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Differential expression of TRKB tyrosine kinase in the two histological types of parotid salivary duct carcinoma with cancer aggressiveness Oral Oncol. (IF 4.8) Pub Date : 2024-03-12 Kazumasa Moriwaki, Yusuke Ayani, Hiroko Kuwabara, Tetsuya Terada, Masaaki Higashino, Ryo Kawata
Parotid salivary duct carcinoma (SDC) is a rare and aggressive parotid gland carcinoma (PGC). SDC has two origins: and ex pleomorphic adenoma (SDC ex PA); however, because of its rarity, the clinical and molecular features of the two types of SDC are not sufficiently understood. Here, we studied the differences in their clinicopathological and molecular features using clinical specimens while comparing
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Exosomal immune checkpoint protein (PD-L1): Hidden player in PD-1/PD-L1 blockade immunotherapy resistance in oral cancer Oral Oncol. (IF 4.8) Pub Date : 2024-03-11 Jeevitha Rajanathadurai, Jospin Sindya, Inamul Hasan Madar, Elumalai Perumal
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Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival Oral Oncol. (IF 4.8) Pub Date : 2024-03-10 Mark Zupancic, Ourania N. Kostopoulou, Stefan Holzhauser, Monika Lukoseviciute, Cecilia Jylhä, Linda Marklund, Anders Näsman, Lars Sivars, Tina Dalianis
Patients with human papillomavirus DNA positive (HPVDNA) and p16 overexpressing (p16) oropharyngeal squamous cell carcinoma (OPSCC), especially those with cancer in the tonsillar and base of tongue subsites as compared to other OPSCC subsites have a better outcome than those with only HPVDNA or only p16 cancer. Likewise having a high viral load has been suggested to be a positive prognostic factor
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Role of telemedicine in head neck cancer Oral Oncol. (IF 4.8) Pub Date : 2024-03-09 Shrikant B. Mali
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Atezolizumab plus bevacizumab in advanced Merkel cell carcinoma: A prospective study Oral Oncol. (IF 4.8) Pub Date : 2024-03-08 L. Guimaraes de Sousa, S. Liu, P. Bhosale, M. Altan, W. Darbonne, K. Schulze, S. Dervin, C. Yun, A. Mahvash, A. Verma, A. Futreal, S. Gite, E. Parra Cuentas, W.C. Cho, I. Wistuba, J.C. Yao, S.E. Woodman, D.M. Halperin, R. Ferrarotto
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Should sub-millimeter margins be deemed positive in oral cavity squamous cell carcinoma? Oral Oncol. (IF 4.8) Pub Date : 2024-03-08 Chung-Jan Kang, Li-Yu Lee, Shu-Hang Ng, Chien-Yu Lin, Kang-Hsing Fan, Wen-Cheng Chen, Jin-Ching Lin, Yao-Te Tsai, Shu-Ru Lee, Chih-Yen Chien, Chun-Hung Hua, Cheng Ping Wang, Tsung-Ming Chen, Shyuang-Der Terng, Chi-Ying Tsai, Hung-Ming Wang, Chia-Hsun Hsieh, Chih-Hua Yeh, Chih-Hung Lin, Chung-Kan Tsao, Nai-Ming Cheng, Tuan-Jen Fang, Shiang-Fu Huang, Li-Ang Lee, Ku-Hao Fang, Yu-Chien Wang, Wan-Ni Lin
While several studies have indicated that a margin status of < 1 mm should be classified as a positive margin in oral cavity squamous cell carcinoma (OCSCC), there is a lack of extensive cohort studies comparing the clinical outcomes between patients with positive margins and margins < 1 mm. Between 2011 and 2020, we identified 18,416 Taiwanese OCSCC patients who underwent tumor resection and neck
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The utility of ultrasonographic surveillance in management of a presumed branchial cleft cyst later confirmed HPV-associated oropharyngeal cancer Oral Oncol. (IF 4.8) Pub Date : 2024-03-08 Tatiana Ferraro, Alisha R. Pershad, Shaleen Arora, Esther Lee, Arjun Joshi
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Trends and predictors of unplanned hospitalization among oral and oropharyngeal cancer patients; an 8-year population-based study Oral Oncol. (IF 4.8) Pub Date : 2024-03-08 Masoud MiriMoghaddam, Babak Bohlouli, Hollis Lai, Shefali Viegas, Maryam Amin
