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ZNF862 induces cytostasis and apoptosis via the p21‐RB1 and Bcl‐xL‐Caspase 3 signaling pathways in human gingival fibroblasts J. Periodont. Res. (IF 3.5) Pub Date : 2024-03-14 Yaoyao Zhu, Tian Zhao, Yongkang Wu, Sijing Xie, Weibin Sun, Juan Wu
ObjectiveThis study investigates the effects of ZNF862 on the proliferation and apoptosis of human gingival fibroblasts and their related mechanisms.BackgroundAs a major transcription factor family, zinc finger proteins (ZFPs) regulate cell differentiation, growth, and apoptosis through their conserved zinc finger motifs, which allow high flexibility and specificity in gene regulation. In our previous
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A photoresponsive recombinant human amelogenin‐loaded hyaluronic acid hydrogel promotes bone regeneration J. Periodont. Res. (IF 3.5) Pub Date : 2024-03-14 Tung‐Liang Hsia, Zhikai Lin, Yiru Xia, Rong Shu, Yufeng Xie
ObjectivesIn order to evaluate the effect of methacrylated hyaluronic acid (HAMA) hydrogels containing the recombinant human amelogenin (rhAm) in vitro and in vivo.BackgroundThe ultimate goal in treating periodontal disease is to control inflammation and achieve regeneration of periodontal tissues. In recent years, methacrylated hyaluronic acid (HAMA) containing recombinant human amyloid protein (rhAm)
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Welcome to the new protagonists of the Journal of Periodontal Research: Our Associate Editors and Editorial Board members! J. Periodont. Res. (IF 3.5) Pub Date : 2024-03-13 Mario Romandini
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Lipotoxicity: The missing link between diabetes and periodontitis? J. Periodont. Res. (IF 3.5) Pub Date : 2024-02-29 Yu Sun, Yuanyuan Yin, Sihan Yang, Dongqing Ai, Han Qin, Xuyun Xia, Xiaohui Xu, Jinlin Song
Lipotoxicity refers to the accumulation of lipids in tissues other than adipose tissue (body fat). It is one of the major pathophysiological mechanisms responsible for the progression of diabetes complications such as non‐alcoholic fatty liver disease and diabetic nephropathy. Accumulating evidence indicates that lipotoxicity also contributes significantly to the toxic effects of diabetes on periodontitis
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Autoinducer‐2 produced by oral microbial flora and alveolar bone loss in periodontitis J. Periodont. Res. (IF 3.5) Pub Date : 2024-02-27 Cheng Li, Hancheng Zhou, Huiqing Gou, Zixin Fan, Yifei Zhang, Pengzhou Tang, Jiaxin Huang, Yan Xu, Lu Li
ObjectiveThe aim of this study was to investigate the association between autoinducer‐2 (AI‐2) of oral microbial flora and the alveolar bone destruction in periodontitis to determine if AI‐2 may have the potential that monitor periodontitis and predict bone loss.BackgroundPlaque biofilm was the initiating factor of periodontitis and the essential factor of periodontal tissue destruction. The formation
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The effect of interleukin-20 on periodontal tissue destruction in individuals with periodontitis J. Periodont. Res. (IF 3.5) Pub Date : 2024-02-14 H. Yemenoglu, R. Senkal, O. Kose, A. Yılmaz, S. Mataracı Karakaş, K. Akyıldız
Periodontitis is an inflammatory disease that destroys periodontal tissues. Interleukin-20 (IL-20), on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. This study aimed to evaluate the effect of IL-20 on periodontal
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Octacalcium phosphate collagen composite for periodontal regeneration in a canine one-wall intrabony defect J. Periodont. Res. (IF 3.5) Pub Date : 2024-02-14 Daichi Yamaki, Shunsuke Fukuba, Munehiro Okada, Shunsuke Takeuchi, Shu Hoshi, Takanori Matsuura, Takanori Iwata
This study aimed to evaluate the regenerative capacities of octacalcium phosphate collagen composite (OCP/Col) in one-wall intrabony defects in dogs. The background data discuss the present state of the field: No study has assessed the efficacy of OCP/Col for periodontal regeneration therapy despite the fact that OCP/Col has proved to be efficient for bone regeneration.
