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Torsion constants and virtual mechanical tests are valid image‐based surrogate measures of ovine fracture healing J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-16 Tianyi Ren, Brendan Inglis, Salim Darwiche, Hannah L. Dailey
In large animal studies, the mechanical reintegration of the bone fragments is measured using postmortem physical testing, but these assessments can only be performed once, after sacrifice. Image‐based virtual mechanical testing is an attractive alternative because it could be used to monitor healing longitudinally. However, the procedures and software required to perform finite element analysis (FEA)
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Age‐dependent changes in collagen crosslinks reduce the mechanical toughness of human meniscus J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-16 Derek Q. Nesbitt, Xinzhu Pu, Matthew W. Turner, Anamaria G. Zavala, Laura Bond, Julia T. Oxford, Trevor J. Lujan
The mechanical resilience of the knee meniscus is provided by a group of structural proteins in the extracellular matrix. Aging can alter the quantity and molecular structure of these proteins making the meniscus more susceptible to debilitating tears. In this study, we determined the effect of aging on the quantity of structural proteins and collagen crosslinks in human lateral meniscus, and examined
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Longitudinal CT‐based finite element analyses provide objective fracture healing measures in an ovine tibia model J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-14 Carla Hetreau, Dominic Mischler, Jérôme Schlatter, Alessia Valenti, Manuela Ernst, Peter Varga, Peter Schwarzenberg
Measuring the healing status of a bone fracture is important to determine the clinical care a patient receives. Implantable devices can directly and continuously assess the healing status of fracture fixation constructs, while subject‐specific virtual biomechanical tests can noninvasively determine callus structural integrity at single time points. Despite their potential for objectification, both
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A statistical analysis of human talar shape and bone density distribution J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-14 Jordan Stolle, Christine M. Harper, Kristyn K. Voegele, Ahmad R. Najafi, Mehrangiz Taheri, Joshua MacBain, Sorin Siegler
The shape of the talus, its internal structure, and its mechanical properties are important in determining talar behavior during loading, which may be significant for the design of surgical tools and implants. Although recent studies using statistical shape modeling have described quantitative talar external shape variation, no similar quantitative study exists to describe the density distribution
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Disease severity versus pain severity: Range of motion differences during single‐ and multiplanar tasks in women with carpometacarpal osteoarthritis J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-14 Tamara Ordonez Diaz, Samuel Licht, Thomas W. Wright, Jennifer A. Nichols
In carpometacarpal osteoarthritis (CMC OA) of the thumb, to what extent treatments should be directed by radiographic disease severity versus pain‐based indicators remains an open question. To address this gap, this study investigated the relative impact of disease severity and pain severity on the range of motion in participants with CMC OA. We hypothesized larger differences would exist between extremes
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Progression of partial to complete ruptures of the Achilles tendon during rehabilitation: A study using a finite element model J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-13 Pedro Diniz, Carlos Quental, Hélder Pereira, Rodrigo Lopes, Gino M. M. J. Kerkhoffs, Frederico C. Ferreira, João Folgado
Substantial research on complete Achilles tendon ruptures is available, but guidance on partial ruptures is comparatively sparse. Conservative management is considered acceptable in partial tendon ruptures affecting less than 50% of the tendon's width, but supporting experimental evidence is currently lacking. Using a previously validated finite element model of the Achilles tendon, this study aimed
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Interfragmentary compression force and fixation stability of lateral tibial plateau fractures in normal and osteoporotic bones J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-13 Jiang Jiang, Daqiang Xu, Zhenhua Ji, Rui Jia, Fei Wang, Jinchuan Tan, Hong Hong, Jianyi Li
Lateral platform collapse in fixations of lateral tibial plateau fractures (TPFs) using either double‐lag screws fixation (DSF) or locking‐plate fixation (LPF) is not rare. This study aimed to explore the effect of enhancing the interfragmentary compression force (IFCF) on fixation stability in lateral TPFs in normal and osteoporotic bones using finite element analysis. Finite element models of DSF