The incidence of oral cancers, particularly HPV-related oropharyngeal cancer, is steadily increasing worldwide, presenting a significant healthcare challenge. This study investigates trends and predictors of unplanned hospitalizations for oral cavity cancer (OCC) and oropharyngeal cancer (OPC) patients in the province of Alberta, Canada. This retrospective, population-based, cohort study used administrative
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Advancing oral cancer diagnosis in Brazil: Integrating artificial intelligence with teledentistry for enhanced patient outcomes Oral Oncol. (IF 4.8) Pub Date : 2024-03-07 Lucas Alves da Mota Santana, Lara Góis Floresta, Êmilly Victória Maciel Alves, Lucas Morais Rodrigues Melo, Rammom Rocha Tavares Ferreira, Graziane Ribeiro Couto, José Alcides Almeida de Arruda, Carolina Vieira Valadares, Gina Delia Roque-Torres, Gilmagno Amado Santos, Rajiv Gandhi Gopalsamy, Paulo Ricardo Martins-Filho, Lysandro Pinto Borges
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Impact of PIK3CA and cell cycle pathway genetic alterations on durvalumab efficacy in patients with head and neck squamous cell carcinoma: Post hoc analysis of TRIUMPH study Oral Oncol. (IF 4.8) Pub Date : 2024-03-07 Dong Hyun Kim, Seung Taek Lim, Hye Ryun Kim, Eun Joo Kang, Hee Kyung Ahn, Yun-Gyoo Lee, Der Sheng Sun, Jung Hye Kwon, Sang-Cheol Lee, Hyun Woo Lee, Min Kyoung Kim, Bhumsuk Keam, Keon-Uk Park, Seong-Hoon Shin, Hwan Jung Yun
This study aimed to investigate whether genetic alterations in and the cell cycle pathways influence the efficacy of durvalumab, an immune checkpoint inhibitor, in patients with head and neck squamous cell carcinoma (HNSCC) who had previously failed platinum-based treatment. We obtained data from a phase II umbrella trial of patients with HNSCC who failed platinum-based treatment (TRIUMPH, NCT03292250)
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Clinical features and prognostic factors of nasopharyngeal carcinoma with brain metastases Oral Oncol. (IF 4.8) Pub Date : 2024-03-07 Kehui Chen, Mengting Shi, Silang Mo, Tingting Liu, Yuanyuan Zhao, Li Zhang, Shen Zhao
Brain metastasis in nasopharyngeal carcinoma is a rare occurrence, and the characteristics of patients in this subgroup remain poorly defined. This study aims to delineate the clinical features, treatment modalities, prognostic factors, and survival of nasopharyngeal carcinoma patients with brain metastasis. A retrospective analysis was conducted on patients diagnosed with nasopharyngeal carcinoma
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Evaluation of a novel model incorporating serological indicators into the conventional TNM staging system for nasopharyngeal carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-03-01 Cong Ding, Dong-Yu Dai, Zi-Kang Luo, Gao-Yuan Wang, Zhe Dong, Guan-Jie Qin, Xiao-Jing Du, Jun Ma
Non-anatomical factors significantly affect treatment guidance and prognostic prediction in nasopharyngeal carcinoma (NPC) patients. Here, we developed a novel survival model by combining conventional TNM staging and serological indicators. We retrospectively enrolled 10,914 eligible patients with nonmetastatic NPC over 2009–2017 and randomly divided them into training (n = 7672) and validation (n
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Identification of new head and neck squamous cell carcinoma molecular imaging targets Oral Oncol. (IF 4.8) Pub Date : 2024-02-29 Jeroen E. van Schaik, Bert van der Vegt, Lorian Slagter-Menkema, Bernard F.A.M. van der Laan, Max J.H. Witjes, Sjoukje F. Oosting, Rudolf S.N. Fehrmann, Boudewijn E.C. Plaat
Intraoperative fluorescence imaging (FI) of head and neck squamous cell carcinoma (HNSCC) is performed to identify tumour-positive surgical margins, currently using epidermal growth factor receptor (EGFR) as imaging target. EGFR, not exclusively present in HNSCC, may result in non-specific tracer accumulation in normal tissues. We aimed to identify new potential HNSCC FI targets. Publicly available
