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Estimating Lumbar Spine Least Significant Change for Fewer than Four Vertebrae: The Manitoba BMD Registry J. Clin. Densitom. (IF 2.5) Pub Date : 2024-03-06 Harold Rosen, Auryan Szalat, William D. Leslie
: The International Society of Clinical Densitometry recommends omitting lumbar vertebrae affected by structural artifact from spine BMD measurement. Since reporting fewer than 4 vertebrae reduces spine BMD precision, least significant change (LSC) needs to be adjusted upwards when reporting spine BMD change based on fewer than 4 vertebrae.
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Sarcopenia/osteoporosis in obstructive sleep apnea Syndrome: beauty lies in the details J. Clin. Densitom. (IF 2.5) Pub Date : 2024-03-05 Ahmad J. Abdulsalam, Mohammad A. Abdulsalam, Murat Kara
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Nonalcoholic Fatty Liver Disease, Bone and Muscle Quality in Prolactinoma: A Pilot Study J. Clin. Densitom. (IF 2.5) Pub Date : 2024-02-22 İmdat Eroğlu, Burcin Gonul Iremli, Aysegul Erkoc, Ilkay S. Idilman, Deniz Yuce, Ebru Calik Kutukcu, Deniz Akata, Tomris Erbas
: Hyperprolactinemia has negative impacts on metabolism and musculoskeletal health. In this study, individuals with active prolactinoma were evaluated for nonalcoholic fatty liver disease (NAFLD) and musculoskeletal health, which are underemphasized in the literature.
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Risk of Sarcopenia and Osteoporosis in Elderly Male Patients with Obstructive Sleep Apnea Syndrome: A Multicenter Study J. Clin. Densitom. (IF 2.5) Pub Date : 2024-02-17 Zhen Xue, Shengguan Song, Changan Hu, Shanglong Zhao, Juan Wang
The aim of this study was to assess the risk of sarcopenia and osteoporosis in elderly patients with obstructive sleep apnea syndrome (OSAS). We recruited both OSAS patients and non-OSAS subjects from multiple centers and evaluated their skeletal muscle index (SMI), bone mineral density (BMD), and inflammatory factors. All participants underwent polysomnography (PSG) testing, handgrip strength testing
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Performance of Progressive Generations of GPT on an Exam Designed for Certifying Physicians as Certified Clinical Densitometrists J. Clin. Densitom. (IF 2.5) Pub Date : 2024-02-17 Dustin Valdez, Arianna Bunnell, Sian Y. Lim, Peter Sadowski, John A. Shepherd
: Artificial intelligence (AI) large language models (LLMs) such as ChatGPT have demonstrated the ability to pass standardized exams. These models are not trained for a specific task, but instead trained to predict sequences of text from large corpora of documents sourced from the internet. It has been shown that even models trained on this general task can pass exams in a variety of domain-specific
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Bone Health ECHO Case Report: Fractures and Hypercalcemia in a Patient with Stage 5 Chronic Kidney Disease J. Clin. Densitom. (IF 2.5) Pub Date : 2024-02-15 E. Michael Lewiecki, Dale G. Erickson, Roger W. Gildersleeve
Bone Health ECHO (Extension for Community Healthcare Outcomes) is a virtual community of practice with the aim of enhancing global capacity to deliver best practice skeletal healthcare. The prototype program, established at the University of New Mexico, has been meeting online weekly since 2015, focusing on presentation and discussion of patient cases. These discussions commonly cover issues that are
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Osteopenia and Osteoporosis Screening Detection: Calcaneal Quantitative Ultrasound with and without Calibration Factor Comparison to Gold Standard Dual X-ray Absorptiometry J. Clin. Densitom. (IF 2.5) Pub Date : 2024-01-27 Nutthapong Moonkum, Thanat Withayanuluck, Arun Somarungsan, Naphondej Sichai, Arisa Wongsiri, Witchayada Chawkhaodin, Podjana Ruengdach, Pasinee Boonsuk, Marut Pukdeeyorng, Gunjanaporn Tochaikul
Background osteoporosis is a worldwide major health problem that normally diagnosed in advanced stages. So, an early detection at preclinical stage is now an interesting issue. A key factor to early diagnosis the disease is the used of noninvasive bone densitometry. Dual energy x-ray absorptiometry (DXA) is the gold standard techniques for the proposed. However, the high cost, non-widely available
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Effect of calcium and vitamin D supplementation (dairy vs pharmacological) on bone health of Underprivileged Indian children and youth with type-1 diabetes: A Randomized Controlled Trial J. Clin. Densitom. (IF 2.5) Pub Date : 2024-01-26 Dr. Anuradha Khadilkar, Dr. Chirantap Oza, Dr. Misha Antani, Dr. Nikhil Shah, Dr. Nikhil Lohiya, Dr. Vaman Khadilkar, Dr. Shital Bhor, Dr. Neha Kajale, Mr. Ketan Gondhalekar, Dr. Chidvilas More, Dr. Tarun Reddy Katapally, Dr. Zulf Mughal, Dr. Jasmin Bhawra, Dr. Raja Padidela
Background : Bone health is affected by chronic childhood disorders including type-1 diabetes mellitus (T1DM). We conducted this randomized controlled trial with the objective of investigating the effect of 1-year supplementation of vitamin-D with milk or with pharmacological calcium on bone mass accrual in underprivileged Indian children and youth with T1DM. Methods : 5 to 23year old (n=203) underprivileged