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Minimal but potentially clinically relevant anteroinferior position of the humeral head following traumatic anterior shoulder dislocations: A 3D‐CT analysis J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-11 Lukas P. E. Verweij, Johannes G. G. Dobbe, Gino M. M. J. Kerkhoffs, Geert J. Streekstra, Michel P. J. van den Bekerom, Leendert Blankevoort, Derek F. P. van Deurzen
In unstable shoulders, excessive anteroinferior position of the humeral head relative to the glenoid can lead to a dislocation. Measuring humeral head position could therefore be valuable in quantifying shoulder laxity. The aim of this study was to measure (1) position of the humeral head relative to the glenoid and (2) joint space thickness during passive motion in unstable shoulders caused by traumatic
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Cigarette smoke extract exacerbates progression of osteoarthritic‐like changes in cartilage explant cultures J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-10 Emily Sawvell DiNicola, Andrea Vera Martinez, Lizzie Walker, Yongren Wu, Brian G. Burnikel, Jeremy Mercuri
Established risk factors for osteoarthritis (OA) include obesity, joint injury, age, race, and genetics. However, the relationship between cigarette smoking and OA has yet to be established. In the present study, we have employed the use of cigarette smoke extract (CSE), the water‐soluble vapor phase of cigarette smoke, with porcine cartilage explants to investigate the effects of cigarette smoking
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Mechanobiology of bacterial biofilms: Implications for orthopedic infection J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-03 Margaux Blondel, Camille Machet, Britt Wildemann, Yara Abidine, Pascal Swider
Postoperative bacterial infections are prevalent complications in both human and veterinary orthopedic surgery, particularly when a biofilm develops. These infections often result in delayed healing, early revision, permanent functional loss, and, in severe cases, amputation. The diagnosis and treatment pose significant challenges, and bacterial biofilm further amplifies the therapeutic difficulty
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Increased Wnt5a/ROR2 signaling is associated with chondrogenesis in meniscal degeneration J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-05 Yusuke Inoue, Ken Kumagai, Kimi Ishikawa, Ikuma Kato, Youhei Kusaba, Takuma Naka, Kiyotaka Nagashima, Hyonmin Choe, Hiroyuki Ike, Naomi Kobayashi, Yutaka Inaba
The aim of the present study was to investigate the association between chondrogenic differentiation and Wnt signal expression in the degenerative process of the human meniscus. Menisci were obtained from patients with and without knee osteoarthritis (OA), and degeneration was histologically assessed using a grading system. Immunohistochemistry, real‐time polymerase chain reaction (PCR), and Western
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Pressure change at ankle joint in supramalleolar osteotomy with or without fibular osteotomy according to different types of varus ankle J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-05 Jung‐Min Lee, Sung‐Jae Lee, Chul Hyun Park
The need for additional fibular osteotomy (FO) when performing supramalleolar osteotomy (SMO) in the varus ankle arthritis (VAA) is controversial. Some cadaveric studies have been performed to prove this; however, it is difficult to implement deformities including talar tilting and translation in cadavers. In this study, we created a model of VAA with the tilting and translation using three‐dimensional
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Ex vivo storage of human osteochondral allografts: Long‐term analysis over 300 days using a Ringer‐based solution J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-05 Zhida Jiang, Jan‐Dierk Clausen, Denise Jahn, Dag Wulsten, Luisa M. Gladitz, Katrin Bundkirchen, Christian Krettek, Claudia Neunaber
Large osteochondral defects are a major challenge in orthopedics, for which osteochondral allograft (OCA) transplantation is nowadays considered as an option, especially in young patients. However, a major issue with OCA is the need for graft storage, which ensures adequate cartilage integrity over time. The aim of this study was to test how long a Ringer‐based storage solution can provide good graft
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Osseointegration of minimally invasive sacroiliac joint fixation implants—A human retrieval study J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-04 Engelke Randers, Thomas Kibsgård, Liebert P. Nogueira, Trygve Kjensjord, Stephan M. Röhrl, Lars Nordsletten, Britt Stuge
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Regenerative capacity of human pluripotent stem cell‐derived articular chondrocytes in vitro J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-04 Rosanne M. Raftery, Steven K. Pregizer, Sophia Kocher, April M. Craft