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Phytocannabinoids and gingival inflammation: Preclinical findings and a placebo-controlled double-blind randomized clinical trial with cannabidiol J. Periodont. Res. (IF 3.5) Pub Date : 2024-02-05 Petr Jirasek, Alexandr Jusku, Jana Frankova, Marketa Urbankova, Daniel Diabelko, Filip Ruzicka, Barbora Papouskova, Karin Chytilova, Jiri Vrba, Jakub Havlasek, Katerina Langova, Jan Storch, Iva Voborna, Vilim Simanek, Jan Vacek
The aim of this study was to: (1) evaluate the anti-inflammatory effects of cannabidiol (CBD) on primary cultures of human gingival fibroblasts (HGFs) and (2) to clinically monitor the effect of CBD in subjects with periodontitis.
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Abnormal amyloid precursor protein processing in periodontal tissue in a murine model of periodontitis induced by Porphyromonas gingivalis J. Periodont. Res. (IF 3.5) Pub Date : 2024-02-04 Hui Shen, Yiting Jiang, Che Qiu, Xinyi Xie, Huanyu Zhang, Zhiyan He, Zhongchen Song, Wei Zhou
The study aimed to investigate the change of amyloid precursor protein (APP) processing and amyloid β (Aβ) metabolites in linking periodontitis to Alzheimer's disease (AD).
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Hepatocyte growth factor is protective in early stage but bone-destructive in late stage of experimental periodontitis J. Periodont. Res. (IF 3.5) Pub Date : 2024-01-19 Xiaomin Zhao, Weijia Liu, Zhicong Wu, Xiaoxi He, Yinghua Tang, Qian He, Chuyin Lin, Yannan Chen, Gang Luo, Ting Yu, Xinhong Wang
Clinical studies found high levels of hepatocyte growth factor (HGF) expression in patients with periodontitis. Studies suggest that HGF plays an important role in periodontitis, is involved in inflammation, and modulates alveolar bone integrity in periodontitis. This study aims to investigate the effects and mechanisms of HGF in the progression of experimental periodontitis.
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Oxytocin alleviates periodontitis in adult rats J. Periodont. Res. (IF 3.5) Pub Date : 2024-01-16 Ganna Dmytrenko, Javier Fernández-Solari, Fernando Correa, Andrea De Laurentiis
The objective of the study was to evaluate the expression of oxytocin receptors in normal and inflamed gingiva, as well as the effects of systemic administration of oxytocin in bone loss and gum inflammatory mediators in a rat model of experimental periodontitis.
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Preventive effects of melatonin on periodontal tissue destruction due to psychological stress in rats with experimentally induced periodontitis J. Periodont. Res. (IF 3.5) Pub Date : 2024-01-12 Semih Alperen Bostan, Hatice Yemenoglu, Oğuz Kose, Kerimali Akyildiz, Tolga Mercantepe, Sinan Saral, Levent Tumkaya, Adnan Yilmaz
Psychological stress is a potential modifiable environmental risk factor causally related to the exacerbation of periodontitis and other chronic inflammatory diseases. This animal study aimed to investigate comprehensively the preventive efficacy of systemic melatonin administration on the possible effects of restraint stress on the periodontal structures of rats with periodontitis.
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Reuterin isolated from the probiotic Lactobacillus reuteri promotes periodontal tissue regeneration by inhibiting Cx43-mediated the intercellular transmission of endoplasmic reticulum stress J. Periodont. Res. (IF 3.5) Pub Date : 2024-01-09 Nannan Han, Yitong Liu, Xiaoyan Li, Juan Du, Lijia Guo, Yi Liu
The present study aimed to evaluate the effects of reuterin, a bioactive isolated from the probiotic Lactobacillus reuteri (L. reuteri) on periodontal tissue regeneration, and provide a new strategy for periodontitis treatment in the future.