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Cafeteria Diet Can Affect Bone Microarchitecture in Sedentary and Trained Male Rats J. Clin. Densitom. (IF 2.5) Pub Date : 2024-01-24 Marcio Koiti Saito, Beatriz Kawano de Oliveira, Ana Paula Macedo, Caio Sorrentino dos Santos, Ricardo Tadeu Lopes, Jéssica Suzuki Yamanaka, Antonio Carlos Shimano
Introduction: Poor eating habits and a sedentary lifestyle can impair health. Regular physical activity improves the quality of life and is essential for bone health. Therefore, the present study aimed to evaluate the effects of the cafeteria diet on bone quality of sedentary and exercised rats. Methods: Sixty young male Wistar rats were divided into six groups (n=10) according to diet composition
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3D-DXA based finite element modelling for femur strength prediction: evaluation against QCT. J. Clin. Densitom. (IF 2.5) Pub Date : 2024-01-24 Muhammad Qasim, Mirella López Picazo, Carlos Ruiz Wills, Jérôme Noailly, Silvana Di Gregorio, Luis Miguel Del Río Barquero, Jorge Malouf Sierra, Ludovic Humbert
Osteoporosis is characterised by the loss of bone density resulting in an increased risk of fragility fractures. The clinical gold standard for diagnosing osteoporosis is based on the areal bone mineral density (aBMD) used as a surrogate for bone strength, in combination with clinical risk factors. Finite element (FE) analyses based on quantitative computed tomography (QCT) have been shown to estimate
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Development and validation of a nomogram model for individualizing the risk of osteopenia in abdominal obesity J. Clin. Densitom. (IF 2.5) Pub Date : 2024-01-24 Gangjie Wu, Chun Lei, Xiaobing Gong
This study was aimed to create and validate a risk prediction model for the incidence of osteopenia in individuals with abdominal obesity.
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Dual-energy X-ray absorptiometry does not confirm validity of the Craig's test J. Clin. Densitom. (IF 2.5) Pub Date : 2024-01-09 Kelsey A. Clark, Savannah Nielsen, Taylor Heywood, Camille Nguyen, Ulrike H. Mitchell
The Craig's test is a clinical assessment used to quantify femoral version. The validity of the Craig's test has been called into question due to instances where the test exhibits relatively poor correlation with three-dimensional imaging. Our study purpose was to use dual-energy X-ray absorptiometry (DXA) to indirectly assess the validity of the Craig's test. Twenty-three volunteers (n = 46; each
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Vertebral Fracture Risk Thresholds from Phantom-Less Quantitative Computed Tomography-Based Finite Element Modeling Correlate to Phantom-Based Outcomes J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-19 Maria Prado, Sundeep Khosla, Hugo Giambini
Introduction: Osteoporosis indicates weakened bones and heightened fracture susceptibility due to diminished bone quality. Dual-energy x-ray absorptiometry is unable to assess bone strength. Volumetric bone mineral density (vBMD) from quantitative computed tomography (QCT) has been used to establish guidelines as equivalent measurements for osteoporosis. QCT-based finite element analysis (FEA) has
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Quantitative CT Evaluation of Bone Mineral Density in the Thoracic Spine on 18F-Fluorocholine PET/CT Imaging in Patients With Primary Hyperparathyroidism J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-13 Erik T. te Beek, Chris P.W. van Duijnhoven, Riemer H.J.A. Slart, Joop P. van den Bergh, Marc R.J. ten Broek
Introduction: Measurement of bone mineral density (BMD) with quantitative CT (QCT) carries several advantages over other densitometric techniques, including superior assessment of the spine. As most QCT studies evaluated the lumbar spine, measurements of the thoracic spine are limited. We performed QCT analysis of the thoracic spine in a cohort of patients with primary hyperparathyroidism. Materials
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Two Pathological fractures in a patient with chronic abnormalities in serum markers following two liver transplantations: A case report and literature review J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-12 Feng Wang, Jia Gao, Zheng-Ye Wang, Tang-Bo Yuan, Da-Wei Cai, Hua Wan, Jian Qin
Bone disease is a common complication following liver transplantation, often overlooked in clinical practice. Clinical diagnosis of post-liver transplantation bone disease is challenging, and there have been few case report in the literature. This case report presents a patient who underwent two liver transplant surgeries, exhibited good daily activity, and did not display typical clinical symptoms
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The Effect of a Compression Bandage on Dual Energy X-ray Absorptiometry Body Composition Scores J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-09 Yamileth Chacón-Araya, Elizabeth Carpio-Rivera, Andrea Quirós-Quirós, José Moncada-Jiménez
Background: Dual-energy X-ray absorptiometry (DXA) measures are affected by the noise produced by external factors such as textile compression found in loose clothing. The study aimed to determine the effect of a compression bandage (CB) on body composition (BC) assessed by DXA. Methods: Sixty volunteers (age=21.4±4.7yr.) underwent full-body DXA scans on a control (CTRL) condition and after wearing