The ideal cell source for articular cartilage repair remains elusive. Using developmentally inspired differentiation protocols, we induced human pluripotent stem cells (hPSCs) toward articular chondrocytes capable of joint cartilage repair in rodent models, which were distinct from growth plate chondrocytes, fated to be replaced by bone in vivo. Working toward clinical translation, we demonstrated
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“Top 20” residency‐trained academic orthopaedic surgeons have higher academic productivity and funding in their careers J. Orthop. Res. (IF 2.8) Pub Date : 2024-03-04 Dhruv Mendiratta, Isabel Herzog, Daniel F. Liggio, David Ahn, Michael Vosbikian, Neil Kaushal, Alice Chu
“Top 20” status on Doximity, an online networking service for medical professionals, is an indicator of the reputation of a residency program. The study assesses how training at a Top 20 (T20) orthopaedic residency program impacts career productivity and funding. Fellowship and Residency Electronic Interactive Database was used in 2022 to identify active orthopaedic residency programs. Demographic
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Acceptable range of forearm deformity derived from relation to three‐dimensional analysis and clinical impairments J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-28 Ryoya Shiode, Satoshi Miyamura, Arisa Kazui, Toru Iwahashi, Hiroyuki Tanaka, Seiji Okada, Tsuyoshi Murase, Kunihiro Oka
This study aimed to investigate deformity patterns that cause clinical impairments and determine the acceptable range of deformity in the treatment of forearm diaphyseal fractures. A three‐dimensional (3D) deformity analysis based on computed bone models was performed on 39 patients with malunited diaphyseal both‐bone forearm fractures to investigate the 3D deformity patterns of the radius and ulna
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High rates of vitamin D insufficiency among patients presenting for total knee arthroplasty J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-28 Christina Liu, Thany Seyok, Stephen Moye, Lansing Sugita, Ehab Eltouny, Christopher Carrera, Prabhavi Denagamage, Julia Charles, Wolfgang Fitz, Antonia F. Chen, Brandon Earp
Widely varying prevalence of vitamin D deficiency has been reported in patients presenting for total knee arthroplasty (TKA). The primary aim of this study was to determine vitamin D levels in TKA patients and to compare to patients already routinely evaluated for vitamin D levels, patients with fragility fractures of the distal radius (DRF). There is significant overlap between patients presenting
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Computer simulation study of cementless cup placement for dysplastic hip osteoarthritis using subluxation percentage of Crowe classification J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-27 Keiji Otaka, Yusuke Osawa, Yasuhiko Takegami, Hiroki Iida, Yuto Ozawa, Hiroto Funahashi, Shiro Imagama
It is often difficult to achieve adequate bone coverage of the cup in total hip arthroplasty in cases of severe developmental dysplasia of the hip (DDH). This study aimed to evaluate the relationship between subluxation percentage of Crowe classification and cup center‐edge (cup‐CE) angle to investigate whether subluxation percentage according to the Crowe classification is a useful indicator for cementless
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The role of bone remodeling in measuring migration of custom implants for large acetabular defects J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-27 Sara De Angelis, Anna Di Laura, Angelika Ramesh, Johann Henckel, Alister Hart
In revision total hip arthroplasty, achieving robust fixation is difficult and implant movement may occur over time. Bone may also rearrange around the implant as a result of mechanical loading, making the measurement of migration challenging. The study aimed to quantify changes in bone shape and implant position 1 year following acetabular reconstruction using custom three‐dimensional‐printed cups
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Moment arm and torque generating capacity of semitendinosus following tendon harvesting for anterior cruciate ligament reconstruction: A simulation study J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-24 William du Moulin, Matthew Bourne, Laura E. Diamond, Jason Konrath, Christopher Vertullo, David J. Saxby
Altered semitendinosus (ST) morphology and distal tendon insertion following anterior cruciate ligament reconstruction (ACLR) may reduce knee flexion torque generating capacity of the hamstrings via impaired ST force generation and/or moment arm. This study used a computational musculoskeletal model to simulate mechanical consequences of tendon harvest for ACLR on ST function by modeling changes in
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Normal and malaligned talonavicular fusion alters cadaveric foot pressure and kinematics J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-24 Elizabeth P. Wahl, William D. Lin, Eric C. Whittaker, Brian K. Cook, Bruce J. Sangeorzan, William R. Ledoux