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Periodontitis and thyroid function: A bidirectional Mendelian randomization study J. Periodont. Res. (IF 3.5) Pub Date : 2024-01-09 Yan Gao, Donghai Huang, Yong Liu, Yuanzheng Qiu, Shanhong Lu
Previous studies suggest interaction between periodontitis and thyroid function, while the causality has not yet been established. We applied the Mendelian randomization (MR) method to assess bidirectional causal association between periodontitis and thyroid-related traits, including free thyroxine (FT4), thyroid stimulating hormone (TSH), hypothyroidism, hyperthyroidism and autoimmune thyroid disease
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Effectiveness of novel oral hygiene instruction avoiding inattentional blindness using an application for unique plaque control record calculation: A randomized clinical trial J. Periodont. Res. (IF 3.5) Pub Date : 2024-01-08 Akio Mitani, Takato Matsuura, Makoto Aino, Jun-ichiro Hayashi, Eisaku Nishida, Miki Hori, Takeshi Kikuchi
This study was performed to estimate the effectiveness of novel oral hygiene instruction (OHI) focusing on areas with deep periodontal pockets for reduction of periodontal inflammation.
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Potential diagnostic markers and therapeutic targets for periodontitis and Alzheimer's disease based on bioinformatics analysis J. Periodont. Res. (IF 3.5) Pub Date : 2024-01-08 Kai Yang, Zhaoqi Zhang, Qingyuan Zhang, Hongyu Zhang, Xiaoju Liu, Zhicheng Jia, Zhenhao Ying, Wei Liu
As a chronic inflammatory disease, periodontitis threatens oral health and is a risk factor for Alzheimer's disease (AD). There is growing evidence that these two diseases are closely related. However, current research is still incomplete in understanding the common genes and common mechanisms between periodontitis and AD. In this study, we aimed to identify common genes in periodontitis and AD and
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Dipotassium glycyrrhizate and hinokitiol enhance macrophage efferocytosis by regulating recognition, uptake, and metabolism of apoptotic cells in vitro J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-25 Yu Yamamoto, Tsuguno Yamaguchi, Kenji Egashira, Shuhei Saiki, Mitsuo Kimura, Takashi Chikazawa, Yukio Yamamoto, Kei Kurita
Efferocytosis is a process whereby macrophages remove apoptotic cells, such as neutrophils, that have accumulated in tissues, which is required for resolution of inflammation. Efferocytosis is impaired in individuals with increasing age and in those with various systemic diseases. Recently, efferocytosis has been reported to be related to the pathogenesis and progression of periodontitis, and enhancement
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Periostin in the relation between periodontal disease and atherosclerotic coronary artery disease: A pilot randomized clinical study J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-22 Miguel Padial-Molina, Gloria Gonzalez-Perez, Natividad Martin-Morales, Elena Sanchez-Fernandez, Francisco O'Valle, Pablo Galindo-Moreno
The aim of this study was to analyze the effects of periodontal treatment on markers of atherosclerotic coronary artery disease and circulating levels of periostin.
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Ibero-Panamerican Federation of Periodontology Delphi study on the trends of periodontology and periodontics by the year 2030. A Latin American consensus J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-22 Lilian Málaga-Figueroa, Marco Antonio Alarcón, Claudio Mendes Pannuti, Patricia Horna, Andrea López-Pacheco, Mariel Gómez, Paola Jiménez, Giuseppe Alexandre Romito, Elizabeth Lozano, Andrés Duque, Mauricio Montealegre, Marco Vinicio Medina Vega, Roberto Galindo, Vilma Umanzor, Agustín Zerón, Carlos Barrios, Mónica Shedden, Ruth Castillo, James Collins, Luis Bueno, Xiomara Giménez, Mariano Sanz, David
As elsewhere in the world, the prevalence of periodontitis in stages I–II is high in the Latin American population, this scenario emphasizes the need for identification of urgent needs for allocating adequate resources to provide diagnosis, prevention, and treatment of these diseases. The aim of this Delphi study was to predict the trends in periodontology/periodontics in the Latin American region
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Variability in human tooth cementum thickness reflecting functional processes J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-21 Nicole Nicklisch, Christopher Hinrichs, Lukas Palaske, Werner Vach, Kurt W. Alt
The aim of this study was to investigate the thickness of acellular extrinsic fibre cementum (AEFC) at four root positions of anterior and posterior teeth with special focus on functional aspects. Furthermore, the correlations between cementum thickness and chronological age and sex are investigated.
