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Pattern, treatment modalities and radiological outcome of pediatric femoral shaft fractures; fractures treated in Northern, Tanzania medRxiv. Orthop. Pub Date : 2024-03-09 Shindo I Kilawa, Anthony J Pallangyo, Elifuraha G Maya, Rogers J Temu, Faiton N Mandari, Frank I Olotu, Estomick K Ofunguo, Adnan M Sadiq, Honest H Massawe, Octavian Shirima, Reginald Shoo
Background: Femoral shaft fracture is among the most common causes of paediatric hospitalisation, mortality and morbidity worldwide. There is no clear option that is preferable to other treatment modalities, especially between 5 to 16 years and published studies are scarce on radiological outcomes in Sub-Saharan Africa.This study aimed to determine the pattern, treatment modalities and radiological
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Specific pelvic shape in patients with developmental dysplasia of the hip on 3D morphometric homologous model analysis medRxiv. Orthop. Pub Date : 2024-03-09 Yui Sasaki, Daisuke Suzuki, Ryo Tokita, Hiroyuki Takashima, Hirofumi Matsumura, Satoshi Nagoya
Purpose: To clarify the morphological factors of the pelvis in patients with developmental dysplasia of the hip (DDH), three-dimensional (3D) pelvic morphology was analyzed using a template-fitting technique. Methods: Three-dimensional pelvic data of 50 patients with DDH (DDH group) and 3D pelvic data of 50 patients without obvious pelvic deformity (Normal group) were used. All patients were female
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A multi-center investigation on the effect of decompressive surgery on Balance and physical ActiviTy Levels in patients with lumbar Spinal stenosis (B-ATLAS): Protocol for a prospective cohort study. medRxiv. Orthop. Pub Date : 2024-02-21 Oliver Bremerskov Zielinski, Dennis Winge Hallager, Kasper Yde Jensen, Leah Y Carreon, Mikkel Osterheden Andersen, Louise P Diederichsen, Rune D Bech
Background: Patients with lumbar spinal stenosis may complain of poor balance, decreased physical function and problems maintaining physical activity levels due to radiculopathy. Decompressive surgery is often indicated if conservative management fails to achieve a satisfactory clinical outcome. While surgical management has proven effective at treating radiculopathy, and patients report increased
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Rectus Femoris Electromyography Signal Clustering: Data-Driven Management of Crouch Gait in Patients with Cerebral Palsy medRxiv. Orthop. Pub Date : 2024-02-09 Mehrdad Davoudi, Firooz Salami, Robert Reisig, Dimitrios Patikas, Sebastian Wolf
This study aimed to investigate how electromyography (EMG) cluster analysis of the rectus femoris (RF) could help to better interpret gait analysis in patients with cerebral palsy (CP). The retrospective gait data of CP patients were categorized into two groups: initial examination (E1, 881 patients) and subsequent examination (E2, 377 patients). Envelope-formatted EMG data of RF were collected. Using
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Modified FRAX Score for Prediction of Fall-induced Hip Fractures; The Added Value of Fall Energy, Number, and Social Vulnerability Index medRxiv. Orthop. Pub Date : 2024-01-28 Atta Taseh, Evan Sirls, George Casey, Sarah Hearns, Job N Doornberg, Santiago A Lozano-Calderon, Mitchel B Harris, Soheil Ashkani-Esfahani
Background: The Fracture Risk Assessment Tool (FRAX), widely used for predicting the 10-year likelihood of hip fractures, does not incorporate factors like prior falls and sociodemographic characteristics, notably the Social Vulnerability Index (SVI). Recognizing these limitations, we aim to evaluate the predictive accuracy of FRAX by integrating fall frequency, fall energy, and SVI into the model
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Study report CAMOPED study medRxiv. Orthop. Pub Date : 2024-01-25 A. Schraplau, W. Petersen, M. Herbort, B. Lischke, J. Höher, R. Becker, N. Streich, U. Stöckle, C. Schmidt-Lucke
The following report was prepared as part of a trial guideline in accordance with Section 137e (1) SGB V to evaluate the benefits of the use of CAM splints for self-application by patients in the post-surgical rehabilitative treatment of ruptures of the anterior cruciate ligament.
