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Characterization of cells in blood evoked from periapical tissues in immature teeth with pulp necrosis and their potential for autologous cell therapy in Regenerative Endodontics Arch. Oral Biol. (IF 3.0) Pub Date : 2024-03-11 Chengxiang Zheng, Peiru Jiang, Shan Hu, Yin Tang, Lei Dou
The objectives of this study were to isolate, characterize progenitor cells from blood in the root canals of necrotic immature permanent teeth evoked from periapical tissues and evaluate the applicable potential of these isolated cells in Regenerative Endodontics. Ten necrotic immature permanent teeth from seven patients were included. Evoked bleeding from periapical tissues was induced after chemical
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Relationship between ERCC1 and XPC polymorphisms and the susceptibility to head and neck carcinoma: A systematic review, meta-analysis, and trial sequential analysis Arch. Oral Biol. (IF 3.0) Pub Date : 2024-03-09 Mohammad Moslem Imani, Sattar Akbari, Majid Shalchi, Edris Sadeghi, Masoud Sadeghi
This meta-analysis was conducted to investigate the relationship between and polymorphisms and the risk of head and neck cancer (HNC), incorporating more studies and additional analyses. An exhaustive search of various databases, including PubMed/Medline, Web of Science, Scopus, and Cochrane Library was carried out, up until November 18, 2023, to identify pertinent studies. The Review Manager 5.3 software
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Salivary factors associated with noncarious cervical lesions: A systematic review Arch. Oral Biol. (IF 3.0) Pub Date : 2024-03-07 Natália Teixeira Tavares Branco, Anna Rachel dos Santos Soares, Daniel José Braga Dutra, Raquel Conceição Ferreira, Allyson Nogueira Moreira, Lívia Guimarães Zina, Cláudia Silami de Magalhães
This study aimed to carry out a systematic review of observational studies searching the association between salivary factors (amount and quality of saliva) and noncarious cervical lesions (NCCL) in individuals with permanent dentition. Cross-sectional, case-control, and cohort studies performed in humans with permanent dentition (population) and considering noncarious cervical lesions (outcome) in
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TGFβ signaling pathway in salivary gland tumors Arch. Oral Biol. (IF 3.0) Pub Date : 2024-03-07 Ágatha Nagli de Mello Gomes, Katia Klug Oliveira, Fabio Albuquerque Marchi, Bárbara Beltrame Bettim, Janaina Naiara Germano, João Gonçalves Filho, Clóvis Antônio Lopes Pinto, Silvia Vanessa Lourenço, Cláudia Malheiros Coutinho-Camillo
Pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (ACC) are the most prevalent salivary gland tumors. Their pathogenesis has been recently associated with complex molecular cascades, including the TGFβ signaling pathway. The aim of this study was to evaluate the expression of genes associated with the TGFβ signaling pathway (, , , , , , and ) to map possible downstream
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An enigmatic pathogenetic mechanism of hypoxia inducible factor - 1/2 alpha in the progression of fibrosis of oral submucous fibrosis and its malignant transformation: a systematic review and meta-analysis Arch. Oral Biol. (IF 3.0) Pub Date : 2024-03-05 Keerthika R, Akhilesh Chandra, Trupti Jain, Neha Singh, Rahul Agrawal
Oral submucous fibrosis is a frequently reported potentially malignant disorder characterized by fibrosis and a malignant transformation rate of 7-30%. The role of hypoxia-inducible factor-1/2α in malignant transformation mechanisms of oral submucous fibrosis remains uncharted territory owing to a scarcity of studies. Thus the present systematic review and meta-analysis aimed to determine the role
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Exploring the role of flavonoids in caries-affected dentin adhesion: A comprehensive scoping review Arch. Oral Biol. (IF 3.0) Pub Date : 2024-03-03 Camilla Karoline de Carvalho Beckman, Tainá de Lima Costa, Regina Maria Puppin-Rontani, Aline Rogéria Freire de Castilho
The aim of this scoping review was to evaluate the available scientific evidence regarding the use of flavonoids in the treatment of caries-affected dentin focusing on bonding to dentin. A comprehensive literature search was performed in five databases from March 2022 and updated in April 2023: PubMed, EMBASE, Scopus, Web of Science, and Scielo. Additionally, the references of included studies were
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Role of induced nitric oxide synthases in orofacial nociception/discomfort after dental tooth bleaching with hydrogen peroxide Arch. Oral Biol. (IF 3.0) Pub Date : 2024-03-02 Marcílio Rodrigues Pinto, Kirlya Isabel da Silva Medeiros, Letícia Menezes Maia, Antonio Alexandre Coelho, Ana Paula Negreiros Nunes Alves, Caio Ferreira Freire Caetano, Karine Cestaro Mesquita, Paulo Goberlânio de Barros Silva, Fabricio Bitu Sousa
