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FGFR2 and miR‐889‐3p expression in oral cancer is associated with cervical lymph node metastasis Oral Dis. (IF 3.8) Pub Date : 2024-03-16 Fariba Mehdikhani, Mostafa Atashbasteh, Mehdi Azadi, Abdolamir Allameh
ObjectiveFibroblast growth factor receptor‐2 (FGFR2) and miR‐889‐3p expression in oral squamous cell carcinoma (OSCC) tumours were compared to normal controls. We then examined the relationship between miR‐889‐3p, FGFR2 expression and patient clinicopathological features.Materials and MethodsThe interaction of FGFR2 and miR‐889‐3p was investigated using bioinformatics. Then, OSCC tumour biopsies and
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Evaluating the efficacy of OralDETECT training: Face‐to‐face versus online delivery in dental education Oral Dis. (IF 3.8) Pub Date : 2024-03-16 Anand Ramanathan, Zuraiza Mohamad Zaini, Wan Maria Nabillah Ghani, Gou Rean Wong, Nurul Izyan Zainuddin, Yi Hsin Yang, Rosnah Binti Zain
ObjectiveThis study evaluated the effectiveness of face‐to‐face (F2F) and online OralDETECT training programme in enhancing early detection skills for oral cancer.MethodsA total of 328 final‐year dental students were trained across six cohorts. Three cohorts (175 students) received F2F training from the academic years 2016/2017 to 2018/2019, and the remaining three (153 students) underwent online training
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Manganese drives ferroptosis of cancer cells via YAP/TAZ phase separation activated ACSL4 in OSCC Oral Dis. (IF 3.8) Pub Date : 2024-03-11 Hao Chen, Hao Cui, Wei Liu, Bo‐Wen Li, Zhen Tian, Yu‐Yue Zhao, Guang‐Tao Yu
ObjectiveFerroptosis has been defined as a novel form of regulated cell death characterized by iron‐dependent lipid peroxidation. Manganese has been used to induce ferroptosis in cancer cells recently. This study aims to investigate whether manganese can induce ferroptosis in oral squamous cell carcinoma (OSCC) and the underlying biological mechanisms.Materials and MethodsCancer cells with or without
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Oral health in COVID‐19 hospitalizations: A crucial link to patient well‐being and recovery Oral Dis. (IF 3.8) Pub Date : 2024-03-11 Paulo Ricardo Martins‐Filho, Lucas Alves da Mota Santana, Fábio Wildson Gurgel Costa
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Cathepsin K inhibition alleviates periodontal bone resorption by promoting type H vessel formation through PDGF‐BB/PDGFR‐β axis Oral Dis. (IF 3.8) Pub Date : 2024-03-11 Huan Zhou, Yi‐Fan Zhang, Qian‐Qian Zhang, Fen Liu, Jia‐Yu Zhang, Yue Chen
ObjectivesTo explore the effects of cathepsin K (CTSK) inhibition on type H vessel formation and alveolar bone resorption within periodontitis.MethodsConditioned media derived from preosteoclasts pretreated with the CTSK inhibitor odanacatib (ODN), ODN supplemented small interfering RNA targeting PDGF‐BB (si‐PDGF‐BB), or PBS were prepared, to assess their proangiogenic effects on endothelial cells
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COVID‐19 impact on post‐traumatic stress symptoms in burning mouth syndrome: A multicentric study Oral Dis. (IF 3.8) Pub Date : 2024-03-11 Giulia Ottaviani, Federica Canfora, Stefania Leuci, Noemi Coppola, Giuseppe Pecoraro, Katia Rupel, Magdalena Theodora Bogdan Preda, Veronica Vello, Albert Umberto, Roberta Gasparro, Margherita Gobbo, Luca Guarda‐Nardini, Amerigo Giudice, Elena Calabria, Massimo Aria, Luca D'Aniello, Giulio Fortuna, Matteo Biasotto, Roberto Di Lenarda, Michele Davide Mignogna, Daniela Adamo
ObjectivesThis study investigates the psychological impact of COVID‐19 on burning mouth syndrome (BMS) patients. It focuses on comparing post‐traumatic stress symptoms (PTSS), post‐traumatic growth (PTG), and resilience between BMS patients and Controls.MethodsA total of 100 BMS patients and 100 Controls from five Italian centers participated in this observational cross‐sectional study. They completed