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Musculoskeletal Pathologies Affecting Shoulder Girdle: A Systematic Review with Anatomical and Radiological Validation medRxiv. Orthop. Pub Date : 2024-01-23 Sundip Charmode, Sudhir Shyam Kushwaha, Abhishek Kumar Mishra, Nirav Nimavat, Lalit Ratanpara, Simmi Mehra, Satish Kumar Ravi
Introduction: Musculoskeletal pathologies affecting shoulder girdle joints, other than gleno-humeral joints such as acromioclavicular joint arthritis, tendonitis, subacromial bursitis, subdeltoid bursitis, and osteochondritis dissecans, are relatively rare. In the Middle East and Asian countries, public health services are generally availed by a large number of patients in primary health centers, rural
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Cardiovascular disease and Osteoporosis : A Mendelian randomization study medRxiv. Orthop. Pub Date : 2024-01-10 ZHAO WANG, Shuyi Zhang, Hongyang Gong, Guoxu Zhao, Hong Xiao, Shuai Yuan, Wenhao Wu, Pai Xu, Yihong Chen, Yihong Chen, Mei Yang, Chan Kang
Background: Cardiovascular disease (CVD) may have some association with osteoporosis (OP). This Mendelian randomization (MR) investigation aimed to explore the potential causal linkage between CVD and OP. Methods: Utilizing genome wide association study data from individuals of European descent, we pinpointed Single Nucleotide Polymorphisms (SNPs) relevant to CVD, including those for coronary heart
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Trends in types of revision for prosthetic joint infection and risk of a second revision from 1995 to 2022: A descriptive cohort study from the Danish Hip Arthroplasty Registry medRxiv. Orthop. Pub Date : 2024-01-04 Daniel Lundsgaard, Armita Armina Abedi, Søren Overgaard, Jens Holm Laigaard
This protocol outlines a register-based cohort study utilizing Danish Hip Arthroplasty Register data from 1995 to 2022. Focusing on adult patients undergoing primary total hip arthroplasty (THA), the study categorizes revisions, particularly periprosthetic joint infections (PJI), into Debridement, antibiotics, and implant retention (DAIR), one-stage, and two-stage approaches. Annual revision numbers
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Closing the gap towards a successful referral system. A case study of a tertiary teaching and referral hospital, Kenya: pre-posttest study design medRxiv. Orthop. Pub Date : 2024-01-03 Maxwell Philip Omondi
Inappropriate utilization of higher-level health facilities and ineffective management of the referral processes in resource-limited settings is increasingly becoming a concern in health care management in developing countries. This is characterized by self-referrals and frequent bypassing of nearest health facilities. On 1st July 2021, Kenyatta National Hospital (KNH) did enforce the national referral
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A Novel Fluorescent Immuno-Lectin Assay to Identify Osteoarthritis Associated Glycoforms of Lubricin medRxiv. Orthop. Pub Date : 2024-01-03 Ali Reza Afshari, Kristina A. Thomsson, Jennifer Höglund, Henrik Ryberg, Kamlesh Gidwani, Kim Pettersson, Ola Rolfson, Lena I Björkman, Thomas Eisler, Tannin A. Schmidt, Gregory D. Jay, Niclas G. Karlsson
Lubricin or proteoglycan-4 (PRG-4) is a mucinous glycoprotein lubricating the cartilage and maintaining normal tissue function and cell-homeostasis. Altered O-glycoforms of lubricin has been found in osteoarthritis (OA) synovial fluid (SF). Here, we utilized a Fluorescent Immuno-Lectin Assay (FILA) to measure the levels of lubricin glycoforms in plasma/SF and their potential as biomarkers for disease
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Causal association of the brain structure with the risk of knee osteoarthritis: A large-scale genetic correlation study medRxiv. Orthop. Pub Date : 2023-12-30 Zhe Ruan, Shaohai Lin, Zhi Liu, Peng Chen, Tongtong Xie, Li Meng, Haitao Long, Shushan Zhao
Objectives Observational studies have shown the association between knee osteoarthritis (KOA) and neurological disorders with alterations in brain imaging-derived phenotypes (BIDPs). This study aimed at investigating whether alterations in brain structure are correlated with the occurrence of KOA.
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A New Advanced Osteoarthritis Treatment Utilizing Modified Mesenchymal Stem Cells: Arthroscopic Guided Intra-Articular Intervention Approach a Systematic Review and Meta-Analysis medRxiv. Orthop. Pub Date : 2023-12-21 Kevin Christian Tjandra, Robin Novriansyah, I Nyoman Sebastian Sudiasa, Ardiyana Ar, Nurul Azizah Dian Rahmawati, Ismail Hadisoebroto Dilogo
Background Mesenchymal stem cells (MSCs) can help repair damaged cartilage in osteoarthritis (OA) and prevent disability. Combining MSCs with platelet-rich plasma (PRP) and hyaluronic acid (HA) might make this treatment more effective. This study aims to find out how well MSCs, PRP, and different HA doses work together, what's the best source of MSCs, and how many MSCs to use for treating osteoarthritis
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Patterns of sacral dysmorphism in pelvic CT scans at a national referral hospital in Kenya medRxiv. Orthop. Pub Date : 2023-12-21 Valentine B Nyang’au, Fred Sitati, Edward Gakuya, Oline Amunga
Background Sacral dysmorphism refers to morphological variations found in the first two sacral segments that limit the safe placement of percutaneous sacral iliac screws. The prevalence is documented in European, North American and some Asian populations. However, studies within the African population including Kenya are lacking. The aim of the study was to describe the patterns of sacral dysmorphism
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Disease progression and clinical outcomes in latent osteoarthritis phenotypes: Data from the Osteoarthritis Initiative medRxiv. Orthop. Pub Date : 2023-12-15 Zeyu Huang, Mary A. Bucklin, Weihua Guo, John T. Martin
The prevalence of knee osteoarthritis (OA) is widespread and the heterogeneous patient factors and clinical symptoms in OA patients impede developing personalized treatments for OA patients. In this study, we used unsupervised and supervised machine learning to organize the heterogeneity in knee OA patients and predict disease progression in individuals from the Osteoarthritis Initiative (OAI) dataset
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Optimal and Safe Pain Management Approach in Ankle and Hindfoot Fractures: Improving Practitioner Decision medRxiv. Orthop. Pub Date : 2023-12-09 Tashfeen Ahmad, Zehra Abdul Muhammad, Yasir Mohib, Riaz Hussain, Masood Umer
Background Over or sub-optimal analgesic treatment leads to undesired consequences and patient dissatisfaction. The study aims to assess the sub-optimal or optimal pain relief and safety of routinely prescribed oral analgesic(s) at discharge and 1-week post-discharge in ankle and foot fracture surgeries.