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Treatment package time < 14 weeks improves recurrence free and disease specific survival in HPV positive OPC with high-risk features Oral Oncol. (IF 4.8) Pub Date : 2024-02-28 Manasa Melachuri, Chareeni Kurukulasuriya, Purva Rumde, Terral Patel, Daniel Awad, Seungwon Kim, Robert Ferris, Shaum Sridharan, Umamaheswar Duvvuri
Guidelines recommend treatment package time < 85 days and time from surgery to radiation initiation < 6 weeks in head and neck cancer patients. However, HPV positive primaries treated with TORS and adjuvant radiotherapy traditionally demonstrate favorable outcomes. Single center retrospective chart review of patients diagnosed with HPV positive treatment naïve primary squamous cell carcinoma treated
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Mutation detection in saliva from oral cancer patients Oral Oncol. (IF 4.8) Pub Date : 2024-02-26 Ahmed A. Ahmed, Mateja Sborchia, Hannah Bye, Maria Roman-Escorza, Ariella Amar, Rhonda Henley-Smith, Edward Odell, Mark McGurk, Michael Simpson, Tony Ng, Elinor J. Sawyer, Christopher G. Mathew
The incidence of head and neck squamous cell carcinoma (HNSCC) continues to increase and although advances have been made in treatment, it still has a poor overall survival with local relapse being common. Conventional imaging methods are not efficient at detecting recurrence at an early stage when still potentially curable. The aim of this study was to test the feasibility of using saliva to detect
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Global gene expression profile of proliferative verrucous leukoplakia and its underlying biological disease mechanisms Oral Oncol. (IF 4.8) Pub Date : 2024-02-25 Camile S. Farah, Kate Shearston, Emma C. Turner, Michael Vacher, Simon A. Fox
Proliferative verrucous leukoplakia (PVL) is a rare and enigmatic oral potentially malignant disorder which almost invariably results in oral squamous cell carcinoma (OSCC). The aims of this project were to use transcriptome profiling to characterise PVL gene expression patterns for biomarker identification and gain insight into the molecular aetiopathogenesis of PVL. Forty-three oral cavity mucosal
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Tumor volume instead of recurrent T category predicts clinical outcome of patients with locally recurrent nasopharyngeal carcinoma salvaged by carbon ion radiation therapy Oral Oncol. (IF 4.8) Pub Date : 2024-02-22 Jiyi Hu, Qingting Huang, Weixu Hu, Fei Liang, Jing Gao, Jing Yang, Xianxin Qiu, Haojiong Zhang, Guangyuan Zhang, Jiade Jay Lu, Lin Kong
Although carbon ion radiation therapy (CIRT) substantially improves the overall survival (OS) of patients with LR-NPC, approximately 40% of the patients may develop local recurrence. The purpose of study is to assess the value of tumor volume (TV) as a predictive tool to guide individualized CIRT. Consecutive patients with LR-NPC treated using CIRT at Shanghai Proton and Heavy Ion Center between April
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Efficacy and safety of cadonilimab in previously treated recurrent or metastatic nasopharyngeal carcinoma(COMPASSION-06): A phase II multicenter study Oral Oncol. (IF 4.8) Pub Date : 2024-02-22 Qiu-Yan Chen, Shan-Shan Guo, Ying Luo, Song Qu, De-Hua Wu, Xiao-Zhong Chen, Don-Ping Chen, Xin-Tian Qin, Qin Lin, Feng Jin, Shao-Jun Lin, Zhi-Fang Yao, Wei Liu, Zhongmin Maxwell Wang, Bai-Yong Li, Michelle Xia, Rui-Hua Xu, Lin-Quan Tang, Hai-Qiang Mai
This study was designed to assess the efficacy and safety of cadonilimab monotherapy, a first-in-class, bi-specific PD-1/CTLA-4 antibody, in patients with previously treated recurrent or metastatic nasopharyngeal carcinoma (R/M−NPC). This multicenter, open-label, single-arm, phase II clinical trial enrolled patients with R/M−NPC who had failed first-line platinum-based chemotherapy and second-line
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Comments on the article titled “Factors associated with unknown primary status in head and neck squamous cell carcinoma”: Is the N status the overlooked elephant in the room? Oral Oncol. (IF 4.8) Pub Date : 2024-02-21 Giuseppe Fancello, Serena Jiang, Giuseppe Licci, Oreste Gallo