To evaluate the role of induced nitric oxide synthase (iNOS) in nociception/orofacial discomfort in rats submitted to tooth whitening with hydrogen peroxide (H₂O₂). Wistar rats were divided into three groups (n = 24/group): a sham group not submitted to whitening treatment, a saline group submitted to whitening treatment, and a test group submitted to whitening treatment and blockade of iNOS with aminoguanidine
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EXPRESSION OF β1- AND β2-ADRENERGIC RECEPTORS IN ORAL SQUAMOUS CELL CARCINOMA AND THEIR ASSOCIATION WITH PSYCHOLOGICAL AND CLINICAL FACTORS Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-29 Ana Lívia Santos-Sousa, Giseli Mitsuy Kayahara, Daniela Brito Bastos, Bruna Amélia Moreira Sarafim-Silva, Marcelo Macedo Crivelini, Vítor Bonetti Valente, José Eduardo Corrente, Jose Candido C. Xavier-Júnior, Glauco Issamu Miyahara, Daniel Galera Bernabé
Psychological stressors have been related to tumor progression through the activation of beta-adrenergic receptors (β-AR) in several types of cancer. Purpose: This study aimed to investigate the expressions of β- and β-AR and their association with psychological and clinicopathological variables in patients with oral squamous cell carcinoma. Methods: Tumor samples from 99 patients diagnosed with OSCC
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How geographical origin and dietary habits interact with the shape of cortical mandibular sections? A geometric morphometrics study in an archaeological context Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-29 Pierre-Hadrien Decaup, Elsa Garot, Nicolas Vanderesse, Christine Couture
Mandibular shape is strongly influenced by biomechanics, particularly during dietary shifts that often occurred in past populations. The relationship is considered extremely complex as development of the mandible is a multifactorial process. Since cortical bone distribution is purportedly more biomechanically sensitive than external shape, comparison of its distribution in past populations can provide
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Digital measurement of deciduous tooth dimensions in China: a cross-sectional survey Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-28 Tianyi Zhang, Xiaoli Gao, Chao Huang, Shenping Su, Xiaoping Lin, Lijun Yin, Qingwei Bi, YongJie Fan, Jiang Lin, Jianming Wei, Yingping Liu, Lin Chai, Mingyan Xu, Xiaotao Chen, Wenyi Zhong, Xianghong Yang, Qingbin Zhang, Jing Gao, Zuomin Wang, Zhiqiang Liu
Crown dimensions data of deciduous teeth hold anthropological, forensic, and archaeological value. However, such information remains scarce for the Chinese population. This multi-center study aimed to collect a large sample of deciduous crown data from Chinese children using three-dimensional measurement methods and to analyze their dimensions. A total of 1592 children's deciduous dentition samples
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In vitro antimetastatic potential of pseudolaric acid B in HSC-3 human tongue squamous carcinoma cell line Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-27 Hyun-Ju Yu, Ji-Hoon Kim, Su-Jung Choi, Sung-Dae Cho
Pseudolaric acid B (PAB) is a novel diterpenoid derived from the traditional Chinese medicinal herb that exerts anticancer, anti-inflammatory, and immunomodulatory properties. While the anticancer potential of PAB has been studied, its effects on metastasis have not been well-studied. This study aims to determine the inhibitory effects of PAB on HSC-3 human tongue squamous cell carcinoma (TSCC) cell
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Oral microbiota of adolescents with dental caries: A systematic review Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-27 Francien Veenman, Anne van Dijk, Alexandre Arredondo, Carolina Medina-Gomez, Eppo Wolvius, Fernando Rivadeneira, Gerard Àlvarez, Vanessa Blanc, Lea Kragt
This systematic review summarizes the current knowledge on the association between the oral microbiota and dental caries in adolescents. An electronic search was carried out across five databases. Studies were included if they conducted research on generally healthy adolescents, applied molecular-based microbiological analyses and assessed caries status. Data extraction was performed by two reviewers
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The Archaea domain: Exploring historical and contemporary perspectives with in silico primer coverage analysis for future research in Dentistry Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-23 Jéssica Alves de Cena, Aline Belmok, Cynthia Maria Kyaw, Naile Dame-Teixeira
The complete picture of how the human microbiome interacts with its host is still largely unknown, particularly concerning microorganisms beyond bacteria. Although existing in very low abundance and not directly linked to causing diseases, archaea have been detected in various sites of the human body, including the gastrointestinal tract, oral cavity, skin, eyes, respiratory and urinary systems. But