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Buried or Exposed Kirschner Wire for the Management of Hand and Forearm Fractures: A Systematic Review, Meta-Analysis, and Meta-Regression medRxiv. Orthop. Pub Date : 2023-12-09 Nucki Nursjamsi Hidajat, RM. Satrio Nugroho Magetsari, Gregorius Thomas Prasetiyo, Danendra Rakha Putra Respati, Kevin Christian Tjandra
Background The recommendation on whether to bury or expose the Kirschner wire (K-wire) for the management of fractures has still been controversial with inconsistent results in the published studies. This study aims to summarize the comparison between buried and exposed K-wire for the management of hand and forearm fractures.
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Correlation of Social Determinants of Health and Chronic Nonspecific Low Back Pain; A Brief Report medRxiv. Orthop. Pub Date : 2023-12-09 Alireza Ebrahimi, Hyunjoon Rhee, Atta Taseh, Hye Chang Rhim, Soheil Ashkani-Esfahani
Background Low back pain (LBP) ranks as one of the top contributors to disability-adjusted life years worldwide. Social determinants of health (SDoH) encompass a range of factors that play a pivotal role in shaping healthcare outcomes. We aimed to examine the differences in SDoH between patients with acute and chronic non-specific low back pain (NSLBP).
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Item generation for a new patient-reported outcome measure: The non-traumatic anterior knee pain (AKP)-YOUTH scale medRxiv. Orthop. Pub Date : 2023-12-07 Marie Germund Nielsen, Kristian Damgaard Lyng, Sinead Holden, Simon Kristoffer Johansen, Marinus Winters, Michael Skovdal Rathleff
Question: Which domains are important to develop a preliminary item bank for a new patient-reported outcome measure relating to adolescents with non-traumatic anterior knee pain? Design: Multiple methods: semi-structured interviews, Participants: Twenty-one adolescents with anterior knee pain participated in semi-structured interviews which explored their experience of living with knee pain. Following
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Action observation intervention using three - dimensional movies improves the usability of hands with distal radius fractures in daily life: a nonrandomized controlled trial in women medRxiv. Orthop. Pub Date : 2023-11-20 Kengo Usuki, Hiroaki Ueda, Toshiya Yamaguchi, Takako Suzuki, Toyohiro Hamaguchi
Prolonged immobilization of joints after distal radius fracture (DRF) leads to cerebral disuse-dependent plasticity (DDP) and deterioration of upper extremity function. Action observation therapy (AOT) can improve DDP. This nonrandomized controlled trial (UMIN 000039973) tested the hypothesis that AOT improves hand-use difficulties during activities of daily living in patients with DRF. Right-handed
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The potential effect of romosozumab on perioperative management for instrumentation surgery medRxiv. Orthop. Pub Date : 2023-11-11 Koji Ishikawa, Soji Tani, Tomoaki Toyone, Koutaro Tsuchiya, Tomoko Towatari, Yusuke Oshita, Ryo Yamamura, Takashi Nagai, Toshiyuki Shirahata, Katsunori Inagaki, Yoshifumi Kudo
Background: Age-related changes in bone health increase the risk for complications in elderly patients undergoing orthopedic surgery. Osteoporosis is a key therapeutic target that needs to be addressed to ensure successful instrumentation surgery. The effectiveness of pharmacological interventions in orthopedic surgery, particularly the new drug romosozumab, is still unknown. We aim to evaluate the
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A Genome-Wide Association Study (GWAS) meta-analysis of post-traumatic osteoarthritis of the knee (GO-PTOA): Protocol for Analysis Plan medRxiv. Orthop. Pub Date : 2023-11-06 Merry-Lynn McDonald, Joshua S. Richman, Cindy Boer, Raneem Kalsoum, Daniel Dochtermann, Tyler Barker, Kristin Briem, Konstantinos Hatzikotoulas, Benjamin Hollis, Luke Jostins-Dean, Reedik Magi, Ene Reimann, EstBB Research Team, Lorraine Southam, Unnur Styrkarsdottir, Hemant Tiwari, Joyce BJ van Meurs, Eleftheria Zeggini, Jasvinder Singh, Fiona E Watt