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Is the robot an instrument or an indication for transoral surgery? Oral Oncol. (IF 4.8) Pub Date : 2024-02-19 Armando De Virgilio, David Virós Porcuna, Claudio Sampieri, Andrea Costantino
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Margin to depth of invasion ratio as an indicator for stratifying close margins in early-stage oral squamous cell carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-02-19 Chun-Yang Hung, Tung-Lin Lee, Chun-Wei Chang, Cheng-Ping Wang, Mei-Chun Lin, Pei-Jen Lou, Tseng-Cheng Chen
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When cost-effectiveness analysis bites: Avoiding the pitfalls of extended dominance Oral Oncol. (IF 4.8) Pub Date : 2024-02-14 Carlo Lazzaro
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Proliferative verrucous leukoplakia: Report of a case and literature review Oral Oncol. (IF 4.8) Pub Date : 2024-02-12 Chun-Bo Dou, Yi-Hui Fu, Zi-Li Yu, Jun Jia
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Low-grade myofibroblastic sarcoma mimicking a benign neoplasm in the neck soft tissue Oral Oncol. (IF 4.8) Pub Date : 2024-02-12 Yingying Li, Pengfei Dong, Jingyao Sun, Xinlong Sun, Yuliang Wang
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Response to “lymph node ratio independently associated with postoperative thyroglobulin levels in papillary thyroid” Oral Oncol. (IF 4.8) Pub Date : 2024-02-12 Arisha Akhtar, Rinad Akhtar, Erum Zaidi
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Integrating ChatGPT in oral cytopathology: Comment Oral Oncol. (IF 4.8) Pub Date : 2024-02-12 Hinpetch Daungsupawong, Viroj Wiwanitkit
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Hyoid osteoradionecrosis as an acute sequelae of irradiation for base of tongue tumors: A complication on the rise? Oral Oncol. (IF 4.8) Pub Date : 2024-02-10 Joshua D. Smith, Shaum S. Sridharan, Kevin J. Contrera, Simon A. Brown, Molly E. Heft-Neal, Matthew E. Spector
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Major and durable responses to photon and electron-beam palliative radiotherapies after immune-checkpoint inhibitors in head and neck cancer Oral Oncol. (IF 4.8) Pub Date : 2024-02-09 Santiago Cabezas-Camarero, Gonzalo Vázquez Masedo, Fernando Puebla-Díaz, Juan Antonio Corona, Pedro Pérez-Segura
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A case report on a nasal and oral cavity involving large solitary fibrous tumor and comprehensive review of case literature Oral Oncol. (IF 4.8) Pub Date : 2024-02-09 Xing Lu, Jin-Ling Zhang, Xiang Zhai, Qing Liu, Wei Hang
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Oral cancer and oral potentially malignant disorders in patients with Fanconi anemia – A systematic review Oral Oncol. (IF 4.8) Pub Date : 2024-02-03 Nayara Conceição Marcos Santana, Ana Carolina Velasco Pondé de Sena, Paula Alves da Silva Rocha, José Alcides Almeida de Arruda, Cassius Carvalho Torres-Pereira, Lucas Guimarães Abreu, Benjamin P.J. Fournier, Saman Warnakulasuriya, Tarcília Aparecida Silva
The purpose of the present study was to perform a systematic review focusing on oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMD) in Fanconi anemia (FA) individuals. Electronic searches were undertaken in five databases supplemented by manual scrutiny and gray literature. Case reports and/or cases series were included. The searches yielded 55 studies describing 112
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Integrating ChatGPT in oral cytopathology: Enhancing fine needle aspiration diagnostic accuracy for malignant lesions Oral Oncol. (IF 4.8) Pub Date : 2024-02-02 Lucas Alves da Mota Santana, Rani Iani Costa Gonçalo, Lara Góis Floresta, Eduardo Morato de Oliveira, Leda Maria Delmondes Freitas Trindade, Lysandro Pinto Borges, Daniel Araki Ribeiro, Paulo Ricardo Martins-Filho, Wilton Mitsunari Takeshita
Abstract not available