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Fixed and Relative Positioning of Scans for High Resolution Peripheral Quantitative Computed Tomography J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-09 Annabel R. Bugbird, Rachel E. Klassen, Olivia L. Bruce, Lauren A. Burt, W. Brent Edwards, Steven K. Boyd
Introduction: High resolution peripheral quantitative computed tomography (HR-pQCT) imaging protocol requires defining where to position the ∼1 cm thick scan along the bone length. Discrepancies between the use of two positioning methods, the relative and fixed offset, may be problematic in the comparison between studies and participants. This study investigated how bone landmarks scale linearly with
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Fracture Risk with Modified FRAX in Men Living with HIV J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-07 Alline Peralta Castro, Kamylla Batista Brito, Thirza Damasceno Ramos Oliva, Isabella Mesquita Sfair Silva, Beatriz de Souza Kato, Gisele Alves Morikawa Caldeira, Flávia Marques Santos, Rosana Maria Feio Libonati
Background: Aging of the HIV-infected population and prolonged use of ARTs, produced metabolic alterations, including increased fracture risk. FRAX is a validated, computer-based clinical fracture risk calculator which estimates 10-year risk of major fracture, and hip fracture. However may underestimate risk in HIV-infected individuals. Several experts recommend considering HIV a cause of secondary
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National Survey of the Bone Densitometry Evaluation Process Within an Integrated Healthcare System J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-06 Melissa J.A. Steffen, Kimberly D. McCoy, Michelle A. Mengeling, Karla L. Miller, Heather Davila, Shylo E. Wardyn, Amal Shibli-Rahhal, Irfan Farukhi, Samantha L. Solimeo
Background: To assess the current state of bone mineral density evaluation services via dual energy x-ray absorptiometry (DXA) provided to Veterans with fracture risk through the development and administration of a nationwide survey of facilities in the Veterans Health Administration. Methodology: The Bone Densitometry Survey was developed by convening a Work Group of individuals with expertise in
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Dual Energy X-ray Absorptiometry: Radiographer'S Role in Assessing Fracture Risk Assessment Tool (FRAX) Questionnaire Variables J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-06 Moreno Zanardo, Cinzia Mennini, Pierluigi Glielmo, Stefano Fusco, Domenico Albano, Carmelo Messina
Background: The FRAX® algorithm is a tool used to calculate the 10-year probability of fracture in patients with osteoporosis and is based the assessment of several risk factors. We assessed the performance and accuracy of the completion of the FRAX® anamnestic questionnaire by the radiographer without impact on the clinical workflow. Methodology: We evaluated the accuracy of fracture risk calculation
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Clinical Use of Trabecular Bone Score: The 2023 ISCD Official Positions J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-05 Heenam Goel, Neil Binkley, Miranda Boggild, Wing P. Chan, William D. Leslie, Eugene McCloskey, Sarah L. Morgan, Barbara C. Silva, Angela M. Cheung
Osteoporosis can currently be diagnosed by applying the WHO classification to bone mineral density (BMD) assessed by dual-energy x-ray absorptiometry (DXA). However, skeletal factors other than BMD contribute to bone strength and fracture risk. Lumbar spine TBS, a grey-level texture measure which is derived from DXA images has been extensively studied, enhances fracture prediction independent of BMD
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Dual-energy X-ray Absorptiometry Trends Among US Medicare Beneficiaries: 2005–2019 J. Clin. Densitom. (IF 2.5) Pub Date : 2023-12-01 Tyler Prout, Casey Pelzl, Eric W. Christensen, Neil Binkley, John Schousboe, Diane Krueger
Introduction: Bone density measured using dual-energy X-ray absorptiometry (DXA) volume, performance site and interpreters have changed in the US since 2005. The purpose of this report is to provide updated trends in DXA counts, rates, place of service and interpreter specialty for the Medicare fee-for-service population. Methods: The 100 % Medicare Physician/Supplier Procedure Summary Limited Data
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Meta-Analysis on the Association Between DPP-4 Inhibitors and Bone Mineral Density and Osteoporosis J. Clin. Densitom. (IF 2.5) Pub Date : 2023-11-28 Lili Huang, Wei Zhong, Xinghuan Liang, Huijuan Wang, Shi-en Fu, Zuojie Luo
Background Type 2 Diabetes Mellitus (T2DM) frequently coexists with osteoporosis and reduced bone mineral density (BMD). Dipeptidyl peptidase-4 inhibitors (DPP-4i), a class of antihyperglycemic agents, are commonly employed in T2DM treatment. However, the influence of DPP-4i on bone health remains unclear and debated. This meta-analysis is conducted to explore the relationship between the use of DPP-4i