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Up-regulation of extracellular-matrix and inflammation related genes in oral squamous cell carcinoma Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-22 Vaidehi P. Thakore, Kinjal D. Patel, Hemangini H. Vora, Prabhudas S. Patel, Nayan K. Jain
Oral squamous cell carcinoma (OSCC) is the most prevalent malignancy with late-presentation, site-specific heterogeneity, and high-propensity for recurrence/metastasis that has shown rise in mortality. Lately, research emphasize on dynamic interactions between tumor-cells and extracellular-matrix components within tumor-microenvironment that promote tissue integrity loss and carcinogenesis. Therefore
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Triggering receptor expressed in myeloid cells 1 (TREM1) as a potential prognostic biomarker and association with immune infiltration in oral squamous cell carcinoma Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-22 Balachander Kannan, Chandra Pandi, Anitha Pandi, Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam
The objective of this study is to investigate the significance and impact of Triggering Receptor Expression on Myeloid Cells-1 (TREM-1) in the context of oral squamous cell carcinoma (OSCC). This study involved 51 OSCC patients, 21 oral epithelial dysplasia patients (OED), and the TCGA-HNSCC dataset. TREM1 expression was analyzed using quantitative reverse transcription PCR (RT-qPCR), and Western blot
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Age-related difference in oral adaptation to masticatory perturbation Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-17 Chia-Shu Lin, Yi-Chen Chen, Li-Jung Chao, Wei-Chieh Kao, Ta-Chung Chen
Mastication can be influenced by intraoral perturbation (e.g., hard food). We developed the masticatory perturbation task (MPT) to assess the perturbation effect during mastication and quantify the degree of adaptation to masticatory perturbation in younger and older adults. Thirty-eight younger and 38 older participants completed the MPT, which consisted of three trials assessing masticatory performance
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Dental health status of the medieval silver-mining community from Kutná Hora (Czech Republic, 13th–16th c.): Impact of socioeconomic changes and mortality crises Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-16 Hana Brzobohatá, Šárka Bejdová, Alena Černíková, Filip Velímský, Jan Frolík, Petr Velemínský
The aim of the study was to evaluate the pathological conditions in teeth from skeletal remains found in the medieval burial ground at Kutná Hora (13th–16th centuries, Czech Republic). We focused on the effect on dental health of socioeconomic changes associated with the boom in silver mining at the site. In this study, dental caries and antemortem tooth loss were recorded for 469 sexed adults (10
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Redox biomarkers in saliva and nuclear abnormalities in jugal epithelial cells of individuals with type 2 diabetes mellitus and periodontitis Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-16 Walder Jansen de Mello Lobão, Lenita Zajdenverg, Gustavo Casimiro Lopes, Maria Cynésia Medeiros de Barros, Carmelo Sansone, Carina M. Silva-Boghossian
To evaluate salivary redox biomarkers levels in individuals with periodontitis and type 2 diabetes mellitus (T2DM) and correlate with periodontal parameters and nuclear alterations in epithelial cells from jugal mucosa. Design: Sixty individuals were categorized into three groups: T2DM with periodontitis (DM, n = 20), non-T2DM with periodontitis (PE, n = 20), and non-T2DM with periodontal health (HC
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D-alanine suppressed osteoclastogenesis derived from bone marrow macrophages and downregulated ERK/p38 signalling pathways Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-13 Xiaochi Chang, Jing Deng, Fengyi Zhou, Zhihao Geng, Xin Li, Shuai Wang
D-alanine is a residue of the backbone structure of Type Ⅰ Lipoteichoic acid (LTA), which is a virulence factor in inflammation caused by gram-positive bacteria. However, the role of D-alanine in infectious bone destruction has not been investigated. We aimed to explore the role of D-alanine in the proliferation, apoptosis, and differentiation of osteoclasts. Mouse bone marrow-derived macrophages (BMMs)
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Carbon dots combined with phytosphingosine inhibit acid-induced demineralization of hydroxyapatite in vitro Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-05 Cuicui Fu, Henk S. Brand, Kamran Nazmi, Arie Werner, Annina van Splunter, Floris J. Bikker
To study the effects of carbon dots (CDs), in combination with phytosphingosine (PHS), against acid-induced demineralization of hydroxyapatite . CDs were generated from citric acid and urea by microwave heating. Transmission electron microscope (TEM), FT-IR, and fluorescence intensity were used to characterize the CDs. A hydroxyapatite (HAp) model was used to investigate the protective effects of CDs