Post Traumatic Osteoarthritis (PTOA) of the knee is osteoarthritis (OA) occurring specifically after a significant acute injury to the joint. Approximately 50% of people with significant knee joint injuries, such as anterior cruciate ligament (ACL) rupture, develop symptomatic radiographic OA within 10 years. Although impacts of the disease are well-described, there is little known about the genetic
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Demonstrating the Utility of Instrumented Gait Analysis in the Treatment of Children with Cerebral Palsy medRxiv. Orthop. Pub Date : 2023-11-02 Michael H Schwartz, Andrew J. Ries, Andrew G. Georgiadis, Hans Kainz
Background: Instrumented gait analysis (IGA) has been around for a long time but has never been shown to be useful for improving patient outcomes. In this study we demonstrate the potential utility of IGA by showing that machine learning models are better able to estimate treatment outcomes when they include both IGA and clinical (CLI) features compared to when they include CLI features alone. Design:
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WITHDRAWN: Classification and Treatment of Tibial Tubercle Fractures in Adults medRxiv. Orthop. Pub Date : 2023-10-31 Xiang Yao, Hongyuan Liu, Minjie Hu, Chong Wang, Han Miao, Jilei Tang
The authors have withdrawn their manuscript owing to 1. The paper needs structural changes. 2. Some of the data were found to have errors that need to be corrected after the previous submission. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
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Effect of high-dose glucocorticoids on persistent opioid use 3 to 12 months after primary total hip or knee arthroplasty. Protocol for a target trial emulation using observational data from Danish registries medRxiv. Orthop. Pub Date : 2023-10-31 Jens Laigaard, Robin Christensen, Claus Varnum, Martin Lindberg-Larsen, Troels Haxholdt Lunn, Ole Mathiesen, Soeren Overgaard
Background: Persistent postsurgical pain and opioid use after primary total hip and knee arthroplasty (THA and TKA) have major consequences for the patient and for society. High-dose perioperative treatment with glucocorticoids reduces inflammation and acute pain, both of which are associated with persistent postsurgical pain. We therefore hypothesise that routine treatment with glucocorticoids reduces
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Regular Non-steroidal Anti-inflammatory Drug Use Increases Stress Fracture Risk in the General Population: A Retrospective Case-Control Study medRxiv. Orthop. Pub Date : 2023-10-31 Alexandra Ciuciu, Christopher Mulholland, Michael A Bozzi, Chris C Frymoyer, Leonardo Cavinatto, David Yaron, Marc I Harwood, Jeremy D Close, Christopher J Mehallo, Ryan E Tomlinson
Previous studies have shown that the use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with increased stress fracture risk, potentially due to diminished skeletal adaptation. This phenomenon has been studied predominantly in high-activity individuals like dancers, athletes, and soldiers, so current data regarding the general population is limited despite the substantial economic and
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PCBP2 as an intrinsic aging factor regulates the senescence of hBMSCs through the ROS-FGF2 signaling axis medRxiv. Orthop. Pub Date : 2023-10-14 Pengbo Chen, Bo Li, Zeyu Lu, Qingyin Xu, Huoliang Zheng, Shengdan Jiang, Leisheng Jiang, Xinfeng Zheng
Background: It has been reported that loss of PCBP2 led to increased reactive oxygen species (ROS) production and accelerated cell aging. Knockdown of PCBP2 in HCT116 cells leads to significant down-regulation of fibroblast growth factor 2 (FGF2). Here, we tried to elucidate the intrinsic factors and potential mechanisms of BMSCs aging from the interactions among PCBP2, ROS and FGF2.