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EGFR-targeted fluorescence imaging for precision margin assessment in oral cancer surgery Oral Oncol. (IF 4.8) Pub Date : 2024-02-02 Sesuraj Balasamy, Ashok K. Sundramoorthy
Abstract not available
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Reply to: Comment on “Transoral robotic surgery in oropharyngeal squamous cell carcinoma: A comparative study between da Vinci Single-Port and da Vinci Xi systems” Oral Oncol. (IF 4.8) Pub Date : 2024-02-01 Andrea Costantino, Claudio Sampieri, Piero Giuseppe Meliante, Armando De Virgilio, Se-Heon Kim
Abstract not available
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AI-chatbots and oral oncology: A transformative frontier in patient support Oral Oncol. (IF 4.8) Pub Date : 2024-01-30 Amol S. Dhane, Sachin Sarode
Abstract not available
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Complete tumor resection reverses neutrophilia-associated suppression of systemic anti-tumor immunity Oral Oncol. (IF 4.8) Pub Date : 2024-01-26 Amir Kaskas, Paul Clavijo, Jay Friedman, Marco Craveiro, Clint T. Allen
Tumor infiltrating neutrophils suppress T cell function, but whether neutrophils in circulation contribute to systemic immunosuppression is unclear. We aimed to study whether peripheral neutrophils that accumulate with tumor progression contribute to systemic immunosuppression, and if observed suppression of systemic anti-tumor immunity could be reversed with complete surgical tumor removal. Syngeneic
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Primary intestinal-type adenocarcinoma: Report of a rare case involving a young patient Oral Oncol. (IF 4.8) Pub Date : 2024-01-25 Thayanara Silva Melo, Carla Isabelly Rodrigues-Fernandes, Thayná Melo de Lima Morais, Oslei Paes de Almeida, Alan Roger Santos-Silva, Luiz Alcino Monteiro Gueiros
The aim of this report was to describe a rare example of sporadic intestinal-type adenocarcinoma of the major salivary glands and oral cavity. A 23-year-old female patient presented an asymptomatic, progressive-growing mass involving the floor of mouth and the left submandibular gland. Fine-needle aspiration cytology, imaging exams, and surgical specimen findings were consisted with the diagnosis of
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Perineural invasion is a poor prognostic factor for sinonasal squamous cell carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-01-25 Cheng-Wai Chou, Ming-Ying Lan, Ying-Ju Kuo, Chien-Fu Yeh
In this study, our primary objective is to elucidate the correlation between sinonasal squamous cell carcinoma (SCC) and perineural invasion (PNI), a topic that has received limited attention in prior literature. Furthermore, we have undertaken an examination of various other clinicopathological factors. We retrospectively reviewed the medical records of patients aged ≥ 20 years with newly diagnosed
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Unsung oral toxicities of antibody drug conjugate Oral Oncol. (IF 4.8) Pub Date : 2024-01-25 Prazwala Chirravur
Abstract not available
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Revolutionizing oral oncology: The role of artificial intelligence Oral Oncol. (IF 4.8) Pub Date : 2024-01-24 Vikas V. Pawar, Safia Farooqui
Abstract not available
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A spindle-cell variant of ameloblastic carcinoma arising from a pre-existing ameloblastoma Oral Oncol. (IF 4.8) Pub Date : 2024-01-24 Belini Freire-Maia, Guilherme de Souza Silva, Ricardo Alves de Mesquita, Roberta Rayra Martins-Chaves, Ricardo Santiago Gomez
Abstract not available
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Air pollution is associated with increased incidence-rate of head and neck cancers: A nationally representative ecological study Oral Oncol. (IF 4.8) Pub Date : 2024-01-23 Henrique Ochoa Scussiatto, Kerstin M. Stenson, Samer Al-Khudari, Michael J. Jelinek, Jayant M. Pinto, Mihir K. Bhayani