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The yes-associated protein-1 (YAP1) inhibitor celastrol suppresses the ability of transforming growth factor β to activate human gingival fibroblasts Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-05 Angha Naik, Pratyusha Chitturi, John Nguyen, Andrew Leask
To determine whether celastrol, an inhibitor of the mechanosensitive transcriptional cofactor yes-associated protein-1 (YAP1), impairs the ability of TGFβ1 to stimulate fibrogenic activity in human gingival fibroblast cell line. Human gingival fibroblasts were pre-treated with celastrol or DMSO followed by stimulation with or without TGFβ1 (4ng/ml). We then utilized bulk RNA sequencing (RNAseq), real-time
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Analysis of head motions during food intake in Japanese adults using a new motion capture system Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-03 Kohei Chinju, Yushi Yamamoto, Emi Inada, Yoichiro Iwashita, Hideo Sato
A new motion capture system was developed to verify the hypothesis that “during food intake, head motion changes according to the properties of the food.” Twenty healthy males and 20 healthy females with right-handed and normal occlusion participated in this study. The motion capture system used consisted of a Microsoft Xbox One Kinect Sensor® and a newly-developed program. Meatballs (solid), yogurt
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TFEB regulates the odontoblastic differentiation of dental pulp stem cells by promoting a positive feedback loop between mitophagy and glycolysis Arch. Oral Biol. (IF 3.0) Pub Date : 2024-02-01 Yiming Li, Enli Yang, Yiming Geng, Mingyang Li, Xuan Wang, Dongsheng Zhang
To evaluate the regulatory effect of transcription factor EB (TFEB) on the odontoblastic differentiation of dental pulp stem cells(DPSCs) in vivo RNA-seq was used to detect differentially expressed genes in differentiated DPSCs. Lysosomes and the expression of the related gene TFEB were examined in DPSCs. DPSCs were then transfected with lentivirus for TFEB-overexpression. Cell proliferation was detected
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Resveratrol is an inhibitory polyphenol of epithelial-mesenchymal transition induced by Fusobacterium nucleatum Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-22 Jie Min, Chiho Mashimo, Takayuki Nambu, Hugo Maruyama, Hiroki Takigawa, Toshinori Okinaga
Objective Resveratrol is a natural phytoalexin that has anti-inflammatory properties, reverses doxorubicin resistance, and inhibits epithelial-mesenchymal transition (EMT) in many types of cancer cells. Fusobacterium nucleatum is reportedly enriched in oral squamous cell carcinoma (OSCC) tissues compared to adjacent normal tissues, sparking interest in the relationship between F. nucleatum and OSCC
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Association between alcohol dehydrogenase polymorphisms (rs1229984, rs1573496, rs1154460, and rs284787) and susceptibility to head and neck cancers: A systematic review and meta-analysis Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-22 Mohammad Moslem Imani, Mohamad Mehdi Moradi, Farzad Rezaei, Hamid Reza Mozaffari, Roohollah Sharifi, Mohsen Safaei, Fatemeh Azizi, Masoumeh Basamtabar, Zahra Sohrabi, Majid Shalchi, Masoud Sadeghi
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NOTUM plays a bidirectionally modulatory role in the odontoblastic differentiation of human stem cells from the apical papilla through the WNT/β-catenin signaling pathway Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-20 Qingxuan Zhao, Huihui Ren, Nan Wang, Xiaojing Yuan, Yuming Zhao, Quan Wen
Objective Notum is a secreted deacylase, which is crucial for tooth dentin development in mice. This study aimed to investigate the effect of NOTUM on the odontoblastic differentiation of human stem cells from the apical papilla (hSCAPs), to reveal the potential value of NOTUM in pulp-dentin complex regeneration. Design The expression pattern of NOTUM in human tooth germs and during in vitro odontoblastic
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Variation in enamel prism size in primate molars Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-17 Ian Towle, Carolina Loch
Objective This study examines whether larger enamel prism diameters accommodate a greater enamel volume from the enamel-dentine junction (EDJ) to the outer-enamel surface (OES) in primate molars, and how prism size relates to enamel thickness and crown location. Design We assessed variation in enamel prism diameter in relation to crown location and enamel thickness in catarrhine lower molars (n = 14
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Association between raftlin and presepsin levels with periodontal healthy and disease conditions Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-12 Eda Çetin Özdemir, Meral Uzunkaya, Hasan Gündoğar, Ergül Belge Kurutaş