Talonavicular (TN) fusion is a common treatment for TN arthritis or deformity correction. There is incongruous evidence regarding remaining motion at the talocalcaneal and calcaneocuboid joints after TN fusion. Additionally, the effects of a malaligned TN fusion are not well understood and alignment of the fusion may be important for overall foot integrity. This project assessed the kinematic and kinetic
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Patellar tendon biomechanical and morphologic properties and their relationship to serum clinical variables in persons with prediabetes and type 2 diabetes J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-24 Shivam H. Patel, Nathan W. C. Campbell, Chinonso E. Emenim, Dominick O. Farino, Frederick W. Damen, Joseph V. Rispoli, Craig J. Goergen, Jacob M. Haus, Arman Sabbaghi, Chad C. Carroll
Tendon biomechanical properties and fibril organization are altered in patients with diabetes compared to healthy individuals, yet few biomarkers have been associated with in vivo tendon properties. We investigated the relationships between in vivo imaging‐based tendon properties, serum variables, and patient characteristics across healthy controls (n = 14, age: 45 ± 5 years, body mass index [BMI]:
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Evaluation of tendon and ligament microstructure and mechanical properties in a canine model of mucopolysaccharidosis I J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-18 Yian Khai Lau, Keerthana Iyer, Snehal Shetye, Chet S. Friday, George R. Dodge, Michael W. Hast, Margret L. Casal, Rahul Gawri, Lachlan J. Smith
Mucopolysaccharidosis (MPS) I is a lysosomal storage disorder characterized by deficient alpha-l-iduronidase activity, leading to abnormal accumulation of glycosaminoglycans (GAGs) in cells and tissues. Synovial joint disease is prevalent and significantly reduces patient quality of life. There is a strong clinical need for improved treatment approaches that specifically target joint tissues; however
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Development of patellofemoral osteoarthritis with knee joint malalignment and lateral patellar dislocation after hindlimb suspension in growing rats J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-18 Junya Ozawa, Airi Ikeda, Marina Kanehara, Hideki Moriyama, Akinori Kaneguchi
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Comparison of iliopsoas tendonitis after hip resurfacing arthroplasty and total hip arthroplasty: A case-controlled investigation using a validated simulation J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-17 Max Hardwick-Morris, Joshua Twiggs, Brad Miles, Rami M. A. Al-Dirini, Mark Taylor, Jitendra Balakumar, William L. Walter
Iliopsoas tendonitis, typically caused by impingement with the acetabular cup, occurs in up to 18% of patients after total hip arthroplasty (THA) and up to 30% of patients after hip resurfacing arthroplasty (HRA). We have developed a simulation for detecting iliopsoas impingement and validated it in a previous study of THA patients. However, due to the difference in incidence between HRA and THA, this
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A scoping review of human skeletal kinematics research using biplane radiography J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-17 Joshua C. Setliff, William J. Anderst
Biplane radiography has emerged as the gold standard for accurately measuring in vivo skeletal kinematics during physiological loading. The purpose of this scoping review was to map the extent, range, and nature of biplane radiography research on humans from 2004 through 2022. A literature search was performed using the terms biplane radiography, dual fluoroscopy, dynamic stereo X-ray, and biplane
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Impact of yoga asanas on flexion and relaxation phenomenon in women with chronic low back pain: Prophet model prospective study J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-21 Nicola Marotta, Alessandro de Sire, Lorenzo Lippi, Lucrezia Moggio, Anna Tasselli, Marco Invernizzi, Antonio Ammendolia, Teresa Iona
Chronic nonspecific low back pain (NSLBP) is a prevalent condition with socioeconomic and healthcare challenges. The flexion–relaxation phenomenon (FRP) evaluation is a valid clinical tool for low back pain (LBP) assessment. Yoga, a holistic mind–body practice, has been explored as an LBP intervention. This study aimed to evaluate the impact of yoga asanas on the FRP in women with NSLBP. The study
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Regional healing trajectory of the patellar tendon after bone‐patellar tendon‐bone autograft harvest for anterior cruciate ligament reconstruction J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-20 Naoaki Ito, Haraldur B. Sigurðsson, Daniel H. Cortes, Lynn Snyder‐Mackler, Karin Grävare Silbernagel
Graft site morbidities after bone‐patellar tendon‐bone (BPTB) autograft harvest for anterior cruciate ligament reconstruction (ACLR) negatively impacts rehabilitation. The purpose of this study was to establish tendon structural properties 1‐month after BPTB autograft harvest compared to the uninvolved patellar tendon, and subsequently to quantify the healing trajectory of the patellar tendon over