Early studies show conflicting findings regarding particulate matter ≤ 2.5 μm in diameter (PM) exposure and development of head and neck cancers (HNC). We analyzed the relationship between PM exposure and various types of HNC in a nationally representative ecological sample. We determined HNC incidence in 608 US counties from 2011 to 2019 using the Surveillance, Epidemiology and End Results (SEER)
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A rare case of thyroid carcinosarcoma arising from recurrent papillary thyroid cancer: Case report and review of the literature Oral Oncol. (IF 4.8) Pub Date : 2024-01-22 Yuzhang Gao, Yaoyun Tang, Xin Zhang, Ping Wu
Thyroid carcinosarcoma represents a rare subtype of thyroid cancer, distinguished by its unique histopathology-simultaneous malignant epithelial and mesenchymal cells. The occurrence of thyroid carcinosarcoma arising from recurrent papillary thyroid cancer is exceptionally infrequent. Study outlines a patient's thyroid carcinosarcoma journey, covering presentation, recurrence, diagnostics, surgeries
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Characterising B cell expression and prognostic significance in human papillomavirus positive oropharyngeal cancer Oral Oncol. (IF 4.8) Pub Date : 2024-01-22 Richard J. Young, Christopher Angel, Mathias Bressel, Angela Pizzolla, Alesha A. Thai, Sandro V. Porceddu, Howard Liu, Rejhan Idrizi, Jana Metta, Annette M. Lim, Benjamin J. Solomon, Danny Rischin
The incidence of human papillomavirus positive oropharyngeal cancer (HPV+OPC) is increasing, and new biomarkers are required to better define prognostic groups and guide treatment. Infiltrating T cells have been well studied in head and neck cancer, however the presence and role of B cells and tertiary lymphoid structures (TLS) in the tumor microenvironment has not, even though the interplay between
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A prospective, single-arm trial of PD-1 inhibitors plus chemoradiotherapy for solitary metachronous metastasis nasopharyngeal carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-01-22 Lu Li, Lu Chen, Ming Fan, Yue Tian, Hangyu Ai, Lu Yan, Fang Li, Mei Lan, Xin Lai, Yecai Huang, Peng Xu, Mei Feng, Jinyi Lang
Initial treatment for Recurrent/Metastatic Nasopharyngeal Carcinoma (R/M NPC) often involves Gemcitabine plus cisplatin with or without PD-1 inhibitors. However, PD-1 inhibitors' effectiveness varies, prompting for better treatments. This study explores effect and safety of combining PD-1 inhibitors with chemoradiotherapy for oligometastatic NPC patients. Oligometastatic NPC patients underwent radical
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Free flap monitoring of tissue oxygen saturation: A new device in oral reconstruction Oral Oncol. (IF 4.8) Pub Date : 2024-01-20 Nicola Zingaretti, Jacopo Di Filippo, Massimo Robiony, Alessandro Tel, Francesco De Francesco, Michele Riccio, Pier Camillo Parodi
Abstract not available
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Uncovering immune checkpoint heterogeneity in oral squamous cell carcinoma using single cell RNA-sequencing data highlights three subgroups of patients with distinct immune phenotypes Oral Oncol. (IF 4.8) Pub Date : 2024-01-12 Yannick Le Meitour, Jean-Philippe Foy, Mathilde Guinand, Lucas Michon, Andy Karabajakian, Jérôme Fayette, Pierre Saintigny, Karène Mahtouk
Objectives In head and neck squamous cell carcinoma (HNSCC), PD-1/PD-L1 inhibitors remain inefficient in most patients, which points to the need for better characterization of immune checkpoint (ICP) molecule expression. Material and methods We evaluated the expression of 22 ICP ligands (ICPL) in 2,176 malignant cells from 10 patients in a public single-cell RNA-sequencing dataset and in two cohorts
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External validation of the GETTEC algorithm for elective neck dissection in patients candidates for salvage total laryngectomy Oral Oncol. (IF 4.8) Pub Date : 2024-01-12 Albert Pujol, Xavier León, Anna Holgado, Cristina Valero, Katarzyna Kolanczak, Miquel Quer, David Virós