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Hyperprolactinemia Due to Prolactinoma has an Adverse Impact on Bone Health with Predominant Impact on Trabecular Bone: A Systematic Review and Meta-Analysis J. Clin. Densitom. (IF 2.5) Pub Date : 2023-11-25 Lakshmi Nagendra, Deep Dutta, Sunetra Mondal, Nitin Kapoor, Ameya Joshi, Saptarshi Bhattacharya
Background: No meta-analysis has holistically analysed and summarized the effect of prolactin excess due to prolactinomas on bone mineral metabolism. We undertook this meta-analysis to address this knowledge-gap. Methods: Electronic databases were searched for studies having patients with hyperprolactinemia due to prolactinoma and the other being a matched control group. The primary outcome was to
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Effects of the Type of Exercise Training on Bone Health Parameters in Adolescent Girls: A Systematic Review J. Clin. Densitom. (IF 2.5) Pub Date : 2023-11-24 Abdel Jalil Berro, Wassim El Hawly, Gisèle El Khoury, Zaher El Hage, Ayyappan Jayavel, Ayoub Saeidi, Ismail Laher, Antonio Pinti, Youssef Bassim, Anthony C. Hackney, Urs Granacher, Hassane Zouhal, Rawad El Hage
Interventional studies offer strong evidence for exercise's osteogenic impact on bone particularly during growth. With rising osteoporosis rates in older women, enhancing bone strength early in life is crucial. Thus, investigating the osteogenic effects of different types of physical activities in young females is crucial. Despite varied findings, only two systematic reviews tried to explore this topic
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Evaluation of Bone Mineral Changes in Panoramic Radiographs of Hypothyroid and Hyperthyroid Patients Using Fractal Dimension Analysis J. Clin. Densitom. (IF 2.5) Pub Date : 2023-11-16 Elif Meltem Aslan Ozturk, Aslihan Artas
Objective Hyperthyroidism and hypothyroidism are endocrinopathies that cause a decrease in bone mineral density. The aim of this study is to investigate possible bone changes in the mandible caused by hyperthyroidism and hypothyroidism using fractal analysis (FA) on panoramic radiographs. Material and Methods Panoramic radiographs of a total of 180 patients, including 120 patient groups (60 hyperthyroid
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Based on HbA1c Analysis: Bone Mineral Density and Osteoporosis Risk in Postmenopausal Female with T2DM J. Clin. Densitom. (IF 2.5) Pub Date : 2023-11-04 Lei Gao, Ying Liu, Min Li, Yan Wang, Wei Zhang
Introduction: This study aims to investigate association between glycosylated hemoglobin (HbA1c) with bone mineral density (BMD) and osteoporosis-risk in postmenopausal female with type 2 diabetes mellitus (T2DM). Methodology: HbA1c values, BMD of L3 vertebra and basic clinical data of 152 postmenopausal females with T2DM and 326 postmenopausal females without T2DM were retrospectively analyzed. The
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Bone mineral density derived from cardiac CT scans: Using contrast enhanced scans for opportunistic screening J. Clin. Densitom. (IF 2.5) Pub Date : 2023-11-03 Andia Cheneymann, Josephine Therkildsen, Simon Winther, Louise Nissen, Jesper Thygesen, Bente L. Langdahl, Ellen-Margrethe Hauge, Morten Bøttcher
Purpose: Osteoporosis is under-diagnosed and often co-exists with other diseases. Very low bone mineral density (BMD) indicates risk of osteoporosis and opportunistic screening for low BMD in CT-scans has been suggested. In a non-contrast enhanced thoracic CT scan, the scan-field-of-view includes vertebrae enabling BMD estimation. However, many CT scans are obtained by administration of contrast material
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Reporting of Full-Femur Length Images to Detect Incomplete Atypical Femoral Fracture: 2023 Official Positions of the International Society for Clinical Densitometry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-10-31 Adrian Lau, Tyler Prout, Alan Malabanan, Auryan Szalat, Diane Krueger, S. Bobo Tanner, Harold Rosen, Christopher Shuhart
Incomplete atypical femur fractures (iAFFs) are associated with the long-term use of anti-resorptive therapies. Although X-rays are typically used to screen for iAFFs, images from dual-energy X-ray absorptiometry (DXA) offer an alternate method for detecting iAFFs. Although a previous 2019 ISCD Official Position on this subject exists, our task force aimed to update the literature review and to propose
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DXA Reporting Updates: 2023 Official Positions of the International Society for Clinical Densitometry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-11-02 Diane Krueger, S. Bobo Tanner, Auryan Szalat, Alan Malabanan, Tyler Prout, Adrian Lau, Harold N. Rosen, Christopher Shuhart
Introduction: Professional guidance and standards assist radiologic interpreters in generating high quality reports. Initially DXA reporting Official Positions were provided by the ISCD in 2003; however, as the field has progressed, some of the current recommendations require revision and updating. This manuscript details the research approach and provides updated DXA reporting guidance. Methods: Key
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Follow-up bone mineral density testing: 2023 official positions of the International Society for Clinical Densitometry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-11-02 Linsey U. Gani, Chanika Sritara, Robert D. Blank, WeiWen Chen, Julia Gilmour, Ruban Dhaliwal, Ranjodh Gill