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Influence of offset on osseointegration in cementless total hip arthroplasty: A finite element study J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-20 Michel Meisterhans, Dimitris Dimitriou, Marie‐Rosa Fasser, Armando Hoch, Lukas Jud, Patrick O. Zingg
Early aseptic loosening is caused by deficient osteointegration of the femoral stem due to increased micromotions and represents a common mode of failure in uncemented total hip arthroplasty (THA). This study hypothesized that a higher femoral offset, a smaller stem size and obesity increase femoral micromotion, potentially resulting in early aseptic loosening. A finite element analysis was conducted
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Effect of robotic gait training on muscle and bone characteristics in spinal cord transected rats J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-20 Michele LeBlanc, Michael Soucy, Moustafa Moustafa‐Bayoumi, Dalziel Soto, Jeff Nessler
Osteoporosis and loss of muscle mass are secondary issues with spinal cord injury. Robotic gait training has provided evidence of increasing bone density and muscle mass, but its effect on bone strength is undetermined. The purpose of this study was to determine the effect of a 6‐week robotic locomotion training program on skeletal muscle mass and bone characteristics. Twelve female Sprague‐Dawley
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Determination of optimal component positioning in THA using 3D preoperative planning J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-13 Michael LaCour, Manh Ta, Jarrod Nachtrab, Thang Nguyen, Richard Komistek
Advancements in three-dimensional (3D) preoperative planning tools can offer surgeons and design engineers detailed feedback and additional opportunities for clinical advancements. The objective of this study is to use a 3D total hip arthroplasty preoperative planning tool to compare femoral component alignment for three different stem systems. The planning tool in this study used morphology data of
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Indirect influence of microRNA-146a on the association of IL-6 and TNF-α genetic polymorphisms with the increased risk of hip osteoarthritis J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-11 Karlo Tudor, Jurica Baranasic, Jelena Knezevic, Marta Serer Vicevic, Maja Sutic, Zlatko Dembic, Zdravko Jotanovic
Primary osteoarthritis (POA) is a complex hereditary disease that involves the interplay between genetics and epigenetics. MicroRNA molecules play important roles in epigenetic mechanisms. MicroRNA-146a (miR-146a) is a negative regulator of the immune response in osteoarthritis (OA). So, variations in the miR-146a gene could affect OA risk. The aim of this study was to investigate the relationships
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Scapular morphology variation affects reverse total shoulder arthroplasty biomechanics. A predictive simulation study using statistical and musculoskeletal shoulder models J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-11 Pavlos Silvestros, George S. Athwal, Joshua W. Giles
Reverse total shoulder arthroplasty (RTSA) accounts for over half of shoulder replacement surgeries. At present, the optimal position of RTSA components is unknown. Previous biomechanical studies have investigated the effect of construct placement to quantify mobility, stability and functionality postoperatively. While studies have provided valuable information on construct design and surgical placement
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Classification of inertial sensor-based gait patterns of orthopaedic conditions using machine learning: A pilot study J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-11 Constanze Dammeyer, Corina Nüesch, Rosa M. S. Visscher, Yong K. Kim, Petros Ismailidis, Matthias Wittauer, Karl Stoffel, Yves Acklin, Christian Egloff, Cordula Netzer, Annegret Mündermann
Elderly patients often have more than one disease that affects walking behavior. An objective tool to identify which disease is the main cause of functional limitations may aid clinical decision making. Therefore, we investigated whether gait patterns could be used to identify degenerative diseases using machine learning. Data were extracted from a clinical database that included sagittal joint angles
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Influence of sidewall retention and interference fit in total ankle replacement on implant-bone micromotion: A finite element study J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-07 Joshua E. Johnson, Gabriel A. Clarke, Cesar de Cesar Netto, Donald D. Anderson
The success of uncemented total ankle replacement (TAR) is linked to initial stability because bony ingrowth depends upon limited early micromotion. Tibial implant design fixation features resist micromotion aided by bony sidewall retention and interference fit. Our goal was to investigate factors influencing implant-bone micromotion in TAR. Two TAR tibial components were virtually inserted into CT-derived