Objective To perform an external validation of the algorithm for elective treatment of the lymph node areas proposed by GETTEC for patients candidates to salvage total laryngectomy after radiotherapy. This algorithm is based on the initial lymph node status, local extension of the recurrence and time to recurrence. Material and methods Retrospective study performed in 151 patients treated with salvage
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Evolutionary dynamics of tipifarnib in HRAS mutated head and neck squamous cell carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-01-13 Sankar Jagadeeshan, Kushal Suryamohan, Nara Shin, Sooraj Mathukkada, Alexandra Boyko, Daria Melikhova, Anastasia Tsareva, Leysan Yunusova, Ekaterina Pravdivtseva, Danil Stupichev, Kirill Shaposhnikov, Angela Peterson, Lev Bednyagin, Eduardo Shugaev-Mendosa, Linda Kessler, Francis Burrows, Alan L. Ho, Nishant Agrawal, Alexander T. Pearson, Evgeny Izumchenko, Ari J. Rosenberg
Head and neck squamous cell carcinoma (HNSCC) is a highly prevalent malignancy worldwide, with a significant proportion of patients developing recurrent and/or metastatic (R/M) disease. Despite recent advances in therapy, the prognosis for patients with advanced HNSCC remains poor. Here, we present the case of a patient with recurrent metastatic HNSCC harboring an HRAS G12S mutation who achieved a
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Molecular subtyping of head and neck cancer – Clinical applicability and correlations with morphological characteristics Oral Oncol. (IF 4.8) Pub Date : 2024-01-13 Fabian Stögbauer, Raik Otto, Korinna Jöhrens, Ingeborg Tinhofer, Ulrich Keilholz, Christopher Poremba, Ulrich Keller, Ulf Leser, Wilko Weichert, Melanie Boxberg, Konrad Klinghammer
Aim We aimed to evaluate the applicability of a customized NanoString panel for molecular subtyping of recurrent or metastatic head and neck squamous cell carcinoma (R/M−HNSCC). Additionally, histological analyses were conducted, correlated with the molecular subtypes and tested for their prognostic value. Material and Methods We conducted molecular subtyping of R/M−HNSCC according to the molecular
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Extranodal follicular dendritic cell sarcoma of the tonsil: An extremely rare clinical entity Oral Oncol. (IF 4.8) Pub Date : 2024-01-14 Andrea Battisti, Marco Della Monaca, Danilo Di Giorgio, Paolo Priore, Valentina Terenzi, Valentino Valentini
Follicular dentritic cell sarcomatous neoplasms originate from dendritic cells contained within the lymph nodes. In extranodal location, these neoplasms, are rare clinical entities, and even more so, their location in the head-neck region is extremely rare. Only 17 cases of primary dendritic cell sarcoma of the tonsil are reported in the literature at present. Being such a rare entity, histopathological
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Association Between Social Determinants of Health, Distance from Treatment Center, and Treatment Type with Outcomes in Human Papillomavirus Associated Oropharyngeal cancer Oral Oncol. (IF 4.8) Pub Date : 2024-01-11 Aisha A. Aden, Felicia O. Olawuni, Chadi N. Abdel-Halim, Agnes Q. Zhu, Travis J. Haller, Thomas J. O'Byrne, Eric J. Moore, Daniel L. Price, Kendall L. Tasche, Daniel J. Ma, Scott C. Lester, Mauricio Gamez, Michelle A. Neben-Wittich, Katharine Price, Harry E. Fuentes-Bayne, David Routman, Kathryn M. Van Abel
Social determinants of health (SDOH) can influence access to cancer care, clinical trials, and oncologic outcomes. We investigated the association between SDOH, distance from treatment center, and treatment type with outcomes in human papillomavirus associated oropharyngeal squamous cell carcinoma [HPV(+)OPSCC] patients treated at a tertiary care center. Retrospective review. HPV(+)OPSCC patients treated
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Impact of tumor subsite on survival outcomes in oral squamous cell carcinoma: A retrospective cohort study from 2000 to 2019 Oral Oncol. (IF 4.8) Pub Date : 2024-01-10 Marius Meldgaard Justesen, Helene Stampe, Kathrine Kronberg Jakobsen, Amanda Oester Andersen, Jakob Myllerup Jensen, Kristoffer Juul Nielsen, Anita Birgitte Gothelf, Irene Wessel, Anders Christensen, Christian Grønhøj, Christian von Buchwald