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Epidemiology of oral cancer in South and South‐East Asia: Incidence and mortality Oral Dis. (IF 3.8) Pub Date : 2024-03-08 Adalberto M. Filho, Saman Warnakulasuriya
IntroductionThis study provides an epidemiological description of cancer in the lip, oral cavity, and oropharynx in the South and South‐East Asia region.MethodsThe number of new cases and deaths was extracted from the GLOBOCAN 2020 and the CI5 series. We present age‐standardized incidence and mortality rates per 100,000 inhabitants. To assess temporal trends, we estimated the annual percent change
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Life course social mobility, race and tooth loss in adulthood: The role of dental health services Oral Dis. (IF 3.8) Pub Date : 2024-03-05 Roger Keller Celeste, Antonio Fernando Boing, Karen Glazer Peres, Marco Aurelio Peres
ObjectivesTo evaluate the extent to which dental care factors in adulthood modify and, at the same time, mediate the association between race/ethnicity and social mobility from childhood to adulthood with two oral health outcomes in adults.MethodsIn 2012, 1222 individuals 20–59 years old participated in the second wave of the Epi‐Floripa Study in Florianopolis, Brazil. Exposures included social mobility
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Climate change and oral health: Assessing the impacts and developing strategies for adaptation Oral Dis. (IF 3.8) Pub Date : 2024-03-05 Delfin Lovelina Francis, Saravanan Sampoornam Pape Reddy, Anitha Logaranjani, Sukhbir Singh Chopra
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Subgingival biofilm microbiome in individuals with asthma and periodontitis: Metagenomic analysis Oral Dis. (IF 3.8) Pub Date : 2024-03-05 Giselle R. Pinto, Paulo C. Carvalho Filho, Rodrigo D. O. Carvalho, Rogério R. Conceição, Vitor Fortuna, Isaac S. Gomes‐Filho, Soraya C. Trindade, Viviane A. Sarmento
ObjectiveThis observational study aimed to explore the metagenomics of subgingival biofilms in individuals with varying degrees of asthma, from severe to none, to elucidate the association between the subgingival microbiome and asthma.Materials and MethodsSubgingival biofilm samples were collected from thirty participants at the Asthma Control Program Outpatient Clinic in Bahia (ProAR). These samples
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Oral mucosal changes in tight junction proteins in patients with oral lichen planus Oral Dis. (IF 3.8) Pub Date : 2024-03-05 Xiaomeng Ren, Kaiyi Li, Xin Fang, Zhengda Zhu, Qianming Chen, Chunlei Li, Hong Hua
ObjectiveThis study aimed to investigate the expression of tight junction, its distribution pattern in oral lichen planus samples and its potential association with the severity of oral lichen planus.Materials and MethodsCross‐sectional study designs were conducted. Transcriptome sequencing was conducted using oral mucosal tissues from 22 patients with oral lichen planus and 11 healthy controls. Immunohistochemistry
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Nuclear imaging to visualize periodontal inflammation: Findings of a randomized controlled trial Oral Dis. (IF 3.8) Pub Date : 2024-03-05 Behrouz Arefnia, Anja Horina, Tina Nazerani‐Zemann, Gerald Seinost, Marcus Rieder, Gernot Wimmer
ObjectiveTo investigate non‐surgical periodontal therapy by 18F‐fluorodeoxyglucose (2‐[18F]FDG) uptake using positron emission tomography (PET) integrated with computed tomography (CT).SubjectsEighty‐five patients with peripheral artery disease and severe periodontitis—randomized into three groups receiving therapy with (PT1; n = 29) or without (PT2; n = 28) systemic antibiotics or no treatment (controls:
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High frequency of stromal myofibroblasts in odontogenic keratocyst associated with an impacted tooth Oral Dis. (IF 3.8) Pub Date : 2024-03-05 Karina Helen Martins, Júlia Biliato Javaroni, Camila Oliveira Barbeiro, Roberto Henrique Barbeiro, Magdalena Raquel Torres Reyes, Ana Lia Anbinder, Rafaella Souza Guardia, Evânio Vilela Silva, Jorge Esquiche León, Andiara De Rossi
CONFLICT OF INTEREST STATEMENT The authors declare no competing interests.