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Research Protocol for a Randomised Controlled Trial Comparing the Outcome of the 3D-Printed Patient-Specific-Instrument Assisted Lapidus Fusion vs Conventional Lapidus Fusion for Surgical Correction of Hallux Valgus Deformity medRxiv. Orthop. Pub Date : 2023-10-05 Samuel Ka-Kin Ling, Rachel Xiaoyu Wei, Elvis Chun-Sing Chui, Boon Hor Chong, Michael Tim-Yun Ong, Pauline Po-Yee Lui, Patrick Shu-Hang Yung
Introduction Hallux valgus (HV) affects up to 30% of the population. Lapidus surgery with 1st tarsal-metatarsal joint arthrodesis is one of the most common surgical options for HV. Despite its popularity, the current procedure is not without complications. This investigation will be the world’s first Lapidus arthrodesis surgery utilising patient-specific instruments (PSI) as an assistive tool. We hypothesise
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Individuals with knee osteoarthritis show few limitations in reactive stepping responses after gait perturbations medRxiv. Orthop. Pub Date : 2023-10-05 Ramon J. Boekesteijn, Noel L.W. Keijsers, Koen Defoort, Alexander C.H. Geurts, Katrijn Smulders
Background: Knee osteoarthritis (OA) causes structural joint damage. The resultant symptoms can impair the ability to recover from unexpected gait perturbations, contributing to an increased fall risk. This study compared reactive stepping responses to gait perturbations between individuals with knee OA and healthy individuals. Methods: Kinematic data of 35 individuals with end-stage knee OA, and 32
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Deep learning-Based Correlation Analysis of Pelvic and Spinal Sequences for Enhanced Sagittal Spinal Alignment Prediction medRxiv. Orthop. Pub Date : 2023-09-17 Kai Song, Huan Qi, Chi Ma, Fei Peng Chi, Yu Jun Lin, Qiang Yang, Cao Yang, Bing Wang, Cai Fang Li, Zhang Ze Zhu, Shi Wei Li, Guo Jian Zhang, William Lu, Zheng Wang
Background: Pelvic Incidence (PI) plays a crucial role in surgical planning. However, it is insufficient for accurately predicting spinal alignment parameters, including Sacral Slope, Pelvic Tilt, and Lumbar Lordosis. We have devised an AI-based method for predicting sagittal spinal alignments with enhanced precision. Methods: We have developed an AI-based system utilizing a Seq2Seq framework to model
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Real-world gait and turning in individuals scheduled for total knee arthroplasty medRxiv. Orthop. Pub Date : 2023-09-13 Ramon J. Boekesteijn, Noel L.W. Keijsers, Koen Defoort, Martina Mancini, Frank J. Bruning, Mahmoud El-Gohary, Alexander C.H. Geurts, Katrijn Smulders
Objective: To compare real-world gait and turning between individuals scheduled for total knee arthroplasty (TKA) and healthy controls, using continuous monitoring with inertial measurement units (IMUs). Design: Real-world gait and turning data were collected for 5-7 days in individuals scheduled for TKA (n=34) and healthy controls in the same age range (n=32) using IMUs on the feet and lower back
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Multidimensional analysis of preoperative patient-reported outcome measures identifies distinct phenotypes in patients booked for total knee arthroplasty: Secondary analysis of the SHARKS registry in a metropolitan hospital department medRxiv. Orthop. Pub Date : 2023-09-04 Raquel McGill, Corey Scholes, Stephen Torbey, Lorezno Calabro
Aims Traditional research on total knee arthroplasty (TKA) has predominantly utilised individual preoperative patient-reported outcome measures (PROMs) to predict postoperative satisfaction. The objective of this study was to leverage the power of machine learning to simultaneously analyse multiple PROMs, thus unveiling unique patient phenotypes within this heterogeneous population. This study aimed
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Defining the extracellular matrix in non-cartilage soft tissues in osteoarthritis - a systematic review medRxiv. Orthop. Pub Date : 2023-08-31 Jolet Y Mimpen, Iwan Raza, Sarah Snelling
Objective Osteoarthritis (OA) is increasingly seen as a disease of global joint dysfunction, affecting not only cartilage but also the other joint tissues. Extracellular matrix (ECM) is a critical determinant of tissue mechanobiology, but ECM is poorly understood in osteoarthritic joint tissues beyond cartilage in human OA and animal models of OA. Therefore, we aimed to define the structural composition
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Clinical investigations to evaluate high-risk orthopaedic devices: systematic review of the peer-reviewed medical literature medRxiv. Orthop. Pub Date : 2023-08-24 Anne Lubbeke, Christophe Combescure, Christophe Barea, Amanda Inez Gonzalez, Keith Tucker, Per Kjaersgaard-Andersen, Tom Melvin, Alan G Fraser, Rob Nelissen, James Andrew Smith
Purpose: The objective of this systematic review was to give an overview of clinical investigations regarding hip and knee arthroplasty implants published in peer-reviewed scientific medical journals before entry into force of the EU Medical Device Regulation in May 2021. Methods: We systematically reviewed the medical literature for a random selection of hip and knee implants, to identify all peer-reviewed