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The evaluation of salivary leucine-rich alpha-2 glycoprotein (LRG) and C-reactive protein (CRP) in humans with periodontal health or periodontal disease J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-21 Ece Özer, Huriye Erbak Yilmaz, Figen Narin, Mehmet Sağlam
The purpose of the present research is to evaluate the salivary levels of leucine-rich alpha-2 glycoprotein (LRG) and C-reactive protein (CRP) in periodontal health and disease (gingivitis and stage III periodontitis) and also to compare the discriminative efficiencies of both biomarkers in periodontal disease.
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Alterations in oxidative stress biomarkers and helper T-cell subgroups in patients with periodontitis and IgA nephropathy J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-20 Jinfeng Li, Yanjun Zhang, Hao Lu, Zhiwei Li, Hui Luo, Qianqiu Ou, Xiaotao Chen
Investigating the changes in the oxidative stress levels and helper T lymphocyte (Th) subsets in patients with periodontitis and IgA nephropathy (IgAN) to determine their relationship.
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Effects of amoxicillin and metronidazole as an adjunct to scaling and root planing on glycemic control in patients with periodontitis and type 2 diabetes: A short-term randomized controlled trial J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-19 Xinran Xu, He Lu, Pengcheng Huo, Dongsiqi Jin, Yunxuan Zhu, Huanxin Meng
To assess the effects of amoxicillin and metronidazole with scaling and root planing (SRP) on periodontal parameters and glycemic control in patients with severe periodontitis and diabetes mellitus.
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A Mendelian randomization study between chronic periodontitis and non-alcoholic fatty liver disease J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-15 Li Tan, Yunbo He, Tianyi Wang, Xianhua Gao, Wei Fan, Bing Fan
Observational studies have suggested a potential association between non-alcoholic fatty liver disease (NAFLD) and chronic periodontitis (CP). However, these studies are prone to confounding factors. The aim of this study was to assess the causal relationship between NAFLD and CP using a two-sample bidirectional Mendelian randomization (MR) analysis method.
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Developmental endothelial locus-1 promotes osteogenic differentiation and alveolar bone regeneration in experimental periodontitis with type 2 diabetes mellitus J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-15 Qian Ma, Yiyao Hu, Han Li, Yunchun Kuang, Jie Li, Jinlin Song
This study sought to explore the role of developmental endothelial locus-1 (DEL-1) in osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and investigate the therapeutic effect of DEL-1 in ligature-induced experimental periodontitis with type 2 diabetes mellitus (T2DM).
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Identifying genes for regulating osteogenic differentiation of human periodontal ligament stem cells in inflammatory environments by bioinformatics analysis J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-11 Qing Wang, Xiaojie Yang, Xuechun Wang, Xuan Wang, Jie Zhang, Ya Gao, Jinsong Pan, Shiwei Wang
Periodontitis is an immuno-inflammatory disease caused by dental plaque biofilms and inflammations. The regeneration of bone tissue in inflammatory environment is of great significance for the treatment of periodontal disease, but the specific molecular mechanism of bone formation in periodontitis still needs further exploration. The objective of this study was to identify key osteogenesis-related
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Hyaluronic acid enhances cell migration, viability, and mineralized tissue-specific genes in cementoblasts J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-09 Sema S. Hakki, Serife Buket Bozkurt, Anton Sculean, Darko Božić
It has been repeatedly demonstrated that cementum formation is a crucial step in periodontal regeneration. Hyaluronic acid (HA) is an important component of the extracellular matrix which regulates cells functions and cell–cell communication. Hyaluronic acid/derivatives have been used in regenerative periodontal therapy, but the cellular effects of HA are still unknown. To investigate the effects of
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Periodontitis causally affects the brain cortical structure: A Mendelian randomization study J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-07 Mengqiao Wang, Ziyao Wang, Delu Zhao, Yajie Yu, Fulan Wei
To estimate whether genetically proxied periodontitis causally impacts the brain cortical structure using Mendelian randomization (MR).
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High glucose impairs human periodontal ligament cells migration through lowered microRNAs 221 and 222 J. Periodont. Res. (IF 3.5) Pub Date : 2023-12-01 Mariana Marin Monteiro, Cibele Crastequini Gomes, Mario Costa Cruz, Anna Carolina R. Tempestini Horliana, Dânia Emi Hamassaki, Cilene Rebouças Lima, Marinilce F. Santos
To investigate the effects of miR-221 and miR-222 and high glucose on human periodontal ligament (PL) cells morphology, cytoskeleton, adhesion, and migration.