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A review of animal models for burning mouth syndrome: Mechanistic insights and knowledge gaps Oral Dis. (IF 3.8) Pub Date : 2024-03-05 Linda Sangalli, Alesia V. Prakapenka, Akhilanand Chaurasia, Craig S. Miller
ObjectivesThe underlying mechanisms of burning mouth syndrome (BMS) remain unclear leading to challenges and unsatisfactory management. Current treatments focus primarily on symptom relief, with few consistently achieving a 50% reduction in pain. This review aims to explore animal models of BMS to gain a better understanding of the underlying mechanisms and to discuss potential and existing knowledge
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IRE1α inhibits osteogenic differentiation of mouse embryonic fibroblasts by limiting Shh signaling Oral Dis. (IF 3.8) Pub Date : 2024-03-04 Zhixiang Zhang, Xuan Zhang, Xiangzhen Wei, Chengbo Yu, Li Xiao, Jianmiao Liu, Yong Liu, Yingguang Cao, Ke Song
ObjectivesThis study aimed to investigate the effect of endoplasmic reticulum (ER) stress sensor inositol‐requiring enzyme 1α (IRE1α) on the sonic hedgehog N‐terminus (N‐Shh)‐enhanced‐osteogenic differentiation process in mouse embryonic fibroblasts (MEFs).Materials and MethodsOsteogenesis of MEFs was observed by alkaline phosphatase (ALP) staining, alizarin red staining, and Von Kossa staining assays
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Short and long effects of the COVID‐19 context on oral health‐related quality of life of adolescents Oral Dis. (IF 3.8) Pub Date : 2024-03-01 Marina Blanco Pohl, Thais Gioda Noronha‐Ramos, Jessica Klöckner Knorst, Marcia Farias Pereira Lito, Gabriela de Araujo, Bruno Emmanuelli, Thiago Machado Ardenghi, Fernanda Tomazoni
AimTo assess the immediate and late effects of the COVID‐19 pandemic on the oral health‐related quality of life (OHRQoL) of adolescents.DesignThis is a longitudinal study performed with adolescents (11–15 years old) from Southern Brazil who were evaluated before the COVID‐19 outbreak, and 3 (T2) and 15 (T3) months after the beginning of the pandemic. OHRQoL was assessed using the CPQ11‐14. Sociodemographic
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Awareness of dental complications with oral piercings Oral Dis. (IF 3.8) Pub Date : 2024-03-01 Manal Masood, Laurence J. Walsh, Sobia Zafar
ObjectivesTo investigate knowledge and awareness of dental complications with oral piercings among adults with oral piercings, a control population with no piercings and body‐piercing professionals in South‐East Queensland, Australia.MethodsParticipants recruited from public and private dental clinics and body‐piercing professionals from piercing centres in the same region completed questionnaires
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Anti‐resorptive therapy and MRONJ. A survey of the Italian Society of Periodontology and Implantology Oral Dis. (IF 3.8) Pub Date : 2024-03-01 L. Landi, G. Oteri, L. Barbato, N. Discepoli, A. M. Carrassi, M. Rigoni, F. Cairo, R. Cavalcanti, A. Crea, R. Gianserra, N. M. Sforza
ObjectivesAnti‐resorptive agents have been linked to the development of MRONJ in patients undergoing dental surgical procedures. This survey aims to explore the level of knowledge and experience of Italian Society of Periodontology and Implantology members in the management of patients treated with anti‐resorptive agents and with the risk of developing MRONJ.Materials and MethodsAn 18‐item questionnaire
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A scientometric analysis of oral cancer research in South/Southeast Asia and China in oral diseases Oral Dis. (IF 3.8) Pub Date : 2024-03-01 Wei Liu, Keyan Miao, Yue He
CONFLICT OF INTEREST STATEMENT None declared.