Dual-energy X-ray absorptiometry (DXA) is the gold standard method for measuring bone mineral density (BMD) which is most strongly associated with fracture risk. BMD is therefore the basis for the World Health Organization's densitometric definition of osteoporosis. The International Society for Clinical Densitometry (ISCD) promotes best densitometry practices and its official positions reflect critical
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Bilateral Hip DXA Reporting: 2023 Official Positions of the International Society for Clinical Densitometry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-10-31 S. Bobo Tanner, Diane Krueger, Auryan Szalat, Tyler Prout, Adrian Lau, Alan Malabanan, Harold Rosen, Christopher Shuhart
Introduction : This position development conference (PDC) Task Force examined the use and reporting of bilateral hip bone mineral density (BMD) measurements. This was deemed appropriate as increased availability of DXA technology offering bilateral hip measurement resulted in more routine clinical use. The International Society for Clinical Density Official Positions accept bilateral hip BMD measurement
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Executive Summary of the 2023 Adult Position Development Conference of The International Society for Clinical Densitometry: DXA Reporting, Follow-up BMD Testing and Trabecular Bone Score Application and Reporting J. Clin. Densitom. (IF 2.5) Pub Date : 2023-10-31 Christopher Shuhart, Angela Cheung, Ranjodh Gill, Linsey Gani, Heenam Goel, Auryan Szalat
After 15 months of preparation by task force chairs and teams, ISCD's 9th Position Development Conference (PDC) convened in Northbrook, IL, USA on March 28th and 29th, 2023 to approve new ISCD Official Positions in the topic areas of DXA Reporting, Follow-up BMD Testing and TBS Application and Reporting. Three teams of participants work to bring the PDC to fruition: the Steering Committee, Task Forces
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Reporting Fewer Than Four Vertebrae: 2023 Official Positions of the International Society for Clinical Densitometry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-10-31 Harold Rosen, Adrian Lau, Auryan Szalat, S. Bobo Tanner, Diane Krueger, Tyler Prout, Alan Malabanan, Christopher Shuhart
The precision for spine bone mineral density (BMD) worsens as vertebrae are excluded, so recommendations are needed for least significant change (LSC) for spine BMDs based on fewer than 4 vertebrae. The task force recommends re-analysis of each facility's L1-L4 in-house precision study to determine the precision in order to calculate the LSC for each combination of 2 or 3 reported vertebrae. The task
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Cross-Calibration Study of The Stratos And Hologic QDR 4500A Dual-Energy X-Ray Absorptiometers to Assess Bone Mineral Density And Body Composition J. Clin. Densitom. (IF 2.5) Pub Date : 2023-10-28 Laurent Maïmoun, Sandrine Alonso, Krishna Kunal Mahadea, Vincent Boudousq, Thibault Mura, Denis Mariano-Goulart
The objective of the study was to assess the agreement between the Stratos (DMS) and QDR 4500A (Hologic) DXAs in determining whole body and regional aBMD, as well as whole body composition. Fifty-five individuals (46 women: 84%) with a mean age of 41 ± 13.0 years (range: 20 to 64) and a mean BMI of 31.9 ± 10 kg/m² (range: 12.2 to 49.5) were consecutively scanned on the same day using the two devices
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Proceedings of the 2023 Santa Fe bone symposium: Progress and controversies in the management of patients with skeletal diseases J. Clin. Densitom. (IF 2.5) Pub Date : 2023-10-14 E. Michael Lewiecki, Teresita Bellido, John P. Bilezikian, Jacques P. Brown, Azeez Farooki, Christopher S. Kovacs, Brendan Lee, William D. Leslie, Michael R. McClung, Mark L. Prasarn, Deborah E. Sellmeyer
The Santa Fe Bone Symposium (SFBS) held its 23rd annual event on August 5-6, 2023, in Santa Fe, New Mexico, USA. Attendees participated in-person and remotely, representing many states and countries. The program included plenary presentations, panel discussions, satellite symposia, a Project ECHO workshop, and a session on healthcare policy and reimbursement for fracture liaison programs. A broad range
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Effects of severe lumbar spine structural artifact on trabecular bone score (TBS): The Manitoba BMD Registry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-10-08 William D. Leslie, Neil Binkley, Didier Hans
Trabecular bone score (TBS) is a bone mineral density (BMD)-independent risk factor for fracture. During DXA analysis and BMD reporting, it is standard practice to exclude lumbar vertebral levels affected by structural artifact. Although TBS is relatively insensitive to degenerative artifact, it is uncertain whether TBS is still useful in the presence extreme structural artifact that precludes reliable
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Is there a correlation between radiographic absorptiometry of the phalanges of the hand and radiomorphometric indices of the mandible? J. Clin. Densitom. (IF 2.5) Pub Date : 2023-10-05 Ângela Jordão Camargo, Giovani Antonio Rodrigues, Plauto Christopher Aranha Watanabe