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A Novel Model of Sacral Obliquity, Iliac Obliquity, and Hip Obliquity in Adolescent Idiopathic Scoliosis medRxiv. Orthop. Pub Date : 2023-08-15 Pengfei Chi, Junyao Cheng, Kai Song, Bing Wu, Wen Yu, Yang Yu, Geng Cui, Zheng Wang
Objective: To propose and validate a novel model to explore the potential compensatory mechanism of sacral obliquity and pelvic obliquity in coronal balance. Summary of Background Data: Sacral obliquity and pelvic obliquity are common phenomena in adolescent idiopathic scoliosis (AIS). However, their compensatory mechanisms in coronal balance remain unclear. Methods: A total of 569 AIS patients were
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Assessing the performance of GPT-4 in the filed of osteoarthritis and orthopaedic case consultation medRxiv. Orthop. Pub Date : 2023-08-09 juntan li, Xiang Gao, Tianxu Dou, Yuyang Gao, Wannan Zhu
Background: Large Language Models (LLMs) like GPT-4 demonstrate potential applications in diverse areas, including healthcare and patient education. This study evaluates GPT-4's competency against osteoarthritis (OA) treatment guidelines from the United States and China and assesses its ability in diagnosing and treating orthopedic diseases. Methods: Data sources included OA management guidelines and
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Factors affecting social integration after road traffic orthopaedic injuries in Rwanda medRxiv. Orthop. Pub Date : 2023-08-07 JC ALLEN INGABIRE, Stewart Aimee, Gerard Urimubenshi, David K. Tumusiime, Carine Uwakunda, Didace Mugisha, Georges Bucyibaruta
Background: Road traffic injuries (RTIs) leading to long-term disability present a significant public health challenge, causing immense personal and societal consequences. However, in many developing countries, information on the social integration of patients post-RTI remains limited. Purpose: This study aimed to identify factors contributing to social integration following road traffic-related orthopedic
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Clustering of Shoulder Movement Patterns using K-means Algorithm Based on the Shoulder Range of Motion medRxiv. Orthop. Pub Date : 2023-08-05 Jun-hee Kim
Background: Categorization in medicine is used to enhance understanding of a disease or syndrome and apply it to treatment and is based on human clinical experience or theory. Cluster analysis using the K-means algorithm is an unsupervised machine learning method that classifies clusters based on numerical data Purpose: The purpose of this study was to classify subjects into clusters using K-means
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Do we need to reconsider knee valgus as a sole risk factor for second ACL injury? Exploratory analysis of individual Landing Error Scoring System (LESS) items with three year follow-up medRxiv. Orthop. Pub Date : 2023-08-04 Nicky van Melick, Lisa van Rijn, Rob Bogie, Thomas J. Hoogeboom
Background: It remains unclear which movement quality items are associated with second anterior cruciate ligament (ACL) injuries after ACL reconstruction. Hypotheses: 1) Movement quality measured with the Landing Error Scoring System (LESS) is not associated with second ACL injury in soccer players who returned to sports after ACL reconstruction. 2) In an exploratory analysis, soccer players with and
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Effects of age and sex on patient-reported outcomes following total knee arthroplasty with a rotating bearing tibial platform design: A single-surgeon practice registry study medRxiv. Orthop. Pub Date : 2023-08-01 Manaal Fatima, Corey Scholes, John Ireland
The authors have withdrawn their manuscript owing to a manufacturer's recall notice for the implant reported. The results reported here may have been impacted by a higher than expected rate of implant revision, which cannot be verified in the available data. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding
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A Multi-layer Perceptron Neural Network for Predicting the Osteoporosis in Women Using Physical Activity Factors medRxiv. Orthop. Pub Date : 2023-07-31 Jun-hee Kim
Background: Osteoporosis (OP) is a bone disease caused by a decrease in bone mineral density (BMD). OP is common in women because BMD gradually decreases after age 35. OP due to decreased BMD is highly likely to cause fatal traumatic injuries such as hip fracture. Purpose: To develop and evaluate a multi-layer perceptron neural network model that predicts OP using physical characteristics and activity
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Machine Learning Classifier Models for Predicting Sarcopenia in the Elderly Based on Physical Factors medRxiv. Orthop. Pub Date : 2023-07-31 Jun-hee Kim
Background: As the elderly population gradually increases, musculoskeletal disorders such as sarcopenia are increasing. Diagnostic techniques such as X-ray, CT, and MRI imaging are used to predict and diagnose sarcopenia, and methods using machine learning are gradually increasing. Purpose: The purpose of this study was to create a model that can predict sarcopenia using physical characteristics and