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Impact of dental clearance on bacteremia in hematopoietic cell transplantation Oral Dis. (IF 3.8) Pub Date : 2024-03-01 Yehuda Zadik, Andrey Krasovsky, Refael Cohen, Andra Rettman, Doron J. Aframian, Batia Avni, Avi Peretz, Naama Keshet
Infection is a concern in hematopoietic cell transplantation (HCT), being leading cause of morbidity and mortality (Gudiol et al., 2014). Consequently, guidelines recommend the pre-HCT elimination of oral infectious sites, known as dental clearance, in order to mitigate systemic dissemination (Rankin et al., 2008; Yamagata et al., 2006) and avert fatalities (Elad et al., 2008). Nevertheless, certain
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BRAFV600E mutation mediates invasive and growth features in ameloblastoma Oral Dis. (IF 3.8) Pub Date : 2024-03-01 Chen‐Xi Zhang, Lin‐Zhou Zhang, Hao Lin, Qi‐Wen Man, Bing Liu
ObjectivesAmeloblastoma (AM), a locally aggressive tumor with extensive growth capacity, causes significant damage to the jaw and affects facial appearance. Although the high prevalence of BRAF V600E mutation in AM is known, its specific impacts on patients with AM remain unclear. Thus, the present study investigated the role of BRAF V600E mutation, thereby focusing on its impact on AM invasion and
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Roles of SP/KLF transcription factors in odontoblast differentiation: From development to diseases Oral Dis. (IF 3.8) Pub Date : 2024-02-27 Xuefei Wang, Kaida Sun, Zekai Xu, Zhuo Chen, Wenzhi Wu
ObjectivesA zinc‐finger transcription factor family comprising specificity proteins (SPs) and Krüppel‐like factor proteins (KLFs) plays an important role in dentin development and regeneration. However, a systematic regulatory network involving SPs/KLFs in odontoblast differentiation has not yet been described. This review examined the expression patterns of SP/KLF gene family members and their current
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Fusobacterium nucleatum dysregulates inflammatory cytokines and NLRP3 inflammasomes in oral cells Oral Dis. (IF 3.8) Pub Date : 2024-02-27 Jingzhuo Sun, Susu Feng, Tian Ding, Ting Wang, Lingqian Du, Wenyan Kang, Shaohua Ge
ObjectiveThis study aimed to clarify the difference in Fusobacterium nucleatum (F. nucleatum) induced inflammatory cytokines and nod‐like receptor protein 3 (NLRP3) inflammasomes dysregulation among three periodontal cells.MethodsOral epithelial cells (HIOECs), THP‐1 macrophages, and human gingival fibroblasts (HGFs) were exposed to F. nucleatum with/without adenosine triphosphate (ATP) and nigericin
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A real‐life experience of long‐term use of pilocarpine in irradiated head and neck cancer patients Oral Dis. (IF 3.8) Pub Date : 2024-02-27 Rungarun Kittichet, Imjai Chitapanarux, Kittikun Kittidachanan, Patumrat Sripan
AimsTo assess long‐term efficacy and side effects of pilocarpine on irradiated head and neck cancer (HNC) patients in both for prevention and treatment of radiation‐induced xerostomia (RIX).MethodsRetrospective observational study was conducted. Eligibility criteria included irradiated HNC patients who received pilocarpine at least 12 weeks either for prevention (group A) or for treatment (group B)
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Efficacy of adjunctive modalities during tooth extraction for the prevention of osteoradionecrosis: A systematic review and meta‐analysis Oral Dis. (IF 3.8) Pub Date : 2024-02-24 Bernadette Quah, Chee Weng Yong, Clement Wei Ming Lai, Intekhab Islam
BackgroundJaw osteoradionecrosis (ORN) is a complication in patients with previous head and neck radiotherapy. Its incidence increases with dental extractions. Hence, this review aimed to evaluate the efficacy of adjunctive treatment modalities undertaken at the time of extraction in previous head and neck radiotherapy patients in preventing ORN.MethodsA systematic review was conducted, where studies
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Photobiomodulation alleviates Burning Mouth Syndrome pain: Immediate and weekly outcomes explored Oral Dis. (IF 3.8) Pub Date : 2024-02-24 Ori Finfter, Layla Kizel, Rakefet Czerninski, Shimrit Heiliczer, Yair Sharav, Rafael Cohen, Doron J. Aframian, Yaron Haviv