Objectives: The aim of this study was to correlate the mandibular bone quality through radiomorphometric indices in panoramic radiograph with bone quality of non-dominant hand phalanges by radiographic absorptiometry phalanx (RA). Methods: The sample consisted of 167 patients (128 women and 39 men) with a mean age of 52.09 (± 11.5) divided into four groups according to RA test: (A) 92; (B) 36; (C)
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FRAX® adjustment using renormalized trabecular bone score (TBS) from L1 alone may be optimal for fracture prediction: The Manitoba BMD registry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-09-14 William D. Leslie, Neil Binkley, Heenam Goel, Eugene V. McCloskey, Didier Hans
Lumbar spine trabecular bone score (TBS) used in conjunction with FRAX® improves 10-year fracture prediction. The derived FRAX risk adjustment is based upon TBS measured from L1-L4, designated TBSL1-L4-FRAX. In prior studies, TBS measurements that include L1 and exclude L4 give better fracture stratification than L1-L4. We compared risk stratification from TBS-adjusted FRAX using TBS derived from different
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Adjusting Trabecular Bone Score (TBS) for level-specific differences reduces FRAX®-based treatment reclassification in patients with vertebral exclusions: The Manitoba BMD Registry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-09-09 William D. Leslie, Neil Binkley, Heenam Goel, Didier Hans, Eugene V. McCloskey
Trabecular bone score (TBS) is a FRAX®-independent risk factor for fracture prediction. TBS values increase from cranial to caudal, with the following mean differences between TBSL1-L4 and individual lumbar vertebrae: L1 −0.093, L2 −0.008, L3 +0.055 and L4 +0.046. Excluding vertebral levels can affect FRAX-based treatment recommendations close to the intervention threshold. We examined the effect of
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6 year old with Duchenne's Muscular Dystrophy with extremely low BMD and BMC calculations secondary to local edema from acute vertebral fracture J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Virginia A. Kaperick
Case Description 6 year old with Duchenne's Muscular Dystrophy (DMD), on chronic daily glucocorticoids, presented for his scheduled DXA screening, as per 2018 DMD Care Considerations Guidelines. He fell on his bottom the night before his appointment resulting in acute severe midline low back pain. GE Lunar iDXA densitometer was unable to automatically detect bone edges requiring manual ROI placement
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The relationship between entered height, weight, sex, and changes in patient thickness on Trabecular Bone Score using a Hologic Horizon Dual Energy X-ray Bone Densitometer - A cadaveric spine phantom study J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Lawrence G. Jankowski, Michelle Kochanski, Ami K. Kothari
Purpose/Aims To explore the sensitivity and precision of Trabecular Bone Score (TBS) calculations to changes in the entered weight, height, sex, and scan mode on a Hologic Horizon-A densitometer, using a radiographic cadaveric spine torso phantom. Rationale/Background Currently, TBS adjusts the score using BMI of the patient, using calibration points derived from a TBS Calibration Phantom that has
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Dual-energy X-ray Performance Among Medicare Beneficiaries: 2005-2019 J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Tyler Prout, Casey E. Pelzl, Eric W. Christensen, Neil Binkley, John Schousboe, Diane Krueger
Purpose/Aims To provide updated trends in DXA number, utilization rates, place of service and interpreter specialty based on a Medicare population dataset. Rationale/Background DXA exam utilization rate, place of service and interpreters have changed since 2005. Methods The Medicare Physician/Supplier Procedure Summary Limited Data Set between 2005-2019 was used. All claims with CPT DXA codes 76075
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Body composition comparison between Horizon A System and Lunar iDXA: The OsteoLaus Cohort J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Colin Vendrami, Enisa Shevroja, Guillaume Gatineau, Elena Gonzalez Rodriguez, Lamy Olivier, Didier Hans
Purpose/Aims This study aims to compare body composition measures between two different devices of latest generation: Horizon A SystemTM (Hologic, Waltham, MA, USA) and Lunar iDXATM (GE Healthcare, Madison, Wi, USA). Rationale/Background Dual-energy X-Ray Absorptiometry (DXA) is one of the reference techniques for the assessment of body composition thanks to its reliability, low irradiation, and the
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Medical imaging measurement of visceral adipose tissue thresholds associated with increased risk of cardiometabolic disease J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Jonathan Bennett, Michael Wong, Carla Prado, Steven Heymsfield, John Shepherd
Purpose/Aims Identify visceral adipose tissue (VAT) thresholds associated with increased cardiometabolic disease risk. Rationale/Background Beyond overall obesity, VAT storage is associated with adverse metabolic parameters that increase the risk of heart disease, stroke, and type II diabetes. Computed tomography (CT) and magnetic resonance imaging (MRI) technologies have been used to define thresholds