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Beta-blocker exposure is associated with nonunion in a geriatric cohort of 253,266 fractures medRxiv. Orthop. Pub Date : 2023-07-16 Lillia Steffenson, Brook Martin, Adam Kantor, Dillon O'Neill, Luke Myhre, Tyler Thorne, David Rothberg, Thomas Higgins, Justin Haller, Lucas Marchand
Previously published animal studies have shown positive skeletal effects with local or systemic administration of beta blockers (BBs). However, population studies have shown mixed effects on bone mineral density (BMD) and fracture risk with BB use. The goal of this study was to evaluate whether exposure to BB is associated with fracture nonunion. Fee-for-service Medicare beneficiaries with an extremity
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CT validation of intraoperative imageless navigation (Naviswiss) for component positioning accuracy in primary total hip arthroplasty in supine patient position: A prospective observational cohort study in a single-surgeon practice medRxiv. Orthop. Pub Date : 2023-07-12 Corey Scholes, John Ireland, Tobias Schwaegli
The aim of this study was to report on the validity of the Naviswiss handheld image-free navigation device for accurate measurement of THA component positioning intraoperatively, in comparison with the three-dimensional (3D) reconstruction of computed tomography (CT) images as gold standard. Methods: A series of patients presenting to a single-surgeon clinic with end-stage hip osteoarthritis received
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A Study of Patients undergoing Trigger Finger Release Surgery in a Primary Care setting: Organisational Capabilities, Outcomes and Benefits medRxiv. Orthop. Pub Date : 2023-07-03 Fahad Rizvi, Ryan Rong Wei Chen, Ethan Amos Kong, Joshua Pui Chun Wong, Neal Khambhayata, Dhriti Arya, Tariq Kapasi, Philippe B Wilson
Background Trigger finger is a common hand condition in which a finger is unable to fully extend due to a thickening of the tendon and its sheath, causing the finger to lock in a bent position. Aim To assess the viability of carrying out Trigger Finger surgeries in NHS primary care in terms of clinician and patient acceptance, experience and outcomes, and operational requirements of this service for
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Fusion of Electronic Health Records and Radiographic Images for a Multimodal Deep Learning Prediction Model of Atypical Femur Fractures medRxiv. Orthop. Pub Date : 2023-07-03 Jorg Schilcher, Alva Nilsson, Oliver Andlid, Anders Eklund
Atypical femur fractures (AFF) represent a very rare type of fracture that can be difficult to discriminate radiologically from normal femur fractures (NFF). AFFs are associated with drugs that are administered to prevent osteoporosis-related fragility fractures, which are highly prevalent in the elderly population. Given that these fractures are rare and the radiologic changes are subtle currently
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The protein profiles of postoperative incision infection after plate internal fixation of calcaneal fractures medRxiv. Orthop. Pub Date : 2023-06-28 Jun Wen, Zhong Wen
Abstract: Background: Nowadays, the internal fixation has been an effective way for calcaneal fractures treatment. However, high risk of infection was found after the internal fixation, and the mechnism remains unclear. Objective: In this work, we systematically preformed a comparative proteomic analysis between necrotic tissues and normal soft tissues aiming to find the molecular changes of the tissue
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Benign Bone Lesions: Do They Warrant Follow-Up? medRxiv. Orthop. Pub Date : 2023-06-27 Andrew Brook, Harrison Volaski, Emily Kleinbart, Jichuan Wang, Swapnil Singh, Rui Yang, Bang Hoang, Waleed Al-Hardan, Ranxin Zhang, Beverly Thornhill, David S. Geller
Background: There are no established surveillance guidelines for benign bone lesions, particularly for those that do not merit surgery. It is unclear how long or how often patients should be followed, what type of radiographic studies should be obtained, and how frequency repeat imaging should be performed. Given that follow-up incurs cost, time, and resources, it is essential to better understand
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Imageless navigation system (Naviswiss) provides acceptable accuracy with magnitude-dependent bias in component position in total hip arthroplasty for end-stage hip osteoarthritis: A prospective cohort study with CT-validation medRxiv. Orthop. Pub Date : 2023-06-08 Corey Scholes, Manaal Fatima, Tobias Schwagli, David Liu
Aims: The Naviswiss system (Naviswiss AG, Brugg, Switzerland) is a handheld imageless navigation device used to improve the accuracy of implant positioning in total hip arthroplasty (THA). However, clinical data for leg length discrepancy and femoral offset is lacking, and the validity of the system has not been reported for patients undergoing THA in the lateral decubitus position. This study aimed
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POST-COVID ORTHOPAEDIC ELECTIVE RESOURCE PLANNING USING SIMULATION MODELLING medRxiv. Orthop. Pub Date : 2023-06-05 Alison Harper, Thomas Monks, Rebecca Wilson, Maria Theresa Redaniel, Emily Eyles, Tim Jones, Chris Penfold, Andrew Elliott, Tim Keen, Martin Pitt, Ashley Blom, Michael Whitehouse, Andrew Judge
Objectives To develop a simulation model to support orthopaedic elective capacity planning.