Burning Mouth Syndrome (BMS) is an intraoral chronic burning or dysesthetic sensation, without clinically evident causative lesions on clinical examination and investigation.AimTo assess immediate and weekly effects of photobiomodulation (PBM) on BMS patients.MethodsThirty BMS patients were treated intra‐orally with photobiomodulation 940(±10) nm (InGaAsP) 3 W, semi‐conductor diode, weekly, for up
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Barriers to early diagnosis and management of oral cancer in Latin America and the Caribbean Oral Dis. (IF 3.8) Pub Date : 2024-02-21 Josefina Martínez‐Ramírez, Cristina Saldivia‐Siracusa, Leonor‐Victoria González‐Pérez, Florence Juana Maria Cuadra Zelaya, Roberto Gerber‐Mora, Osmani Fabricio Guevara Cabrera, Ronell Bologna‐Molina, Gerardo Gilligan, Wilson Delgado‐Azañero, Arvind Babu Rajendra Santosh, Wilfredo Alejandro González‐Arriagada, Mariana Villarroel‐Dorrego, Bernardo Venegas Rojas, Karen Patricia Domínguez Gallagher, Elena
ObjectiveThis study aimed to explore perceived barriers to early diagnosis and management of oral cancer, as well as potential pathways for improvement in Latin America and the Caribbean (LAC).MethodsThis cross‐sectional study used a self‐administered online questionnaire created via the Research Electronic Data Capture platform. The survey was distributed to health professionals trained in Oral Medicine
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Oral submucosal fibrosis: An updated molecular mechanism on pathogenesis and treatment modalities Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Vadivel Jayanth Kumar, Devaraj Ezhilarasan, Deepak Nallasamy Veeraiyan
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Reply to the editor: Potential contributors to implant losses following radiotherapy or chemoradiotherapy Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Jamie M. Alberga, Arjan Vissink, Anke Korfage, Sebastiaan A. H. J. de Visscher, Max J. H. Witjes, Johannes A. Langendijk, Gerry M. Raghoebar
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Influence of oral condition on the quality of life of patients hospitalized for COVID‐19 Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Lara Ribeiro Feitosa Duailibe, Laise Nunes Rodrigues, Alanna Barros de Arruda, Robinson Sabino‐Silva, Rayenne Augusta Mota Ferreira, Rudys Rodolfo de Jesus Tavarez, Cyrene Piazera Silva Costa, Meire Coelho Ferreira
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Potential contributors to implant losses following radiotherapy or chemoradiotherapy Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Erkan Topkan, Efsun Somay, Uğur Selek
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Histone‐modifying enzymes: Roles in odontogenesis and beyond Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Yiting Li, Pengcheng He, Liwei Zheng, Xin Zhou
ObjectivesOdontogenesis, an intricate process initiated by epithelium‐mesenchyme interaction, is meticulously regulated by a cascade of regulatory mechanisms. Epigenetic modifications, especially histone modification, have been found to exhibit spatiotemporal specificity during tooth development. However, the expression patterns and roles of enzymes associated with histone modifications have yet to
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METTL3 inhibitor STM2457 impairs tumor progression and enhances sensitivity to anlotinib in OSCC Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Lianlian Liu, Tingting Zhao, Siyi Zheng, Dongxiao Tang, Hui Han, Chunlong Yang, Xin Zheng, Juan Wang, Jieyi Ma, Wei Wei, Zhaoyu Wang, Shuqi He, Qianting He
ObjectivesTo investigate the inhibitory effects of STM2457, which is a novel METTL3 (m6A writer) inhibitor, both as a monotherapy and in combination with anlotinib, in the treatment of oral squamous cell carcinoma (OSCC) both in vitro and in vivo.Materials and MethodsThe efficacy of STM2457 or STM2457 plus anlotinib was evaluated using two OSCC cell lines by CCK8, transwell, colony formation, would‐healing
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Linagliptin's impact on lymphatic barrier and lymphangiogenesis in oral cancer with high glucose Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Hongyu Wang, Xiao She, Qiongdong Xu, Xingyu Zhou, Qinchao Tang, Huakun Wei, Tianjing Huang, Feixin Liang
ObjectivesUncertainties remain regarding the effect of elevated glucose levels on lymphatic metastasis of cancer cells. Our study elucidated the mechanisms linking high glucose to lymphangiogenesis and lymphatic barrier‐related factors and investigated the protective role of linagliptin against lymphatic barrier dysfunction.Materials and MethodsA CAL‐27‐LEC co‐culture system was established. Sodium