Objective The aim of this study was to examine the association between Raftlin and Presepsin levels in periodontal healthy/diseases, hypothesizing a change in their levels. Also, the study aimed to determine their potential role in diagnosing and predicting the prognosis of periodontal diseases. Design A cross-sectional study design was used, including 20 periodontally healthy individuals, 21 gingivitis
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Patterns and sexual dimorphism of non-syndromic hypodontia among a French orthodontic population Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-12 Anaïs Cavare, Pierre-Hadrien Decaup, Marie-José Boileau, Elsa Garot
Objectives This retrospective study aimed to estimate the prevalence of non-syndromic congenitally missing teeth (CMT) and to explore the frequency of CMT patterns in a French orthodontic population. In addition, the study sought to assess sex-based differences in CMT patterns. Design Panoramic radiographs of 4569 orthodontic patients between 9 and 21 years-old performed over a 16-year period (2006–2022)
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Nociceptive and histomorphometric evaluation of the effects of ozone therapy on the rat masseter muscle in a carrageenan model of myofascial pain Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-12 Kelvin Borges Rocha de Souza, Lysianne Rodrigues de Almeida Guerra, Marcos Lázaro da Silva Guerreiro, Luciana Lyra Casais-e-Silva, Marcio Cajazeira Aguiar
Objective This study evaluated the effects of intramuscular ozone therapy on nociception, inflammation, and tissue damage caused by the injection of carrageenan in the masseter muscle of rats. Design Rat masseter muscles were injected with saline or carrageenan. Seventy-seven adult male rats were divided into six groups: Sal, saline; Car, carrageenan; Ibup + Sal, ibuprofen and saline; Ibup + Car, ibuprofen
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Autophagy induced by hypoxia in pulpitis is mediated by HIF-1α/BNIP3 Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-05 Xiaohe Wang, Zeyu Wu, Yangyang Zhang, Bingjie Lian, Li Ma, Jin Zhao
Objective Hypoxia-inducible factor-1α (HIF-1α) and its downstream factor, 19 kDa BCL-2 interacting protein 3 (BNIP3), promote cellular autophagy under hypoxic conditions. However, their roles in pulpitis are unclear. Therefore, the changes in inflammatory response and autophagy levels caused by hypoxia during pulpitis were evaluated. Additionally, the regulatory mechanism of HIF-1α/BNIP3 in cellular
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Oral bacteriome and oral potentially malignant disorders: A systematic review of the associations Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-08 Pamela Pignatelli, Maria Cristina Curia, Gianluca Tenore, Danilo Bondi, Adriano Piattelli, Umberto Romeo
Introduction Periodontal bacteria can infiltrate the epithelium, activate signaling pathways, induce inflammation, and block natural killer and cytotoxic cells, all of which contribute to the vicious circle of carcinogenesis. It is unknown whether oral dysbiosis has an impact on the etiology or prognosis of OPMD. AIMS Within this paradigm, this work systemically investigated and reported on the composition
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Evaluation of the differences in the localization of the lingula mandibulae according to pubertal development in children: A new anthropological and forensic approach Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-07 Hakan Eren, Berkant Sezer, Yeşim Deniz
Objective This study aims to investigate changes in lingula mandibulae localization before and after puberty and sex differences. Design 288 panoramic radiographs evaluated retrospectively were divided into four groups according to pubertal development: under and over 10 years old for females and under and over 11 years old for males. Four anatomic sites were used as reference points: (a) the anterior
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Influence of the radius of Monson’s sphere and excursive occlusal contacts on masticatory function of dentate subjects Arch. Oral Biol. (IF 3.0) Pub Date : 2024-01-04 Dominique Ellen Carneiro, Luiz Ricardo Marafigo Zander, Carolina Ruppel, Giancarlo De La Torre Canales, Rubén Auccaise-Estrada, Alfonso Sánchez-Ayala
Objective To determine the influence of the radius of Monson’s sphere, the number of posterior laterotrusive, mediotrusive, and protrusive contacts, and the chewing rate on food comminution. Design Sixty healthy dentate subjects, aged 21.22 ± 2.30 years, were selected. The three-dimensional coordinates of the cusp tips of the lower canine, premolar, and molar teeth were identified from the subjects’