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Validity of observation tools for patients hospitalized with osteoporotic vertebral fractures medRxiv. Orthop. Pub Date : 2023-06-06 Youhei Yoshimi, Takanori Matsuura, Kazuaki Miyazato, Shiho Takahashi, Nami Tanaka, Hanae Morinaga, Asuka Hayata, Minami Onishi, Yousuke Nagano, Hideo Ohnishi
Osteoporotic vertebral fractures in older patients impair activities of daily living because of low back pain and abnormal posture. Assessing pain using self-reported assessment tools is difficult, especially in patients with moderate-to-severe cognitive impairment. In recent years, observational assessment tools have been used when self-reported assessment tools were difficult to implement. However
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Wearable sensor and machine learning accurately estimate tendon load and walking speed during immobilizing boot ambulation medRxiv. Orthop. Pub Date : 2023-06-05 Michelle P. Kwon, Todd J. Hullfish, Casey J. Humbyrd, Lorraine A.T. Boakye, Josh R. Baxter
Achilles tendon injuries are treated with progressive weight bearing to promote tendon healing and restore function. Patient rehabilitation progression are typically studied in controlled, lab settings and do not represent the long-term loading experienced during daily living. The purpose of this study is to develop a wearable paradigm to accurately monitor Achilles tendon loading and walking speed
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An Endpoint Adjudication Committee for the Assessment of Computed Tomography Scans in Fracture Healing medRxiv. Orthop. Pub Date : 2023-06-05 Chloe Elliott, Ethan Patterson, Brenna Mattiello, Adina Tarcea, Bevan Frizzell, Richard E. Walker, Kevin A. Hildebrand, Neil J. White
The use of endpoint adjudication committees (EACs) has the potential to reduce subjectivity and potential bias in clinical research trials and contribute to a higher quality of research. In a recent randomized control trial (RCT), we used serial computed tomography (CT) imaging to visualize fracture healing of the scaphoid as a primary outcome. The scaphoid bone poses a challenge in the diagnosing
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Device-Measured Physical Activity in 3,511 Individuals with Knee or Hip Arthroplasty medRxiv. Orthop. Pub Date : 2023-06-03 Scott R. Small, Sara Khalid, Andrew J. Price, Aiden Doherty
Background Physical activity is a key contributor to overall health, with low activity levels associated with a higher risk of all-cause mortality. Hip and knee arthroplasty aims to reduce joint pain, increasing functional mobility and the ability to be more physically active. However, the degree to which arthroplasty is associated with higher physical activity is unclear. The current study sought
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Restored somatosensation in individuals with lower limb loss improves gait, speed perception, and motor adaptation medRxiv. Orthop. Pub Date : 2023-05-30 Daekyoo Kim, Ronald Triolo, Hamid Charkhkar
Lower limb loss is a significant insult to the body’s nervous and musculoskeletal systems. Despite technological advances in prosthesis design, artificial limbs are not yet integrated into the body’s physiological systems. Therefore, lower limb amputees (LLAs) experience lower balance confidence, higher fear of falls, and impaired gait mechanics compared to their able-bodied peers (ABs). Restoring
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Experimental and computational evaluation of knee implant wear and creep under in vivo and ISO boundary conditions medRxiv. Orthop. Pub Date : 2023-05-11 Michael J. Dreyer, Seyyed Hamed Hosseini Nasab, Philippe Favre, Fabian Amstad, Rowena Crockett, William R. Taylor, Bernhard Weisse
Experimental knee implant wear testing according to ISO 14243 is a standard procedure, but it inherently possesses limitations for preclinical evaluations due to extended testing periods and costly infrastructure. In an effort to overcome these limitations, we hereby develop and experimentally validate a finite element (FE) based algorithm, including a novel cross-shear and contact pressure dependent
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Efficacy of Intrawound Vancomycin in Prevention of Periprosthetic Joint Infection After Primary Total Knee Arthroplasty medRxiv. Orthop. Pub Date : 2023-05-08 Praharsha Mulpur, Tarun Jayakumar, Ramakanth R Yakkanti, Aditya Apte, Kushal Hippalgaonkar, Adarsh Annapareddy, A B Suhas Masilamani, A V Gurava Reddy
Introduction Peri-prosthetic Joint Infection (PJI) after total knee arthroplasty (TKA) is a devastating complication. Intra-wound vancomycin powder has been shown to reduce infection rates in spine surgery. Previous studies on the efficacy of local vancomycin powder in hip or knee arthroplasty are mostly retrospective case series. The aim of this prospective RCT was to evaluate the efficacy and safety
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Study protocol for comparison of post-operative pain between intraosseous multimodal injection and periarticular multimodal injection in Simultaneous Bilateral Total Knee Arthroplasty – A Randomized Controlled Trial medRxiv. Orthop. Pub Date : 2023-05-01 Patcharavit Ploynumpon, Vajara Wilairatana, Thakrit Chompoosang
Background: Total knee arthroplasty (TKA) was the procedure which is preform by orthopedic surgeons in end stage osteoarthritis knee patients who fail conservative treatment. Periarticular analgesia is one of the effective and safe technique used to reduce pain after surgery. However, the location and formula of the mixture have not yet been controversy. Recently, a study compared intraosseous analgesic
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The Comparison of enhanced recovery after surgery versus traditional pathway in early-onset scoliosis surgery medRxiv. Orthop. Pub Date : 2023-04-24 Keyi Jian, Jian Cui, Chunbin Li, Rong Liu
The optimized enhanced recovery after surgery (ERAS) pathway in patients with early onset scoliosis (EOS) has not yet been comprehensively described. This study explored the efficacy and feasibility of an integral process of the ERAS pathway in posterior spinal fusion (PSF) surgery in EOS patients. A total of 70 patients were included in this study, with 35 patients receiving treatment using an ERAS
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Low back pain service utilization and costs: association with timing of first-line services for individuals initially contacting a physician specialist. A retrospective cohort study medRxiv. Orthop. Pub Date : 2023-04-20 Dave Elton, Meng Zhang
Background: Physician specialists (PS) are often the type of healthcare provider initially contacted by an individual with low back pain (LBP). LBP clinical practice guidelines (CPG) recommend a stepped approach to management with an emphasis on first-line non-pharmaceutical and non-interventional services. Objective: Examine the association between the incorporation of CPG recommended first-line services