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Zoledronic acid enhances tumor growth and metastatic spread in a mouse model of jaw osteosarcoma Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Than‐Thuy Nham, Romain Guiho, Régis Brion, Jérôme Amiaud, Bénédicte Brounais Le Royer, Anne Gomez‐Brouchet, Françoise Rédini, Hélios Bertin
ObjectivesInvestigation of the therapeutic effect of zoledronic acid (ZA) in a preclinical model of jaw osteosarcoma (JO).Materials and MethodsThe effect of 100 μg/kg ZA administered twice a week was assessed in a xenogenic mouse model of JO. The clinical (tumor growth, development of lung metastasis), radiological (bone microarchitecture by micro‐CT analysis), and molecular and immunohistochemical
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USP14 promotes the cancer stem‐like cell properties of OSCC via promoting SOX2 deubiquitination Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Chang Liu, Shijie Zhou, Wei Tang
ObjectiveUSP14 (Ubiquitin‐specific‐processing protease 14) is a deubiquitinating enzyme with oncogenic effects in oral squamous cell carcinoma (OSCC). This study aims to identify new substrates of USP14 and elucidate their role in modulating cancer stem‐like cells (CSCs) in OSCC.Materials and MethodsBioinformatics prediction and docking were performed using UbiBrowser 2.0 and HDOCK, respectively. OSCC
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Application of metabolomics in oral squamous cell carcinoma Oral Dis. (IF 3.8) Pub Date : 2024-02-20 Guanfa Luo, Shuai Wang, Wen Lu, Wei Ju, Jianhong Li, Xiao Tan, Huiting Zhao, Wei Han, Xihu Yang
BackgroundOral squamous cell carcinoma (OSCC) is a prevalent malignancy affecting the head and neck region. The prognosis for OSCC patients remains unfavorable due to the absence of precise and efficient early diagnostic techniques. Metabolomics offers a promising approach for identifying distinct metabolites, thereby facilitating early detection and treatment of OSCC.ObjectiveThis review aims to provide
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Cross-cultural adaptation of the Thai Xerostomia Inventory and Summated Xerostomia Inventory Oral Dis. (IF 3.8) Pub Date : 2024-02-11 Chotima Lapnimitanun, Paswach Wiriyakijja, Oranart Matangkasombut, Orapin Komin
To cross-culturally adapt and validate the Thai version of the Xerostomia Inventory (XI) and Summated Xerostomia Inventory (SXI) for subjective evaluation of oral dryness in Thai middle-aged and older adults.
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The effect of c-Fos on the prognosis, proliferation, and invasion of oral squamous cell carcinoma Oral Dis. (IF 3.8) Pub Date : 2024-02-07 Lu Peng, Ercan Sun, Jinfang Zhang, Lanyu Cai, Jun Zheng, Yan Zeng
This study aimed to determine the role of c-Fos in growth and invasion of oral squamous cell carcinoma (OSCC).
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Oral manifestations after vaccinations: A systematic review of observational studies Oral Dis. (IF 3.8) Pub Date : 2024-02-06 Sabrina Messina, Patrizia Natale, Giusi Graziano, Sara Galleggiante, Giovanni F. M. Strippoli, Massimo Petruzzi
This study aimed to assess the prevalence and types of oral adverse events following immunization (AEFIs) in people who received at least one dose of any type of vaccine.
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Sodium fluoride-induced autophagy of ameloblast-like cells via the p-ULk1/ATG13/LC3B pathway in vitro Oral Dis. (IF 3.8) Pub Date : 2024-02-06 S. Yang, D. Song, R. Wang, M. Liu, T. Tan, Y. Wang, Q. Xie, L. Wang
To investigate the effects of sodium fluoride on the ameloblast and reveal the mechanism of dental fluorosis.
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Maternal periodontitis potentiates monosodium glutamate-obesity damage on Wistar offspring's fast-glycolytic muscle Oral Dis. (IF 3.8) Pub Date : 2024-02-05 Liziane Nunes Conrad Costa, Thayná Petry de Paula, Matheus Felipe Zazula, Katya Naliwaiko, Carlos Augusto Nassar, Gladson Ricardo Flor Bertolini, Marcia Miranda Torrejais, Lucinéia de Fátima Chasko Ribeiro, Rose Meire Costa
To evaluate the effects of magnifying the damage caused by obesity induced by monosodium glutamate, using a model of maternal periodontitis, on the structure of the anterior tibialis muscle of the offspring.