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Deep learning based detection of osteophytes in radiographs and magnetic resonance imagings of the knee using 2D and 3D morphology J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-07 Mitra Daneshmand, Egor Panfilov, Neslihan Bayramoglu, Rami K. Korhonen, Simo Saarakkala
In this study, we investigated the discriminative capacity of knee morphology in automatic detection of osteophytes defined by the Osteoarthritis Research Society International atlas, using X-ray and magnetic resonance imaging (MRI) data. For the X-ray analysis, we developed a deep learning (DL) based model to segment femur and tibia. In case of MRIs, we utilized previously validated segmentations
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Mesenchymal stem cells enhance targeted bone growth from injectable hydrogels with BMP-2 peptides J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-07 Stacy A. Love, Kirstene A. Gultian, Umu S. Jalloh, Anna Stevens, Tae Won B. Kim, Sebastián L. Vega
Osteoporosis is the most common chronic metabolic bone disease, and the prevalence of osteoporotic fractures is rapidly increasing with the aging population. While bisphosphonates can reduce bone loss and risk of fracture, these drugs are systemic, rely on long-term use, and patient compliance is low. Recombinant human bone morphogenetic protein-2 (BMP-2) is an FDA-approved protein that can offer a
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The effect of MSM in the treatment of ankle arthrosis: Is MSM as effective as methylprednisolone or hyaluronic acid? J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-05 Koray Akpınar, Ekin K. Şimşek, Özlem Işıksaçan Özen, Bahtiyar Haberal
Posttraumatic ankle osteoarthritis (PTAO) causes severe ankle and adjacent joint morbidity. We aimed to compare the treatment efficacy of previously tried and still applied intra-articular injections and oral methylsulfonylmethane (MSM) at functional and histopathological level in PTAO animal model. Thirty-two adult female Sprague-Dawley rats were divided into four groups (Group 1: Control, Group 2:
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Comprehensive evaluation of magnetic resonance imaging sequences for signal intensity based assessment of anterior cruciate ligament healing following surgical treatment J. Orthop. Res. (IF 2.8) Pub Date : 2024-02-05 Shankar G. Kaushal, Jin-Young Kim, Mallika Singh, Mo Han, Sean W. Flannery, Dominique A. Barnes, Kirsten Ecklund, Martha M. Murray, Gary J. Badger, Braden C. Fleming, Ata M. Kiapour
Normalized signal intensity (SI) obtained from magnetic resonance imaging (MRI) has been used to track anterior cruciate ligament (ACL) postoperative remodeling. We aimed to assess the effect of MRI sequence (PD: proton density-weighted; T2: T2-weighted; CISS: constructive interference in steady state) on postoperative changes in healing ACLs/grafts. We hypothesized that CISS is better at detecting
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Distinct patterns of cytokines, chemokines, and growth factors in synovial fluid after ACL injury in comparison to osteoarthritis J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-31 Muhammad Farooq Rai, Lei Cai, Nobuaki Chinzei, Eric J. Schmidt, Omer Yousuf, Farshid Guilak, Robert H. Brophy
This study analyzed knee synovial fluid after anterior cruciate ligament (ACL) tear and in osteoarthritis (OA) to test the hypotheses that concentrations of cytokines, chemokines, and growth factors differ (a) by diagnosis and (b) after ACL tear by time from injury and presence/absence of concomitant meniscus tear. Synovial fluid samples were collected from two groups, ACL tears (with or without meniscus
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Physical exercise to promote regeneration after peripheral nerve injury in animal models: A systematic review J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-28 Bryce Fletcher, Rachel Phillips, Amanda Faust, James L. Cook, Julia A. V. Nuelle
Peripheral nerve injuries are common injuries that often have a drastic effect on patient's activities of daily living and physical function. While techniques for the surgical repair of these injuries have improved over time, rehabilitation methods following these repairs have been non-standardized and under researched. Electronic searches were conducted in Ovid/Medline and SCOPUS to identify articles
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NSAID use in orthopedic surgery: A review of current evidence and clinical practice guidelines J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-25 Patrick M. Ryan, Haydn Scherry, Ryan Pierson, Charlie Dee Wilson, Robert A. Probe
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a valuable class of medications for orthopedic surgeons and often play a pivotal role in pain control. However, there are many common stipulations resulting in avoidance of its use in the treatment of musculoskeletal disease. This review summarizes the mechanism of action of NSAIDs as well as provides an overview of commonly used NSAIDs and the differences