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Molecular mechanisms underlying the effect of tooth shortening on memory dysfunction in Wistar male rat Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-30 Ali Esmaeili, Shiva Ebrahimpour, Kimiya Forouzandeh Hefshejani, Abolghasem Esmaeili
Objective We investigated the effects of molar tooth shortening on the mRNA expression of the AβPP/BACE1, BDNF/TrkB, and Bax/Bcl-2 signaling pathways in the Wistar male rat hippocampal regions. Design Four groups (n = 5 per group) of male Wistar rats (control, SRM (shortened right molar), SLM (shortened left molar), and SBM (shortened bilateral molar)) were used. RNA was isolated from the hippocampus
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Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-26 Henrique Hadad, Henrique R. Matheus, Sara I. Pai, Francisley A. Souza, Fernando P.S. Guastaldi
Objective To assess the outcomes of several rodent animal models for studying tooth extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design After a search of the databases, 2004 articles were located, and 118 corroborated the inclusion factors (in vivo studies in rodents evaluating tooth extraction as a risk factor for the development of MRONJ). Results Numerous studies attempting
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Impact of obesity on the structures and functions of the stomatognathic system: A morphofunctional approach Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-26 Isabela Hallak Regalo, Marcelo Palinkas, Ligia Maria Napolitano Gonçalves, Paulo Batista de Vasconcelos, Annalisa Cappella, Riccardo Solazzo, Claudia Lucia Pimenta Ferreira, Claudia Dolci, Simone Cecilio Hallak Regalo, Chiarella Sforza, Selma Siessere
Objective The prevalence of obesity is increasing significantly worldwide, raising great concern among health professionals. This observational study evaluated the electromyographic activity and thickness of the masseter and temporalis muscles, in addition to the maximum molar bite force, in obese and eutrophic subjects. Methods Sixty subjects were divided into three groups: I (7–12 years), II (13–20
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Biological properties of stem cells from the apical papilla exposed to lipopolysaccharides: An in vitro study Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-22 Cristina Bucchi, Ana Bucchi, Paulina Martínez-Rodríguez
Objective The aim of this study was to analyze the effect of lipopolysaccharides (LPS) on the biological properties of stem cells from the apical papilla (SCAPs), such as viability, adhesion to dentin, odontoblast-like differentiation, mineralization, and release of immunomodulatory cytokines. Design SCAPs were isolated from immature teeth of three donors (10 to 15 years old) and cultured in mineralizing
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Xylitol associated or not with fluoride: Is the action the same on de- and remineralization? Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-21 Thamyris Souza Carvalho, Tatiana Martini, Karen Pavan Lima, Tamara Teodoro Araújo, Chelsea Maria Vilas Boas Feitosa, Luciana Rinaudi Marron, Stacey Lavender, Larissa Tercilia Grizzo, Ana Carolina Magalhães, Marília Afonso Rabelo Buzalaf
Objectives This study evaluated the effect of xylitol combined or not with fluoride (F) on reduction of demineralization and increase of remineralization of shallow and deep artificial enamel lesions. Methods Bovine enamel samples were allocated to the following solutions groups: no xylitol (negative control), 5% xylitol, 10% xylitol, 20% xylitol, 500 ppm F (as NaF), 5% xylitol+F, 10% xylitol+F or
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Photobiomodulation effects on fibroblasts and keratinocytes after ionizing radiation and bacterial stimulus Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-16 Mylene Martins Monteiro, Juliana Amorim dos Santos, Victor Paiva Barbosa, Taia Maria Berto Rezende, Eliete Neves Silva Guerra
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Exploring the regulatory interactions between mutated genes and homeobox genes in the head and neck cancer progression Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-15 Kanaka Sai Ram Padam, Sanjiban Chakrabarty, Keith D. Hunter, Raghu Radhakrishnan
Objective Understanding the regulatory role of homeobox (HOX) and mutated genes in the progression of head and neck cancers is essential, although their interaction remains elusive. This study aims to decipher the critical regulation of mutation driven effects on homeobox genes to enhance our understanding of head and neck cancer progression. Methods Genomic mutation data from The Cancer Genome Atlas-Head
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Gross and microanatomic description of the dental pads of the Florida manatee, Trichechus manatus latirostris, and their importance to mastication Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-13 Meghan Barboza, Kiara Kallaway