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Italian position paper (SIPMO-SICMF) on medication-related osteonecrosis of the jaw (MRONJ) Oral Dis. (IF 3.8) Pub Date : 2024-02-05 Alberto Bedogni, Rodolfo Mauceri, Vittorio Fusco, Francesco Bertoldo, Giordana Bettini, Olga Di Fede, Antonio Lo Casto, Claudio Marchetti, Vera Panzarella, Giorgia Saia, Paolo Vescovi, Giuseppina Campisi
This paper aims to describe the 2023 update position paper on MRONJ developed by the Italian Societies of Oral Pathology and Medicine (SIPMO) and of Maxillofacial Surgery (SICMF).
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Protein arginine methyltransferase 5 in osteoblasts promotes the healing of extraction sockets Oral Dis. (IF 3.8) Pub Date : 2024-01-31 Jie Yang, Shurong Yang, Xuejun Ge, Lu Yuan, Yini Qi, Zhen Huang, Guan Yang, Ran Zhang
To explore the effect of protein arginine methyltransferase 5 (PRMT5) on tooth extraction sockets healing, we established an extraction sockets model in osteoblast-conditional Prmt5 knockout mice. The results provided clues for promoting extraction sockets healing in clinical settings.
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NAT10/CEBPB/vimentin signalling axis promotes adenoid cystic carcinoma malignant phenotypes in vitro Oral Dis. (IF 3.8) Pub Date : 2024-01-29 Min Fu, Qian Gao, Mian Xiao, Xin-Yi Sun, Sheng-Lin Li, Xi-Yuan Ge
To explore the biological function and mechanisms of CEBPB and NAT10-mediated N4-acetylcytidine (ac4c) modification in salivary adenoid cystic carcinoma (SACC).
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IFT80 promotes early bone healing of tooth sockets through the activation of TAZ/RUNX2 pathway Oral Dis. (IF 3.8) Pub Date : 2024-01-29 Ziwei Zhao, Ying Geng, Qiaoqi Ni, Yue Chen, Yanan Cao, Yahui Lu, Hua Wang, Ruixia Wang, Wen Sun
Intraflagellar transport (IFT) proteins have been reported to regulate cell growth and differentiation as the essential functional component of primary cilia. The effects of IFT80 on early bone healing of extraction sockets have not been well studied. To investigate whether deletion of Ift80 in alveolar bone-derived mesenchymal stem cells (aBMSCs) affected socket bone healing, we generated a mouse
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Temporomandibular joint disorders and associated factors in a Turkish pediatric population Oral Dis. (IF 3.8) Pub Date : 2024-01-29 Damla Torul, Muhammed Furkan Yılmaz, Emine Örnek Akdoğan, Mehmet Melih Omezli
To explore the presence and severity of temporomandibular disorders (TMD) signs and symptoms in a Turkish pediatric population, as well as their relationship to parafunctional behaviors, bruxism, malocclusion, anxiety, and sociodemographic traits.
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Live dietary microbes and reduced prevalence of periodontitis: A cross-sectional study Oral Dis. (IF 3.8) Pub Date : 2024-01-23 Jie Lin, Hui Yang, Zhengshen Lin, Lingqiao Xu
Investigate the link between live dietary microbe consumption and the prevalence of periodontitis.
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The genetic and immune features of salivary gland secretory carcinoma with high-grade transformation Oral Dis. (IF 3.8) Pub Date : 2024-01-23 Yu Wang, Jingjing Sun, Bao Sun, Chunye Zhang, Zhen Tian, Lizhen Wang, Jiang Li
To compare the clinicopathological, molecular, and immune features of conventional and high-grade transformation (HGT) secretory carcinoma (SC) in salivary glands.
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Analysis of joint protein expression profile in anterior disc displacement of TMJ with or without OA Oral Dis. (IF 3.8) Pub Date : 2024-01-22 Luxiang Zou, Kaiwen Yang, Yeke Yu, Chuyao Wang, Jieyun Zhao, Chuan Lu, Dongmei He
Anterior disc displacement (ADD) is a common clinical issue and may cause osteoarthritis (OA). However, the research of protein changes in synovial fluid as disease development marker and potential treatment clue is still insufficient.
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Notch signaling regulates mineralization via microRNA modulation in dental pulp stem cells Oral Dis. (IF 3.8) Pub Date : 2024-01-19 Promphakkon Kulthanaamondhita, Chatvadee Kornsuthisopon, Ajjima Chansaenroj, Ravipha Suwittayarak, Voraphat Trachoo, Jeeranan Manokawinchoke, Seung-Cheol Lee, Hiroshi Egusa, Jin Man Kim, Thanaphum Osathanon
This study investigated the miRNA expression profile in Notch-activated human dental stem pulp stem cells (DPSCs) and validated the functions of miRNAs in modulating the odonto/osteogenic properties of DPSCs.