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Genetics may affect the risk of undergoing surgery for rhizarthrosis J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-24 Cecilie Henkel, , Christian Erikstrup, Sisse R. Ostrowski, Ole B. Pedersen, Anders Troelsen
Osteoarthritis is a prevalent and severe disease. Involvement of the trapeziometacarpal joint is common and can lead to both pain and disability. Genetics are known to affect the risk of osteoarthritis, but it remains unclear how genetics affect disease trajectories. In this study, we investigated whether the genetic associations of trapeziometacarpal osteoarthritis (rhizarthrosis) vary with the need
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Application of radiomics model based on lumbar computed tomography in diagnosis of elderly osteoporosis J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-21 Baisen Chen, Jiaming Cui, Chaochen Li, Pengjun Xu, Guanhua Xu, Jiawei Jiang, Pengfei Xue, Yuyu Sun, Zhiming Cui
A metabolic bone disease characterized by decreased bone formation and increased bone resorption is osteoporosis. It can cause pain and fracture of patients. The elderly are prone to osteoporosis and are more vulnerable to osteoporosis. In this study, radiomics are extracted from computed tomography (CT) images to screen osteoporosis in the elderly. Collect the plain scan CT images of lumbar spine
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Tendon biomechanical properties are altered by storage duration but not freeze-thaw temperatures or cycles J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-21 Carina L. Blaker, Dylan M. Ashton, Nicholas Hartnell, Christopher B. Little, Elizabeth C. Clarke
Tendon allograft and xenograft processing often involves one or more steps of freezing and thawing. As failure strength is an important graft consideration, this study aimed to evaluate effects on failure properties when varying freeze-thaw conditions. Kangaroo tendons, a potential xenograft source, were used to evaluate changes in ultimate tensile strength (UTS), failure strain and elastic modulus
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Capacity for large language model chatbots to aid in orthopedic management, research, and patient queries J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-21 Branden R. Sosa, Michelle Cung, Vincentius J. Suhardi, Kyle Morse, Andrew Thomson, He S. Yang, Sravisht Iyer, Matthew B. Greenblatt
Large language model (LLM) chatbots possess a remarkable capacity to synthesize complex information into concise, digestible summaries across a wide range of orthopedic subject matter. As LLM chatbots become widely available they will serve as a powerful, accessible resource that patients, clinicians, and researchers may reference to obtain information about orthopedic science and clinical management
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Geometric determinants of the mechanical behavior of image-based finite element models of the intervertebral disc J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-21 Ingmar Fleps, Harrah R. Newman, Dawn M. Elliott, Elise F. Morgan
The intervertebral disc is an important structure for load transfer through the spine. Its injury and degeneration have been linked to pain and spinal fractures. Disc injury and spine fractures are associated with high stresses; however, these stresses cannot be measured, necessitating the use of finite element (FE) models. These models should include the disc's complex structure, as changes in disc
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The effect of tenotomy, neurotomy, and dual injury on mouse rotator cuff muscles: Consequences for the mouse as a preclinical model J. Orthop. Res. (IF 2.8) Pub Date : 2024-01-21 Michael C. Gibbons, Morgan Silldorff, Hiroshi Okuno, Mary C. Esparza, Christopher Migdal, Seth Johnson, Simon Schenk, Samuel R. Ward
A common animal model of muscle pathology following rotator cuff tear (RCT) is a tenotomy of the supraspinatus and infraspinatus, often combined with neurotomy of the suprascapular nerve, which induces a more robust atrophy response than tenotomy alone. However, the utility of this model depends on its similarity to human muscle pathology post-RCT, both in terms of the disease phenotype and mechanisms
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The moment arms and lines of action of subscapularis after the Latarjet procedure J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-30 Aaron Fox, Lukas Ernstbrunner, Janina Henze, Richard S. Page, David C. Ackland
The Latarjet procedure is an established surgical treatment for recurrent glenohumeral joint instability with glenoid bone loss. Intraoperatively, the conjoint tendon and its attachement on the coracoid bone graft is routed through a split in subscapularis where the graft is fixed to and augments the anteroinferior glenoid. The objective of this in vitro study was to quantify the influence of glenohumeral
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Cellular behavior and extracellular matrix turnover in bovine annulus fibrosus cells under hydrostatic pressure and deviatoric strain J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-28 Ryo Taiji, James D. Kang, Shuichi Mizuno