Objective Florida manatee feeding ecology is critical to species survival, but the role of dental pads in feeding has received limited attention. This study characterized the gross and microscopic anatomy of the manatee’s dorsal and ventral dental pad in relation to these structures’ importance in mastication, which furthers our understanding of manatee feeding and health. Design Whole heads from 6
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Cemental and alveolar bone defects after chronic exposure to amoxicillin in rats (histopathologic and radiographic study) Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-06 Gihan S. Hassan, Basant H. AbouZaid, Rehab F. Ghouraba, H.F. Ibrahim
Objectives This study aimed to shed new light on the potential detrimental effects on cementum and adjacent alveolar bone after chronic exposure to amoxicillin. Methods Six pregnant adult Albino rats were equally divided into two groups. Saline solution and amoxicillin (100 mg/Kg) were given to rats of control and amoxicillin group, respectively from the 13th to the 21st day of pregnancy. The same
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Global variations in eruption chronology of primary teeth: A systematic review and meta-analysis Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-06 MS Muthu, S. Vandana, G. Akila, M. Anusha, D. Kandaswamy, MB Aswath Narayanan
Objectives This systematic review aimed to assess global variations in the eruption chronology of primary teeth in children and the role of sexes, jaws, and socio-economic status on eruption timing. Design An extensive search of electronic databases, grey literature, and hand-searching was carried out until April 2023 Results A total of 42,109 children, with an age range of 0–83 months were included
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Papillon-Lefevre syndrome in twelve Egyptian patients: Five novel CTSC variants and functional characterization of a missense variant and its effect on splicing Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-06 Mohamed Abdel-Hamid, Maha Abouzaid, Mostafa Mostafa, Nermeen Ahmed
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Comparison of different DNA preservation solutions for oral cytological samples Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-30 Júlia Silveira Nunes, Luisa Natalia Pimentel-Vera, Sabrina Barcelos Silva, Bianca de Bem Prunes, Pantelis Varvaki Rados, Fernanda Visioli
Objective The objective of this study was to compare the DNA preservation capacity of buccal mucosa exfoliated cells when stored in different solutions under varying time and temperature conditions. Design DNA preservation solutions, including Dimethyl sulphoxide disodium-EDTA-saturated NaCl (DESS), Tris-EDTA-NaCl-Tween20 buffer (TENT), Nucleic Acid Preservation Buffer (NAP), and phosphate-buffered
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The association of gene polymorphisms in catechol-O'methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) with temporomandibular joint disorders Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-29 Ömer Ekici, Evrim Suna Arıkan Söylemez
Objective Temporomandibular disorder (TMD) has a multifactorial etiology that includes environmental, psychological, and genetic factors. This study aimed to evaluate the possible relationship between polymorphisms in Catechol-O-methyltransferase (COMT) and β2-adrenergic receptor (ADRB2) genes with TMD. Design This observational case-control study included 80 patients and 70 healthy controls. The diagnosis
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Radiotherapy in the head and neck region influences the chemical and mechanical properties of intraradicular dentin Arch. Oral Biol. (IF 3.0) Pub Date : 2023-12-01 Alessandro Marcelo Pelloso, Matheus Elias Rossi, Rafael Resende de Miranda, Carlos José Soares, Veridiana Resende Novais
Objectives To investigate the chemical and mechanical properties of intraradicular dentin submitted to radiotherapy. Materials and methods Sixteen mandibular incisors were divided into two groups (n = 8): non-irradiated and irradiated. The irradiated teeth were obtained from head and neck radiotherapy patients, with a total dose ranging from 70.2 to 72 Gy divided into 1.8 Gy daily. After sample preparation
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Periplaneta americana extract promotes hard palate mucosal wound healing via the PI3K/AKT signaling pathway in male mice Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-29 Bin Zhao, Jie Xu, Yuan Wang, Yuhan Li, Yuyu Li, Xiao Zhang, Shiwen Zhang, Leixiao Yu, Quan Yuan
Objectives This study aimed to investigate the effect of Periplaneta americana extract, a traditional Chinese medicine, on hard palate mucosal wound healing and explore the underlying mechanisms. Design Hard palate mucosal wound model was established and the effects of Periplaneta americana extract on hard palate mucosal wound healing were investigated by stereomicroscopy observation and histological