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Periodontitis is associated with altered brain structure and function in normal cognition middle-aged and elderly individuals J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-28 Xiaoshu Li, Yufei Tao, Hui Li, Ziang Huang, Yuqing Li, Ziwen Gao, Wanqiu Zhu, Xiaohu Li, Yongqiang Yu
Numerous studies have proposed that periodontitis is a potential risk factor for Alzheimer's disease. However, the association between periodontitis and brain normal cognition in aged and elderly individuals (NCs) is unclear. Such a link could provide clues to Alzheimer's disease development and strategies for early prevention.
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Erratum: Calcitriol suppresses lipopolysaccharide-induced alveolar bone damage in rats by regulating T helper cell subset polarization J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-28 C.-S. Bi, J. Wang, H.-L. Qu, X. Li, B.-M. Tian, S.-H. Ge, F.-M. Chen
Bi CS, Wang J, Qu HL, et al. Calcitriol suppresses lipopolysaccharide-induced alveolar bone damage in rats by regulating T helper cell subset polarization. J Periodontal Res. 2019;54(6):612–623. doi:10.1111/jre.12661 In the original published version of the paper, the same flow cytometry images were reused for different samples in Figure 5A–C. After a careful re-examination of our original data in
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Ability of gingival crevicular fluid volume, E-cadherin, and total antioxidant capacity levels for predicting outcomes of nonsurgical periodontal therapy for periodontitis patients J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-27 Hind R. Hussein, Ali A. Abdulkareem, Mike R. Milward, Paul R. Cooper
To determine the potential of gingival crevicular fluid (GCF) volume, E-cadherin and total antioxidant capacity (TAC) levels to predict the outcomes of nonsurgical periodontal therapy (NSPT) for periodontitis patients.
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Elucidating the molecular healing of intrabony defects following non-surgical periodontal therapy: A pilot study J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-27 Vasiliki P. Koidou, Eleni Hagi-Pavli, Luigi Nibali, Nikolaos Donos
To elucidate the molecular healing of intrabony defects following non-surgical periodontal therapy (NSPT) using gingival crevicular fluid (GCF).
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Preclinical evaluation of a new synthetic carbonate apatite bone substitute on periodontal regeneration in intrabony defects J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-23 Jean-Claude Imber, Larissa Carmela Imber, Andrea Roccuzzo, Alexandra Stähli, Fernando Muñoz, Jens Weusmann, Dieter Daniel Bosshardt, Anton Sculean
To evaluate the potential of a novel synthetic carbonate apatite bone substitute (CO3Ap-BS) on periodontal regeneration.
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Periodontitis exacerbation during pregnancy in mice: Role of macrophage migration inhibitory factor as a key inductor J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-21 Betsaida J. Ortiz-Sánchez, Imelda Juárez-Avelar, Antonio Andrade-Meza, Mónica Gabriela Mendoza-Rodríguez, Yolanda I. Chirino, Eric Monroy-Pérez, Gloria Luz Paniagua-Contreras, Miriam Rodriguez-Sosa
The present study was designed to investigate the role of macrophage migration inhibitory factor (MIF) in the exacerbation of pregestational periodontal disease (PGPD).
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Serum asprosin levels are increased in patients with periodontitis and ST-segment elevation myocardial infarction and correlated with periodontal parameters: A case–control study J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-20 Sema Nur Sevinç Gül, Oğuzhan Birdal, Esra Laloğlu
The study aims to investigate whether patients with ST-elevation myocardial infarction (STEMI)-related periodontitis will experience any changes in asprosin levels.
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Bioinformatics analysis reveals the potential common genes and immune characteristics between atrial fibrillation and periodontitis J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-16 Jie Xiang, Jiaru Cao, Jun Shen, Xiaoyan Wang, Junqing Liang, Xinshang Li, Ling Zhang, Baopeng Tang
Atrial fibrillation (AF) and periodontitis, both classified under chronic inflammatory diseases, share common etiologies, including genetic factors and immune pathways. However, the exact mechanisms are still poorly understood. This study aimed to explore the potential common genes and immune characteristics between AF and periodontitis.