Oral squamous cell carcinoma (OSCC) is responsible for high morbidity and mortality worldwide. Although the oral cavity encompasses different anatomical subsites, it is unclear whether subsite localization of carcinoma influences outcome. This retrospective cohort study examined overall survival (OS), recurrence-free survival (RFS) and local recurrence-free survival (L-RFS) at different subsites by
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Genetic characteristics of a highly metastatic basal cell adenocarcinoma arising in buccal mucosa Oral Oncol. (IF 4.8) Pub Date : 2024-01-05 DoYeon Kim, KyungUn Choi, HaeRyoun Park, JaeMin Song
Abstract not available
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Ethical consideration for implementing AI in healthcare: A chat GPT perspective Oral Oncol. (IF 4.8) Pub Date : 2024-01-06 Vikas V. Pawar, Safia Farooqui
Abstract not available
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Response to “Integrating pretreatment MRI-detected nodal features and Epstein-Barr virus DNA to identify optimal candidates for intensity-modulated radiotherapy alone in patients with stage II nasopharyngeal carcinoma” Oral Oncol. (IF 4.8) Pub Date : 2023-12-27 Arisha Akhtar, Rinad Akhtar, Beena Muntaha Nasir
Abstract not available
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Comment on “A systematic review and meta-analysis of osteoradionecrosis following proton therapy in patients with head and neck cancer” Oral Oncol. (IF 4.8) Pub Date : 2023-12-29 Erkan Topkan, Efsun Somay, Ugur Selek
Abstract not available
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The development of a decision aid for patients with operable oropharyngeal carcinoma in the Netherlands – A mixed methods study Oral Oncol. (IF 4.8) Pub Date : 2023-12-23 Anne N. Heirman, Richard Dirven, Lisette van der Molen, Willem H. Schreuder, Frank Hoebers, Jimmie Honings, Abrahim Al-Mamgani, Remco de Bree, Simone E.J. Eerenstein, Gyorgy B. Halmos, Michiel W.M. van den Brekel
Objective The aim of this project is to create an interactive online patient decision aid (PDA) for oropharyngeal cancer (OPSCC) patients, eligible for transoral (robotic) surgery with an ultimate goal to assist both physicians and patients in making treatment choices. Materials and methods Following the International Patient Decision Aid Standards, a mixed-methods approach was employed. The study
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Detection of serum biomarkers of HPV-16 driven oropharynx and oral cavity cancer in Brazil Oral Oncol. (IF 4.8) Pub Date : 2023-12-26 Laura Sichero, Milena Giulia Gonçalves, Fabiana Bettoni, Elisangela Monteiro Coser, Giana Mota, Rafaella A.L. Nunes, Ana Maria da Cunha Mercante, Renato Natalino, Miyuki Uno, Maria José Ferreira Alves, Leandro Luongo Matos, Luiz Paulo Kowalski, Marco Aurélio Vamondes Kulcsar, Gustavo Fernandes de Alvarenga, Daniela Höfler, Lea Schroeder, Tim Waterboer, Massimo Tommasino, Luisa Lina Villa
Background HPV-16 driven oropharynx/oral cavity squamous cell carcinomas prevalence varies globally. We evaluated the presence of HPV-16 ctDNA and HPV-16 E6 antibodies in samples obtained from participants treated at the Instituto do Cancer do Estado de Sao Paulo, ICESP, and from whom tumoral HPV DNA, HPV-16 E6*I mRNA, and p16INK4a status was also accessed. Methods HPV was genotyped by PCR-hybridization
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No BRAF p.V600E mutation detection in ameloblastoma liquid biopsy-based analysis by ddPCR Oral Oncol. (IF 4.8) Pub Date : 2023-12-25 Isadora Pereira Gomes, Lucyene Miguita, Bianca Gomes-Fernandes, Bruna Pizziolo Coura, Wagner Henriques de Castro, Juliana Garcia Carneiro, Luiz Armando De Marco, Ricardo Santiago Gomez, Luciana Bastos-Rodrigues, Carolina Cavalieri Gomes
Abstract not available