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Fragility Fracture Network Malaysia (FFNM) Fracture Liaison Service (FLS) Framework FFNM promotes multidisciplinary approach on fragility fracture care. It aims to create a national network of fragility fracture care. FLS is a relatively new approach fragility fracture care in Malaysia. The Framework functions as a systematic guide to achieve these goals. It provides a common platform for all FLS to J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 JOON KIONG LEE, ELIZABETH GAR MIT CHONG, JULIA PATRICK ENGKASAN, SITI NURBAYA MOHD NAWI, TERENCE ONG, SANKARA KUMAR CHANDRASEKARAN, PAUL JAMES MITCHELL
Purpose/Aims FFNM aims to create a national network of fragility fracture care, with the participation of various clinical specialists, allied health and primary care physician from different states throughout Malaysia. Fracture Liaison Service (FLS) is a relatively new approach and platform promoting fragility fracture care in Malaysia. Rationale/Background The Fragility Fracture Network of Malaysia
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Implementation of Body Composition Analysis for Athletes at an Academic Medical Center J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Brian S. Englander, Chris Dehney
Purpose/Aims The purpose is to describe the process for creation and implementation of a body composition analysis program within an academic medical center for evaluation of elite athletes pre-, mid-, and post-season, as well as after injury. Rationale/Background Body composition analysis is an accepted technique for measurement of muscle, fat, and bone strength that has been possible for more than
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Atypical Femur Fracture on Denosumab and Prednisone with Multiple Vertebral Compression Fractures, Frailty and Diminishing Quality of Life J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Gayle Frazzetta
Case Description Atypical Femur Fracture on Denosumab and Prednisone with Multiple Vertebral Compression Fractures, Frailty, and Diminishing Quality of Life CO is a 70yo female with end-stage O2 and steroid dependent COPD/asthma with multiple thoracic and lumbar compression fractures contributing/causing non-ambulatory status and impairment of ADL's. She was treated with denosumab(Prolia) 2011-2015
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A Collaborative Approach to Bone Health J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 SHIBI A. Kunjumon
Purpose/Aims Background: Osteoporosis is a global problem; people living with osteoporosis have increased dramatically in the last few decades due to the aging population and changes in lifestyle. The project aims to improve post-fracture care and use a preventative service for compromised bone quality patients in the Emergency Room (ER). The QI project aims to increase ER providers' awareness about
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Effect of Testosterone Pellet Therapy on Bone Mineral Density in Postmenopausal Women J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Gayle Frazzetta
Purpose/Aims Estrogen therapies have been proven efficacious for the improvement of BMD and fracture risk reduction. Estradiol(E2) and testosterone(T) therapy using pellets have been shown to improve BMD. Current trends in hormone pellet therapy include T with minimal or no E2. Lower doses of E2 minimize the occurrence of adverse effects such as vaginal bleeding, fibroid enlargement, bloating, and
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Intraoperative Physician Assessment during total hip arthroplasty correlates with DXA parameters J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 David P. Martin, Samuel S. Lake, Michael A. Behun, Diane Krueger, Radius Neil Binkley, David Hennessy, Brian Nickel
Purpose/Aims To evaluate Intraoperative Physician Assessment (IPA) during total hip arthroplasty (THA) as a quantitative measure of bone status based on tactile assessment. IPA was compared to DXA-measured bone mineral density (BMD), 3D-Shaper parameters, and radiographic indices to assess its validity for evaluating bone status. Rationale/Background The International Society for Clinical Densitometry
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Precision of DXA-derived Visceral Adipose Tissue Measures in Children and their associations J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Devon Cataldi, John Shepherd, Struan Grant, Heidi Kalkwarf, Leila Kazemi, Andrea Kelly, Shana McCormack, Jonathan Mitchell, Brandon Quon, Babette Zemel
Purpose/Aims To investigate the precision and analysis protocol for VAT, SAT, and VAT/SAT ratio and explore precision covariates in a large prospective sample of children and young adults. Rationale/Background Visceral adipose tissue (VAT) has been linked to poor metabolic health, including obesity and metabolic syndrome. Excess VAT can have an early onset during childhood. VAT measured by DXA has
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Custom Femur and Tibia BMD Precision in Elective Total Knee Arthroplasty Patients J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Lucas Andersen, Diane Krueger, Gretta Borchardt, Brian Nickel, Paul A. Anderson, Neil Binkley