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Salivary miR-150-5p as an indicator of periodontitis severity and regulator of human periodontal ligament fibroblast behavior by targeting AIFM2 J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-15 Jing Huang, Yuejing Xu, Pengcheng Huang
This study aimed to evaluate the role of miR-150-5p in the onset and progression of periodontitis, and reveal the potential molecular mechanism underlying its function and to explore a novel biomarker for periodontitis.
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The signaling pathways involved in non-coding RNA regulation during osteogenic differentiation of periodontal tissue-derived cells in the field of periodontitis J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-14 Yinci Zhu, Xiaoyan Guan, Xiaorui Geng, Yuanhang Du, Suhan Jin, Jianguo Liu
Periodontitis is a prevalent oral disease caused by chronic inflammation of the periodontal tissues surrounding the teeth, which can lead to bone loss, tooth loosening, and even tooth loss. This inflammation has a negative impact on the osteogenic differentiation capacity of periodontal tissue-derived cells. Non-coding RNAs (ncRNAs) are a class of RNA molecules that do not encode proteins but can regulate
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LncRNA ADAMTS9-AS2 regulates periodontal ligament cell migration under mechanical compression via ADAMTS9/fibronectin J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-13 Qianyao Yu, Kunyao Guo, Yuhui Yang, Hao Liu, Yiping Huang, Weiran Li
Periodontal ligament cells (PDLCs) are key mechanosensory cells involved in extracellular matrix (ECM) remodeling during orthodontic tooth movement (OTM). Mechanical force changes the ECM components, such as collagens and matrix metalloproteinases. However, the associations between the changes in ECM molecules and cellular dynamics during OTM remain largely uncharacterized.
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Gallic acid induces osteoblast differentiation and alleviates inflammatory response through GPR35/GSK3β/β-catenin signaling pathway in human periodontal ligament cells J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-13 Thi Hoa Pham, Eun-Nam Kim, Nguyen Minh Trang, Gil-Saeng Jeong
Gallic acid (GA) possesses various beneficial functions including antioxidant, anticancer, anti-inflammatory as well as inhibiting osteoclastogeneis. However, effects on osteogenic differentiation, especially in human ligament periodontal (hPDL) cells, remain unclear. Thus, the aim of this study was to evaluate the function of GA on osteogenesis and anti-inflammation in hPDL cells and to explore the
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LncRNA JHDM1D-AS1 promotes osteogenic differentiation of periodontal ligament cells by targeting miR-532-5p to activate IGF1R signaling J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-11 Xiaohuan Zhong, Huixin Wang
The aim of this study was to explore the mechanism underlying periodontal ligament cells (PDLCs) osteogenic differentiation.
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Interleukin-37 ameliorates periodontitis development by inhibiting NLRP3 inflammasome activation and modulating M1/M2 macrophage polarization J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-10 Liyan Yang, Wei Tao, Chen Xie, Qiuye Chen, Yunshan Zhao, Li Zhang, Xu Xiao, Shilu Wang, Xu Zheng
Our study was designed to explore the role of IL-37 in M1/M2 macrophage polarization imbalance in the pathogenesis of periodontitis.
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The impact of Resolvin E1 on bone regeneration in critical-sized calvarial defects of rat model—A gene expression and micro-CT analysis J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-10 Sara Alrumaih, Nouf Alshibani, Lamees Alssum, Fahad A. Alshehri, Mohammed A. AlMayrifi, Mohammed AlMayouf, Ali Alrahlah, Leonel S. J. Bautista
To investigate, in vivo, the effect of local application of Resolvin E1 (RvE1) on the bone regeneration of critical-size defects (CSDs) in Wistar rats utilizing gene expression and micro-computed tomographic (micro-CT) analysis.