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LncRNA urothelial cancer associated 1 promotes the osteogenic differentiation of human periodontal ligament stem cells by regulating the miR-96–5p/Osx axis Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-28 Xuefei Sun, Yu Pu, Shaojie Dong, Qianqian Dong
Objectives To investigate the expression of long non-coding RNA (lncRNA) urothelial cancer associated 1 (UCA1) in human periodontal ligament stem cells (hPDLSCs), its effect on osteogenic differentiation of hPDLSCs and its mechanism. Design The expression of osteogenic genes Osx, Runx2, Ocn and Opn was explored by qPCR. Protein expression in hPDLSCs was estimated by Western blot. The osteogenic differentiation
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The effect of a soft diet on molar dentin formation during the occlusal establishment period Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-28 Yuan Zhao, Wei Ge, Hong Chen, Yanduo Yang, Zuda Xu
Objective This study intends to investigate the effect of a soft food diet on molar dentin formation during the occlusal establishment period. It can provide dietary guidance for infants to strengthen their dental structure. Design 60 BALB/c mice were used to obtain mandibles during lactation (P0.5, P7.5, P15.5, P21.5) and occlusal establishment (P27.5, P33.5, P60.5). The mice were randomly divided
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Relating metric crown dimensions to underlying internal daily secretion rates in antimeric premolars Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-21 Kaita Gurian, Khadeejah Buzaribah, Mackie C. O’Hara, Khaled Khalaf, Paula J. Waterhouse, Wendy Dirks
Objectives The underlying cause for metric differences in antimeric tooth pairs is an important question for understanding dental variation. We hypothesize that localized variation in crown dimensions will be reflected in localized variation in daily enamel secretion rate. Design Casts of pairs of human premolars from a tissue bank were 3D scanned using an optical scanning system (n = 32). Histological
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Stem cells derived from human exfoliated deciduous teeth-based media in a rat root resorption model Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-24 Ayaka Odo, Ryo Kunimatsu, Takaharu Abe, Shuzo Sakata, Ayaka Nakatani, Kodai Rikitake, Yuma Koizumi, Izumi Tanabe, Naonobu Okimura, Yuki Yoshimi, Kotaro Tanimoto
Objective Root resorption may occur during orthodontic treatment. Herein, we investigated the effect of a culture supernatant of stem cells derived from human exfoliated deciduous teeth on root resorption. Design Twelve 8-week-old male Sprague–Dawley rats were used, and their maxillary first molars were pulled with excessive orthodontic force to induce root resorption. On days 1 and 7 after traction
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LRP1-deficient leptin receptor-positive cells in periodontal ligament tissue reduce alveolar bone mass by inhibiting bone formation Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-23 Shirabe Nishimura, Hitoshi Kariya, Yu Gakiya, Rie Shinohara, Yoshiki Nakamura, Toshihide Mizoguchi, Akiko Ohashi, Mitsuru Motoyoshi, Tadashi Ninomiya
Objective Leptin receptor-positive (LepR+) periodontal ligament (PDL) cells play a crucial role in osteogenesis during tooth socket healing and orthodontic tooth movement; however, the factors regulating osteoblast differentiation remain unclear. This study aimed to demonstrate the function of low-density lipoprotein receptor-related protein 1 (LRP1) in alveolar bone formation by examining conditional
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Mineralization and thickness of the condylar cortex in skeletal remains of children’s mandibles: A preliminary study Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-18 V. Vespasiano, C.S. Mulder, C. Klop, J.H. Koolstra, J.W. Nolte, N.H.J. Lobé, L.F.M. Beenen, A.G. Becking
Objective To explore the relationship between the volumetric bone mineral density (vBMD), the thickness of the condylar cortex (Tcortex) and the hemimandibular volumes (Vhemimandible) of symmetrical and asymmetrical mandibles of children. Design The data collection consisted of 92 archeological skeletal remains of children’s mandibles between 1 and 12 years old. The mandibles were digitalized with
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High glucose levels delay the senescence of stem cells from human exfoliated deciduous teeth by suppressing autophagy Arch. Oral Biol. (IF 3.0) Pub Date : 2023-11-17 Jinjin Lu, Lixin Zhang, Ningxin Zhu, Dan Wang, Fei Xie, Man Qin, Yuanyuan Wang
Objective In this study, we aimed to investigate the effects of varying glucose concentrations on the proliferation and senescence of stem cells from human exfoliated deciduous teeth (SHED) compared to human bone marrow-derived mesenchymal stem cells (hBMSC), and preliminarily clarify the difference of glucose metabolism between SHED and hBMSC. Design We cultured SHED and hBMSC in the presence of increasing