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ALDH3A1 upregulation inhibits neutrophils N2 polarization and halts oral cancer growth Oral Dis. (IF 3.8) Pub Date : 2024-01-15 Ying He, Yi Qu, Shan Jin, Yongfeng Zhang, Lizheng Qin
Tumor-associated neutrophils (TANs) are among the most abundant inflammatory cells in tumor microenvironment (TME). Aldehyde dehydrogenase 3A1 (ALDH3A1) is significantly reduced in oral squamous cell carcinoma (OSCC), ALDH3A1 overexpression suppresses tumorigenesis by inhibiting inflammation. This study investigated the relationship and mechanisms underlying the crosstalk between ALDH3A1 and TANs in
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Periodontitis and postoperative inflammation in gastric cancer patients: Propensity score analysis Oral Dis. (IF 3.8) Pub Date : 2024-01-15 Mio Sasaki, Hideo Shigeishi, Hiromi Nishi, Natsuki Hamada, Honami Kitasaki, Kanako Yano, Yoshino Kaneyasu, Susumu Horikoshi, Hiroyuki Kawaguchi, Kouji Ohta
The objective of this study was to clarify the association between preoperative periodontitis and postoperative systemic inflammation in patients with gastric cancer.
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Acromegaly: Overview and associated temporomandibular joint disorders Oral Dis. (IF 3.8) Pub Date : 2024-01-15 Malak Al-Hadlaq, Herve Sroussi
To provide a review on acromegaly and its orofacial manifestations, with a focus on associated arthropathies and temporomandibular joint disorders (TMD).
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Optical coherence tomography: Promising imaging technique for the diagnosis of oral mucosal diseases Oral Dis. (IF 3.8) Pub Date : 2024-01-08 Xu-Ya Chen, Gang Zhou, Jing Zhang
This review aims to summarize the latest application of optical coherence tomography (OCT) in oral mucosal diseases, promoting an accurate and earlier diagnosis of such disorders, which are difficult to be differentiated.
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Diagnosis of differentiated dysplasia as a variant of oral epithelial dysplasia Oral Dis. (IF 3.8) Pub Date : 2024-01-08 Anne-Sophie Becker, Maximiliane Holm, Jan Liese, Nadja Engel, Annette Helene Zimpfer
The World Health Organization's definition of oral epithelial dysplasia includes differentiated dysplasia, which is defined by purely architectural abnormalities of oral mucosa without cytological changes. We analysed differentiated dysplasia's frequency, progression risk and correlation with oral brush cytology.
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The association between chronotype profile and temporomandibular disorders among college students Oral Dis. (IF 3.8) Pub Date : 2024-01-08 Ruichen Dan, Jiaheng Li, Kangning Zhao, Zijiang Yang, Yanhua Dong, Peidi Fan, Qiaoyu Cheng, Jun Wang, Xin Xiong
Temporomandibular joint disorders (TMDs) are common in young adults, and the link between chronotype profile and TMDs is unclear.
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Association between periodontal disease and malignant soft tissue sarcomas Oral Dis. (IF 3.8) Pub Date : 2024-01-08 Takatoshi Hiroshimaya, Yusuke Fujimoto, Hiromi Sasaki, Toshihiro Motoi, Emi Nagata, Noboru Taniguchi, Takahiko Oho
Malignant soft tissue sarcoma (MSTS) is a rare disease, but is seen in patients undergoing orthopedic surgery. Although the association of periodontal disease with various cancers occurring in the oral cavity, gastrointestinal tract, lungs, and prostate, has been reported, the association between periodontal disease and MSTS remains unclear. This study investigated the association between periodontal
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E-cadherin and TAC in GCF accurately discriminate periodontal health and disease Oral Dis. (IF 3.8) Pub Date : 2024-01-05 Hind R. Hussein, Ali A. Abdulkareem, Mike R. Milward, Paul R. Cooper
To investigate the accuracy of gingival crevicular fluid (GCF) E-cadherin and total antioxidant capacity (TAC) to discriminate periodontal health from disease.