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The effects of severe periodontitis on arterial stiffness using cardio-ankle vascular index in patients with type 2 diabetes J. Periodont. Res. (IF 3.5) Pub Date : 2023-11-01 Gizem Torumtay Cin, Semin Melahat Fenkci, Ismail Doğu Kiliç, Halil Serdar Aslan, Cihan İlyas Sevgican, Hande Şenol
Arterial stiffness, which is a measure of the elasticity of the arteries, is also a risk factor for the development of cardiovascular diseases and its measurement is important for evaluating the atherosclerosis process. The purpose of this cross-sectional study to investigate whether severe periodontitis in short-term type 2 diabetes may be associated with increased cardio-ankle vascular index (CAVI)
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Resveratrol modulates the inflammatory response in hPDLSCs via the NRF2/HO-1 and NF-κB pathways and promotes osteogenic differentiation J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-31 Yifan Ma, Yi Qian, Yuteng Chen, Xiaoxu Ruan, Xiaoya Peng, Yi Sun, Jue Zhang, Jingjing Luo, Songlin Zhou, Chao Deng
The purpose of this study was to investigate resveratrol's specific role as an anti-inflammatory and osteogenic differentiation of hPDLSCs in periodontitis and to reveal the mechanisms involved.
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Caspase-3 and gasdermin E mediate macrophage pyroptosis in periodontitis J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-26 Xiangru Gao, Shuhan Li, Wenxuan Wang, Xiangyan Zhang, Xinbo Yu, Chun Fan, Wei Li, Caixiu Yang, Lei Wang, Qiuxia Ji
Periodontitis is a chronic inflammatory disease linked to pyroptosis, an inflammatory cell death process. Macrophages are essential for maintaining microenvironment homeostasis, which is crucial for periodontal health. This study explores the mechanisms underlying the relationship between macrophage pyroptosis and periodontitis.
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Runx2 heterozygosity alters homeostasis of the periodontal complex J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-26 Ni Xiong, Jung-Sub An, Heein Yoon, Hyun-Mo Ryoo, Won Hee Lim
Haploinsufficiency of Runx2 (Runx2+/−) causes dental anomalies. However, little is known about the involvement of Runx2 in the maintenance of dentin, cementum, and the periodontal ligament (PDL) during adulthood. This study aimed to observe the effects of Runx2+/− on homeostasis of the periodontal complex.
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Granzyme B promotes matrix metalloproteinase-1 (MMP-1) release from gingival fibroblasts in a PAR1- and Erk1/2-dependent manner: A novel role in periodontal inflammation J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-24 Mohamed Ben-Eltriki, Amir Reza Ahmadi, Yuya Nakao, Kalyan Golla, Flavia Lakschevitz, Lari Häkkinen, David J. Granville, Hugh Kim
To gain insights into how proteases signal to connective tissues cells in the periodontium.
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Use of ultrasound imaging for assessment of the periodontium: A systematic review J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-23 Carlos Alberto Figueredo, Raisa Queiroz Catunda, Monica P. Gibson, Paul W. Major, Fabiana T. Almeida
The objective of this study was to systematically review the literature regarding diagnostic applications of ultrasound imaging for evaluation of the periodontium in humans. The search was conducted on Medline, EMBASE, Web of Science, Scopus, Cochrane, and PubMed up to April 3, 2023. The studies included were exclusively human studies that assessed the periodontium with ultrasound (US) imaging (b-mode)
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Association between Mediterranean diet and periodontitis among US adults: The mediating roles of obesity indicators J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-16 Yuying Wu, Baochang He, Qiansi Chen, Rong Yu, Yuxuan Wu, Han Yang, Yiming Yu, Fuhua Yan, Yanfen Li, Fa Chen
This study aimed to assess the association between the Mediterranean diet (MedDiet) and periodontitis in US adults and to further explore the mediating roles of obesity indicators in this association.
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O-GlcNAcylation of TLR4 inhibits osteogenic differentiation of periodontal ligament stem cells J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-10 Bohan Yu, Qin Li, Xi Sun, Yue Yin
Toll-like receptor 4 (TLR4)-mediated inflammatory responses are associated with diabetes and periodontitis, which are dysregulated by O-GlcNAcylation.
