseases. We aimed to explore the chondroprotective effect of DHCA on OA and its potential mechanism.
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Risk factors for unplanned reoperation after corrective surgery for adult spinal deformity. Bone Joint Res. (IF 4.6) Pub Date : 2023-04-03 Seung-Jun Ryu,Jae-Young So,Yoon Ha,Sung-Uk Kuh,Dong-Kyu Chin,Keun-Su Kim,Yong-Eun Cho,Kyung-Hyun Kim
To determine the major risk factors for unplanned reoperations (UROs) following corrective surgery for adult spinal deformity (ASD) and their interactions, using machine learning-based prediction algorithms and game theory. Patients who underwent surgery for ASD, with a minimum of two-year follow-up, were retrospectively reviewed. In total, 210 patients were included and randomly allocated into training
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The effect of ethnicity on the age-related changes of spinopelvic characteristics: a systematic review. Bone Joint Res. (IF 4.6) Pub Date : 2023-04-01 Kenneth J Lukas,Jeroen C F Verhaegen,Holly Livock,Erik Kowalski,Philippe Phan,George Grammatopoulos
Spinopelvic characteristics influence the hip's biomechanical behaviour. However, to date there is little knowledge defining what 'normal' spinopelvic characteristics are. This study aims to determine how static spinopelvic characteristics change with age and ethnicity among asymptomatic, healthy individuals. This systematic review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses
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TGF-β1 derived from macrophages contributes to load-induced tendon-bone healing in the murine rotator cuff repair model by promoting chondrogenesis. Bone Joint Res. (IF 4.6) Pub Date : 2023-03-10 Linfeng Wang,Shengcan Li,Han Xiao,Tao Zhang,Yuqian Liu,Jianzhong Hu,Daqi Xu,Hongbin Lu
It has been established that mechanical stimulation benefits tendon-bone (T-B) healing, and macrophage phenotype can be regulated by mechanical cues; moreover, the interaction between macrophages and mesenchymal stem cells (MSCs) plays a fundamental role in tissue repair. This study aimed to investigate the role of macrophage-mediated MSC chondrogenesis in load-induced T-B healing in depth. C57BL/6
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Systemic glucose-insulin-potassium reduces skeletal muscle injury, kidney injury, and pain in a murine ischaemia-reperfusion model. Bone Joint Res. (IF 4.6) Pub Date : 2023-03-09 Daniel B Buchalter,David J Kirby,Utkarsh Anil,Sanjit R Konda,Philipp Leucht
Glucose-insulin-potassium (GIK) is protective following cardiac myocyte ischaemia-reperfusion (IR) injury, however the role of GIK in protecting skeletal muscle from IR injury has not been evaluated. Given the similar mechanisms by which cardiac and skeletal muscle sustain an IR injury, we hypothesized that GIK would similarly protect skeletal muscle viability. A total of 20 C57BL/6 male mice (10 control
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Monomeric CRP regulates inflammatory responses in human intervertebral disc cells. Bone Joint Res. (IF 4.6) Pub Date : 2023-03-07 Clara Ruiz-Fernández,Djedjiga Ait Eldjoudi,Maria González-Rodríguez,Alfonso Cordero Barreal,Yousof Farrag,Lucia García-Caballero,Francisca Lago,Ali Mobasheri,Daisuke Sakai,Jesús Pino,Oreste Gualillo
CRP is an acute-phase protein that is used as a biomarker to follow severity and progression in infectious and inflammatory diseases. Its pathophysiological mechanisms of action are still poorly defined. CRP in its pentameric form exhibits weak anti-inflammatory activity. The monomeric isoform (mCRP) exerts potent proinflammatory properties in chondrocytes, endothelial cells, and leucocytes. No data
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Benefit of sunlight and melatonin on back pain and inflammation. Bone Joint Res. (IF 4.6) Pub Date : 2023-03-07 Joanna Brzeszczyńska,Filip Brzeszczyński
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A survey on the usage of decellularized tissues in orthopaedic clinical trials. Bone Joint Res. (IF 4.6) Pub Date : 2023-03-07 Masafumi Itoh,Junya Itou,Shinya Imai,Ken Okazaki,Kiyotaka Iwasaki
Orthopaedic surgery requires grafts with sufficient mechanical strength. For this purpose, decellularized tissue is an available option that lacks the complications of autologous tissue. However, it is not widely used in orthopaedic surgeries. This study investigated clinical trials of the use of decellularized tissue grafts in orthopaedic surgery. Using the ClinicalTrials.gov (CTG) and the International
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Melatonin protects human nucleus pulposus cells from pyroptosis by regulating Nrf2 via melatonin membrane receptors. Bone Joint Res. (IF 4.6) Pub Date : 2023-03-07 Zhibiao Bai,Zeyu Shou,Kai Hu,Jiahuan Yu,Hongming Meng,Chun Chen
This study was performed to explore the effect of melatonin on pyroptosis in nucleus pulposus cells (NPCs) and the underlying mechanism of that effect. This experiment included three patients diagnosed with lumbar disc herniation who failed conservative treatment. Nucleus pulposus tissue was isolated from these patients when they underwent surgical intervention, and primary NPCs were isolated and cultured