Purpose/Aims To compare bone mineral density (BMD) precision of knee custom regions of interest (ROI) with and without total knee arthroplasty (TKA). Rationale/Background TKA is a common procedure that results in 10 to 15% BMD loss at the distal femur. This could contribute to complications such as periprosthetic fracture, especially if osteoporosis is present at the time of TKA. Prior work supports
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Effects of Abaloparatide or Placebo on Bone Mineral Density in Acetabular Regions Corresponding to DeLee and Charnley Zones in Postmenopausal Women with Osteoporosis J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Neil P. Sheth, Mathias P. Bostrom, Renaud Winzenrieth, Ludovic Humbert, Leny Pearman, John Caminis, Yamei Wang, John I. Boxberger, Kelly Krohn
Purpose/Aims To evaluate the effects of 6 and 18 mo of abaloparatide (ABL) compared with placebo (PBO) on bone mineral density (BMD) in the acetabular regions of postmenopausal women with osteoporosis (OP). Rationale/Background Acetabular bone loss, as may occur in OP, increases risk of acetabular fragility fractures and is associated with significant morbidity. In total hip arthroplasty (THA), low
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Abaloparatide Increases Bone Mineral Density in Regions Corresponding to Gruen Zones 1, 2, 6, and 7 in Postmenopausal Women With Osteoporosis J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Neil P. Sheth, Renaud Winzenrieth, Ludovic Humbert, Paul J. Kostenuik, Yamei Wang, John I. Boxberger, Mathias P. Bostrom
Purpose/Aims We hypothesized that local improvements in bone mineral density (BMD) would be observed following 6 and 18 mo of abaloparatide versus placebo in hip regions corresponding to femoral Gruen zones that influence the fixation and stability of femoral stems in hip arthroplasty. Rationale/Background Low BMD at the time of total hip arthroplasty (THA) increases the risk of compromised implant
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The Importance of Bone/Tissue Area Selection in the Clinical Practice of Dual Energy X-ray Absorptiometry J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Yue Zhang, Xinhui Duan, Satyanarayana Chekuri, Dogan Polat, Nicole Barnett, Misty Spracklen, Orhan Oz
Purpose/Aims To demonstrate the bone/tissue area selection in dual energy X-ray absorptiometry (DXA) practice significantly affect the bone mineral density (BMD) quantification. Rationale/Background Worldwide DXA is the most widely applied method for BMD assessment. It is applied for purposes of diagnostic classification and response to therapy. To best serve patients, it requires understanding of
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Periprosthetic Fractures: The Unappreciated Osteoporosis Crisis J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Diane Krueger, Kristyn Hare, Gretta Borchardt, James Bernatz, Neil Binkley, Paul A. Anderson, Paul S. Whiting
Purpose/Aims To describe osteoporosis-related demographics in patients with periprosthetic fracture (PPFx) seen by a university-based orthopedic practice. Rationale/Background Total joint replacement is common and increasing. Many total joint replacement patients have low bone density preoperatively and arthroplasty leads to bone loss. Additionally, falls are common before and after arthroplasty. Thus
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Factors affecting Patient Compliance in the Treatment of Osteoporosis. J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Madhu Pamganamamula, Srinidhi Manchiraju, Harshavardhini Kommavarapu, Gowtham Dronavalli, Tejasvi Pamg
Purpose/Aims To evaluate the incidence of patients declining osteoporotic pharmacologic treatment and to identify factors affecting patient refusal or deferment of treatment options. Rationale/Background Patient consumption of recent literature on the side effects of osteoporosis treatment protocols has dropped the usage of medications such as bisphosphonates by as much as half. This has posed a considerable
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Association of single nucleotide polymorphism of ERα gene and aromatase inhibitor-associated musculoskeletal symptoms J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Yulian Yin, Yue Zhou, Yiwei Fan, Hongfeng Chen
Purpose/Aims The purpose of this study was to investigate the correlation between aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) and ERα gene rs9340799,rs2234693 single nucleotide polymorphisms (SNPs) in breast cancer. Rationale/Background Aromatase inhibitor (AI) has a better effect on adjuvant therapy of hormone receptor-positive (HR+) breast cancers. AIs inhibit aromatase activity
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Survival Analysis of Skeletal Related Events in HR+ Breast Cancer Patients Based on Single NucleotidePolymorphism of ERα Gene J. Clin. Densitom. (IF 2.5) Pub Date : 2023-08-01 Yulian Yin, Yiwei Fan, Meiling Chu, Hongfeng Chen
Purpose/Aims To investigate the correlation between the occurrence of G and C alleles at rs9340799 and rs2234693 of the ERα gene and the occurrence and development of bone metastasis and skeletal related events (such as bone pain, pathological fracture and osteoporosis) in HR+ breast cancer patients. Rationale/Background Endocrine therapy is the mainstay of treatment in HR+ breast cancers, accounting