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The osteogenic effects of sappanchalcone in vitro and in vivo J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-09 Xiaodan Zheng, Jingqiu Chen, Juan Liu, Xiaoying Shi, Gang Li, Qimeng Shi, Jun Zhang, Yanhong Li
The utilization of natural products to enhance the function of periodontal ligament cells (PDLCs) has emerged as a popular area of research. Recent investigations have demonstrated that sappanchalcone (SC) possesses pharmacological properties such as anti-inflammatory and osteoprotective effects. This study aims to explore the impact of SC on the in vivo and in vitro osteogenic differentiation ability
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Adjunctive use of omega-3 fatty acids in combination with low-dose aspirin in periodontitis: Systematic review and meta-analysis J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-03 Olga A. Neprelyuk, Sergey I. Zhad'ko, Inessa G. Romanenko, Maxim A. Kriventsov
Periodontitis is one of the most common dental diseases with a range of treatment approaches, including pathogenetically reasonable use of various host immune modulators. One such approach is the use of omega-3 polyunsaturated fatty acids (PUFAs) in combination with low-dose aspirin. This systematic review and meta-analysis were performed to compare the standard treatment alone and adjunctive use of
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Metabolomics analysis in saliva from periodontally healthy, gingivitis and periodontitis patients J. Periodont. Res. (IF 3.5) Pub Date : 2023-10-03 Meaad M. Alamri, Benjamin Williams, Adrien Le Guennec, Giuseppe Mainas, Pasquale Santamaria, David L. Moyes, Luigi Nibali
The aim of this study was to investigate metabolomics markers in the saliva of patients with periodontal health, gingivitis and periodontitis.
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Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation J. Periodont. Res. (IF 3.5) Pub Date : 2023-09-28 Yixin Xu, Yixin Wang, Hui Xiao, Yongming Li
This research aimed to elucidate the molecular mechanisms underlying the periodontitis-associated bone loss, with particular emphasis on the contributory role of hypoxic microenvironment in this process.
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Microbial biomarkers as a predictor of periodontal treatment response: A systematic review J. Periodont. Res. (IF 3.5) Pub Date : 2023-09-19 Ren Jie Jacob Chew, Charlene Enhui Goh, Gopu Sriram, Philip M. Preshaw, Kai Soo Tan
To evaluate the prognostic accuracy of microbial biomarkers and their associations with the response to active periodontal treatment (APT) and supportive periodontal therapy (SPT). Microbial dysbiosis plays a crucial role in the disease processes of periodontitis. Biomarkers based on microbial composition may offer additional prognostic value, supplementing the limitations of current clinical parameters
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CD40-CD40 ligand interaction between periodontal ligament cells and cementoblasts enhances periodontal tissue remodeling in response to mechanical stress J. Periodont. Res. (IF 3.5) Pub Date : 2023-09-18 Yu Yamamoto, Chiharu Fujihara, Teerachate Nantakeeratipat, Masahiro Matsumoto, Takahiro Noguchi, Masae Kitagawa, Satoru Yamada, Takashi Takata, Hideki Kitaura, Shinya Murakami
We analyzed the localization and expression of Cluster of differentiation 40 ligand (CD40L) in murine periodontal tissue applied with the orthodontic force to determine the CD40L-expressing cells under mechanical stress. Furthermore, we investigated whether CD40-CD40L interaction played an important role in transducing mechanical stress between periodontal ligament (PDL) cells and cementoblasts and
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Chronic periodontitis induces the proliferation of pancreatic β-cells to cause hyperinsulinemia in a rat model J. Periodont. Res. (IF 3.5) Pub Date : 2023-09-18 Leilei Ye, Yingtao Lv, Qianqi Wu, Yiyan Chen, Xueyang Zhang, Yuan Su
The purpose of this study was to determine if chronic periodontitis (CP) may induce hyperinsulinemia and may have the effect of on pancreatic β-cell proliferation in a rat model.
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Exosomal microRNA-223 from neutrophil-like cells inhibits osteogenic differentiation of PDLSCs through the cGMP-PKG signaling pathway J. Periodont. Res. (IF 3.5) Pub Date : 2023-09-16 Zheng Zhang, Pengcheng Wang, Youli Zheng, Minghui Wang, Jiashu Chou, Zuomin Wang
Neutrophils-derived exosomes have been shown to cause tissue inflammation in many diseases, but their role in periodontitis, a neutrophil-mediated disease, is unknown. Here, we investigated the effect of neutrophil-like cells derived exosomes on osteogenic dysfunction of periodontal ligament stem cells (PDLSCs) in periodontitis.