Intervertebral disc herniation is a common spinal disorder that is often treated with discectomy when conservative measures fail. To devise therapeutic strategies for tears in the annulus fibrosus (AF), the regenerative capability of AF cells under spinal loading needs to be addressed. We hypothesized that the compressive loading associated with deformation in AF cells reduces synthetic and degradative
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Exosomal circFAM63Bsuppresses bone regeneration of postmenopausal osteoporosis via regulating miR-578/HMGA2 axis J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-27 Feng Li, Xiaodong Zhao, Yang Zhang, Qingshan Zhuang, Song Wang, Xichi Fang, Tao Xu, Xiaopeng Li, Gaoyang Chen
Postmenopausal osteoporosis (PMOP) affects hundreds of millions of elderly women worldwide. The imbalance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption is the key factor in the progression of PMOP. Recently, exosomal circular RNAs have been considered as critical regulators in physiological and pathological progress. However, their roles in PMOP still require further
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Combining PTH(1-34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-27 Bryant C. Roberts, Vee San Cheong, Sara Oliviero, Hector M. Arredondo Carrera, Ning Wang, Alison Gartland, Enrico Dall'Ara
Combined treatment with PTH(1-34) and mechanical loading confers increased structural benefits to bone than monotherapies. However, it remains unclear how this longitudinal adaptation affects the bone mechanics. This study quantified the individual and combined longitudinal effects of PTH(1-34) and mechanical loading on the bone stiffness and strength evaluated in vivo with validated micro-finite element
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Impact of preoperative clinical state on 2-year clinical outcomes following degenerative lumbar scoliosis surgery J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-27 Lei Yuan, Yinhao Liu, Yan Zeng, Zhongqiang Chen, Weishi Li
To assess the preoperative clinical state's impact on clinical outcomes after surgery for degenerative lumbar scoliosis (DLS) based on the minimal clinically important difference (MCID). Preoperative and follow-up (FU) scores in each Scoliosis Research Society-22 (SRS-22) domain were compared with age- and sex-matched normative references. At baseline, patients were classified by differences from normative
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Correction to “Clinical and biological significance of PIM1 kinase in osteosarcoma” J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-25
Liao Y, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. J Orthop Res. 2016 Jul;34(7):1185-94. We noticed there was an error in Figure 3A of this paper was inadvertently duplicated with image of our previous publication Figure 5A of paper J Orthop Res. 2015 Feb;33(2):199-207. We have found original images of these studies and have corrected this mistake. The correct Figure
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The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-25 Noreen J. Hickok, Bingyun Li, Ebru Oral, Sebastian A. J. Zaat, David A. Armbruster, Gerald J. Atkins, Antonia F. Chen, Débora C. Coraça-Huber, Tianhong Dai, Edward M. Greenfield, Rajendra Kasinath, Matthew Libera, Cláudia N. H. Marques, T. Fintan Moriarty, K. Scott Phillips, Kapil Raghuraman, Dacheng Ren, Lia Rimondini, Kordo Saeed, Thomas P. Schaer, Edward M. Schwarz, Christopher Spiegel, Paul Stoodley
Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy
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Does cryotherapy decrease the local recurrence rate in the treatment of an aneurysmal bone cyst? A comparative assessment J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-25 Eran Levanon, Omri Merose, Ortal Segal, Solomon Dadia, Amir Sternheim, Dror Levin, Osnat Sher, Yair Gortzak
Curettage with or without the use of adjuvants is the standard of care in the treatment of an aneurysmal bone cyst (ABC). Historically, our approach combined curettage, high-speed burr drilling, and cryoablation. However, treatments varied based on age, tumor location, and surgeon preference. We asked: (1) Does cryoablation in addition to curettage and burr drilling decrease the local recurrence rates
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Embracing ethical research: Implementing the 3R principles into fracture healing research for sustainable scientific progress J. Orthop. Res. (IF 2.8) Pub Date : 2023-12-20 Amritha Anup, Sandra Dieterich, Richard O. C. Oreffo, Hannah L. Dailey, Annemarie Lang, Melanie Haffner-Luntzer, Katherine R. Hixon
As scientific advancements continue to reshape the world, it becomes increasingly crucial to uphold ethical standards and minimize the potentially adverse impact of research activities. In this context, the implementation of the 3R principles—Replacement, Reduction, and Refinement—has emerged as a prominent framework for promoting ethical research practices in the use of animals. This article aims